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Sentinel node in gynecological cancers

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https://www.readbyqxmd.com/read/28533155/indications-and-techniques-for-robotic-pelvic-and-para-aortic-lymphadenectomy-with-sentinel-lymph-node-mapping-in-gynecologic-oncology
#1
REVIEW
Ketura Preya A Wisner, Sarfraz Ahmad, Robert W Holloway
Robotic-assisted laparoscopic surgery is the most common approach for the treatment of early-stage endometrial and cervical cancers in the US. Surgical staging requires pelvic and often aortic lymphadenectomy, depending on the primary tumor characteristics. Pelvic and aortic lymphadenectomy procedures may also be indicated for debulking of larger metastases to improve disease control. The infra-renal basin is an important anatomic site of metastasis from pelvic tumors, and robotic dissection techniques for this site have been described...
April 24, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28441255/european-society-of-gynaecological-oncology-guidelines-for-the-management-of-patients-with-vulvar-cancer
#2
Maaike H M Oonk, François Planchamp, Peter Baldwin, Mariusz Bidzinski, Mats Brännström, Fabio Landoni, Sven Mahner, Umesh Mahantshetty, Mansoor Mirza, Cordula Petersen, Denis Querleu, Sigrid Regauer, Lukas Rob, Roman Rouzier, Elena Ulrikh, Jacobus van der Velden, Ignace Vergote, Linn Woelber, Ate G J van der Zee
OBJECTIVE: The aim of this study was to develop clinically relevant and evidence-based guidelines as part of European Society of Gynaecological Oncology's mission to improve the quality of care for women with gynecologic cancers across Europe. METHODS: The European Society of Gynaecological Oncology Council nominated an international development group made of practicing clinicians who provide care to patients with vulvar cancer and have demonstrated leadership and interest in the management of patients with vulvar cancer (18 experts across Europe)...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28410225/sentinel-lymph-node-mapping-in-endometrial-cancer-a-systematic-review-and-meta-analysis
#3
REVIEW
Hefeng Lin, Zheyuan Ding, Vishnu Goutham Kota, Xiaoming Zhang, Jianwei Zhou
Endometrial cancer is the most frequent tumor in the female reproductive system, while the sentinel lymph node (SLN) mapping for diagnostic efficacy of endometrial cancer is still controversial. This meta-analysis was conducted to evaluate the diagnostic value of SLN in the assessment of lymph nodal involvement in endometrial cancer. Forty-four studies including 2,236 cases were identified. The pooled overall detection rate was 83% (95% CI: 80-86%). The pooled sensitivity was 91% (95% CI: 87-95%). The bilateral pelvic node detection rate was 56% (95% CI: 48-64%)...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28399033/european-society-of-gynaecological-oncology-guidelines-for-the-management-of-patients-with-vulvar-cancer
#4
Maaike H M Oonk, François Planchamp, Peter Baldwin, Mariusz Bidzinski, Mats Brännström, Fabio Landoni, Sven Mahner, Umesh Mahantshetty, Mansoor Mirza, Cordula Petersen, Denis Querleu, Sigrid Regauer, Lukas Rob, Roman Rouzier, Elena Ulrikh, Jacobus van der Velden, Ignace Vergote, Linn Woelber, Ate G J van der Zee
OBJECTIVE: The aim of this study was to develop clinically relevant and evidence-based guidelines as part of European Society of Gynaecological Oncology's mission to improve the quality of care for women with gynecologic cancers across Europe. METHODS: The European Society of Gynaecological Oncology Council nominated an international development group made of practicing clinicians who provide care to patients with vulvar cancer and have demonstrated leadership and interest in the management of patients with vulvar cancer (18 experts across Europe)...
April 8, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28345826/value-of-sentinel-lymph-node-sln-mapping-and-biopsy-using-combined-intracervical-radiotracers-and-blue-dye-injections-for-endometrial-cancer
#5
Farah Farzaneh, Atefeh Moridi, Zahra Azizmohammadi, Mojtaba Ansari J, Maryam Sadat Hosseini, Maliheh Arab, Tahereh Ashrafganjoei, Mina Mazaheri
Background: Lymphadenectomy, as part of the initial surgical staging of patients with endometrial carcinoma, remains a controversial topic in gynecologic oncology. Sentinel lymph node (SLN) mapping has become a well-accepted procedure for melanomas and breast cancer; a number of investigators have begun to explore the utility and accuracy of this technique with regard to endometrial cancer. Aim: This study was conducted to evaluate SLN mapping of early stage endometrial cancer with blue dye in conjunction with a radioactive tracer...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28159465/a-comparison-of-sentinel-lymph-node-biopsy-to-lymphadenectomy-for-endometrial-cancer-staging-fires-trial-a-multicentre-prospective-cohort-study
#6
Emma C Rossi, Lynn D Kowalski, Jennifer Scalici, Leigh Cantrell, Kevin Schuler, Rabbie K Hanna, Michael Method, Melissa Ade, Anastasia Ivanova, John F Boggess
BACKGROUND: Sentinel-lymph-node mapping has been advocated as an alternative staging technique for endometrial cancer. The aim of this study was to measure the sensitivity and negative predictive value of sentinel-lymph-node mapping compared with the gold standard of complete lymphadenectomy in detecting metastatic disease for endometrial cancer. METHODS: In the FIRES multicentre, prospective, cohort study patients with clinical stage 1 endometrial cancer of all histologies and grades undergoing robotic staging were eligible for study inclusion...
March 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28038476/single-site-robotic-radical-hysterectomy-and-sentinel-lymphnode-biopsy-in-cervical-cancer-a-case-report
#7
Alexandre Silva E Silva, Rodrigo Pinto Fernandes, Marcia Pereira de Araujo, João Paulo Mancusi de Carvalho, Filomena Marino Carvalho, Giovani Mastrantônio Favero, Jesus Paula Carvalho
Robotic surgeries for cervical cancer have several advantages compared with laparotomic or laparoscopic surgeries. Robotic single-site surgery has many advantages compared with the multiport approach, but its safety and feasibility are not established in radical oncologic surgeries. We report a case of a Federation of Gynecology and Obstetrics (FIGO) stage IB1 cervical carcinoma whose radical hysterectomy, sentinel lymph node mapping, and lymph node dissection were entirely performed by robotic single-site approach...
January 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28035487/application-of-sentinel-lymph-node-dissection-in-gynecological-cancers-results-of-a-survey-among-german-hospitals
#8
Rüdiger Klapdor, Hermann Hertel, Philipp Soergel, Matthias Jentschke, Peter Hillemanns
PURPOSE: Evaluating the application of the sentinel lymph node dissection (SLND) in gynecological cancers among German hospitals. METHODS: Between March and June 2016 an online questionnaire on SLND in gynecologic cancers was sent by email to all German gynecologic cancer centers, all university hospitals and general hospitals for which an email address was available. The survey contained 61 questions regarding the SLND in vulvar, cervical, endometrial and ovarian cancer...
December 29, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27896515/outcome-after-sentinel-lymph-node-dissection-in-vulvar-cancer-a-subgroup-analysis-of-the-ago-care-1-study
#9
Rüdiger Klapdor, Peter Hillemanns, Linn Wölber, Julia Jückstock, Felix Hilpert, Nikolaus de Gregorio, Severine Iborra, Jalid Sehouli, Anika Habermann, Sophie Teresa Fürst, Hans Georg Strauß, Klaus Baumann, Falk Thiel, Alexander Mustea, Werner Meier, Philipp Harter, Pauline Wimberger, Lars Hanker, Barbara Schmalfeldt, Ulrich Canzler, Tanja Fehm, Alexander Luyten, Martin Hellriegel, Jens Kosse, Christoph Heiss, Peer Hantschmann, Peter Mallmann, Berno Tanner, Jacobus Pfisterer, Barbara Richter, Martin Jäger, Sven Mahner
PURPOSE: Analyzing the large patient cohort of the multicenter AGO-CaRE-1 study, we compared isolated sentinel lymph node dissection (SLND) with radical lymph node dissection (LND) of the groin in relation to recurrence rates and survival. METHODS: The AGO-CaRE-1 study retrospectively collected data on treatment patterns and follow-up of vulvar cancer patients [International Federation of Gynecology and Obstetrics (FIGO) stage ≥1B] treated at 29 gynecologic cancer centers between 1998 and 2008...
November 28, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27882757/-contribution-of-sentinel-lymph-node-biopsy-to-treatment-of-locally-advanced-stages-of-cervical-cancers
#10
J Sláma, M Zikán, D Fischerová, R Kocián, A Germanová, F Frühauf, D Cibula
OBJECTIVE: Usage of sentinel lymph-node (SLN) concept in locally advanced cervical cancers might help to individualise management. According to SLN status could be patients refered to neoadjuvant chemotherapy (NAC) with subsequent surgery or to primary chemoradiation. The aim of our study was to evaluate sensitivity of SLN detection in locally advanced cervical cancers and to assess the impact of NAC on frequency of their metastatic involvement. DESIGN: Retrospective clinical study...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27882746/-technique-of-pelvic-and-paraaortic-lymphadenectomy
#11
J Sláma, R Kocián
OBJECTIVE: Overview of classification, anatomical conditions, methods and complications of pelvic and paraaortic lymph-node dissection. DESIGN: Review article. SETTING: Department of Obstetrics and Gynecology, General Faculty Hospital and 1st Medical Faculty, Charles University, Prague. MATERIALS AND METHODS: Lymphadenectomy is classified according to its extent into sentinel lymph-node biopsy, debulking, sampling and systematic procedure and according to approach into extraperitoneal or transperitoneal procedure...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27815041/feasibility-of-robotic-assisted-laparoendoscopic-single-site-surgery-in-the-gynecologic-oncology-setting
#12
Lea A Moukarzel, Amanda N Fader, Edward J Tanner
STUDY OBJECTIVE: To assess the feasibility of incorporating robotic laparoendoscopic single-site (R-LESS) surgery into gynecologic oncology care. DESIGN: Retrospective study (Canadian Task Force classification II-3). SETTING: Academic university hospital. PATIENTS: Patients undergoing R-LESS hysterectomy for gynecologic malignancies, preinvasive disease, or risk reduction performed by a single gynecologic oncologist between 2014 and 2016...
November 1, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27765958/diagnosis-therapy-and-follow-up-care-of-vulvar-cancer-and-its-precursors-guideline-of-the-dggg-and-dkg-s2k-level-awmf-registry-number-015-059-november-2015
#13
H G Schnürch, S Ackermann, C D Alt, J Barinoff, C Böing, C Dannecker, F Gieseking, A Günthert, P Hantschmann, L C Horn, R Kürzl, P Mallmann, S Marnitz, G Mehlhorn, C C Hack, M C Koch, U Torsten, W Weikel, L Wölber, M Hampl
Purpose: This is an official guideline, published and coordinated by the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO, Study Group for Gynecologic Oncology) of the Deutsche Krebsgesellschaft (DKG, German Cancer Society) and the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe (DGGG, German Society for Gynecology and Obstetrics). The number of cases with vulvar cancer is on the rise, but because of the former rarity of this condition and the resulting lack of literature with a high level of evidence, in many areas knowledge of the optimal clinical management still lags behind what would be required...
October 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27725278/laparoscopic-sentinel-node-mapping-in-endometrial-cancer-after-hysteroscopic-injection-of-indocyanine-green
#14
Fabio Martinelli, Antonino Ditto, Giorgio Bogani, Mauro Signorelli, Valentina Chiappa, Domenica Lorusso, Edward Haeusler, Francesco Raspagliesi
STUDY OBJECTIVE: To report the detection rate (DR) of sentinel lymph nodes (SLNs) in endometrial cancer (EC) patients after hysteroscopic injection of indocyanine green (ICG) and laparoscopic near-infrared (L-NIR) fluorescence mapping. DESIGN: Prospectively collected data (Canadian Task Force classification II-2). SETTING: Gynecologic oncology referral center. PATIENTS: Consecutive patients with apparent early-stage endometrioid EC scheduled for surgical treatment: total laparoscopic hysterectomy, bilateral salpingo-oophorectomy, SLN mapping...
January 1, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27668393/sensitivity-of-follow-up-methods-in-patients-after-fertility-sparing-surgery-for-cervical-cancers
#15
Jiri Slama, Daniela Fischerova, Michal Zikan, Roman Kocian, Anna Germanova, Filip Fruhauf, Ladislav Dusek, David Cibula
OBJECTIVE: The aim of our study was to compare the sensitivity of various methods and their combinations in the follow-up of patients with cervical cancer after fertility-sparing surgery (FSS). METHODS: Included were women with cervical cancer in stages IA2 to IB2 who underwent FSS, which includes pelvic lymphadenectomy, sentinel lymph node biopsy, abdominal radical trachelectomy, vaginal trachelectomy, or needle conization. Follow-up visits were scheduled at 3-month intervals and included symptom-oriented discussion, gynecological and physical examination, colposcopy, Papanicolaou test, human papillomavirus (HPV) DNA test, and ultrasound examination...
January 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27665485/predictors-of-sentinel-lymph-node-metastases-in-breast-cancer-radioactivity-and-ki-67
#16
Fabinshy Thangarajah, Wolfram Malter, Stefanie Hamacher, Matthias Schmidt, Stefan Krämer, Peter Mallmann, Verena Kirn
OBJECTIVES: Since the introduction of the sentinel node technique for breast cancer in the 1990s patient's morbidity was reduced. Tracer uptake is known to be dependent from lymph node integrity and activity of macrophages. The aim of this study was to assess whether radioactivity of the tracer can predict sentinel lymph node metastases. Furthermore, a potential association with Ki-67 index was examined. Non-invasive prediction of lymph node metastases could lead to a further decrease of morbidity...
December 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27643651/utility-of-laparoscopic-indocyanine-green-guided-sentinel-node-biopsy-in-open-cervical-cancer-surgery
#17
Agnieszka Rychlik, Silvia Marin, Javier De Santiago, Ignacio Zapardiel
OBJECTIVE: Multiple tracers have been used to improve lymphatic mapping and to reduce the false-negative rate of the sentinel node detection in gynecologic cancers. Nowadays, 99mTc colloids combined with blue-dye technique is the most extended technique. New alternatives such as the fluorescent indocyanine green and near-infrared fluorescent imaging detection have been introduced in lymphatic mapping staging procedures because of its easier visualization compared with the previous tracers...
September 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27508271/serous-carcinoma-of-endometrium-in-combination-with-neuroendocrine-small-cell-a-case-report-and-literature-review
#18
Lorna A Brudie, Faizan Khan, Michael J Radi, Sarfraz Ahmad
Endometrial serous carcinomas are very clinically aggressive, which constitutes 40% of all deaths and recurrences associated with endometrial cancer. Small-cell carcinoma of the endometrium is relatively rare but aggressive, and often presents a component of endometrioid carcinoma, and is not generally associated with serous carcinoma. Herein, we report a case of 74-year-old African-American female, who presented with intermittent post-menopausal bleeding for > 1-month. She underwent robotic-assisted laparoscopic hysterectomy, bilateral salpingo-oophorectomy, sentinel lymph node mapping, and pelvic-and-aortic lymphadenectomy...
August 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27478163/potential-surgical-and-oncological-consequences-related-to-skin-tattoos-in-the-treatment-of-cervical-cancer
#19
Christhardt Köhler, Tariane Foiato, Simone Marnitz, Achim Schneider, Xin Le, Nasuh Utku Dogan, Tatiana Pfiffer, Anna Elena Jacob, Andrea Mölgg, Ingke Hagemann, Giovanni Favero
STUDY OBJECTIVE: To report the presence of tattoo ink affected pelvic lymph nodes in women with early cervical cancer and to discuss its potential oncological and surgical consequences. DESIGN CLASSIFICATION: Prospective observational study. SETTING: University Hospital in Hamburg, Germany. BACKGROUND: Skin tattoos on the feet, legs, and lower abdominal wall are progressively gaining popularity. Consequently, the number of tattooed women with cervical cancer has significantly increased in the last decade...
July 28, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27230108/beyond-sentinel-node-algorithm-toward-a-more-tailored-surgery-for-cervical-cancer-patients
#20
Anna Fagotti, Luigi Pedone Anchora, Carmine Conte, Vito Chiantera, Enrico Vizza, Lucia Tortorella, Daniela Surico, Pierandrea De Iaco, Giacomo Corrado, Francesco Fanfani, Valerio Gallotta, Giovanni Scambia
Nowadays cervical cancer is frequently diagnosed at early stage. For these patients lymph node metastasis (LNM) is considered the most important prognostic factor. During the last decade many efforts have been made to reduce rate of complications associated with lymphadenectomy (LND). A great interest has arisen in sentinel lymph node (SLN) biopsy as a technique able to decrease number of LND performed and, at the same time, to assess lymph nodal status. High diagnostic performances have been reached thanks to SLN surgical algorithm...
August 2016: Cancer Medicine
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