Read by QxMD icon Read

Pharmaceutical chemistry

Ahmed Ma'mun, Mohamed K Abd El-Rahman, Mohamed Abd El-Kawy
In recent years, the whole field of ion-selective electrodes(ISEs) in pharmaceutical sciences has expanded far beyond its original roots. The diverse range of opportunities offered by ISEs was broadly used in a number of pharmaceutical applications, with topics presented ranging from bioanalysis of drugs and metabolites, to protein binding studies, green analytical chemistry, impurity profiling, and drug dissolution in biorelevant media. Inspired from these advances and with the aim of extending the functional capabilities of ISEs, the primary focus of the present paper is the utilization of ISE as a tool in personalized medicine...
February 7, 2018: Journal of Pharmaceutical and Biomedical Analysis
Pramod Singh Negi, Jitendra Singh, Geeta Joshi Nee Pant, Msm Rawat
Nitrogen containing five membered heterocyclics play vital role in pharmaceuticals as well as medicinal chemistry. Pyrazolines play a significant role among other heterocycles because of their therapeutic and pharmacological properties. 2-Pyrazolines displayed a wide variety of biological activities such as anticancer, antiepileptic, anti-aids, antimalarial, insecticidal and antitubercular etc. and they are used as pesticides, herbicides, fungicides and also used in agrochemical research and analytical chemistry...
March 13, 2018: Anti-cancer Agents in Medicinal Chemistry
Ludmila Martínková, Vladimír Křen
The aim of this study is to summarize the current progress in the design of biocatalytic processes applicable for the production of optically pure mandelic acids and their analogues. These compounds are used as building blocks for pharmaceutical chemistry and as chiral resolving agents. Their enzymatic syntheses mainly employed nitrile hydrolysis with nitrilases, ester hydrolysis, ammonolysis or esterification with lipases or esterases, and ketone reduction or alcohol oxidation with dehydrogenases. Each of these methods will be characterized in terms of its product concentrations, enantioselectivities, and the types of catalysts used...
March 10, 2018: Applied Microbiology and Biotechnology
Kodai Kato, Koji Hirano, Masahiro Miura
A CuCl/(R,R)-PTBP-BDPP-catalyzed regioselective and enantioselective aminoboration of simple and unactivated terminal alkenes with bis(pinacolato)diboron (pinB-Bpin) and hydroxylamines has been developed. The amino group and boryl group are incorporated at the internal position and terminal position, respectively, and the corresponding chiral beta-borylalkylamines are obtained with good to high enantiomeric ratios. The asymmetric copper catalysis allows for rapid and concise transformation of readily available olefinic feedstock-like materials into functionalized chiral alkylamines of high potential in medicinal and pharmaceutical chemistry...
March 7, 2018: Chemistry: a European Journal
Taishi Higashi, Daisuke Iohara, Keiichi Motoyama, Hidetoshi Arima
Supramolecular chemistry is an extremely useful and important domain for understanding pharmaceutical sciences because various physiological reactions and drug activities are based on supramolecular chemistry. However, it is not a major domain in the pharmaceutical field. In this review, we propose a new concept in pharmaceutical sciences termed "supramolecular pharmaceutical sciences," which combines pharmaceutical sciences and supramolecular chemistry. This concept could be useful for developing new ideas, methods, hypotheses, strategies, materials, and mechanisms in pharmaceutical sciences...
2018: Chemical & Pharmaceutical Bulletin
Samuel C Gill, Nathan M Lim, Patrick B Grinaway, Ariën S Rustenburg, Josh Fass, Gregory A Ross, John Damon Chodera, David L Mobley
Accurately predicting protein-ligand binding affinities and binding modes is a major goal in computational chemistry, but even the prediction of ligand binding modes in proteins poses major challenges. Here, we focus on solving the binding mode prediction problem for rigid fragments. That is, we focus on computing the dominant placement, conformation, and orientations of a relatively rigid, fragment-like ligand in a receptor, and the populations of the multiple binding modes which may be relevant. This problem is important in its own right, but is even more timely given the recent success of alchemical free energy calculations...
February 27, 2018: Journal of Physical Chemistry. B
A H Ide, J M F Nogueira
The present contribution aims to design new-generation bar adsorptive microextraction (BAμE) devices that promote an innovative and much better user-friendly analytical approach. The novel BAμE devices were lab-made prepared having smaller dimensions by using flexible nylon-based supports (7.5 × 1.0 mm) coated with convenient sorbents (≈ 0.5 mg). This novel advance allows effective microextraction and back-extraction ('only single liquid desorption step') stages as well as interfacing enhancement with the instrumental systems dedicated for routine analysis...
February 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
Harpreet Singh, Amrita Mishra, Arun Kumar Mishra
BACKGROUND: Since ancient times, species of Cleome genus are used to cure various ailments in human beings and same is stated in traditional treatises. Each part of the plant has its own significance, therefore, in background of its significance, upto date information in systematic manner is required. PURPOSE: The present review embarks on variety of naturally occurring compounds that have been isolated from various species of Cleome genus. The present study furnishes an overview of all naturally isolated compounds diterpenes, triterpenoids, trinorterpenoids, flavonol glycoside, coumarinolignoids, dipyridodiazepinone, essential oils, sesquiterpenes, flavonoids, carboxylic acid derivatives, lactone derivatives, sterols and pharmacological activities of various species of Cleome genus...
February 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yan-Ling Liu, Xiao-Mao Wang, Hong-Wei Yang, Yuefeng F Xie
Adsorption of trace organic compounds (TrOCs) onto the membrane materials has a great impact on their rejection by nanofiltration (NF) and reverse osmosis (RO) membranes. This study aimed to investigate the difference in adsorption of various pharmaceuticals (PhACs) onto different NF/RO membranes and to demonstrate the necessity of isolating the polyamide (PA) active layer from the polysulfone (PS) support layer for adsorption characterization and quantification. Both the isolated PA layers and the PA+PS layers of NF90 and ESPA1 membranes were used to conduct static adsorption tests...
February 16, 2018: Chemosphere
Tatiana Heid Furley, Julie Brodeur, Helena C Silva de Assis, Pedro Carriquiriborde, Katia R Chagas, Jone Corrales, Marina Denadai, Julio Fuchs, Renata Mascarenhas, Karina Sb Miglioranza, Diana Margarita Miguez Caramés, José Maria Navas, Danaythi Nugegoda, Estela Planes, Ignacio Alejandro Rodriguez-Jorquera, Martha Orozco-Medina, Alistair Ba Boxall, Murray A Rudd, Bryan W Brooks
The Global Horizon Scanning Project (GHSP) is an innovative initiative that aims to identify important global environmental quality research needs. Here we report 20 key research questions from Latin America (LA). Members of the Society of Environmental Toxicology and Chemistry (SETAC) LA and other scientists from LA were asked to submit research questions that would represent priority needs to address in the region. One hundred questions were received, then partitioned among categories, examined, and some rearranged during a workshop in Buenos Aires, Argentina...
February 22, 2018: Integrated Environmental Assessment and Management
Krishan Kumar, Arijit Ghosh
The clinical applications of PET imaging pharmaceuticals have increased tremendously over the last several years since the approval of 18F-FDG (18fluorine-fluorodeoxyglucose) by the Food and Drug Administration (FDA). Numerous 18F-labeled target-specific potential imaging pharmaceuticals, based on small and large molecules, have been evaluated in preclinical and clinical settings. 18F-labeling of organic moieties involves the introduction of the radioisotope by C-18F bond formation via a nucleophilic or an electrophilic substitution reaction...
February 21, 2018: Bioconjugate Chemistry
Rohan R Merchant, Jacob T Edwards, Tian Qin, Monika M Kruszyk, Cheng Bi, Guanda Che, Deng-Hui Bao, Wenhua Qiao, Lijie Sun, Michael R Collins, Olugbeminiyi O Fadeyi, Gary M Gallego, James J Mousseau, Philippe Nuhant, Phil S Baran
Cross-coupling chemistry is widely applied to carbon-carbon bond formation in the synthesis of medicines, agrochemicals, and other functional materials. Recently single-electron-induced variants of this reaction class have proven particularly useful in the formation of C(sp2 )-C(sp3 ) linkages, though certain compound classes have remained a challenge. Here we report the use of sulfones to activate the alkyl coupling partner in nickel-catalyzed radical cross-coupling with aryl zinc reagents. This method's tolerance of fluoroalkyl substituents proved particularly advantageous for the streamlined preparation of pharmaceutically-oriented fluorinated scaffolds that previously required multiple steps, toxic reagents, and non-modular retrosynthetic blueprints...
February 18, 2018: Science
Zachary G Jorgenson, Linnea M Thomas, Sarah M Elliott, Jenna E Cavallin, Eric C Randolph, Steven J Choy, David A Alvarez, Jo A Banda, Daniel J Gefell, Kathy E Lee, Edward T Furlong, Heiko L Schoenfuss
The Laurentian Great Lakes are a valuable natural resource that is affected by contaminants of emerging concern (CECs), including sex steroid hormones, personal care products, pharmaceuticals, industrial chemicals, and new generation pesticides. However, little is known about the fate and biological effects of CECs in tributaries to the Great Lakes. In the current study, 16 sites on three rivers in the Great Lakes basin (Fox, Cuyahoga, and Raquette Rivers) were assessed for CEC presence using polar organic chemical integrative samplers (POCIS) and grab water samplers...
February 14, 2018: Environmental Pollution
Yubin Li, Dianwen Ju
In the past decades, nanoparticles have been widely used in industry and pharmaceutical fields for drug delivery, anti-pathogen, and diagnostic imaging purposes because of their unique physicochemical characteristics such as special ultrastructure, dispersity, and effective cellular uptake properties. But the nanotoxicity has been raised over the extensive applications of nanoparticles. Researchers have elucidated series of mechanisms in nanoparticles-induced toxicity, including apoptosis, necrosis, oxidative stress, and autophagy...
2018: Advances in Experimental Medicine and Biology
Yi Zhong, Jieqiang Zhu, Zhenzhong Yang, Qing Shao, Xiaohui Fan, Yiyu Cheng
BACKGROUND: To ensure pharmaceutical quality, chemistry, manufacturing and control (CMC) research is essential. However, due to the inherent complexity of Chinese medicine (CM), CMC study of CM remains a great challenge for academia, industry, and regulatory agencies. Recently, quality-marker (Q-marker) was proposed to establish quality standards or quality analysis approaches of Chinese medicine, which sheds a light on Chinese medicine's CMC study. PURPOSE: Here manufacture processes of Panax Notoginseng Saponins (PNS) is taken as a case study and the present work is to establish a Q-marker based research strategy for CMC of Chinese medicine...
January 31, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Leonardo G Ferreira, Glaucius Oliva, Adriano D Andricopulo
Scientific and technological breakthroughs have compelled the current players in drug discovery to increasingly incorporate knowledge-based approaches. This evolving paradigm, which has its roots attached to the recent advances in medicinal chemistry, molecular and structural biology, has unprecedentedly demanded the development of up-to-date computational approaches, such as bio- and chemo-informatics. These tools have been pivotal to catalyzing the ever-increasing amount of data generated by the molecular sciences, and to converting the data into insightful guidelines for use in the research pipeline...
February 15, 2018: Anais da Academia Brasileira de Ciências
Mario Thevis, Oliver Krug, Hans Geyer, Katja Walpurgis, Norbert Baume, Andreas Thomas
Analytical chemistry represents a central aspect of doping controls. Routine sports drug testing approaches are primarily designed to address the question whether a prohibited substance is present in a doping control sample and whether prohibited methods (for example, blood transfusion or sample manipulation) have been conducted by an athlete. As some athletes have availed themselves of the substantial breadth of research and development in the pharmaceutical arena, proactive and preventive measures are required such as the early implementation of new drug candidates and corresponding metabolites into routine doping control assays, even though these drug candidates are to date not approved for human use...
February 14, 2018: Analytical and Bioanalytical Chemistry
Vincent Desfontaine, Francesca Capetti, Raul Nicoli, Tiia Kuuranne, Jean-Luc Veuthey, Davy Guillarme
Matrix effects (ME) is acknowledged as being one of the major drawbacks of quantitative bioanalytical methods, involving the use of liquid chromatography coupled to mass spectrometry (LC-MS). In the present study, the incidence of ME in SFC-MS/MS and LC-MS/MS in the positive mode electrospray ionization (ESI+) was systematically compared for the analysis of urine and plasma samples using two representative sets of 40 doping agents and 38 pharmaceutical compounds, respectively. Three different SFC stationary phase chemistries were employed, to highlight the importance of the column in terms of selectivity...
February 7, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Yahya E Jad, Santosh Kumar Gudimella, Thavendran Govender, Beatriz G de la Torre, Fernando Albericio
The synthesis of pyrroles has received considerable attention because of their biological and pharmaceutical activities. Herein we describe a solid-phase multicomponent reaction that utilizes Lys as a N donor, β-nitrostyrenes, 1,3-dicarbonyl compounds, and FeCl3 as an easily accessible catalyst under microwave irradiation affords the subsequent pyrrole derivatives in high conversions. The strategy combines three of the most powerful tools in modern synthetic chemistry: the solid-phase mode, the microwave activation and a multicomponent reaction...
February 14, 2018: ACS Combinatorial Science
Denial Mahata, Ahindra Nag, Golok B Nando, Santi M Mandal, Octavio L Franco
Green chemistry polymers from renewable resources have recently received much more attention from pharmaceutical researchers. However, the appropriate application of a polymer depends on its chemical nature, biocompatibility and microstructure. Here, tannin polyphenols from the common beverage, tea, are used to develop a novel self-assembled porous capsule as a microstructure of hydrogel for versatile biological applications, such as drug delivery, antioxidant and wound healing activity. Hydrogel has been successfully used for the delivery of both anticancer and antimicrobial drugs...
April 1, 2018: Journal of Nanoscience and Nanotechnology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"