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https://www.readbyqxmd.com/read/29457151/the-impact-of-igg-transplacental-transfer-on-early-life-immunity
#1
Genevieve G Fouda, David R Martinez, Geeta K Swamy, Sallie R Permar
Pediatric vaccines have significantly reduced infectious disease-related infant mortality, but as protective immunity often require several infant vaccine doses; maternally-acquired antibodies are critical to protect infants during the first months of life. Consequently, immunization of pregnant women is an important strategy not only to protect mothers from infection, but also to provide immunity to young infants. Nevertheless, maternal immunization can also negatively impact early life immunity. In fact, maternal antibodies can interfere with the development of infant immune responses, though it is unclear if such interference is clinically significant...
January 1, 2018: ImmunoHorizons
https://www.readbyqxmd.com/read/29437046/zika-and-public-health-understanding-the-epidemiology-and-information-environment
#2
Pia D M MacDonald, E Wayne Holden
Because Zika is a newly emerging infectious disease with little previous information known about it, there are many epidemiologic and clinical questions. The complexity of providing care to those who are at risk for infection or are already infected with Zika in this evidence-scarce environment cannot be understated. In this article, we provide an overview of the Zika virus (ZIKV) in the context of public health and pediatric health care. A broad public health focus is used to provide relevant information for addressing important questions about the epidemic and to facilitate communication with patients, parents, and caregivers within the current information environment...
February 2018: Pediatrics
https://www.readbyqxmd.com/read/29428589/infectious-pathogens-meet-point-of-care-diagnostics
#3
REVIEW
Mohammad Zarei
The field of point-of-care (POC) diagnostics provides the rapid diagnosis of infectious diseases which is essential and critical for improving the general public health in resource-limited settings. POC platforms offer many advantages for detection of various pathogens including portability, automation, speed, cost, and efficiency. In this review, we provide an overview of the recent trends for POC diagnostics of infectious diseases with focus on portable platforms. We review here the present status of POC platforms, emphasizing in period of the past three years, then extrapolate their advance into the future applications for diagnosis of infectious pathogens...
February 3, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29406956/diagnosis-and-treatment-of-catheter-related-bloodstream-infection-clinical-guidelines-of-the-spanish-society-of-infectious-diseases-and-clinical-microbiology-and-seimc-and-the-spanish-society-of-spanish-society-of-intensive-and-critical-care-medicine-and-coronary
#4
F Chaves, J Garnacho-Montero, J L Del Pozo, E Bouza, J A Capdevila, M de Cueto, M Á Domínguez, J Esteban, N Fernández-Hidalgo, M Fernández Sampedro, J Fortún, M Guembe, L Lorente, J R Paño, P Ramírez, M Salavert, M Sánchez, J Vallés
Catheter-related bloodstream infections (CRBSI) constitute an important cause of hospital-acquired infection associated with morbidity, mortality, and cost. The aim of these guidelines is to provide updated recommendations for the diagnosis and management of CRBSI in adults. Prevention of CRBSI is excluded. Experts in the field were designated by the two participating Societies (the Spanish Society of Infectious Diseases and Clinical Microbiology and [SEIMC] and the Spanish Society of Spanish Society of Intensive and Critical Care Medicine and Coronary Units [SEMICYUC])...
January 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29393841/the-infectious-disease-network-idn-development-and-use-for-evaluation-of-potential-ebola-cases-in-georgia
#5
Alezandria K Turner, Robert K Wages, Kelly Nadeau, Laura Edison, Peki F Prince, Earnest R Doss, Cherie Drenzek, Patrick O'Neal
In response to the 2014 Ebola virus disease (EVD) outbreak in West Africa, the Georgia Department of Public Health developed the Infectious Disease Network (IDN) based on an EVD preparedness needs assessment of hospitals and Emergency Medical Services (EMS) providers. The network consists of 12 hospitals and 16 EMS providers with staff specially trained to provide a coordinated response and utilize appropriate personal protective equipment (PPE) for the transport or treatment of a suspected or confirmed serious communicable disease patient...
February 2, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29378581/patient-and-provider-perspectives-inform-an-intervention-to-improve-linkage-to-care-for-hiv-patients-in-ukraine
#6
Tetiana Kiriazova, Oleksandr Postnov, Trista Bingham, Janet Myers, Timothy Flanigan, Charles Vitek, Oleksandr Neduzhko
BACKGROUND: Engagement with HIV medical care is critical to successful HIV treatment and prevention efforts. However, in Ukraine, delays in the timely initiation of HIV treatment hamper viral suppression. By January 01, 2016, only 126,604 (57.5%) of the estimated 220,000 people living with HIV (PLWH) had registered for HIV care, and most (55.1%) of those who registered for HIV care in 2015 did that at a late stage of infection. In the US, Anti-Retroviral Treatment and Access to Services (ARTAS) intervention successfully linked newly diagnosed PLWH to HIV services using strengths-based case management with a linkage coordinator...
January 30, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29352835/a-gap-analysis-survey-of-us-aircraft-rescue-and-fire-fighting-arff-members-to-determine-highly-infectious-disease-training-and-education-needs
#7
Aurora B Le, Rene Herron, Jocelyn J Herstein, Katelyn C Jelden, Elizabeth L Beam, Shawn G Gibbs, John J Lowe, Todd D Smith
OBJECTIVE: Despite lessons learned from the recent Ebola epidemic, attempts to survey and determine non-health care worker, industry-specific needs to address highly infectious diseases have been minimal. The aircraft rescue and fire fighting (ARFF) industry is often overlooked in highly infectious disease training and education, even though it is critical to their field due to elevated occupational exposure risk during their operations. METHODS: A 44-question gap analysis survey was distributed to the ARFF Working Group to determine where highly infectious education and training can be improved...
January 21, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29324838/canine-visceral-leishmaniasis-diagnosis-and-management-of-the-reservoir-living-among-us
#8
REVIEW
Bruno L Travi, Anabela Cordeiro-da-Silva, Filipe Dantas-Torres, Guadalupe Miró
This article reviews essential topics of canine visceral leishmaniasis (CVL) due to Leishmania infantum infection. It focuses on the current serological and molecular diagnostic methods used in epidemiological research and veterinary clinics to diagnose CVL and includes new point-of-care (POC) tests under development. The efficacy of different treatment regimens on the clinical improvement and infectiousness of dogs is also addressed. In the last section, the review provides a critical appraisal of the effectiveness of different control measures that have been implemented to curb disease transmission...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29305954/clinical-use-of-the-polymyxins-the-tale-of-the-fox-and-the-cat
#9
Eric Wenzler, Kristen L Bunnell, Larry H Danziger
BACKGROUND: There is a need to identify practice patterns of polymyxin use, quantify gaps in knowledge, and recognize areas of persistent confusion. METHODS: A structured electronic survey was distributed to physicians, pharmacists, and microbiologists. Demographic information was obtained along with data regarding the availability, stewardship principles, therapeutic usage, dosing, microbiological testing, and knowledge, attitudes, and beliefs regarding the polymyxins...
January 3, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29304840/factors-influencing-adherence-to-tuberculosis-treatment-in-asmara-eritrea-a-qualitative-study
#10
Frezghi Hidray Gebreweld, Meron Mehari Kifle, Fitusm Eyob Gebremicheal, Leban Lebahati Simel, Meron Mebrahtu Gezae, Shewit Sibhatu Ghebreyesus, Yordanos Tesfamariam Mengsteab, Nebiat Ghirmay Wahd
BACKGROUND: Non-adherence to tuberculosis (TB) treatment is an important barrier for TB prevention and control. Poor adherence may result in prolonged disease infectiousness, drug resistance, relapse and death. The aim of this study was to assess factors influencing adherence to tuberculosis treatment in selected health facilities in Asmara, Eritrea. METHODS: A qualitative study which included in-depth interviews with 12 TB patients, three focus group discussions in selected health facilities in which one group comprised eight patients and key informant interviews with three health workers...
January 5, 2018: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29298792/lemierre-s-syndrome-a-pain-in-the-neck-with-far-reaching-consequences
#11
Thomas James Stubington, Paul James
Lemierre's syndrome is a potentially life-threatening consequence of oropharyngeal and ear infections and often results in critical care admission and even intubation. Due to the multisystem manifestation, multiple teams may initially be involved in the care, some of which may be unfamiliar with the features and usual clinical course. This report describes a case in a 36-year-old woman with the classic features of internal jugular vein thrombosis and septic emboli to the lungs secondary to an oropharyngeal infection...
January 3, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29295496/roles-of-heat-shock-proteins-in-apoptosis-oxidative-stress-human-inflammatory-diseases-and-cancer
#12
REVIEW
Paul Chukwudi Ikwegbue, Priscilla Masamba, Babatunji Emmanuel Oyinloye, Abidemi Paul Kappo
Heat shock proteins (HSPs) play cytoprotective activities under pathological conditions through the initiation of protein folding, repair, refolding of misfolded peptides, and possible degradation of irreparable proteins. Excessive apoptosis, resulting from increased reactive oxygen species (ROS) cellular levels and subsequent amplified inflammatory reactions, is well known in the pathogenesis and progression of several human inflammatory diseases (HIDs) and cancer. Under normal physiological conditions, ROS levels and inflammatory reactions are kept in check for the cellular benefits of fighting off infectious agents through antioxidant mechanisms; however, this balance can be disrupted under pathological conditions, thus leading to oxidative stress and massive cellular destruction...
December 23, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29288367/antimicrobial-resistance-and-antibiotic-stewardship-programs-in-the-icu-insistence-and-persistence-in-the-fight-against-resistance-a-position-statement-from-esicm-escmid-waaar-round-table-on-multi-drug-resistance
#13
Jan J De Waele, Murat Akova, Massimo Antonelli, Rafael Canton, Jean Carlet, Daniel De Backer, George Dimopoulos, José Garnacho-Montero, Jozef Kesecioglu, Jeffrey Lipman, Mervyn Mer, José-Artur Paiva, Mario Poljak, Jason A Roberts, Jesus Rodriguez Bano, Jean-François Timsit, Jean-Ralph Zahar, Matteo Bassetti
Antimicrobial resistance (AMR) is a clear and present danger to patients in any intensive care unit (ICU) around the world. Whereas AMR may affect any patient in the hospital, patients in the ICU are particularly at risk of acquiring AMR infections due to the intensity of the treatment, use of invasive devices, increased risk of transmission and exposure to antibiotics. AMR is present in every ICU, although prevalence is geographically different and AMR pathogens encountered are variable. Intensive care and infectious disease specialists from the European Society of Intensive Care Medicine, European Society of Microbiology and Infectious Diseases and World Alliance Against Antimicrobial Resistance, united in the ANTARCTICA (Antimicrobial Resistance in Critical Care) coalition, call for increased awareness and action among health care professionals to reduce AMR development in critically ill patients, to improve treatment of AMR infections and to coordinate scientific research in this high-risk patient population...
December 29, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29249609/lessons-from-the-domestic-ebola-response-improving-health-care-system-resilience-to-high-consequence-infectious-diseases
#14
Diane Meyer, Tara Kirk Sell, Monica Schoch-Spana, Matthew P Shearer, Hannah Chandler, Erin Thomas, Dale A Rose, Eric G Carbone, Eric Toner
BACKGROUND: The domestic response to the West Africa Ebola virus disease (EVD) epidemic from 2014-2016 provides a unique opportunity to distill lessons learned about health sector planning and operations from those individuals directly involved. This research project aimed to identify and integrate these lessons into an actionable checklist that can improve health sector resilience to future high-consequence infectious disease (HCID) events. METHODS: Interviews (N = 73) were completed with individuals involved in the domestic EVD response in 4 cities (Atlanta, Dallas, New York, and Omaha), and included individuals who worked in academia, emergency management, government, health care, law, media, and public health during the response...
December 15, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29234378/antibiofilm-and-anti-inflammatory-activities-of-houttuynia-cordata-decoction-for-oral-care
#15
Yasuko Sekita, Keiji Murakami, Hiromichi Yumoto, Kouji Hirao, Takashi Amoh, Natsumi Fujiwara, Katsuhiko Hirota, Hideki Fujii, Takashi Matsuo, Yoichiro Miyake, Yoshiki Kashiwada
Dental biofilms that form in the oral cavity play a critical role in the pathogenesis of several infectious oral diseases, including dental caries, periodontal disease, and oral candidiasis. Houttuynia cordata (HC, Saururaceae) is a widely used traditional medicine, for both internal and external application. A decoction of dried HC leaves (dHC) has long been consumed as a health-promoting herbal tea in Japan. We have recently reported that a water solution of HC poultice ethanol extract (wHCP) exerts antimicrobial and antibiofilm effects against several important oral pathogens...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29230523/adjuvant-therapies-in-critical-care-steroids-to-treat-infectious-diseases
#16
José Manuel Pereira, Thiago Lisboa, José-Artur Paiva
No abstract text is available yet for this article.
December 11, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29211187/the-epimed-monitor-icu-database%C3%A2-a-cloud-based-national-registry-for-adult-intensive-care-unit-patients-in-brazil
#17
Fernando Godinho Zampieri, Márcio Soares, Lunna Perdigão Borges, Jorge Ibrain Figueira Salluh, Otávio Tavares Ranzani
OBJECTIVE: To describe the Epimed Monitor Database®, a Brazilian intensive care unit quality improvement database. METHODS: We described the Epimed Monitor® Database, including its structure and core data. We presented aggregated informative data from intensive care unit admissions from 2010 to 2016 using descriptive statistics. We also described the expansion and growth of the database along with the geographical distribution of participating units in Brazil...
November 30, 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29204328/the-role-of-affordable-point-of-care-technologies-for-cancer-care-in-low-and-middle-income-countries-a-review-and-commentary
#18
Karen Haney, Pushpa Tandon, Rao Divi, Miguel R Ossandon, Houston Baker, Paul C Pearlman
As the burden of non-communicable diseases such as cancer continues to rise in low- and middle-income countries (LMICs), it is essential to identify and invest in promising solutions for cancer control and treatment. Point-of-care technologies (POCTs) have played critical roles in curbing infectious disease epidemics in both high- and low-income settings, and their successes can serve as a model for transforming cancer care in LMICs, where access to traditional clinical resources is often limited. The versatility, cost-effectiveness, and simplicity of POCTs warrant attention for their potential to revolutionize cancer detection, diagnosis, and treatment...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29199253/-effects-of-pharmacist-intervention-on-the-treatment-of-infectious-diseases-in-critically-ill-patients
#19
Masaharu Imaura
 The pathological conditions of patients who require intensive care are usually complex and extremely severe; their health and life are in a critical state. Therefore, correct, rapid treatment of these conditions is indispensable. Furthermore, the selection of drugs and adjustment of their dosage for an immediate effect are important. Moreover, most patients are immunocompromised and present an extremely high level of risk for complications involving infectious diseases. Since such complications may lead to life-threatening outcomes, a rational dosage regimen to achieve sufficient antimicrobial activity from the initial stage of treatment is essential...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29157660/encephalitis-and-myelitis-in-tropical-countries-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#20
REVIEW
Gisele Sampaio Silva, Guy A Richards, Tim Baker, Pravin R Amin
Tropical diseases are those that occur primarily or solely in the tropics, and as such include infectious diseases that are particularly prevalent in hot, humid conditions. The incidence of encephalitis in tropical countries is reported to be as high as 6.34/100,000/year. The term encephalitis implies inflammation of the brain and includes the presence of encephalopathy with two and more of the following features: fever, seizures and/or focal neurological findings; a cerebrospinal fluid pleocytosis; electroencephalographic findings or abnormal neuroimaging suggestive of encephalitis...
November 3, 2017: Journal of Critical Care
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