keyword
MENU ▼
Read by QxMD icon Read
search

Pharmacologic study

keyword
https://www.readbyqxmd.com/read/29906814/magnoflorine-enhances-lps-activated-pro-inflammatory-responses-via-myd88-dependent-pathways-in-u937-macrophages
#1
Md Areeful Haque, Ibrahim Jantan, Hemavathy Harikrishnan, Siti Mariam Abdul Wahab
Magnoflorine, a major bioactive metabolite isolated from Tinospora crispa, has been reported for its diverse biochemical and pharmacological properties. However, there is little report on its underlying mechanisms of action on immune responses, particularly on macrophage activation. In this study, we aimed to investigate the effects of magnoflorine, isolated from T. crispa on the pro-inflammatory mediators generation induced by LPS and the concomitant NF- κ B, MAPKs, and PI3K-Akt signaling pathways in U937 macrophages...
June 15, 2018: Planta Medica
https://www.readbyqxmd.com/read/29906718/review-adjunctive-pharmacologic-approaches-for-benzodiazepine-tapers
#2
REVIEW
Justine W Welsh, Valeria Tretyak, R Kathryn McHugh, Roger D Weiss, Olivera Bogunovic
BACKGROUND: Many patients require discontinuation of benzodiazepines due to a reduction in drug efficacy over time, the development of a sedative use disorder, or unwanted side effects. Benzodiazepine discontinuation can pose a significant challenge for prescribing clinicians due to potential withdrawal symptoms and a recurrence of psychiatric complaints. METHODS: A PubMed literature search was conducted using the medical subject heading of benzodiazepines in combination with the following key words: discontinuation, withdrawal, detoxification, cessation, dependence, addiction, substance use disorders, or long term...
May 31, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29906649/identification-of-new-drug-like-compounds-from-millets-as-xanthine-oxidoreductase-inhibitors-for-treatment-of-hyperuricemia-a-molecular-docking-and-simulation-study
#3
Rajesh Kumar Pathak, Ayushi Gupta, Rohit Shukla, Mamta Baunthiyal
Xanthine oxidoreductase plays an important role in formation of uric acid and its regulation during purine catabolism. Uncontrolled expression of this enzyme is responsible for overproduction and deposition of uric acid in blood that is potentially injurious because it can breakdown DNA and protein molecules, triggering many diseases. Human Xanthine oxidoreductase (HsXOR) is considered to be a pharmacological target for the treatment of hyperuricemia. Many of the HsXOR-inhibitor drugs such as Febuxostat and Allopurinol are known to have significant adverse effects...
May 28, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29906642/the-effect-of-simethicone-on-postoperative-ileus-in-patients-undergoing-colorectal-surgery-spot-a-randomized-controlled-trial
#4
Jeremy E Springer, Shiraz Elkheir, Cagla Eskicioglu, Aristithes G Doumouras, Stephen Kelly, Ilun Yang, Shawn Forbes
BACKGROUND: Postoperative ileus is a poorly understood multifactorial outcome following colorectal surgery that presents significant clinical challenges and contributes to increased morbidity, length of stay, and healthcare cost. To date, there are few pharmacological interventions that shorten the duration of postoperative ileus. OBJECTIVE: This study is the first to evaluate the efficacy of simethicone in treating postoperative ileus symptoms in patients undergoing colorectal surgery...
June 12, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29906556/antinociceptive-effect-of-inhalation-of-the-essential-oil-of-bergamot-in-mice
#5
Damiana Scuteri, Michele Crudo, Laura Rombolà, Chizuko Watanabe, Hirokazu Mizoguchi, Shinobu Sakurada, Tsukasa Sakurada, Rosaria Greco, Maria Tiziana Corasaniti, Luigi Antonio Morrone, Giacinto Bagetta
Bergamot essential oil (BEO) has proven wide evidence of pharmacological antinociceptive effectiveness both in nociceptive and in neuropathic pain models. The antinociceptive properties of BEO for inhalation have not been investigated. The purpose of this study is to evaluate the effects of the inhalation of BEO on formalin-induced nociceptive response in mice. Male ddY-strain mice (Japan SLC, Hamamatsu, Japan) of 23-25 g of weight at the time the experiments underwent the formalin test. Twenty μL of formalin (2% in saline) were administered into the plantar surface of the mice hindpaw and the time of licking/biting was observed and recorded at intervals of 5 min...
June 12, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29906553/influence-of-the-dissociation-rate-constant-on-the-intra-tumor-distribution-of-antibody-drug-conjugate-against-tissue-factor
#6
Ryo Tsumura, Shino Manabe, Hiroki Takashima, Yoshikatsu Koga, Masahiro Yasunaga, Yasuhiro Matsumura
Antibody-drug conjugates (ADCs) are currently considered to be promising agents for cancer therapy. However, especially in solid tumors, the uneven distribution of ADCs would decrease their efficacy in clinical studies. We suggest that in addition to optimizing ADC components, such as the linker structure and anticancer agent, it is necessary to consider the distribution of the ADC within tumor tissue. In this study, we established three kinds of anti-tissue factor (TF) ADCs: 1849ADC with a low kd , 444ADC with an intermediate kd , and 1084ADC with a high kd ...
June 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29906494/dihydronortanshinone-a-natural-product-alleviates-lps-induced-inflammatory-response-through-nf-%C3%AE%C2%BAb-mitochondrial-ros-and-mapk-pathways
#7
Xiaxia Wu, Hongwei Gao, Ying Hou, Jie Yu, Wen Sun, Ying Wang, Xiaoyan Chen, Yulin Feng, Qiong-Ming Xu, Xiuping Chen
Inflammation is considered to be the common pathophysiological basis for a series of diseases. Documented data showed the anti-inflammatory effects of Salvia miltiorrhiza Bunge (Danshen), a traditional herb. The pharmacological activities of dihydronortanshinone (DNT), a tanshinone isolated from Danshen, remain unknown. In this study, the anti-inflammatory effects and underlying mechanisms of DNT were investigated with a lipopolysaccharide (LPS)-induced RAW264.7 macrophage model. DNT significantly suppressed LPS-induced inflammatory mediators such as nitrite oxide (NO), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), inducible nitric oxide synthase (iNOS)...
June 12, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29905792/yeast-as-a-tool-to-identify-anti-aging-compounds
#8
Andreas Zimmermann, Sebastian Hofer, Tobias Pendl, Katharina Kainz, Frank Madeo, Didac Carmona-Gutierrez
In the search for interventions against aging and age-related diseases, biological screening platforms are indispensable tools to identify anti-aging compounds among large substance libraries. The budding yeast, Saccharomyces cerevisiae, has emerged as a powerful chemical and genetic screening platform, as it combines a rapid workflow with experimental amenability and the availability of a wide range of genetic mutant libraries. Given the amount of conserved genes and aging mechanisms between yeast and human, testing candidate anti-aging substances in yeast gene-deletion or overexpression collections, or de novo derived mutants, has proven highly successful in finding potential molecular targets...
September 1, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29905574/mechanisms-leading-to-t-cell-activation-in-drug-hypersensitivity
#9
Xiaoli Meng, Daniel Yerly, Dean J Naisbitt
PURPOSE OF REVIEW: Delayed-type or nonimmediate drug hypersensitivity reactions often involve the activation of drug-specific T cells. As such, the molecular initiating event is an interaction between HLA proteins, HLA-binding peptides and the drug. For many years, the formation of covalently modified drug protein adducts was assumed to be a prerequisite for T-cell activation. The purpose of this article is to review recent studies using human PBMC, T-cell lines and clones, which show that drugs are in fact loaded onto HLA molecules in different forms to activate T cells...
June 13, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29905566/-evaluation-of-neuroprotective-activity-of-complex-impact-of-magnesium-of-sulfate-lamotrygine-and-n-acetylcysteine-under-conditions-of-combined-normobaric-hypoxia-with-ligation-of-right-carotid-artery-in-rats
#10
M Samsonia, M Kandelaki, N Baratashvili
Cerebrovascular diseases of ischemic origin still remain the leading cause of death and disability of the population. In acute cerebral discirculation conditions, anaerobic glycolysis is activated, ATP formation rate decreases, the ion pumps work is disrupted and superoxide radicals are formed. Eventually, ionic asymmetry leads to the cytotoxic and vasogenic brain edema. Therefore, it is extremely important to induce simultaneous (complex) effect of medications on the key mechanisms of neuronal damage in process of survival of brain cells during acute ischemic stroke...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905565/energy-profile-of-rats-with-overactive-bladder-syndrome-pharmacologically-corrected-with-quercetin
#11
O Iatsyna, N Diachkova, M Kharkhota, F Kostev
We studied the effect of Quercetin on energy profile of erythrocytes of rats with the overactive bladder syndrome. It was shown that animal models with the subject pathology demonstrated alteration of quantitative composition of the adenine nucleotide system in erythrocytes. Abrupt decrease of the total concentration of adenyl nucleotides and ATP compared to the intact group of animals was noted in the study. Administration of Quercetin significantly improved the energy profile of erythrocytes in rats with the overactive bladder syndrome...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905405/phosphodiesterase-inhibitors-potential-role-in-the-respiratory-distress-of-neonates
#12
REVIEW
Daniela Mokra, Juraj Mokry, Katarina Matasova
Phosphodiesterases (PDEs) are a superfamily of enzymes that catalyze the hydrolysis of phosphodiester bonds of 3',5' cyclic adenosine and guanosine monophosphate (cAMP and cGMP). PDEs control hydrolysis of cyclic nucleotides in many cells and tissues. Inhibition of PDEs by selective or nonselective PDE inhibitors represents an effective targeted strategy for the treatment of various diseases including respiratory disorders. Recent data have demonstrated that PDE inhibitors can also be of benefit in respiratory distress in neonates...
June 15, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29904907/systematic-review-and-guide-to-management-of-core-and-psychiatric-symptoms-in-youth-with-autism
#13
REVIEW
S H Ameis, C Kassee, P Corbett-Dick, L Cole, S Dadhwal, M-C Lai, J Veenstra-VanderWeele, C U Correll
OBJECTIVE: Evidence-based guidance of clinical decision-making for the management of Autism Spectrum Disorder (ASD) is lacking, particularly for co-occurring psychiatric symptoms. This review evaluates treatment evidence for six common symptom targets in children/adolescents with ASD and provides a resource to facilitate application of the evidence to clinical practice. METHOD: A systematic search identified randomized controlled trials (RCTs) and high-quality systematic reviews published between 2007 and 2016, focused on: social interaction/communication impairment, stereotypic/repetitive behaviours, irritability/agitation, attention-deficit/hyperactivity disorder symptoms, mood or anxiety symptoms, and sleep difficulties...
June 14, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29904814/dashboards-for-therapeutic-monoclonal-antibodies-learning-and-confirming
#14
Diane R Mould, Richard N Upton, Jessica Wojciechowski, Becky L Phan, Stacy Tse, Marla C Dubinsky
Inflammatory diseases (ID) are incurable, progressive diseases. Literature evidence cites increasing incidence of these diseases worldwide. When treatments with chemical immunosuppressive agents fail, patients are often treated with monoclonal antibodies (MAbs). However, MAb failure rates are generally high, with approximately half the patients being discontinued within 4 years, necessitating switching to another MAb. One potential cause of treatment failure is subtherapeutic exposure. Several studies demonstrated associations between trough MAb concentrations and clinical response, supporting the notion that improving drug exposure may result in improved outcomes...
June 14, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29904723/taurine-supplementation-abates-cirrhosis-associated-locomotor-dysfunction
#15
Reza Heidari, Akram Jamshidzadeh, Vahid Ghanbarinejad, Mohammad Mehdi Ommati, Hossein Niknahad
Aim of the study: Hepatic encephalopathy and hyperammonemia is a clinical complication associated with liver cirrhosis. The brain is the target organ for ammonia toxicity. Ammonia-induced brain injury is related to oxidative stress, locomotor activity dysfunction, and cognitive deficit, which could lead to permanent brain injury, coma and death if not appropriately managed. There is no promising pharmacological intervention against cirrhosis-associated brain injury. Taurine (TAU) is one of the most abundant amino acids in the human body...
June 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29904594/towards-precision-medicine-the-application-of-omics-technologies-in-asthma-management
#16
Chiara Scelfo, Carla Galeone, Francesca Bertolini, Marco Caminati, Patrizia Ruggiero, Nicola Facciolongo, Francesco Menzella
Asthma is a chronic obstructive respiratory disease characterised by bronchial inflammation. Its biological and clinical features have been widely explored and a number of pharmacological treatments are currently available. Currently several aspects of asthma pathophysiological background remain unclear, and this is crucial for the traditional asthma phenotype approach as well as for new endotype definition. In this scenario, the identification of new molecular and clinical biomarkers may be helpful in order to better understand the disease, define specific diagnostic tools and highlight relevant novel targets for pharmacology treatments...
2018: F1000Research
https://www.readbyqxmd.com/read/29904284/new-drug-developments-for-neuromuscular-blockade-and-reversal-gantacurium-cw002-cw011-and-calabadion
#17
REVIEW
Hans Donald de Boer, Ricardo Vieira Carlos
Purpose of Review: The purpose of this chapter is to provide a brief review of the literature on the recent developments in neuromuscular blockade and reversal agents. Recent Findings: Novel drug development resulted in pharmacological advancements in neuromuscular management and led to a new series of compounds, chlorofumarates, such as gantacurium, CW002, and CW011. These drugs have a fast onset and rapid to intermediate duration of action and can be rapidly reversed by l-cysteine adduction without side effects that are commonly observed with anticholinesterase reversal drugs...
2018: Current Anesthesiology Reports
https://www.readbyqxmd.com/read/29903879/adipocyte-derived-lipids-mediate-melanoma-progression-via-fatp-proteins
#18
Maomao Zhang, Julie S Di Martino, Robert L Bowman, Nathaniel R Campbell, Sanjeethan C Baksh, Theresa Simon-Vermot, Isabella S Kim, Pearce Haldeman, Chandrani Mondal, Vladimir Yong-Gonzalez, Mohsen Abu-Akeel, Taha Merghoub, Drew R Jones, Xiphias Ge Zhu, Arshi Arora, Charlotte E Ariyan, Kivanc Birsoy, Jedd D Wolchok, Katherine S Panageas, Travis J Hollmann, Jose Javier Bravo-Cordero, Richard M White
Advanced, metastatic melanomas frequently grow in subcutaneous tissues and portend a poor prognosis. Though subcutaneous tissues are largely composed of adipocytes, the mechanisms by which adipocytes influence melanoma are poorly understood. Using in vitro and in vivo models, we find that adipocytes increase proliferation and invasion of adjacent melanoma cells. Additionally, adipocytes directly transfer lipids to melanoma cells, which alters tumor cell metabolism. Adipocyte-derived lipids are transferred to melanoma cells through the FATP/SLC27A family of lipid transporters expressed on the tumor cell surface...
June 14, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29903607/improvement-of-physical-activity-in-chronic-obstructive-pulmonary-disease-by-pulmonary-rehabilitation-and-pharmacological-treatment
#19
REVIEW
Takanobu Shioya, Susumu Sato, Masahiro Iwakura, Hitomi Takahashi, Yoshino Terui, Sachiko Uemura, Masahiro Satake
Physical activity (PA) is defined as bodily movement produced by skeletal muscles with energy expenditure beyond resting levels. PA is closely related to reduced morbidity and mortality in chronic obstructive pulmonary disease (COPD). Self-report questionnaires are often subject to recall bias, correlating poorly with objectively qualified PA, and do not provide an accurate estimate of free-living energy expenditure. PA may be objectively evaluated by newly developed tri-axial accelerometers by quantifying steps or body movements over a period of time...
June 11, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29903580/an-emerging-circuit-pharmacology-of-gaba-a-receptors
#20
REVIEW
Elif Engin, Rebecca S Benham, Uwe Rudolph
In the past 20 years we have learned a great deal about GABAA receptor (GABAA R) subtypes, and which behaviors are regulated or which drug effects are mediated by each subtype. However, the question of where GABAA Rs involved in specific drug effects and behaviors are located in the brain remains largely unanswered. We review here recent studies taking a circuit pharmacology approach to investigate the functions of GABAA R subtypes in specific brain circuits controlling fear, anxiety, learning, memory, reward, addiction, and stress-related behaviors...
May 25, 2018: Trends in Pharmacological Sciences
keyword
keyword
44756
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"