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Sentinel node endometrial cancer

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https://www.readbyqxmd.com/read/28224135/aortic-utero-ovarian-sentinel-nodes-and-left-infrarenal-aortic-lymph-node-dissection-by-icg-supported-navigation
#1
Rainer Kimmig, Peter Rusch, Paul Buderath, Bahriye Aktas
•Visualization of paraaortic sentinel compartments in endometrial cancer•Nerve sparing dissection of left paraaortic infrarenal lymph compartment•Educational video may be basis for standardization of paraaortic sentinel node dissection.
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28213057/utilization-of-sentinel-lymph-node-biopsy-for-uterine-cancer
#2
Jason D Wright, Stephanie Cham, Ling Chen, William M Burke, June Y Hou, Ana I Tergas, Vrunda Desai, Jim C Hu, Cande V Ananth, Alfred I Neugut, Dawn L Hershman
BACKGROUND: To limit the potential short and long-term morbidity of lymphadenectomy, sentinel lymph node (SLN) biopsy has been proposed for endometrial cancer. The principle of SLN biopsy relies on removal of a small number of lymph nodes that are the first drainage basins from a tumor and thus the most likely to harbor tumor cells. While the procedure may reduce morbidity, efficacy data is limited and little is known about how commonly the procedure is performed. OBJECTIVE: We examined the patterns and predictors of use of SLN biopsy and outcomes of the procedure in women with endometrial cancer who underwent hysterectomy...
February 14, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28196672/a-study-on-uterine-lymphatic-anatomy-for-standardization-of-pelvic-sentinel-lymph-node-detection-in-endometrial-cancer
#3
Barbara Geppert, Céline Lönnerfors, Michele Bollino, Anastasija Arechvo, Jan Persson
OBJECTIVE: To describe the anatomy of uterine lymphatic drainage following cervical or fundal tracer injection to enable standardization of a pelvic sentinel lymph node (SLN) concept in endometrial cancer (EC). METHODS: A prospective consecutive study of women with EC was conducted. A fluorescent dye (Indocyanine green) was injected into the cervix (n=60) or the uterine fundus (n=30). A systematic trans- and retroperitoneal mapping of uterine lymphatic drainage was performed...
February 10, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28159465/a-comparison-of-sentinel-lymph-node-biopsy-to-lymphadenectomy-for-endometrial-cancer-staging-fires-trial-a-multicentre-prospective-cohort-study
#4
Emma C Rossi, Lynn D Kowalski, Jennifer Scalici, Leigh Cantrell, Kevin Schuler, Rabbie K Hanna, Michael Method, Melissa Ade, Anastasia Ivanova, John F Boggess
BACKGROUND: Sentinel-lymph-node mapping has been advocated as an alternative staging technique for endometrial cancer. The aim of this study was to measure the sensitivity and negative predictive value of sentinel-lymph-node mapping compared with the gold standard of complete lymphadenectomy in detecting metastatic disease for endometrial cancer. METHODS: In the FIRES multicentre, prospective, cohort study patients with clinical stage 1 endometrial cancer of all histologies and grades undergoing robotic staging were eligible for study inclusion...
January 31, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28159464/sentinel-lymph-node-mapping-in-endometrial-cancer-routine-practice
#5
Frédéric Amant, Hans Trum
No abstract text is available yet for this article.
January 31, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28104296/impact-of-sentinel-lymph-node-mapping-on-recurrence-patterns-in-endometrial-cancer
#6
Jeffrey How, Caroline Gauthier, Jeremie Abitbol, Susie Lau, Shannon Salvador, Raphael Gotlieb, Manuela Pelmus, Alex Ferenczy, Stephan Probst, Sonya Brin, Asma Fatnassi, Walter Gotlieb
BACKGROUND: Sentinel lymph node (SLN) mapping has emerged as a promising solution to the ongoing debate regarding lymphadenectomy in the initial surgical management of endometrial cancer. Currently, little is known about its possible impact on location of disease recurrence compared to systematic lymphadenectomy. METHODS: In this retrospective study, 472 consecutive patients with endometrial cancer who underwent either SLN mapping (SLN cohort, n=275) or systematic lymphadenectomy (LND cohort, n=197) from sequential, non-overlapping historical time points were compared...
January 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28058558/call-for-surgical-nodal-staging-in-women-with-esmo-esgo-estro-high-intermediate-risk-endometrial-cancer-a-multicentre-cohort-analysis-from-the-francogyn-study-group
#7
L Ouldamer, S Bendifallah, G Body, G Canlorbe, C Touboul, O Graesslin, E Raimond, P Collinet, C Coutant, V Lavoué, J Lévêque, E Daraï, M Ballester
BACKGROUND: The European Society of Medical Oncology (ESMO)/European Society of Gynaecological Oncology (ESGO)/European Society for Radiotherapy & Oncology (ESTRO) classification for endometrial cancer (EC) now includes a high-intermediate risk (HIR) group of recurrence due to the adverse prognostic role of lymphovascular space involvement (LVSI) and grade 3 for women at intermediate risk. However, optimal surgical staging, and especially the place of lymphadenectomy, remains to be elucidated...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28035487/application-of-sentinel-lymph-node-dissection-in-gynecological-cancers-results-of-a-survey-among-german-hospitals
#8
Rüdiger Klapdor, Hermann Hertel, Philipp Soergel, Matthias Jentschke, Peter Hillemanns
PURPOSE: Evaluating the application of the sentinel lymph node dissection (SLND) in gynecological cancers among German hospitals. METHODS: Between March and June 2016 an online questionnaire on SLND in gynecologic cancers was sent by email to all German gynecologic cancer centers, all university hospitals and general hospitals for which an email address was available. The survey contained 61 questions regarding the SLND in vulvar, cervical, endometrial and ovarian cancer...
December 29, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27871836/sentinel-lymph-node-assessment-in-endometrial-cancer-a-systematic-review-and-meta-analysis
#9
REVIEW
Anna Jo Bodurtha Smith, Amanda Nickles Fader, Edward J Tanner
BACKGROUND: In the staging of endometrial cancer, controversy remains regarding the role of sentinel lymph node mapping compared with other nodal assessment strategies. OBJECTIVE: We conducted a systematic review to evaluate the diagnostic accuracy and clinical impact of sentinel lymph node mapping in the management of endometrial cancer. DATA SOURCES: We searched Medline, Embase, and the Cochrane Central Registry of Controlled trials for studies published in English before March 25, 2016 (PROSPERO CRD42016036503)...
November 18, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27864117/microcystic-elongated-and-fragmented-melf-pattern-invasion-is-mainly-associated-with-isolated-tumor-cell-pattern-metastases-in-figo-grade-i-endometrioid-endometrial-cancer-eec
#10
Mathieu P Pelletier, Vincent Q Trinh, Philippe Stephenson, Anne-Marie Mes-Masson, Vanessa Samouelian, Diane M Provencher, Kurosh Rahimi
While many studies have evaluated the impact of mismatch repair protein loss of expression (MMR LOE) or microcystic, elongated and fragmented (MELF) pattern of myometrial invasion as individual factors in endometrial cancer, we analyzed the combined impact of both. We reviewed every case of FIGO grade 1 endometrioid endometrial cancers (EEC) from our institution, between 2011 and 2015, that had a sentinel lymph node biopsy and/or a lymphadenectomy, and examined the following data: age, myometrial infiltration, MELF infiltration, lymphovascular space invasion and lymph node status...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27834005/figo-stage-iiic-endometrial-cancer-identification-among-patients-with-complex-atypical-hyperplasia-grade-1-and-2-endometrioid-endometrial-cancer-laparoscopic-indocyanine-green-sentinel-lymph-node-mapping-versus-frozen-section-of-the-uterus-why-get-around-the
#11
Andrea Papadia, Maria Luisa Gasparri, Franziska Siegenthaler, Sara Imboden, Stefan Mohr, Michael D Mueller
PURPOSE: To compare two surgical strategies used to identify lymph node metastases in patients with preoperative diagnosis of complex atypical hyperplasia (CAH), grade 1 and 2 endometrial cancer (EC). METHODS: Data on patients with preoperative diagnosis of CAH, grade 1 and 2 EC undergoing laparoscopic indocyanine green (ICG) sentinel lymph node (SLN) mapping followed by frozen section of the uterus were collected. When risk factors were identified at frozen section, patients were subjected to a systematic lymphadenectomy...
March 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27815812/sentinel-node-mapping-in-endometrial-cancer-patients-comparing-spect-ct-gamma-probe-and-dye
#12
COMPARATIVE STUDY
Federica Elisei, Cinzia Crivellaro, Daniela Giuliani, Carlotta Dolci, Elena De Ponti, Luca Montanelli, Maria La Manna, Luca Guerra, Maurizio Arosio, Claudio Landoni, Alessandro Buda
OBJECTIVE: The aim of this study was to compare preoperative SPECT/CT with gamma-probe and methylene blue-dye (MBD) in the identification of sentinel lymph node (SLN) in early stage endometrial cancer. METHODS: 40 stage-I EC patients (66.7 ± 9.7 years) underwent preoperative lymphoscintigraphy. After about 3 h from Tc-99m-albumin nanocolloid cervical injection, all patients underwent SPECT/CT study. MBD was injected into the cervix just before surgery under general anesthesia...
January 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27815041/feasibility-of-robotic-assisted-laparoendoscopic-single-site-surgery-in-the-gynecologic-oncology-setting
#13
Lea A Moukarzel, Amanda N Fader, Edward J Tanner
STUDY OBJECTIVE: To assess the feasibility of incorporating robotic laparoendoscopic single-site (R-LESS) surgery into gynecologic oncology care. DESIGN: Retrospective study (Canadian Task Force classification II-3). SETTING: Academic university hospital. PATIENTS: Patients undergoing R-LESS hysterectomy for gynecologic malignancies, preinvasive disease, or risk reduction performed by a single gynecologic oncologist between 2014 and 2016...
November 1, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27812854/sentinel-lymph-node-mapping-in-patients-with-stage-i-endometrial-carcinoma-a-focus-on-bilateral-mapping-identification-by-comparing-radiotracer-tc99-m-with-blue-dye-versus-indocyanine-green-fluorescent-dye
#14
Andrea Papadia, Ignacio Zapardiel, Beatrice Bussi, Fabio Ghezzi, Marcello Ceccaroni, Elena De Ponti, Federica Elisei, Sara Imboden, Begoña Diaz de la Noval, Maria Luisa Gasparri, Giampaolo Di Martino, Javier De Santiago, Michael Mueller, Francesca Vecchione, Federica Dell'Orto, Alessandro Buda
PURPOSE: The aim of this study was to compare technetium radiocolloid (Tc99(m)) + blue dye (BD) versus Indocyanine green (ICG) fluorescent dye in terms of the overall detection rate and bilateral sentinel lymph node (SLN) mapping in patients with endometrial carcinoma. METHODS: Patients from five European centers with apparently confined clinical stage I endometrial cancer were reviewed. A comparison was made between women who received SLN mapping with pelvic and/or aortic lymphadenectomy (LND), and women who underwent SLN algorithm (SA), was also performed between the two groups...
March 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27776838/indocyanine-green-fluorescence-imaging-of-lymph-nodes-during-robotic-assisted-laparoscopic-operation-for-endometrial-cancer-a-prospective-validation-study-using-a-sentinel-lymph-node-surgical-algorithm
#15
Bjørn Hagen, Marit Valla, Guro Aune, Merethe Ravlo, Anne Britt Abusland, Elisabeth Araya, Marit Sundset, Solveig Tingulstad
OBJECTIVE: A sentinel lymph node (SLN) strategy may have particular value in endometrial cancer (EC) because a therapeutic effect of lymphadenectomy per se is unproven. The aim was to evaluate indocyanine green (ICG) and near-infrared (NIR) fluorescence mapping using a surgical algorithm. METHODS: From November 2012 through December 2015, women with apparently early stage EC underwent robot-assisted laparoscopic hysterectomy including ICG fluorescence SLN mapping following the Memorial Sloane Kettering Cancer Center (MSKCC) surgical algorithm...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27757531/-metastatic-mechanisms-of-uterine-malignancies-and-therapeutic-consequences
#16
S F Lax, K F Tamussino, P F Lang
Malignancies of the uterus metastasize by direct invasion of neighboring structures, lymphatically or hematogenously. Endometrial and cervical cancers lymphatically spread to the pelvic and para-aortic lymph nodes. For endometrial cancer the depth of myometrial invasion, lymphosvascular space involvement (LVSI) and a microcystic, elongated and fragmented (MELF) glandular invasion pattern are predictors for lymph node metastases. Metastases to the pelvic lymph nodes occur in approximately 10 % of endometrial cancer patients and in 30 % of these cases the para-aortic lymph nodes are also involved...
November 2016: Der Pathologe
https://www.readbyqxmd.com/read/27750179/indocyanine-green-and-infrared-fluorescence-in-detection-of-sentinel-lymph-nodes-in-endometrial-and-cervical-cancer-staging-a-systematic-review
#17
Anabela Rocha, Ana Maria Domínguez, Fabrice Lécuru, Nicolas Bourdel
OBJECTIVE: Sentinel lymph node (SLN) mapping for endometrial (EC) and cervical cancers (CC) is a current technique that could provide benefits over traditional lymphadenectomy. Near-infrared (NIR) fluorescence imaging is a promising technique to perform this procedure. We conducted a systematic review of the evidence regarding the technique and the effectiveness of indocyanine green (ICG) during SLN biopsy, using robotic and laparoscopic assisted surgery and laparotomy. MATERIALS AND METHODS: We conducted a computer literature search for published English language studies in humans using PubMed since January 2010 up to May 2015...
November 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27749429/pericervical-injection-of-99mtc-nanocolloid-is-superior-to-peritumoral-injection-for-sentinel-lymph-node-detection-of-endometrial-cancer-in-spect-ct
#18
Samine Sahbai, Florin-Andrei Taran, Francesco Fiz, Annette Staebler, Sven Becker, Erich Solomayer, Diethelm Wallwiener, Christian la Fougère, Sara Brucker, Helmut Dittmann
PURPOSE: Scintigraphic mapping of sentinel lymph node (SLN) is increasingly performed in patients with endometrial carcinoma although its routine clinical use is still under investigation. The purpose of this study was to compare preoperative SLN detection by means of SPECT/CT using pericervical (PC) versus hysteroscopic peritumoral (PT) injection. PATIENTS AND METHODS: One hundred forty consecutive patients with endometrial carcinoma who underwent surgery and preoperative SLN SPECT/CT with Tc-nanocolloid were included...
December 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27745919/fluorescence-assisted-sentinel-snd-and-pelvic-node-dissections-by-single-port-transvaginal-laparoscopic-surgery-for-the-management-of-an-endometrial-carcinoma-ec-in-an-elderly-obese-patient
#19
Eric Leblanc, Fabrice Narducci, Lucie Bresson, Delphine Hudry
OBJECTIVE: To explore the feasibility of an oncologically acceptable management for an intermediate-risk endometrial cancer (EC) in an elderly, using the combination of transvaginal single-port laparoscopy and sentinel node policy. METHODS: For this 85-years old patient, BMI 32kg/m(2), with IB grade 2 endometrioid EC, a single vaginal approach was attempted [1] to perform a total hysterectomy, bilateral salpinago-oophorectomy and pelvic node assessment guided by SND [2]...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27738629/the-sentinel-node-approach-in-gynaecological-malignancies
#20
Angela Collarino, Sergi Vidal-Sicart, Germano Perotti, Renato A Valdés Olmos
This review discusses the state-of-the-art of sentinel lymph node mapping in gynaecological malignancies, including cervical cancer, endometrial cancer, and vulvar cancer, with an emphasis on new technological advances. For this objective, PubMed/MEDLINE was searched for relevant studies about the sentinel lymph node procedure in gynaecology. In particular, the use of preoperative lymphatic mapping with lymphoscintigraphy and single photon emission tomography/computed tomography (SPECT/CT) was identified in 18 studies...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
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