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Sentinel node endometrial cancer

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https://www.readbyqxmd.com/read/29691646/retrospective-validation-of-the-laparoscopic-icg-sln-mapping-in-patients-with-grade-3-endometrial-cancer
#1
Andrea Papadia, Maria Luisa Gasparri, Anda P Radan, Chantal A L Stämpfli, Tilman T Rau, Michael D Mueller
PURPOSE: To evaluate the sensitivity, negative predictive value (NPV) and false-negative (FN) rate of the near infrared (NIR) indocyanine green (ICG) sentinel lymph node (SLN) mapping in patients with poorly differentiated endometrial cancer who have undergone a full pelvic and para-aortic lymphadenectomy after SLN mapping. METHODS: We performed a retrospective analysis of patients with endometrial cancer undergoing a laparoscopic NIR-ICG SLN mapping followed by a systematic pelvic and para-aortic lymphadenectomy...
April 24, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29660577/value-and-best-way-for-detection-of-sentinel-lymph-node-in-early-stage-endometrial-cancer-selective-lymphadenectomy-algorithm
#2
Ahmed Samy El-Agwany, Mahmoud Hanafy Meleis
INTRODUCTION: The cornerstone of treatment for endometrial carcinoma is total abdominal hysterectomy and bilateral salpingo-oophoprectomy. Pelvic lymphadenectomy, with or without para-aortic lymphadenectomy, plays an important role in the surgical staging of endometrial carcinoma, and provides more accurate prognostic information. AIMS: We aimed to evaluate the value and techniques for SLN mapping in early stage endometrial cancer with low risk for lymph node metastasis and whether selective or systematic lymphadenectomy is needed according to the results of proposed algorithm...
March 23, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29565689/trends-in-sentinel-lymph-node-mapping-and-adjuvant-therapy-in-endometrial-carcinoma
#3
Natalia R Gómez-Hidalgo, Ling Chen, June Y Hou, Ana I Tergas, Caryn M St Clair, Cande V Ananth, Dawn L Hershman, Jason D Wright
We analyzed 54,039 women with uterine cancer in the National Cancer Database from 2013 to 2014 including 38,453 (71.2%) who underwent lymphadenectomy, 1929 (3.6%) who underwent sentinel lymph node (SLN) mapping, and 13,657 (25.3%) who did not undergo nodal assessment. SLN mapping increased from 2.8% in 2013 to 4.3% in 2014 (P < 0.001). Patients treated in 2014 and those at community centers were more likely to undergo SLN biopsy, while women with advanced-stage disease, sarcomas, and grade 3 tumors were less likely to undergo SLN mapping (P < 0...
March 22, 2018: Cancer Investigation
https://www.readbyqxmd.com/read/29554604/a-prospective-evaluation-of-the-sentinel-node-mapping-algorithm-in-endometrial-cancer-and-correlation-of-its-performance-against-endometrial-cancer-risk-subtypes
#4
Anupama Rajanbabu, Reshu Agarwal
OBJECTIVE: Sentinel node mapping is emerging as the alternative to lymphadenectomy in endometrial cancer. The objective of our study is to validate of the sentinel node mapping surgical algorithm and also to compare the performance of the algorithm against endometrial cancer risk subtypes DESIGN: This is a prospective interventional study carried out at a Single University teaching hospital. All patients with apparent early stage endometrial cancer who underwent robotic assisted surgical staging were included...
March 13, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29538256/the-issue-of-aortic-sentinel-node-detection-in-endometrial-cancer
#5
Mikel Gorostidi, Ruben Ruiz, Ibon Jaunarena
No abstract text is available yet for this article.
March 12, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29529474/the-safety-and-feasibility-of-minimally-invasive-sentinel-lymph-node-staging-using-indocyanine-green-in-the-management-of-endometrial-cancer
#6
Alberto A Mendivil, Lisa N Abaid, John V Brown, Kristina M Mori, Tiffany L Beck, Howard D Epstein, John P Micha, Bram H Goldstein
OBJECTIVES: The purpose of this study was to report on the feasibility of laparoscopic sentinel lymph node (SLN) staging using indocyanine green (ICG) in the management of endometrial cancer. STUDY DESIGN: We retrospectively evaluated the charts of presumed, clinical stage I endometrial cancer patients who underwent robotic-assisted surgery that incorporated mapping with ICG and SLN dissection from January 2016 until February 2017. Patient demographics, operative characteristics (e...
March 3, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29501809/maximizing-sentinel-lymph-node-detection-aortic-sentinel-lymph-node-detection-on-endometrial-cancer
#7
Mikel Gorostidi, Cecilia Villalain, Ruben Ruiz, Ibon Jaunarena, Arantxa Lekuona, Irene Diez
STUDY OBJECTIVE: To determine the importance of a dual (cervical and fundal) indocyanine green (ICG) injection and a thorough dissection for the detection of sentinel lymph node (SLN). DESIGN: Step-by-step description of a surgical procedure using video (Canadian Task Force III) SETTING: Hospital Universitario Donostia (Spain). PATIENTS: A 60-year-old woman with a diagnosis of IAG1 endometrial adenocarcinoma (EC). INTERVENTIONS: The patient underwent a cervical and transcervical fundal ICG injection for paraortic and pelvic SLN detection in the setting of a research protocol and a total hysterectomy and bilateral salpingo-oophorectomy with frozen section of the uterus as standard approach (1)...
March 1, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29470188/extrapelvic-sentinel-lymph-nodes-in-endometrial-cancer-patients-with-unmapped-pelvic-side-a-brief-report
#8
Salih Taşkin, Duygu Altin, Yavuz Emre Şükür, Firat Ortaç
OBJECTIVE: The aim of the study was to evaluate extrapelvic sentinel lymph nodes (SLNs) in clinical early-stage endometrial cancer patients with unmapped pelvic side(s) during fluorescent imaging-based sentinel mapping. MATERIALS AND METHODS: Eligible patients underwent sentinel mapping using cervical injection of indocyanine green and near-infrared florescent imaging compatible endoscopic systems. Pelvic SLNs were identified and resected. If bilateral mapping was not achieved, upper lymph nodes areas including presacral, upper common iliac, and para-aortic caval regions were explored for any SLN...
February 22, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29468855/major-clinical-research-advances-in-gynecologic-cancer-in-2017
#9
REVIEW
Dong Hoon Suh, Miseon Kim, Kyung Hun Lee, Keun Yong Eom, Maj Kamille Kjeldsen, Mansoor Raza Mirza, Jae Weon Kim
In 2017, 10 topics were selected as major clinical research advances in gynecologic oncology. For cervical cancer, efficacy and safety analysis results of a 9-valent human papillomavirus (HPV) vaccine and long-term impact of reduced dose of quadrivalent vaccine were updated. Brief introduction of KEYNOTE trials of pembrolizumab, a monoclonal antibody that blocks the interaction between programmed death (PD)-1 and its ligands, PD-L1 and PD-L2, followed. Tailored surveillance programs for gynecologic cancer related with Lynch syndrome and update on sentinel lymph node mapping were reviewed for uterine corpus cancer...
March 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29427781/retroperitoneal-laparoscopic-para-aortic-lymphadenectomy-in-para-aortic-staging-of-locally-advanced-cervical-cancer
#10
Daniel Vázquez-Vicente, Bárbara Fernández Del Bas, José García Villayzán, Javier Plaza Arranz, Luis Chiva
STUDY OBJECTIVE: To review/learn a surgical technique not very well-known by gynecologic oncologists. DESIGN: Level of evidence III. SETTING: A review of a surgical technique with emphasis on the para-aortic sentinel lymph nodes using indocyanine green. INTERVENTION: The film features the following steps to perform the procedure: 1. Creating a retroperitoneal window. 2. What to do if the peritoneum is torn. 3. Finding the psoas muscle, right ureter, and common iliac artery...
February 7, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29290489/the-utility-of-sentinel-lymph-node-mapping-in-the-management-of-endometrial-atypical-hyperplasia
#11
Omar Touhami, Jean Grégoire, Marie-Claude Renaud, Alexandra Sebastianelli, Katherine Grondin, Marie Plante
OBJECTIVES: To determine the risk of endometrial cancer (EC) and lymph node involvement in patients with a preoperative diagnosis of "AH-only" versus "AH - cannot rule out carcinoma" and to study the value of SLN mapping. METHODS: We reviewed all patients with a preoperative diagnosis of atypical hyperplasia, who underwent primary surgery with SLN mapping followed by pelvic lymphadenectomy. Sensitivity and negative predictive value (NPV) of SLN and rates of endometrial cancer were calculated...
March 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29273307/sentinel-lymph-node-biopsy-in-endometrial-cancer-feasibility-safety-and-lymphatic-complications
#12
Barbara Geppert, Céline Lönnerfors, Michele Bollino, Jan Persson
OBJECTIVE: To compare the rate of lymphatic complications in women with endometrial cancer undergoing sentinel lymph node biopsy versus a full pelvic and infrarenal paraaortic lymphadenectomy, and to examine the overall feasibility and safety of the former. METHODS: A prospective study of 188 patients with endometrial cancer planned for robotic surgery. Indocyanine green was used to identify the sentinel lymph nodes. In low-risk patients the lymphadenectomy was restricted to removal of sentinel lymph nodes whereas in high-risk patients also a full lymphadenectomy was performed...
March 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29213225/role-of-blue-dye-for-sentinel-lymph-node-detection-in-early-endometrial-cancer
#13
Stefano Restaino, Carlo Ronsini, Angelo Finelli, Emanuele Perrone, Giovanni Scambia, Francesco Fanfani
Background: Sentinel Lymphonode analysis has become a barely new and innovative way to treat early stages of endometrial cancer (Ballester et al., Lancet Oncol 469-476, 2011; Buda et al., Ann Surg Oncol 2975-81, 2016). Indocyanine green cervical injection is considered gold standard for mapping nodes' drainage. Blue dye is used as a valid alternative in many centers, due to the lower cost of execution. The objective of this video is to prove that methylene blue dye's cervical injection is a valid and "low-cost" method to obtain mapping of lymphatic drainage in patient with early endometrial cancer...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/29194192/sentinel-node-biopsy-in-endometrial-cancer-with-dual-cervical-and-fundal-indocyanine-green-injection
#14
Ruben Ruiz, Mikel Gorostidi, Ibon Jaunarena, Constance Goiri, Justina Aguerre, Arantxa Lekuona
PURPOSE: The aim of this study was describe a novel sentinel lymph node (SLN) tracer injection procedure featuring dual cervical and fundal indocyanine green (ICG) injection for endometrial cancer and results of SLN biopsy. METHODS: Between June 26, 2014 and October 31, 2016, 111 patients underwent laparoscopic surgery for endometrial cancer at our institution. In all cases, we performed SLN biopsy with dual cervical and fundal ICG injection. All SLNs were processed with an ultrastaging technique...
January 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29185673/sentinel-lymph-node-mapping-in-endometrial-cancer-a-systematic-review-and-meta-analysis
#15
Jeffrey A How, Patrick O'Farrell, Zainab Amajoud, Susie Lau, Shannon Salvador, Emily How, Walter H Gotlieb
INTRODUCTION: Appropriate extent of lymphadenectomy in clinically, early stage endometrial cancer remains controversial but sentinel lymph node (SLN) mapping has emerged as an alternative staging strategy, until the advent of molecular prognostic markers. We sought to perform a systematic review of the literature to determine pooled estimates for SLN detection rate and diagnostic accuracy, while exploring impact of the SLN on adjuvant therapy and oncologic outcomes. EVIDENCE ACQUISITION: We performed a systematic search utilizing Medline, EMBASE, and Web of Science electronic databases for all studies published in the English language until October 31, 2017...
April 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29184876/feasibility-of-sentinel-lymph-node-dissection-using-tc-99m-phytate-in-papillary-thyroid-carcinoma
#16
Se Hyun Paek, Ka Hee Yi, Su-Jin Kim, June Young Choi, Kyu Eun Lee, Young Joo Park, Do-Joon Park, Keon Wook Kang, June-Key Chung
Purpose: Various methods of sentinel lymph node (SLN) biopsy in thyroid cancer have been introduced. Tc-99m phytate as a radiotracer has been successfully utilized for SLN biopsy in breast, cervix, and endometrial cancer. We assessed the feasibility of SLN dissection using Tc-99m phytate in papillary thyroid carcinoma (PTC). Methods: Seventeen patients with PTC were prospectively enrolled. Ultrasound-guided peritumoral injection of 55.5 MBq Tc-99m phytate in 0.25-mL normal saline was performed...
November 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29173977/-european-guidelines-esmo-esgo-estro-consensus-conference-for-the-management-of-endometrial-cancer
#17
Marcos Ballester, Sofiane Bendifallah, Emile Daraï
Endometrial cancer (EC) is a major source of morbidity and mortality in women worldwide. In France, in 2015, EC was the first gynecological cancer in terms of incidence. Its prognosis is considered favorable because it is most often limited to the uterus at diagnosis. Nevertheless, it is a heterogeneous pathology and 5-year overall survival can vary from 92 % to 42 % in FIGO stage I depending on its histological characteristics. This great heterogeneity leads to important disparities in its surgical management as well as in indications for adjuvant therapies...
December 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29146390/laparoendoscopic-single-site-sentinel-lymph-node-detection-in-endometrial-cancer
#18
Gökhan Demirayak, Cihan Comba, İsa Aykut Özdemir
STUDY OBJECTIVE: To demonstrate the feasibility of sentinel lymph node (SLN) biopsy using a laparoendoscopic single-site (LESS) approach in endometrial cancer (EC). DESIGN: A step-by-step video demonstration of the surgical procedure (Canadian Task Force Classification III). SETTING: The satisfaction of patients who undergo LESS hysterectomy is greater than that reported by patients who undergo multiport laparoscopic hysterectomy, owing to better cosmesis and reduced postoperative analgesic requirements [1]...
November 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29121779/image-guided-surgery-in-gynecologic-oncology
#19
Henri Azaïs, Geoffroy Canlorbe, Yohan Kerbage, Anne Grabarz, Pierre Collinet, Serge Mordon
Image-guided surgery is a relevant way to reduce surgical morbidity and maximize cytoreductive surgery approach especially in ovarian cancer. Sentinel lymph node detection is a promising approach to avoid radical lymph node dissection and is slightly becoming standard in daily practice in endometrial and cervical cancer surgery even if it needs to be evaluated more precisely. Regarding carcinomatosis of ovarian origin, detection and treatment of microscopic disease could be appropriate to avoid local recurrences...
November 10, 2017: Future Oncology
https://www.readbyqxmd.com/read/29098518/the-detection-of-sentinel-lymph-nodes-in-laparoscopic-surgery-can-eliminate-systemic-lymphadenectomy-for-patients-with-early-stage-endometrial-cancer
#20
Tomohito Tanaka, Yoshito Terai, Satoe Fujiwara, Yoshimichi Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Kazuhiro Yamamoto, Takashi Yamada, Masahide Ohmichi
BACKGROUND: The examination of a sentinel lymph node (SLN), where lymph node metastasis first occurs, may be advocated as an alternative staging technique. The aim of this study was to evaluate the feasibility and detection rates of an SLN biopsy in patients with endometrial cancer. STUDY DESIGN: Two hundred and eleven patients with endometrial cancer underwent an SLN biopsy at hysterectomy using three kinds of tracers including 99m-technetium-labeled tin colloid (99m Tc), indigo carmine and indocyanine green...
November 2, 2017: International Journal of Clinical Oncology
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