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Sentinel node endometrial cancer

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https://www.readbyqxmd.com/read/29427781/retroperitoneal-laparoscopic-paraaortic-lymphadenectomy-in-paraaortical-staging-of-locally-advanced-cervical-cancer
#1
Daniel Vázquez-Vicente, Bárbara Fernández Del Bas, José García Villayzán, Javier Plaza Arranz, Luis Chiva
STUDY OBJECTIVE: The objective was to review/learn a surgical technique not very well known by gynecologic oncologists. DESIGN: Level of evidence: III SETTING: Review of a surgical technique with emphasis on the paraaortic sentinel lymph nodes using indocyanine green. INTERVENTION: The film features the following steps to perform the procedure: 1. Creating a retroperitoneal window. 2. What to do if the peritoneum is torn. 3. Finding the psoas muscle, right ureter, and common iliac artery...
February 7, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29290489/the-utility-of-sentinel-lymph-node-mapping-in-the-management-of-endometrial-atypical-hyperplasia
#2
Omar Touhami, Jean Grégoire, Marie-Claude Renaud, Alexandra Sebastianelli, Katherine Grondin, Marie Plante
OBJECTIVES: To determine the risk of endometrial cancer (EC) and lymph node involvement in patients with a preoperative diagnosis of "AH-only" versus "AH - cannot rule out carcinoma" and to study the value of SLN mapping. METHODS: We reviewed all patients with a preoperative diagnosis of atypical hyperplasia, who underwent primary surgery with SLN mapping followed by pelvic lymphadenectomy. Sensitivity and negative predictive value (NPV) of SLN and rates of endometrial cancer were calculated...
December 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29273307/sentinel-lymph-node-biopsy-in-endometrial-cancer-feasibility-safety-and-lymphatic-complications
#3
Barbara Geppert, Céline Lönnerfors, Michele Bollino, Jan Persson
OBJECTIVE: To compare the rate of lymphatic complications in women with endometrial cancer undergoing sentinel lymph node biopsy versus a full pelvic and infrarenal paraaortic lymphadenectomy, and to examine the overall feasibility and safety of the former. METHODS: A prospective study of 188 patients with endometrial cancer planned for robotic surgery. Indocyanine green was used to identify the sentinel lymph nodes. In low-risk patients the lymphadenectomy was restricted to removal of sentinel lymph nodes whereas in high-risk patients also a full lymphadenectomy was performed...
December 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29213225/role-of-blue-dye-for-sentinel-lymph-node-detection-in-early-endometrial-cancer
#4
Stefano Restaino, Carlo Ronsini, Angelo Finelli, Emanuele Perrone, Giovanni Scambia, Francesco Fanfani
Background: Sentinel Lymphonode analysis has become a barely new and innovative way to treat early stages of endometrial cancer (Ballester et al., Lancet Oncol 469-476, 2011; Buda et al., Ann Surg Oncol 2975-81, 2016). Indocyanine green cervical injection is considered gold standard for mapping nodes' drainage. Blue dye is used as a valid alternative in many centers, due to the lower cost of execution. The objective of this video is to prove that methylene blue dye's cervical injection is a valid and "low-cost" method to obtain mapping of lymphatic drainage in patient with early endometrial cancer...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/29194192/sentinel-node-biopsy-in-endometrial-cancer-with-dual-cervical-and-fundal-indocyanine-green-injection
#5
Ruben Ruiz, Mikel Gorostidi, Ibon Jaunarena, Constance Goiri, Justina Aguerre, Arantxa Lekuona
PURPOSE: The aim of this study was describe a novel sentinel lymph node (SLN) tracer injection procedure featuring dual cervical and fundal indocyanine green (ICG) injection for endometrial cancer and results of SLN biopsy. METHODS: Between June 26, 2014 and October 31, 2016, 111 patients underwent laparoscopic surgery for endometrial cancer at our institution. In all cases, we performed SLN biopsy with dual cervical and fundal ICG injection. All SLNs were processed with an ultrastaging technique...
November 30, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29185673/sentinel-lymph-node-mapping-in-endometrial-cancer-a-systematic-review-and-meta-analysis
#6
Jeffrey A How, Patrick O'Farrell, Zainab Amajoud, Susie Lau, Shannon Salvador, Emily How, Walter H Gotlieb
INTRODUCTION: Appropriate extent of lymphadenectomy in clinically, early stage endometrial cancer remains controversial but sentinel lymph node (SLN) mapping has emerged as an alternative staging strategy, until the advent of molecular prognostic markers. We sought to perform a systematic review of the literature to determine pooled estimates for SLN detection rate and diagnostic accuracy, while exploring impact of the SLN on adjuvant therapy and oncologic outcomes. EVIDENCE ACQUISITION: We performed a systematic search utilizing Medline, Embase, and Web of Science electronic databases for all studies published in the English language until October 31, 2017...
November 28, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/29184876/feasibility-of-sentinel-lymph-node-dissection-using-tc-99m-phytate-in-papillary-thyroid-carcinoma
#7
Se Hyun Paek, Ka Hee Yi, Su-Jin Kim, June Young Choi, Kyu Eun Lee, Young Joo Park, Do-Joon Park, Keon Wook Kang, June-Key Chung
Purpose: Various methods of sentinel lymph node (SLN) biopsy in thyroid cancer have been introduced. Tc-99m phytate as a radiotracer has been successfully utilized for SLN biopsy in breast, cervix, and endometrial cancer. We assessed the feasibility of SLN dissection using Tc-99m phytate in papillary thyroid carcinoma (PTC). Methods: Seventeen patients with PTC were prospectively enrolled. Ultrasound-guided peritumoral injection of 55.5 MBq Tc-99m phytate in 0.25-mL normal saline was performed...
November 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29173977/-european-guidelines-esmo-esgo-estro-consensus-conference-for-the-management-of-endometrial-cancer
#8
Marcos Ballester, Sofiane Bendifallah, Emile Daraï
Endometrial cancer (EC) is a major source of morbidity and mortality in women worldwide. In France, in 2015, EC was the first gynecological cancer in terms of incidence. Its prognosis is considered favorable because it is most often limited to the uterus at diagnosis. Nevertheless, it is a heterogeneous pathology and 5-year overall survival can vary from 92 % to 42 % in FIGO stage I depending on its histological characteristics. This great heterogeneity leads to important disparities in its surgical management as well as in indications for adjuvant therapies...
December 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29146390/laparoendoscopic-single-site-less-sentinel-lymph-node-sln-detection-in-endometrial-cancer-ec
#9
Gökhan Demirayak, Cihan Comba, İsa Aykut Özdemir
No abstract text is available yet for this article.
November 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29121779/image-guided-surgery-in-gynecologic-oncology
#10
Henri Azaïs, Geoffroy Canlorbe, Yohan Kerbage, Anne Grabarz, Pierre Collinet, Serge Mordon
Image-guided surgery is a relevant way to reduce surgical morbidity and maximize cytoreductive surgery approach especially in ovarian cancer. Sentinel lymph node detection is a promising approach to avoid radical lymph node dissection and is slightly becoming standard in daily practice in endometrial and cervical cancer surgery even if it needs to be evaluated more precisely. Regarding carcinomatosis of ovarian origin, detection and treatment of microscopic disease could be appropriate to avoid local recurrences...
November 10, 2017: Future Oncology
https://www.readbyqxmd.com/read/29098518/the-detection-of-sentinel-lymph-nodes-in-laparoscopic-surgery-can-eliminate-systemic-lymphadenectomy-for-patients-with-early-stage-endometrial-cancer
#11
Tomohito Tanaka, Yoshito Terai, Satoe Fujiwara, Yoshimichi Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Kazuhiro Yamamoto, Takashi Yamada, Masahide Ohmichi
BACKGROUND: The examination of a sentinel lymph node (SLN), where lymph node metastasis first occurs, may be advocated as an alternative staging technique. The aim of this study was to evaluate the feasibility and detection rates of an SLN biopsy in patients with endometrial cancer. STUDY DESIGN: Two hundred and eleven patients with endometrial cancer underwent an SLN biopsy at hysterectomy using three kinds of tracers including 99m-technetium-labeled tin colloid ((99m)Tc), indigo carmine and indocyanine green...
November 2, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29058141/the-impact-of-sentinel-node-mapping-in-staging-high-risk-endometrial-cancer
#12
Glauco Baiocchi, Henrique Mantoan, Lillian Yuri Kumagai, Bruna Tirapelli Gonçalves, Levon Badiglian-Filho, Ademir Narciso de Oliveira Menezes, Carlos Chaves Faloppa, Louise De Brot, Alexandre Andre Balieiro Anastacio da Costa
BACKGROUND: This study aimed to determine the impact of sentinel lymph node (SLN)-mapping on the staging of high-risk endometrial cancer (endometrioid grade 3, serous, clear cell, carcinosarcoma, deep myometrial invasion, or angiolymphatic invasion). METHODS: The study analyzed a series of 236 patients treated at AC Camargo Cancer Center from June 2007 to February 2017. The compared 75 patients who underwent SLN-mapping (SLN group) with 161 patients who received pelvic ± para-aortic lymphadenectomy (N-SLN group)...
December 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29056441/use-of-a-novel-sentinel-lymph-node-mapping-algorithm-reduces-the-need-for-pelvic-lymphadenectomy-in-low-grade-endometrial-cancer
#13
Edward Tanner, Allison Puechl, Kimberly Levinson, Laura J Havrilesky, Abdulrahman Sinno, Angeles Alvarez Secord, Amanda N Fader, Paula S Lee
OBJECTIVES: To evaluate the capability of a novel sentinel lymph node (SLN) mapping algorithm to reduce the need for pelvic lymphadenectomy (PLND) in patients with low-grade (G1-2) endometrial cancer (LGEC). METHODS: Patients with LGEC underwent evaluation according to a novel lymphatic assessment algorithm during hysterectomy with SLN biopsy at two academic gynecologic oncology programs. Side-specific PLND was only performed if ipsilateral SLN mapping failed and high-risk uterine features were identified on frozen section (FS)...
December 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29038041/minilaparoscopy-vs-standard-laparoscopy-for-sentinel-node-dissection-a-pilot-study
#14
Stefano Uccella, Alessandro Buda, Chiara Morosi, Giampaolo Di Martino, Martina Delle Marchette, Claudio Reato, Jvan Casarin, Fabio Ghezzi
OBJECTIVE: To compare 3-mm minilaparoscopy and standard 5-mm laparoscopy for sentinel node (SLN) detection in apparent early stage endometrial cancer (EC). DESIGN: Retrospective study (Canadian Task Force II-2). SETTING: Two academic research centers. PATIENTS: Consecutive women with apparent early stage EC, who underwent surgical staging with SLN between November 2015 and April 2016. INTERVENTIONS: Total laparoscopic extrafascial hysterectomy + bilateral salpingo-oophorectomy and SLN attempt...
October 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29032824/the-impact-on-survival-of-two-different-staging-strategies-in-apparent-early-stage-endometrial-cancer-comparing-sentinel-lymph-nodes-mapping-algorithm-and-selective-lymphadenectomy-an-italian-retrospective-analysis-of-two-reference-centers
#15
MULTICENTER STUDY
Alessandro Buda, Giampaolo Di Martino, Stefano Restaino, Elena De Ponti, Giorgia Monterossi, Daniela Giuliani, Alfredo Ercoli, Federica Dell'Orto, Giorgia Dinoi, Tommaso Grassi, Giovanni Scambia, Francesco Fanfani
OBJECTIVE: The role of lymphadenectomy in endometrial cancer is still uncertain. We aimed to evaluate the survival outcomes of two different strategies in apparent uterine confined disease by comparing sentinel lymph node (SLN) mapping and selective lymphadenectomy (LD). METHODS: We retrospectively reviewed women with preoperative stage I endometrial cancer underwent surgical staging with either SLN mapping, or LD in two Italian centers. RESULTS: Eight hundred and two women underwent surgical staging for preoperative stage I endometrial cancer were revised (145 Monza; 657 Rome)...
December 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28968296/sentinel-lymph-node-ultra-staging-as-a-supplement-for-endometrial-cancer-intraoperative-frozen-section-deficiencies
#16
Morgan Blakely, Yuxin Liu, Jamal Rahaman, Monica Prasad-Hayes, Mikhail Tismenetsky, Xiaofei Wang, Navya Nair, Karen A Dresser, Nimesh Nagarsheth, Tamara Kalir
For endometrial cancer (EC), most surgeons rely on intraoperative frozen section (IFS) to determine the risk of nodal metastasis and necessity of lymphadenectomy. IFS remains a weak link in this practice due to its susceptibility to diagnostic errors. As a less invasive alternative, sentinel lymph node (SLN) mapping and ultra-staging have gradually gained acceptance for EC. We aimed to establish the SLN success rate, negative predictive value, and whether SLNs provide useful information for cases misdiagnosed on IFS...
September 29, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28965698/comparison-of-a-sentinel-lymph-node-mapping-algorithm-and-comprehensive-lymphadenectomy-in-the-detection-of-stage-iiic-endometrial-carcinoma-at-higher-risk-for-nodal-disease
#17
Jennifer A Ducie, Ane Gerda Zahl Eriksson, Narisha Ali, Michaela E McGree, Amy L Weaver, Giorgio Bogani, William A Cliby, Sean C Dowdy, Jamie N Bakkum-Gamez, Robert A Soslow, Gary L Keeney, Nadeem R Abu-Rustum, Andrea Mariani, Mario M Leitao
OBJECTIVE: To determine if a sentinel lymph node (SLN) mapping algorithm will detect metastatic nodal disease in patients with intermediate-/high-risk endometrial carcinoma. METHODS: Patients were identified and surgically staged at two collaborating institutions. The historical cohort (2004-2008) at one institution included patients undergoing complete pelvic and paraaortic lymphadenectomy to the renal veins (LND cohort). At the second institution an SLN mapping algorithm, including pathologic ultra-staging, was performed (2006-2013) (SLN cohort)...
December 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28954449/-clinical-analysis-of-76-cases-of-sentinel-lymph-node-detection-in-cervical-cancer-and-endometrial-cancer
#18
S C Liang, Z Q Wang, J L Wang
Objective: To evaluate the feasibility and clinical value of identifying sentinel lymph node (SLN) and to assess possible factors associated with detection rate in both cervical cancer and endometrial cancer. Methods: Retrospective study of 76 cases (39 with cervical cancer and 37 with endometrial cancer) were conducted in Peking University People's Hospital. All patients underwent SLN biopsy with tracers of indocyanine green (ICG) and (or) carbon nanoparticles. All mapped SLN was resected and followed by procedures that systematic pelvic lymphadenectomy and hysterectomy according to National Comprehensive Cancer Network (NCCN) guidelines...
September 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28942993/performance-of-sentinel-lymph-node-sln-mapping-in-high-risk-endometrial-cancer
#19
Omar Touhami, Jean Grégoire, Marie-Claude Renaud, Alexandra Sebastianelli, Marie Plante
OBJECTIVE: While the accuracy of the SLN procedure has been validated in patients with low risk EC, its relevance for high-risk EC remains debated. The aim of this study was to evaluate the accuracy of SLN mapping in patients with high-risk EC. STUDY METHOD: We reviewed all patients with high risk EC (grade 3 endometrioid, serous, carcinosarcoma, clear cell and undifferentiated) who underwent primary surgery with SLN mapping followed by pelvic +/- paraaortic lymphadenectomy, between November 2010 and November 2016...
September 21, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28939481/laparoscopic-typical-and-atypical-locations-of-sentinel-node-mapping-with-indocyanine-green-comparison-of-2-near-infrared-fluorescence-systems
#20
Giampaolo Di Martino, Claudio Reato, Debora Verri, Federica Dell'Orto, Alessandro Buda
STUDY OBJECTIVE: To present our minimally invasive laparoscopic approach for sentinel lymph node (SLN) mapping with indocyanine green (ICG) using 2 fluorescence systems. DESIGN: A step-by-step video description of the technique showing the most frequent typical and atypical location of SLNs (educational video). SETTING: Lymph node staging in apparent confined endometrial cancer. PATIENTS: Women underwent SLN mapping in a minimally invasive setting...
September 20, 2017: Journal of Minimally Invasive Gynecology
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