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https://www.readbyqxmd.com/read/28445851/development-and-validation-of-a-uhplc-esi-ms-ms-method-for-the-simultaneous-quantification-of-mammal-lysophosphatidylcholines-and-lysophosphatidylethanolamines-in-serum
#1
Susana Suárez-García, Lluís Arola, Aïda Pascual-Serrano, Anna Arola-Arnal, Gerard Aragonès, Cinta Bladé, Manuel Suárez
Recent investigations based on non-targeted metabolomics have proposed lysophospholipids (Lyso-PLs) as biomarkers of different diseases. In particular, lysophosphatidylcholines (Lyso-PCs) and lysophosphatidylethanolamines (Lyso-PEs) have been associated with serious lipid pathologies. Methods to determine the different molecular species in a biological sample and to quantify even less abundant species are required for the evaluation of the Lyso-PL pattern as a novel comprehensive biomarker of dyslipidemia. This study describes the development and validation of an ultra-high-performance liquid chromatography coupled to tandem mass spectrometry assay for the determination of a large number of Lyso-PCs and Lyso-PEs in biological samples...
April 18, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28444229/a-novel-but-frequent-variant-in-lpa-kiv-2-is-associated-with-a-pronounced-lp-a-and-cardiovascular-risk-reduction
#2
Stefan Coassin, Gertraud Erhart, Hansi Weissensteiner, Mariana Eca Guimarães de Araújo, Claudia Lamina, Sebastian Schönherr, Lukas Forer, Margot Haun, Jamie Lee Losso, Anna Köttgen, Konrad Schmidt, Gerd Utermann, Annette Peters, Christian Gieger, Konstantin Strauch, Armin Finkenstedt, Reto Bale, Heinz Zoller, Bernhard Paulweber, Kai-Uwe Eckardt, Alexander Hüttenhofer, Lukas A Huber, Florian Kronenberg
Aims: Lp(a) concentrations represent a major cardiovascular risk factor and are almost entirely controlled by one single locus (LPA). However, many genetic factors in LPA governing the enormous variance of Lp(a) levels are still unknown. Since up to 70% of the LPA coding sequence are located in a difficult to access hypervariable copy number variation named KIV-2, we hypothesized that it may contain novel functional variants with pronounced effects on Lp(a) concentrations. We performed a large scale mutation analysis in the KIV-2 using an extreme phenotype approach...
April 25, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28436017/attachment-styles-and-clinical-correlates-in-people-at-ultra-high-risk-for-psychosis
#3
Debra A Russo, Jan Stochl, Joanne Hodgekins, Maria Iglesias-González, Penelope Chipps, Michelle Painter, Peter B Jones, Jesus Perez
Evidence suggests that attachment styles may influence subclinical psychosis phenotypes (schizotypy) and affective disorders and may play a part in the association between psychosis and childhood adversity. However, the role of attachment in the initial stages of psychosis remains poorly understood. Our main aim was to describe and compare attachment styles in 60 individuals at ultra high risk for psychosis (UHR) and a matched sample of 60 healthy volunteers (HV). The HV had lower anxious and avoidant attachment scores than the UHR individuals (p < ...
April 24, 2017: British Journal of Psychology
https://www.readbyqxmd.com/read/28430148/a-rapid-magnetic-solid-phase-extraction-method-followed-by-liquid-chromatography-tandem-mass-spectrometry-analysis-for-the-determination-of-mycotoxins-in-cereals
#4
Giorgia La Barbera, Anna Laura Capriotti, Chiara Cavaliere, Patrizia Foglia, Carmela Maria Montone, Riccardo Zenezini Chiozzi, Aldo Laganà
Mycotoxins can contaminate various food commodities, including cereals. Moreover, mycotoxins of different classes can co-contaminate food, increasing human health risk. Several analytical methods have been published in the literature dealing with mycotoxins determination in cereals. Nevertheless, in the present work, the aim was to propose an easy and effective system for the extraction of six of the main mycotoxins from corn meal and durum wheat flour, i.e., the main four aflatoxins, ochratoxin A, and the mycoestrogen zearalenone...
April 21, 2017: Toxins
https://www.readbyqxmd.com/read/28422422/psychopathology-and-social-functioning-of-42-subjects-from-a-danish-ultra-high-risk-cohort
#5
Helle Karkov Madsen, Dorte Nordholm, Kristine Krakauer, Lasse Randers, Merete Nordentoft
AIM: To make a thorough characterization of the co-morbidity, psychopathology and demographics in the first Danish ultra high-risk (UHR) sample. METHOD: Forty-two UHR subjects went through comprehensive interviews assessing their psychopathology, psychiatric disorders, substance use and family history of psychiatric disorders. RESULTS: All UHR subjects met the criteria of at least 1 axis I diagnosis in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) and met on average four diagnoses (both axis I and II), mostly within the areas of depression, anxiety and substance abuse...
April 19, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28420318/advancing-clinicopathologic-diagnosis-of-high-risk-neuroblastoma-using-computerized-image-analysis-and-proteomic-profiling
#6
M Khalid Khan Niazi, Jonathan H Chung, Katherine J Heaton-Johnson, Daniel Martinez, Raquel Castellanos, Meredith S Irwin, Stephen R Master, Bruce R Pawel, Metin N Gurcan, Daniel A Weiser
A subset of patients with neuroblastoma are at extremely high risk for treatment failure, though they are not identifiable at diagnosis and therefore have the highest mortality with conventional treatment approaches. Despite tremendous understanding of clinical and biological features that correlate with prognosis, neuroblastoma at ultra-high risk for treatment failure remains a diagnostic challenge. As a first step towards improving prognostic risk stratification within the high-risk group of patients, we determined the feasibility of using computerized image analysis and proteomic profiling on single slides from diagnostic tissue specimens...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28417199/intake-of-7-8-dihydroxyflavone-from-pregnancy-to-weaning-prevents-cognitive-deficits-in-adult-offspring-after-maternal-immune-activation
#7
Mei Han, Ji-Chun Zhang, Xu-Feng Huang, Kenji Hashimoto
Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role in the brain neurodevelopment. The exposure of pregnant mice to polyinosinic-polycytidylic acid [poly(I:C)] causes cognitive deficits in adult offspring. Supplementation with a TrkB agonist, 7,8-dihydroxyflavone, in poly(I:C)-treated pregnant mice from pregnancy to weaning could prevent the onset of cognitive deficits and reduced BDNF-TrkB signaling in the prefrontal cortex of their adult offspring...
April 17, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28415873/structural-brain-changes-in-schizophrenia-at-different-stages-of-the-illness-a-selective-review-of-longitudinal-magnetic-resonance-imaging-studies
#8
Bruno Dietsche, Tilo Kircher, Irina Falkenberg
OBJECTIVE: Schizophrenia is a devastating mental disorder accompanied by aberrant structural brain connectivity. The question whether schizophrenia is a progressive brain disorder is yet to be resolved. Thus, it is not clear when these structural alterations occur and how they develop over time. METHODS: In our selective review, we summarized recent findings from longitudinal magnetic resonance imaging studies investigating structural brain alterations and its impact on clinical outcome at different stages of the illness: (1) subjects at ultra-high risk of developing psychosis, (2) patients with a first episode psychosis, and (3) chronically ill patients...
May 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28412612/impairment-in-social-functioning-differentiates-youth-meeting-ultra-high-risk-for-psychosis-criteria-from-other-mental-health-help-seekers-a-validation-of-the-italian-version-of-the-global-functioning-social-and-global-functioning-role-scales
#9
Nella Lo Cascio, Martina Curto, Patrizio Pasqualetti, Juliana Fortes Lindau, Nicoletta Girardi, Riccardo Saba, Martina Brandizzi, Elena Monducci, Alice Masillo, Giada Colafrancesco, Andrea Solfanelli, Franco De Crescenzo, Georgios D Kotzalidis, Claudia Dario, Mauro Ferrara, Stefano Vicari, Paolo Girardi, Andrea M Auther, Barbara A Cornblatt, Christoph U Correll, Paolo Fiori Nastro
Social and occupational impairments are present in the schizophrenia prodrome, and poor social functioning predicts transition to psychosis in Ultra-High Risk (UHR) individuals. We aimed to: 1) validate the Italian version of the Global Functioning: Social (GF: S) and Global Functioning: Role (GF: S) scales; 2) evaluate their association with UHR criteria. Participants were 12-21-years-old (age, mean=15.2, standard deviation=2.1, male/female ratio=117/120) nonpsychotic help-seekers, meeting (N=39) or not (N=198) UHR criteria...
April 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28406913/no-age-effect-in-the-prevalence-and-clinical-significance-of-ultra-high-risk-symptoms-and-criteria-for-psychosis-in-22q11-deletion-syndrome-confirmation-of-the-genetically-driven-risk-for-psychosis
#10
MULTICENTER STUDY
Marco Armando, Maude Schneider, Maria Pontillo, Stefano Vicari, Martin Debbané, Frauke Schultze-Lutter, Stephan Eliez
BACKGROUND: The 22q11.2 deletion syndrome (22q11DS) is one of the highest known risk factors for schizophrenia. Thus, the detection of 22q11DS patients at particularly high risk of psychosis is important, yet studies on the clinical significance of the widely used ultra-high risk (UHR) criteria in 22q11DS are inconclusive. Since age was reported to moderate clinical significance of UHR symptoms in community samples, we explored whether age at presentation of UHR symptoms and criteria may explain part of this heterogeneity...
2017: PloS One
https://www.readbyqxmd.com/read/28393238/modulation-of-interactions-of-neuroblastoma-cell-lines-with-extracellular-matrix-proteins-affects-their-sensitivity-to-treatment-with-the-anti-gd2-ganglioside-antibody-14g2a
#11
Irena Horwacik, Hanna Rokita
Children diagnosed with high risk neuroblastoma have poor prognosis which stimulates efforts to broaden therapies of the neoplasm. GD2-ganglioside (GD2) marks neuroblastoma cells and is a target for monoclonal antibodies. We have recently shown that some neuroblastoma cell lines are sensitive to direct cytotoxicity of the anti-GD2 mouse monoclonal antibody 14G2a (mAb). For IMR-32 and LA-N-1 cell lines, treatment with the 14G2a mAb induced evident changes in appearance such as cell rounding, aggregation, loose contact with culture plastic, or detachment...
April 7, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28392234/selection-of-the-highly-replicative-and-partially-multidrug-resistant-rts78t-polymerase-mutation-in-two-patients-with-chronic-hepatitis-b-virus-infection-during-tenofovir-entecavir-combination-therapy
#12
Elham Shirvani-Dastgerdi, Benjamin Y Winer, Antoni Celia-Terrassa, Yibin Kang, David Tabernero, Eray Yagmur, Francisco Rodríguez-Frías, Josep Gregori, Tom Luedde, Christian Trautwein, Alexander Ploss, Frank Tacke
Patients chronically infected with the hepatitis B virus (HBV) that are on long-term treatment with nucleoside or nucleotide analogues are at risk of selecting HBV strains with complex mutational patterns. We herein report two cases of HBV-infected patients with insufficient viral suppression despite dual antiviral therapy with entecavir (ETV) and tenofovir (TDF), of which one patient died from aggressive hepatocellular carcinoma (HCC). Ultra-deep pyrosequencing analyses revealed the selection of the rtS78T polymerase mutation in both cases that creates a premature stop codon at sC69 and thereby deletes almost the entire small HBV surface protein...
April 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28389631/metabolic-profiling-and-novel-plasma-biomarkers-for-predicting-survival-in-epithelial-ovarian-cancer
#13
Hongyu Xie, Yan Hou, Jinlong Cheng, Margarita S Openkova, Bairong Xia, Wenjie Wang, Ang Li, Kai Yang, Junnan Li, Huan Xu, Chunyan Yang, Libing Ma, Zhenzi Li, Xin Fan, Kang Li, Ge Lou
Epithelial ovarian cancer (EOC) is one of the most lethal gynecological malignancies around the world, and patients with ovarian cancer always have an extremely poor chance of survival. Therefore, it is meaningful to develop a highly efficient model that can predict the overall survival for EOC. In order to investigate whether metabolites could be used to predict the survival of EOC, we performed a metabolic analysis of 98 plasma samples with follow-up information, based on the ultra-performance liquid chromatography mass spectrometry (UPLC/MS) systems in both positive (ESI+) and negative (ESI-) modes...
March 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28389431/cognitive-behavioural-therapy-can-prevent-transition-to-psychosis-in-ultra-high-risk-participants-in-the-long-term
#14
Jean-Philippe Miron, Amal Abdel-Baki
No abstract text is available yet for this article.
April 7, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/28388546/dose-dependent-effects-of-cadmium-on-tumor-angiogenesis
#15
REVIEW
Tianshu Wei, Jin Jia, Youichiro Wada, Carolyn M Kapron, Ju Liu
Angiogenesis is crucial for tumor growth and metastasis. Cadmium (Cd) exposure is associated with elevated cancer risk and mortality. Such association is, at least in part, attributable to Cd-induced tumor angiogenesis. Nevertheless, the reported effects of Cd on tumor angiogenesis appear to be either stimulatory or inhibitory, depending on the concentrations. Ultra-low concentrations of Cd (<0.5 μM) inhibit endothelial nitric oxide synthase activation, leading to reduced endothelial nitric oxide production and attenuated tumor angiogenesis...
March 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28388455/poverty-low-education-and-the-expression-of-psychotic-like-experiences-in-the-general-population-of-s%C3%A3-o-paulo-brazil
#16
Alexandre Andrade Loch, Camille Chianca, Tania Maria Alves, Elder Lanzani Freitas, Lucas Hortêncio, Julio Cesar Andrade, Martinus Theodorus van de Bilt, Marcos Roberto Fontoni, Mauricio H Serpa, Wagner Farid Gattaz, Wulf Rössler
The aim of our study was to assess psychotic-like experiences in the general population aged 18-30 years old of the city of São Paulo, Brazil. A household survey was conducted with 1950 young-adults randomly drawn from the city's general population. The validated 92-item Portuguese version of the Prodromal Questionnaire (PQ) was used for face-to-face interviews. Latent class analysis was conducted. Mean age was of 24 years; 51.1% of the sample was of women. Mean total score on the PQ was 22.06 (SD=17.16). Considering a suggested cut-off of 14 in the positive subscale, 30...
March 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28383892/enantioseparation-of-imazalil-and-monitoring-of-its-enantioselective-degradation-in-apples-and-soils-using-ultrahigh-performance-liquid-chromatography-tandem-mass-spectrometry
#17
Runan Li, Fengshou Dong, Jun Xu, Xingang Liu, Xiaohu Wu, Xinglu Pan, Yan Tao, Zenglong Chen, Yongquan Zheng
Imazalil is a widely used systemic chiral fungicide that is still being employed as a racemic mixture without distinguishing the difference between enantiomers, which often leads to its inaccurate risk assessment. In this study, a robust and highly sensitive chiral separation method was developed for imazalil enantiomers by ultrahigh-performance liquid chromatography-tandem mass spectrometry and was further applied to study the degradation dynamics of imazalil enantiomers in apples and field soils at three sites in China...
April 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28382967/thrombotic-thrombocytopenic-purpura
#18
REVIEW
Johanna A Kremer Hovinga, Paul Coppo, Bernhard Lämmle, Joel L Moake, Toshiyuki Miyata, Karen Vanhoorelbeke
Thrombotic thrombocytopenic purpura (TTP; also known as Moschcowitz disease) is characterized by the concomitant occurrence of often severe thrombocytopenia, microangiopathic haemolytic anaemia and a variable degree of ischaemic organ damage, particularly affecting the brain, heart and kidneys. Acute TTP was almost universally fatal until the introduction of plasma therapy, which improved survival from <10% to 80-90%. However, patients who survive an acute episode are at high risk of relapse and of long-term morbidity...
April 6, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28373404/precancer-atlas-to-drive-precision-prevention-trials
#19
Avrum Spira, Matthew B Yurgelun, Ludmil Alexandrov, Anjana Rao, Rafael Bejar, Kornelia Polyak, Marios Giannakis, Ali Shilatifard, Olivera J Finn, Madhav Dhodapkar, Neil E Kay, Esteban Braggio, Eduardo Vilar, Sarah A Mazzilli, Timothy R Rebbeck, Judy E Garber, Victor E Velculescu, Mary L Disis, Douglas C Wallace, Scott M Lippman
Cancer development is a complex process driven by inherited and acquired molecular and cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality will take a fundamental rethinking and deep understanding of premalignant biology. In this Perspective, we propose a national concerted effort to create a Precancer Atlas (PCA), integrating multi-omics and immunity - basic tenets of the neoplastic process. The biology of neoplasia caused by germline mutations has led to paradigm-changing precision prevention efforts, including: tumor testing for mismatch repair (MMR) deficiency in Lynch syndrome establishing a new paradigm, combinatorial chemoprevention efficacy in familial adenomatous polyposis (FAP), signal of benefit from imaging-based early detection research in high-germline risk for pancreatic neoplasia, elucidating early ontogeny in BRCA1-mutation carriers leading to an international breast cancer prevention trial, and insights into the intricate germline-somatic-immunity interaction landscape...
April 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28360881/hemostasis-in-intracranial-hemorrhage
#20
REVIEW
Deepak Gulati, Dharti Dua, Michel T Torbey
Spontaneous non-traumatic intracerebral hemorrhage (ICH) is associated with high morbidity and mortality throughout the world with no proven effective treatment. Majority of hematoma expansion occur within 4 h after symptom onset and is associated with early deterioration and poor clinical outcome. There is a vital role of ultra-early hemostatic therapy in ICH to limit hematoma expansion. Patients at risk for hematoma expansion are with underlying hemostatic abnormalities. Treatment strategy should include appropriate intervention based on the history of use of antithrombotic use or an underlying coagulopathy in patients with ICH...
2017: Frontiers in Neurology
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