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https://www.readbyqxmd.com/read/28107703/how-universal-is-coverage-and-access-to-diagnosis-and-treatment-for-chagas-disease-in-colombia-a-health-systems-analysis
#1
Zulma M Cucunubá, Jennifer M Manne-Goehler, Diana Díaz, Pierre Nouvellet, Oscar Bernal, Andrea Marchiol, María-Gloria Basáñez, Lesong Conteh
Limited access to Chagas disease diagnosis and treatment is a major obstacle to reaching the 2020 World Health Organization milestones of delivering care to all infected and ill patients. Colombia has been identified as a health system in transition, reporting one of the highest levels of health insurance coverage in Latin America. We explore if and how this high level of coverage extends to those with Chagas disease, a traditionally marginalised population. Using a mixed methods approach, we calculate coverage for screening, diagnosis and treatment of Chagas...
January 4, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28107625/gold-nanoshell-mediated-remote-myotube-activation
#2
Attilio Marino, Satoshi Arai, Yanyan Hou, Andrea Degl'Innocenti, Valentina Cappello, Barbara Mazzolai, Young-Tae Chang, Virgilio Mattoli, Madoka Suzuki, Gianni Ciofani
Mild heat stimulation of muscle cells within the physiological range represents an intriguing approach for the modulation of their functions. In this work, photothermal conversion was exploited to remotely stimulate striated muscle cells by using gold nanoshells (NS) in combination with near-infrared (NIR) radiation. Temperature increments of approximately 5°C were recorded by using an intracellular fluorescent molecular thermometer and were demonstrated to efficiently induce myotube contraction. The mechanism at the base of this phenomenon was thoroughly investigated and was observed to be a Ca2+-independent event directly involving actin-myosin interactions...
January 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28107614/sirt1-dependent-anti-senescence-effects-of-cell-deposited-matrix-on-human-umbilical-cord-mesenchymal-stem-cells
#3
Long Zhou, Xi Chen, Tao Liu, Caihong Zhu, Michelle Si, Joseph Jargstorf, Mao Li, Guoqing Pan, Yihong Gong, Zong-Ping Luo, Huilin Yang, Ming Pei, Fan He
Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) are considered an attractive cell source for tissue regeneration. However, environmental oxidative stress can trigger premature senescence in MSCs and thus compromises their regenerative potential. Extracellular matrix (ECM) derived from MSCs has been shown to facilitate cell proliferation and multilineage differentiation. This investigation evaluated the effect of cell-deposited decellularized ECM (DECM) on oxidative stress-induced premature senescence in UC-MSCs...
January 20, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28107573/diversity-and-bioprospecting-of-actinomycete-endophytes-from-the-medicinal-plants
#4
REVIEW
Nalini Monnanda Somaiah, Harishchandra Sripathy Prakash
The endophytic actinomycetes constitute one of the fascinating group of microorganisms associated with a wide range of plant species. The diversity of actinomycetes in plants and their tissue parts is a matter of debate as no consensus are derived between individual studies. Nevertheless, their diversity correlates with the occurrence in plant species harbored in unique regions of biologically diverse areas called 'hot spots'. Recent advances in the isolation techniques have facilitated the isolation of rare taxa from these environments...
January 20, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28107567/news-announcements-american-society-for-laser-medicine-and-surgery-inc
#5
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28107533/improvement-of-therapeutic-efficacy-of-oral-immunotherapy-in-combination-with-regulatory-t-cell-inducer-kakkonto-in-a-murine-food-allergy-model
#6
Yuka Nagata, Takeshi Yamamoto, Michie Hayashi, Shusaku Hayashi, Makoto Kadowaki
Oral immunotherapy (OIT) has been considered a promising approach for food allergies (FAs). However, the current OIT strategy is limited in terms of the long-term efficacy and safety. We have previously demonstrated that kakkonto, a traditional Japanese herbal medicine, suppresses the occurrence of allergic symptoms in a murine model of ovalbumin (OVA)-induced FA, which is attributed to the induction of the Foxp3+ CD4+ regulatory T cells. In this study, we established an OIT model using the FA mice with already established allergic symptoms and determined whether kakkonto could improve the efficacy of OIT...
2017: PloS One
https://www.readbyqxmd.com/read/28107475/review-and-analysis-of-publication-trends-over-three-decades-in-three-high-impact-medicine-journals
#7
Alexander Ivanov, Beata A Kaczkowska, Saadat A Khan, Jean Ho, Morteza Tavakol, Ashok Prasad, Geetha Bhumireddy, Allan F Beall, Igor Klem, Parag Mehta, William M Briggs, Terrence J Sacchi, John F Heitner
CONTEXT: Over the past three decades, industry sponsored research expanded in the United States. Financial incentives can lead to potential conflicts of interest (COI) resulting in underreporting of negative study results. OBJECTIVE: We hypothesized that over the three decades, there would be an increase in: a) reporting of conflict of interest and source of funding; b) percentage of randomized control trials c) number of patients per study and d) industry funding...
2017: PloS One
https://www.readbyqxmd.com/read/28107396/mixfit-methodology-for-computing-ancestry-related-genetic-scores-at-the-individual-level-and-its-application-to-the-estonian-and-finnish-population-studies
#8
Toomas Haller, Liis Leitsalu, Krista Fischer, Marja-Liisa Nuotio, Tõnu Esko, Dorothea Irene Boomsma, Kirsten Ohm Kyvik, Tim D Spector, Markus Perola, Andres Metspalu
Ancestry information at the individual level can be a valuable resource for personalized medicine, medical, demographical and history research, as well as for tracing back personal history. We report a new method for quantitatively determining personal genetic ancestry based on genome-wide data. Numerical ancestry component scores are assigned to individuals based on comparisons with reference populations. These comparisons are conducted with an existing analytical pipeline making use of genotype phasing, similarity matrix computation and our addition-multidimensional best fitting by MixFit...
2017: PloS One
https://www.readbyqxmd.com/read/28107319/how-could-i-balance-continuing-to-work-while-pursuing-a-degree-%C3%A2
#9
Laurie B Kofstad
In October 2010, the Institute of Medicine released the report The Future of Nursing: Leading Change, Advancing Health, which called for 80% of all nurses to have a BSN degree by 2020. This expectation was overwhelming and, in the beginning, I felt like it was an insult. I have had my associate degree in nursing for more than 20 years. All I could ask was: How can I have worked so many years and now be considered a subpar nurse? Regardless, the fact remained that I needed to return to college and obtain a higher degree...
February 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28107212/atypical-recurrence-of-takotsubo-syndrome-giant-t-wave-inversion-and-huge-qtc-prolongation
#10
Amedeo Pergolini, Giordano Zampi, Daniele Pontillo, Enzo Venturini, Paolo Giuseppe Pino, Francesco Musumeci
In this image in clinical medicine, we describe a recurrence case of Takotsubo syndrome with multifaceted ECG presentation.
January 19, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28107153/human-trafficking-mental-illness-and-addiction-avoiding-diagnostic-overshadowing
#11
Hanni Stoklosa, Marti MacGibbon, Joseph Stoklosa
This article reviews an emergency department-based clinical vignette of a trafficked patient with co-occurring pregnancy-related, mental health, and substance use disorder issues. The authors, including a survivor of human trafficking, draw on their backgrounds in addiction care, human trafficking, emergency medicine, and psychiatry to review the literature on relevant general health and mental health consequences of trafficking and propose an approach to the clinical complexities this case presents. In their discussion, the authors explicate the deleterious role of implicit bias and diagnostic overshadowing in trafficked patients with co-occurring addiction and mental illness...
January 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28107102/effects-of-traditional-chinese-medicine-dilong-injection-on-random-skin-flap-survival-in-rats
#12
Lina Xu, Dingsheng Lin, Bin Cao, Dongnan Ping
BACKGROUND: Dilong injection as a medicinal preparation extracted from earthworm in traditional Chinese medicine, is used to activate blood circulation and remove blood stasis. In this research, we aim to investigate its potential effect on random skin flap survival in rat models. MATERIALS AND METHODS: McFarlane flaps were established in 60 male Sprague-Dawley rats randomly divided into two groups: the control group and the Dilong injection group. Diong injection group was injected with the Diong injection (4 mL/kg) once a day for seven days, and the control group was given an equal volume of saline solution...
January 20, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28107065/cumulative-author-indexjournal-of-avian-medicine-and-surgery-volume-30-2016
#13
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28107062/editorial-acknowledgments
#14
(no author information available yet)
We would like to acknowledge and extend our sincere gratitude to the following people for contributions of their time, expertise, and guidance as reviewers of manuscripts for the Journal of Avian Medicine and Surgery from December 2, 2015 through November 22, 2016.
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28107013/quaternary-n-2-pyridyl-dabco-salts-one-pot-in-situ-formation-from-pyridine-n-oxides-and-reactions-with-nucleophiles-a-mild-and-selective-route-to-substituted-n-2-pyridyl-n-ethylpiperazines
#15
Dmitry I Bugaenko, Marina A Yurovskaya, Alexander V Karchava
The N-(2-pyridyl)-N'-ethylpiperazines are important structural motifs in several medicinally relevant compounds. Known synthetic methods toward these structures are multistep and generally based on the SNAr-chemistry; their applicability is significantly limited to substrates containing electron-withdrawing groups. Here we describe a new methodology for a rapid and modular access to this privileged scaffold. Importantly, the developed protocol proved to be very general and efficient for the substrates containing substituents of different electronic nature...
January 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28106992/discovery-of-n-pyridin-4-yl-1-5-naphthyridin-2-amines-as-potential-tau-pathology-pet-tracers-for-alzheimer-s-disease
#16
Frederik J R Rombouts, José-Ignacio Andrés, Manuela Ariza, José Manuel Alonso, Nigel Austin, Astrid Bottelbergs, Lu Chen, Vladimir Chupakhin, Erna Cleiren, Katleen Fierens, Alberto Fontana, Xavier Langlois, Joseph E Leenaerts, Jonas Mariën, Carolina Martinez Lamenca, Rhys Salter, Mark E Schmidt, Paula Te Riele, Cindy Wintmolders, Andrés A Trabanco, Wei Zhang, Gregor J Macdonald, Diederik Moechars
A mini-HTS on 4000 compounds selected using 2D fragment-based similarity and 3D pharmacophoric and shape similarity to known selective tau aggregate binders identified N-(6-methylpyridin-2-yl)quinolin-2-amine 10 as a novel potent binder to human AD aggregated tau with modest selectivity versus aggregated β-amyloid (Aβ). Initial medicinal chemistry efforts identified key elements for potency and selectivity, as well as suitable positions for radiofluorination, leading to a first generation of fluoroalkyl-substituted quinoline tau binding ligands with sub-optimal physicochemical properties...
January 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28106847/combination-of-morroniside-and-diosgenin-prevents-high-glucose-induced-cardiomyocytes-apoptosis
#17
Wen-Xia Pi, Xiao-Peng Feng, Li-Hong Ye, Bao-Chang Cai
Cornus officinalis and Dioscorea opposita are two traditional Chinese medicines widely used in China for treating diabetes mellitus and its complications, such as diabetic cardiomyopathy. Morroniside (Mor) of Cornus officinalis and diosgenin (Dio) of Dioscorea opposita formed an innovative formula named M + D. The aims of the present study were to investigate myocardial protective effect of M + D on diabetic cardiomyopathy (DCM) through the inhibition of expression levels of caspase-3 protein, and identify the advantage of M + D compared with Mor, Dio, and the positive drug metformin (Met)...
January 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28106829/advances-in-monitoring-cell-based-therapies-with-magnetic-resonance-imaging-future-perspectives
#18
REVIEW
Ethel J Ngen, Dmitri Artemov
Cell-based therapies are currently being developed for applications in both regenerative medicine and in oncology. Preclinical, translational, and clinical research on cell-based therapies will benefit tremendously from novel imaging approaches that enable the effective monitoring of the delivery, survival, migration, biodistribution, and integration of transplanted cells. Magnetic resonance imaging (MRI) offers several advantages over other imaging modalities for elucidating the fate of transplanted cells both preclinically and clinically...
January 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28106687/superficial-parotidectomy-plane-for-debulking-surgery-in-kimura-disease
#19
Rohit Sharma
Kimura disease (KD) is a rare chronic inflammatory disorder of unknown etiology representing as solitary or multiple subcutaneous nodules predominantly in the head and neck region. Common sites of involvement are preauricular region, forehead and scalp. The soft tissue localization is often associated with regional lymphadenopathy and enlargement of the major salivary gland. The authors report a patient with KD involving the right parotid and left temporal region managed successfully at our center using a combination of debulking superficial parotidectomy and medicinal therapy...
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28106677/the-academic-progression-in-nursing-initiative-the-final-year-outcomes
#20
Tina Gerardi
In 2012, the American Organization of Nurse Executives (AONE), representing the Tri-Council of Nursing, namely, AONE, the American Association of Colleges of Nursing, the American Nurses Association, and the National League for Nursing, was selected by the Robert Wood Johnson Foundation as the national program office for the Academic Progression in Nursing (APIN) initiative. This article discusses the impact APIN has had in the 9 states that received APIN grants, essential elements for successful APIN projects, and highlights of the last year of the grant in moving closer to the 80/20 goal from the Institute of Medicine...
February 2017: Journal of Nursing Administration
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