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https://www.readbyqxmd.com/read/28748899/primary-intracranial-leiomyoma-in-renal-transplant-recipient
#1
Upasana Patel, Nirajkumar Patel
Leiomyoma, the benign tumor of smooth muscle cell origin, is commonly seen in genitourinary and gastrointestinal tracts. Primary intracranial leiomyoma, however, is extremely rare occurrence. We hereby report a case of Epstein-Barr negative primary intracranial leiomyoma in a middle-aged renal transplant recipient, which mimicked left frontal parasagittal meningioma on neuroimaging. The tumor was completely excised and diagnosis of leiomyoma was clinched on pathological analysis with immunohistochemistry. The patient improved after tumor removal, and no evidence of tumor recurrence was noted on follow-up study after 10 months postsurgically...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28747229/vaginal-metastasis-as-the-initial-presentation-of-leiomyosarcoma-a-case-report
#2
Cecilia Villalaín-González, Álvaro Tejerizo-García, Patricia Lopez-Garcia, Gregorio López-González, Ma Reyes Oliver-Perez, Jesús S Jiménez-López
BACKGROUND: Uterine leiomyosarcomas are very rare and highly aggressive tumors that have a high rate of recurrence and poor prognosis, even when early diagnosed. Due to their relative rarity, there is limited research on optimal management strategies. CASE PRESENTATION: A 60-year-old woman with a history of an asymptomatic uterine leiomyoma presented in October 2015 with postmenopausal bleeding and a friable vaginal cyst that bled when palpated. A partial cystectomy was performed, and malignant-like cystic and solid components were identified...
July 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28743407/prevalence-of-undiagnosed-uterine-leiomyosarcoma-in-women-undergoing-hysterectomy-or-myomectomy-for-benign-indications
#3
Sören Lange, Nicola Pluchino, Aurore Fehlmann, Roberto Marci, Meriem Boukrid, Inès Ben Jazia, Patrick Petignat, Jean Dubuisson
OBJECTIVE: To determine the prevalence of undiagnosed uterine leiomyosarcoma (LMS) in women undergoing hysterectomy or myomectomy for suspected benign leiomyomas. STUDY DESIGN: Retrospective, single-centre, cohort study. Information for all gynaecological procedures for suspected benign leiomyomas between 1993 and 2016 was extracted from the hospital database. The prevalence of LMS was calculated by surgery type and age group. RESULTS: The prevalence of LMS was 1...
June 21, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28743098/giant-fibro-epithelial-polyp-in-a-young-girl-a-rare-case-report
#4
Anil Kumar, Nadia Hasin, Amit Kumar Sinha, Subhash Kumar, Punam Bhadani
INTRODUCTION: Fibro epithelial Polyp (FEP) is a polypoid outgrowth of epidermis and dermal fibro vascular tissue. This polyp is most commonly found in oral cavity, neck and axilla, though any skin fold may be affected like groin. These polyps are usually less than 5cm in size and rarely occur before 4th decade of life. Excision is the treatment of choice for such lesion. PRESENTATION OF CASE: A 20year old female patient presented with a large pedunculated mass originating from the left groin area extending up to the left knee joint...
July 15, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28741605/a-rare-case-of-intramural-m%C3%A3-llerian-adenosarcoma-arising-from-adenomyosis-of-the-uterus
#5
Sun-Jae Lee, Ji Y Park
Müllerian adenosarcomas usually arise as polypoid masses in the endometrium of post-menopausal women. Occasionally, these tumors arise in the cervix, vagina, broad and round ligaments, ovaries and rarely in extragenital sites; these cases are generally associated with endometriosis. We experienced a rare case of extraendometrial, intramural adenosarcoma arising in a patient with adenomyosis. A 40-year-old woman presented with sudden-onset suprapubic pain. The imaging findings suggested leiomyoma with cystic degeneration in the uterine fundus...
July 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28737576/hereditary-leiomyomatosis-and-renal-cell-carcinoma-syndrome-combined-with-adrenocortical-carcinoma-on-18f-fdg-pet-ct
#6
Xiuyu Guo, Haojun Chen, Hao Fu, Hua Wu
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is a recognized distinct phenotypic variant of multiple cutaneous and uterine leiomyomatosis. The present case reports an extremely rare case of HLRCC syndrome combined with adrenocortical carcinoma. The case suggests that HLRCC should be considered in any young patient with bulky uterine leiomyomas and renal cell cancer, and F-FDG PET/CT can help detect unexpected additional primary malignancy in a patient with known cancer.
July 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28734973/minimally-invasive-approaches-to-myoma-management
#7
REVIEW
Julian A Gingold, Ndeye-Aicha Gueye, Tommaso Falcone
Patients affected by the presence of leiomyomas may incur a substantial physical, emotional, social and financial toll as well as losses in their quality of life. Although many myomas are not amenable to medical therapy or hysteroscopic resection, many others are amenable to minimally invasive surgical approaches. In patients who prefer to retain their fertility, laparoscopic myomectomy should be considered the intervention of choice. In this review we expand on the surgical techniques of both conventional laparoscopic and robotic-assisted myomectomies...
July 19, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28731956/laparoscopic-intragastric-surgery-with-endoscopic-assistance-a-2-gastrostomy-approach-with-multiple-applications
#8
Emmanuel Gabriel, Kelly Rosso, Danish Shahab, Rupen Shah, Andrew Bain, Moshim Kukar, Steven N Hochwald
PURPOSE: Laparoscopic intragastric resection is a surgical modality with acceptable oncologic outcomes for gastrointestinal stromal tumors and leiomyomas, particularly for masses located near the gastroesophageal junction (GEJ). We describe our technique of 2 gastrostomy laparoscopic, intragastric resection with endoscopic assistance. METHODS: We detail our technique and report a unique application of this versatile approach. RESULTS: Between December 2015 and July 2016, 4 patients underwent our combined technique of intragastric surgery...
July 20, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28731868/inflammatory-myofibroblastic-tumors-of-the-female-genital-tract-are-under-recognized-a-low-threshold-for-alk-immunohistochemistry-is-required
#9
Justine L Pickett, Angela Chou, Juliana A Andrici, Adele Clarkson, Loretta Sioson, Amy Sheen, Jessica Reagh, Fedaa Najdawi, Yoomee Kim, Denise Riley, Jayne Maidens, David Nevell, Kirsten McIlroy, Susan Valmadre, Greg Gard, Russell Hogg, John Turchini, Gregory Robertson, Michael Friedlander, Anthony J Gill
Inflammatory myofibroblastic tumor (IMT) of the female genital tract is under-recognized. We investigated the prevalence of ALK-positive IMT in lesions previously diagnosed as gynecologic smooth muscle tumors. Immunohistochemistry (IHC) for ALK was performed on tissue microarrays of unselected tumors resected from 2009 to 2013. Three of 1176 (0.26%) "leiomyomas" and 1 of 44 (2.3%) "leiomyosarcomas" were ALK IHC positive, confirmed translocated by fluorescence in situ hybridization (FISH) and therefore more appropriately classified as IMT...
July 20, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28731043/gastroblastoma-harbors-a-recurrent-somatic-malat1-gli1-fusion-gene
#10
Rondell P Graham, Asha A Nair, Jaime I Davila, Long Jin, Jin Jen, William R Sukov, Tsung-Teh Wu, Henry D Appelman, Jorge Torres-Mora, Kyle D Perry, Lizhi Zhang, Sara M Kloft-Nelson, Ryan A Knudson, Patricia T Greipp, Andrew L Folpe
Gastroblastoma is a rare distinctive biphasic tumor of the stomach. The molecular biology of gastroblastoma has not been studied, and no affirmative diagnostic markers have been developed. We retrieved two gastroblastomas from the consultation practices of the authors and performed transcriptome sequencing on formalin-fixed paraffin-embedded tissue. Recurrent predicted fusion genes were validated at genomic and RNA levels. The presence of the fusion gene was confirmed on two additional paraffin-embedded cases of gastroblastoma...
July 21, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28730656/spontaneous-pregnancy-during-ulipristal-acetate-treatment-of-giant-uterine-leiomyoma
#11
Z Hrgovic, D Habek, J Cerkez Habek, I Hrgovic, S Jerkovic Gulin, D Gulin
WHAT IS KNOWN AND OBJECTIVE: Ulipristal acetate, a progesterone receptor modulator, pharmacologically inhibits endometrial proliferation and thereby prevents pregnancy. It is primarily used as emergency contraception, but also for the treatment of fibroids in women of reproductive age. There have been no published cases of pregnancy, while on therapy with ulipristal acetate. CASE DESCRIPTION: In this article, we present a case report of spontaneous pregnancy during ulipristal acetate therapy...
July 21, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28730217/novel-perspectives-on-gastrointestinal-stromal-tumors-gists
#12
Bogdan Stelian Mastalier Manolescu, Cristiana Gabriela Popp, Valentin Popescu, Dan Andraş, Sabina Andrada Zurac, Costin Berceanu, Aida TincuŢa Petca
Since they were described, gastrointestinal stromal tumors (GISTs) are, for pathologists and not only for them, a subject of controversy regarding histological origin, differentiation, nomenclature, malignant potential and prognosis. Before 1998, there were no certainties that GISTs were fundamentally different from other types of abdominal cancers in the big family of mesenchymal tumors. Before the discovery of KIT gene mutations, GISTs were most often classified as leiomyoma, leiomyosarcoma, leiomyoblastoma, and gastrointestinal autonomic nerve tumor...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28725059/use-of-a-novel-submucosal-tunneling-and-endoscopic-resection-ster-technique-for-the-removal-of-an-esophageal-leiomyoma
#13
Madhusudhan R Sanaka, Malav P Parikh, Prashanthi N Thota, Niyati M Gupta, Siva Raja
No abstract text is available yet for this article.
July 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28724848/laparoscopic-excision-of-a-uterine-adenomatoid-tumor-and-a-coexisting-ovarian-teratoma-a-case-report-and-literature-review
#14
Tomohiko Matsuhashi, Ryoko Matsui, Chikako Hasegawa, Tsutomu Hatori, Seiryu Kamoi, Toshiyuki Takeshita
Adenomatoid tumors (ATs) are rare, benign neoplasms occurring mainly in reproductive organs such as the uterus, ovaries, fallopian tubes, and testes. Uterine adenomatoid tumors (UATs) are generally incidentally diagnosed during histopathological examination of excisional biopsies performed for other indications, most commonly uterine leiomyomas. We herein present a 38-year-old woman who underwent laparoscopic excision of a uterine leiomyoma and a right ovarian teratoma. Microscopic examination of the excisional biopsy revealed that the enucleated uterine tumor was composed of proliferating glandular tissue covered with single-layered cells that were surrounded by proliferating smooth muscle cells, corresponding exactly to the features of UATs...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28722090/-evaluation-of-a-new-closure-technique-of-large-defects-after-endoscopic-full-thickness-resection
#15
Xiao Liu, Lizhou Dou, Yong Liu, Shun He, Yueming Zhang, Xinying Yu, Yan Ke, Xudong Liu, Ruigang Wang, Guiqi Wang
OBJECTIVE: To investigate the security and efficacy of a new endoscopic closure method of large defects after endoscopic full-thickness resection (EFTR) double purse-string suture using two endoloops and metallic clips via single-channel endoscopy. METHODS: Clinical data of 23 cases with submucosal tumors (SMT) who received endoscopic resection from June 2015 to July 2016 in our National Cancer Center were collected. For gastric and esophageal SMTs or the mucosa layer injured during submucosal tunneling endoscopic resection (STER), double purse-string suture was conducted after EFTR...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28717557/uterine-lipoleiomyoma-a-report-of-two-cases
#16
Haji Mohammed Nazir, Sankesh Mehta, C R Seena, N Kulasekaran
We report two cases of uterine lipoleiomyoma in postmenopausal women of ages 52 and 55 years, who presented with complaints of leukorrhea and lower abdominal pain, respectively. Lipoleiomyoma is a rare benign variant of leiomyoma, having an incidence of 0.03%-0.2%. These are benign pelvic tumors which are usually asymptomatic and commonly occur in obese postmenopausal women. However, they can occasionally present with typical leiomyoma symptoms. Imaging plays a crucial role in the diagnosis of benign pelvic tumors...
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28708319/experimental-study-on-ablation-of-leiomyoma-by-combination-high-intensity-focused-ultrasound-and-iodized-oil-in-vitro
#17
Zhi-Gang Liang, Yi Gao, Xiao-Yan Ren, Cui Sun, Heng-Fang Gu, Meng Mou, Yan-Bing Xiao
AIM: The aim of the current study was to investigate whether iodized oil (IO) enhances high-intensity focused ultrasound (HIFU) ablation of uterine leiomyoma and to determine the features of hyperechoic changes in the target region. METHODS: Forty samples of uterine leiomyoma were randomly divided into an experimental group and a control group. In the experimental group, the leiomyoma was ablated by HIFU 30 min after 1 mL of iodized oil had been injected into the center of the myoma...
July 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28702500/surgical-management-of-a-large-neurilemmoma-like-leiomyoma-of-the-uterine-cervix-mimicking-a-retroperitoneal-tumor
#18
David A Morales F, Oscar Suescún, Laura Martínez, Isabel Dulcey
•A large cervical neurilemmoma-like leiomyoma can simulate a retroperitoneal tumor.•They are extremely rare tumors that require adequate bleeding control.•Comprehensive anatomo-pathological study should be done to rule out malignancy.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28700441/leiomyoma-with-bizarre-nuclei-clinical-and-pathologic-features-of-30-patients
#19
Mehmet Kefeli, Sultan Caliskan, Emel Kurtoglu, Levent Yildiz, Arif Kokcu
Leiomyoma with bizarre nuclei (LBN) have significant cytologic atypia, but high mitotic rate and tumor cell necrosis are absent. Although it is a benign leiomyoma variant, recurrent cases have been described. In this study, we investigated the clinical and pathologic features of LBN and compared them with related studies. A total of 30 patients diagnosed with LBN in our department were included in this study. In all cases, clinical data (age, complaint, surgery type), macroscopic features (size, location, number of leiomyomas, necrosis, and hemorrhage), microscopic features (bizarre cell distribution, bizarre cell density, cellularity, mitotic rate, tumor margin, necrosis, nuclear pseudoinclusions, karyorrhectic nuclei, prominent eosinophilic nucleoli with perinucleolar clearing, cytoplasmic eosinophilic inclusions, staghorn vessels, and alveolar-type edema), and follow-up data (recurrence and survival period) were evaluated...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28700435/ifitm1-outperforms-cd10-in-differentiating-low-grade-endometrial-stromal-sarcomas-from-smooth-muscle-neoplasms-of-the-uterus
#20
Aurelia Busca, Previn Gulavita, Carlos Parra-Herran, Shahidul Islam
Distinguishing between uterine neoplasms of smooth muscle and endometrial stromal origin is a frequent diagnostic challenge. We investigated the staining pattern of interferon-induced transmembrane protein-1 (IFITM1), a novel endometrial stromal marker, in endometrial and smooth muscle uterine neoplasms and compared it with CD10 in its ability to differentiate between these two groups. Immunohistochemistry for IFITM1 and CD10 was performed in 20 cases of smooth muscle neoplasms (10 cases leiomyoma, 10 cases leiomyosarcoma), 14 cases of endometrial stromal sarcoma (ESS) (12 cases of low grade and 2 cases of high grade) and 12 cases of carcinosarcoma...
July 11, 2017: International Journal of Gynecological Pathology
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