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https://www.readbyqxmd.com/read/29777970/understanding-self-concealment-within-a-framework-of-eating-disorder-cognitions-and-body-image-flexibility-conceptual-and-applied-implications
#1
Akihiko Masuda, Janet D Latner, John P Barlie, Kayla Sargent
Although self-concealment has been long recognized in the context of body image disturbance and disordered eating concerns, empirical evidence remains limited. Following cognitive behavioral therapy (CBT) models of disordered eating and body image concerns, the present cross-sectional study examined whether the construct of self-concealment was related to disordered eating and body image concerns. More specifically, we investigated whether eating disorder cognitions and body image flexibility, two factors linked to the maintenance of disordered eating concerns, are uniquely associated with self-concealment, while controlling for key demographic and sociocultural variables...
May 16, 2018: Eating Behaviors
https://www.readbyqxmd.com/read/29777343/the-effects-of-pre-treatment-depressive-symptoms-on-quality-of-life-across-cognitive-behavioral-therapy-for-chronic-pain
#2
Justin M Hughes, Eric A Seemann, J Michael George, K Dean Willis
Recent studies suggest that chronic pain affects millions and carries significant physical, financial, and social burdens, and thus adversely affects quality of life (QOL). Cognitive behavioral therapy for chronic pain (CBTp) is a non-pharmacological treatment method which has been shown to reduce a sufferer's experience of chronic pain and improve overall QOL. These and other studies also indicate that affective symptoms likely impact the effectiveness of CBTp. The current study focused on the effects of depressive symptoms on changes in QOL ratings across a 12-session CBT for chronic pain...
May 17, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29776708/predictors-of-treatment-outcome-for-the-unified-protocol-for-transdiagnostic-treatment-of-emotional-disorders-in-children-up-c
#3
Sarah M Kennedy, Niza A Tonarely, Jamie A Sherman, Jill Ehrenreich-May
Various efficacious treatment packages exist for youth anxiety, and cognitive behavior therapy (CBT) is now considered to be a well-established treatment for child anxiety disorders (Higa-McMillan, Francis, Rith-Najarian, & Chorpita, 2016). Improving outcomes for the significant proportion of anxious youth who demonstrate inadequate response to CBT is imperative, but our understanding of who does and does not benefit is incomplete. Further, there are no known empirical studies of predictors of treatment response for youth who receive a transdiagnostic intervention for anxiety or depression, and it is therefore unclear whether predictors of response to a transdiagnostic treatment for children are similar to those found in previous studies of anxiety-specific treatments...
May 15, 2018: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29776349/randomised-controlled-trial-rct-of-cannabinoid-replacement-therapy-nabiximols-for-the-management-of-treatment-resistant-cannabis-dependent-patients-a-study-protocol
#4
Anjali K Bhardwaj, David J Allsop, Jan Copeland, Iain S McGregor, Adrian Dunlop, Marian Shanahan, Raimondo Bruno, Nghi Phung, Mark Montebello, Craig Sadler, Jessica Gugusheff, Melissa Jackson, Jennifer Luksza, Nicholas Lintzeris
BACKGROUND: The cannabis extract nabiximols (Sativex®) effectively supresses withdrawal symptoms and cravings in treatment resistant cannabis dependent individuals, who have high relapse rates following conventional withdrawal treatments. This study examines the efficacy, safety and cost-effectiveness of longer-term nabiximols treatment for outpatient cannabis dependent patients who have not responded to previous conventional treatment approaches. METHODS/DESIGN: A phase III multi-site outpatient, randomised, double-blinded, placebo controlled parallel design, comparing a 12-week course of nabiximols to placebo, with follow up at 24 weeks after enrolment...
May 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29771217/cognitive-behavioral-therapy-mindfulness-and-hypnosis-as-treatment-methods-for-generalized-anxiety-disorder
#5
Carolyn Daitch
Individuals suffering from generalized anxiety disorder (GAD) experience a broad range of physical, emotional, and cognitive distress. A hallmark of GAD is anxiety around making decisions. Many clinicians notice improvements in patients through specific modalities, such as mindfulness, hypnosis, and cognitive behavioral therapy (CBT); however, these individual methods sometimes fall short. Clinicians and researchers alike note that it can be more effective to combine these three methods into an integrative treatment protocol...
July 2018: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/29771122/computation-guided-rational-design-of-a-peptide-motif-that-reacts-with-cyanobenzothiazoles-via-internal-cysteine-lysine-relay
#6
Samantha G L Keyser, Ashley Utz, Carolyn R Bertozzi
Site-selective protein modification based on covalent reactions of peptide tags and small molecules is a key capability for basic research as well as for the development of new therapeutic bioconjugates. Here we describe the computation-guided rational design of a cysteine- and lysine-containing 11-residue peptide sequence that reacts with 2-cyanobenzothiazole (CBT) derivatives. Our data show that the cysteine residue reversibly reacts with the nitrile group on the CBT moiety to form an intermediate thioimidate, which undergoes irreversible SN transfer to the lysine residue, yielding an amidine-linked product...
May 17, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29771094/-the-surgical-treatment-of-carotid-body-tumor-and-prevention-and-treatment-of-complications
#7
REVIEW
T Chen, Y Shen, J Zhu
Carotid body tumor is an uncommon paraganglioma tumor in the head and neck region. Carotid angiography remains the gold standard for this tumor.Surgical treatment has been universally accepted as the main treatment of CBT, resection of it is technically challenging because of the location. In order to reduce the morbidity of intraoperative and postoperative complications,we summarize the surgical treatment and the prevention and treatment of complication of this neoplasm, after retrieving the domestic and foreign literature...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29769157/the-role-of-performance-quality-in-adolescents-self-evaluation-and-rumination-after-a-speech-is-it-contingent-on-social-anxiety-level
#8
Anke W Blöte, Anne C Miers, Esther Van den Bos, P Michiel Westenberg
BACKGROUND: Cognitive behavioural therapy (CBT) has relatively poor outcomes for youth with social anxiety, possibly because broad-based CBT is not tailored to their specific needs. Treatment of social anxiety in youth may need to pay more attention to negative social cognitions that are considered a key factor in social anxiety development and maintenance. AIMS: The aim of the present study was to learn more about the role of performance quality in adolescents' cognitions about their social performance and, in particular, the moderating role social anxiety plays in the relationship between performance quality and self-cognitions...
May 17, 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29769096/a-methodology-for-generating-a-tailored-implementation-blueprint-an-exemplar-from-a-youth-residential-setting
#9
Cara C Lewis, Kelli Scott, Brigid R Marriott
BACKGROUND: Tailored implementation approaches are touted as more likely to support the integration of evidence-based practices. However, to our knowledge, few methodologies for tailoring implementations exist. This manuscript will apply a model-driven, mixed methods approach to a needs assessment to identify the determinants of practice, and pilot a modified conjoint analysis method to generate an implementation blueprint using a case example of a cognitive behavioral therapy (CBT) implementation in a youth residential center...
May 16, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29768125/investigating-the-usefulness-of-trauma-focused-cognitive-behavioral-therapy-in-adolescent-residential-care
#10
Valerie C Joiner, Frederick P Buttell
OBJECTIVE: This study investigated the usefulness of the trauma intervention, trauma-focused cognitive behavioral therapy (TF-CBT), for adolescents in residential treatment. METHOD: The study employed a secondary analysis of 132 adolescent trauma cases collected from youth while in a residential treatment facility in Mississippi. RESULTS: Analysis indicated that clients showed significant decreases in posttraumatic stress disorder (PTSD) severity scores after receiving TF-CBT in residential care...
May 16, 2018: Journal of Evidence-informed Social Work
https://www.readbyqxmd.com/read/29763767/to-deliver-or-not-to-deliver-cognitive-behavioral-therapy-for-eating-disorders-replication-and-extension-of-our-understanding-of-why-therapists-fail-to-do-what-they-should-do
#11
Sandra Mulkens, Chloé de Vos, Anastacia de Graaff, Glenn Waller
OBJECTIVE: This study investigated the extent to which therapists fail to apply empirically supported treatments in a sample of clinicians in The Netherlands, delivering cognitive behavioral therapy for eating disorders (CBT-ED). It aimed to replicate previous findings, and to extend them by examining other potential intra-individual factors associated with the level of (non-)use of core CBT-ED techniques. METHOD: Participants were 139 clinicians (127 women; mean age 41...
May 4, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29762213/feasibility-of-a-cognitive-behavioral-and-environmental-intervention-for-sleep-wake-difficulties-in-community-dwelling-cancer-patients-receiving-palliative-care
#12
Marie Solange Bernatchez, Josée Savard, Marie-Hélène Savard, Michèle Aubin
BACKGROUND: High rates of sleep-wake difficulties have been found in patients with cancer receiving palliative care. Pharmacotherapy is the most frequently used treatment option to manage these difficulties despite numerous adverse effects and the absence of empirical evidence of its efficacy and innocuity in palliative care. OBJECTIVE: This pilot study aimed to assess the feasibility and acceptability of a cognitive-behavioral and environmental intervention (CBT-E) to improve insomnia and hypersomnolence in patients with a poor functioning level and to collect preliminary data on its effects...
May 14, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29761488/psychological-therapies-for-treatment-resistant-depression-in-adults
#13
REVIEW
Sharea Ijaz, Philippa Davies, Catherine J Williams, David Kessler, Glyn Lewis, Nicola Wiles
BACKGROUND: Antidepressants are a first-line treatment for adults with moderate to severe major depression. However, many people prescribed antidepressants for depression don't respond fully to such medication, and little evidence is available to inform the most appropriate 'next step' treatment for such patients, who may be referred to as having treatment-resistant depression (TRD). National Institute for Health and Care Excellence (NICE) guidance suggests that the 'next step' for those who do not respond to antidepressants may include a change in the dose or type of antidepressant medication, the addition of another medication, or the start of psychotherapy...
May 14, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29761016/the-effects-of-cognitive-behavioral-therapy-on-resting-state-functional-brain-network-in-drug-naive-patients-with-obsessive-compulsive-disorder
#14
Ping Li, Xiangyun Yang, Andrew J Greenshaw, Sufang Li, Jia Luo, Haiying Han, Jing Liu, Zhaoxi Zhong, Zhihua Guo, Hongfang Xiong, Shumin Yao, Yunhui Chen, Jing Sun, Zhanjiang Li
Objectives: Although cognitive behavioral therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD), the treatment mechanisms remain poorly understood. This study aimed to investigate the effects of CBT on changes in the intrinsic whole-brain functional network of OCD patients. Materials and Methods: Twenty drug-naive and noncomorbid OCD patients were recruited, and resting-state functional magnetic resonance imaging was performed before and after 12 weeks of CBT...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29760162/unrelated-cord-blood-transplantation-in-patients-with-acquired-refractory-aplastic-anemia-a-nationwide-phase-ii-study
#15
Regis Peffault de Latour, Sylvie Chevret, Charlotte Jubert, Anne Sirvent, Claire Galambrun, Annalisa Ruggeri, Virginie Gandemer, Jérôme Cornillon, Fanny Rialland, Jean-Hugues H Dalle, Edouard Forcade, Benedicte Bruno, Catherine Paillard, Pierre S Rorlich, Alexandra Salmon, Sabine Fürst, Flore Sicre de Fontbrune, Marie Therese Rubio, Jacques-Olivier Bay, Mohamad Mohty, Jerome Larghero, Eliane Gluckman, Gerard Socié
Outcomes remain poor for patients with refractory severe aplastic anemia (SAA). Alternative donor transplantation may be considered, but results from previous studies have not been encouraging. We conducted a prospective nationwide phase II study to assess the efficacy and safety of unrelated cord blood transplantation (CBT) in patients with refractory SAA (APCORD protocol, NCT 01343953). To demonstrate a significant difference in one-year survival from 20% (null hypothesis) to 50% (alternative hypothesis), we needed to include 25 transplanted patients...
May 14, 2018: Blood
https://www.readbyqxmd.com/read/29756385/absence-of-early-hhv-6-reactivation-after-cord-blood-allograft-predicts-powerful-graft-versus-tumor-effect
#16
Armin Rashidi, Maryam Ebadi, Bassil Said, Qing Cao, Ryan Shanley, Julie Curtsinger, Nelli Bejanyan, Erica D Warlick, Jaime S Green, Claudio G Brunstein, Jeffrey S Miller, Daniel J Weisdorf
Approximately 75% of cord blood transplant (CBT) recipients experience human herpes virus-6 (HHV-6) reactivation. Considering the immunomodulatory effects of HHV-6, we hypothesized that early HHV-6 reactivation may influence the risk of relapse of the underlying hematologic malignancy. In 152 CBT recipients with hematological malignancies, we determined the association between HHV-6 reactivation by day +28 and 2-year cumulative incidence of relapse. In univariate analysis, the absence of HHV-6 reactivation (n = 32) was associated with less relapse (26 [18-35]% vs...
May 14, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29754102/early-psychological-interventions-for-posttraumatic-stress-depression-and-anxiety-after-traumatic-injury-a-systematic-review-and-meta-analysis
#17
REVIEW
Melita J Giummarra, Alyse Lennox, Gezelle Dali, Beth Costa, Belinda J Gabbe
The psychological impacts of injury have significant long-term implications on injury recovery. This review examined the effectiveness of interventions delivered within three months of injury on reducing the severity of posttraumatic stress disorder (PTSD), anxiety and depression symptoms. A systematic search of seven databases (PsycINFO, Medline, Web of Science, CINAHL, Embase, Scopus and Cochrane Library) identified 15,224 records. 212 full-text articles were retrieved, 26 studies were included in narrative synthesis, and 12 studies with lower risk of bias were included in meta-analyses...
May 5, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29753926/long-term-clinical-effect-of-group-cognitive-behavioral-therapy-for-insomnia-a-case-series-study
#18
Vincenza Castronovo, Andrea Galbiati, Marco Sforza, Mattia Poletti, Laura Giarolli, Tracy Kuo, Marco Zucconi, Mauro Manconi, Michael Hensley, Charles Morin, Luigi Ferini-Strambi
OBJECTIVE: Cognitive-behavioral therapy for insomnia (CBT-I) is recognized as the first-choice intervention for insomnia. One of the best-known advantages of CBT-I in comparison with pharmacotherapy is its long-term effect. However, only few studies have assessed its benefits with follow-up periods of longer than three years. In this clinical case series study we aimed to describe the long-term effects of group CBT-I after a mean 7.8 ± 1.6 years of follow-up (range 4-10 years). METHODS: A total of 292 insomnia disorder (ID) patients were consecutively enrolled at the Sleep Disorders Center of San Raffaele Hospital, Milan; 123 patients (82 (66...
April 11, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29753839/platelet-transfusion-refractoriness-in-single-unit-cord-blood-transplantation-for-adults-risk-factors-and-clinical-outcomes
#19
Susumu Tanoue, Takaaki Konuma, Seiko Kato, Maki Oiwa-Monna, Masamichi Isobe, Koji Jimbo, Satoshi Takahashi, Arinobu Tojo
Platelet transfusion refractoriness (PTR) is frequently observed after allogeneic hematopoietic cell transplantation (HCT). However, the incidence of and risk factors for PTR, and impact of PTR on transplant outcomes after cord blood transplantation (CBT) have not been fully investigated. We retrospectively analyzed 185 adult patients who received single-unit CBT in our institute. The mean 16-hour corrected count increment (CCI) for the 5,840 platelet transfusions was 3.68×109 /l. Among them, 3,196 transfusions (54...
May 10, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29753836/a-modified-intensive-strategy-to-prevent-cmv-disease-in-seropositive-umbilical-cord-blood-transplant-recipients
#20
Joshua A Hill, Steven A Pergam, Emily Cox, Hu Xie, Wendy M Leisenring, Michael Boeckh, Colleen Delaney, Filippo Milano
We previously demonstrated a lower rate of CMV reactivation and disease among seropositive umbilical cord blood transplant (CBT) recipients receiving an intensive prophylaxis strategy consisting of ganciclovir on days -8 to -2 pre-transplant, high-dose valacyclovir post-transplant, and twice-weekly serum CMV PCR testing. We hypothesized that a modified intensive strategy excluding pre-transplant ganciclovir would be similarly effective. We compared the risk of CMV reactivation, occurrence of CMV disease, and duration of anti-CMV therapy by day 100 post-CBT in patients receiving the modified intensive and intensive strategies...
May 10, 2018: Biology of Blood and Marrow Transplantation
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