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https://www.readbyqxmd.com/read/28092435/microbial-biotransformation-of-five-pyrrolidinophenone-type-psychoactive-substances-in-wastewater-and-a-wastewater-isolated-pseudomonas-putida-strain
#1
Marie Mardal, Markus Bischoff, María Ibáñez, Ulla Ruffing, Félix Hernández, Markus R Meyer
Wastewater-based epidemiology (WBE) employs the analysis of wastewater to detect and quantify drug use and discharge within a community. In this work, transformation products (TP) by microbes in the environment were identified after incubations in wastewater and an isolated microbial strain. The microbial strain was isolated from an enrichment culture of wastewater supplemented with 3,4-methylenedioxy-pyrovalerone, and identified by matrix assisted laser desorption - time of flight mass spectrometry as Pseudomonas putida (P...
January 16, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28091431/determinants-of-quality-of-life-among-community-dwelling-persons-with-spinal-cord-injury-a-path-analysis
#2
End Ekechukwu, J O Ikrechero, A O Ezeukwu, A V Egwuonwu, L Umar, U M Badaru
CONTEXT: Recent advancement in technology and medical care has resulted in an increase not only in disability arising from spinal cord injury (SCI) but also its attendant challenges such as poor quality of life (QoL). AIM: To test a theoretical model of predictors of QoL among persons with SCI. SETTINGS AND DESIGN: Study was conducted in the South Eastern Nigeria. A longitudinal study design was employed. MATERIALS AND METHODS: A total of 64 persons with SCI discharged from in-hospital admission participated in this study...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28089727/clinical-characteristics-associated-with-days-to-discharge-among-patients-admitted-with-a-primary-diagnosis-of-lower-limb-cellulitis
#3
Amit Garg, Jonathan Lavian, Gloria Lin, Cristina Sison, Michael Oppenheim, Bonnie Koo
BACKGROUND: Clinicians have limited ability to classify risk of prolonged hospitalization among patients with lower limb cellulitis. OBJECTIVE: We sought to identify characteristics associated with days to discharge and prolonged stay. METHODS: We conducted retrospective cohort analysis including patients admitted with a primary diagnosis of lower limb cellulitis at community and tertiary hospitals. RESULTS: There were 4224 admissions for lower limb cellulitis among 3692 patients...
January 12, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28088924/microbiology-of-otitis-media-in-indigenous-australian-children-review
#4
J Jervis-Bardy, A S Carney, R Duguid, A J Leach
OBJECTIVES: To review research addressing the polymicrobial aetiology of otitis media in Indigenous Australian children in order to identify research gaps and inform best practice in effective prevention strategies and therapeutic interventions. METHODS: Literature review. RESULTS: Studies of aspirated middle-ear fluid represented a minor component of the literature reviewed. Most studies relied upon specimens from middle-ear discharge or the nasopharynx...
January 16, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28088715/micropollutant-induced-tolerance-of-in-situ-periphyton-establishing-causality-in-wastewater-impacted-streams
#5
Ahmed Tlili, Juliane Hollender, Cornelia Kienle, Renata Behra
The overarching aim of this field study was to examine causal links between in-situ exposure to complex mixtures of micropollutants from wastewater treatment plants and effects on freshwater microbial communities in the receiving streams. To reach this goal, we assessed the toxicity of serial dilutions of micropollutant mixtures, extracted from deployed passive samplers at the discharge sites of four Swiss wastewater treatment plants, to in situ periphyton from upstream and downstream of the effluents. On the one hand, comparison of the sensitivities of upstream and downstream periphyton to the micropollutant mixtures indicated that algal and bacterial communities composing the periphyton displayed higher tolerance towards these micropollutants downstream than upstream...
January 7, 2017: Water Research
https://www.readbyqxmd.com/read/28086871/the-integrated-care-pathway-for-post-stroke-patients-icapps-a-shared-care-approach-between-stakeholders-in-areas-with-limited-access-to-specialist-stroke-care-services
#6
Aznida Firzah Abdul Aziz, Nor Azlin Mohd Nordin, Mohd Fairuz Ali, Noor Azah Abd Aziz, Saperi Sulong, Syed Mohamed Aljunid
BACKGROUND: Lack of intersectoral collaboration within public health sectors compound efforts to promote effective multidisciplinary post stroke care after discharge following acute phase. A coordinated, primary care-led care pathway to manage post stroke patients residing at home in the community was designed by an expert panel of specialist stroke care providers to help overcome fragmented post stroke care in areas where access is limited or lacking. METHODS: Expert panel discussions comprising Family Medicine Specialists, Neurologists, Rehabilitation Physicians and Therapists, and Nurse Managers from Ministry of Health and acadaemia were conducted...
January 13, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28086867/process-evaluation-of-an-integrated-care-pathway-in-geriatric-rehabilitation-for-people-with-complex-health-problems
#7
Irma H J Everink, Jolanda C M van Haastregt, Jose M C Maessen, Jos M G A Schols, Gertrudis I J M Kempen
BACKGROUND: An integrated care pathway in geriatric rehabilitation was developed to improve coordination and continuity of care for community-living older adults in the Netherlands, who go through the process of hospital admission, admission to a geriatric rehabilitation facility and discharge back to the home situation. This pathway is a complex intervention and is focused on improving communication, triage and transfers of patients between the hospital, geriatric rehabilitation facility and primary care organisations...
January 13, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28077376/dietary-intake-and-peripheral-arterial-disease-incidence-in-middle-aged-adults-the-atherosclerosis-risk-in-communities-aric-study
#8
Rachel P Ogilvie, Pamela L Lutsey, Gerardo Heiss, Aaron R Folsom, Lyn M Steffen
BACKGROUND: Peripheral arterial disease (PAD) is a costly source of morbidity and mortality among older persons in the United States. Dietary intake plays a role in the development of atherosclerotic cardiovascular disease; however, few studies have examined the relation of food intake or dietary patterns with PAD. OBJECTIVE: We examined the relation between habitual dietary intake at midlife and incident PAD over ∼20 y of follow-up. DESIGN: Among 14,082 participants enrolled in the ARIC (Atherosclerosis Risk in Communities) Study initially free of PAD, dietary intake was assessed at baseline in 1987-1989 by using a modified Harvard food-frequency questionnaire...
January 11, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28072593/use-of-benzodiazepines-and-related-drugs-is-associated-with-a-risk-of-stroke-among-persons-with-alzheimer-s-disease
#9
Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Piia Lavikainen, Anna-Maija Tolppanen, Reijo Sund, Jari Tiihonen, Sirpa Hartikainen
The aim of our study was to investigate the risk of any, ischemic, and hemorrhagic stroke associated with incident benzodiazepine and related drug (BZDR) use among community-dwelling individuals with Alzheimer's disease (AD). Data from the MEDALZ cohort including all community-dwelling persons newly diagnosed with AD between 2005 and 2011 in Finland were utilized. Incident BZDR users were identified with a 1-year washout period for previous use. Persons with a previous stroke were excluded, resulting in a final study sample of 45 050 individuals...
January 7, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28070670/the-impact-of-pneumococcal-conjugate-vaccine-on-community-acquired-pneumonia-hospitalizations-in-children-with-comorbidity
#10
Ellinor Sterky, Rutger Bennet, Ann Lindstrand, Margareta Eriksson, Anna Nilsson
: The burden of community-acquired pneumonia (CAP) in high-income countries is still significant. The introduction of pneumococcal conjugate vaccines (PCV) has reduced the overall need for hospitalization for CAP. However, it is not clear whether children with underlying disease also have benefitted from the PCV immunization programme. Children 0 to <5 years of age hospitalized with CAP and discharged with an ICD-10 code of J13-J18.9 between November 1, 2005, and April 30, 2007 (pre-vaccination period), and November 1, 2010, and April 30, 2012 (post-vaccination period), were eligible for this study...
January 9, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28069851/less-intense-postacute-care-better-outcomes-for-enrollees-in-medicare-advantage-than-those-in-fee-for-service
#11
Peter J Huckfeldt, José J Escarce, Brendan Rabideau, Pinar Karaca-Mandic, Neeraj Sood
Traditional fee-for-service (FFS) Medicare's prospective payment systems for postacute care provide little incentive to coordinate care or control costs. In contrast, Medicare Advantage plans pay for postacute care out of monthly capitated payments and thus have stronger incentives to use it efficiently. We compared the use of postacute care in skilled nursing and inpatient rehabilitation facilities by enrollees in Medicare Advantage and FFS Medicare after hospital discharge for three high-volume conditions: lower extremity joint replacement, stroke, and heart failure...
January 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28068783/clinical-pharmacist-management-of-bacteremia-in-a-community-hospital-emergency-department
#12
C Dustin Waters, Bryce J Bitton, Annie Torosyan, Kevin P Myers
BACKGROUND: Bacteremia is a serious condition that leads to high morbidity and mortality. Data describing pharmacist involvement in the management of bacteremia in the emergency department are lacking. OBJECTIVE: To determine if pharmacist involvement in the management of bacteremia in the emergency department (ED) led to an increase in appropriate treatment of bacteremia as well as improvements in patient outcomes. METHODS: The primary outcome of this retrospective cohort study was the rate of appropriate treatment of bacteremia...
January 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28067568/improving-community-prescribing-of-post-fracture-denosumab-after-discharge
#13
Helen Wood, Harriet Lewis, Rachael Ward, Tarun Solanki, Prabhath Fernando
BACKGROUND: In the UK, denosumab is usually started by hospital clinicians and continued by primary care physicians in the community, but in the authors' region denosumab is a 'green light' drug, only prescribed by the primary care team. The authors suspected that a proportion of patients who were recommended to start the drug after a neck of femur fracture were not receiving this on discharge. They aimed to improve the prescribing of denosumab by implementing a quality improvement project...
January 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28063827/taxonomic-and-functional-diversity-of-a-coastal-planktonic-bacterial-community-in-a-river-influenced-marine-area
#14
Stefan Thiele, Michael Richter, Cecilia Balestra, Frank Oliver Glöckner, Raffaella Casotti
The Gulf of Naples is a dynamical area with intense exchanges between offshore oligotrophic and coastal eutrophic waters with frequent freshwater inputs. The Sarno River, one of the most polluted rivers in Europe, strongly contributes to the pollution of the area, discharging high amounts of heavy metals and organic wastes from heavily cultivated and industrial areas. This paper reports on the diversity and community structure of the marine residential Bacteria and Archaea of the Gulf of Naples in an area close to the river Sarno plume and investigates their small-scale taxonomic diversity and expression patterns as a proxy of potential metabolic activity using metagenomics and metatranscriptomics...
January 4, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28063294/the-effect-of-coagulants-and-antiscalants-discharged-with-seawater-desalination-brines-on-coastal-microbial-communities-a-laboratory-and-in-situ-study-from-the-southeastern-mediterranean
#15
Natalia Belkin, Eyal Rahav, Hila Elifantz, Nurit Kress, Ilana Berman-Frank
Desalination outflows frequently discharge brine containing coagulants and antiscalants (e.g. Iron-hydroxides and polyphosphonates) to the coastal environment. Here we examined changes in composition and productivity of natural microbial coastal communities in experimental mesocosms treated with either iron-hydroxide (Fe), polyphosphonate (Pn), or a combination of high salinities with both chemicals (All). Within 2 h of addition Fe already altered the microbial community composition, enhanced the bacterial production (BP) and cell specific production (BP/BA), and decreased primary production...
December 10, 2016: Water Research
https://www.readbyqxmd.com/read/28061426/impacts-of-environmental-and-anthropogenic-stresses-on-macrozoobenthic-communities-in-jinhae-bay-korea
#16
Hanna Bae, Jung-Ho Lee, Sung Joon Song, Jinsoon Park, Bong-Oh Kwon, Seongjin Hong, Jongseong Ryu, Kyungsik Choi, Jong Seong Khim
In this study, spatiotemporal dynamics of macrofaunal assemblages and their associations with environmental conditions were examined in Jinhae Bay (10 sites), where the obvious sources of pollution including industries, oyster farms (hanging cultures), and municipal discharges has surrounded. The survey had performed over five consecutive seasons in 2013-2014. Target sedimentary variables included grain size, organic content, C/N ratio, carbon and nitrogen stable isotope ratios, and some heavy metals. Five ecological quality indices (EcoQ) were calculated from the benthic community data to evaluate ecological qualities in site-specific manner...
December 27, 2016: Chemosphere
https://www.readbyqxmd.com/read/28060432/should-social-value-obligations-be-local-or-global
#17
Rahul Nayak, Seema K Shah
According to prominent bioethics scholars and international guidelines, researchers and sponsors have obligations to ensure that the products of their research are reasonably available to research participants and their communities. In other words, the claim is that research is unethical unless it has local social value. In this article, we argue that the existing conception of reasonable availability should be replaced with a social value obligation that extends to the global poor (and not just research participants and host communities)...
February 2017: Bioethics
https://www.readbyqxmd.com/read/28059786/death-of-dementia-patients-in-psychiatric-hospitals-and-regional-supply-of-psychiatric-services-study-of-the-national-data-from-1996-to-2014-in-japan
#18
Miharu Nakanishi, Junko Niimura, Syudo Yamasaki, Atsushi Nishida
BACKGROUND: Japan designates psychiatric inpatient care for behavior management of individuals with dementia and for helping dementia patients discharge to home. However, there has been no examination of the effectiveness of this strategy. OBJECTIVE: The present study investigated the association between dementia and the discharge destination of patients in psychiatric hospitals. METHODS: Data from the National Patient Survey, which is a nationally representative cross-sectional survey of inpatient care, were used...
December 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28058799/impact-of-asd-traits-on-treatment-outcomes-of-eating-disorders-in-girls
#19
Catherine S Stewart, Fiona S McEwen, Anna Konstantellou, Ivan Eisler, Mima Simic
Evidence links high levels of Autism Spectrum Disorder Traits in women with chronicity of anorexia nervosa. This study reports through clinical audit the impact of ASD traits on treatment outcomes of girls who were referred for treatment in a specialist eating disorder service. Presence of current, but not early childhood, ASD traits was elevated in comparison with previously reported community samples. Current ASD traits were correlated with emotional disorders and with need for treatment augmentation (psychiatric inpatient or day patient admission), but this relationship was not significant after the contribution of depression had been controlled for...
January 6, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/28057653/hospitalisation-with-community-acquired-pneumonia-among-patients-with-type-2-diabetes-an-observational-population-based-study-in-spain-from-2004-to-2013
#20
Ana López-de-Andrés, Javier de Miguel-Díez, Isabel Jiménez-Trujillo, Valentín Hernández-Barrera, José M de Miguel-Yanes, Manuel Méndez-Bailón, Napoleón Pérez-Farinós, Miguel Á Ngel Salinero-Fort, Rodrigo Jiménez-García
OBJECTIVES: To describe trends in the incidence and outcomes of community-acquired pneumonia (CAP) hospitalisations among patients with or without diabetes in Spain (2004-2013). DESIGN: Retrospective, observational study using the Spanish National Hospital Discharge Database (Conjunto Mínimo Básico de Datos (CMBD)). SETTING: Spain. PARTICIPANTS: We used national hospital discharge data to select all hospital admissions for CAP...
January 5, 2017: BMJ Open
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