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https://www.readbyqxmd.com/read/28343167/the-unappreciated-roles-of-the-cholecystokinin-receptor-cck-1-in-brain-functioning
#1
Santiago Ballaz
The CCK(1) receptor is a G-protein-coupled receptor activated by the sulfated forms of cholecystokinin (CCK), a gastrin-like peptide released in the gastrointestinal tract and mammal brain. A substantial body of research supports the hypothesis that CCK(1)r stimulates gallbladder contraction and pancreatic secretion in the gut, as well as satiety in brain. However, this receptor may also fulfill relevant roles in behavior, thanks to its widespread distribution in the brain. The strategic location of CCK(1)r in mesolimbic structures and specific hypothalamic and brainstem nuclei lead to complex interactions with neurotransmitters like dopamine, serotonin, and glutamate, as well as hypothalamic hormones and neuropeptides...
March 25, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28343063/motives-for-illicit-prescription-drug-use-among-university-students-a-systematic-review-and-meta-analysis
#2
REVIEW
Trevor Bennett, Katy Holloway
BACKGROUND: There is a growing body of research on the motives for prescription drug misuse (PDM) among university students. However, the overall findings of this research are hard to decipher. Studies use different methods, they examine different drug types, the motives are phrased in various ways, and the results differ widely. In order to make sense of this body of knowledge, it is necessary to synthesise the results across studies and draw out conclusions. METHODS: The research comprises a systematic review and meta-analysis of studies on the motives of university students for illicit use of four different types of prescription medication (stimulants, analgesics, tranquillisers and sedatives)...
March 23, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28342943/would-i-take-antipsychotics-if-i-had-psychotic-symptoms-examining-determinants-of-the-decision-to-take-antipsychotics
#3
Fabrice Berna, Anja S Göritz, Pierre-Michel Llorca, Pierre Vidailhet, Guillaume Fond, Steffen Moritz
Poor adherence to treatment in schizophrenia is mainly associated to patients-related factors. However, social negative representations of schizophrenia and its treatment may also contribute to patients' decision to take or not to take antipsychotics. A web-based study on 1807 participants was conducted during which participants imagined that they had a particular chronic illness based on clinical vignettes (mental illnesses: schizophrenia, depression; somatic illnesses: multiple sclerosis, rheumatoid arthritis)...
March 22, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28340446/mental-health-and-behavioral-weight-loss-24-month-outcomes-in-veterans
#4
Carol A Janney, Robin M Masheb, Lesley D Lutes, Robert G Holleman, Hyungjin Myra Kim, Leah R Gillon, Laura J Damschroder, Caroline R Richardson
BACKGROUND: Individuals with mental health (MH) disorders have an increased risk of being overweight/obese; however research on behavioral weight loss interventions has been limited. A priori hypothesis was that Veterans with serious mental illness (SMI) and/or affective disorders (AD) would lose significantly less weight and have a different pattern of weight loss than Veterans without these diagnoses. METHODS: Secondary data analysis of ASPIRE-VA study, three-arm randomized, effectiveness weight loss trial among Veterans (n=409) categorized by MH diagnoses: 1) SMI, 2) AD without SMI, or 3) No SMI/No AD...
March 11, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28338353/the-burden-of-familial-chylomicronemia-syndrome-interim-results-from-the-in-focus-study
#5
Michael Davidson, Michael Stevenson, Andrew Hsieh, Zahid Ahmad, Caroline Crowson, Joseph L Witztum
BACKGROUND: Familial Chylomicronemia Syndrome (FCS) is a rare genetic disorder that is caused by a decrease or an absence of lipoprotein lipase activity. FCS is characterized by marked accumulation of chylomicrons and extreme hypertriglyceridemia, which have major effects on both physical and mental health. To date, there have been no systematic efforts to characterize the impact of chylomicronemia on FCS patients' lives. In particular, the impact of FCS on the burden of illness (BoI) and quality of life (QoL) has not been fully described in the literature...
March 24, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28337924/making-sense-of-the-public-stigma-of-suicide
#6
Patrick W Corrigan, Lindsay Sheehan, Maya A Al-Khouja
BACKGROUND: Research suggests that stigma is a barrier to care for individuals who have attempted suicide. While extensive work has examined the stigma of mental illness, less research has focused on the public stigma of suicide. Existing measures of suicide stigma have lacked a conceptual foundation or have failed to include the perspectives of suicide stakeholders. AIMS: This research draws on previous qualitative research with suicide stakeholders to create a measure of public suicide stigma...
March 24, 2017: Crisis
https://www.readbyqxmd.com/read/28337511/-dementia-in-the-focus-of-health-research-a%C3%A2-comparative-analysis-of-current-ageing-studies
#7
Kristin Illiger, Ulla Walter, Frauke Koppelin
Health research on an increasingly aging population calls for careful consideration of aging-associated phenomena, such as dementia. Accounting for such diseases is a necessary step for gaining a view of health in the elderly. It is moreover imperative to gather data on subjects' mental limitations in surveys to better evaluate the validity of answers disclosed by elderly participants. This article discusses the availability of data on individuals suffering from dementia in national studies on aging. It centers on the question of how surveys respond to the challenge of diagnosing dementia...
March 23, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28336493/the-central-mechanism-of-risperidone-induced-hyperprolactinemia
#8
Wei-Wei Sun, Lin-Yu Li, Xu-Feng Huang, Yan-Chuan Shi, He-Qin Yang, Zhi-Yuan Song, Shu Lin
Risperidone is known to increase prolactin secretion in treating mental illness patients. This side-effect is thought to be mediated via central signaling pathway. However, the exact pathway involved between risperidone and hyperprolactinemia are still unknown. Therefore, we have treated mice with risperidone and investigate the central mechanisms. The present study showed that in risperidone treated group, the level of the serum prolactin significantly increased, which was consistent with increased positive prolactin staining in pituitary gland...
March 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28334933/disrupted-in-schizophrenia-1is-essential-for-normal-hypothalamic-pituitary-interrenal-hpi-axis-function
#9
Helen Eachus, Charlotte Bright, Vincent T Cunliffe, Marysia Placzek, Jonathan D Wood, Penelope J Watt
Psychiatric disorders arise due to an interplay of genetic and environmental factors, including stress. Studies in rodents have shown that mutants for Disrupted-In-Schizophrenia-1 (DISC1), a well-accepted genetic risk factor for mental illness, display abnormal behaviours in response to stress, but the mechanisms through which DISC1 affects stress responses remain poorly understood. Using two lines of zebrafish homozygous mutant for disc1, we investigated behaviour and functioning of the hypothalamic-pituitary-interrenal (HPI) axis, the fish equivalent of the hypothalamic-pituitary-adrenal (HPA) axis...
March 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28334470/yoga-breast-cancer-related-lymphoedema-and-wellbeing-a-descriptive-report-of-women-s-participation-in-a-clinical-trial
#10
Annette Loudon, Tony Barnett, Andrew Williams
AIM: To describe the experiences of women taking part in a yoga intervention trial for breast cancer-related lymphoedema. BACKGROUND: Around 20% of women will experience lymphoedema as a consequence of treatment for breast cancer. Specialist lymphoedema clearing, along with self-management, remains the mainstay of therapy. Yoga, an increasingly popular complementary therapeutic practice, may provide another tool to augment self-management. DESIGN: A qualitative, descriptive design...
March 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28333489/occupations-and-the-prevalence-of-major-depressive-episode-in-the-national-survey-on-drug-use-and-health
#11
Albert Woodward, Rachel Lipari, William Eaton
OBJECTIVE: This study explores the relationship of occupations to major depressive episode (MDE). METHOD: National Survey on Drug Use and Health (NSDUH) data from the civilian noninstitutionalized United States population are analyzed regarding mental illnesses, employment, and specific occupations and industries. This analysis uses combined 2005 to 2014 NSDUH data, comprising a sample of 433,000 adults aged 18 to 64 years old, of whom 22,700 were both employed and had experienced an MDE in the past year...
March 23, 2017: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/28333488/the-hierarchical-taxonomy-of-psychopathology-hitop-a-dimensional-alternative-to-traditional-nosologies
#12
Roman Kotov, Robert F Krueger, David Watson, Thomas M Achenbach, Robert R Althoff, R Michael Bagby, Timothy A Brown, William T Carpenter, Avshalom Caspi, Lee Anna Clark, Nicholas R Eaton, Miriam K Forbes, Kelsie T Forbush, David Goldberg, Deborah Hasin, Steven E Hyman, Masha Y Ivanova, Donald R Lynam, Kristian Markon, Joshua D Miller, Terrie E Moffitt, Leslie C Morey, Stephanie N Mullins-Sweatt, Johan Ormel, Christopher J Patrick, Darrel A Regier, Leslie Rescorla, Camilo J Ruggero, Douglas B Samuel, Martin Sellbom, Leonard J Simms, Andrew E Skodol, Tim Slade, Susan C South, Jennifer L Tackett, Irwin D Waldman, Monika A Waszczuk, Thomas A Widiger, Aidan G C Wright, Mark Zimmerman
The reliability and validity of traditional taxonomies are limited by arbitrary boundaries between psychopathology and normality, often unclear boundaries between disorders, frequent disorder co-occurrence, heterogeneity within disorders, and diagnostic instability. These taxonomies went beyond evidence available on the structure of psychopathology and were shaped by a variety of other considerations, which may explain the aforementioned shortcomings. The Hierarchical Taxonomy Of Psychopathology (HiTOP) model has emerged as a research effort to address these problems...
March 23, 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28332928/attitudinal-changes-toward-homosexuality-during-the-past-two-decades-1994-2014-in-korea
#13
Gahyun Youn
This study was conducted to examine recent Korean perspectives on homosexuality by comparing attitudes toward mental illness, crime, friendship, and civil rights related to homosexual people in 1994, 1999, 2004, 2009, and 2014. The respondents were 3,299 Korean men and women between 18 and 59 years of age, and the data were collected across five years. The major findings were that there has been greater acceptance of homosexuality and civil rights for homosexuals during the past two decades, but the changes have been slow; Korean homosexuals remain subjects of social stigma and discrimination primarily due to increased Christian activism...
March 23, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28332861/treatment-of-nightmares-in-psychiatric-inpatients-with-imagery-rehearsal-therapy-an-open-trial-and-case-series
#14
Thomas E Ellis, Katrina A Rufino, Michael R Nadorff
OBJECTIVES: This study sought to assess the utility of Imagery Rehearsal Therapy (IRT) for nightmares in an inpatient psychiatric setting. Although IRT enjoys a substantial evidence base for efficacy in various populations, data with psychiatric inpatients are lacking. PARTICIPANTS: Participants were 20 adult psychiatric inpatients (11 male, 9 female; mean age=43.4), in an extended stay psychiatric inpatient facility. All participants were diagnosed with multiple, treatment resistant, comorbid conditions, including mood disorders, anxiety disorders, personality disorders, and substance-related disorders...
March 23, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28332124/use-of-physical-restraints-among-patients-with-bipolar-disorder-in-ethiopian-mental-specialized-hospital-outpatient-department-cross-sectional-study
#15
Habte Belete
BACKGROUND: Even though United Nation announced that all persons with a mental illness shall be treated with humanity and respect for the inherent dignity of the human being, up to now, the use of coercion (physical restrain) is still considered as unavoidable in managing abnormal behavior of psychiatric patients. But, there is no information regarding the magnitude and contributing factors of physical restrain among bipolar patients in low-income countries like Ethiopia. METHODS: A cross-sectional study was conducted at Amanuel Mental Specialized Hospital from May 1 to June 1, 2015 among 400 participants who were selected by systematic random sampling technique...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28332099/integrated-multisystem-analysis-in-a-mental-health-and-criminal-justice-ecosystem
#16
Erin Falconer, Tal El-Hay, Dimitris Alevras, John P Docherty, Chen Yanover, Alan Kalton, Yaara Goldschmidt, Michal Rosen-Zvi
BACKGROUND: Patients with a serious mental illness often receive care that is fragmented due to reduced availability of or access to resources, and inadequate, discontinuous, and uncoordinated care across health, social services, and criminal justice organizations. This article describes the creation of a multisystem analysis that derives insights from an integrated dataset including patient access to case management services, medical services, and interactions with the criminal justice system...
December 2017: Health & Justice
https://www.readbyqxmd.com/read/28332036/the-committed-intimate-partnerships-of-incarcerated-african-american-men-implications-for-sexual-hiv-transmission-risk-and-prevention-opportunities
#17
Maria R Khan, Nabila El-Bassel, Carol E Golin, Joy D Scheidell, Adaora A Adimora, Ashley M Coatsworth, Hui Hu, Selena Judon-Monk, Katie P Medina, David A Wohl
Incarceration is thought to influence HIV transmission by disrupting partnerships that provide support and protect against sex risk-taking. Current correctional facility-based family-strengthening programs focus on marital partnerships, a minority of inmates' partnerships. Research on the sex partnerships of incarcerated African-American men and the types of partnerships most likely to protect against HIV-related sex risk is limited. Improved understanding can inform expansion of correctional facility-based family-strengthening programs to a greater proportion of protective partnerships and HIV risk reduction programs to partnerships vulnerable to sex risk...
March 22, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28332002/a-systematic-review-of-research-on-psychiatric-mother-baby-units
#18
REVIEW
Kathleen Connellan, Clare Bartholomaeus, Clemence Due, Damien W Riggs
Psychiatric mother-baby units (MBUs) are currently viewed as best practice, particularly in the UK, Australia and France, for improving outcomes for mothers and babies when the former are experiencing severe forms of mental illness. A growing number of publications have examined MBUs, but to date, there has not been a comprehensive review of these studies. As such, the systematic review reported in this paper sought to address this gap. A systematic search was conducted for peer-reviewed research and grey literature published in English between 2000 and 2015...
March 22, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28331751/subcutaneous-oleomas-following-sunflower-oil-injection-a-novel-case-and-review-of-literature
#19
Özgür Sarıca, Arda Kayhan, Hüseyin Cengiz Demirkürek, Ayşenur Akyıldız İğdem
Liquid foreign material injection has been used as an early medical intervention since the end of nineteenth century for the augmentation of body shape. Nowadays, these types of procedures have been abandoned by health professionals due to late onset of serious complications. However, it is still misused by some subcultures such as bodybuilders, passive homosexuals, transsexuals, and patients with mental illness. This article discusses a male patient who injected himself with a large amount of sunflower oil, which became complicated by an inflammatory response-abscess formation and sclerosing lipogranuloma of breasts...
July 2016: J Breast Health (2013)
https://www.readbyqxmd.com/read/28331328/preliminary-evaluation-of-a-formulation-driven-cognitive-behavioral-guided-self-help-fcbt-gsh-for-crisis-and-transitional-case-management-clients
#20
Farooq Naeem, Rupinder K Johal, Claire Mckenna, Olivia Calancie, Tariq Munshi, Tariq Hassan, Amina Nasar, Muhammad Ayub
BACKGROUND: Cognitive behavioral therapy (CBT) is found to be effective for common mental disorders and has been delivered in self-help and guided self-help formats. Crisis and transitional case management (TCM) services play a vital role in managing clients in acute mental health crises. It is, therefore, an appropriate setting to try CBT in guided self-help format. METHODS: This was a preliminary evaluation of a formulation-driven cognitive behavioral guided self-help...
2017: Neuropsychiatric Disease and Treatment
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