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https://www.readbyqxmd.com/read/29792343/plasma-initiated-graft-polymerization-as-an-immobilization-platform-for-metal-free-russian-propolis-ethanol-extracts-designed-specifically-for-biomaterials
#1
Ashwin Ambi, Carolina Vera, Nisharg Parikh, Naidel Perez, Anthony Lopez Rojas, Sanket Kumar, Christopher Stradford, Katherine Borbon, Julia Bryan, Christian Traba
The antibacterial and anti-biofilm activities of propolis have been intensively reported. However, the application of this folk remedy as a means to prevent biomedical implant contamination has yet to be completely evaluated. In response to the significant resistant and infectious attributes of biofilms, biomaterials engineered to possess specific chemical and physical properties were immobilized with metal free Russian propolis ethanol extracts (MFRPEE), a known antibacterial agent. The results obtained from this study begin to examine the application of MFRPEE as a novel alternative method for the prevention of medical and biomedical implant infections...
May 24, 2018: Biofouling
https://www.readbyqxmd.com/read/29760728/mesenchymal-stromal-cells-cultured-in-serum-from-heart-failure-patients-are-more-resistant-to-simulated-chronic-and-acute-stress
#2
Timo Z Nazari-Shafti, Zhiyi Xu, Andreas Matthäus Bader, Georg Henke, Kristin Klose, Volkmar Falk, Christof Stamm
Despite regulatory issues surrounding the use of animal-derived cell culture supplements, most clinical cardiac cell therapy trials using mesenchymal stromal cells (MSCs) still rely on fetal bovine serum (FBS) for cell expansion before transplantation. We sought to investigate the effect of human serum from heart failure patients (HFS) on cord blood MSCs (CB-MSCs) during short-term culture under regular conditions and during simulated acute and chronic stress. Cell survival, proliferation, metabolic activity, and apoptosis were quantified, and gene expression profiles of selected apoptosis and cell cycle regulators were determined...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29742663/a-simulator-for-breech-extraction-of-the-second-twin
#3
Meredith L Birsner
BACKGROUND: Breech extraction of a second twin is a skill useful for any health care provider planning on undertaking vaginal delivery of twins. However, training opportunities in this skill may be limited. METHOD: Using readily available supplies, a reusable model neoprene uterus can be constructed, as can a balloon model to simulate a fetus in the amniotic cavity. EXPERIENCE: The model allowed demonstration of skills expected of trainees and is easy to construct...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29738787/experimental-challenges-regarding-the-in-vitro-investigation-of-the-nanoparticle-biocorona-in-disease-states
#4
Sherleen Xue-Fu Adamson, Zhoumeng Lin, Ran Chen, Lisa Kobos, Jonathan Shannahan
Toxicological evaluation of nanoparticles (NPs) requires the utilization of in vitro techniques due to their number and diverse properties. Cell culture systems are often lacking in their ability to perform comparative toxicity assessment due to dosimetry issues and capacity to simulate in vivo environments. Upon encountering a physiological environment, NPs become coated with biomolecules forming a biocorona (BC), influencing function, biodistribution, and toxicity. Disease-induced alterations in the biological milieu can alter BC formation...
May 5, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29736154/decreased-il-33-production-contributes-to-trophoblast-cell-dysfunction-in-pregnancies-with-preeclampsia
#5
Hong Chen, Xiaobo Zhou, Ting-Li Han, Philip N Baker, Hongbo Qi, Hua Zhang
Preeclampsia (PE) is a life-threatening pregnancy complication which is related to aggradation of risk regarding fetal and maternal morbidity and mortality. Dysregulation of systemic inflammatory response and dysfunction of trophoblast cells have been proposed to be involved in the development and progression of PE. Some studies have demonstrated that interleukin-33 (IL-33) is an immunomodulatory cytokine that is associated with the immune regulation of tumor cells. However, little is known whether IL-33 and its receptor ST2/IL-1 R4 could regulate trophoblast cells, which are associated with the pathogenesis of PE...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29728048/impact-of-bioactive-peptide-motifs-on-molecular-structure-charging-and-non-fouling-properties-of-poly-ethylene-oxide-brushes
#6
Ognen Pop-Georgievski, Ralf Zimmermann, Ilya Kotelnikov, Vladimir Proks, Dirk Romeis, Jan Kucka, Anja Caspari, Frantisek Rypacek, Carsten Werner
Polymer layers capable of suppressing protein adsorption from biological media while presenting extracellular matrix derived peptide motifs offer valuable new options for biomimetic surface engineering. Herein, we provide detailed insights into physico-chemical changes induced in a non-fouling poly(ethylene oxide) (PEO) brush/polydopamine (PDA) system by incorporation of adhesion ligand (RGD) peptides. Brushes with high surface chain densities (σ ≥ 0.5 chains·nm-2 ) and pronounced hydrophilicity (water contact angles ≤ 10°) were prepared by end-tethering of hetero-bifunctional PEOs (Mn ~ 20000 g∙mol-1 ) to PDA-modified surfaces from a reactive melt...
May 4, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29700870/the-cost-effectiveness-of-first-trimester-screening-and-early-preventative-use-of-aspirin-in-women-at-high-risk-of-early-onset-pre-eclampsia
#7
Dayne Ortved, T Lee-Ann Hawkins, Jo-Ann Johnson, Jon Hyett, Amy Metcalfe
OBJECTIVE: Pre-eclampsia (PE) remains a leading cause of maternal and fetal morbidity and mortality. A first trimester screening algorithm predicting the risk of early onset PE has been developed and validated. Early prediction coupled with initiation of aspirin at 11 to 13 weeks in women identified as high risk is effective at reducing the prevalence of early onset PE. The aim of this study is to evaluate the cost-effectiveness of this first trimester screening program coupled with early use of low-dose aspirin in women at high risk of developing early onset PE versus current practice...
April 27, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29691766/characterization-of-the-hemodynamic-wall-shear-stresses-in-human-umbilical-vessels-from-normal-and-intrauterine-growth-restricted-pregnancies
#8
Shier Nee Saw, Yu Wei Poh, Dawn Chia, Arijit Biswas, Citra Nurfarah Zaini Mattar, Choon Hwai Yap
Significant reductions in blood flow and umbilical diameters were reported in pregnancies affected by intrauterine growth restriction (IUGR) from placental insufficiency. However, it is not known if IUGR umbilical blood vessels experience different hemodynamic wall shear stresses (WSS) compared to normal umbilical vessels. As WSS is known to influence vasoactivity and vascular growth and remodeling, which can regulate flow rates, it is important to study this parameter. In this study, we aim to characterize umbilical vascular WSS environment in normal and IUGR pregnancies, and evaluate correlation between WSS and vascular diameter, and gestational age...
April 24, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29630059/model-surgical-training-skills-acquisition-in-fetoscopic-laser-photocoagulation-of-monochorionic-diamniotic-twin-placenta-using-realistic-simulators
#9
Tuangsit Wataganara, Arundhati Gosavi, Katika Nawapun, Pradip D Vijayakumar, Nisarat Phithakwatchara, Mahesh Choolani, Lin Lin Su, Arijit Biswas, Citra N Z Mattar
Fetoscopic laser coagulation of arterio-venous anastomoses (AVA) in a monochorionic placenta is the standard of care for twin-twin transfusion syndrome (TTTS), but is technically challenging and can lead to significant complications. Acquiring and maintaining the necessary surgical skills require consistent practice, a critical caseload, and time. Training on realistic surgical simulators can potentially shorten this steep learning curve and enables several proceduralists to acquire procedure-specific skills simultaneously...
March 21, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29627736/regression-models-to-predict-the-behavior-of-the-coefficient-of-friction-of-aisi-316l-on-uhmwpe-under-iso-14243-3-conditions
#10
A L Garcia-Garcia, M Alvarez-Vera, L A Montoya-Santiyanes, I Dominguez-Lopez, J L Montes-Seguedo, J C Sosa-Savedra, J D O Barceinas-Sanchez
Friction is the natural response of all tribosystems. In a total knee replacement (TKR) prosthetic device, its measurement is hindered by the complex geometry of its integrating parts and that of the testing simulation rig operating under the ISO 14243-3:2014 standard. To develop prediction models of the coefficient of friction (COF) between AISI 316L steel and ultra-high molecular weight polyethylene (UHMWPE) lubricated with fetal bovine serum dilutions, the arthrokinematics and loading conditions prescribed by the ISO 142433: 2014 standard were translated to a simpler geometrical setup, via Hertz contact theory...
March 27, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29580376/high-throughput-non-invasive-prenatal-testing-for-fetal-rhesus-d-status-in-rhd-negative-women-not-known-to-be-sensitised-to-the-rhd-antigen-a-systematic-review-and-economic-evaluation
#11
Pedro Saramago, Huiqin Yang, Alexis Llewellyn, Ruth Walker, Melissa Harden, Stephen Palmer, Susan Griffin, Mark Simmonds
BACKGROUND: High-throughput non-invasive prenatal testing (NIPT) for fetal rhesus (D antigen) (RhD) status could avoid unnecessary treatment with routine anti-D immunoglobulin for RhD-negative women carrying a RhD-negative fetus, although this may lead to an increased risk of RhD sensitisations. OBJECTIVES: To systematically review the evidence on the diagnostic accuracy, clinical effectiveness and implementation of high-throughput NIPT and to develop a cost-effectiveness model...
March 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29516296/two-denominators-for-one-numerator-the-example-of-neonatal-mortality
#12
Quaker E Harmon, Olga Basso, Clarice R Weinberg, Allen J Wilcox
Preterm delivery is one of the strongest predictors of neonatal mortality. A given exposure may increase neonatal mortality directly, or indirectly by increasing the risk of preterm birth. Efforts to assess these direct and indirect effects are complicated by the fact that neonatal mortality arises from two distinct denominators (i.e. two risk sets). One risk set comprises fetuses, susceptible to intrauterine pathologies (such as malformations or infection), which can result in neonatal death. The other risk set comprises live births, who (unlike fetuses) are susceptible to problems of immaturity and complications of delivery...
March 7, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29495348/synthesis-characterization-and-in-vitro-study-of-synthetic-and-bovine-derived-hydroxyapatite-ceramics-a-comparison
#13
July Andrea Rincón-López, Jennifer Andrea Hermann-Muñoz, Astrid Lorena Giraldo-Betancur, Andrea De Vizcaya-Ruiz, Juan Manuel Alvarado-Orozco, Juan Muñoz-Saldaña
The physicochemical properties and biological behavior of sintered-bovine-derived hydroxyapatite (BHAp) are here reported and compared to commercial synthetic-HAp (CHAp). Dense ceramics were sintered for 2 h and 4 h at 1200 °C to investigate their microstructure-structure-in-vitro behavior relationship for both HAp ceramics. Densification was directly proportional to sintering time, showing a grain coarsening behavior with a greater effect on BHAp. Lattice parameters, crystallite size, cell volume and Ca / P ratio were determined by Rietveld refinement of X-ray diffraction (XRD) patterns using GSAS® ...
February 25, 2018: Materials
https://www.readbyqxmd.com/read/29492955/an-approximate-joint-model-for-multiple-paired-longitudinal-outcomes-and-time-to-event-data
#14
Angelo F Elmi, Katherine L Grantz, Paul S Albert
Joint modeling of multivariate paired longitudinal data and time-to-event data presents computational challenges that supersede full likelihood estimation due to the large dimensional random effects vector needed to capture correlation due to clustering with respect to pairs, subjects, and outcomes. We propose an alternative, computationally simpler approach to estimation of complex shared parameter models where missing data is imputed based on the Posterior Predictive Distribution from a Conditional Linear Model (CLM) approximation...
February 28, 2018: Biometrics
https://www.readbyqxmd.com/read/29467359/evaluation-of-a-portable-doppler-ultrasound-gating-device-for-fetal-cardiac-mr-imaging-initial-results-at-1-5t-and-3t
#15
Fabian Kording, Bjoern P Schoennagel, Manuela Tavares de Sousa, Kai Fehrs, Gerhard Adam, Jin Yamamura, Christian Ruprecht
PURPOSE: Fetal cardiac MRI has the potential to play an important role in the assessment of fetal cardiac pathologies, but it is up to now not feasible due to a missing gating method. The purpose of this work was the evaluation of Doppler ultrasound (DUS) for external fetal cardiac gating with regard to compatibility, functionality, and reliability. Preliminary results were assessed performing fetal cardiac MRI. METHODS: An MRI conditional DUS device was developed to obtain a gating signal from the fetal heart...
February 21, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29463201/effectiveness-of-gonacon-as-an-immunocontraceptive-in-colony-housed-cats
#16
Amy Fischer, Valerie Aw Benka, Joyce Briggs, Marc-Antoine Driancourt, Joanne Maki, Darcy So Mora, Kevin Morris, Kayla A Myers, Linda Rhodes, Lindsey M Vansandt, George Robert Weedon, Julie Wolf, Julie K Levy
Objectives Non-surgical contraceptive management of free-roaming cat populations is a global goal for public health and humane reasons. The objectives of this study were to measure the duration of contraception following a single intramuscular injection of a gonadotropin-releasing hormone-based vaccine (GonaCon) and to confirm its safe use in female cats living in colony conditions. Methods GonaCon (0.5 ml/cat) was administered intramuscularly to 20 intact female cats (queens), and saline was administered to 10 queens serving as sham-treated controls...
February 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29453123/an-experiential-model-of-education-introduced-to-improve-the-confidence-of-student-midwives-in-undertaking-second-stage-management-of-the-perineum-ssmp
#17
Teresa Arias, Kirstie Coxon
BACKGROUND AND OBJECTIVE: the limited availability of high quality evidence related to second stage management of the perineum (SSMP) combined with a perceived shift in UK practice towards a 'hands off' the perineum/fetal head approach are likely to have impacted significantly on student midwives' understanding of SSMP. This paper presents a classroom based educational session using low fidelity simulation, which was designed in response to student feedback and aimed to improve confidence in this skill...
April 2018: Midwifery
https://www.readbyqxmd.com/read/29447406/using-structural-equation-modelling-to-jointly-estimate-maternal-and-fetal-effects-on-birthweight-in-the-uk-biobank
#18
Nicole M Warrington, Rachel M Freathy, Michael C Neale, David M Evans
Background: To date, 60 genetic variants have been robustly associated with birthweight. It is unclear whether these associations represent the effect of an individual's own genotype on their birthweight, their mother's genotype, or both. Methods: We demonstrate how structural equation modelling (SEM) can be used to estimate both maternal and fetal effects when phenotype information is present for individuals in two generations and genotype information is available on the older individual...
February 13, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29440752/one-step-noninvasive-prenatal-testing-nipt-for-autosomal-recessive-homozygous-point-mutations-using-digital-pcr
#19
Mun Young Chang, Soyeon Ahn, Min Young Kim, Jin Hee Han, Hye-Rim Park, Han Kyu Seo, Jinsun Yoon, Seungmin Lee, Doo-Yi Oh, Changsoo Kang, Byung Yoon Choi
Previously, we introduced a noninvasive prenatal testing (NIPT) protocol for diagnosing compound heterozygous autosomal recessive point mutations via maternal plasma DNA and simulated control genomic DNA sampling based on fetal DNA fraction. In our present study, we have improved our NIPT protocol to make it possible to diagnose homozygous autosomal recessive point mutations without the need to acquire fetal DNA fraction. Moreover, chi-squared test and empirical statistical range based on the proportion of mutant allele reads among the total reads served as the gatekeeping method...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29420402/twenty-week-abortion-bans-on-pregnancies-with-a-congenital-diaphragmatic-hernia-a-cost-effectiveness-analysis
#20
Kimberley A Bullard, Brian L Shaffer, Karen S Greiner, Ashley E Skeith, Maria I Rodriguez, Aaron B Caughey
OBJECTIVE: To estimate the effect of 20-week abortion bans on maternal and consequent neonatal health outcomes and costs in the setting of fetal congenital diaphragmatic hernia. METHODS: A decision-analytic model was built using TreeAge software to evaluate the effect of a 20-week ban on abortion in a theoretical cohort of 921 women diagnosed with fetal congenital diaphragmatic hernia. Probabilities, utilities, and costs were derived from the literature. The cohort size was based on the annual rate of prenatal diagnoses of congenital diaphragmatic hernia and live births among the 20 states with bans...
March 2018: Obstetrics and Gynecology
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