Yanjun Liu, Jui Tu, Linsen Shi, Zhipeng Fang, Mingjie Fan, Jianying Zhang, Lili Ding, Yiqiang Chen, Yangmeng Wang, Eryun Zhang, Senlin Xu, Nisha Sharma, John D Gillece, Lauren J Reining, Lihua Jin, Wendong Huang
BACKGROUND AIMS: Although the benefits of vertical sleeve gastrectomy surgery (VSG) are well known, the molecular mechanisms by which VSG alleviates obesity and its complications remain unclear. We aim to determine a role of CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) in mediating the metabolic benefits of VSG. APPROACH RESULTS: We found that expression of CYP8B1, a key enzyme in controlling the 12α-hydroxylated (12α-OH) bile acid (BA) to non-12α-OH BA ratio, was strongly downregulated after VSG...
October 11, 2023: Hepatology: Official Journal of the American Association for the Study of Liver Diseases