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Sentinel node in gynecological cancers

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https://www.readbyqxmd.com/read/27896515/outcome-after-sentinel-lymph-node-dissection-in-vulvar-cancer-a-subgroup-analysis-of-the-ago-care-1-study
#1
Rüdiger Klapdor, Peter Hillemanns, Linn Wölber, Julia Jückstock, Felix Hilpert, Nikolaus de Gregorio, Severine Iborra, Jalid Sehouli, Anika Habermann, Sophie Teresa Fürst, Hans Georg Strauß, Klaus Baumann, Falk Thiel, Alexander Mustea, Werner Meier, Philipp Harter, Pauline Wimberger, Lars Hanker, Barbara Schmalfeldt, Ulrich Canzler, Tanja Fehm, Alexander Luyten, Martin Hellriegel, Jens Kosse, Christoph Heiss, Peer Hantschmann, Peter Mallmann, Berno Tanner, Jacobus Pfisterer, Barbara Richter, Martin Jäger, Sven Mahner
PURPOSE: Analyzing the large patient cohort of the multicenter AGO-CaRE-1 study, we compared isolated sentinel lymph node dissection (SLND) with radical lymph node dissection (LND) of the groin in relation to recurrence rates and survival. METHODS: The AGO-CaRE-1 study retrospectively collected data on treatment patterns and follow-up of vulvar cancer patients [International Federation of Gynecology and Obstetrics (FIGO) stage ≥1B] treated at 29 gynecologic cancer centers between 1998 and 2008...
November 28, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27882757/-contribution-of-sentinel-lymph-node-biopsy-to-treatment-of-locally-advanced-stages-of-cervical-cancers
#2
J Sláma, M Zikán, D Fischerová, R Kocián, A Germanová, F Frühauf, D Cibula
OBJECTIVE: Usage of sentinel lymph-node (SLN) concept in locally advanced cervical cancers might help to individualise management. According to SLN status could be patients refered to neoadjuvant chemotherapy (NAC) with subsequent surgery or to primary chemoradiation. The aim of our study was to evaluate sensitivity of SLN detection in locally advanced cervical cancers and to assess the impact of NAC on frequency of their metastatic involvement. DESIGN: Retrospective clinical study...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27882746/-technique-of-pelvic-and-paraaortic-lymphadenectomy
#3
J Sláma, R Kocián
OBJECTIVE: Overview of classification, anatomical conditions, methods and complications of pelvic and paraaortic lymph-node dissection. DESIGN: Review article. SETTING: Department of Obstetrics and Gynecology, General Faculty Hospital and 1st Medical Faculty, Charles University, Prague. MATERIALS AND METHODS: Lymphadenectomy is classified according to its extent into sentinel lymph-node biopsy, debulking, sampling and systematic procedure and according to approach into extraperitoneal or transperitoneal procedure...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27815041/feasibility-of-robotic-assisted-laparoendoscopic-single-site-surgery-in-the-gynecologic-oncology-setting
#4
Lea A Moukarzel, Amanda N Fader, Edward J Tanner
STUDY OBJECTIVE: To assess the feasibility of incorporating robotic laparoendoscopic single-site (R-LESS) surgery into gynecologic oncology care. DESIGN: Retrospective study (Canadian Task Force classification II-3). SETTING: Academic university hospital. PATIENTS: Patients undergoing R-LESS hysterectomy for gynecologic malignancies, preinvasive disease, or risk reduction performed by a single gynecologic oncologist between 2014 and 2016...
November 1, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27765958/diagnosis-therapy-and-follow-up-care-of-vulvar-cancer-and-its-precursors-guideline-of-the-dggg-and-dkg-s2k-level-awmf-registry-number-015-059-november-2015
#5
H G Schnürch, S Ackermann, C D Alt, J Barinoff, C Böing, C Dannecker, F Gieseking, A Günthert, P Hantschmann, L C Horn, R Kürzl, P Mallmann, S Marnitz, G Mehlhorn, C C Hack, M C Koch, U Torsten, W Weikel, L Wölber, M Hampl
Purpose: This is an official guideline, published and coordinated by the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO, Study Group for Gynecologic Oncology) of the Deutsche Krebsgesellschaft (DKG, German Cancer Society) and the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe (DGGG, German Society for Gynecology and Obstetrics). The number of cases with vulvar cancer is on the rise, but because of the former rarity of this condition and the resulting lack of literature with a high level of evidence, in many areas knowledge of the optimal clinical management still lags behind what would be required...
October 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27725278/laparoscopic-sentinel-node-mapping-in-endometrial-cancer-after-hysteroscopic-injection-of-indocyanine-green
#6
Fabio Martinelli, Antonino Ditto, Giorgio Bogani, Mauro Signorelli, Valentina Chiappa, Domenica Lorusso, Edward Haeusler, Francesco Raspagliesi
STUDY OBJECTIVE: To report the detection rate (DR) of sentinel lymph nodes (SLNs) in endometrial cancer (EC) patients after hysteroscopic injection of indocyanine green (ICG) and laparoscopic near-infrared (L-NIR) fluorescence mapping. DESIGN: Prospectively collected data (Canadian Task Force classification II-2). SETTING: Gynecologic oncology referral center. PATIENTS: Consecutive patients with apparent early-stage endometrioid EC scheduled for surgical treatment: total laparoscopic hysterectomy, bilateral salpingo-oophorectomy, SLN mapping...
October 8, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27668393/sensitivity-of-follow-up-methods-in-patients-after-fertility-sparing-surgery-for-cervical-cancers
#7
Jiri Slama, Daniela Fischerova, Michal Zikan, Roman Kocian, Anna Germanova, Filip Fruhauf, Ladislav Dusek, David Cibula
OBJECTIVE: The aim of our study was to compare the sensitivity of various methods and their combinations in the follow-up of patients with cervical cancer after fertility-sparing surgery (FSS). METHODS: Included were women with cervical cancer in stages IA2 to IB2 who underwent FSS, which includes pelvic lymphadenectomy, sentinel lymph node biopsy, abdominal radical trachelectomy, vaginal trachelectomy, or needle conization. Follow-up visits were scheduled at 3-month intervals and included symptom-oriented discussion, gynecological and physical examination, colposcopy, Papanicolaou test, human papillomavirus (HPV) DNA test, and ultrasound examination...
September 23, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27665485/predictors-of-sentinel-lymph-node-metastases-in-breast-cancer-radioactivity-and-ki-67
#8
Fabinshy Thangarajah, Wolfram Malter, Stefanie Hamacher, Matthias Schmidt, Stefan Krämer, Peter Mallmann, Verena Kirn
OBJECTIVES: Since the introduction of the sentinel node technique for breast cancer in the 1990s patient's morbidity was reduced. Tracer uptake is known to be dependent from lymph node integrity and activity of macrophages. The aim of this study was to assess whether radioactivity of the tracer can predict sentinel lymph node metastases. Furthermore, a potential association with Ki-67 index was examined. Non-invasive prediction of lymph node metastases could lead to a further decrease of morbidity...
December 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27643651/utility-of-laparoscopic-indocyanine-green-guided-sentinel-node-biopsy-in-open-cervical-cancer-surgery
#9
Agnieszka Rychlik, Silvia Marin, Javier De Santiago, Ignacio Zapardiel
OBJECTIVE: Multiple tracers have been used to improve lymphatic mapping and to reduce the false-negative rate of the sentinel node detection in gynecologic cancers. Nowadays, 99mTc colloids combined with blue-dye technique is the most extended technique. New alternatives such as the fluorescent indocyanine green and near-infrared fluorescent imaging detection have been introduced in lymphatic mapping staging procedures because of its easier visualization compared with the previous tracers...
September 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27508271/serous-carcinoma-of-endometrium-in-combination-with-neuroendocrine-small-cell-a-case-report-and-literature-review
#10
Lorna A Brudie, Faizan Khan, Michael J Radi, Sarfraz Ahmad
Endometrial serous carcinomas are very clinically aggressive, which constitutes 40% of all deaths and recurrences associated with endometrial cancer. Small-cell carcinoma of the endometrium is relatively rare but aggressive, and often presents a component of endometrioid carcinoma, and is not generally associated with serous carcinoma. Herein, we report a case of 74-year-old African-American female, who presented with intermittent post-menopausal bleeding for > 1-month. She underwent robotic-assisted laparoscopic hysterectomy, bilateral salpingo-oophorectomy, sentinel lymph node mapping, and pelvic-and-aortic lymphadenectomy...
August 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27478163/potential-surgical-and-oncological-consequences-related-to-skin-tattoos-in-the-treatment-of-cervical-cancer
#11
Christhardt Köhler, Tariane Foiato, Simone Marnitz, Achim Schneider, Xin Le, Nasuh Utku Dogan, Tatiana Pfiffer, Anna Elena Jacob, Andrea Mölgg, Ingke Hagemann, Giovanni Favero
STUDY OBJECTIVE: To report the presence of tattoo ink affected pelvic lymph nodes in women with early cervical cancer and to discuss its potential oncological and surgical consequences. DESIGN CLASSIFICATION: Prospective observational study. SETTING: University Hospital in Hamburg, Germany. BACKGROUND: Skin tattoos on the feet, legs, and lower abdominal wall are progressively gaining popularity. Consequently, the number of tattooed women with cervical cancer has significantly increased in the last decade...
July 28, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27230108/beyond-sentinel-node-algorithm-toward-a-more-tailored-surgery-for-cervical-cancer-patients
#12
Anna Fagotti, Luigi Pedone Anchora, Carmine Conte, Vito Chiantera, Enrico Vizza, Lucia Tortorella, Daniela Surico, Pierandrea De Iaco, Giacomo Corrado, Francesco Fanfani, Valerio Gallotta, Giovanni Scambia
Nowadays cervical cancer is frequently diagnosed at early stage. For these patients lymph node metastasis (LNM) is considered the most important prognostic factor. During the last decade many efforts have been made to reduce rate of complications associated with lymphadenectomy (LND). A great interest has arisen in sentinel lymph node (SLN) biopsy as a technique able to decrease number of LND performed and, at the same time, to assess lymph nodal status. High diagnostic performances have been reached thanks to SLN surgical algorithm...
August 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27226506/new-nccn-guidelines-for-vulvar-cancer
#13
Benjamin E Greer, Wui-Jin Koh
For the first time, NCCN Guidelines are available for vulvar cancer, a rare gynecologic cancer. Early-stage cancers can be managed by surgery and observation, and many of these patients can be cured. Lymph node status drives treatment and correlates with survival. Positive groinal nodes require additional therapy, including radiation plus chemotherapy, depending on stage. Sentinel lymph node biopsy is recommended in selected patients.
May 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27102250/incidence-of-metastasis-in-circumflex-iliac-nodes-distal-to-the-external-iliac-nodes-in-cervical-cancer
#14
Sho Takeshita, Yukiharu Todo, Kazuhira Okamoto, Satoko Sudo, Katsushige Yamashiro, Hidenori Kato
OBJECTIVE: A causal relationship between removal of circumflex iliac nodes distal to the external iliac nodes (CINDEIN) and lower leg edema has been recently suggested. The aim of this study was to elucidate the incidence of CINDEIN metastasis in cervical cancer. METHODS: A retrospective chart review was carried out for 531 patients with cervical cancer who underwent lymph node dissection between 1993 and 2014. CINDEIN metastasis was pathologically identified by microscopic investigation...
July 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/26961924/sentinel-lymph-node-mapping-in-endometrial-cancer-an-update
#15
Fady Khoury-Collado, Caryn St Clair, Nadeem R Abu-Rustum
UNLABELLED: : Lymph node removal for staging, as part of the initial surgical management of patients with endometrial carcinoma, remains a controversial topic in gynecologic oncology. There is currently wide variability among clinical practices, with surgical approaches ranging from no nodal evaluation to comprehensive pelvic and aortic lymphadenectomy. Lymphatic mapping has emerged as an increasingly popular option over the past few years, with several attractive features in its concept, innovative surgical approach, and encouraging preliminary results...
April 2016: Oncologist
https://www.readbyqxmd.com/read/26921484/near-infrared-sentinel-lymph-node-mapping-with-indocyanine-green-using-the-vitom-ii-icg-exoscope-for-open-surgery-for-gynecologic-malignancies
#16
Alessandro Buda, Tiziana Dell'Anna, Francesca Vecchione, Debora Verri, Giampaolo Di Martino, Rodolfo Milani
Sentinel lymph node (SLN) mapping is emerging as an effective method for surgical staging of different gynecologic malignancies. Near-infrared (NIR) technology using a fluorescent dye such as indocyanine green (ICG) represents an interesting and feasible method for SLN mapping even in traditional open surgeries by applying video telescope operating microscope (VITOM) system technology. We report our preliminary experience in 12 women who underwent surgical nodal staging for early-stage vulvar and uterine or cervical cancer...
May 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/26841164/cervical-cancer-what-s-new
#17
REVIEW
José Carlos Sadalla, Jurandyr Moreira de Andrade, Maria Luiza Nogueira Dias Genta, Edmund Chada Baracat
Cervical cancer is the most common gynecological cancer in Brazil. Among women, it is the second most frequent, second only to breast cancer. It is the fourth leading cause of cancer death in the country, with estimated 15,590 new cases (2014) and 5,430 deaths (2013). In order to update information to improve outcomes, reduce morbidity and optimize the treatment of this cancer, this article will address the advancement of knowledge on cervical cancer. The topics covered include the role of surgery in different stages, treatment of locally advanced carcinomas, fertility preservation, the role of the sentinel lymph node technique, indications and techniques of radiotherapy and chemotherapy, and some special situations...
November 2015: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/26807636/high-incidence-of-erysipelas-after-surgical-treatment-for-vulvar-carcinoma-an-observational-study
#18
Maria E J Leermakers, Noortje Pleunis, Dorry Boll, Ralph H Hermans, Nicole P M Ezendam, Johanna M A Pijnenborg
OBJECTIVES: Vulvar carcinoma is mainly treated surgically and has an overall good prognosis. Despite the development of minimally invasive surgical procedures in recent years, morbidity remains significant. The aim of the study was to determine the incidence and risk factors of erysipelas after surgical treatment for vulvar carcinoma. METHODS: This retrospective observational study was performed within the Comprehensive Cancer Centre South. The study included patients (N = 116) who underwent surgery for primary vulvar carcinoma between 2005 and 2012...
March 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/26711830/-meta-analysis-of-application-value-of-sentinel-lymph-node-biopsy-in-early-stage-vulval-squamous-cell-carcinoma
#19
Hua Tu, He Huang, Jihong Liu
OBJECTIVE: To systematically review the clinical value of sentinel lymph node biopsy (SLNB) in diagnosis of lymph node metastasis in early-stage squamous cell carcinoma of vulva. METHODS: Cochrane library, biomedical database (EMbase), PubMed, China national knowledge internet (CNKI), Wang Fang database, «Gynecologic Oncology», «National Medical Journal of China» and «Chinese Journal of Obstetrics and Gynecology» were searched for literatures from 1990 to 2014 concerning SLNB application in early-stage vulvar squamous cell carcinoma...
September 1, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26646959/-increasingly-better-diagnosis-and-treatment-of-endometrial-cancer
#20
REVIEW
Sahar Salehi, Karin Stålberg, Janusz Marcickiewicz, Per Rosenberg, Henrik Falconer
Endometrial cancer is the most common gynecological cancer in developed countries and the observed rise in incidence is mainly caused by life style factors including obesity and diabetes. The management of the disease has undergone major changes in the past 5-10 years. Morphological and genetic studies constitute the basis for the new classification of the disease, and data emerging from the Cancer Genome Atlas suggest that genomic patterns differ within the two types of endometrial cancer. The prognosis seems to be related to occult lymphatic spread but the role of lymphadenectomy is heavily debated...
2015: Läkartidningen
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