Edmara T P Bergamo, Lukasz Witek, Ilana Santos Ramalho, Adolfo Coelho de Oliveira Lopes, Vasudev Vivekanand Nayak, Andrea Torroni, Blaire V Slavin, Estevam A Bonfante, Kathryn E Uhrich, Dana T Graves, Paulo G Coelho
To develop a peri-implantitis model in a Gottingen minipig and evaluate the effect of local application of salicylic acid poly(anhydride-ester) (SAPAE) on peri-implantitis progression in healthy, metabolic syndrome (MS), and type-2 diabetes mellitus (T2DM) subjects. Eighteen animals were allocated to three groups: (i) control, (ii) MS (diet for obesity induction), and (iii) T2DM (diet plus streptozotocin for T2DM induction). Maxillary and mandible premolars and first molar were extracted. After 3 months of healing, four implants per side were placed in both jaws of each animal...
April 9, 2024: ACS Biomaterials Science & Engineering