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Sentinel node endometrial cancer

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https://www.readbyqxmd.com/read/27871836/sentinel-lymph-node-assessment-in-endometrial-cancer-a-systematic-review-and-meta-analysis
#1
REVIEW
Anna Jo Bodurtha Smith, Amanda Nickles Fader, Edward J Tanner
BACKGROUND: In the staging of endometrial cancer, controversy remains regarding the role of sentinel lymph node mapping compared with other nodal assessment strategies. OBJECTIVE: We conducted a systematic review to evaluate the diagnostic accuracy and clinical impact of sentinel lymph node mapping in the management of endometrial cancer. DATA SOURCES: We searched Medline, Embase, and the Cochrane Central Registry of Controlled trials for studies published in English before March 25, 2016 (PROSPERO CRD42016036503)...
November 18, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27864117/microcystic-elongated-and-fragmented-melf-pattern-invasion-is-mainly-associated-with-isolated-tumor-cell-pattern-metastases-in-figo-grade-i-endometrioid-endometrial-cancer-eec
#2
Mathieu P Pelletier, Vincent Q Trinh, Philippe Stephenson, Anne-Marie Mes-Masson, Vanessa Samouelian, Diane M Provencher, Kurosh Rahimi
While many studies have evaluated the impact of mismatch repair protein loss of expression (MMR LOE) or microcystic, elongated and fragmented (MELF) pattern of myometrial invasion as individual factors in endometrial cancer, we analyzed the combined impact of both. We reviewed every case of FIGO grade 1 endometrioid endometrial cancers (EEC) from our institution, between 2011 and 2015, that had a sentinel lymph node biopsy and/or a lymphadenectomy, and examined the following data: age, myometrial infiltration, MELF infiltration, lymphovascular space invasion and lymph node status...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27834005/figo-stage-iiic-endometrial-cancer-identification-among-patients-with-complex-atypical-hyperplasia-grade-1-and-2-endometrioid-endometrial-cancer-laparoscopic-indocyanine-green-sentinel-lymph-node-mapping-versus-frozen-section-of-the-uterus-why-get-around-the
#3
Andrea Papadia, Maria Luisa Gasparri, Franziska Siegenthaler, Sara Imboden, Stefan Mohr, Michael D Mueller
PURPOSE: To compare two surgical strategies used to identify lymph node metastases in patients with preoperative diagnosis of complex atypical hyperplasia (CAH), grade 1 and 2 endometrial cancer (EC). METHODS: Data on patients with preoperative diagnosis of CAH, grade 1 and 2 EC undergoing laparoscopic indocyanine green (ICG) sentinel lymph node (SLN) mapping followed by frozen section of the uterus were collected. When risk factors were identified at frozen section, patients were subjected to a systematic lymphadenectomy...
November 11, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27815812/sentinel-node-mapping-in-endometrial-cancer-patients-comparing-spect-ct-gamma-probe-and-dye
#4
Federica Elisei, Cinzia Crivellaro, Daniela Giuliani, Carlotta Dolci, Elena De Ponti, Luca Montanelli, Maria La Manna, Luca Guerra, Maurizio Arosio, Claudio Landoni, Alessandro Buda
OBJECTIVE: The aim of this study was to compare preoperative SPECT/CT with gamma-probe and methylene blue-dye (MBD) in the identification of sentinel lymph node (SLN) in early stage endometrial cancer. METHODS: 40 stage-I EC patients (66.7 ± 9.7 years) underwent preoperative lymphoscintigraphy. After about 3 h from Tc-99m-albumin nanocolloid cervical injection, all patients underwent SPECT/CT study. MBD was injected into the cervix just before surgery under general anesthesia...
November 4, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27815041/feasibility-of-robotic-assisted-laparoendoscopic-single-site-surgery-in-the-gynecologic-oncology-setting
#5
Lea A Moukarzel, Amanda N Fader, Edward J Tanner
STUDY OBJECTIVE: To assess the feasibility of incorporating robotic laparoendoscopic single-site (R-LESS) surgery into gynecologic oncology care. DESIGN: Retrospective study (Canadian Task Force classification II-3). SETTING: Academic university hospital. PATIENTS: Patients undergoing R-LESS hysterectomy for gynecologic malignancies, preinvasive disease, or risk reduction performed by a single gynecologic oncologist between 2014 and 2016...
November 1, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27812854/sentinel-lymph-node-mapping-in-patients-with-stage-i-endometrial-carcinoma-a-focus-on-bilateral-mapping-identification-by-comparing-radiotracer-tc99-m-with-blue-dye-versus-indocyanine-green-fluorescent-dye
#6
Andrea Papadia, Ignacio Zapardiel, Beatrice Bussi, Fabio Ghezzi, Marcello Ceccaroni, Elena De Ponti, Federica Elisei, Sara Imboden, Begoña Diaz de la Noval, Maria Luisa Gasparri, Giampaolo Di Martino, Javier De Santiago, Michael Mueller, Francesca Vecchione, Federica Dell'Orto, Alessandro Buda
PURPOSE: The aim of this study was to compare technetium radiocolloid (Tc99(m)) + blue dye (BD) versus Indocyanine green (ICG) fluorescent dye in terms of the overall detection rate and bilateral sentinel lymph node (SLN) mapping in patients with endometrial carcinoma. METHODS: Patients from five European centers with apparently confined clinical stage I endometrial cancer were reviewed. A comparison was made between women who received SLN mapping with pelvic and/or aortic lymphadenectomy (LND), and women who underwent SLN algorithm (SA), was also performed between the two groups...
November 3, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27776838/indocyanine-green-fluorescence-imaging-of-lymph-nodes-during-robotic-assisted-laparoscopic-operation-for-endometrial-cancer-a-prospective-validation-study-using-a-sentinel-lymph-node-surgical-algorithm
#7
Bjørn Hagen, Marit Valla, Guro Aune, Merethe Ravlo, Anne Britt Abusland, Elisabeth Araya, Marit Sundset, Solveig Tingulstad
OBJECTIVE: A sentinel lymph node (SLN) strategy may have particular value in endometrial cancer (EC) because a therapeutic effect of lymphadenectomy per se is unproven. The aim was to evaluate indocyanine green (ICG) and near-infrared (NIR) fluorescence mapping using a surgical algorithm. METHODS: From November 2012 through December 2015, women with apparently early stage EC underwent robot-assisted laparoscopic hysterectomy including ICG fluorescence SLN mapping following the Memorial Sloane Kettering Cancer Center (MSKCC) surgical algorithm...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27757531/-metastatic-mechanisms-of-uterine-malignancies-and-therapeutic-consequences
#8
S F Lax, K F Tamussino, P F Lang
Malignancies of the uterus metastasize by direct invasion of neighboring structures, lymphatically or hematogenously. Endometrial and cervical cancers lymphatically spread to the pelvic and para-aortic lymph nodes. For endometrial cancer the depth of myometrial invasion, lymphosvascular space involvement (LVSI) and a microcystic, elongated and fragmented (MELF) glandular invasion pattern are predictors for lymph node metastases. Metastases to the pelvic lymph nodes occur in approximately 10 % of endometrial cancer patients and in 30 % of these cases the para-aortic lymph nodes are also involved...
October 18, 2016: Der Pathologe
https://www.readbyqxmd.com/read/27750179/indocyanine-green-and-infrared-fluorescence-in-detection-of-sentinel-lymph-nodes-in-endometrial-and-cervical-cancer-staging-a-systematic-review
#9
Anabela Rocha, Ana Maria Domínguez, Fabrice Lécuru, Nicolas Bourdel
OBJECTIVE: Sentinel lymph node (SLN) mapping for endometrial (EC) and cervical cancers (CC) is a current technique that could provide benefits over traditional lymphadenectomy. Near-infrared (NIR) fluorescence imaging is a promising technique to perform this procedure. We conducted a systematic review of the evidence regarding the technique and the effectiveness of indocyanine green (ICG) during SLN biopsy, using robotic and laparoscopic assisted surgery and laparotomy. MATERIALS AND METHODS: We conducted a computer literature search for published English language studies in humans using PubMed since January 2010 up to May 2015...
September 30, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27749429/pericervical-injection-of-99mtc-nanocolloid-is-superior-to-peritumoral-injection-for-sentinel-lymph-node-detection-of-endometrial-cancer-in-spect-ct
#10
Samine Sahbai, Florin-Andrei Taran, Francesco Fiz, Annette Staebler, Sven Becker, Erich Solomayer, Diethelm Wallwiener, Christian la Fougère, Sara Brucker, Helmut Dittmann
PURPOSE: Scintigraphic mapping of sentinel lymph node (SLN) is increasingly performed in patients with endometrial carcinoma although its routine clinical use is still under investigation. The purpose of this study was to compare preoperative SLN detection by means of SPECT/CT using pericervical (PC) versus hysteroscopic peritumoral (PT) injection. PATIENTS AND METHODS: One hundred forty consecutive patients with endometrial carcinoma who underwent surgery and preoperative SLN SPECT/CT with Tc-nanocolloid were included...
October 5, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27745919/fluorescence-assisted-sentinel-snd-and-pelvic-node-dissections-by-single-port-transvaginal-laparoscopic-surgery-for-the-management-of-an-endometrial-carcinoma-ec-in-an-elderly-obese-patient
#11
Eric Leblanc, Fabrice Narducci, Lucie Bresson, Delphine Hudry
OBJECTIVE: To explore the feasibility of an oncologically acceptable management for an intermediate-risk endometrial cancer (EC) in an elderly, using the combination of transvaginal single-port laparoscopy and sentinel node policy. METHODS: For this 85-years old patient, BMI 32kg/m(2), with IB grade 2 endometrioid EC, a single vaginal approach was attempted [1] to perform a total hysterectomy, bilateral salpinago-oophorectomy and pelvic node assessment guided by SND [2]...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27738629/the-sentinel-node-approach-in-gynaecological-malignancies
#12
Angela Collarino, Sergi Vidal-Sicart, Germano Perotti, Renato A Valdés Olmos
This review discusses the state-of-the-art of sentinel lymph node mapping in gynaecological malignancies, including cervical cancer, endometrial cancer, and vulvar cancer, with an emphasis on new technological advances. For this objective, PubMed/MEDLINE was searched for relevant studies about the sentinel lymph node procedure in gynaecology. In particular, the use of preoperative lymphatic mapping with lymphoscintigraphy and single photon emission tomography/computed tomography (SPECT/CT) was identified in 18 studies...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27738006/comparison-of-intra-operative-gamma-probe-detection-with-postoperative-spect-ct-of-sentinel-nodes-related-to-the-ovary
#13
Stephanie C J M Speth, Roy F P M Kruitwagen, Marjolein Kleppe, Ivo N A Pooters, Toon Van Gorp, Brigitte F M Slangen, Boudewijn Brans
PURPOSE: Tracer injection into ovarian ligaments has been shown to detect sentinel nodes (SNs) in patients with ovarian cancer. To determine the possibility that SNs are missed, this feasibility study compared their detection during surgery with postoperative SPECT/CT. METHODS: In eight patients (either ovarian or endometrial cancer), after a staging lymphadenectomy including resection of SNs related to the ovary, SPECT/CT scans were performed within 24 hours. RESULTS: SPECT/CT identified hotspots in four patients at sites where SNs were resected...
October 13, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27725278/laparoscopic-sentinel-node-mapping-in-endometrial-cancer-after-hysteroscopic-injection-of-indocyanine-green
#14
Fabio Martinelli, Antonino Ditto, Giorgio Bogani, Mauro Signorelli, Valentina Chiappa, Domenica Lorusso, Edward Haeusler, Francesco Raspagliesi
STUDY OBJECTIVE: To report the detection rate (DR) of sentinel lymph nodes (SLNs) in endometrial cancer (EC) patients after hysteroscopic injection of indocyanine green (ICG) and laparoscopic near-infrared (L-NIR) fluorescence mapping. DESIGN: Prospectively collected data (Canadian Task Force classification II-2). SETTING: Gynecologic oncology referral center. PATIENTS: Consecutive patients with apparent early-stage endometrioid EC scheduled for surgical treatment: total laparoscopic hysterectomy, bilateral salpingo-oophorectomy, SLN mapping...
October 8, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27679230/sentinel-node-mapping-in-endometrial-cancer-by-using-hysteroscopic-injection-of-indocyanine-green-and-laparoscopic-near-infrared-fluorescence-imaging-a-preliminary-experience
#15
F Martinelli, A Ditto, G Bogani, V Chiappa, D Lorusso, F Raspagliesi
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27679151/detection-of-sentinel-lymph-node-mapping-using-indocyanine-green-in-the-management-of-endometrial-cancer-a-pilot-study
#16
C-H Chen, H-H Chen, W-M Liu
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27670732/near-infrared-fluorescence-guided-sentinel-node-mapping-of-the-ovary-with-indocyanine-green-in-a-minimally-invasive-setting-a-feasible-study
#17
Alessandro Buda, Paolo Passoni, Giacomo Corrado, Beatrice Bussi, Giuseppe Cutillo, Sonia Magni, Enrico Vizza
Sentinel lymph node (SLN) mapping has increased its feasibility in both early stage cervical and endometrial cancer. There are few SLN studies regarding the ovary, because of the risk of tumor dissemination and perhaps because the ovary represents an inconvenient site for injection. In this preliminary study, we have shown the feasibility of SLN mapping of the ovary with Indocyanine green (ICG) during laparoscopic retroperitoneal aortic surgical staging. The ten women who were included in this study underwent aortic with pelvic laparoscopic staging, which included SLN biopsy, extrafascial total hysterectomy and bilateral salpingo-oophorectomy in case of ovarian tumor...
September 23, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27667001/-18-f-fdg-pet-ct-and-sentinel-lymph-node-biopsy-in-the-staging-of-patients-with-cervical-and-endometrial-cancer-role-of-dual-time-point-imaging
#18
M Mayoral, P Paredes, B Domènech, P Fusté, S Vidal-Sicart, A Tapias, A Torné, J Pahisa, J Ordi, F Pons, F Lomeña
OBJECTIVE: Definitive staging for cervical (CC) and endometrial cancer (EC) takes place once surgery is performed. The aim of this study was to evaluate the role of PET/CT in detecting lymphatic metastasis in patients with CC and EC using dual-time-point imaging (DPI), taking the histopathological results of sentinel lymph node (SLN) and lymphadenectomy as the reference. MATERIAL AND METHODS: A prospective study was conducted on 17 patients with early CC, and 13 patients with high-risk EC...
September 22, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/27643647/the-combination-of-preoperative-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-and-sentinel-lymph-node-mapping-in-the-surgical-management-of-endometrioid-endometrial-cancer
#19
Tugan Bese, Veysel Sal, Fuat Demirkiran, Ilker Kahramanoglu, Nedim Tokgozoglu, Sennur Ilvan, Ovgu Aydin, Metin Hallac, Betul Vatankulu, Gokhan Demirayak, Hasan Turan, Macit Arvas
OBJECTIVE: The goal of this study was to evaluate the combination of sentinel lymph node (SLN) mapping and F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) scan in detection of lymph node involvement in patients with endometrioid endometrial cancer (EEC). METHODS/MATERIALS: Ninety-five patients with EEC who had preoperative PET/CT imaging and underwent SLN mapping were retrospectively analyzed. Methylene blue dye was used and injected to the cervix at 3- and 9-o'clock positions (a total of 4 mL)...
September 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27568279/reducing-overtreatment-a-comparison-of-lymph-node-assessment-strategies-for-endometrial-cancer
#20
Abdulrahman K Sinno, Elizabeth Peijnenburg, Amanda N Fader, Sarah M Temkin, Rebecca Stone, Kimberly Levinson, Tricia Murdock, Edward J Tanner
OBJECTIVES: To compare the utility of three lymph node (LN) assessment strategies to identify lymphatic metastases while minimizing complete lymphadenectomy rates in women with low-grade endometrial cancer (EC). METHODS: Using our institutional standard protocol (SP), patients with complex atypical hyperplasia (CAH) or grade 1/2 EC underwent sentinel lymph node (SLN) mapping, hysterectomy, and intraoperative frozen section (FS). Lymphadenectomy was performed if high-risk uterine features were identified on FS...
August 24, 2016: Gynecologic Oncology
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