keyword
MENU ▼
Read by QxMD icon Read
search

Atypical femur fractures

keyword
https://www.readbyqxmd.com/read/27926679/factors-associated-with-increased-healing-time-in-complete-femoral-fractures-after-long-term-bisphosphonate-therapy
#1
Hae-Seong Lim, Chong-Kwan Kim, Youn-Soo Park, Young-Wan Moon, Seung-Jae Lim, Sang-Min Kim
BACKGROUND: The purpose of this study was to analyze factors that affect healing time after operative treatment of complete femoral fractures associated with long-term use of bisphosphonates. In particular, we sought to determine surgically controllable factors related to fracture-healing time. METHODS: Ninety-nine consecutive patients (109 fractures) who had been surgically treated for a complete atypical femoral fracture were enrolled. All patients had a documented history of bisphosphonate therapy at the time of presentation, with an average duration of 7...
December 7, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27900455/bilateral-atypical-femur-fractures-without-bisphosphonate-exposure
#2
Lauren K Szolomayer, Izuchukwu K Ibe, Dieter M Lindskog
Atypical femur fractures have common radiographic features that set them apart from more typical higher-energy subtrochanteric femur fractures. They are noncomminuted, transverse fractures with medial spiking of the femoral cortex and increased lateral cortical thickness. These fractures have been associated in the literature with the use of bisphosphonate medications. This case describes bilateral atypical femur fractures in a patient with a medical history devoid of bisphosphonate use. We present his history, co-morbidities, and subsequent treatment...
November 30, 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27866217/osteonecrosis-of-the-jaw-onj-and-atypical-femoral-fracture-aff-in-an-osteoporotic-patient-chronically-treated-with-bisphosphonates
#3
A Sánchez, R Blanco
The aim of the study is to report the rare association of two complications of long-term treatment of osteoporosis with bisphosphonates in the same Caucasian elderly patient. A female patient of Italian descent, age 87 years, consulted in February 2013. She had a history of osteoporosis and had taken alendronate weekly for 7 years (1999-2006). Due to low back pain, an orthopedist had indicated i.v. zoledronic acid, 5 mg/year for 3 years (2006-2008). She received occasional supplements of ergocalciferol...
November 20, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27830385/atypical-femoral-fractures-in-italy-a-retrospective-analysis-in-a-large-urban-emergency-department-during-a-7-year-period-2007-2013
#4
Mario Pedrazzoni, Andrea Giusti, Giuseppe Girasole, Barbara Abbate, Ignazio Verzicco, Gianfranco Cervellin
The aim of this study was to determine the incidence of atypical femoral fractures (AFFs) seen in a large emergency department in Italy. It was a retrospective study of all men and women aged 40 years or older admitted to the Emergency Department of Parma University Hospital for a femoral fracture. Cases were identified in the hospital database with use of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code 820 or 821 or text strings. All the radiographic images of fractures not clearly identified as proximal or condylar were retrieved and evaluated by three independent reviewers...
November 9, 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27824547/atypical-femur-fractures-in-patients-treated-with-bisphosphonates-identification-management-and-prevention
#5
REVIEW
Judith Sarah Bubbear
Osteoporosis is a common condition with significant health care costs. First-line therapy is with bisphosphonates, which have proven anti-fracture efficacy. Around 10 years after the introduction of bisphosphonates reports began to be published of atypical femoral fractures (AFFs) that may be associated with this therapy. These fractures are associated with significant morbidity although lower mortality than the more common osteoporotic neck-of-femur fractures. A case definition has been described to allow identification of this class of fracture...
October 31, 2016: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/27812727/-atypical-subtrochanteric-femur-fracture-under-alendronate-therapy-in-spite-of-an-intramedullar-implant
#6
H-P Sobotta, T Gösling
There are a number of case reports about women undergoing long-term bisphosphonate therapy who have suffered an atypical subtrochanteric or femoral shaft fracture due to an inadequate trauma.The present case reports on a patient who underwent a subtrochanteric femur fracture with the inserted AO femur interlocking nail.
November 3, 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/27802096/novel-scoring-system-for-identifying-impending-complete-fractures-in-incomplete-atypical-femoral-fractures
#7
Byung-Woo Min, Kyung-Hoi Koo, Youn-Soo Park, Chang-Wug Oh, Seung-Jae Lim, Joon-Woo Kim, Kyung-Jae Lee, Young-Kyun Lee
CONTEXT: Although impending incomplete atypical femoral fractures (AFFs) require prophylactic fixation, there is still a lack of study on predicting complete fracture among the incomplete AFFs. OBJECTIVE: Our purposes are (1) to develop a scoring system to predict progression into complete fracture and (2) to evaluate its reliability and validity. DESIGN, SETTING, AND PATIENTS: We reviewed 46 incomplete AFFs in 44 patients, who did not undergo prophylactic fixation...
November 1, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27777917/adjuvant-teriparatide-therapy-for-surgical-treatment-of-femoral-fractures-does-it-work
#8
Jung Taek Kim, Hyung Jun Jeong, Soong Joon Lee, Hee Joong Kim, Jeong Joon Yoo
PURPOSE: Atypical femoral fracture (AFF), periprosthetic femoral fracture (PPFF) and femoral nonunion (FNU) are recalcitrant challenges for orthopedic surgeons. Teriparatide (TPTD) had been demonstrated to have anabolic effects on bone in various studies. We postulated that adjuvant TPTD after operation would enhance biologic stimulation for bone formation. We investigated (1) whether the adjuvant TPTD could achieve satisfactory union rate of surgically challenging cases such as displaced AFF, PPFF and FNU; (2) whether the adjuvant TPTD could promote development of abundant callus after surgical fixation; (3) whether the adjuvant TPTD had medically serious adverse effects...
September 2016: Hip & Pelvis
https://www.readbyqxmd.com/read/27731487/sequential-administration-of-alendronate-and-strontium-ranelate-histomorphometry-and-bone-biomechanics-in-ovariectomized-animals
#9
Diego H Díaz, Julieta A Rodas, Clarisa E Bozzini, Patricia M Mandalunis, Natalia D Escudero
Bisphosphonates are the first choice therapy for the pharmaco logical treatment of osteoporosis. Following reports of cases of bisphosphonaterelated osteonecrosis of the jaw and atypical femur fracture, the safety of longterm use of bisphosphonates has been evaluated, resulting in the proposal of strontium as an alternative drug. No experimental study using a sequential administration design has been reported to date. Hence, the aim of this study was to evaluate the effect on bone tissue of ovariectomized rats of administration of alendronate followed by strontium ranelate...
September 2016: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/27720510/anterolateral-femoral-bowing-and-loss-of-thigh-muscle-are-associated-with-occurrence-of-atypical-femoral-fracture-effect-of-failed-tension-band-mechanism-in-mid-thigh
#10
W C Shin, N H Moon, J H Jang, K Y Park, K T Suh
BACKGROUND: The purpose of this study was to characterize anterolateral bowing of the femur using X-rays and muscular atrophy in the mid-thigh using computed tomography (CT) in patients with atypical femoral fractures (AFFs). We then compared the results with those of an intertrochanteric fracture to understand whether these measures act as causative factors of AFFs. METHODS: From January 2009 to December 2015, 37 patients with complete AFF and 12 patients with incomplete AFF were enrolled in this study...
October 6, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27708978/teriparatide-for-the-rapid-resolution-of-delayed-healing-of-atypical-fractures-associated-with-long-term-bisphosphonate-use
#11
Silvina R Mastaglia, Gabriel Aguilar, Beatriz Oliveri
Bisphosphonates (BPs) are the most widely used drugs to treat osteoporosis. However, recent reports associated to long-term BPs use with atypical low-impact fractures and prodromal pain. It is estimated that 26% of the cases of atypical fractures associated with the long-term use of BPs show delayed healing or nonunion. Teriparatide [PTH1-34] (TPTD) is an anabolic drug shown to be effective in stimulating bone formation. The aim was to describe the course of a right diaphyseal femoral fracture sustained by a patient on long-term BPs treatment...
June 2016: Eur J Rheumatol
https://www.readbyqxmd.com/read/27682303/atypical-femur-fractures-patient-characteristics-and-results-of-intramedullary-nailing-for-a-series-of-21-patients
#12
S Subramanian, M J Parker
Atypical femoral fractures have been associated with long term use of bisphosphonates. Our study plan was to report the outcome of treatment for a series of -patients with an atypical femoral fracture and to compare the characteristics of those patients with a proximal femoral fracture. 21 atypical fractures were identified over a seven year period and these were compared with those of 2.547 hip fracture patients treated over the same time period at a single centre. The mean age of patients with an atypical fracture was on average nine years less than that for the hip fracture patients (72 as against 81 years, p = 0...
August 2016: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/27670281/bone-turnover-markers-and-the-factors-associated-with-atypical-femur-fractures-among-japanese-patients
#13
Yoichi Iizuka, Haku Iizuka, Tetsuya Kaneko, Tokue Mieda, Rumi Takechi, Hideki Suzuki, Yasunori Sorimachi, Takahito Suto, Masahiro Tachibana, Tomotaka Yoneyama, Takuya Omodaka, Shogo Hashimoto, Noritaka Hamano, Hideo Sakane, Daisuke Shimoyama, Isaku Kohama, Atsufumi Ohshima, Tatsuya Nozaki, Masataka Kamiyama, Tomohiko Moteki, Asuka Ohshima, Shuhei Takamine, Akira Honda, Akira Ueno, Tsuyoshi Tajika, Koichi Okamura, Toshiro Warita, Yukio Yonemoto, Hitoshi Shitara, Takashi Ohsawa, Kenji Takagishi
Many previous reports have indicated that atypical femur fractures (AFFs) are associated with the administration of bisphosphonates (BPs). A number of risk factors and hypotheses regarding the pathogenesis of AFFs have been reported to date. The purpose of the present study was to identify the factors associated with AFFs in Japanese individuals and to elucidate the association between bone metabolism and AFFs by evaluating bone turnover markers (BTMs). We prospectively reviewed all patients with femur fractures and identified the patients with AFFs and typical femur fractures (TFFs)...
September 20, 2016: Injury
https://www.readbyqxmd.com/read/27662240/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-clinical-practice-guidelines-for-the-diagnosis-and-treatment-of-postmenopausal-osteoporosis-2016
#14
Pauline M Camacho, Steven M Petak, Neil Binkley, Bart L Clarke, Steven T Harris, Daniel L Hurley, Michael Kleerekoper, E Michael Lewiecki, Paul D Miller, Harmeet S Narula, Rachel Pessah-Pollack, Vin Tangpricha, Sunil J Wimalawansa, Nelson B Watts
AACE = American Association of Clinical Endocrinologists AFF = atypical femur fracture ASBMR = American Society for Bone and Mineral Research BEL = best evidence level BMD = bone mineral density BTM = bone turnover marker CBC = complete blood count CI = confidence interval DXA = dual-energy X-ray absorptiometry EL = evidence level FDA = U.S. Food and Drug Administration FLEX = Fracture Intervention Trial (FIT) Long-term Extension FRAX(®) = Fracture Risk Assessment Tool GFR = glomerular filtration rate GI = gastrointestinal HORIZON = Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly IOF = International Osteoporosis Foundation ISCD = International Society for Clinical Densitometry IU = international units IV = intravenous LSC = least significant change NBHA = National Bone Health Alliance NOF = National Osteoporosis Foundation 25(OH)D = 25-hydroxy vitamin D ONJ = osteonecrosis of the jaw PINP = serum carboxy-terminal propeptide of type I collagen PTH = parathyroid hormone R = recommendation RANK = receptor activator of nuclear factor kappa-B RANKL = receptor activator of nuclear factor kappa-B ligand RCT = randomized controlled trial RR = relative risk S-CTX = serum C-terminal telopeptide SQ = subcutaneous VFA = vertebral fracture assessment WHO = World Health Organization...
September 2, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27643923/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-clinical-practice-guidelines-for-the-diagnosis-and-treatment-of-postmenopausal-osteoporosis-2016-executive-summary
#15
Pauline M Camacho, Steven M Petak, Neil Binkley, Bart L Clarke, Steven T Harris, Daniel L Hurley, Michael Kleerekoper, E Michael Lewiecki, Paul D Miller, Harmeet S Narula, Rachel Pessah-Pollack, Vin Tangpricha, Sunil J Wimalawansa, Nelson B Watts
AACE = American Association of Clinical Endocrinologists AFF = atypical femur fracture ASBMR = American Society for Bone and Mineral Research BEL = best evidence level BMD = bone mineral density BTM = bone turnover marker CBC = complete blood count CI = confidence interval DXA = dual-energy X-ray absorptiometry EL = evidence level FDA = U.S. Food and Drug Administration FLEX = Fracture Intervention Trial (FIT) Long-term Extension FRAX(®) = Fracture Risk Assessment Tool GFR = glomerular filtration rate GI = gastrointestinal HORIZON = Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly IOF = International Osteoporosis Foundation ISCD = International Society for Clinical Densitometry IU = international units IV = intravenous LSC = least significant change NBHA = National Bone Health Alliance NOF = National Osteoporosis Foundation 25(OH)D = 25-hydroxy vitamin D ONJ = osteonecrosis of the jaw PINP = serum carboxy-terminal propeptide of type I collagen PTH = parathyroid hormone R = recommendation RANK = receptor activator of nuclear factor kappa-B RANKL = receptor activator of nuclear factor kappa-B ligand RCT = randomized controlled trial RR = relative risk S-CTX = serum C-terminal telopeptide SQ = subcutaneous VFA = vertebral fracture assessment WHO = World Health Organization...
September 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27598911/-risk-of-atypical-femur-fractures-does-not-increase-among-alen-dronate-users
#16
Reiner Bartl
No abstract text is available yet for this article.
September 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27536624/periprosthetic-atypical-femoral-fracture-like-fracture-after-hip-arthroplasty-a-report-of-three-cases
#17
Kyung-Jae Lee, Byung-Woo Min, Hyung-Kyu Jang, Hee-Uk Ye, Kyung-Hwan Lim
Atypical femoral fractures are stress or insufficient fractures induced by low energy trauma or no trauma and have specific X-ray findings. Although the American Society for Bone and Mineral Research has excluded periprosthetic fractures from the definition of an atypical femoral fracture in 2013, this is still a matter of controversy because some authors report periprosthetic fractures showing specific features of atypical fractures around a well-fixed femoral stem. We report 3 cases of periprosthetic femur fractures that had specific radiographic features of atypical femoral fractures in patients with a history of prolonged bisphosphonate use; we also review relevant literature...
September 2015: Hip & Pelvis
https://www.readbyqxmd.com/read/27507156/hypophosphatasia-and-the-risk-of-atypical-femur-fractures-a-case-control-study
#18
Timothy Bhattacharyya, Smita Jha, Hongying Wang, Daniel L Kastner, Elaine F Remmers
BACKGROUND: Case reports have linked adult hypophosphatasia as a possible cause of atypical femur fractures (AFF) associated with bisphosphonate use. Adult hypophosphatasia is an asymptomatic genetic condition which results in low alkaline phosphatase and elevated pyridoxal phosphate. We conducted a case-control study to assess the role of hypophosphatasia and atypical femur fracture. METHODS: We recruited 13 control patients who took long term bisphosphonates without complication and 10 patients who sustained atypical femur fractures (mean bisphosphonate use, 9 years both cohorts)...
August 9, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27491286/influence-of-bisphosphonate-therapy-on-bone-geometry-volumetric-bone-density-and-bone-strength-of-femoral-shaft-in-postmenopausal-women-with-rheumatoid-arthritis
#19
Rahel Meinen, Inna Galli-Lysak, Peter M Villiger, Daniel Aeberli
BACKGROUND: There is evidence that postmenopausal women with rheumatoid arthritis (RA) on glucocorticoid (GC) therapy and bisphosphonate (BP) have an increased risk for atypical subtrochanteric and atypical diaphyseal femoral fracture (AFF). The underlying mechanism has not been elucidated so far. Using peripheral quantitative computed tomography (pQCT), the aim of the present study was to compare bone geometry, volumetric bone mineral density (vBMD) and bone strength of femoral shaft in BP-treated and BP-naïve postmenopausal women with RA...
August 5, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27477003/atypical-femur-fracture-in-an-adolescent-boy-treated-with-bisphosphonates-for-x-linked-osteoporosis-based-on-pls3-mutation
#20
Denise M van de Laarschot, M Carola Zillikens
Long-term use of bisphosphonates has raised concerns about the association with Atypical Femur Fractures (AFFs) that have been reported mainly in postmenopausal women. We report a case of an 18-year-old patient with juvenile osteoporosis based on X-linked osteoporosis due to a PLS3 mutation who developed a low trauma femoral fracture after seven years of intravenous and two years of oral bisphosphonate use, fulfilling the revised ASBMR diagnostic criteria of an AFF. The occurrence of AFFs has not been described previously in children or adolescents...
October 2016: Bone
keyword
keyword
44775
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"