keyword
MENU ▼
Read by QxMD icon Read
search

leiomyoma

keyword
https://www.readbyqxmd.com/read/29349391/inguinal-pain-and-fullness-due-to-an-intravascular-leiomyoma-in-the-external-iliac-vein
#1
Edvard Skripochnik, Lisa Marie Terrana, Nicos Labropoulos, Melissa Henretta, Todd Griffin, Shang A Loh
Intravascular leiomyomatosis (IVL) is a benign smooth muscle tumor that evolves from the pelvic veins and can spread to the central veins and heart. Cardiac involvement is the most commonly reported presentation. Initial diagnosis is difficult, and IVL is commonly misdiagnosed as thrombus or atrial myxoma. Appropriate imaging and a high clinical suspicion are required for accurate diagnosis. We report a rare case of IVL in the external iliac vein that recurred 4 years after hysterectomy. Only four cases have been reported in the literature to involve the external iliac vein as it has no direct connection to pelvic venous drainage...
June 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29348564/inhibition-of-wnt-%C3%AE-catenin-signaling-under-serum-starvation-and-hypoxia-induces-adipocytic-transdifferentiation-in-human-leiomyoma-cells
#2
Hiroshi Harada, Yojiro Tsuda, Kei Yabuki, Eisuke Shiba, Kazuyoshi Uchihashi, Atsuji Matsuyama, Yoshihisa Fujino, Toru Hachisuga, Masanori Hisaoka
Fatty metamorphosis is an uncommon alteration in uterine leiomyoma (i.e., lipoleiomyoma), and the pathogenetic mechanisms underlying this phenomenon remain poorly understood. Because a conditional deletion of β-catenin, a major transducer of the canonical Wingless/integrated (WNT) pathway, in the developing mouse uterus can induce adipogenesis in the myometrium, it is hypothesized that inhibition of the WNT/β-catenin signaling may be also involved in the development of fat cells within uterine leiomyoma. In the current study, which was performed to address this point, intracytoplasmic lipid droplets were detectable in cultured human leiomyoma cells by treatment with a potent tankyrase inhibitor, XAV939, which antagonizes β-catenin, in a serum-starved culture medium without additional adipogenesis-inducing agents or supplements, and showed increasing accumulation in a time-dependent manner...
January 18, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29346056/esophageal-leiomyoma-in-a-dog-causing-esophageal-distension-and-treated-by-transcardial-placement-of-a-self-expanding-covered-nitinol-esophageal-stent
#3
Elisabeth M Robin, Pascaline B Pey, Pauline de Fornel-Thibaud, Pierre H M Moissonnier, Valérie Freiche
CASE DESCRIPTION A 10-year-old spayed female Rottweiler was referred for evaluation because of a 2-month history of regurgitation and weight loss, despite no apparent change in appetite. The dog had received antiemetic and antacid treatment, without improvement. CLINICAL FINDINGS Physical examination revealed a low body condition score (2/5), but other findings were unremarkable. Diffuse, global esophageal dilatation was noted on plain thoracic radiographs, and normal motility was confirmed through videofluoroscopic evaluation of swallowing...
February 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29344486/acute-presentation-of-mesectodermal-leiomyoma-of-the-ciliary-body
#4
Jenna May Kim, Laura Bressler Hall, Maxwell Elia, Michael S Ehrlich, Miguel A Materin, John H Sinard
Purpose: We report a case of acutely presenting mesectodermal leiomyoma of the ciliary body in a 29-year-old female who reported waking up with swollen eyelids of the right eye and light-perception vision. The affected eye had elevated intraocular pressure, a flat anterior chamber, and a pale, round mass arising from the nasal ciliary body, invading the angle and protruding into the visual axis posterior to the lens. Within days, the visual acuity decreased to no light perception. The eye was enucleated...
November 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344475/ring-shaped-leiomyoma-of-the-ciliary-body
#5
Steven H Tucker, Eszter Szalai, Mark Rivellese, Hans Grossniklaus
Purpose: Ciliary body mesectodermal leiomyoma is a rare, benign smooth muscle tumor that typically presents in women in the second to fourth decade of life. The diagnosis is typically based on clinical color, funduscopic appearance, transillumination properties, and B-scan ultrasonography. Methods: We present a patient with a 360° ciliary body mass with transillumination and ultrasonographic properties consistent with a ring melanoma. Results: This case emphasizes the difficulty in differentiating the benign leiomyoma from similar appearing malignant tumors such as melanoma...
November 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29339836/the-role-of-metabolic-enzymes-in-mesenchymal-tumors-and-tumor-syndromes-genetics-pathology-and-molecular-mechanisms
#6
REVIEW
Inga-Marie Schaefer, Jason L Hornick, Judith V M G Bovée
The discovery of mutations in genes encoding the metabolic enzymes isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), and fumarate hydratase (FH) has expanded our understanding not only of altered metabolic pathways but also epigenetic dysregulation in cancer. IDH1/2 mutations occur in enchondromas and chondrosarcomas in patients with the non-hereditary enchondromatosis syndromes Ollier disease and Maffucci syndrome and in sporadic tumors. IDH1/2 mutations result in excess production of the oncometabolite (D)-2-hydroxyglutarate...
January 16, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29338993/peritoneal-sarcomatosis-5-years-after-laparoscopic-morcellation-of-uterine-leiomyoma
#7
Marco Petrillo, Margherita Dessole, Vito Chiantera
No abstract text is available yet for this article.
January 12, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29338669/successful-operative-treatment-of-uterine-leiomyoma-with-extensive-intravenous-extension-to-the-ivc-right-heart-and-pulmonary-arteries
#8
Ranjeet Brar, Alicia Skervin, Karim El-Sakka, Andrew Fish, Michael Lewis
INTRODUCTION: Intravenous extension of benign uterine leiomyomata ('fibroids'), in the absence of discrete metastatic disease has rarely been reported. 'Fibroids' remain one of the most common premenopausal uterine pathologies. METHODS AND RESULTS: We report the diagnosis and multidisciplinary led operative management of a 52-year-old woman with a histologically benign, but biologically aggressive, uterine leiomyoma with intravenous extension to the inferior vena cava (IVC), right heart and pulmonary arteries...
January 17, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29335010/acute-intestinal-obstruction-due-to-extrinsic-compression-by-previa-myoma-and-ectopic-pregnancy-a-case-report
#9
Harissou Adamou, Ibrahim Amadou Magagi, Souleymane Oumarou Garba, Oumarou Habou
BACKGROUND: Acute intestinal obstruction during pregnancy is a rare digestive surgical emergency with significant maternal and fetal mortality. Diagnosis is difficult, often delaying the management. Here, we report an exceptional association of mechanical acute intestinal obstruction due to compression by previa uterine leiomyoma, and a ruptured ectopic pregnancy. CASE PRESENTATION: This is the case report of a 43-year-old primiparous black woman from a rural area, who was admitted to the surgical emergency department for acute intestinal obstruction...
January 16, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29334138/move-knife-tip-on-the-thoracic-aorta-a-high-risk-submucosal-tunneling-endoscopic-resection-ster-procedure-for-a-puzzle-submucosal-mass-in-esophagus-with-video
#10
Wengang Zhang, Ningli Chai, Enqiang Linghu
A 43-year-old men was found an esophageal submucosal mass at 26 cm from the incisors; and preoperative EUS suggested a leiomyoma in MP layer. STER1, 2 , deriving from POEM3, 4 , was performed, and an inverse T incision5 was carried out firstly. Subsequently, a submucosal tunnel was established extending to the distal esophagus; and a mass, covered with MP tissue, was discovered (Figure 1); particularly, the mass was going up and down rhythmically, and had soft touch; given the possibility of aorta compression or cyst, ECDUS was conducted and uncovered a homogeneous hypoechoic lesion, just against thoracic aorta (Figure 2)...
January 15, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29333096/analysis-of-med12-mutation-in-multiple-uterine-leiomyomas-in-south-korean-patients
#11
Minkyoung Lee, Keunyoung Cheon, Boah Chae, Hyesung Hwang, Hyun-Kyung Kim, Youn-Jee Chung, Jae-Yen Song, Hyun-Hee Cho, Jang-Heub Kim, Mee-Ran Kim
Uterine leiomyomas are one of the most common benign gynecologic tumors, but the exact causes are not completely understood. In 2011, through DNA sequencing, MED12 mutation was discovered in approximately 71% of uterine leiomyomas. Several recent studies confirmed the high frequency of MED12 mutation in uterine leiomyoma. Nevertheless, no study has been done on MED12 mutation in the case of patients with multiple leiomyomas in a patient. The purpose of this study was to investigate the frequency of MED12 mutations in uterine leiomyomas of South Korean patients...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29332133/fumarate-hydratase-fh-deficiency-in-uterine-leiomyomas-recognition-by-histological-features-versus-blind-immunoscreening
#12
Lisa Siegler, Ramona Erber, Stefanie Burghaus, Tobias Brodkorb, David Wachter, Nafisa Wilkinson, James Bolton, Helen Stringfellow, Florian Haller, Matthias W Beckmann, Arndt Hartmann, Abbas Agaimy
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is a rare autosomal dominant disease caused by germline mutations in the fumarate hydratase (FH) gene. Affected individuals develop cutaneous and uterine leiomyomas and aggressive RCC. To date, only few publications described the frequency and morphology of FH-deficient uterine leiomyomas. We reviewed 22 cases collected over 8 years from routine and consultation files based on distinctive histological features. In addition, we screened 580 consecutive uterine leiomyomas from 484 patients, 23 extra-uterine and 8 uterine leiomyosarcomas, and 6 leiomyomas with bizarre nuclei for FH loss using immunohistochemistry (IHC) on tissue microarrays (TMAs)...
January 13, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29329131/alk-gene-fusions-in-epithelioid-fibrous-histiocytoma-a-study-of-14-cases-with-new-histopathological-findings
#13
Dmitry V Kazakov, Liubov Kyrpychova, Petr Martinek, Petr Grossmann, Petr Steiner, Tomas Vanecek, Michal Pavlovsky, Vladimir Bencik, Michael Michal, Michal Michal
Previous studies showed that ALK is often positive in epithelioid fibrous histiocytoma (EFH). Two cases of EFH with ALK gene fusions have been recorded. Our objective was to study a series of EFH to present histopathological variations of EFH, identify novel ALK gene fusions, and determine whether there is a correlation between histopathological features and particular gene. We investigated 14 cases of EFH, all ALK immunopositive. The cases were assessed histopathologically as well as for ALK and TFE-3 rearrangements using FISH and ALK gene fusions using next-generation sequencing...
January 11, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29327710/genome-profiling-is-an-efficient-tool-to-avoid-the-stump-classification-of-uterine-smooth-muscle-lesions-a-comprehensive-array-genomic-hybridization-analysis-of-77-tumors
#14
Sabrina Croce, Agnès Ducoulombier, Agnès Ribeiro, Tom Lesluyes, Jean-Christophe Noel, Frédéric Amant, Louis Guillou, Eberhard Stoeckle, Mojgan Devouassoux-Shisheboran, Nicolas Penel, Anne Floquet, Laurent Arnould, Frédéric Guyon, Florence Mishellany, Camille Chakiba, Tine Cuppens, Michal Zikan, Agnès Leroux, Eric Frouin, Isabelle Farre, Catherine Genestie, Isabelle Valo, Gaëtan MacGrogan, Frédéric Chibon
The diagnosis of a uterine smooth muscle lesion is, in the majority of cases, straightforward. However, in a small number of cases, the morphological criteria used in such lesions cannot differentiate with certainty a benign from a malignant lesion and a diagnosis of smooth muscle tumor with uncertain malignant potential (STUMP) is made. Uterine leiomyosarcomas are often easy to diagnose but it is difficult or even impossible to identify a prognostic factor at the moment of the diagnosis with the exception of the stage...
January 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29321437/esophageal-granular-cell-tumors-can-be-differentiated-from-leiomyomas-using-endoscopic-ultrasonography
#15
Masaya Iwamuro, Takehiro Tanaka, Hiromitsu Kanzaki, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada
Objective Although esophageal granular cell tumors have been reported to present as hypoechoic tumors, we noticed that their echogenicity is similar to that of the submucosal layer. We investigated the sonographic features of esophageal granular cell tumors and the diagnostic accuracy of the features. Methods Seven patients with esophageal granular cell tumors who underwent endoscopic ultrasonography were retrospectively reviewed. Thirteen patients with esophageal leiomyoma were selected as historical control subjects...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29319490/primary-intracranial-leiomyoma-in-an-immunocompetent-patient
#16
Rebeca Alvarez, Michael Schild, Thomas J Cummings
No abstract text is available yet for this article.
January 10, 2018: Clinical Neuropathology
https://www.readbyqxmd.com/read/29318556/human-tumor-tissue-based-3d-in-vitro-invasion-assays
#17
Pirjo Åström, Ritva Heljasvaara, Pia Nyberg, Ahmed Al-Samadi, Tuula Salo
Here we describe a protocol to utilize human benign leiomyoma tissue in in vitro 3D model that enables an assessment of cell invasion. The chapter also describes detailed instructions for image analysis to quantify the results. Leiomyoma is a benign tumor of the uterus which mimics authentic components of the tumor microenvironment including fibroblasts, vessels, collagen fibers, and extracellular protein composition. The leiomyoma invasion model represents a superior 3D model for cell invasion studies compared to the other non-human organotypic models...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29317071/recently-discovered-interstitial-cells-telocytes-as-players-in-the-pathogenesis-of-uterine-leiomyomas
#18
Ivan Varga, Martin Klein, Ladislav Urban, Ludovit Danihel, Stefan Polak, Ludovit Danihel
Uterine telocytes are interstitial cells characterized by a very long cytoplasmic prolongations, which form a 3D network, functionally integrating a wide variety of different cells. Leiomyomas (uterine fibroids) are benign tumors, which pose a huge threat concerning various health problems in women affected by this condition. The exact cause of leiomyomas development is, however, still largely unknown. Therefore, in an attempt to clarify their etiology, we performed an immunohistochemical characterization of telocytes in leiomyomas as well as in normal myometrium...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29311722/erratum-use-of-a-novel-submucosal-tunneling-and-endoscopic-resection-ster-technique-for-the-removal-of-an-esophageal-leiomyoma
#19
Madhusudhan R Sanaka, Malav P Parikh, Prashanthi N Thota, Niyati M Gupta, Siva Raja
This corrects the article DOI: 10.1038/ajg.2017.168.
January 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29310403/multilocular-cystic-leiomyoma-of-the-anterolateral-abdominal-wall-a-case-report-and-literature-review
#20
Kenji Yorita, Yu Tanaka, Koki Hirano, Michio Kuwahara, Kimiko Nakatani, Masaharu Fukunaga, Abbas Agaimy
RATIONALE: Leiomyomas arising from the anterolateral abdominal wall are uncommon, and their pathogenesis remains unknown. We present the 15th case of such a tumor, having this unique tumor morphology, followed by a detailed discussion on disease pathogenesis. PATIENT CONCERNS: A 48-year-old, asymptomatic perimenopausal, multiparous Japanese woman presented with a left-sided pelvic mass. She had no history of previous surgeries or uterine leiomyomas. Although a transabdominal ultrasonogram raised suspicions of an ovarian tumor, a transvaginal ultrasonogram confirmed normal ovaries...
December 2017: Medicine (Baltimore)
keyword
keyword
44736
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"