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Sentinel node endometrial cancer

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https://www.readbyqxmd.com/read/28807805/laparoscopic-sentinel-node-mapping-in-cervical-and-endometrial-malignancies-a-case-control-study-comparing-two-near-infrared-fluorescence-systems
#1
Alessandro Buda, Giampaolo Di Martino, Elena De Ponti, Paolo Passoni, Federica Sina, Claudio Reato, Francesca Vecchione, Daniela Giuliani
STUDY OBJECTIVE: the goal of this study was to evaluate the intraoperative and perioperative surgical outcomes of two different florescence systems commonly utilized for sentinel lymph node (SLN) mapping in women with early stage cervical cancer or endometrial cancer. DESIGN: Case-control study. DESIGN CLASSIFICATION: Canadian Task-force II-2 SETTING: The study was conducted in the Gynecology Oncology Surgical Unit of the San Gerardo Hospital, Italy...
August 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28751118/description-of-a-reproducible-anatomically-based-surgical-algorithm-for-detection-of-pelvic-sentinel-lymph-nodes-in-endometrial-cancer
#2
Jan Persson, Barbara Geppert, Céline Lönnerfors, Michele Bollino, Anna Måsbäck
OBJECTIVE: To describe and evaluate a reproducible, anatomically based surgical algorithm, including reinjection of tracer to enhance technical success rate, for detection of pelvic sentinel lymph nodes (SLNs) in endometrial cancer (EC). METHODS: A prospective study of 102 consecutive women with high risk EC scheduled for robotic surgery was conducted. Following cervical injection of a fluorescent dye, an algorithm for trans- and retroperitoneal identification of tracer display in the lower and upper paracervical pathways was strictly adhered to...
July 24, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28741261/hereditary-breast-cancer-associated-with-cowden-syndrome-related-pten-mutation-with-lhermitte-duclos-disease
#3
Fuyo Kimura, Ai Ueda, Eiichi Sato, Jiro Akimoto, Hiroshi Kaise, Kimito Yamada, Mari Hosonaga, Yuko Kawai, Saeko Teraoka, Miki Okazaki, Takashi Ishikawa
BACKGROUND: Cowden syndrome is characterized by multiple hamartomas in various tissues, including the skin, brain, breast, thyroid, mucous membrane, and gastrointestinal tract, and is reported to increase the risk of malignant disease. CASE PRESENTATION: We describe the case of a 52-year-old woman in whom a tumor was diagnosed in the left cerebellar hemisphere and treated by surgical resection. Phosphatase and tensin homolog (PTEN) mutation in exon 8 insertion was found in the brain tumor tissue and leukocytes...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28716308/unexpected-locations-of-sentinel-lymph-nodes-in-endometrial-cancer
#4
Jeffrey How, Irina Boldeanu, Susie Lau, Shannon Salvador, Emily How, Raphael Gotlieb, Jeremie Abitbol, Ajay Halder, Zainab Amajoud, Stephan Probst, Sonya Brin, Walter Gotlieb
INTRODUCTION: To evaluate the anatomical location of sentinel lymph nodes (SLN) following intra-operative cervical injection in endometrial cancer. METHODS: All consecutive patients with endometrial cancer undergoing sentinel lymph node mapping were included in this prospective study following intra-operative cervical injection of tracers. Areas of SLN detection distribution were mapped. RESULTS: Among 436 patients undergoing SLN mapping, there were 1095 SLNs removed, and 7...
July 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28629611/sentinel-lymph-node-mapping-in-minimally-invasive-surgery-role-of-imaging-with-color-segmented-fluorescence-csf
#5
Maite I Lopez Labrousse, Michael Frumovitz, M Guadalupe Patrono, Pedro T Ramirez
OBJECTIVE: Sentinel lymph node mapping, alone or in combination with pelvic lymphadenectomy, is considered a standard approach in staging of patients with cervical or endometrial cancer [1-3]. The goal of this video is to demonstrate the use of indocyanine green (ICG) and color-segmented fluorescence when performing lymphatic mapping in patients with gynecologic malignancies. METHODS: Injection of ICG is performed in two cervical sites using 1mL (0.5mL superficial and deep, respectively) at the 3 and 9 o'clock position...
June 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28625394/sentinel-node-mapping-in-endometrial-cancer-following-hysteroscopic-injection-of-tracers-a-single-center-evaluation-over-200-cases
#6
Fabio Martinelli, Antonino Ditto, Mauro Signorelli, Giorgio Bogani, Valentina Chiappa, Domenica Lorusso, Cono Scaffa, Dario Recalcati, Stefania Perotto, Edward Haeusler, Francesco Raspagliesi
OBJECTIVES: To analyze detection-rate(DR) and diagnostic-accuracy (A) of sentinel-nodes(SLNs) mapping following hysteroscopic-injection of tracer. To compare DR and A between tracers: ICG and Tc99m. METHODS: Evaluation of endometrial-cancer patients who underwent SLNs mapping after hysteroscopic-peritumoral-injection of tracer±lymphadenectomy. Analysis of DR (overall-bilateral-aortic) and A in the entire cohort and comparison between tracers. RESULTS: 202 procedures were performed from January/2005 to February/2017...
June 15, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28604450/low-volume-lymph-node-metastases-in-endometrial-carcinoma
#7
Lani K Clinton, Jordan Kondo, Michael E Carney, Pamela Tauchi-Nishi, Keith Terada, David Shimizu
OBJECTIVE: The aim of this study was to determine the histopathologic characteristics of patients with endometrial carcinoma with low-volume metastases (micrometastases and isolated tumor cells) compared with macrometastases. METHODS: We performed a retrospective review of patients with endometrial carcinoma. RESULTS: Among 350 robotic-assisted hysterectomies for endometrial cancer, 187 (53%) underwent attempted sentinel lymph node (SLN) biopsy...
July 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28599884/comparing-single-site-and-multiport-robotic-hysterectomy-with-sentinel-lymph-node-mapping-for-endometrial-cancer-surgical-outcomes-and-cost-analysis
#8
Lea A Moukarzel, Abdulrahman K Sinno, Amanda N Fader, Edward J Tanner
STUDY OBJECTIVE: To compare operative times, surgical outcomes, and costs of robotic laparoendoscopic single-site (R-LESS) vs multiport robotic (MPR) total laparoscopic hysterectomy (TLH) with sentinel lymph node (SLN) mapping for low-risk endometrial cancer. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: Academic university hospital. PATIENTS: Patients with a biopsy-proven diagnosis of complex atypical hyperplasia (CAH) or low-grade (1 or 2) endometrial cancer with body mass index <30 kg/m(2) and undergoing robotic TLH and SLN mapping between 2012 and 2016 were included...
June 7, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28577885/isolated-tumor-cells-identified-by-sentinel-lymph-node-mapping-in-endometrial-cancer-does-adjuvant-treatment-matter
#9
Marie Plante, Jonathan Stanleigh, Marie-Claude Renaud, Alexandra Sebastianelli, Katherine Grondin, Jean Grégoire
OBJECTIVE: To evaluate the outcome and the role of adjuvant treatment in the management of patients with endometrial cancer and isolated tumor cells (ITCs) identified by SLN mapping. METHODS: This single center study identified all patients undergoing hysterectomy, salpingo-oophorectomy, lymphadenectomy and SLN mapping for endometrial cancer between November 2010 and December 2015. Data was prospectively collected. Progression-free survival was analyzed according to the Kaplan-Meier method and compared using the log-rank test...
August 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28566221/sentinel-lymph-node-mapping-and-staging-in-endometrial-cancer-a-society-of-gynecologic-oncology-literature-review-with-consensus-recommendations
#10
REVIEW
Robert W Holloway, Nadeem R Abu-Rustum, Floor J Backes, John F Boggess, Walter H Gotlieb, W Jeffrey Lowery, Emma C Rossi, Edward J Tanner, Rebecca J Wolsky
The emphasis in contemporary medical oncology has been "precision" or "personalized" medicine, terms that imply a strategy to improve efficacy through targeted therapies. Similar attempts at precision are occurring in surgical oncology. Sentinel lymph node (SLN) mapping has recently been introduced into the surgical staging of endometrial cancer with the goal to reduce morbidity associated with comprehensive lymphadenectomy, yet obtain prognostic information from lymph node status. The Society of Gynecologic Oncology's (SGO) Clinical Practice Committee and SLN Working Group reviewed the current literature for preparation of this document...
August 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28562470/a-comparison-of-dye-versus-fluorescence-methods-for-sentinel-lymph-node-mapping-in-endometrial-cancer
#11
Wataru Yamagami, Nobuyuki Susumu, Fumio Kataoka, Takeshi Makabe, Kensuke Sakai, Tomomi Ninomiya, Michiko Wada, Hiroyuki Nomura, Akira Hirasawa, Kouji Banno, Tadaki Nakahara, Kaori Kameyama, Daisuke Aoki
OBJECTIVE: Sentinel nodes (SNs) have been observed in several reports from Japan and overseas in cases with endometrial cancer; however, no consensus has been reached regarding the types of tracers or the method of their injection. A combination of the radioisotope (RI) and dye method is considered to be desirable. We assessed SN mapping using either dye or near-infrared fluorescence imaging to clarify a suitable method in cases of endometrial cancer. METHODS: Patients were enrolled from 92 patients diagnosed with endometrial cancer and having no extrauterine metastasis by the preoperative imaging between 2009 and 2014 at our institution...
May 29, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28558116/sentinel-lymph-node-technique-in-endometrial-cancer
#12
Allison Staley, Stephanie A Sullivan, Emma C Rossi
Importance: Endometrial cancer (EMCA) is the most common gynecologic malignancy, with an estimated 54,000 new cases and 10,000 deaths in the United States in 2015. Lymph node metastasis is the most significant prognostic factor in EMCA. Sentinel lymph node (SLN) mapping has become a well-accepted procedure in surgical oncology and may strike a balance between the risks and benefits of lymphadenectomy. Objective: The aim of this study was to review the current literature regarding the history, techniques, and clinical application of SLN mapping in EMCA...
May 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28533155/indications-and-techniques-for-robotic-pelvic-and-para-aortic-lymphadenectomy-with-sentinel-lymph-node-mapping-in-gynecologic-oncology
#13
REVIEW
Ketura Preya A Wisner, Sarfraz Ahmad, Robert W Holloway
Robotic-assisted laparoscopic surgery is the most common approach for the treatment of early-stage endometrial and cervical cancers in the US. Surgical staging requires pelvic and often aortic lymphadenectomy, depending on the primary tumor characteristics. Pelvic and aortic lymphadenectomy procedures may also be indicated for debulking of larger metastases to improve disease control. The infra-renal basin is an important anatomic site of metastasis from pelvic tumors, and robotic dissection techniques for this site have been described...
April 24, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28528918/a-prospective-validation-study-of-sentinel-lymph-node-mapping-for-high-risk-endometrial-cancer
#14
Pamela T Soliman, Shannon N Westin, Shayan Dioun, Charlotte C Sun, Elizabeth Euscher, Mark F Munsell, Nicole D Fleming, Charles Levenback, Michael Frumovitz, Pedro T Ramirez, Karen H Lu
OBJECTIVE: Sentinel lymph node (SLN) mapping continues to evolve in the surgical staging of endometrial cancer (EC). The purpose of this trial was to identify the sensitivity, false negative rate (FNR) and FN predictive value (FNPV) of SLN compared to complete pelvic and para-aortic lymphadenectomy (LAD) in women with high-risk EC. METHODS: Women with high-risk EC (grade 3, serous, clear cell, carcinosarcoma) were enrolled in this prospective surgical trial. All patients underwent preoperative PET/CT and intraoperative SLN biopsy followed by LAD...
August 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28515257/minimally-invasive-techniques-for-treating-gynecologic-malignancies
#15
Amanda N Fader
For many women with endometrial and cervical cancers, minimally invasive surgery represents an alternative standard of care to open abdominal procedures, with fewer complications, better postoperative quality of life, and overall lower cost. At the NCCN 22nd Annual Conference, Amanda N. Fader, MD, reviewed several minimally invasive strategies for treating gynecologic cancers, including conventional laparoscopy, robotic-assisted laparoscopy, sentinel lymph node technology, and single-port surgery; highlighted some of the contemporary literature on the role of these procedures; and explored some of the challenges and barriers to their successful performance...
May 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28484664/sentinel-lymph-node-mapping-in-patients-with-endometrial-carcinoma-less-can-be-more
#16
Mario M Leitao
PURPOSE OF REVIEW: The role and extent of lymphadenectomy for endometrial carcinoma has been debated for over 30 years. Many clinicians argue that there is therapeutic value for lymphadenectomy in patients deemed to be "at risk", a designation not universally defined, despite the lack of randomized data supporting this argument. However, lymphadenectomy is associated with morbidity, including lower extremity lymphedema. Sentinel lymph node (SLN) mapping is emerging as a viable alternative to comprehensive lymphadenectomy in the surgical staging of patients with endometrial cancer...
December 2016: Current Obstetrics and Gynecology Reports
https://www.readbyqxmd.com/read/28410225/sentinel-lymph-node-mapping-in-endometrial-cancer-a-systematic-review-and-meta-analysis
#17
REVIEW
Hefeng Lin, Zheyuan Ding, Vishnu Goutham Kota, Xiaoming Zhang, Jianwei Zhou
Endometrial cancer is the most frequent tumor in the female reproductive system, while the sentinel lymph node (SLN) mapping for diagnostic efficacy of endometrial cancer is still controversial. This meta-analysis was conducted to evaluate the diagnostic value of SLN in the assessment of lymph nodal involvement in endometrial cancer. Forty-four studies including 2,236 cases were identified. The pooled overall detection rate was 83% (95% CI: 80-86%). The pooled sensitivity was 91% (95% CI: 87-95%). The bilateral pelvic node detection rate was 56% (95% CI: 48-64%)...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28374119/sentinel-lymph-node-mapping-using-spect-ct-and-gamma-probe-in-endometrial-cancer-an-analysis-of-parameters-affecting-detection-rate
#18
Samine Sahbai, Florin-Andrei Taran, Annette Staebler, Diethelm Wallwiener, Christian la Fougère, Sara Brucker, Helmut Dittmann
PURPOSE: SPECT/CT after pericervical injection of technetium-99 m-nanocolloid was shown to be suitable for sentinel lymph node (SLN) mapping in endometrial cancer (EC). The aim of this study was to analyze factors affecting successful SLN detection by means of SPECT/CT such as imaging findings, patient characteristics and tumor biology in a large cohort of patients. METHODS: One hundred and forty-five consecutive patients suffering from EC who received pre-surgical SLN mapping at our institution between 2011 and 2016 were included in this analysis...
August 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28363672/sentinel-lymph-node-mapping-reduces-practice-pattern-variations-in-surgical-staging-for-endometrial-adenocarcinoma-a-before-and-after-study
#19
Christina Y Liu, Kevin M Elias, Brooke E Howitt, Larissa J Lee, Colleen M Feltmate
OBJECTIVE: To examine the effects of universal sentinel lymph node mapping on the use of nodal staging in endometrial adenocarcinoma. METHODS: Two approaches to laparoscopic staging for endometrial adenocarcinoma were compared using a before and after study design. The before cohort underwent selective lymphadenectomy from January 1, 2014-October 1, 2015 while the after cohort underwent universal sentinel lymph node (SLN) mapping from October 2, 2015-September 29, 2016...
May 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28345826/value-of-sentinel-lymph-node-sln-mapping-and-biopsy-using-combined-intracervical-radiotracers-and-blue-dye-injections-for-endometrial-cancer
#20
Farah Farzaneh, Atefeh Moridi, Zahra Azizmohammadi, Mojtaba Ansari J, Maryam Sadat Hosseini, Maliheh Arab, Tahereh Ashrafganjoei, Mina Mazaheri
Background: Lymphadenectomy, as part of the initial surgical staging of patients with endometrial carcinoma, remains a controversial topic in gynecologic oncology. Sentinel lymph node (SLN) mapping has become a well-accepted procedure for melanomas and breast cancer; a number of investigators have begun to explore the utility and accuracy of this technique with regard to endometrial cancer. Aim: This study was conducted to evaluate SLN mapping of early stage endometrial cancer with blue dye in conjunction with a radioactive tracer...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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