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https://www.readbyqxmd.com/read/28730831/the-galanin-and-galanin-receptor-subtypes-its-regulatory-role-in-the-biological-and-pathological-functions
#1
J Šípková, I Kramáriková, S Hynie, V Klenerová
The multitalented neuropeptide galanin was first discovered 30 years ago but initially no biologic activity was found. Further research studies discovered the presence of galanin in the brain and some peripheral tissues, and galanin was identified as a modulator of neurotransmission in the central and peripheral nervous system. Over the last decade there were performed very intensive studies of the neuronal actions and also of nonneuronal actions of galanin. Other galanin family peptides have been described, namely galanin, galanin-like peptide, galanin-message associated peptide and alarin...
July 18, 2017: Physiological Research
https://www.readbyqxmd.com/read/28729711/an-ecological-and-digital-epidemiology-analysis-on-the-role-of-human-behavior-on-the-2014-chikungunya-outbreak-in-martinique
#2
Benjamin Roche, Béatrice Gaillard, Lucas Léger, Renélise Pélagie-Moutenda, Thomas Sochacki, Bernard Cazelles, Martine Ledrans, Alain Blateau, Didier Fontenille, Manuel Etienne, Frédéric Simard, Marcel Salathé, André Yébakima
Understanding the spatio-temporal dynamics of endemic infections is of critical importance for a deeper understanding of pathogen transmission, and for the design of more efficient public health strategies. However, very few studies in this domain have focused on emerging infections, generating a gap of knowledge that hampers epidemiological response planning. Here, we analyze the case of a Chikungunya outbreak that occurred in Martinique in 2014. Using time series estimates from a network of sentinel practitioners covering the entire island, we first analyze the spatio-temporal dynamics and show that the largest city has served as the epicenter of this epidemic...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729309/the-role-of-a-decision-support-smartphone-application-in-enhancing-community-health-volunteers-effectiveness-to-improve-maternal-and-newborn-outcomes-in-nairobi-kenya-quasi-experimental-research-protocol
#3
Pauline Bakibinga, Eva Kamande, Milka Omuya, Abdhalah K Ziraba, Catherine Kyobutungi
INTRODUCTION: Improving maternal and newborn survival remains major aspirations for many countries in the Global South. Slum settlements, a result of rapid urbanisation in many developing countries including Kenya, exhibit high levels of maternal and neonatal mortality. There are limited referral mechanisms for sick neonates and their mothers from the community to healthcare facilities with ability to provide adequate care. In this study, we specifically plan to develop and assess the added value of having community health volunteers (CHVs) use smartphones to identify and track mothers and children in a bid to reduce pregnancy-related complications and newborn deaths in the urban slums of Kamukunji subcounty in Nairobi, Kenya...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28729236/adolescents-perspectives-on-personalized-e-feedback-in-the-context-of-health-risk-behavior-screening-for-primary-care-qualitative-study
#4
Garret G Zieve, Laura P Richardson, Katherine Katzman, Heather Spielvogle, Sandy Whitehouse, Carolyn A McCarty
BACKGROUND: Electronic health screening tools for primary care present an opportunity to go beyond data collection to provide education and feedback to adolescents in order to motivate behavior change. However, there is limited research to guide feedback message development. OBJECTIVE: The aim of this study was to explore youth perceptions of and preferences for receiving personalized feedback for multiple health risk behaviors and reinforcement for health promoting behaviors from an electronic health screening tool for primary care settings, using qualitative methodology...
July 20, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28728603/the-effect-of-using-social-pressure-in-cover-letters-to-improve-retention-in-a-longitudinal-health-study-an-embedded-randomised-controlled-retention-trial
#5
Sarah Cotterill, Kelly Howells, Sarah Rhodes, Peter Bower
BACKGROUND: Retention of participants in cohort studies is important for validity. One way to promote retention is by sending a persuasive cover letter with surveys. The study aimed to compare the effectiveness of a covering letter containing social pressure with a standard covering letter on retention in a health cohort study. Social pressure involves persuading people to behave in a certain way by the promise that their actions will be made know to others. We implemented a mild form of social pressure, where the recipient was told that information about whether they responded to the current survey would be noted by the research team and printed on future correspondence from the research team to the recipient...
July 20, 2017: Trials
https://www.readbyqxmd.com/read/28728573/splicing-arrays-reveal-novel-rbm10-targets-including-smn2-pre-mrna
#6
Leslie C Sutherland, Philippe Thibault, Mathieu Durand, Elvy Lapointe, Jose M Knee, Ariane Beauvais, Irina Kalatskaya, Sarah C Hunt, Julie J Loiselle, Justin G Roy, Sarah J Tessier, Gustavo Ybazeta, Lincoln Stein, Rashmi Kothary, Roscoe Klinck, Benoit Chabot
BACKGROUND: RBM10 is an RNA binding protein involved in message stabilization and alternative splicing regulation. The objective of the research described herein was to identify novel targets of RBM10-regulated splicing. To accomplish this, we downregulated RBM10 in human cell lines, using small interfering RNAs, then monitored alternative splicing, using a reverse transcription-PCR screening platform. RESULTS: RBM10 knockdown (KD) provoked alterations in splicing events in 10-20% of the pre-mRNAs, most of which had not been previously identified as RBM10 targets...
July 20, 2017: BMC Molecular Biology
https://www.readbyqxmd.com/read/28728572/knowledge-attitudes-and-practices-on-malaria-transmission-in-mamfene-kwazulu-natal-province-south-africa-2015
#7
Pinky N Manana, Lazarus Kuonza, Alfred Musekiwa, Hluphi D Mpangane, Lizette L Koekemoer
BACKGROUND: In South Africa malaria is endemic in Mpumalanga, Limpopo and the north-eastern areas of KwaZulu-Natal provinces. South Africa has set targets to eliminate malaria by 2018 and research into complementary vector control tools such as the Sterile Insect Technique (SIT) is ongoing. It is important to understand community perceptions regarding malaria transmission and control interventions to enable development of community awareness campaign messages appropriate to the needs of the community...
July 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28728473/parents-views-on-childhood-obesity-qualitative-analysis-of-discussion-board-postings
#8
Jessica Appleton, Cathrine Fowler, Nicola Brown
BACKGROUND: Childhood obesity is an increasing concern for parents and health professionals alike. Parents' perception of obesity as a current health issue for their children is important for the everyday parenting and health choices parents make. As parents are frequently going online to seek and exchange information about parenting and child health, asynchronous online discussion forums provide an opportunity to investigate their perceptions and concerns. Understanding parents' perceptions, beliefs and attitudes is important in any childhood obesity prevention and intervention...
July 21, 2017: Contemporary Nurse
https://www.readbyqxmd.com/read/28728148/the-role-of-cytotoxic-chemotherapy-in-advanced-pancreatic-neuroendocrine-tumors
#9
Sebastian Krug, Thomas M Gress, Patrick Michl, Anja Rinke
BACKGROUND: Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms accounting for less than 5% of all pancreatic malignancies. These tumors are characterized by clinical and prognostical heterogeneity and are predominantly diagnosed in a metastatic stage. Cytotoxic chemotherapy, along with alkylating agents and antimetabolites as well as molecular targeted agents (everolimus, sunitinib), is used in the treatment of advanced PNETs. After the approval of lanreotide for unresectable PNETs, an additional therapeutic option has become available; however, the best sequence of therapies and patient stratification to different treatments remains challenging...
July 21, 2017: Digestion
https://www.readbyqxmd.com/read/28728090/remote-mood-monitoring-for-adults-with-bipolar-disorder-an-explorative-study-of-compliance-and-impact-on-mental-health-service-use-and-costs
#10
J Simon, K Budge, J Price, G M Goodwin, J R Geddes
BACKGROUND: Remote monitoring of mood disorders may be an effective and low resource option for patient follow-up, but relevant evidence remains very limited. This study explores real-life compliance and health services impacts of mood monitoring among patients with bipolar disorder in the UK. METHODS: Patients with a diagnosis of bipolar disorder who were registered users of the True Colours monitoring system for at least 12months at study assessment were included in this retrospective cohort study (n=79)...
July 3, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28727596/intraoperative-acute-multivessel-coronary-vasospasm-in-cardiac-allograft-a-case-report
#11
Richard Sheu, Kathleen Berfield, Stephanie Jones, Jay Pal, G Burkhard Mackensen
We present a patient who developed acute intraoperative cardiac failure requiring open cardiac message immediately after uncomplicated heart transplantation. After successful resuscitation and establishment of extracorporeal membrane oxygenation, coronary angiography showed diffuse multivessel coronary vasospasm, which responded to intracoronary and IV administration of vasodilators. Cardiac function gradually improved and the patient was discharged home after a prolonged hospital course. Cardiac allograft dysfunction associated with coronary vasospasm immediately after heart transplantation has not previously been reported...
July 19, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28727577/nurses-exploring-the-spirituality-of-their-patients-with-cancer-participant-observation-on-a-medical-oncology-ward
#12
Jacqueline van Meurs, Wim Smeets, Kris C P Vissers, Marieke Groot, Yvonne Engels
BACKGROUND: Attention for spirituality should be an integral part of professionals' caregiving. Particularly, nurses caring for patients with cancer might have opportunities to give attention to this dimension. OBJECTIVE: The aim of this study was to gain insight in the way and extent to which nurses during daily caregiving observe and explore spiritual issues of hospitalized patients with cancer. METHODS: We performed an ethnographic study with participant observation...
July 19, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28727555/tid-introducing-and-benchmarking-an-event-delivery-system-for-brain-computer-interfaces
#13
Christian Breitwieser, Michele Tavella, Martijn Schreuder, Febo Cincotti, Robert Leeb, Gernot R Muller-Putz
In this paper, we present and analyze an event distribution system for brain-computer interfaces (BCIs). Events are commonly used to mark and describe incidents during an experiment and are therefore critical for later data analysis or immediate real-time processing. The presented approach, called TiD (Tools for brain-computer interaction - interface D), delivers messages in XML format via a bus-like system using TCP (transmission control protocol) connections or shared memory. A dedicated server dispatches TiD messages to distributed or local clients...
July 18, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28726596/getting-the-message-across-an-august-bank-holiday-long-ago
#14
Musheer Hussain, Edward Fisher, Robin Youngs, Jonathan Fishman
No abstract text is available yet for this article.
August 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28726454/attitude-roots-and-jiu-jitsu-persuasion-understanding-and-overcoming-the-motivated-rejection-of-science
#15
Matthew J Hornsey, Kelly S Fielding
There is a worryingly large chasm between scientific consensus and popular opinion. Roughly one third of Americans are skeptical that humans are primarily responsible for climate change; rates of some infectious diseases are climbing in the face of anti-immunization beliefs; and significant numbers of the population worldwide are antievolution creationists. It is easy to assume that resistance to an evidence-based message is a result of ignorance or failure to grasp evidence (the "deficit model" of science communication)...
July 2017: American Psychologist
https://www.readbyqxmd.com/read/28725914/vascular-complications-in-diabetes-old-messages-new-thoughts
#16
REVIEW
Josephine M Forbes, Amelia K Fotheringham
In parallel with the growing diabetes pandemic, there is an increasing burden of micro- and macrovascular complications, occurring in the majority of patients. The identification of a number of synergistic accelerators of disease, providing therapeutic pathways, has stabilised the incidence of complications in most western nations. However, the primary instigators of diabetic complications and, thus, prevention strategies, remain elusive. This has necessitated a refocus on natural history studies, where tissue and plasma samples are sequentially taken to determine when and how disease initiates...
July 19, 2017: Diabetologia
https://www.readbyqxmd.com/read/28725453/development-of-an-implementation-intention-based-intervention-to-change-children-s-and-parent-carers-behaviour
#17
Karen Davies, Christopher J Armitage, Yin-Ling Lin, James Munro, Tanya Walsh, Peter Callery
BACKGROUND: Implementation intentions enable individuals to translate good intentions into action. Parents and children can find maintaining oral health difficult, as evidenced by the presence of tooth decay. This is a common condition in children in spite of being preventable through the use of regular tooth brushing, fluoride protection and avoiding sugar intake. Even when parents and children are positive about looking after the teeth, they can face challenges in maintaining consistent habits...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28725452/mapmysmoke-feasibility-of-a-new-quit-cigarette-smoking-mobile-phone-application-using-integrated-geo-positioning-technology-and-motivational-messaging-within-a-primary-care-setting
#18
Robert S Schick, Thomas W Kelsey, John Marston, Kay Samson, Gerald W Humphris
BACKGROUND: Approximately 11,000 people die in Scotland each year as a result of smoking-related causes. Quitting smoking is relatively easy; maintaining a quit attempt is a very difficult task with success rates for unaided quit attempts stubbornly remaining in the single digits. Pharmaceutical treatment can improve these rates by lowering the overall reward factor of nicotine. However, these and related nicotine replacement therapies do not operate on, or address, the spatial and contextual aspects of smoking behaviour...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28725411/choosing-a-mate-in-a-high-predation-environment-female-preference-in-the-fiddler-crab-uca-terpsichores
#19
Daniela M Perez, John H Christy, Patricia R Y Backwell
The interplay between a receiver's sensory system and a sender's courtship signals is fundamental to the operation of sexual selection. Male courtship signals that match a female receiver's preexisting perceptual biases can be favored yet the message they communicate is not always clear. Do they simply beacon the male's location or also indicate his quality? We explored this question in a species of fiddler crab Uca terpsichores that courts under elevated predation risk and that mates and breeds underground in the safety of males' burrows...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28724513/development-of-a-tailored-hiv-prevention-intervention-for-single-young-men-who-have-sex-with-men-who-meet-partners-online-protocol-for-the-mydex-project
#20
Jose Arturo Bauermeister, Ryan C Tingler, Michele Demers, Gary W Harper
BACKGROUND: New cases of human immunodeficiency virus (HIV) among young men who have sex with men (YMSM), aged 18 to 24, underscore the importance of developmentally-informed HIV programs for YMSM. We developed an online intervention focused on risk reduction strategies across different sexual partner types. Intervention activities focus on assisting YMSM reflect on their partner-seeking behaviors, develop sexual decision-making rules to reduce their HIV risks, and consider the adoption of HIV prevention behaviors...
July 19, 2017: JMIR Research Protocols
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