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Renal transplant obesity

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https://www.readbyqxmd.com/read/29725634/bowman-capsule-volume-and-related-factors-in-adults-with-normal-renal-function
#1
Takaya Sasaki, Nobuo Tsuboi, Kotaro Haruhara, Yusuke Okabayashi, Go Kanzaki, Kentaro Koike, Akimitsu Kobayashi, Izumi Yamamoto, Makoto Ogura, Takashi Yokoo
Introduction: Alterations in glomerular filtration can considerably influence the dynamics and functions of the Bowman capsule. Despite the potentially important role in maintaining normal renal functions, few studies have focused on Bowman capsule volume in normal human kidneys. Methods: We analyzed specimens from biopsies performed 1 hour after kidney transplantation from living donors without apparent renal disease. The measurements of all cross-sectional areas of the Bowman capsules and glomerular capillaries were used to estimate the mean Bowman capsule volume (BV) and glomerular capillary volume (GV) in each subject...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29709681/class-iii-obesity-is-a-risk-factor-for-the-development-of-acute-on-chronic-liver-failure-in-patients-with-decompensated-cirrhosis
#2
Vinay Sundaram, Rajiv Jalan, Joseph C Ahn, Michael R Charlton, David S Goldberg, Constantine J Karvellas, Mazen Noureddin, Robert Wong
BACKGROUND AND AIMS: Acute on chronic liver failure (ACLF) is a syndrome of systemic inflammation and organ failures. Obesity, also characterized by chronic inflammation, is a risk factor among patients with cirrhosis for decompensation, infection, and mortality. Our aim was to test the hypothesis that obesity predisposes to ACLF development in patients with decompensated cirrhosis. METHODS: We examined the United Network for Organ Sharing (UNOS) database, from 2005-2016, characterizing patients at wait-listing as non-obese (BMI < 30), obese class I-II (BMI 30-39...
April 27, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29707620/outcome-of-patients-with-small-vessel-vasculitis-after-renal-transplantation-national-database-analysis
#3
Amr El-Husseini, Sherif Saleh, Omer Hamad, Xiaonan Mei, Ana Lia Castellanos, Daniel L Davenport, Roberto Gedaly, B Peter Sawaya
Background: Small vessel vasculitis commonly affects the kidney and can progress to end-stage renal disease. The goal of this study is to compare outcomes of patients who received a renal transplant as a result of small vessel vasculitis (group A) with those who received kidney transplants because of other causes (group B). Methods: This is a retrospective analysis of United Network for Organ Sharing registry data for adult primary kidney transplants from January 2000 to December 2014...
March 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29680422/effect-of-kidney-transplantation-on-sleep-disordered-breathing-in-patients-with-end-stage-renal-disease-a-polysomnographic-study
#4
Sanjiv Mahajan, Kartik Gupta, Sanjeev Sinha, Atul Malhotra, Sandeep Mahajan
BACKGROUND: Sleep-disordered breathing (SDB) is common in patients with end-stage renal disease (ESRD). SDB is associated with comorbidities such as hypertension, diabetes mellitus, and obesity, interplaying with metabolic derangements in the form of uremia, acidosis, and hypervolemia. Renal transplant has been observed to correct most of these metabolic derangements and to control progression of comorbidities. While SDB is highly prevalent among patients in the pretransplant stage, it remains to be seen whether the beneficial aspects of transplant are extended to improvement in SDB in patients with ESRD...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29619909/where-to-draw-the-line-in-surgical-obesity-for-renal-transplant-recipients-an-outcome-analysis-based-on-body-mass-index
#5
Alexander Mehta, Abbas Ghazanfar, Alison Marriott, Mohamed Morsy
OBJECTIVES: Renal transplant is the criterion standard treatment for patients with end-stage renal disease. Because obesity rates are increasing in the global population, international standards on renal transplant in obese patients remain a gray area. The aim of this study was to determine whether renal transplant remains the treatment of choice in an obese patient with end-stage renal disease. MATERIALS AND METHODS: We performed a retrospective analysis on all patients who underwent renal transplant in our transplant unit between January 2008 and December 2013...
April 4, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29579850/reasons-for-noninclusion-on-the-kidney-transplant-waiting-list-analysis-in-a-set-of-hemodialysis-centers
#6
N G Toapanta-Gaibor, M Suñer-Poblet, M Cintra-Cabrera, M Á Pérez-Valdivia, A Suárez-Benjumea, F M Gonzalez-Roncero, G Bernal-Blanco, J L Rocha-Castilla, M Á Gentil-Govantes
INTRODUCTION: End-stage renal disease patients' access to the renal transplant (RT) waiting list (WL) depends on general criteria and their specific application in the different treatment units. METHODS: Study in nonhospital hemodialysis centers (n = 9), dependent on an adult RT center. Cases included 228 patients considered to have nonactive status on the WL due to incomplete immunologic data (no blood group or HLA typing) or temporary contraindication from an incomplete pretransplant study (nonimmunologic) or comorbidity...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29574612/effect-of-bmi-on-allograft-function-and-survival-in-pediatric-renal-transplant-recipients
#7
Erica Winnicki, Madan Dharmar, Daniel J Tancredi, Stephanie Nguyen, Lavjay Butani
OBJECTIVE: To determine whether pre-transplant body mass index (BMI) affects renal allograft function and survival in pediatric renal transplant recipients. STUDY DESIGN: This is a retrospective cohort study using the Organ Procurement and Transplantation Network data from 2000 to 2013 to compare time to total allograft loss (allograft failure or death), prevalence of delayed graft function, prevalence of acute rejection, and estimated glomerular filtration rate (eGFR) post-transplant in pediatric renal transplant recipients categorized by BMI z-score...
March 25, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29536031/one-year-outcomes-of-a-cohort-of-renal-transplant-patients-related-to-bmi-in-a-steroid-sparing-regimen
#8
Maria Irene Bellini, Kostas Koutroutsos, Jack Galliford, Paul E Herbert
Background: The prevalence of overweight and obese kidney transplant recipients (KTR) has risen in parallel to the obesity epidemic that has affected the general population over the last two decades. At present, there is an ongoing debate regarding the suitability for transplantation of obese patients. Methods: Data were prospectively collected on consecutive single organ KTR transplanted between January 2014 and March 2016. The patients were stratified according to their body mass index (BMI) using the World Health Organization classification...
December 2017: Transplantation Direct
https://www.readbyqxmd.com/read/29529604/influence-of-sprint-study-type-automated-office-blood-pressure-measurements-on-hypertension-diagnosis-in-kidney-transplant-patients
#9
Akanksha Bhatnagar, Ulrich Pein, Silke Markau, Karl Weigand, Paolo Fornara, Matthias Girndt, Eric Seibert
BACKGROUND/AIMS: We compare conventional office blood pressure measurements with automated SPRINT-study type readings in kidney transplant recipients in order to determine the impact of the white coat effect in a prospective observational study. METHODS: Adult patients with a functional renal transplant not dependent on dialysis were eligible. Readings were taken in the office in presence of the physician with an oscillometric method. Afterwards, readings were repeated with the patients resting alone in a quiet examination room with an automated blood pressure monitor...
March 6, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29527994/obesity-in-the-kidney-transplant-process
#10
Damla Ateş, Fatma Cebeci
Obesity, which has become an increasing problem worldwide, poses a risk for kidney transplant recipients both before and after surgery. In this literature review, we studied the effects of obesity before and after kidney transplant. There are numerous studies and different opinions on the effects of obesity on graft function before and after transplant. Obesity prolongs surgery time and the ischemic process. A large cohort study of 11 836 recipients noted a close association between body mass index and delayed renal transplant and delayed graft function...
March 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29524184/development-of-de-novo-diabetes-in-long-term-follow-up-after-bariatric-surgery
#11
Zubaidah Nor Hanipah, Suriya Punchai, Stacy A Brethauer, Philip R Schauer, Ali Aminian
INTRODUCTION: While bariatric surgery leads to significant prevention and improvement of type 2 diabetes, patients may rarely develop diabetes after bariatric surgery. The aim of this study was to determine the incidence and the characteristic of new-onset diabetes after bariatric surgery over a 17-year period at our institution. METHODS: Non-diabetic patients who underwent bariatric surgery at a single academic center (1997-2013) and had a postoperative glycated hemoglobin (HbA1c) ≥ 6...
March 9, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29519780/robotic-versus-open-renal-transplantation-in-obese-patients-protocol-for-a-cost-benefit-markov-model-analysis
#12
Michele Molinari, Chethan Puttarajappa, Martin Wijkstrom, Armando Ganoza, Roberto Lopez, Amit Tevar
BACKGROUND: Recent studies have reported a significant decrease in wound problems and hospital stay in obese patients undergoing renal transplantation by robotic-assisted minimally invasive techniques with no difference in graft function. OBJECTIVE: Due to the lack of cost-benefit studies on the use of robotic-assisted renal transplantation versus open surgical procedure, the primary aim of our study is to develop a Markov model to analyze the cost-benefit of robotic surgery versus open traditional surgery in obese patients in need of a renal transplant...
March 8, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29499059/progranulin-serum-levels-in-human-kidney-transplant-recipients-a-longitudinal-study
#13
Bruna Bellincanta Nicoletto, Elis Forcellini Pedrollo, Larissa Salomoni Carpes, Natália Gomes Coloretti, Thaiana Cirino Krolikowski, Gabriela Corrêa Souza, Luiz Felipe Santos Gonçalves, Roberto Ceratti Manfro, Luis Henrique Canani
BACKGROUND: The adipokine progranulin has metabolic proprieties, playing a role in obesity and insulin resistance. Its levels seems to be dependent of renal function, since higher progranulin concentration is observed in patients with end-stage kidney disease. However, the effect of kidney transplantation on progranulin remains unknown. OBJECTIVE: To assess the serum progranulin levels in kidney transplant recipients before and after kidney transplantation. METHODS: Forty-six prospective kidney transplant recipients were included in this longitudinal study...
2018: PloS One
https://www.readbyqxmd.com/read/29493818/cytomegalovirus-reactivation-in-liver-transplant-recipients-due-to-hepatitis-c-cirrhosis-is-associated-with-higher-cardiovascular-risk-an-observational-retrospective-study
#14
Victoria Aguilera, Tommaso Di Maira, Isabel Conde, Victoria Fornés-Ferrer, Carmen Vinaixa, Carmen Pallarés, Angela Carvalho-Gomes, Almudena Cubells, María García, Ángel Rubín, Salvador Benlloch, Luisa Gonzalez-Dieguez, Jose Miguel Molina, Lorena Puchades, F Xavier López-Labrador, Martin Prieto, Marina Berenguer
The association between cytomegalovirus (CMV) reactivation and cardiovascular risk has been reported in solid organ transplant populations; however, it has yet to be assessed in liver transplantation (LT). We aim to evaluate whether CMV reactivation is associated with cardiovascular events (CVE) in HCV-LT patients. LT patients (2010 and 2014) due to HCV cirrhosis were included. Clinically significant CMV (CS-CMV) was defined as viral load (VL) >5000 copies/ml, need of therapy or CMV disease. Baseline variables and endpoint measures (CVE, survival, severe recurrent hepatitis C, de novo tumors, and diabetes) were collected...
June 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29488657/roux-en-y-gastric-bypass-is-an-effective-bridge-to-kidney-transplantation-results-from-a-single-center
#15
Ian A Thomas, Jeffrey J Gaynor, Tameka Joseph, Nestor De La Cruz-Munoz, Junichiro Sageshima, Warren Kupin, Linda J Chen, Gaetano Ciancio, George W Burke, Adela D Mattiazzi, David Roth, Giselle Guerra
Body mass index (BMI) > 35-40 kg/m2 is often a contraindication, while Roux-en-Y gastric bypass (RYGB) is performed to enable kidney transplantation. This single-center retrospective study evaluated pre- and post-transplant outcomes of 31 morbidly obese patients with end-stage renal disease having RYGB before kidney transplantation between July 2009 and June 2014. Fourteen RYGB patients were subsequently transplanted. Nineteen recipients not having GB with a BMI ≥ 36 kg/m2 at transplantation were used as historical controls...
February 28, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29470354/poor-survival-after-retransplantation-in-nash-cirrhosis
#16
Avesh J Thuluvath, Po-Hung Chen, Paul J Thuluvath, Sergey Kantsevoy, Yulia Savva
BACKGROUND: Nonalcoholic steatohepatitis (NASH) cirrhosis is a common indication for liver transplantation (LT) in the U.S. There is a paucity of data on retransplantation (re-LT) in those who were initially transplanted for NASH. METHODS: We queried the UNOS data sets from 2002-2016 to analyze the outcomes of adults with NASH (n=128) and compared them to groups that received re-LT for cryptogenic cirrhosis (CC, n=189), alcoholic cirrhosis (AC, n=300) or autoimmune hepatitis cirrhosis (AIH-C, n=118) after excluding multiple-organ re-LT and individuals with HCC...
February 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29370406/neuropeptide-y-and-chronic-kidney-disease-progression-a-cohort-study
#17
Carmine Zoccali, Graziella D'arrigo, Daniela Leonardis, Patrizia Pizzini, Maurizio Postorino, Giovanni Tripepi, Francesca Mallamaci, Jan van den Brand, Arjan van Zuilen, Jack Wetzels, Michiel L Bots, Peter Blankestijn
Background: Neuropeptide Y (NPY) is a sympathetic neurotransmitter that has been implicated in various disorders including obesity, gastrointestinal and cardiovascular diseases. Methods: We investigated the relationship between circulating NPY and the progression of the glomerular filtration rate (GFR) and proteinuria and the risk for a combined renal endpoint (>30% GFR loss, dialysis/transplantation) in two European chronic kidney disease (CKD) cohorts including follow-up of 753 and 576 patients for 36 and 57 months, respectively...
January 23, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29329414/is-big-bad-or-bearable-long-term-renal-transplant-outcomes-in-obese-recipients
#18
O M McCloskey, A E Courtney, J A McCaughan, P Devine
No abstract text is available yet for this article.
January 10, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29303915/robotic-kidney-transplantation-dream-or-future
#19
Franck Bruyère, Nicolas Doumerc
PURPOSE OF REVIEW: Kidney transplantation is the preferred modality for the treatment of patients with end-stage renal disease. Robot-assisted kidney transplantation (RAKT) has been in use since 2002 to reduce morbidity in open kidney transplantation. The aim of this review is to highlight the most relevant publications on this challenging surgical topic. RECENT FINDINGS: Recent publications suggest that minimally invasive techniques in kidney transplantation, including RAKT, have shown promising results particularly with regard to complications and recovery, reducing postoperative pain and analgesic requirement with a better cosmetic result...
March 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29223620/impact-of-obesity-on-modality-longevity-residual-kidney-function-peritonitis-and-survival-among-incident-peritoneal-dialysis-patients
#20
Yoshitsugu Obi, Elani Streja, Rajnish Mehrotra, Matthew B Rivara, Connie M Rhee, Melissa Soohoo, Daniel L Gillen, Wei-Ling Lau, Csaba P Kovesdy, Kamyar Kalantar-Zadeh
BACKGROUND: The prevalence of severe obesity, often considered a contraindication to peritoneal dialysis (PD), has increased over time. However, mortality has decreased more rapidly in the PD population than the hemodialysis (HD) population in the United States. The association between obesity and clinical outcomes among patients with end-stage kidney disease remains unclear in the current era. STUDY DESIGN: Historical cohort study. SETTING & PARTICIPANTS: 15,573 incident PD patients from a large US dialysis organization (2007-2011)...
December 6, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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