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https://www.readbyqxmd.com/read/29236922/effects-of-n-acetylcysteine-on-amphetamine-induced-sensitization-in-mice
#1
Ana P Herrmann, Roberta Andrejew, Radharani Benvenutti, Clarissa S Gama, Elaine Elisabetsky
OBJECTIVE: N-acetylcysteine (NAC) is beneficial in psychiatric conditions, including schizophrenia. Patients with schizophrenia exhibit mesolimbic dopamine hyperfunction consequent to an endogenous sensitization process. This sensitization can be modeled in rodents by repeated exposure to psychostimulants, provoking an enduring amplified response at subsequent exposure. The aim of this study was to investigate the effects of NAC on amphetamine sensitization in mice. METHODS: D-amphetamine was administered to C57BL/6 mice three times a week for 3 weeks; the dose was increased weekly from 1 to 3 mg/kg...
December 11, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29229179/clinical-role-of-breast-mri-now-and-going-forward
#2
REVIEW
D Leithner, G J Wengert, T H Helbich, S Thakur, R E Ochoa-Albiztegui, E A Morris, K Pinker
Magnetic resonance imaging (MRI) is a well-established method in breast imaging, with manifold clinical applications, including the non-invasive differentiation between benign and malignant breast lesions, preoperative staging, detection of scar versus recurrence, implant assessment, and the evaluation of high-risk patients. At present, dynamic contrast-enhanced MRI is the most sensitive imaging technique for breast cancer diagnosis, and provides excellent morphological and to some extent also functional information...
December 8, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29226868/predictors-of-age-of-diagnosis-and-survival-of-alzheimer-s-disease-in-down-syndrome
#3
Amanda Sinai, Claire Mokrysz, Jane Bernal, Ingrid Bohnen, Simon Bonell, Ken Courtenay, Karen Dodd, Dina Gazizova, Angela Hassiotis, Richard Hillier, Judith McBrien, Jane McCarthy, Kamalika Mukherji, Asim Naeem, Natalia Perez-Achiaga, Khadija Rantell, Vijaya Sharma, David Thomas, Zuzana Walker, Sarah Whitham, Andre Strydom
BACKGROUND: People with Down syndrome (DS) are an ultra-high risk population for Alzheimer's disease (AD). Understanding the factors associated with age of onset and survival in this population could highlight factors associated with modulation of the amyloid cascade. OBJECTIVE: This study aimed to establish the typical age at diagnosis and survival associated with AD in DS and the risk factors associated with these. METHODS: Data was obtained from the Aging with Down Syndrome and Intellectual Disabilities (ADSID) research database, consisting of data extracted from clinical records of patients seen by Community Intellectual Disability Services (CIDS) in England...
December 6, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29222033/multiple-perspectives-of-qingkailing-injection-fraction-single-compound-in-revealing-the-hepatotoxicity-of-baicalin-and-hyodeoxycholic-acid
#4
Jiayu Zhang, Shifeng Wang, Lulu Xu, Qiao Zhang, Zhanpeng Shang, Yanling Zhang, Qinghua Wu, Shiyou Li, Yanjiang Qiao
ETHNOPHARMACOLOGICAL RELEVANCE: The complexity of ingredients in traditional Chinese medical formulas and the limited consideration of toxicological responses are fundamental issues that hamper prognostic information of drug quality control. MATERIALS AND METHODS: A multidisciplinary approach for quality control of Qingkailing injection (QKL) regarding drug induced liver toxicity was described for the first time. High content image analysis (HCA) was combined with reverse-phase chromatographic separation and high-resolution MS detection technologies to provide the dynamic responses of HepG2 cell injury...
December 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29218852/psychotic-conversion-of-individuals-at-ultra-high-risk-for-psychosis-the-potential-roles-of-schizotypy-and-basic-symptoms
#5
Minji Bang, Jin Young Park, Kyung Ran Kim, Su Young Lee, Yun Young Song, Jee In Kang, Eun Lee, Suk Kyoon An
AIM: To improve strategies for the early identification of individuals at a heightened risk for the development of psychosis, we investigated the relationships and interactions between 3 psychosis-proneness dimensions for the development of schizophrenia spectrum psychosis: schizotypy, basic symptoms and the ultra-high risk (UHR) criteria. METHODS: Seventy-seven UHR individuals and 79 healthy controls were assessed for schizotypy and basic symptoms using self-report questionnaires at baseline...
December 8, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29210687/identification-and-risk-assessment-of-human-and-veterinary-antibiotics-in-the-wastewater-treatment-plants-and-the-adjacent-sea-in-tunisia
#6
Leyla Tahrani, Joris Van Loco, Roel Anthonissen, Luc Verschaeve, Hedi Ben Mansour, Tim Reyns
In the following study, we came up with and validated a prompt, sensitive and precise method for the simultaneous determination of 56 antimicrobial drugs (tetracyclines, sulfonamides, β-lactams, macrolides and quinolones) using the ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). This method was implemented with success to determine antibiotics in samples collected from four wastewater treatment plants and five coasts in Tunisia. Results showed the presence of high concentrations of antibiotics that ranged from 0...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29210608/occurrence-and-risk-assessment-of-population-exposed-to-deoxynivalenol-in-foods-derived-from-wheat-flour-in-brazil
#7
Milena Veronezi Silva, Giseli Cristina Pante, Jéssica Cristina Zoratto Romoli, Alexandra Perdigão Maia de Souza, Gustavo Henrique Oliveira da Rocha, Flavio Dias Ferreira, Adriane Lettnin Roll Feijó, Salesia Maria Prodócimo Moscardi, Karina Ruaro de Paula, Erika Bando, Samuel Botião Nerilo, Miguel Machinski
Deoxynivalenol (DON) is the most important of the trichothecenes in terms of amounts and occurrence in wheat. This compound was show to be associated with a glomerulonephropathy involving an increase of immunoglobulin A in humans. This study assessed the occurrence of DON in wheat flour and the exposure of Brazilian teenagers, adults and elderly to this mycotoxin due to intake of wheat flour-based products. DON extraction in wheat flour was carried out by solid phase extraction and the quantification was performed by ultra-high proficiency liquid chromatography with diode-array detection...
December 6, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29202107/a-multi-level-spatial-analysis-of-clinical-malaria-and-subclinical-plasmodium-infections-in-pailin-province-cambodia
#8
Daniel M Parker, Rupam Tripura, Thomas J Peto, Richard J Maude, Chea Nguon, Jeremy Chalk, Pasathorn Sirithiranont, Mallika Imwong, Lorenz von Seidlein, Nicholas J White, Arjen M Dondorp
Background: The malaria burden is decreasing throughout the Greater Mekong Subregion, however transmission persists in some areas. Human movement, subclinical infections and complicated transmission patterns contribute to the persistence of malaria. This research describes the micro-geographical epidemiology of both clinical malaria and subclinical Plasmodium infections in three villages in Western Cambodia. Methods: Three villages in Western Cambodia were selected for the study based on high reported Plasmodium falciparum incidence...
November 2017: Heliyon
https://www.readbyqxmd.com/read/29200971/vwf-adamts13-is-associated-with-on-aspirin-residual-platelet-reactivity-and-clinical-outcome-in-patients-with-stable-coronary-artery-disease
#9
Ellen M K Warlo, Alf-Åge R Pettersen, Harald Arnesen, Ingebjørg Seljeflot
Background: The mechanisms behind residual platelet reactivity (RPR) despite aspirin treatment are not established. It has been shown that coronary artery disease (CAD) patients with high on-aspirin RPR have elevated levels of von Willebrand factor (vWF). ADAMTS13 is a metalloprotease cleaving ultra large vWF multimers into less active fragments.Our aim was to investigate whether ADAMTS13 and vWF/ADAMTS13 ratio were associated with high RPR, and further with clinical endpoints after 2 years...
2017: Thrombosis Journal
https://www.readbyqxmd.com/read/29199440/annals-express-a-study-of-high-middle-and-low-molecular-weight-adiponectin-in-urine-as-a-surrogate-marker-for-early-diabetic-nephropathy-using-ultra-sensitive-ict-eia
#10
Mayumi Yamamoto, Yuki Hujimoto, Shino Hayashi, Seiichi Hashida
BACKGROUND: For the early identification of patients at risk of developing diabetic nephropathy, we have developed an ultra-sensitive immune complex transfer enzyme immunoassay (ICT-EIA) to measure adiponectin in urine. METHODS: We developed ICT-EIA for adiponectin and measured urinary adiponectin from 70 healthy subjects, 35 obese non-diabetic subjects and 20 patients with diabetes. RESULTS: The urinary adiponectin levels in patients with diabetes (3...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29198207/neuroanatomical-changes-in-people-with-high-schizotypy-relationship-to-glutamate-levels
#11
Gemma Modinos, Alice Egerton, Anna McLaughlin, Katrina McMullen, Veena Kumari, David J Lythgoe, Gareth J Barker, André Aleman, Steve C R Williams
BACKGROUND: Cortical glutamatergic dysfunction is thought to be fundamental for psychosis development, and may lead to structural degeneration through excitotoxicity. Glutamate levels have been related to gray matter volume (GMV) alterations in people at ultra-high risk of psychosis, and we previously reported GMV changes in individuals with high schizotypy (HS), which refers to the expression of schizophrenia-like characteristics in healthy people. This study sought to examine whether GMV changes in HS subjects are related to glutamate levels...
December 4, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29194473/esmo-consensus-conference-on-malignant-lymphoma-general-perspectives-and-recommendations-for-the-clinical-management-of-the-elderly-patient-with-malignant-lymphoma
#12
C Buske, M Hutchings, M Ladetto, V Goede, U Mey, P Soubeyran, M Spina, R Stauder, M Trnený, U Wedding, P Fields
The European Society for Medical Oncology (ESMO) consensus conference on mature B cell lymphomas and chronic lymphocytic leukaemia (CLL) was held on 20 June 2015 in Lugano, Switzerland, and included a multidisciplinary panel of 25 leading experts. The aim of the conference was to develop recommendations on critical subjects difficult to consider in detail in the ESMO Clinical Practice Guidelines. The following areas were identified: (1) the elderly patient, (2) prognostic factors suitable for clinical use, and (3) the 'ultra-high-risk' group...
November 29, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29192300/characterizing-an-ultra-high-risk-subset-of-patients-with-hypopharynx-and-larynx-cancer-the-power-of-lymph-node-burden
#13
Ryan K Orosco, Ezra E Cohen
No abstract text is available yet for this article.
November 30, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29179064/a-simple-and-highly-sensitive-uplc-esi-ms-ms-method-for-the-simultaneous-quantification-of-nicotine-cotinine-and-the-tobacco-specific-carcinogens-n-nitrosonornicotine-and-4-methylnitrosamino-1-3-pyridyl-1-butanone-in-serum-samples
#14
Lucie Loukotková, Linda S VonTungeln, Michelle Vanlandingham, Gonçalo Gamboa da Costa
According to the World Health Organization, the consumption of tobacco products is the single largest cause of preventable deaths in the world, exceeding the total aggregated number of deaths caused by diseases such as AIDS, tuberculosis, and malaria. An important element in the evaluation of the health risks associated with the consumption of tobacco products is the assessment of the internal exposure to the tobacco constituents responsible for their addictive (e.g. nicotine) and carcinogenic (e.g. N-nitrosamines such as NNN and NNK) properties...
November 21, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29174435/dopamine-in-high-risk-populations-a-comparison-of-subjects-with-22q11-2-deletion-syndrome-and-subjects-at-ultra-high-risk-for-psychosis
#15
Claudia Vingerhoets, Oswald J N Bloemen, Erik Boot, Geor Bakker, Mariken B de Koning, Fabiana da Silva Alves, Jan Booij, Thérèse A M J van Amelsvoort
Striatal dopamine (DA) dysfunction has been consistently reported in psychotic disorders. Differences and similarities in the pathogenesis between populations at clinical and genetic risk for developing psychosis are yet to be established. Here we explored markers of dopamine (DA) function in subjects meeting clinically ultra-high risk criteria for psychosis (UHR) and in subjects with 22q11.2 deletion syndrome (22q11DS), a genetic condition associated with significant risk for developing psychotic disorders...
November 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29169690/evaluation-of-surface-finish-and-dimensional-control-of-tribological-metal-ultra-high-molecular-weight-polyethylene-pair-of-commercially-available-hip-implants
#16
Patricia O Cubillos, Vinícius O Dos Santos, André Luiz A Pizzolatti, Edison da Rosa, Carlos R M Roesler
BACKGROUND: Dimensional control and surface finish of the femoral head and acetabular liner are critical factors in the manufacturing process due to the risk of increased polyethylene wear, which is the primary cause of aseptic failure of a metal/polymer hip prosthesis. The aim of this study is to perform a dimensional and surface finish analysis to evaluate the reproduction and accuracy of the manufacturing processes of metal femoral heads and ultra high molecular weight polyethylene acetabular liners...
November 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29169347/intermediate-psa-half-life-after-neoadjuvant-hormone-therapy-predicts-reduced-risk-of-castration-resistant-prostate-cancer-development-after-radical-prostatectomy
#17
Yong Jin Kang, Won Sik Jang, Jong Kyou Kwon, Cheol Yong Yoon, Joo Yong Lee, Won Sik Ham, Young Deuk Choi
BACKGROUND: The magnitude and rapidity of the tumor response to androgen deprivation is known to predict the durability of the therapy. We have investigated the predictive value of categorizing patients by the half-life of PSA under neoadjuvant androgen deprivation therapy in patients with biochemical recurrence after radical prostatectomy. METHODS: Medical records of 317 patients who received neoadjuvant androgen deprivation therapy before radical prostatectomy and developed biochemical recurrence were analyzed...
November 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29164799/suicidal-ideation-in-individuals-at-ultra-high-risk-for-psychosis-and-its-association-with-suspiciousness-independent-of-depression
#18
Minji Bang, Jin Young Park, Kyung Ran Kim, Su Young Lee, Yun Young Song, Jee In Kang, Eun Lee, Suk Kyoon An
AIM: Psychotic experiences, including delusions and hallucinations, and their attenuated forms have been recently suggested as a significant but under-recognized marker of suicide risk. However, the relationship between attenuated positive symptoms and suicide has not yet been clearly demonstrated in individuals at ultra-high risk (UHR) for psychosis. Here, we investigated the effect of attenuated positive symptoms on suicidal ideation in UHR individuals. METHODS: Fifty-three healthy controls (HCs) and 74 UHR individuals participated in the present study...
November 22, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29154207/particle-size-distribution-and-respiratory-deposition-estimates-of-airborne-perfluoroalkyl-acids-during-the-haze-period-in-the-megacity-of-shanghai
#19
Mengjie Guo, Yan Lyu, Tingting Xu, Bo Yao, Weihua Song, Mei Li, Xin Yang, Tiantao Cheng, Xiang Li
This study presents the particle size distribution and respiratory deposition estimates of airborne perfluoroalkyl acids (PFAAs) during the haze period. Size-segregated haze aerosols were collected from an urban location in Shanghai using an eight-stage air sampler. The samples were analyzed for eight PFAAs using ultra-high-performance liquid chromatography tandem triple quadrupole mass spectrometry. The quantification results showed that the concentrations of particle-bound Σ 8PFAAs ranged from 0.26 to 1...
November 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29146503/methodology-for-controlled-administration-of-smoked-synthetic-cannabinoids-jwh-018-and-jwh-073
#20
REVIEW
Ziva D Cooper, Justin L Poklis, Fei Liu
Synthetic cannabinoids (SCs) are a significant public health concern given their widespread use and severe effects associated with intoxication. However, there is a paucity of controlled human studies investigating the behavioral and physiological effects and pharmacokinetics of these compounds. Designing a reliable method to administer consistent, concentration-dependent synthetic cannabinoids is an integral component of controlled study of these compounds. Further, optimizing methods to assess the parent compounds and metabolites in plasma is critical in order to be able to establish their pharmacokinetics after administration...
November 13, 2017: Neuropharmacology
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