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https://www.readbyqxmd.com/read/28334053/new-insights-of-altered-lipid-profile-in-fragile-x-syndrome
#1
Artuela Çaku, Nabil G Seidah, Audrey Lortie, Nancy Gagné, Patrice Perron, Jean Dubé, Francois Corbin
BACKGROUND: Fragile X Syndrome (FXS) is the main genetic cause of autism and intellectual deficiency resulting the absence of the Fragile X Mental Retardation Protein (FMRP). Clinical picture is characterized by cognitive impairment associated with a broad spectrum of psychiatric comorbidities including autism spectrum disorders and attention-deficit/hyperactivity disorders. Some of these disorders have been associated with lipid abnormalities and lower cholesterol levels. Since lipids are important for neuronal development, we aim to investigate the lipid profile of French Canadian-FXS individuals and to identify the altered components of cholesterol metabolism as well as their association with clinical profile...
2017: PloS One
https://www.readbyqxmd.com/read/28333243/polycystic-ovary-syndrome-is-associated-with-anogenital-distance-a-marker-of-prenatal-androgen-exposure
#2
Yingchen Wu, Guangzheng Zhong, Shengfu Chen, Chengyu Zheng, Dehua Liao, Meiqing Xie
STUDY QUESTION: Is the presence of polycystic ovary syndrome (PCOS) associated with anogenital distance (AGD), a biomarker for the prenatal hormonal environment? SUMMARY ANSWER: The presence of PCOS is associated with longer AGD. WHAT IS KNOWN ALREADY: Although the aetiology of PCOS is unclear, emerging data suggest that the natural history of PCOS may originate from intrauterine life. Prenatal exposure to androgen hormones is considered an important factor of PCOS...
March 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28328714/somatic-profile-of-the-elite-boulderers-in-poland
#3
Mariusz Ozimek, Marcin Krawczyk, Emilian Zadarko, Zbigniew Barabasz, Tadeusz Ambroży, Arkadiusz Stanula, Dawid K Mucha, Adam Jurczak, Dariusz Mucha
Ozimek, M, Krawczyk, M, Zadarko, E, Barabasz, Z, Ambroży, T, Stanula, A, Mucha, DK, Jurczak, A, and Mucha, D. Somatic profile of the elite boulderers in Poland. J Strength Cond Res 31(4): 963-970, 2017-The study was designed to determine the values of selected somatic characteristics, body proportions, and the somatotype of elite bouldering climbers in Poland and to establish the relationships between the values of the somatic characteristics and climber's performance in bouldering. The study was conducted in a group of elite sport climbers (n = 10) who were ranked by the Polish Mountaineering Association in 2011, 2012, and 2013...
April 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28326290/effects-of-probiotic-supplementation-on-lipid-profile-of-women-with-rheumatoid-arthritis-a-randomized-placebo-controlled-clinical-trial
#4
Elnaz Vaghef-Mehrabany, Leila Vaghef-Mehrabany, Mohammad Asghari-Jafarabadi, Aziz Homayouni-Rad, Karim Issazadeh, Beitullah Alipour
Background: Probiotics are live beneficial microorganisms which may exert hypolipidemic effects through many mechanisms. Lipid profile disturbances are frequently reported in rheumatoid arthritis (RA) patients. The objective of this study was to evaluate the effects of Lactobacillus casei on serum lipids of RA women. Methods: In the present parallel randomized double-blind placebo-controlled clinical trial, 60 RA patients were recruited and divided into 2 groups. They received either a daily capsule containing 10(8) CFU of L...
2017: Health Promotion Perspectives
https://www.readbyqxmd.com/read/28321313/correlation-study-of-adenosine-deaminase-and-its-isoenzymes-in-type-2-diabetes-mellitus
#5
Lokendra Bahadur Sapkota, Sangita Thapa, Nuwadatta Subedi
OBJECTIVE: Adenosine deaminase (ADA) plays an important role in cell-mediated immunity and modulation of insulin activity. Its clinical and diagnostic significance in Nepalese type 2 diabetes is not yet characterized. So, this study's objective was to determine the isoenzymatic activities of ADA (ADA1, ADA2, and total ADA) and show its correlation with demographic, anthropometric, and biochemical characteristics of type 2 Nepalese subjects with diabetes. RESEARCH DESIGN AND METHODS: This is a hospital-based cross-sectional study including 80 type 2 diabetes mellitus (DM) patients and same number of age-matched and sex-matched healthy controls...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28321254/does-good-aerobic-capacity-attenuate-the-effects-of-aging-on-cardiovascular-risk-factors-results-from-a-cross-sectional-study-in-a-latino-population
#6
Giovanna Valentino, Mónica Acevedo, Lorena Orellana, María José Bustamante, Verónica Kramer, Marcela Adasme, Fernando Baraona, Gastón Chamorro, Jorge Jalil, Carlos Navarrete
Background. High aerobic capacity is associated with low cardiovascular (CV) risk. The aim of this study was to determine the CV RF burden in subjects with aerobic capacity ≥10 METs and compare it with those having <10 METs. Methods. Cross-sectional study in 2646 subjects (mean age 48 ± 12 years). Demographics, medical history, physical activity, cardiovascular RFs, fasting lipids and blood glucose levels, blood pressure, and anthropometric measurements were collected. Aerobic capacity was determined by exercise stress test...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28315850/associations-between-obesity-adverse-behavioral-patterns-and-cardiovascular-risk-factors-among-adolescent-inhabitants-of-a-greek-island
#7
Anastasia Garoufi, Evangelos E Grammatikos, Anastasios Kollias, Emmanuel Grammatikos, George S Stergiou, Alexandra Soldatou
BACKGROUND: Excess weight, unhealthy lifestyle habits and their sequelae have become a well-recognized public health problem in most countries. The objective of the study was to examine the relationship of adolescent overweight/obesity with behavioral habits and their association with blood pressure (BP) and lipid profile. METHODS: Anthropometric parameters, lifestyle, BP and lipid profile of 736 adolescents were evaluated cross-sectionally. The classifications of normal weight, overweight and obese were based on BMI z-scores...
March 20, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28303367/effects-of-long-term-multicomponent-exercise-on-health-related-quality-of-life-in-older-adults-with-type-2-diabetes-evidence-from-a-cohort-study
#8
Liliana C Baptista, Gonçalo Dias, Nelba R Souza, Manuel T Veríssimo, Raul A Martins
PURPOSE: To establish the effect of a long-term multicomponent exercise (LTMEX) intervention (24 months) on health-related quality of life (HRQoL), in older adults with type 2 diabetes (T2D). METHODS: This longitudinal retrospective cohort study analyzes the effects of a supervised LTMEX program on HRQoL in older adults with T2D (n = 279). Participants underwent one of two conditions: LTMEX (n = 241) trained three times per week; and unchanged lifestyle-the control group (CO; n = 38)...
March 16, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28302123/relationship-between-non-high-density-lipoprotein-cholesterol-and-carotid-atherosclerosis-in-normotensive-and-euglycemic-chinese-middle-aged-and-elderly-adults
#9
Hui Ma, Huandong Lin, Yu Hu, Xiaoming Li, Wanyuan He, Xuejuan Jin, Jian Gao, Naiqing Zhao, Boshen Pan, Xin Gao
BACKGROUND: We investigate whether non-high-density lipoprotein cholesterol (non-HDL-C) provides a better estimate of cardiovascular risk than other lipid profiles in normotensive and euglycemic middle-aged and elderly adults. METHODS: A total of 512 males and 958 females were enrolled from the Changfeng Study. A standard interview, anthropometric measurements and laboratory analyses were performed for each participant. Bilateral carotid intima-media thicknesses (CIMTs) were measured using ultrasonography, and the presence of carotid plaques was assessed...
March 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28295504/testosterone-therapy-has-positive-effects-on-anthropometric-measures-metabolic-syndrome-components-obesity-lipid-profile-diabetes-mellitus-control-blood-indices-liver-enzymes-and-prostate-health-indicators-in-elderly-hypogonadal-men
#10
O Canguven, R A Talib, W El Ansari, D-J Yassin, M Salman, A Al-Ansari
To alleviate late-onset hypogonadism, testosterone treatment is offered to suitable patients. Although testosterone treatment is commonly given to late-onset hypogonadism patients, there remains uncertainty about the metabolic effects during follow-ups. We assessed the associations between testosterone treatment and wide range of characteristics that included hormonal, anthropometric, biochemical features. Patients received intramuscular 1,000 mg testosterone undecanoate for 1 year. Patient anthropometric measurements were undertaken at baseline and at each visit, and blood samples were drawn at each visit, prior to the next testosterone undecanoate...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28293638/metabolic-disorders-in-hiv-infected-adolescents-receiving-protease-inhibitors
#11
Jeerunda Santiprabhob, Surapong Tanchaweng, Sirinoot Maturapat, Alan Maleesatharn, Watcharee Lermankul, Sirintip Sricharoenchai, Orasri Wittawatmongkol, Keswadee Lapphra, Wanatpreeya Phongsamart, Kulkanya Chokephaibulkit
Protease inhibitor (PI) may cause abnormal glucose metabolism, abnormal lipid metabolism, and metabolic syndrome in HIV-infected adults but less well studied in Asian adolescents. This cross-sectional study evaluated anthropometric factors, oral glucose tolerance test, and lipid profiles of perinatally HIV-infected Thai adolescents who had received PI-based antiretroviral therapy for at least 6 months. Eighty adolescents were enrolled [median (IQR) age 16.7 (14.6-18.0) years, 42 males]. Metabolic syndrome, prediabetes, and type 2 diabetes mellitus (T2DM) were found in 8 (10%), 17 (22...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28292365/serum-neopterin-a-potential-marker-for-screening-blood-donors
#12
Ahsan Ashfaq, Ayesha Ejaz, Ghazanfar Abbas
OBJECTIVE: To determine serum neopterin levels in blood donors of local population and its association with transfusion transmitted infections. STUDY DESIGN: A cross-sectional observational study. PLACE AND DURATION OF STUDY: Department of Physiology, Liaquat National Hospital and Medical College (LNHMC) in collaboration with Basic Medical Sciences Institute (BMSI) and Jinnah Postgraduate Medical Centre (JPMC), Blood Bank, Karachi, Pakistan, from January to June 2015...
January 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28285653/the-use-of-magnetic-resonance-imaging-to-characterize-abnormal-body-composition-phenotypes-in-youth-with-prader-willi-syndrome
#13
Camila E Orsso, Michelle Mackenzie, Angela S Alberga, Arya M Sharma, Lawrence Richer, Daniela A Rubin, Carla M Prado, Andrea M Haqq
INTRODUCTION: Magnetic resonance imaging (MRI) provides detailed assessment of body composition compartments. No studies have employed state-of-the-art MRI methods to accurately examine abdominal adipose tissue (AT) and skeletal muscle in youth with Prader-Willi syndrome (PWS). Therefore, this study aimed to describe AT distribution and skeletal muscle in the abdominal region of youth with PWS using MRI. METHODS: Anthropometric measures and whole-abdominal T1-weighted MRI were performed in sixteen (5 males and 11 females) youth diagnosed with PWS, and seventeen (10 males and 7 females) youth who did not have PWS (controls)...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28283395/proprotein-convertase-subtilisin-kexin-type-9-pcsk9-and-metabolic-syndrome-components-among-young-adult-females
#14
Hayder Hasan, Amita Attlee, Veena Raigangar, Mohamed Madkour, Samir Awadallah
AIMS: Occurrence of metabolic syndrome (MetS) in the United Arab Emirates (UAE) is rising steadily, with subsequent increase in the prevalence of type 2 diabetes and cardiovascular disease (CVD). Recent studies have shown that PCSK9 plays a substantial role in atherogenic dyslipidemia. Hence, the aim of this study was to assess level of PCSK9 and its relationship with MetS components among young adult females. METHODS: This study was carried out on 137 adult females over 18 years of age residing in the UAE...
March 6, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28280715/enterotype-may-drive-the-dietary-associated-cardiometabolic-risk-factors
#15
Ana C F de Moraes, Gabriel R Fernandes, Isis T da Silva, Bianca Almeida-Pititto, Everton P Gomes, Alexandre da Costa Pereira, Sandra R G Ferreira
Analyses of typical bacterial clusters in humans named enterotypes may facilitate understanding the host differences in the cardiometabolic profile. It stills unknown whether the three previously described enterotypes were present in populations living below the equator. We examined how the identification of enterotypes could be useful to explain the dietary associations with cardiometabolic risk factors in Brazilian subjects. In this cross-sectional study, a convenience sample of 268 adults (54.2% women) reported their dietary habits and had clinical and biological samples collected...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28270027/hair-cortisol-concentrations-exhibit-a-positive-association-with-salivary-cortisol-profiles-and-are-increased-in-obese-prepubertal-girls
#16
Chrysanthe Papafotiou, Eirini Christaki, Erica L T van den Akker, Vincent L Wester, Filia Apostolakou, Ioannis Papassotiriou, George P Chrousos, Panagiota Pervanidou
Cortisol, a key mediator of the stress response, has been associated with obesity and metabolic syndrome manifestations as early as in childhood. Scalp hair cortisol has been proposed as a reliable index of long-term circulating cortisol. We aimed to investigate whether obese prepubertal girls have higher scalp hair cortisol than normal-weight controls, and whether hair cortisol levels are correlated with salivary cortisol concentrations in these groups. In this cross-sectional study, 25 obese girls and 25 normal-weighted, age-matched girls were enrolled...
March 7, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28264459/a-cross-sectional-study-of-the-prevalence-of-metabolic-syndrome-and-associated-factors-in-colombian-collegiate-students-the-fuprecol-adults-study
#17
Javier Martínez-Torres, Jorge Enrique Correa-Bautista, Katherine González-Ruíz, Andrés Vivas, Héctor Reynaldo Triana-Reina, Daniel Humberto Prieto-Benavidez, Hugo Alejandro Carrillo, Jeison Alexander Ramos-Sepúlveda, Emilio Villa-González, Antonio García-Hermoso, Robinson Ramírez-Vélez
Metabolic syndrome (MetS) is one of the major public health problems worldwide. The objective of the present study is to investigate the prevalence and the associated variables of MetS in Colombian collegiate students. This cross-sectional study included a total of 890 (52% women) healthy collegiate students (21.3 ± 3.2 years old). The prevalence of MetS was determined by the definition provided by the International Diabetes Federation (IDF). We further examined associations between the prevalence of MetS and related factors, such as age, gender, anthropometric and body composition, weight status, and nutrition profile...
February 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28262196/serum-chemerin-in-obese-children-and-adolescents-before-and-after-l-carnitine-therapy-relation-to-nonalcoholic-fatty-liver-disease-and-other-features-of-metabolic-syndrome
#18
Rasha T Hamza, Zeinab A Elkabbany, Ahmed M Shedid, Amira I Hamed, Asmaa O Ebrahim
BACKGROUND AND AIMS: Chemerin plays an important role in metabolic syndrome (MetS) including nonalcoholic fatty liver disease (NAFLD). L-carnitine (LC) may reduce plasma glucose, lipid profile, and improve liver function. The aim of the study was to assess serum chemerin in obese children with suspected NAFLD, the effect of LC on NAFLD grade, chemerin and metabolic profile. METHODS: Fifty obese children were compared to 50 controls. All were subjected to anthropometric assessment, liver function, fasting lipid profile, glucose/insulin (G/I) ratio, homeostasis model assessment (HOMA) index, serum chemerin and abdominal ultrasonography before and after LC...
October 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/28260758/association-of-metabolic-syndrome-with-hyper-apolipoprotein-b-status-in-young-people-with-acute-coronary-syndrome
#19
G P Aditya, M S Bari, M A Bari, M A Mutalib, G K Paul
Prevalence of Metabolic Syndrome (MetS) and acute coronary syndrome (ACS) in young people is progressively increasing. This was originally a case control study to predict the risk of ACS with hyper apolipoprotein B (Hyper apoB) status in young people, with 50 cases of 18-45 years of age of both sex with first attack of acute coronary syndrome admitted in Coronary care unit of Mymensingh Medical College Hospital from June 2009 to May 2010 and for comparison, equal number of age and sex matched healthy controls were chosen...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28260396/disorders-of-serum-omega-3-fatty-acid-composition-in-dialyzed-patients-and-their-associations-with-fat-mass
#20
Małgorzata Sikorska-Wiśniewska, Adriana Mika, Tomasz Śledziński, Sylwia Małgorzewicz, Piotr Stepnowski, Bolesław Rutkowski, Michał Chmielewski
Patients with chronic kidney disease (CKD) are at increased risk of cardiovascular mortality. Lipid disorders, a constant feature of CKD, might contribute to this state. The aim of this study was to evaluate n-3 polyunsaturated fatty acids (PUFA) composition in CKD patients treated with dialysis, in comparison to the general population and to assess possible associations between the n-3 PUFA profile and anthropometric variables. Thirty-three prevalent dialysis patients were studied and compared with an age- and sex-adjusted control group of 22 patients...
November 2017: Renal Failure
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