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https://www.readbyqxmd.com/read/29764622/absolute-cbv-for-the-differentiation-of-recurrence-and-radionecrosis-of-brain-metastases-after-gamma-knife-radiotherapy-a-comparison-with-relative-cbv
#1
B Wang, B Zhao, Y Zhang, M Ge, P Zhao, Na Sun, C Li, Q Pang, S Xu, Y Liu
AIM: To investigate the efficiency of absolute cerebral blood volume (CBV) in the differentiation of tumour recurrence (TR) and radionecrosis (RN) in brain metastases (BM) and to evaluate the performance of absolute CBV compared to relative CBV (rCBV). MATERIALS AND METHODS: Between March 2015 and June 2017, 46 patients with BM underwent quantitative dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) because new enhancement had been demonstrated in irradiated lesions after gamma knife radiotherapy...
May 12, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29754597/re-wired-treatment-and-peer-support-for-men-who-have-sex-with-men-who-use-methamphetamine
#2
Kent Burgess, Garth Parkhill, Jeremy Wiggins, Simon Ruth, Mark Stoovè
Background This paper examines a methamphetamine treatment and peer support program for gay men and other men who have sex with men (MSM) who use methamphetamine. Australian MSM use illicit drugs including methamphetamine at significantly higher rates than the broader community.1,2 Methamphetamine rates are higher again amongst HIV positive MSM. Methamphetamine in the MSM community is associated with sexual activity and may be associated with psychosocial harms including risk of the transmission of HIV and sexually transmissible infections...
April 2018: Sexual Health
https://www.readbyqxmd.com/read/29750417/hits-clip-reveals-sex-differential-rna-binding-and-alterative-splicing-regulation-of-srm160-in-drosophila
#3
Chen Qiu, Yu Zhang, Yu-Jie Fan, Ting-Lin Pang, Yan Su, Shuai Zhan, Yong-Zhen Xu
Serine/arginine (SR)-rich proteins are critical for the regulation of alternative splicing (AS), which generates multiple mRNA isoforms from one gene and provides protein diversity for cell differentiation and tissue development. Genetic evidence suggests that Drosophila genital-specific overexpression of SR-related nuclear matrix protein of 160 kDa (SRm160), an SR protein with a PWI RNA-binding motif, causes defective development only in male flies and results in abnormal male genital structures and abnormal testis...
May 10, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29748200/extent-of-microstructural-tissue-damage-correlates-with-hemodynamic-failure-in-high-grade-carotid-occlusive-disease-an-mri-study-using-quantitative-t2-and-dsc-perfusion
#4
A Seiler, R Deichmann, U Nöth, A Lauer, W Pfeilschifter, O C Singer, M Wagner
BACKGROUND AND PURPOSE: Chronic hemodynamic impairment in high-grade carotid occlusive disease is thought to cause microstructural abnormalities that might be subclinical or lead to subtle symptoms including cognitive impairment. Quantitative MR imaging allows assessing pathologic structural changes beyond macroscopically visible tissue damage. In this study, high-resolution quantitative T2 mapping combined with DSC-based PWI was used to investigate quantitative T2 changes as a potential marker of microstructural damage in relation to hemodynamic impairment in patients with unilateral high-grade carotid occlusive disease...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29742722/arterial-spin-labeling-mr-imaging-aids-to-identify-cortical-venous-drainage-of-dural-arteriovenous-fistulas
#5
Ji Hee Kang, Tae Jin Yun, Jong Kook Rhim, Young Dae Cho, Dong Hyun Yoo, Roh-Eul Yoo, Koung Mi Kang, Seung Hong Choi, Ji-Hoon Kim, Chul-Ho Sohn, Moon Hee Han
Cortical venous drainage (CVD) increases the probability of intracranial hemorrhage and mortality rate of dural arteriovenous fistulas (DAVF). Although digital subtraction angiography (DSA) is the most accurate method to determine CVD in DAVFs, this modality has limitations due to its invasive nature and radiation issues. The purpose of this study was to evaluate the diagnostic utility of arterial spin-labeling perfusion-weighted images (ASL-PWI) to identify CVD in patients with DAVF.The Institutional Review Board of our hospital approved this retrospective study...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29696532/quantitative-dynamic-susceptibility-contrast-perfusion-weighted-imaging-guided-customized-gamma-knife-re-irradiation-of-recurrent-high-grade-gliomas
#6
Bao Wang, Peng Zhao, Yi Zhang, Mingxu Ge, Chuanjin Lan, Chuanting Li, Qi Pang, Shangchen Xu, Yingchao Liu
INTRODUCTION: Treatment of recurrent high-grade gliomas (rHGG) has always been challenging. This study aimed to explore the treatment effect of quantitative dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI)-guided gamma knife radiosurgery (GKRS) on rHGG. METHODS: Between April 2014 and July 2016, 26 consecutive patients were treated by quantitative DSC-PWI-guided GKRS as salvage treatment for rHGG. The gross tumor volume (GTV) was defined as the high perfusion area on absolute cerebral blood volume maps, with a cutoff value of 22 ml/100 g...
April 26, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29676844/differentiation-of-brain-infection-from-necrotic-glioblastoma-using-combined-analysis-of-diffusion-and-perfusion-mri
#7
Sanjeev Chawla, Sumei Wang, Suyash Mohan, MacLean Nasrallah, Gaurav Verma, Steven Brem, Donald M O'Rourke, Ronald L Wolf, Harish Poptani, S Ali Nabavizadeh
BACKGROUND: Accurate differentiation of brain infections from necrotic glioblastomas (GBMs) may not always be possible on morphologic MRI or on diffusion tensor imaging (DTI) and dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) if these techniques are used independently. PURPOSE: To investigate the combined analysis of DTI and DSC-PWI in distinguishing brain injections from necrotic GBMs. STUDY TYPE: Retrospective. POPULATION: Fourteen patients with brain infections and 21 patients with necrotic GBMs...
April 20, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29674415/noninvasive-assessment-of-hemodynamic-stress-distribution-after-indirect-revascularization-for-pediatric-moyamoya-vasculopathy
#8
D Tortora, M Severino, M Pacetti, G Morana, M M Mancardi, V Capra, A Cama, M Pavanello, A Rossi
BACKGROUND AND PURPOSE: Indirect revascularization surgery is an effective treatment in children with Moyamoya vasculopathy. In the present study, we hypothesized that DSC-PWI may reliably assess the evolution of CBF-related parameters after revascularization surgery, monitoring the outcome of surgical pediatric patients with Moyamoya vasculopathy. Thus, we aimed to evaluate differences in DSC-PWI parameters, including the hemodynamic stress distribution, in surgical and nonsurgical children with Moyamoya vasculopathy and to correlate them with long-term postoperative outcome...
April 19, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29658889/cross-correlation-analysis-of-pulse-wave-propagation-in-arteries-i-in-vitro-i-validation-and-i-in-vivo-i-feasibility
#9
Pierre Nauleau, Iason Zacharias Apostolakis, Matthew McGarry, Elisa E Konofagou
The stiffness of the arteries is known to be an indicator of the progression of various cardiovascular diseases. Clinically, the pulse wave velocity (PWV) is used as a surrogate for the arterial stiffness. Pulse Wave Imaging (PWI) is a non-invasive, ultrasound-based imaging technique capable of mapping the motion of the vessel walls allowing local assessment of the arterial properties. Conventionally, a distinctive feature of the displacement wave (e.g. the 50% upstroke) is tracked across the map to estimate the PWV...
April 16, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29621874/psychosocial-health-of-disease-free-breast-cancer-survivors-compared-with-matched-non-cancer-controls
#10
Boyoung Park, Moo Hyun Lee, Sun-Young Kong, Eun Sook Lee
Purpose: The present study investigated the psychosocial health of disease-free breast cancer survivors who receive health examinations compared to matched non-cancer controls in a community setting. Materials and Methods: We used baseline data from the Health Examinee cohort, which is composed of subjects participating in health. The disease-free breast cancer survivors were defined as those who were ≥2 years from initial diagnosis of breast cancer who had completed treatment...
April 5, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29619520/differentiation-between-primary-cns-lymphoma-and-glioblastoma-qualitative-and-quantitative-analysis-using-arterial-spin-labeling-mr-imaging
#11
Sung-Hye You, Tae Jin Yun, Hye Jeong Choi, Roh-Eul Yoo, Koung Mi Kang, Seung Hong Choi, Ji-Hoon Kim, Chul-Ho Sohn
OBJECTIVES: To evaluate the diagnostic performance of arterial spin labelling perfusion weighted images (ASL-PWIs) to differentiate primary CNS lymphoma (PCNSL) from glioblastoma (GBM). METHODS: ASL-PWIs of pathologically confirmed PCNSL (n = 21) or GBM (n = 93) were analysed. For qualitative analysis, tumours were visually scored into five categories based on ASL-CBF maps. For quantitative analysis, normalised CBF values were derived by contralateral grey matter (GM) in intra- and peritumoral areas (nCBFintratumoral and nCBFperitumoral , respectively)...
April 4, 2018: European Radiology
https://www.readbyqxmd.com/read/29557515/susceptibility-weighted-imaging-predicts-infarct-size-and-early-stage-clinical-prognosis-in-acute-ischemic-stroke
#12
Song Luo, Lijuan Yang, Yanfei Luo
Susceptibility-weighted imaging (SWI) is a non-invasive technique that can reveal venous structures and iron in the brain. This retrospective study evaluated SWI, relative to other imaging techniques, for determining cerebral infarct size and early-stage clinical prognosis in patients with acute ischemic stroke. Within 3 days after onset, 22 patients with acute ischemic stroke underwent SWI, diffusion-weighted imaging (DWI), perfusion-weighted imaging (PWI), fluid-attenuated inversion recovery (FLAIR), and magnetic resonance angiography (MRA)...
March 20, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29555872/can-diffusion-and-perfusion-weighted-imaging-alone-accurately-triage-anterior-circulation-acute-ischemic-stroke-patients-to-endovascular-therapy
#13
Dylan N Wolman, Michael Iv, Max Wintermark, Gregory Zaharchuk, Michael P Marks, Huy M Do, Robert L Dodd, Gregory W Albers, Maarten G Lansberg, Jeremy J Heit
BACKGROUND AND PURPOSE: Acute ischemic stroke (AIS) patients who benefit from endovascular treatment have a large vessel occlusion (LVO), small core infarction, and salvageable brain. We determined if diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) alone can correctly identify and localize anterior circulation LVO and accurately triage patients to endovascular thrombectomy (ET). MATERIALS AND METHODS: This retrospective cohort study included patients undergoing MRI for the evaluation of AIS symptoms...
March 19, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29550688/is-adaptive-control-in-language-production-mediated-by-learning
#14
Michael Freund, Nazbanou Nozari
Recent work using the Picture Word Interference (PWI) paradigm has revealed that language production, similar to non-verbal tasks, shows a robust Congruency Sequence Effect (CSE), defined as a decreased congruency effect following incongruent trials. Although CSE is considered an index of adaptive control, its mechanism is debated. In two experiments, we tested the predictions of a learning model of adaptive control in production, using a task-switching paradigm fully balanced to evaluate CSE on a PWI trial as a function of the congruency of a 2-back PWI trial (within-task CSE), as well as a 1-back trial belonging to a different task (cross-task CSE)...
March 15, 2018: Cognition
https://www.readbyqxmd.com/read/29510293/comparison-of-o-2-18-f-fluoroethyl-l-tyrosine-positron-emission-tomography-and-perfusion-weighted-magnetic-resonance-imaging-in-the-diagnosis-of-patients-with-progressive-and-recurrent-glioma-a-hybrid-positron-emission-tomography-magnetic-resonance-study
#15
COMPARATIVE STUDY
Antoine Verger, Christian P Filss, Philipp Lohmann, Gabriele Stoffels, Michael Sabel, Hans-J Wittsack, Elena Rota Kops, Norbert Galldiks, Gereon R Fink, Nadim J Shah, Karl-Josef Langen
OBJECTIVE: To compare the diagnostic performance of O-(2-18 F-fluoroethyl)-L-tyrosine (18 F-FET) positron emission tomography (PET) and perfusion-weighted magnetic resonance imaging (PWI) for the diagnosis of progressive or recurrent glioma. METHODS: Thirty-two pretreated gliomas (25 progressive or recurrent tumors, 7 treatment-related changes) were investigated with 18 F-FET PET and PWI via a hybrid PET/magnetic resonance scanner. Volumes of interest with a diameter of 16 mm were centered on the maximum of abnormality in the tumor area in PET and PWI maps (relative cerebral blood volume, relative cerebral blood flow, mean transit time) and the contralateral unaffected hemisphere...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29501465/the-effect-of-atrial-fibrillation-ablation-techniques-on-p-wave-duration-and-p-wave-dispersion
#16
Guy O Furniss, Dimitrios Panagopoulos, Sadeek Kanoun, Edward J Davies, David R Tomlinson, Guy A Haywood
BACKGROUND: A reduction in surface electrocardiogram (ECG) P wave duration and dispersion is associated with improved outcomes in atrial fibrillation ablation. We investigated the effects of different ablation strategies on P wave duration and dispersion, hypothesising that extensive left atrial (LA) ablation with left atrial posterior wall isolation would give a greater reduction in P wave duration than more limited ablation techniques. METHODS: A retrospective analysis of ECGs from patients who have undergone atrial fibrillation (AF) ablation was performed and pre-procedural sinus rhythm ECGs were compared with the post procedure ECGs...
February 14, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29500071/transient-regional-cerebral-hypoperfusion-during-a-paroxysmal-hemiplegic-event-in-glut1-deficiency-syndrome
#17
Mohamed Almuqbil, Michael J Rivkin, Masanori Takeoka, Edward Yang, Lance H Rodan
GLUT1 deficiency syndrome (GLUT1DS) is a well described neurometabolic disorder that results from impaired glucose transport into the central nervous system. GLUT1DS classically presents with infantile-onset epilepsy, progressive microcephaly, developmental delay, ataxia, dystonia, and spasticity, but a minority of patients may manifest with paroxysmal non-epileptic phenomena including hemiparesis (Wang et al., 2002). We report for the first time cerebral perfusion changes during an acute episode of hemiparesis in a 9 year old child with GLUT1DS...
May 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29476217/monitoring-cerebral-blood-flow-change-through-use-of-arterial-spin-labelling-in-acute-ischaemic-stroke-patients-after-intra-arterial-thrombectomy
#18
Roh-Eul Yoo, Tae Jin Yun, Dong Hyun Yoo, Young Dae Cho, Hyun-Seung Kang, Byung-Woo Yoon, Keun-Hwa Jung, Koung Mi Kang, Seung Hong Choi, Ji-Hoon Kim, Chul-Ho Sohn
OBJECTIVES: To evaluate the ability of arterial spin labelling perfusion-weighted imaging (ASL-PWI) to identify reperfusion status and to predict the early neurological outcome of acute ischaemic stroke patients after intra-arterial (IA) thrombectomy. METHODS: A total of 51 acute ischaemic stroke patients who underwent IA thrombectomy were retrospectively reviewed. Asymmetrical index before and after IA thrombectomy (AICBFpre and AICBFpost ) and volume ratio of the reperfused territory to the baseline perfusion abnormality (reperfusion volume ratio) were calculated on ASL-PWI...
February 23, 2018: European Radiology
https://www.readbyqxmd.com/read/29423079/therapeutic-effect-of-nerve-growth-factor-on-canine-cerebral-infarction-evaluated-by-mri
#19
Yong Wang, Hui Zhang, Zhe Wang, Huaijun Liu, Xin Tian, Jian Yu, Chaoxu Chen
To explore therapeutic effect of nerve growth factor (NGF) on cerebral infarction by establishing canine middle cerebral artery occlusion (MCAO) infarct model. The magnetic resonance imaging (MRI) technology was used to study effects of NGF on cerebral infarction, and the results of MRI indexes (such as diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI)) were compared with the results of pathology, cell biology and molecular biology. The clinical manifestations of the canine infarction model treated by NGF were significantly improved within 7 days compared with control group...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29398151/differentiation-between-radiation-induced-brain-injury-and-glioma-recurrence-using-3d-pcasl-and-dynamic-susceptibility-contrast-enhanced-perfusion-weighted-imaging
#20
Yu-Lin Wang, Si Chen, Hua-Feng Xiao, Ying Li, Yan Wang, Gang Liu, Xin Lou, Lin Ma
PURPOSE: This study was performed to validate the efficacy of three-dimensional pseudocontinuous arterial spin labeling (pCASL) compared with dynamic susceptibility contrast-enhanced perfusion-weighted imaging (DSC-PWI) in distinguishing radiation-induced brain injury from glioma recurrence in patients with glioma. METHODS: Both 3D pCASL and DSC-PWI were performed using a 3.0 Tesla scanner in 69 patients with previously resected and irradiated glioma who displayed newly developed abnormal contrast-enhanced lesions...
February 1, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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