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JOURNAL ARTICLE
Joy Melnikow, Andrew Padovani, Jingwen Zhang, Marykate Miller, Melissa Gosdin, Sabrina Loureiro, Brock Daniels
OBJECTIVE: COVID-19 vaccination is critical for reducing serious illness and hospitalizations, yet many remain hesitant. We conducted a survey of frontline physicians to identify patient concerns and physician strategies to address COVID-19 vaccine-hesitancy. METHODS: A national random sample of physicians in frontline specialties selected from a comprehensive list of practicing physicians in the U.S. were emailed a survey in August 2021. Multiple choice and open-ended questions inquired about patient concerns related to the COVID-19 vaccines and strategies used by physicians to counter vaccine misinformation and encourage vaccine-hesitant patients...
April 15, 2024: Vaccine
#2
JOURNAL ARTICLE
Guillaume Geslain, Aurélie Cointe, Jérôme Naudin, Stéphane Dauger, Nora Poey, Justine Pages, Enora Le Roux, Stéphane Bonacorsi
BACKGROUND: Community-acquired and nosocomial lower-respiratory-tract infections in critically ill pediatric patients require early appropriate antibiotic therapy to optimize outcomes. Using blind bronchial samples, we assessed the diagnostic performance of the rapid-multiplex polymerase chain reaction (PCR) assay BioFire Pneumonia plus Panel vs. reference standard culturing with antimicrobial susceptibility testing. METHODS: For this prospective observational study in a single pediatric intensive care unit, we included consecutive patients younger than 18 years admitted for suspected community-, hospital- or ventilator-associated pneumonia in 2021-2022...
April 8, 2024: Pediatric Infectious Disease Journal
#3
JOURNAL ARTICLE
Seval Özen, Saliha Kanik Yüksek, Bedia Dinç, Fatih Üçkardeş, Hatice Kübra Konca, Tuğba Erat, Ahmet Yasin Güney, Ömer Güneş, Zehra Nihan Coşkun, Belgin Gülhan, Gülsüm İclal Bayhan, Nilay Çöplü, Asli Nur Özkaya Parlakay, Namik Yaşar Özbek
BACKGROUND: Herbaspirillum species are nonfermenting, aerobic, helical or curved, Gram-negative bacteria belonging to the class Betaproteobacteria, order Burkholderiales. To date, only a few studies have reported on the epidemiology, clinical symptoms, antibiotic susceptibility profiles, treatment and outcomes of Herbaspirillum huttiense-related infections in pediatric patients. METHODS: The aim of this study was to present 3 years of H.Huntiense data, antibiotic susceptibility profiles, systemic antibiotics and antibiotic lock therapy (ALT) options and clinical outcomes...
April 8, 2024: Pediatric Infectious Disease Journal
#4
REVIEW
Nabil Shallik, Khalid Bashir, Amr Elmoheen, Haris Iftikhar, Hany A Zaki
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2, which was first discovered in Wuhan, China. The disease has grown into a global pandemic causing mild to moderate symptoms in most people. The disease can also exhibit serious illnesses, especially for patients with other chronic diseases such as cardiovascular diseases, diabetes, chronic respiratory disease, or cancer. In such cases of severe illness, high flow nasal oxygen (HFNO) has been used to provide oxygenation to COVID-19 patients...
June 2023: Trends in Anaesthesia & Critical Care
#5
JOURNAL ARTICLE
Muttiah Barathan
Acute Undifferentiated Febrile Illness (AUFI) presents a clinical challenge, often characterized by sudden fever, non-specific symptoms, and potential life-threatening implications. This review highlights the global prevalence, types, challenges, and implications of AUFI, especially in tropical and subtropical regions where infectious diseases thrive. It delves into the difficulties in diagnosis, prevalence rates, regional variations, and potential causes, ranging from bacterial and viral infections to zoonotic diseases...
April 13, 2024: Pathogens and Disease
#6
JOURNAL ARTICLE
Stuart Campbell, Simon Smith, Josh Hanson
Existing recommended first-line antibiotic agents for MRSA pneumonia have several shortcomings. We reviewed 29 cases of community- and hospital-acquired MRSA pneumonia managed at our hospital. Lincosamide monotherapy was administered to 21/29 (72%) and was the predominant antibiotic regimen (> 50% course duration) in 19/29 (66%). Patients receiving lincosamide-predominant monotherapy were no more likely to die or require intensive care unit admission than patients receiving vancomycin-predominant monotherapy (5/19 (26%) versus 4/7 (57%), p = 0...
April 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
#7
JOURNAL ARTICLE
Brennan Collis, Christina Guo, Chris C Lee, Sadid F Khan
No abstract text is available yet for this article.
April 10, 2024: Clinical Infectious Diseases
#8
Niccolò Buetti, Alexis Tabah, Nour Setti, Stéphane Ruckly, François Barbier, Murat Akova, Abdullah Tarik Aslan, Marc Leone, Matteo Bassetti, Andrew Conway Morris, Kostoula Arvaniti, José-Artur Paiva, Ricard Ferrer, Haibo Qiu, Giorgia Montrucchio, Andrea Cortegiani, Bircan Kayaaslan, Liesbet De Bus, Jan J De Waele, Jean-François Timsit
No abstract text is available yet for this article.
April 8, 2024: Intensive Care Medicine
#9
Allorie T Caldwell, Toni Gabaldón, Verónica Mixão, Nancy L Wengenack, Benjamin P Westley, Ryan W Stevens
Fungemia is common in critically-ill patient populations, and is associated with a high rate of mortality, especially when caused by non-albicans Candida species. Herein, we describe a fatal case of fungemia following cardiothoracic surgery in which the organism, initially identified as Candida inconspicua, represents a novel species: Pichia alaskaensis.
April 3, 2024: International Journal of Infectious Diseases: IJID
#10
JOURNAL ARTICLE
Julio C Zuniga-Moya, Benjamin Papadopoulos, Armaghan-E-Rehman Mansoor, Patrick B Mazi, Adriana M Rauseo, Andrej Spec
BACKGROUND: An association between coronavirus disease 2019 (COVID-19)-associated invasive fungal infections (CAIFIs) and high mortality among intubated patients has been suggested in previous research. However, some of the current evidence was derived from small case series and multicenter studies conducted during different waves of the COVID-19 pandemic. We examined the incidence of CAIFIs and their associated mortality using a large, multicenter COVID-19 database built throughout the pandemic...
April 2024: Open Forum Infectious Diseases
#11
Maureen J Miller, Patricia Lee, Brian G Lee, Willy A Flegel, Kamille West-Mitchell, Kathleen Conry-Cantilena, Valeria De Giorgi
BACKGROUND: The U.S. Centers for Disease Control and Prevention (CDC) has reported increasing rates of alpha-gal syndrome, an allergic response after meat ingestion (AGS). AGS has been associated with prior exposure to tick bites or other biologics characterized by a life-threatening immunoglobulin E (IgE)-mediated hypersensitivity to galactose-alpha-1,3-galactose (alpha-gal) an oligosaccharide structurally similar to the group B antigen on red blood cells (RBC) found in most non-primate mammalian meat and products derived from these mammals...
April 3, 2024: Transfusion
#12
JOURNAL ARTICLE
Kyung-Shin Lee, Changwoo Han, Hye Sook Min, Jeehye Lee, Seok Hwa Youn, Younghwan Kim, Jae Young Moon, Young Seok Lee, Su Jin Kim, Ho Kyung Sung
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic resulted in significant disruptions to critical care systems globally. However, research on the impact of the COVID-19 pandemic on intensive care unit (ICU) admissions via the emergency department (ED) is limited. Therefore, this study evaluated the changes in the number of ED-to-ICU admissions and clinical outcomes in the periods before and during the pandemic. METHODS: We identified all adult patients admitted to the ICU through level 1 or 2 EDs in Korea between February 2018 and January 2021...
April 1, 2024: BMC Emergency Medicine
#13
JOURNAL ARTICLE
Marta Albanell-Fernández, Fernando Salazar González, Olalla Montero Pérez, Victoria Aniyar, Francisco-Javier Carrera Hueso, Alex Soriano, Carolina García-Vidal, Pedro Puerta-Alcalde, José Antonio Martínez, Pedro Vázquez Ferreiro
OBJECTIVE: De-escalation (DES) from echinocandins to azoles is recommended by several medical societies in Candida infections. We summarize the evidence of DES on clinical and microbiological cure and 30-day survival and compare it with continuing the treatment with echinocandins (Non-DES). METHODS: We searched MEDLINE, Embase, Web of Science, Scopus. Studies describing DES in inpatients and reporting any of the outcomes evaluated were included. Pooled estimates of the tree outcomes were calculated with a fixed or random-effects model...
March 26, 2024: International Journal of Infectious Diseases: IJID
#14
JOURNAL ARTICLE
Yi-Jung Huang, Tian-Lu Cheng, Yen-Tseng Wang, Chien-Shu Chen, Yu-Ling Leu, Chih-Shiang Chang, Cheng-Han Ho, Shi-Wei Chao, Chia-Tse Li, Chih-Hung Chuang
Dengue fever, an infectious disease prevalent in subtropical and tropical regions, currently lacks effective small-molecule drugs as treatment. In this study, we used a fluorescence peptide cleavage assay to screen seven compounds to assess their inhibition of the dengue virus (DENV) NS2B-NS3 protease. DV-B-120 demonstrated superior inhibition of NS2B-NS3 protease activity and lower toxicity compared to ARDP0006. The selectivity index of DV-B-120 was higher than that of ARDP0006. In vivo assessments of the antiviral efficacy of DV-B-120 against DENV replication demonstrated delayed mortality of suckling mice treated with the compound, with 60-80% protection against life-threatening effects, compared to the outcomes of DENV-infected mice treated with saline...
March 28, 2024: Journal of Virology
#15
REVIEW
Sarah R Sabo, Aarthi Venkatramanan, Andrew F Shorr
Severe infection represents a leading reason for admission to the intensive care unit (ICU) while nosocomial infection can arise as a complication of care in the ICU. The mortality and morbidity of such infections are substantial. These processes also put economic strain on the healthcare system. Additionally, the continued spread of antimicrobial resistance has made it more challenging both to prevent and treat severe infection. Until recently, there were few well-done trials addressing infection among the critically ill...
March 2, 2024: Biomedicines
#16
REVIEW
Karina Džermeikaitė, Justina Krištolaitytė, Ramūnas Antanaitis
The dairy industry is facing criticism for its role in exacerbating global GHG emissions, as climate change becomes an increasingly pressing issue. These emissions mostly originate from methane (CH4 ), nitrous oxide (N2 O), and carbon dioxide (CO2 ). An optimal strategy involves the creation of an economical monitoring device to evaluate methane emissions from dairy animals. Livestock production systems encounter difficulties because of escalating food demand and environmental concerns. Enhancing animal productivity via nutrition, feeding management, reproduction, or genetics can result in a decrease in CH4 emissions per unit of meat or milk...
March 7, 2024: Animals: An Open Access Journal From MDPI
#17
JOURNAL ARTICLE
Marin Moutel, Edwidge Peju, Martin Belan, Ariane Gavaud, Jean-Paul Mira, Caroline Charlier, Etienne Canouï, Nabil Gastli
INTRODUCTION: Hypervirulent Klebsiella pneumoniae (hvKP) bloodstream infections (BSI) have rarely been reported in critically ill patients. METHODS: We conducted a retrospective study of KP-BSI between January 2016 and December 2020 in an adult medical intensive care unit (ICU) of our tertiary care hospital. Hypervirulent phenotype was defined by the detection of both rmpA and iutA. RESULTS: Seventy patients diagnosed with K. pneumonia BSI were included, of whom 9 (13 %) had hvKP infection...
March 21, 2024: Infectious diseases now
#18
JOURNAL ARTICLE
Pauline Yeung Ng, April Ip, Andrew Kei-Yan Ng, Simon Wai-Ching Sin, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Desmond Yat-Hin Yap
BACKGROUND: The SARS-CoV-2 virus can bind to angiotensin-converting enzyme 2 receptors on host renal cells and may cause acute kidney injury (AKI). The comparative risks of AKI in patients severely ill with COVID-19 and influenza A have not been examined. METHODS: This is a retrospective cohort study including patients with positive PCR results for SARS-CoV-2 or influenza A virus admitted to the intensive care units (ICUs) of 15 public hospitals in Hong Kong between 1st January 2013 and 30th April 2023...
April 2024: EClinicalMedicine
#19
JOURNAL ARTICLE
Matteo Bassetti, Daniele R Giacobbe, Christina Agvald-Ohman, Murat Akova, Ana Alastruey-Izquierdo, Sevtap Arikan-Akdagli, Elie Azoulay, Stijn Blot, Oliver A Cornely, Manuel Cuenca-Estrella, Dylan W de Lange, Francesco G De Rosa, Jan J De Waele, George Dimopoulos, Jose Garnacho-Montero, Martin Hoenigl, Souha S Kanj, Philipp Koehler, Bart J Kullberg, Frédéric Lamoth, Cornelia Lass-Flörl, Johan Maertens, Ignacio Martin-Loeches, Patricia Muñoz, Garyphallia Poulakou, Jordi Rello, Maurizio Sanguinetti, Fabio S Taccone, Jean-François Timsit, Antoni Torres, Jose A Vazquez, Joost Wauters, Erika Asperges, Andrea Cortegiani, Cecilia Grecchi, Ilias Karaiskos, Clément Le Bihan, Toine Mercier, Klaus L Mortensen, Maddalena Peghin, Chiara Rebuffi, Sofia Tejada, Antonio Vena, Valentina Zuccaro, Luigia Scudeller, Thierry Calandra
PURPOSE: The aim of this document was to develop standardized research definitions of invasive fungal diseases (IFD) in non-neutropenic, adult patients without classical host factors for IFD, admitted to intensive care units (ICUs). METHODS: After a systematic assessment of the diagnostic performance for IFD in the target population of already existing definitions and laboratory tests, consensus definitions were developed by a panel of experts using the RAND/UCLA appropriateness method...
March 21, 2024: Intensive Care Medicine
#20
JOURNAL ARTICLE
Jialong Chen, Jing Lin, Jianzhen Weng, Yang Ju, Yanming Li
BACKGROUND: Vancomycin-associated acute kidney injury (VA-AKI) is the most clinically relevant side effect of vancomycin. The objective of this study was to investigate the association between VTC and VA-AKI as well as 30-day mortality in critically ill elderly adults. METHOD: Elderly patients with trough serum vancomycin concentration records(VTC) in the Medical Information Mart-IV (MIMIC-IV) and eICU databases were retrospectively studied. RESULTS: A total of 3,146 critically ill elderly adults were finally enrolled...
March 20, 2024: BMC Infectious Diseases
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