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intermittent hypoxia

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https://www.readbyqxmd.com/read/28936176/chronic-intermittent-hypoxia-differentially-impacts-different-states-of-inspiratory-activity-at-the-level-of-the-preb%C3%A3-tzinger-complex
#1
Alfredo J Garcia, Tatiana Dashevskiy, Maggie A Khuu, Jan-Marino Ramirez
The preBötzinger complex (preBötC) is a medullary brainstem network crucially involved in the generation of different inspiratory rhythms. In the isolated brainstem slice, the preBötC reconfigures to produce different rhythms that we refer to as "fictive eupnea" under baseline conditions (i.e., carbogen), and "fictive gasping" in hypoxia. We recently demonstrated that fictive eupnea is irregular following exposure to chronic intermittent hypoxia (CIH). However, it is unknown how CIH impacts fictive gasping...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28934520/damage-of-inner-ear-sensory-hair-cells-via-mitochondrial-loss-in-a-murine-model-of-sleep-apnea-with-chronic-intermittent-hypoxia
#2
Young Joon Seo, Hyun Mi Ju, Sun Hee Lee, Sang Hyun Kwak, Min Jung Kang, Joo-Heon Yoon, Chang-Hoon Kim, Hyung-Ju Cho
Study Objectives: Investigating the exact pathophysiology of obstructive sleep apnea syndrome (OSAS)-induced hearing loss is critical. We sought to verify the hypothesis that a correlation exists between mitochondrial dysfunction in inner ear hair cells and the auditory dysfunction induced by chronic intermittent hypoxia (CIH) in a murine model of sleep apnea. Methods: C57BL/6J adult male mice were randomized to 4 weeks of CIH (n = 12) or normoxia (Sham) (n = 12)...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28926865/effects-of-hypoxia-during-continuous-and-intermittent-exercise-on-glycaemic-control-and-selected-markers-of-vascular-function-in-type-1-diabetes
#3
Barbara Hall, Aleksandra Zebrowska, Tomasz Kaminski, Arkadiusz Stanula, Anna Robins
Objectives The aim of the study was to assess the effect of continuous and intermittent exercise in hypoxia on glycaemic control and selected markers of vascular function in patients with Type 1 diabetes (T1D). Methods 12 patients suffering from T1D for 12.1±6.0 years and 12 healthy adults performed: continuous exercise (ExC) and intermittent exercise (ExInt) in normoxia and hypoxia (FiO₂=15.1%). Glycaemia and proangiogenic factors concentrations were measured at rest and immediately after exercise. Results T1D patients' glycaemia decreased in response to ExC (p<0...
September 19, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28926567/critical-developmental-windows-for-morphology-and-hematology-revealed-by-intermittent-and-continuous-hypoxic-incubation-in-embryos-of-quail-coturnix-coturnix
#4
Warren W Burggren, Nourhan A Elmonoufy
Hypoxia during embryonic growth in embryos is frequently a powerful determinant of development, but at least in avian embryos the effects appear to show considerable intra- and inter-specific variation. We hypothesized that some of this variation may arise from different protocols that may or may not result in exposure during the embryo's critical window for hypoxic effects. To test this hypothesis, quail embryos (Coturnix coturnix) in the intact egg were exposed to hypoxia (~15% O2) during "early" (Day 0 through Day 5, abbreviated as D0-D5), "middle" (D6-D10) or "late" (D11-D15) incubation or for their entire 16-18 day incubation ("continuous hypoxia") to determine critical windows for viability and growth...
2017: PloS One
https://www.readbyqxmd.com/read/28923778/links-between-lower-urinary-tract-symptoms-intermittent-hypoxia-and-diabetes-causes-or-cures
#5
REVIEW
Lisa L Abler, Chad M Vezina
Bothersome lower urinary tract symptoms (LUTS) manifest as urinary frequency, urgency, incontinence and incomplete bladder emptying. Existing treatments ameliorate but do not eliminate most symptoms, leading to financial and personal burdens attributable to sustained medical therapies that may last a lifetime. The purpose of this review is to highlight evidence of causal associations between LUTS and several common comorbidities, including intermittent hypoxia (IH) concomitant with obstructive sleep apnea (OSA), obesity, metabolic syndrome and type 2 diabetes...
September 15, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28923362/human-retinal-endothelial-cells-and-astrocytes-cultured-on-3-d-scaffolds-for-ocular-drug-discovery-and-development
#6
Kay D Beharry, Charles L Cai, Gloria B Valencia, Douglas Lazzaro, Arwin M Valencia, Fabrizio Salomone, Jacob V Aranda
Topical ocular ketorolac improves the outcomes of severe retinopathy of prematurity and when administered with systemic caffeine, decreases the severity of oxygen-induced retinopathy. We tested the hypothesis that co-cultures of human retinal endothelial cells (HRECs) and human retinal astrocytes (HRAs) on 3-dimensional (3-D) hydrogel scaffolds is a more representative biomimetic paradigm of the blood-retinal-barrier (BRB) than 2-D cultures, and should be utilized for preclinical drug discovery and development...
September 15, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28922718/tanshinone-iia-protects-against-chronic-intermittent-hypoxia-induced-myocardial-injury-via-activating-the-endothelin-1-pathway
#7
Na Wang, Yue Chang, Lingling Chen, Ya-Jing Guo, Ya-Shuo Zhao, Qiu-Hong Guo, En-Sheng Ji
Tanshinone IIA (Tan IIA) may exert significant protective effects against heart oxidative stress damage in obstructive sleep apnoea (OSA) syndrome. Chronic intermittent hypoxia (CIH)-triggered left ventricular dysfunction is used in a rat model to mimic CIH in OSA patients. 48 rats were randomly divided into three groups: normal control (NC) group, CIH group and CIH+Tan IIA group with 16 rats in each group. At the end of experiment (day 21), the blood pressure, Plasma ET-1 and NO content, hemodynamic indexes, heart histology, myocardial apoptosis as well as the expression of eNOS, ET-1, ETA receptor and ETB receptor were compared among different groups...
September 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28920806/accuracy-of-noninvasive-anesthetic-monitoring-in-the-anesthetized-giraffe-giraffa-camelopardalis
#8
Mads F Bertelsen, Carsten Grøndahl, George F Stegmann, Cathrine Sauer, Niels H Secher, J Michael Hasenkam, Mads Damkjær, Christian Aalkjær, Tobias Wang
This study evaluated the accuracy of pulse oximetry, capnography, and oscillometric blood pressure during general anesthesia in giraffes (Giraffa camelopardalis). Thirty-two giraffes anesthetized for physiologic experiments were instrumented with a pulse oximeter transmittance probe positioned on the tongue and a capnograph sampling line placed at the oral end of the endotracheal tube. A human size 10 blood pressure cuff was placed around the base of the tail, and an indwelling arterial catheter in the auricular artery continuously measured blood pressure...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28901388/inhibitory-effects-of-17%C3%AE-estradiol-or-a-resveratrol-dimer-on-hypoxia-inducible-factor-1%C3%AE-in-genioglossus-myoblasts-involvement-of-er%C3%AE-and-its-downstream-p38%C3%A2-mapk-pathways
#9
Yuanyuan Li, Yuehua Liu, Yun Lu, Bingjiao Zhao
Deficiency in the functioning of the genioglossus, which is one of the upper airway dilator muscles, is an important cause of obstructive sleep apnea/hypopnea syndrome (OSAHS). Estrogens have been reported to inhibit hypoxia-inducible factor-1α (HIF-1α) expression in hypoxia, regulating its target genes and exerting protective effects on the genioglossus in chronic intermittent hypoxia (CIH). This study aimed to investigate the role of 17β-estradiol (E2) and a resveratrol dimer (RD) on HIF-1α and the underlying mechanism...
September 7, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28894286/intermittent-hypoxia-induced-insulin-resistance-is-associated-with-alterations-in-white-fat-distribution
#10
Laureline Poulain, Hervé Mathieu, Amandine Thomas, Anne-Laure Borel, Chantal Remy, Patrick Levy, Claire Arnaud, Maurice Dematteis
Sleep apnea syndrome is characterized by repetitive upper airway collapses during night leading to intermittent hypoxia (IH). The latter is responsible for metabolic disturbances that rely, at least in part, on abdominal white fat inflammation. Besides qualitative alterations, we hypothesized that IH could also modify body fat distribution, a key factor for metabolic complications. C57BL6 mice exposed to IH (21-5% FiO2, 60 s cycle, 8 h/day) or air for 6 weeks were investigated for topographic fat alterations (whole-body MRI)...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893651/obstructive-sleep-apnea-is-associated-with-altered-midbrain-chemical-concentrations
#11
Paul M Macey, Manoj K Sarma, Janani P Prasad, Jennifer A Ogren, Ravi Aysola, Ronald M Harper, M Albert Thomas
Obstructive sleep apnea (OSA) is accompanied by altered structure and function in cortical, limbic, brainstem, and cerebellar regions. The midbrain is relatively unexamined, but contains many integrative nuclei which mediate physiological functions that are disrupted in OSA. We therefore assessed the chemistry of the midbrain in OSA in this exploratory study. We used a recently-developed accelerated 2D magnetic resonance spectroscopy (2D-MRS) technique, compressed sensing-based 4D echo-planar J-resolved spectroscopic imaging (4D-EP-JRESI), to measure metabolites in the midbrain of 14 OSA (mean age±SD:54...
September 8, 2017: Neuroscience
https://www.readbyqxmd.com/read/28893610/sex-differences-in-the-respiratory-sympathetic-coupling-in-rats-exposed-to-chronic-intermittent-hypoxia
#12
REVIEW
George Miguel P R Souza, Mateus R Amorim, Davi J A Moraes, Benedito H Machado
Obstructive sleep apnea (OSA) is a complex disease in which humans face episodes of intermittent hypoxia and it affects men and women. Patients with OSA present hypertension and sympathetic overactivity among several other dysfunctions. Therefore, one important question remains: are the autonomic dysfunctions associated with OSA similar in male and female? This is an unresolved question since sex factors are overlooked in most clinical and experimental studies. Epidemiological data indicate that sex exerts an important influence in the prevalence of OSA and associated comorbidities, such as hypertension...
September 8, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28882901/chronic-intermittent-hypoxia-impairs-insulin-sensitivity-but-improves-whole-body-glucose-tolerance-by-activating-skeletal-muscle-ampk
#13
Amandine Thomas, Elise Belaidi, Sophie Moulin, Sandrine Horman, Gerard C van der Zon, Benoit Viollet, Patrick Levy, Luc Bertrand, Jean-Louis Pepin, Diane Godin-Ribuot, Bruno Guigas
Obstructive sleep apnea syndrome is a highly prevalent disease resulting in transient respiratory arrest and chronic intermittent hypoxia (cIH). cIH is associated with insulin resistance and impaired metabolic homeostasis in both rodents and humans but the exact underlying mechanism(s) remains unclear. In the present study, we investigated the effects of two weeks of cIH (1min cycle, FiO2 21-5%, 8h/day) on whole-body insulin sensitivity and glucose tolerance in lean mice. Although food intake and body weight were reduced when compared to normoxia, cIH induced systemic insulin resistance in a hypoxia-inducible factor-1α-independent manner and impaired insulin signaling in liver, white adipose tissue and skeletal muscle...
September 7, 2017: Diabetes
https://www.readbyqxmd.com/read/28878129/correction-of-intermittent-hypoxia-reduces-inflammation-in-obese-subjects-with-obstructive-sleep-apnea
#14
Sebastio Perrini, Angelo Cignarelli, Vitaliano Nicola Quaranta, Vito Antonio Falcone, Stella Kounaki, Stefania Porro, Alessandro Ciavarella, Romina Ficarella, Maria Barbaro, Valentina Annamaria Genchi, Pasquale Nigro, Pierluigi Carratù, Annalisa Natalicchio, Luigi Laviola, Onofrio Resta, Francesco Giorgino
BACKGROUND: In obese subjects with obstructive sleep apnea (OSA), chronic intermittent hypoxia (CIH) may be linked to systemic and adipose tissue inflammation. METHODS: We obtained abdominal subcutaneous adipose tissue biopsies from OSA and non-OSA obese (BMI > 35) subjects at baseline and after 24 weeks (T1) of weight-loss intervention plus continuous positive airway pressure (c-PAP) or weight-loss intervention alone, respectively. OSA subjects were grouped according to good (therapeutic) or poor (subtherapeutic) adherence to c-PAP...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28871193/estradiol-regulates-txnip-and-prevents-intermittent-hypoxia-induced-vascular-injury
#15
Xiao Fei Lan, Xiu Juan Zhang, Ying Ni Lin, Qiong Wang, Hua Jun Xu, Li Na Zhou, Pei Li Chen, Qing Yun Li
Chronic intermittent hypoxia (IH) contributes to obstructive sleep apnea (OSA)-related cardiovascular diseases through increasing oxidative stress. It has been widely recognized that estradiol decreases the risk for cardiovascular disease, but the estrogen replacement therapy is limited for its side effects. Thioredoxin (Trx) and its endogenous inhibitor, thioredoxin-interacting protein (Txnip), are associated with the protective effect of estradiol in some conditions. In this study, we aimed to explore whether estradiol could protect against IH-induced vascular injury, and the possible effect of Trx-1/Txnip in this process...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28857989/albuminuria-in-pediatric-patients-with-adenotonsillar-hypertrophy
#16
Ozlem Unsal, Gulpembe Bozkurt, Meltem Esen Akpinar, Egehan Salepci, Gokce Aktas Oguz, Berna Uslu Coskun
The relationship between intermittent nocturnal hypoxia and albuminuria in pediatric patients with adenotonsillar hypertrophy was evaluated in this prospective study. Fifty children with grade 3 to 4 adenotonsillar hypertrophy scheduled for adenoidectomy and/or adenotonsillectomy were selected for study group. Fifteen patients with adenotonsillar grade 1 to 2 or adenotonsillectomized subjects in a similar range of sex, age, and body mass index scheduled for other surgeries were selected for control group. All children were monitored using finger pulse oximeter during the night before surgery...
August 28, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28853429/obstructive-sleep-apnea-osa-and-driving-safety
#17
Sergio Garbarino
Intermittent hypoxia and sleep fragmentation cause excessive daytime sleepiness (EDS) and cognitive impairment in obstructive sleep apnoea (OSA); neuroimaging and neurophysiological studies in patients with OSA have delineated a putative regional "fingerprint" of OSA-induced brain injury: a disconnection of the fronto-parietal regions and a disruption of the thalamocortical oscillator, with involvement of the hippocampal formation with impaired attention, awareness, working memory, time reaction, visuoconstructive and executive functions...
August 28, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28846046/the-use-of-simulated-altitude-techniques-for-beneficial-cardiovascular-health-outcomes-in-nonathletic-sedentary-and-clinical-populations-a-literature-review
#18
Catherine A Lizamore, Michael J Hamlin
Lizamore, Catherine A., and Michael J. Hamlin. The use of simulated altitude techniques for beneficial cardiovascular health outcomes in nonathletic, sedentary, and clinical populations: A literature review. High Alt Med Biol 00:000-000, 2017. BACKGROUND: The reportedly beneficial improvements in an athlete's physical performance following altitude training may have merit for individuals struggling to meet physical activity guidelines. AIM: To review the effectiveness of simulated altitude training methodologies at improving cardiovascular health in sedentary and clinical cohorts...
August 28, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28839104/epigenetic-changes-by-dna-methylation-in-chronic-and-intermittent-hypoxia
#19
Jayasri Nanduri, Gregg L Semenza, Nanduri R Prabhakar
DNA methylation of cytosine residues is a well-studied epigenetic change, which regulates gene transcription by altering accessibility for transcription factors. Hypoxia is a pervasive stimulus that affects many physiological processes. The circulatory and respiratory systems adapt to chronic sustained hypoxia, such as that encountered during a high altitude sojourn. Many people living at sea level experience chronic intermittent hypoxia (IH) due to sleep apnea, which leads to cardiovascular and respiratory maladaptation...
August 24, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28835062/-effects-of-chronic-intermittent-hypoxia-on-left-ventricular-myocardial-contractibility-in-a-rabbit-model-of-obstructive-sleep-apnea
#20
L F Xu, Y F Cai, K Hu, S Tang, X F Zhou, H M Li
Objective: To explore the effects of chronic intermittent hypoxia (CIH) on left ventricular myocardial contractibility in a rabbit model of obstructive sleep apnea (OSA). Methods: Based on random number table, twenty-four rabbits were randomly divided into three groups: operation, sham, and control groups, each with 8 rabbits. The rabbit model for OSA in operation group was established by repeatedly closing the airway and then reopening it. Upper airway obstructions were conducted on rabbits every day, which were alternately closed for 15 s and then reopened for 75 s in a 90 s-long cycle, for 8 h each day over 3 months...
August 22, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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