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diabetes mellitus type II

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https://www.readbyqxmd.com/read/28942551/androgen-excess-and-metabolic-disorders-in-women-with-pcos-beyond-the-body-mass-index
#1
REVIEW
R A Condorelli, A E Calogero, M Di Mauro, L M Mongioi', R Cannarella, G Rosta, S La Vignera
BACKGROUND: Insulin resistance is a common feature among women with polycystic ovary syndrome (PCOS), especially in those patients with hyperandrogenism and chronic anovulation. PCOS women are at risk for developing metabolic syndrome, impaired glucose tolerance and type II diabetes mellitus (DM II). OBJECTIVE: The aim of this review is to explore the existing knowledge of the interplay between androgen excess, pancreatic β-cell function, non-alcoholic fatty liver disease (NAFLD), intra-abdominal and subcutaneous (SC) abdominal adipocytes in PCOS, providing a better comprehension of the molecular mechanisms of diabetologic interest...
September 23, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28934715/stercoral-perforation-of-the-rectosigmoid-colon-due-to-chronic-constipation-a-case-report
#2
Mustafa Fevzi Celayir, Hakan Mustafa Köksal, Mehmet Uludag
INTRODUCTION: Chronic constipation is very common in elderly patients. As a result of this situation fecaloma is also frequently seen at these ages. However, the stercoral perforation caused by fecaloma is a rare situation to occur. The rectosigmoid colon is the most affected colonic segment. It is seen in older patients with concomitant diseases and a low quality of life. PRESENTATION OF CASE: Here in this case, we have to report an 83 - year-old male patient who came to the emergency room with complaints of abdominal pain and constipation for two days...
September 14, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28932046/analysis-of-lip-print-and-fingerprint-patterns-in-patients-with-type-ii-diabetes-mellitus
#3
P Manjusha, S Sudha, P M Shameena, R Chandni, Sujatha Varma, Deepak Pandiar
BACKGROUND AND OBJECTIVES: Globally, the prevalence of diabetes is soaring high in the recent times. There is an ardent search in the scientific community for a reliable and cheap early predictor which can serve the purpose of mass screening of a genetically vulnerable population. Hence, the present study was conducted to assess the predictive role of cheiloscopy on type II diabetes mellitus (T2DM). Several studies have established the association of dermatoglyphics with diabetes. However, results are still far from satisfaction...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28927249/gut-microbiota-obesity-and-metabolic-disorders
#4
Alessandro Federico, Marcello Dallio, Rosa DI Sarno, Valentina Giorgio, Luca Miele
Obesity, diabetes and metabolic disorders represent hugely significant problems concerning the health in Western countries and the study of gut microbiota in metabolic pathologies is part of this framework. Diet effects on intestinal microbial composition and its role in pathogenetic mechanisms responsible for both obesity and systemic, hepatic and adipose tissue inflammation, represent at the moment one of this mostpromising topic in gastroenterology research. Gut health safety is essential, but it needs to be further explored in order to understand and interrupt the pathogenetic mechanisms, which support a large number of diseases...
December 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28923834/is-chronic-dialysis-the-right-hard-renal-end-point-to-evaluate-renoprotective-drug-effects
#5
Misghina Weldegiorgis, Dick de Zeeuw, Jamie P Dwyer, Peter Mol, Hiddo J L Heerspink
BACKGROUND AND OBJECTIVES: RRT and doubling of serum creatinine are considered the objective hard end points in nephrology intervention trials. Because both are assumed to reflect changes in the filtration capacity of the kidney, drug effects, if present, are attributed to kidney protection. However, decisions to start RRT are not only on the basis of filtration capacity of the kidney, but also on other factors. We therefore compared the time to RRT with the time to a fixed eGFR threshold and assessed the effect of the renoprotective drug irbesartan on both components...
September 18, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28920088/metabolic-and-transcriptomic-analysis-of-huntington-s-disease-model-reveal-changes-in-intracellular-glucose-levels-and-related-genes
#6
Gepoliano Chaves, Rıfat Emrah Özel, Namrata V Rao, Hana Hadiprodjo, Yvonne Da Costa, Zachary Tokuno, Nader Pourmand
Huntington's Disease (HD) is a neurodegenerative disorder caused by an expansion in a CAG-tri-nucleotide repeat that introduces a poly-glutamine stretch into the huntingtin protein (mHTT). Mutant huntingtin (mHTT) has been associated with several phenotypes including mood disorders and depression. Additionally, HD patients are known to be more susceptible to type II diabetes mellitus (T2DM), and HD mice model develops diabetes. However, the mechanism and pathways that link Huntington's disease and diabetes have not been well established...
August 2017: Heliyon
https://www.readbyqxmd.com/read/28915786/nutrition-in-primary-and-secondary-prevention-of-cardiovascular-risk-in-the-continental-and-mediterranean-regions-of-croatia
#7
Jozica Sikic, Mira Stipcevic, Hrvoje Vrazic, Jasna Cerkez Habek, Eduard Margetic, Dario Gulin
BACKGROUND: The aim of this observational study was to evaluate the effect of Mediterranean and continental nutrition on cardiovascular risk in patients with acute and chronic coronary heart disease in Croatia. METHODS: The study included 1284 patients who were hospitalized in a 28-month period due to acute or chronic ischaemic heart disease in hospitals across Croatia. An individual questionnaire was prepared which enabled recording of various cardiovascular risk factors...
September 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28914815/a-systematic-review-family-support-integrated-with-diabetes-self-management-among-uncontrolled-type-ii-diabetes-mellitus-patients
#8
REVIEW
Rian Adi Pamungkas, Kanittha Chamroonsawasdi, Paranee Vatanasomboon
The rate of type-2 diabetes mellitus (T2D) is dramatically increasing worldwide. Continuing diabetes mellitus (DM) care needs effective self-management education and support for both patients and family members. This study aimed to review and describe the impacts of diabetes mellitus self-management education (DSME) that involve family members on patient outcomes related to patient health behaviors and perceived self-efficacy on self-management such as medication adherence, blood glucose monitoring, diet and exercise changes, health outcomes including psychological well-being and self-efficacy, and physiological markers including body mass index, level of blood pressure, cholesterol level and glycemic control...
September 15, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28913364/the-nrf2-keap1-are-pathway-and-oxidative-stress-as-a-therapeutic-target-in-type-ii-diabetes-mellitus
#9
REVIEW
Joshua A David, William J Rifkin, Piul S Rabbani, Daniel J Ceradini
Despite improvements in awareness and treatment of type II diabetes mellitus (TIIDM), this disease remains a major source of morbidity and mortality worldwide, and prevalence continues to rise. Oxidative damage caused by free radicals has long been known to contribute to the pathogenesis and progression of TIIDM and its complications. Only recently, however, has the role of the Nrf2/Keap1/ARE master antioxidant pathway in diabetic dysfunction begun to be elucidated. There is accumulating evidence that this pathway is implicated in diabetic damage to the pancreas, heart, and skin, among other cell types and tissues...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28912879/a-crossover-study-of-the-combination-therapy-of-metformin-and-exenatide-or-biphasic-insulin-aspart-30-in-overweight-or-obese-patients-newly-diagnosed-with-type-2-diabetes-mellitus
#10
Huibiao Quan, Huachuan Zhang, Weiping Wei, Tuanyu Fang, Daoxiong Chen, Kaining Chen
The aim of the present study was to explore the effects of various combinations of exenatide, metformin (MET) and biphasic insulin aspart 30 (BIA30) on type 2 diabetes mellitus (T2DM). Two hundred overweight or obese patients newly diagnosed with T2DM were evenly randomized into two groups: A (twice daily for all: Phase I, 5 µg exenatide + 0.5 g MET for 4 weeks, then 10 µg exenatide + 0.5 g MET for 8 weeks; Phase II, 0.5 g MET for 12 weeks; Phase III, 0.3-0.4 U/kg/day BIA30 + 0.5 g MET for 12 weeks) and B (Phases I, II, III matched the phases III, II and I in group A)...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912193/effectiveness-of-a-multifactorial-intervention-based-on-an-application-for-smartphones-heart-healthy-walks-and-a-nutritional-workshop-in-patients-with-type-2-diabetes-mellitus-in-primary-care-emid-study-protocol-for-a-randomised-controlled-trial
#11
Rosario Alonso-Domínguez, Manuel A Gómez-Marcos, Maria C Patino-Alonso, Natalia Sánchez-Aguadero, Cristina Agudo-Conde, Carmen Castaño-Sánchez, Luis García-Ortiz, José I Recio-Rodríguez
INTRODUCTION: New information and communication technologies (ICTs) may promote lifestyle changes, but no adequate evidence is available on their combined effect of ICTs with multifactorial interventions aimed at improving diet and increasing physical activity in patients with type 2 diabetes mellitus (DM2). The primary objective of this study is to assess the effect of a multifactorial intervention to increase physical activity and adherence to Mediterranean diet in DM2. METHODS AND ANALYSIS: Study scope and population: The study will be conducted at 'La Alamedilla' primary care research unit in Salamanca (Spain)...
September 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28903983/ivabradine-in-heart-failure-the-representativeness-of-shift-systolic-heart-failure-treatment-with-the-if-inhibitor-ivabradine-trial-in-a-broad-population-of-patients-with-chronic-heart-failure
#12
Debraj Das, Gianluigi Savarese, Ulf Dahlström, Michael Fu, Jonathan Howlett, Justin A Ezekowitz, Lars H Lund
BACKGROUND: The sinus node inhibitor ivabradine was approved for patients with heart failure (HF) after the ivabradine and outcomes in chronic HF (SHIFT [Systolic Heart Failure Treatment With the IF Inhibitor Ivabradine Trial]) trial. Our objective was to characterize the proportion of patients with HF eligible for ivabradine and the representativeness of the SHIFT trial enrollees compared with those in the Swedish Heart Failure Registry. METHODS AND RESULTS: We examined 26 404 patients with clinical HF from the Swedish Heart Failure Registry and divided them into SHIFT type (left ventricular ejection fraction <40%, New York Heart Association class II-IV, sinus rhythm, and heart rate ≥70 beats per minute) and non-SHIFT type...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28891228/investigating-a-biomarker-driven-approach-to-target-collagen-turnover-in-diabetic-heart-failure-with-preserved-ejection-fraction-patients-effect-of-torasemide-vs-furosemide-on-serum-c-terminal-propeptide-of-procollagen-type-i-drop-pip-trial
#13
Tobias Daniel Trippel, Sophie Van Linthout, Dirk Westermann, Ruhdja Lindhorst, Anja Sandek, Stefanie Ernst, Anna Bobenko, Mario Kasner, Frank Spillmann, Arantxa González, Begoña López, Susana Ravassa, Burkert Pieske, Walter J Paulus, Javier Díez, Frank Edelmann, Carsten Tschöpe
AIM: Heart failure with preserved ejection fraction (HFpEF) is associated with myocardial remodelling including severe pro-fibrotic changes contributing to an increase in left ventricular stiffness and diastolic dysfunction. Serum C-terminal propeptide of procollagen type I (PIP) strongly correlates with the turnover of extracellular cardiac matrix proteins and fibrosis. Torasemide, but not furosemide, was described to reduce collagen type I synthesis in clinically unstable patients with heart failure with reduced ejection fraction...
September 11, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28886529/peroxisome-proliferator-activated-receptors-as-therapeutic-targets-for-heart-failure
#14
REVIEW
Abdelrahman Ibrahim Abushouk, Mostafa Wanees Ahmed El-Husseny, Eshak I Bahbah, Ahmed Elmaraezy, Aya Ashraf Ali, Asmaa Ashraf, Mohamed M Abdel-Daim
Heart failure (HF) is a common clinical syndrome that affects more than 23 million individuals worldwide. Despite the marked advances in its management, the mortality rates in HF patients have remained unacceptably high. Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription regulators, involved in the regulation of fatty acid and glucose metabolism. PPAR agonists are currently used for the treatment of type II diabetes mellitus and hyperlipidemia; however, their role as therapeutic agents for HF remains under investigation...
September 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28885036/postnatal-diet-remodels-hepatic-dna-methylation-in-metabolic-pathways-established-by-a-maternal-high-fat-diet
#15
Laura Moody, Hong Chen, Yuan-Xiang Pan
AIM: We investigate how postweaning diet may modify the epigenetic landscape to meet metabolic demands later in life. METHODS: Sprague-Dawley rats were exposed to a high-fat (HF) diet during gestation and lactation. At weaning, male offspring were placed either on an HF diet (HF/HF) or a control diet (HF/C). Methylation-dependent immunoprecipitation sequencing and methylation-sensitive restriction enzyme sequencing were used to quantify hepatic DNA methylation. RESULTS: Out of the 3966 identified differentially methylated regions, 37% were mapped to gene bodies while 6% fell within promoter or downstream regions...
September 8, 2017: Epigenomics
https://www.readbyqxmd.com/read/28879491/profiling-of-cardio-metabolic-risk-factors-and-medication-utilisation-among-type-ii-diabetes-patients-in-ghana-a-prospective-cohort-study
#16
Eric Adua, Peter Roberts, Samuel Asamoah Sakyi, Francis Agyemang Yeboah, Albert Dompreh, Kwasi Frimpong, Enoch Odame Anto, Wei Wang
BACKGROUND: Type II diabetes mellitus (T2DM) is complicated by multiple cardio-metabolic risk factors. Controlling these factors requires lifestyle modifications alongside utilisation of anti-diabetic medications. Different glucose lowering [(biguanides (BIGs), sulfonylureas (SUAs), thiazolidinediones (TNZ)], lipid lowering (statins), and anti-hypertensive medicines [angiotensin converting enzyme inhibitors (ACEIs), calcium channel blockers (CCBs), angiotensin II receptor blockers (ARBs) and central acting drugs (CADs)] have been approved for controlling hyperglycaemia, dyslipidaemia and hypertension respectively...
September 7, 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28878669/picrorhiza-kurroa-enhances-%C3%AE-cell-mass-proliferation-and-insulin-secretion-in-streptozotocin-evoked-%C3%AE-cell-damage-in-rats
#17
Shiv Kumar, Vikram Patial, Sourabh Soni, Supriya Sharma, Kunal Pratap, Dinesh Kumar, Yogendra Padwad
Autoimmune destruction of insulin producing pancreatic β-cells leads to insulin insufficiency and hyperglycemia in type 1 diabetes mellitus. Regeneration of β-cells is one of the proposed treatment for type 1 diabetes and insulin insufficiency. Picrorhiza kurroa is a medicinal herb and is traditionally being used for the treatment of various diseases. Previous studies reported the hypoglycemic potential of P. kurroa. However, its potential role in β-cell induction in insulin secretion have not been fully investigated...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28872686/weak-bones-in-diabetes-mellitus-an-update-on-pharmaceutical-treatment-options
#18
REVIEW
Daphne P L Lin, Crispin R Dass
OBJECTIVES: Diabetes mellitus is often associated with a number of complications such as nephropathy, neuropathy, retinopathy and foot ulcers. However, weak bone is a diabetic complication that is often overlooked. Although the exact mechanism for weak bones within diabetes mellitus is unclear, studies have shown that the mechanism does differ in both type I (T1DM) and type II diabetes (T2DM). This review, however, investigates the application of mesenchymal stem cells, recombinant human bone morphogenetic protein-2, teriparatide, insulin administration and the effectiveness of a peroxisome proliferator-activated receptor-ϒ modulator, netoglitazone in the context of diabetic weak bones...
September 5, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28858362/the-acute-effect-of-coffee-on-endothelial-function-and-glucose-metabolism-following-a-glucose-load-in-healthy-human-volunteers
#19
Evan A J Boon, Kevin D Croft, Sujata Shinde, Jonathan M Hodgson, Natalie C Ward
A diet rich in plant polyphenols has been suggested to reduce the incidence of cardiovascular disease and type 2 diabetes mellitus, in part, via improvements in endothelial function. Coffee is a rich source of phenolic compounds including the phenolic acid, chlorogenic acid (CGA). The aim of the study was to investigate the effect of coffee as a whole beverage on endothelial function, blood pressure and blood glucose concentration. Twelve healthy men and women were recruited to a randomised, placebo-controlled, cross-over study, with three treatments tested: (i) 18 g of ground caffeinated coffee containing 300 mg CGA in 200 mL of hot water, (ii) 18 g of decaffeinated coffee containing 287 mg CGA in 200 mL of hot water, and (iii) 200 mL of hot water (control)...
September 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28857298/cryptococcosis-in-patients-with-diabetes-mellitus-ii-in-mainland-china-1993-2015
#20
Yingfang Li, Wenjie Fang, Weiwei Jiang, Ferry Hagen, Jia Liu, Lei Zhang, Nan Hong, Yu Zhu, Xiaoguang Xu, Xia Lei, Danqi Deng, Jianping Xu, Wanqing Liao, Teun Boekhout, Min Chen, Weihua Pan
Diabetes mellitus II (DM II) is a newly defined independent factor contributing to the morbidity and mortality of cryptococcosis. This retrospective case analysis aims to explore the epidemiology, clinical profile and strain characteristics of cryptococcosis in Chinese DM II patients. This study included 30 cases of cryptococcosis with DM II occurring from 1993 to 2015 in mainland China. The hospital-based prevalence of cryptococcosis in DM II was 0.21%. The mean age of the patients was 56.1 years (95% confidence interval: 51...
August 30, 2017: Mycoses
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