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Pancreatic cancer cell, microRNA

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https://www.readbyqxmd.com/read/29145206/microrna-expression-profiling-of-pancreatic-cancer-cell-line-l3-6p1-following-b7-h4-knockdown
#1
Yun Qian, Limin Feng, Weigen Wu, Tianhao Weng, Chenyu Hu, Bo Hong, Frederick X C Wang, Lingwei Shen, Qi Wang, Xin Jin, Hangping Yao
BACKGROUND/AIMS: Co-stimulating molecule B7-H4 regulates T cell-mediated immune responses, participates in tumor immune escape, and promotes the proliferation and metastasis of pancreatic cancer cells. However, the specific mechanisms are unclear. MicroRNAs (miRNAs) participated in the pathogenesis and progression of cancer. METHODS: In this study, a microarray technique was used to screen B7-H4-related differentially expressed miRNAs in a pancreatic cancer cell line find those associated with pancreatic cancer...
November 17, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29141872/mir-23a-acts-as-an-oncogene-in-pancreatic-carcinoma-by-targeting-foxp2
#2
Hongliang Diao, Zhou Ye, Renyi Qin
MicroRNAs have been reported to play an important role in tumor development and progression by targeting oncogenes and tumor suppressors. miR-23a has been described as significantly upregulated in multiple cancers and involved in tumorigenesis. The aim of this study was to evaluate the potential roles of miR-23a in pancreatic ductal adenocarcinoma (PDAC). We found that miR-23a level was significantly increased in tissues of PDAC compared with that in the control by real-time PCR. FOXP2 expression was downregulated and inversely correlated with miR-23a...
November 14, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29137308/microrna-23a-promotes-pancreatic-cancer-metastasis-by-targeting-epithelial-splicing-regulator-protein-1
#3
Guo Wu, Zhonghu Li, Peng Jiang, Xi Zhang, Yingqiang Xu, Kai Chen, Xiaowu Li
miR-23a plays vital roles in various cancer metastases. Here, we found that miR-23a expression was significantly up-regulated in pancreatic cancer tissues compared with adjacent normal tissues. miR-23a up-regulation was significantly associated with differentiated degree, lymphoid nodal status, tumor invasion and poor survival rate in pancreatic cancer patients. We also found that miR-23a expression was significantly up-regulated in lymph node metastatic tissues and in pancreatic cancer cells that underwent epithelial-mesenchymal transition (EMT)...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137251/exportin-1-xpo1-inhibition-leads-to-restoration-of-tumor-suppressor-mir-145-and-consequent-suppression-of-pancreatic-cancer-cell-proliferation-and-migration
#4
Asfar S Azmi, Yiwei Li, Irfana Muqbil, Amro Aboukameel, William Senapedis, Erkan Baloglu, Yosef Landesman, Sharon Shacham, Michael G Kauffman, Philip A Philip, Ramzi M Mohammad
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer related deaths in the United States with a majority of these patients dying from aggressively invasive and metastatic disease. There is growing evidence that suggests an important role for microRNAs (miRNAs) in the pathobiology of aggressive PDAC. In this study, we found that the expression of miR-145 was significantly lower in PDAC cells when compared to normal pancreatic duct epithelial cells. Here we show that inhibition of the nuclear exporter protein exportin 1 (XPO1; also known as chromosome maintenance region 1 [CRM1]) by siRNA knockdown or by the Selective Inhibitor of Nuclear Export (SINE) compound (KPT-330; selinexor) increases miR-145 expression in PDAC cells resulting in the decreased cell proliferation and migration capacities...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29120411/alternative-polyadenylation-of-zeb1-promotes-its-translation-during-genotoxic-stress-in-pancreatic-cancer-cells
#5
Ilaria Passacantilli, Valentina Panzeri, Pamela Bielli, Donatella Farini, Emanuela Pilozzi, Gianfranco Delle Fave, Gabriele Capurso, Claudio Sette
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extremely poor prognosis. The standard chemotherapeutic drug, gemcitabine, does not offer significant improvements for PDAC management due to the rapid acquisition of drug resistance by patients. Recent evidence indicates that epithelial-to-mesenchymal transition (EMT) of PDAC cells is strictly associated to early metastasization and resistance to chemotherapy. However, it is not exactly clear how EMT is related to drug resistance or how chemotherapy influences EMT...
November 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29078789/mir-92b-3p-acts-as-a-tumor-suppressor-by-targeting-gabra3-in-pancreatic-cancer
#6
Manmei Long, Ming Zhan, Sunwang Xu, Ruimeng Yang, Wei Chen, Shilei Zhang, Yongheng Shi, Qiao He, Man Mohan, Qiang Liu, Jian Wang
BACKGROUND: MicroRNAs (miRNAs) can act as oncogenes or tumor suppressors by controlling cell proliferation, differentiation, metastasis and apoptosis, and miRNA dysregulation is involved in the development of pancreatic cancer (PC). Our previous study demonstrated that Gabra3 plays critical roles in cancer progression. However, whether Gabra3 is regulated by miRNAs in PC remains unknown. METHODS: The expression levels of miR-92b-3p and Gabra3 were measured by quantitative PCR (qPCR), immunoblotting, in situ hybridization (ISH) and immunohistochemistry (IHC)...
October 27, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/29050264/the-microrna-expression-signature-of-pancreatic-ductal-adenocarcinoma-by-rna-sequencing-anti-tumour-functions-of-the-microrna-216-cluster
#7
Keiichi Yonemori, Naohiko Seki, Tetsuya Idichi, Hiroshi Kurahara, Yusaku Osako, Keiichi Koshizuka, Takayuki Arai, Atsushi Okato, Yoshiaki Kita, Takaaki Arigami, Yuko Mataki, Yuko Kijima, Kosei Maemura, Shoji Natsugoe
We analysed the RNA sequence-based microRNA (miRNA) signature of pancreatic ductal adenocarcinoma (PDAC). Aberrantly expressed miRNAs were successfully identified in this signature. Using the PDAC signature, we focused on 4 clustered miRNAs, miR-216a-5p, miR-216a-3p, miR-216b-5p and miR-216b-3p on human chromosome 2p16.1. All members of the miR-216 cluster were significantly reduced in PDAC specimens. Ectopic expression of these miRNAs suppressed cancer cell aggressiveness, suggesting miR-216 cluster as anti-tumour miRNAs in PDAC cells...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29048402/mir-3656-expression-enhances-the-chemosensitivity-of-pancreatic-cancer-to-gemcitabine-through-modulation-of-the-rhof-emt-axis
#8
Rui-Meng Yang, Ming Zhan, Sun-Wang Xu, Man-Mei Long, Lin-Hua Yang, Wei Chen, Shuai Huang, Qiang Liu, Jun Zhou, Jun Zhu, Jian Wang
The highly refractory nature of pancreatic cancer (PC) to chemotherapeutic drugs is one of the key reasons contributing to the poor prognosis of this disease. MicroRNAs (miRNAs) are key regulators of gene expression and have been implicated in a variety of processes from cancer development through to drug resistance. Herein, through miRNA profiling of gemcitabine-resistant (GR) and parental PANC-1 cell lines, we found a consistent reduction of miR-3656 in GR PANC-1 cells. miR-3656 overexpression enhanced the antitumor effect of gemcitabine, whereas silencing of miR-3656 resulted in the opposite effect...
October 19, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29039566/microrna-217-inhibits-cell-proliferation-invasion-and-migration-by-targeting-tpd52l2-in-human-pancreatic-adenocarcinoma
#9
Qiuyang Chen, Peng Wang, Yue Fu, Xinchun Liu, Wenbin Xu, Jishu Wei, Wentao Gao, Kuirong Jiang, Junli Wu, Yi Miao
MicroRNAs (miRNAs) play important roles in the regulation of various tumor biological processes including proliferation and apoptosis. miR-217 has been implicated in many types of cancer, whereas its expression and potential biological function in human pancreatic adenocarcinoma (HPAC) remain unclear. We aimed to investigate the clinical significance of miR-217 in patients with pancreatic carcinoma and its role and underlying molecular mechanism in HPAC. We collected 15 pairs of pancreatic cancer and normal pancreas tissues to evaluate the expression of miR-217 and tumor protein D52-like 2 (Tpd52l2)...
October 16, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29028097/microrna-217-functions-as-a-prognosis-predictor-and-inhibits-pancreatic-cancer-cell-proliferation-and-invasion-via-targeting-e2f3
#10
J Yang, H-F Zhang, C-F Qin
OBJECTIVE: Pancreatic cancer (PC) is the most malignant tumor among all the tumors in the digestive system. MiR-217 has been reported to take a critical part in various malignant tumors. The aim of this study was to explore the function of MiR-217 in pancreatic cancer and its target genes. PATIENTS AND METHODS: Twenty pairs of PC tissues and matched normal adjacent pancreatic tissues were collected. The expression of miR-217 in PC tissues and normal pancreatic tissues was detected by Real-time polymerase chain reaction (PCR)...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28990111/microrna%C3%A2-720-inhibits-pancreatic-cancer-cell-proliferation-and-invasion-by-directly-targeting-cyclin-d1
#11
Yu Zhang, Yueying Su, Yabing Zhao, Guoqiang Lv, Ying Luo
Pancreatic cancer is the fourth leading cause of cancer‑associated deaths in Western countries, and ranks sixth among cancer‑associated diseases, with the highest mortality rate in China. Deregulation of micro (miR) RNA may contribute to the occurrence and progression of numerous cancers, including pancreatic cancer. In particular, deregulation of microRNA‑720 (miR‑720) has been reported in various types of human cancer. However, the expression and biological role of miR‑720 in pancreatic cancer remains to be elucidated...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28968959/mir-187-overexpression-inhibits-cervical-cancer-progression-by-targeting-hpv16-e6
#12
Mao Lin, Xiang-Yang Xue, Shu-Zhen Liang, Yin-Xiong Li, You-Yong Lv, Li-Hua He, Ke-Cheng Xu, Li-Fang Zhang, Ji-Bing Chen, Li-Zhi Niu
Aberrantly expressed microRNAs contribute to the initiation and progression of human cancer. MiRNA-187 has been reported in nasopharyngeal, renal, pancreatic, prostate, and esophageal cancer, and acts as a tumor suppressor or oncogene. However, the underlying function of miRNA-187 in cervical cancer remains largely unexplored. In the present study, we demonstrated significantly miRNA-187 down-regulation in cervical cancer tissues and cell lines compared to their normal counterparts. Kaplan-Meier analysis revealed that decreased miRNA-187 was closely associated with shorter overall survival and relapse-free survival...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28962129/microrna-186-affects-the-proliferation-of-tumor-cells-via-yes-associated-protein-1-in-the-occurrence-and-development-of-pancreatic-cancer
#13
Qinghui Niu, Xiaoyu Li, Di Xia, Yueping Jiang, Zibin Tian, Cheng Bian, Cuiping Zhang, Pei Liu, Fengjuan Zhang, Yuling Yang, Guanglan Wang
The present study aimed to determine the expression of microRNA (miRNA or miR)-186 in tumor tissues and peripheral blood of patients with pancreatic cancer (PC), as well as its mechanism of regulation. A total of 65 patients with PC who underwent surgery between June 2013 and October 2015 were included. In addition, 59 healthy subjects were recruited as controls. Reverse transcription-quantitative polymerase chain reaction was used to measure the expression of mRNA and miRNA. Western blotting and enzyme-linked immunosorbent assay were used to determine protein expression...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28947981/lin28b-facilitates-the-progression-and-metastasis-of-pancreatic-ductal-adenocarcinoma
#14
Yunchao Wang, Jian Li, Shixiang Guo, Yongsheng Ouyang, Liangyu Yin, Songsong Liu, Zhiping Zhao, Jiali Yang, Wenjie Huang, Huan Qin, Xin Zhao, Bing Ni, Huaizhi Wang
Lin28B, a Lin28 homologue, represses the biogenesis of let-7 microRNAs (miRNAs), has a role in tumorigenesis, and is considered a potential therapeutic target for various human malignancies. However, the associations between Lin28B and the clinical features and outcomes of patients with pancreatic ductal adenocarcinoma (PDAC) remain unclear. In this study, we explored the clinical significance of Lin28B in PDAC and its association with metastasis by examining tissues from patients with PDAC and elucidated the molecular mechanisms using PDAC cell lines...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28941804/mir-132-promotes-the-proliferation-invasion-and-migration-of-human-pancreatic-carcinoma-by-inhibition-of-the-tumor-suppressor-gene-pten
#15
REVIEW
Hui Zhang, Aixiang Liu, Xielin Feng, Lang Tian, Wentao Bo, Haiqing Wang, Yong Hu
MicroRNA (miRNAs) emerges as key oncogene or tumor suppressor in a variety of cancers including pancreatic carcinoma. In this study, we detected the role of miR-132 in development and progression of pancreatic cancer and the underlying mechanism. First, the expression of miR-132 in pancreatic carcinoma and adjacent non-cancerous tissues were detected by qRT-PCR. Then, the role of miR-132 in biological function of pancreatic carcinoma cells was investigated. Our results identified that miR-132 was generally upregulated in pancreatic carcinoma, and phosphatase and tensin homolog (PTEN) was generally downregulated...
September 20, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28928875/microrna-216b-5p-functions-as-a-tumor-suppressive-rna-by-targeting-tpt1-in-pancreatic-cancer-cells
#16
Yu You, Jiaxin Tan, Yi Gong, Haisu Dai, Haowei Chen, Xuejun Xu, Aigang Yang, Yujun Zhang, Ping Bie
MicroRNAs (miRNAs) are increasingly recognized as being involved in pancreatic cancer progression by directly regulating the expression of their targets. In this study, we showed that miR-216b-5p expression was significantly decreased in pancreatic cancer tissues and cell lines. In addition, low miR-216b-5p expression was significantly associated with large tumor size and advanced TNM stage. Meanwhile, both Kaplan-Meier and multivariate survival analysis showed that decreased miR-216b-5p expression was associated with overall survival...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28927071/microrna-452-suppresses-pancreatic-cancer-migration-and-invasion-by-directly-targeting-b-cell-specific-moloney-murine-leukemia-virus-insertion-site-1
#17
Hongyan Li, Yan Wu, Peixiu Li
Pancreatic cancer, one of the most common cancers globally, is the fourth most common cause of cancer-associated mortality in the USA. The 5-year relative survival rate for patients with pancreatic cancer is ~5% and the median survival time is only 6 months. The poor prognosis is mainly due to early and aggressive local invasion and metastasis, as well as dissemination of the pancreatic cancer cells. The present study demonstrated that microRNA-452 (miR-452) was markedly downregulated in pancreatic cancer tissues, particularly in metastatic tumors and pancreatic cancer cell lines...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28904340/microrna-196b-inhibits-late-apoptosis-of-pancreatic-cancer-cells-by-targeting-cadm1
#18
Hong-Ling Wang, Rui Zhou, Jing Liu, Ying Chang, Shi Liu, Xiao-Bing Wang, Mei-Fang Huang, Qiu Zhao
Pancreatic cancer (PC), as the leading cause of cancer death worldwide, is one of the deadliest tumors with a very low 5-year survival rate. Therefore, it is urgent to seek new biomarkers of PC for more accurate and reliable treatments. To identify the differentially expressed miRNAs (DEM) in PC tissues, we performed the systematic microarray and qRT-PCR analyses. We found miR-196b was the top dysregulated DEM in PC tissues as compared with the corresponding adjacent tissues, and positively correlated with poor differentiation, tumor size, lymphatic invasion and TNM stage...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887583/mir-608-regulating-the-expression-of-ribonucleotide-reductase-m1-and-cytidine-deaminase-is-repressed-through-induced-gemcitabine-chemoresistance-in-pancreatic-cancer-cells
#19
Azam Rajabpour, Ali Afgar, Habibollah Mahmoodzadeh, Jalal-E-Din Radfar, Farzad Rajaei, Ladan Teimoori-Toolabi
PURPOSE: Gemcitabine resistance is the main problem in pancreatic adenocarcinoma patients. Hence, we aimed to identify the correlation between expression of RRM1 and CDA as the resistance genes and their predicted targeting miR-608 in the resistant pancreatic cancer cell lines to gemcitabine. METHODS: Dual luciferase assay was performed to determine whether both RRM1 and CDA are targeted by miR-608 in 293T and pancreatic cancer cell lines. AsPC-1 and MIA PaCa-2 cell lines became gradually resistant to gemcitabine by exposing to the increasing doses of gemcitabine...
October 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28881803/regulation-of-actin-binding-protein-anln-by-antitumor-mir-217-inhibits-cancer-cell-aggressiveness-in-pancreatic-ductal-adenocarcinoma
#20
Tetsuya Idichi, Naohiko Seki, Hiroshi Kurahara, Keiichi Yonemori, Yusaku Osako, Takayuki Arai, Atsushi Okato, Yoshiaki Kita, Takaaki Arigami, Yuko Mataki, Yuko Kijima, Kosei Maemura, Shoji Natsugoe
Analysis of our microRNA (miRNA) expression signature of pancreatic ductal adenocarcinoma (PDAC) revealed that microRNA-217 (miR-217) was significantly reduced in cancer tissues. The aim of this study was to investigate the antitumor roles of miR-217 in PDAC cells and to identify miR-217-mediated molecular pathways involved in PDAC aggressiveness. The expression levels of miR-217 were significantly reduced in PDAC clinical specimens. Ectopic expression of miR-217 significantly suppressed cancer cell migration and invasion...
August 8, 2017: Oncotarget
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