Laura Andreoli, Francesca Regola, Alessia Caproli, Francesca Crisafulli, Micaela Fredi, Maria-Grazia Lazzaroni, Cecilia Nalli, Silvia Piantoni, Sonia Zatti, Franco Franceschini, Angela Tincani
This review focuses on the management of reproductive issues in women who have antiphospholipid syndrome (APS) or are carriers of antiphospholipid antibodies (aPL). The importance of aPL detection during preconception counselling relies on their pathogenic potential for placental insufficiency and related obstetric complications. The risk of adverse pregnancy outcomes can be minimized by individualized risk stratification and tailored treatment aimed at preventing placental insufficiency. Combination therapy of low-dose acetylsalicylic acid and heparin is the mainstay of prophylaxis during pregnancy; immunomodulation, especially with hydroxychloroquine, should be considered in refractory cases...
February 6, 2024: Rheumatology