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https://www.readbyqxmd.com/read/29896412/exploration-of-novel-anti-oxidant-protein-sestrin-in-frailty-syndrome-in-elderly
#1
Nitish Rai, G Venugopalan, Rashmita Pradhan, Akash Ambastha, Ashish Datt Upadhyay, Sadanand Dwivedi, Aparajit B Dey, Sharmistha Dey
Frailty in elderly is very much familiar with a decline in the musculoskeletal system. Muscle degeneration in the lower organism was observed due to loss of anti-oxidant protein Sestrin. The aim of the study is to determine the level of Sestrin1 and Sestrin2 in the serum of frail and non-frail elderly to associate their impact in frailty syndrome. Subjects with age ≥ 65 years were enrolled from Geriatric Medicine OPD of All India Institute of Medical Sciences, New Delhi (N= 92). Among them, 51 subjects were identified as frail and rest 41 were regarded as non-frail according to "deficit accumulation model of Rockwood...
April 2018: Aging and Disease
https://www.readbyqxmd.com/read/29887887/falls-in-older-patients-with-cancer-undergoing-surgery-prevalence-and-association-with-geriatric-syndromes-and-levels-of-disability-assessed-in-preoperative-evaluation
#2
Somayeh Fahimnia, Hadi Mirhedayati Roudsari, John Doucette, Armin Shahrokni
Falls are common among older adults. However, not much is known about the prevalence of falls among older patients with cancer. In 2015, older patients with cancer referred to Geriatrics service for preoperative evaluation were assessed for fall history, basic and instrumental activities of daily living (ADL and IADL), KPS, and use of assistive device. Of 806 patients, 215 (26.7%) patients reported fall. Incidence of last fall inside and outside home was 54.4% and 45.5%, respectively. Among patients with no falls, 33...
2018: Current Gerontology and Geriatrics Research
https://www.readbyqxmd.com/read/29862247/the-relationship-of-5-aminolevulinic-acid-on-mood-and-coping-ability-in-prediabetic-middle-aged-and-older-adults
#3
Rachael K Aquino, Michael Perez, Payel Sil, Terry Shintani, Rosanne Harrigan, Beatriz Rodriguez
In 2010, approximately 79 million Americans had prediabetes and about 50 percent of those individuals were 65 years and older. The most effective diabetes prevention method in prediabetic adults is lifestyle modification. However, despite the benefits of lifestyle change, diabetes prevalence continues to increase. Maintaining a regular exercise routine and a healthy eating plan may be difficult because of the negative emotional barriers (i.e., stress, mood) that a prediabetic individual faces. This is particularly evident in older individuals when you combine that with decreases in mobility and geriatric syndromes...
June 2018: Geriatrics
https://www.readbyqxmd.com/read/29861628/management-of-ao-type-12c-humerus-proximal-metadiaphyseal-fractures-with-minimally-invasive-plate-osteosynthesis-in-geriatric-patients
#4
Firat Seyfettinoğlu, Hasan Ulaş Oğur, Ümit Tuhanioğlu, Hakan Çiçek, Ahmet Kapukaya
Background: To evaluate the treatment efficacy and complications of the lateral minimally invasive plate osteosynthesis (MIPO) method in geriatric patients with a humerus diaphyseal fracture with proximal extension. Patients and methods: The study included a total of 21 patients (18 females, 3 males; mean age 74±6.3 years, range 65-89 years) who underwent surgery with the lateral MIPO technique for a humerus diaphyseal fracture with proximal extension during the period January 2011 to December 2016...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29806864/effect-of-a-minimal-massive-intervention-in-hospitalized-older-patients-with-oropharyngeal-dysphagia-a-proof-of-concept-study
#5
A Martín, O Ortega, M Roca, M Arús, P Clavé
BACKGROUND: Oropharyngeal dysphagia (OD) is a newly defined geriatric syndrome that causes nutritional and respiratory complications in older hospitalized patients. Following hospital discharge, OD also causes hospital readmission and mortality in this population. OBJECTIVE: Our aim was to assess the effect of a minimal-massive intervention (MMI) in reducing nutritional and respiratory complications in older hospitalized patients with OD. DESIGN AND PARTICIPANTS: An open label trial was performed on 186 hospitalized older patients (>70y) with OD; 62 of these patients with OD were treated with the MMI and paired by sex, age, functionality, comorbidities and body mass index with two controls...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29803531/vertigo-and-dizziness-understanding-and-managing-fall-risk
#6
REVIEW
Jennifer C Alyono
Vertigo and dizziness are common conditions among older adults. They are closely associated with fall risk and portend major implications for geriatric injury and disability. Management can be particularly challenging, because symptoms are often nonspecific and may reflect multiple etiologies. Chronic dizziness can reflect dysfunction in the vestibular, somatosensory, or visual systems or in their central integration. Systemic processes, such as postural hypotension, arrhythmias, heart failure, medication use, and lower extremity weakness or frailty, also contribute...
May 24, 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29799055/approach-to-frailty-in-the-elderly-in-primary-care-and-the-community
#7
Christine Yuanxin Chen, Peiying Gan, Choon How How
Frailty is a distinct clinical syndrome wherein the individual has low reserves and is highly vulnerable to internal and external stressors. Although it is associated with disability and multiple comorbidities, it can also be present in individuals who seem healthy. Frailty is multidimensional and its pathophysiology is complex. Early identification and intervention can potentially decrease or reverse frailty, especially in the early stages. Primary care physicians, community nurses and community social networks have important roles in the identification of pre-frail and frail elderly through the use of simple frailty screening tools and rapid geriatric assessments...
May 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29792992/frailty-status-as-a-predictor-of-three-month-cognitive-and-functional-recovery-following-spinal-surgery-a-prospective-pilot-study
#8
Robert J Rothrock, Jeremy M Steinberger, Henry Badgery, Andrew C Hecht, Samuel K Cho, John M Caridi, Stacie Deiner
Background Context As increasing numbers of elderly Americans undergo spinal surgery, it is important to identify which patients are at highest risk for poor cognitive and functional recovery. Frailty is a geriatric syndrome which has been closely linked to poor outcomes, and short form screening may be a helpful tool for preoperative identification of at risk patients. Purpose To conduct a pilot study on the usefulness of a short-form screening tool to identify elderly patients at increased risk for prolonged cognitive and functional recovery following elective spine surgery...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29784254/evidence-based-practice-in-perianesthesia-nursing-application-of-the-american-geriatrics-society-clinical-practice-guideline-for-postoperative-delirium-in-older-adults
#9
Catherine Hebert
Delirium is a pervasive and dangerous syndrome for older adults in the perianesthesia setting, occurring in up to 60% of surgical cases. The American Geriatrics Society performed a systematic review to develop recommendations for the prevention and management of postoperative delirium in older adults. The recommendations emphasize nonpharmacologic interventions with a strong focus on reducing the use of psychoactive medication. Perianesthesia nurses can serve as leaders in translating these recommendations into evidence-based practice at the bedside for older adults...
June 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/29774174/outpatient-interventions-that-may-enhance-the-care-of-a-patient-with-co-existing-moyamoya-and-down-syndromes
#10
Anita Lwanga, Waldo Herrera, Katya Cruz Madrid, Antony Irungu
Moyamoya vasculopathy is a condition of chronic, progressive occlusion of the distal internal carotid arteries and the Circle of Willis. The resultant ischemia produces compensatory angiogenesis and the growth of a network of collateral blood vessels, which on angiography resemble a "puff of smoke" or "moyamoya" in Japanese. The objective of this case report is to describe the clinical course of a patient with Down and moyamoya syndromes and to enlighten clinicians about strategies that can be taken to enhance the care of similar patients...
March 16, 2018: Curēus
https://www.readbyqxmd.com/read/29768372/technologies-for-participatory-medicine-and-health-promotion-in-the-elderly-population
#11
Laura Nieto-Riveiro, Betania Groba, M Carmen Miranda, Patricia Concheiro, Alejandro Pazos, Thais Pousada, Javier Pereira
INTRODUCTION: The progressive aging of the population is a socio-demographic phenomenon experienced by most countries in the world in recent decades, especially in Japan and in many European Union countries. During this process, so-called "geriatric syndromes" frequently occur. The focus of this study is the quality of life of the elderly in relation to these 3 factors: risk of falls, urinary incontinence, and insomnia. OBJECTIVE: The main purpose is to determine the impact of a multifactorial intervention program implemented with institutionalized elderly people...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29745482/-%C3%A2-it-s-normal-to-get-old-and-weak-%C3%A2-should-functional-decline-be-addressed-with-elderly-patients-in-family-medicine
#12
Ophélie Viret, Joëlle Schwarz, Nicolas Senn, Yolanda Mueller
Among the health strategies to respond to the aging of the population, initiatives for the screening and management of age-related health issues are implemented, including in family medicine. Preliminary results of a qualitative study suggest that elderly people are ambivalent about anticipating age-related issues, tend to trivialize them and to be reluctant to discuss them spontaneously with their doctors. However, they find relevant that their family doctor brings up the topic with specific questions, because that allows initiating a discussion about some of these sensitive issue...
May 9, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29741193/identifying-exosome-derived-micrornas-as-candidate-biomarkers-of-frailty
#13
B R Ipson, M B Fletcher, S E Espinoza, A L Fisher
Frailty is a geriatric syndrome associated with progressive physical decline and significantly increases risk for falls, disability, hospitalizations, and death. However, much remains unknown regarding the biological mechanisms that contribute to aging and frailty, and to date, there are no clinically used prognostic or diagnostic molecular biomarkers. The present study profiled exosome-derived microRNAs isolated from the plasma of young, robust older, and frail older individuals and identified eight miRNAs that are uniquely enriched in frailty: miR-10a-3p, miR-92a-3p, miR-185-3p, miR-194-5p, miR-326, miR-532-5p, miR-576-5p, and miR-760...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29739428/incidence-and-outcomes-of-acute-kidney-injury-in-octogenarians-in-jordan
#14
Ashraf O Oweis, Sameeha A Alshelleh
OBJECTIVE: Improvements in the health care system, resulted in a greater number of geriatric patients diagnosed with acute kidney injury (AKI). We evaluated the incidence and outcome of AKI in octogenarians, as studies in the Middle-East region are few; moreover, treatment approaches, in addition to medical decisions, may require special consideration for advanced age to improve the outcomes. RESULTS: At King Abdullah II teaching and referral hospital, we recruited patients aged 80-90 years who were admitted to the medical floor between January 2010 and December 2013...
May 8, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29734698/disparate-habitual-physical-activity-and-dietary-intake-profiles-of-elderly-men-with-low-and-elevated-systemic-inflammation
#15
Dimitrios Draganidis, Athanasios Z Jamurtas, Theodoros Stampoulis, Vasiliki C Laschou, Chariklia K Deli, Kalliopi Georgakouli, Konstantinos Papanikolaou, Athanasios Chatzinikolaou, Maria Michalopoulou, Constantinos Papadopoulos, Panagiotis Tsimeas, Niki Chondrogianni, Yiannis Koutedakis, Leonidas G Karagounis, Ioannis G Fatouros
The development of chronic, low-grade systemic inflammation in the elderly (inflammaging) has been associated with increased incidence of chronic diseases, geriatric syndromes, and functional impairments. The aim of this study was to examine differences in habitual physical activity (PA), dietary intake patterns, and musculoskeletal performance among community-dwelling elderly men with low and elevated systemic inflammation. Nonsarcopenic older men free of chronic diseases were grouped as ‘low’ (LSI: n = 17; 68...
May 4, 2018: Nutrients
https://www.readbyqxmd.com/read/29730710/frailty-in-hematologic-malignancy
#16
REVIEW
Thuy T Koll, Ashley E Rosko
PURPOSE OF REVIEW: Older adults with hematologic malignancy are a growing demographic. Estimating risk of chemotherapy toxicity based on age alone is an unreliable estimate of quality of life, functional capacity, or risk of treatment complications. RECENT FINDINGS: Dedicated geriatric assessment tools can aid the clinician in identifying geriatric syndromes such as frailty, resulting in improved prognostication to decrease morbidity and mortality. Frailty is not synonymous with individual performance status and is dynamic...
May 5, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29720298/addressing-the-shortage-of-geriatric-specialists
#17
Casandra A Holveck, Jeannette Y Wick
With a population that is increasingly "gray," our nation faces a shortage of primary care providers who specialize in geriatrics. The number of geriatricians per 10,000 adults older than 65 years of age has decreased steadily since 2000. Health care providers from all disciplines (medicine, nursing, and pharmacy) tend not to choose geriatrics as a specialty area. Some are intimidated by the complexity of caring for elderly patients with geriatric syndromes and multiple morbidities. Others, who have little exposure to geriatrics in their undergraduate and graduate programs, are simply unaware of the personal and professional rewards associated with practice in geriatrics...
March 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29717762/adherence-to-the-mediterranean-diet-and-the-risk-of-frailty-in-old-people-a-systematic-review-and-meta-analysis
#18
Y Wang, Q Hao, L Su, Y Liu, S Liu, B Dong
BACKGROUND: Frailty is a common geriatric syndrome in old people. It remains controversial whether Mediterranean diet could prevent old people from developing into frailty. The aim of this study is to summarize the relevant studies and assess the effectiveness of adherence to Mediterranean diet on frailty in old people. METHOD: A systematic search of MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials was conducted to identify all relevant studies up to Oct 2017...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29701640/wearable-sensors-and-the-assessment-of-frailty-among-vulnerable-older-adults-an-observational-cohort-study
#19
Javad Razjouyan, Aanand D Naik, Molly J Horstman, Mark E Kunik, Mona Amirmazaheri, He Zhou, Amir Sharafkhaneh, Bijan Najafi
Background: The geriatric syndrome of frailty is one of the greatest challenges facing the U.S. aging population. Frailty in older adults is associated with higher adverse outcomes, such as mortality and hospitalization. Identifying precise early indicators of pre-frailty and measures of specific frailty components are of key importance to enable targeted interventions and remediation. We hypothesize that sensor-derived parameters, measured by a pendant accelerometer device in the home setting, are sensitive to identifying pre-frailty...
April 26, 2018: Sensors
https://www.readbyqxmd.com/read/29699938/black-white-disparity-in-physical-performance-among-older-women-with-newly-diagnosed-non-metastatic-breast-cancer-exploring-the-role-of-inflammation-and-physical-activity
#20
Cynthia Owusu, Mark Schluchter, Siran M Koroukian, Kathryn H Schmitz, Nathan A Berger
OBJECTIVE: To examine racial differences in physical performance among older women with newly diagnosed non-metastatic breast cancer and identify clinical, behavioral and biological factors that might contribute to such disparities. METHODS: This is a cross-sectional study of women aged ≥65 years with newly diagnosed stage I-III breast cancer recruited from ambulatory oncology clinics at an academic center, between September 2010 and August 2015. Participants completed a Comprehensive Geriatric Assessment and laboratory testing for biomarkers of inflammation [interleukin-6 (IL6)] prior to receiving systemic treatment for cancer...
April 23, 2018: Journal of Geriatric Oncology
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