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simulation fetal

Courtney Stanley Sundin, Lauren Bradham Mazac
Amniotic fluid embolism (AFE) is a rare but serious and potentially deadly complication of pregnancy that is unpreventable and unpredictable. Most AFE events occur during labor; however, approximately one third happen during the immediate postpartum period. Presentation is abrupt and thought to be an abnormal response to fetal materials entering maternal circulation through the placental insertion site. Care providers must recognize the signs and symptoms of AFE and react quickly in effort to treat potential complications...
October 13, 2016: MCN. the American Journal of Maternal Child Nursing
You Li, Dongwoon Hyun, Lotfi Abou-Elkacem, Juergen Willmann, Jeremy Dahl
Power Doppler (PD) imaging is a widely used technique for flow detection. Despite the wide use of Doppler ultrasound, limitations exist in the ability of Doppler ultrasound to assess slow flow in small-diameter vasculature, such as the maternal spiral arteries and fetal villous arteries of the placenta and focal liver lesions. The sensitivity of PD in small vessel detection is limited by the low signal produced by slow flow and the noise associated with small vessels. The noise sources include electronic noise, stationary or slowly moving tissue clutter, reverberation clutter, and off-axis scattering from tissue, among others...
October 10, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Yanfei Jia, Xiaodong Yang
Fetal electrocardiogram (FECG) extraction is very important procedure for fetal health assessment. In this article, we propose a fast one-unit independent component analysis with reference (ICA-R) that is suitable to extract the FECG. Most previous ICA-R algorithms only focused on how to optimize the cost function of the ICA-R and payed little attention to the improvement of cost function. They did not fully take advantage of the prior information about the desired signal to improve the ICA-R. In this paper, we first use the kurtosis information of the desired FECG signal to simplify the non-Gaussian measurement function and then construct a new cost function by directly using a nonquadratic function of the extracted signal to measure its non-Gaussianity...
2016: Computational and Mathematical Methods in Medicine
Wenjuan Sun, Baoxia Cui, Fanzhen Hong, Yongping Xu
In the present study, we established an ApoE-knockout mouse model of preeclampsia to examine the role of vascular endothelial injury associated with abnormal lipid metabolism in the pathogenesis of preeclampsia. To establish the ApoE-knockout homozygous (ApoE(-/-)) and heterozygous (ApoE(+/-)) mouse model, mice were mated with the same genotype and orbital blood on day 19 of conception was collected. The progeny mice were assigned into 3 groups: ApoE(-/), ApoE(+/-) and wild-type (WT) groups. Total cholesterol, triglyceride, low-density and high-density lipoprotein were measured in the serum at the end of conception...
October 2016: Experimental and Therapeutic Medicine
Xin Wang, Falk Poenisch, Narayan Sahoo, Ronald X Zhu, MingFwu Lii, Michael T Gillin, Jing Li, David Grosshans
This is a real case study to minimize the neutron dose equivalent (H) to a fetus using spot scanning proton beams with favorable beam energies and angles. Minimum neutron dose exposure to the fetus was achieved with iterative planning under the guidance of neutron H measurement. Two highly conformal treatment plans, each with three spot scanning beams, were planned to treat a 25-year-old pregnant female with aggressive recurrent chordoma of the base of skull who elected not to proceed with termination. Each plan was scheduled for delivery every other day for robust target coverage...
2016: Journal of Applied Clinical Medical Physics
Hadi Wiputra, Chang Quan Lai, Guat Ling Lim, Joel Jia Wei Heng, Lan Guo, Hwa Liang Leo, Sanah Merchant Soomar, Arijit Biswas, Citra Nurfarah Zaini Mattar, Choon Hwai Yap
0.6-1.9% of US children were born with congenital heart malformations. Clinical and animal studies suggests that abnormal blood flow forces might play a role in causing these malformation, highlighting the importance of understanding the fetal cardiovascular fluid mechanics. We performed Computational Fluid Dynamics simulations of the right ventricles, based on 4D ultrasound scans of three 20 weeks old normal human foetuses, to characterize their flow and energy dynamics. Peak intraventricular pressure gradients were found to be 0...
September 23, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Xiongbin Kang, Jun Xia, Yicong Wang, Huixin Xu, Haojun Jiang, Weiwei Xie, Fang Chen, Peng Zeng, Xuchao Li, Yifan Xie, Hongtai Liu, Guodong Huang, Dayang Chen, Ping Liu, Hui Jiang, Xiuqing Zhang
BACKGROUND: With the speedy development of sequencing technologies, noninvasive prenatal testing (NIPT) has been widely applied in clinical practice for testing for fetal aneuploidy. The cell-free fetal DNA (cffDNA) concentration in maternal plasma is the most critical parameter for this technology because it affects the accuracy of NIPT-based sequencing for fetal trisomies 21, 18 and 13. Several approaches have been developed to calculate the cffDNA fraction of the total cell-free DNA in the maternal plasma...
2016: PloS One
Laurice Bou Nemer, Dawn Kalin, Desiree Fiorentino, Jorge J Garcia, Christopher M Estes
OBJECTIVE: To develop and evaluate a simulation laboratory designed to stimulate learning and increase medical students' preparedness for an obstetrics and gynecology clinical clerkship. METHODS: Ninety-seven medical students participated in the games during their obstetrics and gynecology clerkship in 1 year. Using the resident-as-teacher model, students rotated through seven stations, each with a simulated obstetric task. Points were awarded at each station, and the student with the highest score won...
October 2016: Obstetrics and Gynecology
Angela K Shaddeau, Shad Deering
Shoulder dystocia is an unpredictable obstetric emergency that requires prompt interventions to ensure optimal outcomes. Proper technique is important but difficult to train given the urgent and critical clinical situation. Simulation training for shoulder dystocia allows providers at all levels to practice technical and teamwork skills in a no-risk environment. Programs utilizing simulation training for this emergency have consistently demonstrated improved performance both during practice drills and in actual patients with significantly decreased risks of fetal injury...
September 22, 2016: Clinical Obstetrics and Gynecology
E Codsi, J F Nitsche, M L Decker, B C Brost
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
Yuta Matsunaga, Ai Kawaguchi, Masanao Kobayashi, Shigetaka Suzuki, Shoichi Suzuki, Koichi Chida
The purposes of this study were (1) to compare the radiation doses for 320- and 80-row fetal-computed tomography (CT), estimated using thermoluminescent dosimeters (TLDs) and the ImPACT Calculator (hereinafter referred to as the "CT dosimetry software"), for a woman in her late pregnancy and her fetus and (2) to estimate the overlapped fetal radiation dose from a 320-row CT examination using two different estimation methods of the CT dosimetry software. The direct TLD data in the present study were obtained from a previous study...
September 19, 2016: Radiological Physics and Technology
B Li, D S Sahota, T T Lao, J Xu, S Q Hu, L Zhang, Q Y Liu, Q Sun, D Tang, R M Ma
OBJECTIVE: To assess the feasibility and performance of the first-trimester combined screening test for trisomy 21 in a resource-limited setting in mainland China. DESIGN: Prospective observational cohort study. SETTING: First Affiliated Hospital of Kunming Medical University, China. POPULATION: Ten thousand four hundred and forty-two pregnant women requesting first-trimester screening. METHODS: The combined screening test was performed from May 2012 to December 2014...
September 2016: BJOG: An International Journal of Obstetrics and Gynaecology
Chui-Yee Fong, Arijit Biswas, Walter Stunkel, Yap-Seng Chong, Ariff Bongso
The infants of mothers with gestational diabetes mellitus (GDM) have an increased risk of metabolic and cardiovascular disease. It has been difficult to study the direct effects of maternal hyperglycemia on the fetus because of inaccessibility of fetal tissues. The development of tissues that simulate the function of fetal organs using stem cell technology provides an unprecedented opportunity to study this disorder. Stem cells in the Wharton's jelly of the umbilical cord (hWJSCs), possess unique properties that are different from other stem cells...
September 12, 2016: Journal of Cellular Biochemistry
Michalis Mazonakis, Antonis Tzedakis, John Damilakis
This study estimated the fetal dose and risks from radiotherapy for breast cancer with 6 MV X-rays. Breast irradiation was simulated with the MCNP code using two mathematical phantoms corresponding to patients in the early and middle periods of pregnancy. Monte Carlo simulations were performed to determine the appropriate fetal shielding. For a 50-Gy tumor dose, the unshielded fetal dose reached up to 133.1 mGy. Fetal protection with a lead shield of dimensions 30 × 30 × 5 cm(3) placed besides the treatment couch resulted in maximum doses of 22...
September 9, 2016: Radiation Protection Dosimetry
J D O Barceinas-Sanchez, M Alvarez-Vera, L A Montoya-Santiyanes, I Dominguez-Lopez, A L Garcia-Garcia
The observation of tribological phenomena occurring in total knee replacement (TKR) simulators may be obscured by the intrinsic complexity of their operation: the dynamics and kinematics prescribed by the ISO 14243-3:2014 standard, and the geometry of the surfaces involved. On the other hand, evaluating the individual performance of the tribosystem elements may be carried out in simpler apparatuses. An experimental method is presented here, by means of which the arthrokinematics and loading conditions prescribed by the said standard are adapted to a ball-on-disc configuration in order to observe the behavior of the coefficient of friction along an entire walking cycle, using the contact point of an AISI 316L stainless steel ball rolling/sliding on an ultra-high molecular weight polyethylene (UHMWPE) disc, lubricated by a solution of fetal bovine serum, at 37°C...
August 30, 2016: Journal of the Mechanical Behavior of Biomedical Materials
F Auriault, L Thollon, J Pérès, M Behr
This study documents the development of adverse fetal outcome predictors dedicated to the analysis of road accidents involving pregnant women. To do so, a pre-existing whole body finite element model representative of a 50th percentile 26 weeks pregnant woman was used. A total of 8 accident scenarios were simulated with the model positioned on a sled. Each of these scenarios was associated to a risk of adverse fetal outcome based on results from real car crash investigations involving pregnant women from the literature...
September 2, 2016: Accident; Analysis and Prevention
Ladislav Krofta, Linda Havelková, Iva Urbánková, Michal Krčmář, Luděk Hynčík, Jaroslav Feyereisl
INTRODUCTION AND HYPOTHESIS: During vaginal delivery, the levator ani muscle (LAM) undergoes severe deformation. This stress can lead to stretch-related LAM injuries. The objective of this study was to develop a sophisticated MRI-based model to simulate changes in the LAM during vaginal delivery. METHODS: A 3D finite element model of the female pelvic floor and fetal head was developed. The model geometry was based on MRI data from a nulliparous woman and 1-day-old neonate...
August 25, 2016: International Urogynecology Journal
Xiani Yan, Jennifer A Kruger, Xinshan Li, Poul M F Nielsen, Martyn P Nash
Vaginal delivery is the primary cause of levator ani muscle injury, which is in turn the leading factor contributing to pelvic floor disorders including pelvic organ prolapse and urinary stress incontinence. Existing biomechanical models of childbirth have provided some understanding of pelvic floor function during delivery and have helped in the investigation of preventative strategies. The modeling frameworks for childbirth simulation are described with emphasis on (1) the recent advances in medical imaging quality and computational power; (2) improvements in the anatomical representation of the pelvic floor and fetal head; (3) more realistic boundary conditions for delivery; and (4) mechanical properties determined from experiments...
November 2016: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
Sascha R Ellington, Owen Devine, Jeanne Bertolli, Alma Martinez Quiñones, Carrie K Shapiro-Mendoza, Janice Perez-Padilla, Brenda Rivera-Garcia, Regina M Simeone, Denise J Jamieson, Miguel Valencia-Prado, Suzanne M Gilboa, Margaret A Honein, Michael A Johansson
Importance: Zika virus (ZIKV) infection during pregnancy is a cause of congenital microcephaly and severe fetal brain defects, and it has been associated with other adverse pregnancy and birth outcomes. Objective: To estimate the number of pregnant women infected with ZIKV in Puerto Rico and the number of associated congenital microcephaly cases. Design, Setting, and Participants: We conducted a modeling study from April to July 2016. Using parameters derived from published reports, outcomes were modeled probabilistically using Monte Carlo simulation...
October 1, 2016: JAMA Pediatrics
Jean Edgard Aupont, Ranjit Akolekar, Aurora Illian, Stratos Neonakis, Kypros H Nicolaides
OBJECTIVES: To investigate whether measurement of maternal serum placental growth factor (PLGF) at 19-24 weeks' gestation improves the performance of screening for stillbirths that is achieved by a combination of maternal factors, fetal biometry and uterine artery pulsatility index (UT-PI) and evaluate the performance of screening of this model for all stillbirths and those due to impaired placentation and unexplained or other causes. METHODS: This was a prospective screening study of 70,003 singleton pregnancies including 268 stillbirths, carried out in two phases...
August 18, 2016: Ultrasound in Obstetrics & Gynecology
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