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https://www.readbyqxmd.com/read/27896520/early-perfusion-mri-predicts-survival-outcome-in-patients-with-recurrent-glioblastoma-treated-with-bevacizumab-and-carboplatin
#1
Iwan E Bennett, Kathryn M Field, Christopher M Hovens, Bradford A Moffat, Mark A Rosenthal, Katharine Drummond, Andrew H Kaye, Andrew P Morokoff
Bevacizumab, an anti-angiogenic agent, is FDA-approved for use in patients with recurrent glioblastoma multiforme (rGBM). The radiologic evaluation of tumor response to bevacizumab is complex and there is no validated method of monitoring tumor vascularity during therapy. We evaluated perfusion-weighted MR imaging (PWI) in our cohort of patients enrolled in the CABARET trial, which examined the effectiveness of bevacizumab with or without carboplatin in patients with rGBM. Pre-treatment and early follow-up (4- and 8-week) PWI were used to calculate relative cerebral blood volume (rCBV) histogram statistics of the contrast-enhancing and FLAIR hyperintense tumor volumes...
November 28, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27895495/predictive-values-of-diffusion-weighted-imaging-and-perfusion-weighted-imaging-in-evaluating-the-efficacy-of-transcatheter-arterial-chemoembolization-for-hepatocellular-carcinoma
#2
Min Lin, Man-Man Tian, Wei-Ping Zhang, Li Xu, Ping Jin
This study explored the predictive values of diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) in evaluating the efficacy of transcatheter arterial chemoembolization (TACE) for patients with hepatocellular carcinoma (HCC). A total of 118 HCC patients treated with TACE were selected from April 2013 to November 2015. T1-weighted imaging (T1WI)/T2-weighted imaging (T2WI), DWI, and PWI were performed on all patients before and after TACE. Efficacy was evaluated according to modified Response Evaluation Criteria in Solid Tumors 1...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27857749/erythropoietin-reduces-apoptosis-of-brain-tissue-cells-in-rats-after-cerebral-ischemia-reperfusion-injury-a-characteristic-analysis-using-magnetic-resonance-imaging
#3
Chun-Juan Jiang, Zhong-Juan Wang, Yan-Jun Zhao, Zhui-Yang Zhang, Jing-Jing Tao, Jian-Yong Ma
Some in vitro experiments have shown that erythropoietin (EPO) increases resistance to apoptosis and facilitates neuronal survival following cerebral ischemia. However, results from in vivo studies are rarely reported. Perfusion-weighted imaging (PWI) and diffusion-weighted imaging (DWI) have been applied successfully to distinguish acute cerebral ischemic necrosis and penumbra in living animals; therefore, we hypothesized that PWI and DWI could be used to provide imaging evidence in vivo for the conclusion that EPO could reduce apoptosis in brain areas injured by cerebral ischemia/reperfusion...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27823971/combined-use-of-susceptibility-weighted-magnetic-resonance-imaging-sequences-and-dynamic-susceptibility-contrast-perfusion-weighted-imaging-to-improve-the-accuracy-of-the-differential-diagnosis-of-recurrence-and-radionecrosis-in-high-grade-glioma-patients
#4
Tae-Hyung Kim, Tae Jin Yun, Chul-Kee Park, Tae Min Kim, Ji-Hoon Kim, Chul-Ho Sohn, Jae Kyung Won, Sung-Hye Park, Il Han Kim, Seung Hong Choi
Purpose was to assess predictive power for overall survival (OS) and diagnostic performance of combination of susceptibility-weighted MRI sequences (SWMRI) and dynamic susceptibility contrast (DSC) perfusion-weighted imaging (PWI) for differentiation of recurrence and radionecrosis in high-grade glioma (HGG). We enrolled 51 patients who underwent radiation therapy or gamma knife surgeryfollowed by resection for HGG and who developed new measurable enhancement more than six months after complete response. The lesions were confirmed as recurrence (n = 32) or radionecrosis (n = 19)...
November 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27812502/comparison-of-unsupervised-classification-methods-for-brain-tumor-segmentation-using-multi-parametric-mri
#5
N Sauwen, M Acou, S Van Cauter, D M Sima, J Veraart, F Maes, U Himmelreich, E Achten, S Van Huffel
Tumor segmentation is a particularly challenging task in high-grade gliomas (HGGs), as they are among the most heterogeneous tumors in oncology. An accurate delineation of the lesion and its main subcomponents contributes to optimal treatment planning, prognosis and follow-up. Conventional MRI (cMRI) is the imaging modality of choice for manual segmentation, and is also considered in the vast majority of automated segmentation studies. Advanced MRI modalities such as perfusion-weighted imaging (PWI), diffusion-weighted imaging (DWI) and magnetic resonance spectroscopic imaging (MRSI) have already shown their added value in tumor tissue characterization, hence there have been recent suggestions of combining different MRI modalities into a multi-parametric MRI (MP-MRI) approach for brain tumor segmentation...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27807223/alcohol-use-and-mental-health-conditions-among-black-college-males-do-those-attending-postsecondary-minority-institutions-fare-better-than-those-at-primarily-white-institutions
#6
Adam E Barry, Zachary Jackson, Daphne C Watkins, Janelle R Goodwill, Haslyn E R Hunte
While there is a sizeable body of research examining the association between alcohol use and mental health conditions among college students, there are sparse investigations specifically focusing on these associations among Black college students. This is concerning given Black college students face different stressors compared with their non-Black peers. Black males appear especially at risk, exhibiting increased susceptibility to mental health issues and drinking in greater quantities and more frequently than Black females...
November 2, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27760656/-analysis-on-clinical-features-and-functional-mri-of-mitochondrial-encephalomyopathy-with-lactic-acidosis-and-stroke-like-episodes
#7
Y H Shi, J H Zhao, J L Song, Y J Li, K Liang
Objective: To explore the clinical and perfusion weighted imaging (PWI) characteristics of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) in order to improve the early diagnosis rate. Methods: Clinical and imaging data of 46 patients with final diagnosis of MELAS treated in Henan Province People's Hospital from January 2012 to June 2016 were collected. Results: Patients presented with symptoms of epilepsy, hemiplegia, language disorders, and decreased visual acuity and so on...
October 11, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27744467/perfusion-weighted-imaging-in-the-assessment-of-the-pathology-and-outcomes-of-lateral-medullary-infarction
#8
Dao P Zhang, Hong T Zhang, Suo Yin, Fu L Yan
This series case report aimed to elucidate the underlying pathology and outcomes of lateral medullary infarction (LMI) using perfusion weighted imaging (PWI). Four patients were diagnosed with LMI based on high-field diffusion-weighted magnetic resonance imaging (MRI-DWI) and PWI. The national institutes of health stroke scale (NIHSS) scores were recorded on days 1, 7, and 30, and the Barthel index was assessed on days 7 and 30. Three patients exhibited relative regional hypoperfusion of medullary lesion in the perfusion maps...
October 2016: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/27714665/picture-word-interference-is-a-stroop-effect-a-theoretical-analysis-and-new-empirical-findings
#9
Peter A Starreveld, Wido La Heij
The picture-word interference (PWI) paradigm and the Stroop color-word interference task are often assumed to reflect the same underlying processes. On the basis of a PRP study, Dell'Acqua et al. (Psychonomic Bulletin & Review, 14: 717-722, 2007) argued that this assumption is incorrect. In this article, we first discuss the definitions of Stroop- and picture-word interference. Next, we argue that both effects consist of at least four components that correspond to four characteristics of the distractor word: (1) response-set membership, (2) task relevance, (3) semantic relatedness, and (4) lexicality...
October 6, 2016: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/27686551/-preliminary-study-on-assessment-of-lexiscan-induced-blood-brain-barrier-opening-and-its-level-by-ct-perfusion-imaging
#10
Y Duan, B Q Yang, C C Chang, J Zhou, H Y Li, Z H Xu, Z W Wang, D Y Li
Objective: To evaluate the level of lexiscan-induced blood-brain barrier opening of healthy rabbits via CT perfusion weighted imaging (PWI) scan. Methods: Between November 2014 and May 2015, thirty New Zealand white rabbits were randomly assigned into three groups: the experimental group A1 which received one injection of lexiscan(1 ml/kg); the experimental group A2 which received three times injection of lexiscan(total dose: 1.5 ml/kg), finished within 15 minutes; the control group B which was injected the same volume normal saline(1 ml/kg), after 30 minutes, CT PWI scan was performed...
September 20, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27663412/challenges-and-outcomes-of-posterior-wall-isolation-for-ablation-of-atrial-fibrillation
#11
Prabhat Kumar, Ayotunde M Bamimore, Jennifer D Schwartz, Eugene H Chung, Anil K Gehi, Andy C Kiser, James P Hummel, J Paul Mounsey
BACKGROUND: The left atrial posterior wall (PW) often contains sites required for maintenance of atrial fibrillation (AF). Electrical isolation of the PW is an important feature of all open surgeries for AF. This study assessed the ability of current ablation techniques to achieve PW isolation (PWI) and its effect on recurrent AF. METHODS AND RESULTS: Fifty-seven consecutive patients with persistent or high-burden paroxysmal AF underwent catheter ablation, which was performed using an endocardial-only (30) or a hybrid endocardial-epicardial procedure (27)...
2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27659824/advanced-mr-imaging-in-hemispheric-low-grade-gliomas-before-surgery-the-indications-and-limits-in-the-pediatric-age
#12
Simona Gaudino, Rosellina Russo, Tommaso Verdolotti, Massimo Caulo, Cesare Colosimo
INTRODUCTION: Advanced magnetic resonance imaging (MRI) techniques is an umbrella term that includes diffusion (DWI) and diffusion tensor (DTI), perfusion (PWI), spectroscopy (MRS), and functional (fMRI) imaging. These advanced modalities have improved the imaging of brain tumors and provided valuable additional information for treatment planning. Despite abundant literature on advanced MRI techniques in adult brain tumors, few reports exist for pediatric brain ones, potentially because of technical challenges...
October 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27632171/using-brain-potentials-to-functionally-localise-stroop-like-effects-in-colour-and-picture-naming-perceptual-encoding-versus-word-planning
#13
Natalia Shitova, Ardi Roelofs, Herbert Schriefers, Marcel Bastiaansen, Jan-Mathijs Schoffelen
The colour-word Stroop task and the picture-word interference task (PWI) have been used extensively to study the functional processes underlying spoken word production. One of the consistent behavioural effects in both tasks is the Stroop-like effect: The reaction time (RT) is longer on incongruent trials than on congruent trials. The effect in the Stroop task is usually linked to word planning, whereas the effect in the PWI task is associated with either word planning or perceptual encoding. To adjudicate between the word planning and perceptual encoding accounts of the effect in PWI, we conducted an EEG experiment consisting of three tasks: a standard colour-word Stroop task (three colours), a standard PWI task (39 pictures), and a Stroop-like version of the PWI task (three pictures)...
2016: PloS One
https://www.readbyqxmd.com/read/27625381/aspects-alberta-stroke-program-early-ct-score-assessment-of-the-perfusion-diffusion-mismatch
#14
Louis Lassalle, Guillaume Turc, Marie Tisserand, Sylvain Charron, Pauline Roca, Stephanie Lion, Laurence Legrand, Myriam Edjlali, Olivier Naggara, Jean-François Meder, Jean-Louis Mas, Jean-Claude Baron, Catherine Oppenheim
BACKGROUND AND PURPOSE: Rapid and reliable assessment of the perfusion-weighted imaging (PWI)/diffusion-weighted imaging (DWI) mismatch is required to promote its wider application in both acute stroke clinical routine and trials. We tested whether an evaluation based on the Alberta Stroke Program Early CT Score (ASPECTS) reliably identifies the PWI/DWI mismatch. METHODS: A total of 232 consecutive patients with acute middle cerebral artery stroke who underwent pretreatment magnetic resonance imaging (PWI and DWI) were retrospectively evaluated...
October 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27600714/acetabular-wall-indices-help-to-distinguish-acetabular-coverage-in-asymptomatic-adults-with-varying-morphologies
#15
Lucas A Anderson, Mike B Anderson, Jill A Erickson, Jesse Chrastil, Christopher L Peters
BACKGROUND: The anterior wall index (AWI) and posterior wall index (PWI) have been proposed to quantify anterior and posterior acetabular coverage using AP pelvic radiographs. However, these indices have only been reported in symptomatic patients with apparent pathomorphologies (dysplasia, overcoverage, and retroversion) undergoing osteochondroplasty or reorientation osteotomy. QUESTIONS: (1) What are the ranges for AWI and PWI from measurements obtained on AP pelvic radiographs of asymptomatic senior athletes with well-functioning hips? (2) Is there a difference between the AWI and PWI in asymptomatic athletes with acetabular morphology consistent with acetabular dysplasia, overcoverage, and retroversion when compared with asymptomatic hips that do not meet the radiographic definitions for those morphologies (controls)? METHODS: Five hundred five athletes (998 asymptomatic native hips) were independently evaluated by two readers on AP pelvic radiographs for AWI and the PWI after excluding hips with prior surgery, inadequate radiographs, or poor function (modified Harris hip score < 80)...
September 6, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27569094/correlations-of-magnetic-resonance-perfusion-weighed-imaging-parameters-and-microvessel-density-in-meningioma
#16
Ruihua Shi, Tao Jiang, Lifang Si, Min Li
PURPOSE: To investigate the correlations of magnetic resonance, perfusion-weighed imaging (PWI) parameters and microvessel density (MVD) in meningioma. METHODS: 48 patients with pathologically confirmed meningioma (grade I, 38 cases; grade II+III, 10 cases) completed preoperative routine magnetic resonance imaging (MRI) and PWI. The cerebral blood volume (CBV) map of solid tumor region and the mean of maximum relative cerebral blood volume (rCBV) were then calculated...
May 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27531989/technical-pitfalls-of-signal-truncation-in-perfusion-mri-of-glioblastoma
#17
Kelvin K Wong, Steve H Fung, Pamela Z New, Stephen T C Wong
Dynamic susceptibility contrast (DSC) perfusion-weighted imaging (PWI) is widely used in clinical settings for the radiological diagnosis of brain tumor. The signal change in brain tissue in gradient echo-based DSC PWI is much higher than in spin echo-based DSC PWI. Due to its exquisite sensitivity, gradient echo-based sequence is the preferred method for imaging of all tumors except those near the base of the skull. However, high sensitivity also comes with a dynamic range problem. It is not unusual for blood volume to increase in gene-mediated cytotoxic immunotherapy-treated glioblastoma patients...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27513207/ultrasound-harmonic-enhanced-imaging-using-eigenspace-based-coherence-factor
#18
Wei Guo, Yuanyuan Wang, Jinhua Yu
Tissue harmonic imaging (THI) utilizes harmonic signals generating within the tissue as the result of nonlinear acoustic wave propagation. With inadequate transmitting acoustic energy, THI is incapable to detect the small objects since poor harmonic signals have been generated. In most cases, high transmission energy cannot be guaranteed because of the imaging safety issue or specific imaging modality such as the plane wave imaging (PWI). Discrimination of small point targets such as calcification, however, is particularly important in the ultrasound diagnosis...
December 2016: Ultrasonics
https://www.readbyqxmd.com/read/27502573/application-of-diffusion-weighted-imaging-and-dynamic-susceptibility-contrast-perfusion-weighted-imaging-for-ganglioglioma-in-adults-comparison-study-with-oligodendroglioma
#19
Seunghyun Lee, Tae Jin Yun, Koung Mi Kang, Jung Hyo Rhim, Chul-Kee Park, Tae Min Kim, Sung-Hye Park, Il Han Kim, Seung Hong Choi
BACKGROUND AND PURPOSE: To evaluate diffusion-weighted imaging (DWI) and dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) of ganglioglioma (GG) compared with oligodendroglioma (ODG). MATERIALS AND METHODS: We enrolled 36 patients with histopathologically confirmed GG (12 patients) or ODG (24 patients). The volumetric analyses of normalized ADC (nADC) and normalized CBV (nCBV) maps, tumor volume, and ratio of enhancing portion compared to the tumor volume were performed...
October 2016: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/27502247/mr-perfusion-weighted-imaging-in-the-evaluation-of-high-grade-gliomas-after-treatment-a-systematic-review-and-meta-analysis
#20
Praneil Patel, Hediyeh Baradaran, Diana Delgado, Gulce Askin, Paul Christos, Apostolos John Tsiouris, Ajay Gupta
BACKGROUND: Distinction between tumor and treatment related changes is crucial for clinical management of patients with high-grade gliomas. Our purpose was to evaluate whether dynamic susceptibility contrast-enhanced (DSC) and dynamic contrast enhanced (DCE) perfusion-weighted imaging (PWI) metrics can effectively differentiate between recurrent tumor and posttreatment changes within the enhancing signal abnormality on conventional MRI. METHODS: A comprehensive literature search was performed for studies evaluating PWI-based differentiation of recurrent tumor and posttreatment changes in patients with high-grade gliomas (World Health Organization grades III and IV)...
August 8, 2016: Neuro-oncology
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