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diabetes mellitus type II

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https://www.readbyqxmd.com/read/29786669/protein-tyrosine-phosphatase-1b-inhibition-and-glucose-uptake-potentials-of-mulberrofuran-g-albanol-b-and-kuwanon-g-from-root-bark-of-morus-alba-l-in-insulin-resistant-hepg2-cells-an-in-vitro-and-in-silico-study
#1
Pradeep Paudel, Ting Yu, Su Hui Seong, Eun Bi Kuk, Hyun Ah Jung, Jae Sue Choi
Type II diabetes mellitus (T2DM) is the most common form of diabetes and has become a major health problem across the world. The root bark of Morus alba L. is widely used in Traditional Chinese Medicine for treatment and management of diabetes. The aim of the present study was to evaluate the enzyme inhibitory potentials of three principle components, mulberrofuran G ( 1 ), albanol B ( 2 ), and kuwanon G ( 3 ) in M. alba root bark against diabetes, establish their enzyme kinetics, carry out a molecular docking simulation, and demonstrate the glucose uptake activity in insulin-resistant HepG2 cells...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29781744/endurance-training-alters-ykl40-perm1-and-hsp70-skeletal-muscle-protein-contents-in-men-with-type-2-diabetes-mellitus
#2
Christian Brinkmann, Anika Kuckertz, Thorsten Schiffer, Wilhelm Bloch, Hans-Georg Predel, Klara Brixius
BACKGROUND: The fight against type 2 diabetes mellitus (T2DM) is tremendously challenging. This pilot study investigates whether endurance training (3 times per week for 3 months, moderate intensity) can change the skeletal muscle protein contents of chitinase-3-like protein-1 (YKL40), peroxisome proliferator-activated receptor y coactivator-1 and estrogen-related receptor-induced regulator in muscle-1 (PERM1) and heat-shock protein-70 (HSP70), which have been discussed as novel therapeutically relevant targets...
May 21, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29781721/current-prescription-status-of-antihypertensive-drugs-in-japanese-patients-with-hypertension-analysis-by-type-of-comorbidities
#3
Takayuki Ishida, Akinori Oh, Shinzo Hiroi, Yukio Shimasaki, Takuya Tsuchihashi
In 2014, the Japanese Society of Hypertension (JSH) issued revised guidelines for hypertension management. To assess adherence to the guidelines, this retrospective study evaluated the real-world status of antihypertensive drug prescribing for Japanese patients with hypertension, classified by comorbidity: diabetes mellitus, dyslipidemia, gout/hyperuricemia and renal diseases. Data on 59,867 hypertensive patients who received their first prescription for antihypertensive therapy between April 2014 and March 2015, were obtained from a medical insurance claims database for hospitals participating in the Diagnosis Procedure Combination/Per-Diem payment system...
May 21, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29774166/hemostatic-state-augmented-with-platelet-indices-among-sudanese-diabetic-septic-foot
#4
Bashir Abdrhman Bashir, Mohamed Salih Ali
Background: Diabetes mellitus is a very rampant metabolic disorder, particularly type II. It has many complications such as the septic foot. Diabetic septic foot (DSF) patients are at high risk for coagulation abnormalities as well as surgical hazards. Owing to the potential sequelae of coagulation and vascular abnormalities, this work aimed at studying the hemostatic state and platelet indices in diabetes type II patients with septic foot. Methods: A case-control study was conducted during the period from July to September 2017 at Dr...
2018: BMC Hematology
https://www.readbyqxmd.com/read/29773555/prostaglandin-f-2%C3%AE-facilitates-hepatic-glucose-production-through-camkii%C3%AE-p38-foxo1-signaling-pathway-in-fasting-and-obesity
#5
Yuanyang Wang, Shuai Yan, Bing Xiao, Shengkai Zuo, Qianqian Zhang, Guilin Chen, Yu Yu, Di Chen, Qian Liu, Yi Liu, Yujun Shen, Ying Yu
Gluconeogenesis is drastically increased in patients with type 2 diabetes and accounts for increased fasting plasma glucose concentrations. Circulating prostaglandin (PG) F2α is also markedly elevated in diabetes mellitus; however, whether and how PGF2α regulates hepatic glucose metabolism remain unknown. Here, we demonstrated that PGF2α receptor (F-prostanoid receptor; FP) was upregulated in livers of mice upon fasting- and diabetic stress. Hepatic deletion of the FP receptor suppressed fasting-induced hepatic gluconeogenesis, whereas FP overexpression enhanced hepatic gluconeogenesis in mice...
May 17, 2018: Diabetes
https://www.readbyqxmd.com/read/29773093/combined-influence-of-insulin-resistance-and-inflammatory-biomarkers-on-type-2-diabetes-a-population-based-prospective-cohort-study-of-inner-mongolians-in-china
#6
Qiao Yan Qiu, Bei Lei Zhang, Ming Zhi Zhang, Jia Hui Wu, Jing Wen Zhou, Zhu Liang, Yong Hong Zhang, Shao Yan Zhang
This prospective study was designed to examine the combined influence of insulin resistance (IR) and inflammatory biomarker levels on type 2 diabetes mellitus (T2DM) among 1,903 Inner Mongolians. During follow-up, 205 (10.77%) participants developed T2DM, and the incidence of T2DM was higher among subjects with IR, elevated C-reactive protein (CRP), elevated sICAM-1, elevated sE-selectin, or the coexistences of IR with elevated CRP, elevated sICAM-1, elevated sE-selectin, and elevated angiotensin II (all P < 0...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29772226/potential-role-of-peroxisome-proliferator-activated-receptor-gamma-activation-on-serum-visfatin-and-trace-elements-in-high-fat-diet-induced-type-2-diabetes-mellitus
#7
Arshia Tabassum, Syeda Nuzhat Fatima Zaidi, Kausar Yasmeen, Tabassum Mahboob
AIMS: Electrolytes and trace elements dysregulation play an important role in the progression of obesity and diabetes complications. The present study was designed to evaluate the insulin sensitizing effects of peroxisomes proliferators activated receptor gamma (PPAR-γ) agonist on trace elements in obesity induced type 2 diabetes mellitus and correlate with serum visfatin. MATERIALS AND METHODS: Wistar rats were categorized into five groups. Group I served as control; Group II fed on high fat diet (HFD); Group III fed on HFD and treated with rosiglitazone (3 mg/kg) for 7 days; Group IV were T2DM rats induce by HFD and low dose of streptozotocin (i...
May 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29769484/prevalence-of-non-alcoholic-fatty-liver-disease-and-its-biochemical-predictors-in-patients-with-type-2-diabetes-mellitus
#8
M A Kabir, M Z Uddin, N I Siddiqui, I H Robi, M S Malek, M S Islam, S Rahman, M S Hossain, S K Mahapatra, M J Alam, F Ahmad, M S Alam, M A Islam
Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver condition in the Western world and it is commonly associated with type 2 diabetes mellitus (DM). The aim of this study to determine the prevalence of NAFLD and identify the predisposing factors in type 2 DM patients with NAFLD. Total of 258 patients of type 2 DM were included in this observational study in the Department of Medicine, Mymensingh Medical College Hospital, Mymensingh, Bangladesh from 11th May 2013 to 11th November 2013...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769460/circulating-surfactant-protein-d-is-associated-with-clinical-outcomes-in-peripheral-artery-disease-patients-following-endovascular-therapy
#9
Yoichiro Otaki, Tetsu Watanabe, Hiroki Takahashi, Takayuki Sugai, Miyuki Yokoyama, Satoshi Nishiyama, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Tamon Yamanaka, Isao Kubota, Masafumi Watanabe
BACKGROUND: Peripheral artery disease (PAD) is a risk factor for the development of cardiovascular disease and death. Surfactant protein-D (SP-D) is a 43-kDa protein secreted from type II pneumocytes in the lungs. Recent studies have demonstrated that circulating SP-D plays a key role in the development of atherosclerosis and is related to clinical outcomes in patients with ischemic heart disease. However, it remains unclear whether circulating SP-D is associated with clinical outcomes in patients with PAD...
May 17, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29755788/factors-associated-with-participation-in-pulmonary-tuberculosis-screening-using-chest-x-ray-among-diabetes-mellitus-type-ii-patients-in-denpasar-bali-indonesia
#10
I Gusti Ngurah Edi Putra, Putu Ayu Swandewi Astuti, I Ketut Suarjana, Ketut Hari Mulyawan, I Made Kerta Duana, Ni Made Dian Kurniasari, I Wayan Gede Artawan Eka Putra
Diabetes mellitus (DM) increases the risk of developing pulmonary tuberculosis (TB) disease. Therefore, pulmonary TB screening among DM patients is essential. This study aimed to identify factors associated with participation of DM type II patients in pulmonary TB screening using chest X-ray. This was a cross-sectional analytic study and was part of TB-DM screening study in Denpasar, Bali, Indonesia. The sample consisted of 365 DM type II patients selected by quota sampling among DM type II patients joining the screening program from January until March 2016 in 11 public health centres in Denpasar...
2018: Tuberculosis Research and Treatment
https://www.readbyqxmd.com/read/29755520/efficacy-safety-and-quality-of-treatment-satisfaction-of-premixed-human-and-analogue-insulin-regimens-in-a-large-cohort-of-type-2-diabetic-patients-progens-benefit-observational-study
#11
Katarzyna Nabrdalik, Hanna Kwiendacz, Tomasz Sawczyn, Andrzej Tomasik, Michał Kukla, Małgorzata Masierek, Janusz Gumprecht
Diabetes is a lifelong course disease, so insulin treatment has to be effective and safe, and patients should be satisfied with it. We aimed to compare efficacy, safety, and quality of treatment satisfaction of human and premixed analogue insulin among 3264 patients (53.58% women) with type 2 diabetes mellitus (T2DM) in a real-life environment. 2493 patients (62.77%) had been assigned to group I where before the inclusion into the study the treatment regimen has been changed from analogue to human premixed insulin and 771 patients (37...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29753766/licorice-flavonoid-oil-enhances-muscle-mass-in-kk-a-y-mice
#12
Yasukiyo Yoshioka, Yoko Yamashita, Hideyuki Kishida, Kaku Nakagawa, Hitoshi Ashida
AIMS: Muscle mass is regulated by the balance between the synthesis and degradation of muscle proteins. Loss of skeletal muscle mass is associated with an increased risk of developing metabolic diseases such as obesity and type 2 diabetes mellitus. The aim of this study was to clarify the effects of licorice flavonoid oil on muscle mass in KK-Ay /Ta mice. MAIN METHODS: Male genetically type II diabetic KK-Ay /Ta mice received 0, 1, or 1.5 g/kg BW of licorice flavonoid oil by mouth once daily for 4 weeks...
May 10, 2018: Life Sciences
https://www.readbyqxmd.com/read/29751547/the-relationship-between-diabetes-mellitus-and-respiratory-function-in-patients-eligible-for-coronary-artery-bypass-grafting
#13
Aleksandra Szylińska, Mariusz Listewnik, Żaneta Ciosek, Magdalena Ptak, Anna Mikołajczyk, Wioletta Pawlukowska, Iwona Rotter
Introduction: Spirometry performed prior to surgery provides information on the types of lung disorders in patients. The purpose of this study was to look for a relationship between the prevalence of diabetes and spirometry parameters. Material and Methods: The study was conducted in patients with coronary artery disease who were eligible for an isolated coronary artery bypass graft in 2013. The study group included 367 patients (287 men and 80 women) aged 68.7 ± 8.4 years. They were divided into those with diagnosed diabetes (group I, n = 138, 37...
May 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29751237/current-anti-diabetic-agents-and-their-molecular-targets-a-review
#14
REVIEW
Nagaraju Kerru, Ashona Singh-Pillay, Paul Awolade, Parvesh Singh
Diabetes mellitus is a medical condition characterized by the body's loss of control over blood sugar. The frequency of diagnosed cases and consequential increases in medical costs makes it a rapidly growing chronic disease that threatens human health worldwide. In addition, its unnerving statistical projections are perilous to both the economy of the nation and man's life expectancy. Type-I and type-II diabetes are the two clinical forms of diabetes mellitus. Type-II diabetes mellitus (T2DM) is illustrated by the abnormality of glucose homeostasis in the body, resulting in hyperglycemia...
May 3, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29750254/clinical-significance-of-atrial-kick
#15
Vinod Namana, Sushilkumar Satish Gupta, Nitin Sabharwal, Gerald Hollander
A 68-year-old man with a history of diabetes mellitus type II, hypertension and active smoking was transferred to our hospital from a nearby hospital for coronary artery bypass graft (CABG) surgery after suffering a complicated inferior wall myocardial infarction (IWMI). Post the initial angioplasty, the patient developed in-stent thrombosis and became hypotensive with a systolic blood pressure < 90 mmHg. After hemodynamic stability was achieved he was transferred to our hospital. During his stay, the cardiac monitor showed fluctuations in his blood pressure with a drop in systolic blood pressure by 10 to 15 mmHg and diastolic blood pressure by 10 mmHg when he developed atrioventricular (AV) dissociation during an idioventricular rhythm...
May 10, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29745911/clinical-case-of-type-2-diabetes-remission
#16
S Mustafayeva, V Mirzazada
Authors present a clinical case of a 48-year-old male patient diagnosed with type 2 diabetes mellitus (with insulin resistance), obesity class II, alcoholic liver disease and dyslipidemia, who was able to achieve a T2DM remission after lifestyle modification by using low-calorie (1500-1800 kcal), rather than extreme diet, and a significant increase in physical activity. This result demonstrates that not only biofuel intake decrease, but also increase of biofuel consumption (in optimal situation all together) may be a really effective way of achieving diabetes remission in obese patients...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29744369/identification-of-protein-kinase-c-isoforms-involved-in-type-1-diabetic-encephalopathy-in-mice
#17
Jiayin Zheng, Yue Wang, Song Han, Yanlin Luo, Xiuli Sun, Ning Zhu, Li Zhao, Junfa Li
Diabetic encephalopathy is a complication of diabetes mellitus characterized by impaired cognitive functions. Protein kinase C (PKC) isoforms are rarely reported on diabetic encephalopathy, although they have been believed to play crucial roles in other diabetic complications. In this study, streptozotocin- (STZ-) induced diabetic mice were found to exhibit learning and memory deficits in the Morris water maze test. Meanwhile, the expression of cPKC β II, nPKC ε , and cPKC γ did not change in the hippocampus, cortex, and striatum at 2 and 8 weeks after STZ injection...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29738868/bsmi-single-nucleotide-polymorphism-in-vitamin-d-receptor-gene-is-associated-with-decreased-circulatory-levels-of-serum-25-hydroxyvitamin-d-among-micro-and-macrovascular-complications-of-type-2-diabetes-mellitus
#18
Krishnamoorthy Ezhilarasi, Umapathy Dhamodharan, Viswanathan Vijay
Vitamin D Receptor (VDR) gene single nucleotide polymorphism (SNP) in the intron 8 is a well characterized SNP which has previously been linked to various diseases including Type 2 Diabetes Mellitus (T2DM). However, the association of this SNP with micro and macrovascular complications of T2DM remains poorly studied. Hence, the present study was designed to investigate the association of VDR gene SNP with complications of T2DM (disease phenotype) and correlated it with the serum levels of (25[OH]D) (intermediate phenotype) along with other clinical risk factors of T2DM...
May 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29737299/intervention-and-effect-analysis-of-achyranthes-bidentata-blume-combined-with-aerobic-exercise-to-interfere-with-type-2-diabetes
#19
Chi Ma, Chengtao Zhang, Xin Li
With the continuous progress of traditional Chinese medicine extraction technology in recent years, the active components of traditional Chinese medicine have been continuously extracted and analyzed. In this paper, the authors studied the effect of aerobic exercise combined with the extract of the Achyranthes bidentata on the serum indexes of T2DM rats. Through systematic analysis of measurement indexes of Chinese medicine treatment group, we found that all indexes of FPG, INS, NOXs, ROS and SOD all showed a marked improvement, which fully proved the effect of Achyranthes bidentata extract on improving the condition of rats with type 2 diabetes mellitus...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29735466/intervention-and-effect-analysis-of-achyranthes-bidentata-blume-combined-with-aerobic-exercise-to-interfere-with-type-2-diabetes
#20
Chi Ma, Chengtao Zhang, Xin Li
With the continuous progress of traditional Chinese medicine extraction technology in recent years, the active components of traditional Chinese medicine have been continuously extracted and analyzed. In this paper, the authors studied the effect of aerobic exercise combined with the extract of the Achyranthes bidentata on the serum indexes of T2DM rats. Through systematic analysis of measurement indexes of Chinese medicine treatment group, we found that all indexes of FPG, INS, NOXs, ROS and SOD all showed a marked improvement, which fully proved the effect of Achyranthes bidentata extract on improving the condition of rats with type 2 diabetes mellitus...
May 2018: Pakistan Journal of Pharmaceutical Sciences
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