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Out-of-hospital cardiac arrest and genetic analysys

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June 2016: Annals of Intensive Care
B R Scholefield, F Gao, H P Duncan, R C Tasker, R C Parslow, E S Draper, P McShane, P Davies, K P Morris
AIMS: To estimate the prevalence of children admitted after out-of-hospital cardiac arrest (OHCA) to UK and Republic of Ireland (RoI) Paediatric Intensive Care Units (PICUs) and factors associated with mortality to inform future clinical trial feasibility. METHOD: Observational study using a prospectively collected dataset of the Paediatric Intensive Care Audit Network (PICANet) of 33 UK and RoI PICUs (January 2003 to June 2010). Cases (0 to <16 years), with documented OHCA surviving to PICU admission and requiring mechanical ventilation were included...
December 2015: Resuscitation
Thomas W Lindner, Charles D Deakin, Hildegunn Aarsetøy, Sten Rubertsson, Jon-Kenneth Heltne, Eldar Søreide
OBJECTIVE: In the last few years the genetic influence on health and disease outcome has become more apparent. The ACE genotype appears to play a significant role in the pathophysiology of several disease processes. This pilot study aims at showing the feasibility to examine the genetic influence of the ACE genotype on return of spontaneous circulation (ROSC) in out-of-hospital cardiac arrest (OHCA). METHODS: We performed a prospective observational study of all OHCAs of presumed cardiac origin in a well-defined population...
2014: Open Heart
Roos F Marsman, Julien Barc, Leander Beekman, Marielle Alders, Dennis Dooijes, Arthur van den Wijngaard, Ilham Ratbi, Abdelaziz Sefiani, Zahurul A Bhuiyan, Arthur A M Wilde, Connie R Bezzina
OBJECTIVES: This study aimed to identify the genetic defect in a family with idiopathic ventricular fibrillation (IVF) manifesting in childhood and adolescence. BACKGROUND: Although sudden cardiac death in the young is rare, it frequently presents as the first clinical manifestation of an underlying inherited arrhythmia syndrome. Gene discovery for IVF is important as it enables the identification of individuals at risk, because except for arrhythmia, IVF does not manifest with identifiable clinical abnormalities...
January 28, 2014: Journal of the American College of Cardiology
Jodie Ingles, Tanya Sarina, Laura Yeates, Lauren Hunt, Ivan Macciocca, Louise McCormack, Ingrid Winship, Julie McGaughran, John Atherton, Christopher Semsarian
PURPOSE: Genetic testing for hypertrophic cardiomyopathy has been commercially available for almost a decade; however, low mutation detection rate and cost have hindered uptake. This study sought to identify clinical variables that can predict probands with hypertrophic cardiomyopathy in whom a pathogenic mutation will be identified. METHODS: Probands attending specialized cardiac genetic clinics across Australia over a 10-year period (2002-2011), who met clinical diagnostic criteria for hypertrophic cardiomyopathy and who underwent genetic testing for hypertrophic cardiomyopathy were included...
December 2013: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Petri Tyynelä, Sirkka Goebeler, Erkki Ilveskoski, Jussi Mikkelsson, Markus Perola, Terho Lehtimäki, Pekka J Karhunen
BACKGROUND: Mortality from coronary heart disease (CHD) has been constantly higher in eastern late settlement regions compared to western early settlements in Finland, unrelated to classical risk factors. In line with this, eastern birthplace was an age-dependent predictor of severe coronary atherosclerosis and pre-hospital sudden coronary death among male residents of Helsinki. We investigated a possible interaction of apolipoprotein E (APOE) gene with birthplace on the risk of myocardial infarction (MI) and coronary atherosclerosis...
May 2013: Annals of Medicine
Catherine O Johnson, Rozenn N Lemaitre, Carol E Fahrenbruch, Stephanie Hesselson, Nona Sotoodehnia, Barbara McKnight, Kenneth M Rice, Pui-Yan Kwok, David S Siscovick, Thomas D Rea
BACKGROUND: Fatty acids provide energy and structural substrates for the heart and brain and may influence resuscitation from sudden cardiac arrest (SCA). We investigated whether genetic variation in fatty acid metabolism pathways was associated with SCA survival. METHODS AND RESULTS: Subjects (mean age, 67 years; 80% male, white) were out-of-hospital SCA patients found in ventricular fibrillation in King County, WA. We compared subjects who survived to hospital admission (n=664) with those who did not (n=689), and subjects who survived to hospital discharge (n=334) with those who did not (n=1019)...
August 1, 2012: Circulation. Cardiovascular Genetics
Jitendra Vohra, Jonathan Skinner, Christopher Semsarian
Nearly 30% of young sudden deaths have negative autopsies and these sudden unexplained deaths (SUDs) are presumed to be due to heritable cardiac arrhythmias attributed to cardiac ion channel disorders. Comprehensive cardiac and genetic testing of families of SUD is helpful in the detection of inherited cardiac genetic conditions. It frequently provides a clue to the cause of death in SUD victims and allows early diagnosis and opportunities to prevent SUD in other family members. Out of Hospital Cardiac Arrest (OHCA) victims and their families also require similar assessment, although the role of genetic testing in this group should be reserved to patients where a clinical diagnosis is established...
December 2011: Heart, Lung & Circulation
Avishag Laish-Farkash, Michael Glikson, Dovrat Brass, Dina Marek-Yagel, Elon Pras, Nathan Dascal, Charles Antzelevitch, Eyal Nof, Haya Reznik, Michael Eldar, David Luria
OBJECTIVES: to conduct a clinical, genetic, and functional analysis of 3 unrelated families with familial sinus bradycardia (FSB). BACKGROUND: mutations in the hyperpolarization-activated nucleotide-gated channel (HCN4) are known to be associated with FSB. METHODS AND RESULTS: three males of Moroccan Jewish descent were hospitalized: 1 survived an out-of-hospital cardiac arrest and 2 presented with weakness and presyncopal events. All 3 had significant sinus bradycardia, also found in other first-degree relatives, with a segregation suggesting autosomal-dominant inheritance...
December 2010: Journal of Cardiovascular Electrophysiology
Haitham Hreybe, Ish Singla, Eathar Razak, Samir Saba
BACKGROUND: Cardiac arrest (CA) concurrent with acute myocardial infarction (AMI) claims the life of many patients with coronary artery disease (CAD). In this study, we investigated the predictors of CA during AMI. METHOD: Patients admitted with CA concurrent with AMI (n = 31) were matched by age, gender, race, and left ventricular ejection fraction (LVEF) to patients with AMI but no CA (n = 70). All patients underwent coronary angiography. Binary logistic regression was used to identify independent predictors of CA during AMI...
October 2007: Pacing and Clinical Electrophysiology: PACE
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