keyword
MENU ▼
Read by QxMD icon Read
search

beige fat

keyword
https://www.readbyqxmd.com/read/28507012/dietary-factors-promoting-brown-and-beige-fat-development-and-thermogenesis
#1
REVIEW
Meshail Okla, Jiyoung Kim, Karsten Koehler, Soonkyu Chung
Brown adipose tissue (BAT) is a specialized fat tissue that has a high capacity to dissociate cellular respiration from ATP utilization, resulting in the release of stored energy as heat. Adult humans possess a substantial amount of BAT in the form of constitutively active brown fat or inducible beige fat. BAT activity in humans is inversely correlated with adiposity, blood glucose concentrations, and insulin sensitivity; this suggests that strategies aimed at BAT-mediated bioenergetics are an attractive therapeutic target in combating the continuing epidemic of obesity and diabetes...
May 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28467890/brown-and-brite-adipocytes-same-function-but-different-origin-and-response
#2
REVIEW
Dinh-Toi Chu, Barbara Gawronska-Kozak
Inducing brown adipocytes in white adipose tissues is a promising target to combat obesity and its related disorders in human beings. This goal has been especially encouraged by new important discoveries of human brown adipose tissues. The accumulating evidence confirms the presence of active brown adipocytes, not only in newborns, but also in adult humans. In rodents, there are two populations of the Ucp1-expressing adipocytes with well characterized-thermogenic functions, classical interscapular brown adipocytes and brite/beige adipocytes (brown adipocytes that are induced in white adipose tissues)...
April 30, 2017: Biochimie
https://www.readbyqxmd.com/read/28465400/the-significance-of-beige-and-brown-fat-in-humans
#3
Florian W Kiefer
Promotion of brown adipose tissue (BAT) activity or browning of white adipose tissue has shown great potential as anti-obesity strategy in numerous preclinical models. The discovery of active BAT in humans and the recent advances in the understanding of human BAT biology and function have significantly propelled this field of research. Pharmacological stimulation of energy expenditure to counteract obesity has always been an intriguing therapeutic concept; with the identification of the specific molecular pathways of brown fat function this idea has now become as realistic as ever...
May 2, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28464448/gene-expression-changes-of-thermo-sensitive-transient-receptor-potential-channels-in-obese-mice
#4
Wuping Sun, Chen Lib, Yonghong Zhang, Changyu Jiang, Mingzhu Zhai, Qian Zhou, Lizu Xiao, Qiwen Deng
Adipose tissues play key roles in energy homeostasis. Brown adipocytes and beige adipocytes in white adipose tissue (WAT) sharethe similar characters of thermogenesis, both of them could be potential targets for obesity management. Several thermo-sensitive transient receptor potential channels (thermoTRPs) are shown to be involved in adipocyte biology. However, the expression pattern of thermoTRPs in adipose tissues from obese mice is still unknown. The mRNA expression of thermoTRPs in subcutaneous WAT (sWAT) and interscapular brown adipose tissue (iBAT) from lean and obese mice were measured using Reverse Transcriptase-quantitative PCRs (RT-qPCR)...
May 2, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28461471/lsd1-prevents-age-programed-loss-of-beige-adipocytes
#5
Delphine Duteil, Milica Tosic, Dominica Willmann, Anastasia Georgiadi, Toufike Kanouni, Roland Schüle
Aging is accompanied by major changes in adipose tissue distribution and function. In particular, with time, thermogenic-competent beige adipocytes progressively gain a white adipocyte morphology. However, the mechanisms controlling the age-related transition of beige adipocytes to white adipocytes remain unclear. Lysine-specific demethylase 1 (Lsd1) is an epigenetic eraser enzyme positively regulating differentiation and function of adipocytes. Here we show that Lsd1 levels decrease in aging inguinal white adipose tissue concomitantly with beige fat cell decline...
May 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28448947/traveling-from-the-hypothalamus-to-the-adipose-tissue-the-thermogenic-pathway
#6
REVIEW
Cristina Contreras, Rubén Nogueiras, Carlos Diéguez, Kamal Rahmouni, Miguel López
Brown adipose tissue (BAT) is a specialized tissue critical for non-shivering thermogenesis producing heat through mitochondrial uncoupling; whereas white adipose tissue (WAT) is responsible of energy storage in the form of triglycerides. Another type of fat has been described, the beige adipose tissue; this tissue emerges in existing WAT depots but with thermogenic ability, a phenomenon known as browning. Several peripheral signals relaying information about energy status act in the brain, particularly the hypothalamus, to regulate thermogenesis in BAT and browning of WAT...
April 15, 2017: Redox Biology
https://www.readbyqxmd.com/read/28431377/metabolic-regulation-and-the-anti-obesity-perspectives-of-human-brown-fat
#7
REVIEW
Camilla Scheele, Søren Nielsen
Activation of brown adipose tissue (BAT) in adult humans increase glucose and fatty acid clearance as well as resting metabolic rate, whereas a prolonged elevation of BAT activity improves insulin sensitivity. However, substantial reductions in body weight following BAT activation has not yet been shown in humans. This observation raise the possibility for feedback mechanisms in adult humans in terms of a brown fat-brain crosstalk, possibly mediated by batokines, factors produced by and secreted from brown fat...
April 11, 2017: Redox Biology
https://www.readbyqxmd.com/read/28380374/mitochondrial-patch-clamp-of-beige-adipocytes-reveals-ucp1-positive-and-ucp1-negative-cells-both-exhibiting-futile-creatine-cycling
#8
Ambre M Bertholet, Lawrence Kazak, Edward T Chouchani, Marta G Bogaczyńska, Ishan Paranjpe, Gabrielle L Wainwright, Alexandre Bétourné, Shingo Kajimura, Bruce M Spiegelman, Yuriy Kirichok
Cold and other environmental factors induce "browning" of white fat depots-development of beige adipocytes with morphological and functional resemblance to brown fat. Similar to brown fat, beige adipocytes are assumed to express mitochondrial uncoupling protein 1 (UCP1) and are thermogenic due to the UCP1-mediated H(+) leak across the inner mitochondrial membrane. However, this assumption has never been tested directly. Herein we patch clamped the inner mitochondrial membrane of beige and brown fat to provide a direct comparison of their thermogenic H(+) leak (IH)...
April 4, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28370281/new-insights-into-the-local-and-systemic-functions-of-sclerostin-regulation-of-quiescent-bone-lining-cells-and-beige-adipogenesis-in-peripheral-fat-depots
#9
Jesus Delgado-Calle, Teresita Bellido
No abstract text is available yet for this article.
May 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28355132/angiopoietin-2-in-white-adipose-tissue-improves-metabolic-homeostasis-through-enhanced-angiogenesis
#10
Yu A An, Kai Sun, Nolwenn Joffin, Fang Zhang, Yingfeng Deng, Olivier Donzé, Christine M Kusminski, Philipp E Scherer
Despite many angiogenic factors playing crucial roles in metabolic homeostasis, effects of angiopoietin-2 (ANG-2) in adipose tissue (AT) remain unclear. Utilizing a doxycycline-inducible AT-specific ANG-2 overexpression mouse model, we assessed the effects of ANG-2 in AT expansion upon a high-fat diet (HFD) challenge. ANG-2 is significantly induced, with subcutaneous white AT (sWAT) displaying the highest ANG-2 expression. ANG-2 overexpressing mice show increased sWAT vascularization and are resistant to HFD-induced obesity...
March 29, 2017: ELife
https://www.readbyqxmd.com/read/28338809/resveratrol-derivative-btm-0512-mitigates-obesity-by-promoting-beige-remodeling-of-subcutaneous-preadipocytes
#11
Qingqing Li, Kuansong Wang, Yipeng Ma, Chunxiang Qin, Changsheng Dong, Ping Jin, Yan Wu, Xiaoming Xiong, Niansheng Li, Changping Hu, Jun Peng, Zhichun Yang
Recent studies revealed that sirtuin 1 (SIRT1) is involved in the regulation of energy metabolism and its agonist resveratrol showed anti-obesity effect. This study aims to determine whether BTM-0512, a novel derivative of resveratrol, acts as an antagonist of obesity and to explore its possible mechanisms. High-fat diet (HFD)-induced obese mice were intragastrically administered with BTM-0512 (5, 10, and 20 mg/kg/day) or resveratrol (10 mg/kg/day). It was found that the body weight, Lee's index, ratio of visceral adipose tissue (VAT) to body weight, and blood glucose were significantly reduced in BTM-0512-treated mice when compared with those in mice treated with resveratrol...
February 24, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28302705/brown-and-beige-adipose-tissues-phenotype-and-metabolic-potential-in-mice-and-men
#12
Kanta Chechi, Wouter David van Marken Lichtenbelt, Denis Richard
With the recent re-discovery of brown fat in adult humans, our outlook on adipose tissue biology has undergone a paradigm shift. While we attempt to identify, recruit and activate classic brown fat stores in humans, identification of beige/brite adipocytes has also raised the possibility of browning our white fat stores. Whether such transformation of human white fat depots can be achieved in order to enhance the whole-body oxidative potential remains to be seen. Evidence to-date, however, largely points towards a major oxidative role only for classic brown fat depots in rodents and in humans (e...
March 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28301844/the-placenta-maternal-diet-and-adipose-tissue-development-in-the-newborn
#13
Michael E Symonds, Ian Bloor, Shalini Ojha, Helen Budge
BACKGROUND: A majority of adipose tissue present in the newborn possess the unique mitochondrial protein, uncoupling protein (UCP1). It is thus highly metabolically active and capable of producing 300 times more heat per unit mass than any other organ in the body. The extent to which maternal obesity and/or an obesogenic diet impacts on placental function thereby resetting the relative distribution of different types of fat in the fetus is unknown. SUMMARY: Developmentally the majority (if not all) fat in the fetus can be considered as classical brown fat, in which UCP1 is highly abundant...
March 17, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28270523/id1-promotes-obesity-by-suppressing-brown-adipose-thermogenesis-and-white-adipose-browning
#14
Mallikarjun Patil, Bal Krishan Sharma, Sawsan Elattar, Judith Chang, Shweta Kapil, Jinling Yuan, Ande Satyanarayana
Obesity results from increased energy intake or defects in energy expenditure. Brown adipose tissue (BAT) is specialized for energy expenditure, a process called adaptive thermogenesis. Peroxisome proliferator activated receptor γ coactivator 1α (PGC1α) controls BAT-mediated thermogenesis by regulating the expression of Ucp1 Inhibitor of differentiation 1 (Id1) is a helix-loop-helix transcription factor that plays important roles in cell proliferation and differentiation. Here, we demonstrate a novel function of Id1 in BAT thermogenesis and programming of beige adipocytes in white adipose tissue (WAT)...
March 7, 2017: Diabetes
https://www.readbyqxmd.com/read/28257939/cold-exposure-induces-the-acquisition-of-brown-adipocyte-gene-expression-profiles-in-cattle-inguinal-fat-normalized-with-a-new-set-of-reference-genes-for-qrt-pcr
#15
K X Cao, D Hao, J Wang, W W Peng, Y J Yan, H X Cao, F Sun, H Chen
The last few years have seen great advances in our understanding of browning in white adipose tissue (WAT) where white adipocytes take on characteristics of brown adipocytes. At present, the economic significance of browning for animal husbandry is beginning to be realized with the emerging evidence that browning affects body weight not only in human and rodent but in farm animals. Quantitative RT-PCR provides a quick and sensitive way to preliminary determine browning of WAT. However, there have been no established condition specific reference genes for browning of cattle WAT...
February 24, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28254844/vegf-a-expressing-adipose-tissue-shows-rapid-beiging-enhanced-survival-after-transplantation-and-confers-il4-independent-metabolic-improvements
#16
Jiyoung Park, Min Kim, Kai Sun, Yu Aaron An, Xue Gu, Philipp E Scherer
Adipocyte-derived VEGF-A plays a crucial role in angiogenesis and contributes to adipocyte function and systemic metabolism, such as insulin resistance, chronic inflammation and beigeing of subcutaneous adipose tissue. Utilizing a doxycycline (Dox)-inducible adipocyte-specific VEGF-A overexpressing mouse model, we investigated the dynamics of local VEGF-A effects on tissue beiging of adipose tissue transplants. VEGF-A overexpression in adipocytes triggers angiogenesis. We also observe a rapid appearance of beige fat cells in subcutaneous white adipose tissue (sWATs) within as early as 2 days post induction of VEGF-A...
March 2, 2017: Diabetes
https://www.readbyqxmd.com/read/28244044/genetic-mouse-models-the-powerful-tools-to-study-fat-tissues
#17
Xingxing Kong, Kevin W Williams, Tiemin Liu
Obesity and Type 2 diabetes (T2D) are associated with a variety of comorbidities that contribute to mortality around the world. Although significant effort has been expended in understanding mechanisms that mitigate the consequences of this epidemic, the field has experienced limited success thus far. The potential ability of brown adipose tissue (BAT) to counteract obesity and metabolic disease in rodents (and potentially in humans) has been a topical realization. Recently, there is also another thermogenic fat cell called beige adipocytes, which are located among white adipocytes and share similar activated responses to cyclic AMP as classical BAT...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28244038/flow-cytometric-isolation-and-differentiation-of-adipogenic-progenitor-cells-into-brown-and-brite-beige-adipocytes
#18
Jochen Steinbring, Antonia Graja, Anne-Marie Jank, Tim J Schulz
Aside from mature adipocytes, adipose tissue harbors several distinct cell populations including immune cells, endothelial cells, and adipogenic progenitor cells (AdPCs). AdPCs represent the reservoir of regenerative cells that replenishes adipocytes during normal cellular turnover and during times of increased demand for triglyceride-storage capacity. The worldwide increase in pathologies associated with the metabolic syndrome, such as obesity and type-2 diabetes, has heightened public and scientific interest in adipose tissues and the cell biological processes of adipose tissue formation and function...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28244037/flow-cytometry-assisted-isolation-of-adipose-tissue-derived-stem-cells
#19
Umesh D Wankhade, Sushil G Rane
Adipose tissue dysfunction is typically seen in metabolic diseases, particularly obesity and diabetes. White adipocytes store fat while brown adipocyte dissipates it via thermogenesis. In addition, beige adipocytes develop in white fat depots in response to stimulation of β-adrenergic pathways. It appears that the three types of adipocytes-white, brown, and beige-can be formed de novo from stem/precursor cells or via transdifferentiation. Identifying the presumptive progenitors that harbor capacity to differentiate to these distinct adipocyte cell types will enable their functional characterization...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28242620/rheb-inhibits-beigeing-of-white-adipose-tissue-via-pde4d5-dependent-down-regulation-of-the-camp-pka-signaling-pathway
#20
Wen Meng, Xiuci Liang, Hongzhi Chen, Hairong Luo, Juli Bai, Guangdi Li, Qinghai Zhang, Ting Xiao, Sijia He, Yacheng Zhang, Zhipeng Xu, Bo Xiao, Meilian Liu, Fang Hu, Feng Liu
Beigeing of white adipose tissue has potential anti-obesity and anti-diabetes effects, yet the underlying signaling mechanisms remain to be fully elucidated. Here we show that adipose-specific knockout of Rheb, an upstream activator of mTORC1, protects mice from high fat diet-induced obesity and insulin resistance. Rheb deficiency in adipose tissue reduced mTORC1 signaling, increased lipolysis, and promoted beigeing and energy expenditure. On the other hand, overexpression of Rheb in primary adipocytes significantly inhibited CREB phosphorylation and UCP1 expression...
February 27, 2017: Diabetes
keyword
keyword
44774
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"