Ann M Czyzewski, Lynda M McCaig, Michelle T Dohm, Lauren A Broering, Li-Juan Yao, Nathan J Brown, Maruti K Didwania, Jennifer S Lin, Jim F Lewis, Ruud Veldhuizen, Annelise E Barron
Acute lung injury (ALI) leads to progressive loss of breathing capacity and hypoxemia, as well as pulmonary surfactant dysfunction. ALI's pathogenesis and management are complex, and it is a significant cause of morbidity and mortality worldwide. Exogenous surfactant therapy, even for research purposes, is impractical for adults because of the high cost of current surfactant preparations. Prior in vitro work has shown that poly-N-substituted glycines (peptoids), in a biomimetic lipid mixture, emulate key biophysical activities of lung surfactant proteins B and C at the air-water interface...
May 1, 2018: Scientific Reports