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https://www.readbyqxmd.com/read/29785389/pelvic-and-pulmonary-benign-metastasizing-leiomyoma-a-case-report
#1
Jennifer B Bakkensen, Wesley Samore, Pietro Bortoletto, Cynthia C Morton, Raymond M Anchan
Seven years after she had a total abdominal hysterectomy for benign leiomyomas, a 46-year-old woman presented with a pelvic mass and multiple pulmonary nodules. She underwent resection of the mass and core needle biopsy of a pulmonary lesion. Histopathologic analysis revealed that both the pelvic and the pulmonary lesions were consistent with benign leiomyomas. Benign metastasizing leiomyoma should be considered if a woman of reproductive age and with a history of leiomyomas presents with extrauterine nodules without evidence of malignancy...
April 2018: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29783003/non-malignant-sequelae-following-unconfined-power-morcellation-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2
#2
Hao M Zhang, Lee A Christianson, Claire L Templeman, Scott E Lentz
STUDY OBJECTIVE: To identify the incidence of repeat surgery and subsequent findings following the performance of unconfined uterine power morcellation. DESIGN: A retrospective descriptive study (Canadian Task Force II-2) SETTING: Southern California Kaiser Permanente Medical Centers PATIENTS: Women (n=5154) who underwent laparoscopic supra-cervical hysterectomy (LSH) with unconfined power morcellation. MEASUREMENTS AND MAIN RESULTS: Of the 5154 cases, 279 (5...
May 18, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29780819/a-comprehensive-review-of-the-pharmacologic-management-of-uterine-leiomyoma
#3
REVIEW
Terrence D Lewis, Minnie Malik, Joy Britten, Angelo Macapagal San Pablo, William H Catherino
Uterine leiomyomata are the most common benign tumors of the gynecologic tract impacting up to 80% of women by 50 years of age. It is well established that these tumors are the leading cause for hysterectomy with an estimated total financial burden greater than $30 billion per year in the United States. However, for the woman who desires future fertility or is a poor surgical candidate, definitive management with hysterectomy is not an optimal management plan. Typical gynecologic symptoms of leiomyoma include infertility, abnormal uterine bleeding (AUB)/heavy menstrual bleeding (HMB) and/or intermenstrual bleeding (IMB) with resulting iron-deficiency anemia, pelvic pressure and pain, urinary incontinence, and dysmenorrhea...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29780788/successfully-removed-uterine-angioleiomyoma-by-robot-assisted-laparoscopic-myomectomy
#4
Hyunkyung Kim, Jin-Ju Lee, Yonghee Choi, Minkyoung Lee, Hye-Jin Hwang, Youn-Jee Chung, Hyun-Hee Cho, Mee-Ran Kim
Angioleiomyoma is a rare type of leiomyoma variant and there are a few cases reported to date. Herein, we present a case of angioleiomyoma in a 36-year-old woman with lower abdominal pain, initially diagnosed by degenerated uterine leiomyoma. The transvaginal ultrasonogram showed an ovoid-shaped heterogeneously hyperechoic lesion in left cornual site of uterus and pelvic magnetic resonance image showed an about 5.1 cm sized heterogenous T2 intermediate high mass with poor enhancement. The patient underwent a robot-assisted laparoscopic myomectomy, and final histopathologic diagnosis revealed uterine angioleiomyoma...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29780783/doppler-sonography-of-perifibroid-and-intrafibroid-arteries-of-uterine-leiomyomas
#5
Bukunmi Michael Idowu, Bolanle Olubunmi Ibitoye
Objective: To sonographically evaluate the dominant fibroid nodule vascularity and flow velocity pattern of perifibroid and intrafibroid arteries. Methods: We recruited 140 women with uterine fibroids. Their uteri were scanned to determine the vascularity of fibroid nodules and the Doppler indices of the fibroid arteries. Results: The median volume of the dominant leiomyoma nodule was 133 cm3 (range=1.5-2,575 cm3 ). Eighty-three subjects (59...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29779471/hypoxia-induces-hypoxia-inducible-factor-1%C3%AE-and-potential-hif-responsive-gene-expression-in-uterine-leiomyoma
#6
Hiroshi Ishikawa, Linlin Xu, Kunizui Sone, Tatsuya Kobayashi, Guiwen Wang, Makio Shozu
Uterine leiomyoma is characterized by abundant extracellular matrix and broad avascular areas, both constantly resulting in hypoxia, suggesting some hypoxia-induced response function. Here, we examined whether hypoxia-inducible factor 1α (HIF-1α)- mediated hypoxic response function in uterine leiomyoma. Immunoblotting detected higher basal HIF-1α protein expression in nuclear extracts from uterine leiomyoma tissues than in those from the adjacent myometrium ( P = .0011). Immunohistochemical analysis revealed the presence of HIF-1α-positive cellular components in both leiomyoma and surrounding myometrial tissues...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29778390/next-generation-sequencing-reveals-differentially-expressed-small-noncoding-rnas-in-uterine-leiomyoma
#7
Tsai-Der Chuang, Yeming Xie, Wei Yan, Omid Khorram
OBJECTIVE: To determine the expression profile of small noncoding RNAs (sncRNAs) in leiomyoma, which has not been investigated to date. DESIGN: Laboratory-based investigation. SETTING: Academic center. PATIENT(S): Women undergoing hysterectomy for benign indications. INTERVENTION(S): Next-generation sequencing and screening of an sncRNA database with confirmatory analysis by quantitative reverse-transcription polymerase chain reaction (qRT-PCR)...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29772408/hysteroscopic-myomectomy-of-a-large-submucosal-leiomyoma-with-novel-use-of-fluid-warming
#8
Tess Chase, Stephanie J Estes
Uterine fibroid size is often considered a limiting factor for considering the surgical approach to myomectomy. In this case, a 35-year-old woman presented with heavy menstrual bleeding and desire for fertility. An ultrasound three months prior could not assess the endometrium and suggested leiomyoma. Magnetic resonance imaging of the pelvis identified a fundal submucosal myoma measuring 6.8 × 7.1 × 3.5 cm. A planned staged hysteroscopic resection of the large submucosal fibroid with intramural component was achieved...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29768663/death-of-a-female-prostitute-due-to-intestinal-obstruction-by-an-unknown-substance
#9
Marek Dokoupil, Klára Marecová, Petr Handlos, Petr Březina
A young adult black female, known to be a prostitute and suspected of smuggling narcotics, was found dead in her apartment in a state of early decomposition. Oval-shaped gray-white masses of exogenous origin protruded from the anus. The autopsy showed dilatation of the folds of the large intestine, which were almost completely filled with these oval-shaped gray-white masses of foreign material. The uterus was enlarged with multiple large leiomyomas. Toxicological tests of blood and the foreign material revealed no toxicologically relevant substances...
May 16, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29765929/gonadotropin-releasing-hormone-agonist-plus-aromatase-inhibitor-in-the-treatment-of-uterine-leiomyoma-in-near-menopause-patient-a-case-series-study
#10
Sanam Moradan
Objectives: There are many drugs for of symptomatic fibroids. Gonadotropin-releasing hormone (GnRH) agonists are the well known drugs. Also, aromatase inhibitors are effective. All published studies surveyed the effect of one of these two drugs. In this study as the first study decided to evaluate the effectiveness of the combination of GnRH agonists + aromatise inhibitor on the uterine fibroids. Methods: A cross-sectional prospective case series study was performed on 10 known cases of uterine fibroids late perimenopause, at least 3 myomas >5 cm, abnormal uterine bleeding and anemia due to fibroids, candidate for hysterectomy, no tendency to surgery...
April 2018: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29764714/bronchoscopic-resection-of-a-tracheobronchial-leiomyoma-in-a-pregnant-patient
#11
K Falce, E Guy, D Hyman, T Hotze, D Lazarus, V Bandi, J Parchem, C Davidson, U Munnur
Flexible bronchoscopy, therapeutic bronchoscopy and other procedures requiring anesthesia are generally avoided in pregnancy and postponed until after delivery if possible. We report a case of a parturient with an abnormal chest radiograph and mild obstructive symptoms of unknown etiology. At bronchoscopy, a tumor associated with post-obstructive suppuration was found and excised using electrocautery snare and cryotherapy, for restoration of airway patency. Coordination between pulmonary, obstetric, anesthesia, neonatology and thoracic surgery services was essential in ensuring success and the safety of the mother and fetus...
April 10, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29764009/a-rare-duodenal-subepithelial-tumor-duodenal-schwannoma
#12
Dong Hwahn Kahng, Gwang Ha Kim, Sang Gyu Park, So Jeong Lee, Do Youn Park
Schwannomas are uncommon neoplasms that arise from Schwann cells of the neural sheath. Gastrointestinal schwannomas are rare among mesenchymal tumors of the gastrointestinal tract, and only a few cases have been reported to date. Duodenal schwannomas are usually discovered incidentally and achieving a preoperative diagnosis is difficult. Schwannomas can be distinguished from other subepithelial tumors on endoscopic ultrasonography; however, any typical endosonographic features of duodenal schwannomas have not been reported due to the rarity of these tumors...
May 15, 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29755092/-two-stage-surgery-for-uterine-intravenous-leiomyomatosis-with-right-ventricular-extension-report-of-a-case
#13
Tomoya Fukui, Koji Kawahito, Akira Sugaya, Keisuke Shimizu, Kei Aizawa, Yoshio Misawa
Intravenous leiomyomatosis is a rare neoplastic condition characterized by the benign intravascular proliferation of smooth muscle cells originating from either the uterine venous wall or a uterine leiomyoma. In the present report, we describe the case of a 36-year-old woman, who was referred to our institution due to abdominal pain. Computed tomography indicated the presence of a giant intravenous leiomyoma originating from the uterus and extending to the right ventricle with complex pathways. The patient was successfully treated by tumor resection under circulatory arrest in two-stage operations in conjunction with gonadotrophin-releasing hormone agonists therapy...
May 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29753325/effects-of-pelvic-endometriosis-and-adenomyosis-on-ciliary-beat-frequency-and-muscular-contractions-in-the-human-fallopian-tube
#14
Wei Xia, Duo Zhang, Jing Ouyang, Yan Liang, Huiyu Zhang, Zhen Huang, Guiling Liang, Qian Zhu, Xiaoming Guan, Jian Zhang
BACKGROUND: Pelvic endometriosis (EM) and adenomyosis (AM) have different effects on the fallopian tube. This study aimed to assess the transport capability of the fallopian tube in women with pelvic EM or AM. METHODS: Twenty women with uterine leiomyoma (control group), 20 with adenomyosis without pelvic EM (AM group) and 35 with pelvic EM without AM (EM group) were included. EM cases were further divided into the tubal EM and non-tubal EM subgroups. Ciliary beat frequency (CBF), percentage of ciliated cells, and smooth muscle contraction were measured...
May 12, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29747655/microrna-21a-5p-overexpression-impacts-mediators-of-extracellular-matrix-formation-in-uterine-leiomyoma
#15
Eden R Cardozo, Rosemary Foster, Anatte E Karmon, Amy E Lee, Leah W Gatune, Bo R Rueda, Aaron K Styer
BACKGROUND: MicroRNAs (MiR) may promote fibroid development via altered expression of genes involved in cell proliferation and ECM formation, and evidence supports aberrant expression of MicroRNA (MiR) 21a-5p in fibroids. The purpose of this study was to investigate the functional significance of MiR 21a-5p overexpression in the pathobiology of leiomyomata (fibroids). METHODS: A basic science experimental design using immortalized fibroid and myometrial cell lines derived from patient-matched specimens was used...
May 11, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29743541/association-of-bet1l-and-tnrc6b-with-uterine-leiomyoma-risk-and-its-relevant-clinical-features-in-han-chinese-population
#16
Bailing Liu, Tao Wang, Jue Jiang, Miao Li, Wenqi Ma, Haibin Wu, Qi Zhou
Previous studies have shown that uterine leiomyomas (UL) are benign tumours with contributions from environmental and genetic factors. We aimed to replicate two initial significant genetic factors, TNRC6B and BET1L, in a Han Chinese population. A total of 2,055 study subjects were recruited, and 55 SNPs mapped to TNRC6B and BET1L were selected and genotyped in samples from these subjects. Genetic associations were analysed at both the single marker and haplotype levels. Associations between targeted SNPs and relevant clinical features of UL were analysed in case only samples...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29742599/the-detection-of-uterine-leiomyoma-fibroid-calcifications-on-18f-naf-pet-ct
#17
Abdullah Al-Zaghal, Thomas J Werner, Poul F Høilund-Carlsen, Abass Alavi
Uterine leiomyomas (fibroids) are the most common type of uterine neoplasms in premenopausal women. Leiomyomas are estrogen dependent and tend to atrophy and shrink in size after menopause. Dystrophic calcification, cystic changes, and necrosis are among the changes that indicate uterine fibroid involution. We are presenting a calcified uterine leiomyoma in a 61-year-old woman as incidentally detected on F-NaF PET/CT scanning. Many previous publications have reported the accumulation of F-NaF in soft tissue calcifications; these findings further set new directions in the evaluation of the metabolic activity of macrocalcification and microcalcification using molecular imaging probes...
May 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29742071/application-of-a-baseball-suture-technique-in-uterine-myomectomy-following-laparoscopic-enucleation-of-uterine-leiomyoma-fibroid
#18
Lingling Xie, Yunyun Liu, Dongyan Wang, Changhao Liu, Hui Zhou, Zhongqiu Lin, Huaiwu Lu
BACKGROUND The aim of this study was to evaluate the safety and efficacy of a 'baseball' suture technique for uterine myomectomy incision closure in laparoscopic surgical enucleation of uterine leiomyoma (fibroid). MATERIAL AND METHODS The study included 20 patients who underwent laparoscopic myomectomy with a 'baseball' suture technique, compared with 20 patients who underwent laparoscopic myomectomy with a standard suture method. Clinical characteristics, perioperative and follow-up data were compared between the two groups...
May 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29741640/rankl-rank-pathway-and-its-inhibitor-rank-fc-in-uterine-leiomyoma-growth
#19
Deborah E Ikhena, Shimeng Liu, Stacy Kujawa, Ecem Esencan, John S Coon, Jared Robins, Serdar E Bulun, Ping Yin
Context: Uterine leiomyomas are the most common type of gynecologic tumor in women. Objective: To determine the role of the cytokine receptor activator of nuclear factor κ-Β ligand (RANKL); its receptor, receptor activator of nuclear factor κ-Β (RANK); and the RANKL/RANK pathway inhibitor RANK-Fc in leiomyoma growth. Design: Messenger RNA (mRNA) or protein levels of RANKL, RANK, and proliferation markers cyclin D1 and Ki67 were assessed in various leiomyoma tissues and cell populations...
May 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29736289/the-rare-togetherness-of-bladder-leiomyoma-and-neurofibromatosis
#20
Cem Yucel, Salih Budak, Erdem Kisa, Orcun Celik, Zafer Kozacioglu
Neurofibromatosis Type 1 (Von Recklinghausen disease) is a common, autosomal dominant hereditary disorder characterized by involvement of multiple tissues derived from the neural crest. Urinary system involvement in neurofibromatosis is a rare condition. Leiomyoma of the bladder is a rare benign mesenchymal tumor. In this case, our experience and approach regarding the bladder leiomyoma development in a patient diagnosed with neurofibromatosis are presented and the literature data has been reviewed.
2018: Case Reports in Urology
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