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https://www.readbyqxmd.com/read/29667156/how-we-manage-patients-with-plasmacytomas
#1
REVIEW
Despina Fotiou, Meletios A Dimopoulos, Efstathios Kastritis
PURPOSE OF REVIEW: To discuss the diagnostic approach, treatment options, and future considerations in the management of plasmacytomas, either solitary or in the context of overt multiple myeloma (MM). RECENT FINDINGS: Advanced imaging techniques such as whole-body magnetic resonance imaging and positron emission tomography/computerized tomography are essential for the diagnostic workup of solitary plasmacytomas (SP) to rule out the presence of other disease foci...
April 17, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29661523/a-positive-psychological-intervention-reduces-acute-psychosis-proneness
#2
Phillip Grant, Aisha Judith Leila Munk, Juergen Hennig
BACKGROUND: While individuals at ultra-risk for schizophrenia are characterized by high negative/disorganised but low positive schizotypy, schizophrenia patients are usually high in all three schizotypy facets. Thus, avoiding increases in positive schizotypy in ultra-high risk individuals may constitute of form of schizophrenia-prevention. A possible method of reducing positive schizotypy could be Positive-Psychological intervention (PI). METHODS: We present results from 2 independent studies, including a 12-month follow-up from study 1, using an easy-to-perform intervention based on Positive Psychology to reduce positive schizotypy...
April 13, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29653254/interactions-between-risk-factors-in-the-prediction-of-onset-of-eating-disorders-exploratory-hypothesis-generating-analyses
#3
Eric Stice, Christopher D Desjardins
OBJECTIVE: Because no study has tested for interactions between risk factors in the prediction of future onset of each eating disorder, this exploratory study addressed this lacuna to generate hypotheses to be tested in future confirmatory studies. METHOD: Data from three prevention trials that targeted young women at high risk for eating disorders due to body dissatisfaction (N = 1271; M age 18.5, SD 4.2) and collected diagnostic interview data over 3-year follow-up were combined to permit sufficient power to predict onset of anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED), and purging disorder (PD) using classification tree analyses, an analytic technique uniquely suited to detecting interactions...
March 17, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29626588/risk-of-gestational-diabetes-mellitus-in-relation-to-plasma-concentrations-of-amino-acids-and-acylcarnitines-a-nested-case-control-study
#4
Cynthia Roy, Pierre-Yves Tremblay, Elhadji Assanour-Laouan-Sidi, Michel Lucas, Jean-Claude Forest, Yves Giguère, Pierre Ayotte
AIMS: Gestational diabetes mellitus (GDM) affects between 5 to 10 % of all pregnancies in Canada and can lead to adverse health outcomes in both the mother and fetus. Amino acids (AA) and acylcarnitines (AC) have been identified as early biomarkers of type 2 diabetes but their usefulness in screening for GDM has yet to be demonstrated. METHODS: We conducted a nested case-control study involving 50 controls and 50 GDM cases diagnosed between the 24th and 28th week of gestation...
April 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29620817/evaluating-the-managed-care-implications-of-longer-acting-basal-insulin-analog-therapies
#5
Tripp Logan, Bianca Daisy
Diabetes, particularly type 2 diabetes (T2D), has become an epidemic in the United States, with a significant portion of patients unable to meet recommended glycemic targets. All individuals with type 1 diabetes (T1D) and a significant majority of those with T2D will ultimately require insulin therapy. However, there are several barriers to its use. The introduction of the new, ultra-long-acting basal insulins degludec and glargine U-300, and the single-injection combinations of insulin degludec/liraglutide and insulin glargine U-100/lixisenatide, offer options that may overcome several of those barriers, including the high risk of hypoglycemia, glycemic variability, and relatively short duration of action...
March 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29606150/stereotactic-ablative-radiotherapy-for-ultra-central-lung-tumors-prioritize-target-coverage-or-organs-at-risk
#6
Donna H Murrell, Joanna M Laba, Abigail Erickson, Barbara Millman, David A Palma, Alexander V Louie
BACKGROUND: Lung stereotactic ablative radiotherapy (SABR) is associated with low morbidity, however there is an increased risk of treatment-related toxicity in tumors directly abutting or invading the proximal bronchial tree, termed 'ultra-central' tumors. As there is no consensus regarding the optimal radiotherapy treatment regimen for these tumors, we performed a modeling study to evaluate the trade-offs between predicted toxicity and local control for commonly used high-precision dose-fractionation regimens...
April 2, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29587434/qualitative-and-quantitative-analysis-of-polyphenols-in-lamiaceae-plants-a-review
#7
REVIEW
Katerina Tzima, Nigel P Brunton, Dilip K Rai
Lamiaceae species are promising potential sources of natural antioxidants, owing to their high polyphenol content. In addition, increasing scientific and epidemiological evidence have associated consumption of foods rich in polyphenols with health benefits such as decreased risk of cardiovascular diseases mediated through anti-inflammatory effects. The complex and diverse nature of polyphenols and the huge variation in their levels in commonly consumed herbs make their analysis challenging. Innovative robust analytical tools are constantly developing to meet these challenges...
March 26, 2018: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29584866/levels-of-serum-brain-derived-neurotropic-factor-in-individuals-at-ultra-high-risk-for-psychosis-findings-from-the-longitudinal-youth-at-risk-study-lyriks
#8
Jie Yin Yee, Tih-Shih Lee, Jimmy Lee
Background: Identifying biomarkers to enrich prognostication and risk predictions in individuals at high risk of developing psychosis will enable stratified early intervention efforts. Brain-derived neurotrophic factor (BDNF) has been widely studied in schizophrenia and in first-episode psychosis with promising results. The aim of this study was to examine the levels of serum BDNF between healthy controls and individuals with ultra-high risk of psychosis (UHR). Methods: A sample of 106 healthy controls and 105 UHR individuals from the Longitudinal Youth at Risk Study was included in this study...
March 23, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29581207/cross-sectional-associations-of-objectively-assessed-neighbourhood-attributes-with-depressive-symptoms-in-older-adults-of-an-ultra-dense-urban-environment-the-hong-kong-alecs-study
#9
Casper J P Zhang, Anthony Barnett, Cindy H P Sit, Poh-Chin Lai, Janice M Johnston, Ruby S Y Lee, Ester Cerin
OBJECTIVES: This study aimed to examine the associations between objectively assessed neighbourhood environmental attributes and depressive symptoms in Hong Kong Chinese older adults and the moderating effects of neighbourhood environmental attributes on the associations between living arrangements and depressive symptoms. DESIGN: Cross-sectional observational study. SETTING: Hong Kong. PARTICIPANTS: 909 Hong Kong Chinese community dwellers aged 65+ years residing in preselected areas stratified by walkability and socioeconomic status...
March 25, 2018: BMJ Open
https://www.readbyqxmd.com/read/29569019/prediction-of-breast-cancer-risk-with-volatile-biomarkers-in-breath
#10
Michael Phillips, Renee N Cataneo, Jose Alfonso Cruz-Ramos, Jan Huston, Omar Ornelas, Nadine Pappas, Sonali Pathak
BACKGROUND: Human breath contains volatile organic compounds (VOCs) that are biomarkers of breast cancer. We investigated the positive and negative predictive values (PPV and NPV) of breath VOC biomarkers as indicators of breast cancer risk. METHODS: We employed ultra-clean breath collection balloons to collect breath samples from 54 women with biopsy-proven breast cancer and 124 cancer-free controls. Breath VOCs were analyzed with gas chromatography (GC) combined with either mass spectrometry (GC MS) or surface acoustic wave detection (GC SAW)...
March 23, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29567371/a-pilot-study-on-immuno-psychiatry-in-the-22q11-2-deletion-syndrome-a-role-for-th17-cells-in-psychosis
#11
Elfi Vergaelen, Carmen Schiweck, Kristof Van Steeland, Jacqueline Counotte, Wim Veling, Ann Swillen, Hemmo Drexhage, Stephan Claes
BACKGROUND: A growing body of evidence supports a role for immune alterations in Schizophrenia Spectrum Disorders (SSD). A high prevalence (25% - 40%) of SSD has been found in patients with 22q11.2 deletion syndrome (22q11.2DS), which is known for T-cell deficits due to thymus hypoplasia. This study is the first to explore the association between the T-cell subsets and psychotic symptoms in adults with 22q11.2DS. METHODS: 34 individuals (aged 19-38 yrs.) with 22q11...
March 19, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29549740/development-and-validation-of-an-ultra-high-performance-liquid-chromatography-electrospray-tandem-mass-spectrometry-method-using-selective-derivatisation-for-the-quantification-of-two-reactive-aldehydes-produced-by-lipid-peroxidation-hne-4-hydroxy-2-e-nonenal
#12
S Chevolleau, M-H Noguer-Meireles, I Jouanin, N Naud, F Pierre, F Gueraud, L Debrauwer
Red or processed meat rich diets have been shown to be associated with an elevated risk of colorectal cancer (CRC). One major hypothesis involves dietary heme iron which induces lipid peroxidation. The quantification of the resulting reactive aldehydes (e.g. HNE and HHE) in the colon lumen is therefore of great concern since these compounds are known for their cytotoxic and genotoxic properties. UHPLC-ESI-MS/MS method has been developed and validated for HNE and HHE quantification in rat faeces. Samples were derivatised using a brominated reagent (BBHA) in presence of pre-synthesized deuterated internal standards (HNE-d11/HHE-d5), extracted by solid phase extraction, and then analysed by LC-positive ESI-MS/MS (MRM) on a TSQ Vantage mass spectrometer...
March 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29535624/urinary-8-oxo-7-8-dihydroguanosine-as-a-potential-biomarker-of-aging
#13
Wei Gan, Xin-Le Liu, Ting Yu, Yuan-Gao Zou, Ting-Ting Li, Shuang Wang, Jin Deng, Lan-Lan Wang, Jian-Ping Cai
Background: A molecular biomarker of physiologic age, as opposed to chronologic age, is needed in clinical medicine. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGsn) and 8-oxo-7, 8-dihydroguanosine (8-oxoGsn) are two promising aging biomarkers. Methods: A total of 1,228 healthy Chinese residents (613 males and 615 females) 2-90 years of age were randomly selected. Spot urine samples were collected, and the concentrations of 8-oxodGsn and 8-oxoGsn were measured using ultra-high-performance liquid chromatography with a triple quadrupole mass spectrometer (UPLC-MS/MS)...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29529009/quantification-of-idelalisib-in-human-plasma-by-ultra-performance-liquid-chromatography-coupled-to-mass-spectrometry-in-negative-ionization-mode
#14
Huu H Huynh, Clara Roessle, Hélène Sauvageon, Alain Plé, Isabelle Madelaine, Catherine Thieblemont, Samia Mourah, Lauriane Goldwirt
BACKGROUND: Idelalisib is the first orally active selective phosphatidylinositol 3-kinase delta inhibitor approved by Food and Drug Administration and European Medicines Agency in 2014 for the treatment of several types of blood cancer. Idelalisib is widely used as a monotherapy or in combination with rituximab, bendamustine, or ofatumumab with a significant efficacy. However, idelalisib has shown increased risk of infection and a higher frequency of serious adverse events. It may be useful to determine idelalisib concentration in human plasma to adjust dose and to manage adverse effects in clinical practice...
April 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29525659/occurrence-of-benzothiazole-and-its-derivates-in-tire-wear-road-dust-and-roadside-soil
#15
Jing Zhang, Xinfeng Zhang, Lin Wu, Ting Wang, Jingbo Zhao, Yanjie Zhang, Zhengyu Men, Hongjun Mao
Benzothiazole (BT) and its derivates are commonly used as vulcanization accelerators in rubber production. Information on the occurrence of BTs in road dust (RD) and on human exposure to these compounds is very limited. BT and its six derivates in tire wear particles (TWPs) and RD were determined in this study. Samples were extracted using solid-liquid extraction, purified by a HLB SPE column, and determined by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). All seven BTs were found in 17 TWPs samples from different tire brands...
March 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29524969/identifying-and-managing-the-risks-of-medical-ionizing-radiation-in-endourology
#16
Todd Yecies, Timothy D Averch, Michelle J Semins
INTRODUCTION: The risks of exposure to medical ionizing radiation is of increasing concern both among medical professionals and the general public. Patients with nephrolithiasis are exposed to high levels of ionizing radiation through both diagnostic and therapeutic modalities. Endourologists who perform a high-volume of fluoroscopy guided procedures are also exposed to significant quantities of ionizing radiation. The combination of judicious use of radiation-based imaging modalities, application of new imaging techniques such as ultra-low dose computed tomography (CT) scan, and modifying use of current technology such as increasing ultrasound and pulsed fluoroscopy utilization offers the possibility of significantly reducing radiation exposure...
February 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29513141/seasonal-distribution-characteristics-and-health-risk-assessment-of-typical-antibiotics-in-the-harbin-section-of-the-songhua-river-basin
#17
Weihua Wang, Wanfeng Zhang, Hong Liang, Dawen Gao
A method was established for coupled solid phase extraction-ultra performance liquid chromatography and mass spectrometry, to simultaneously detect 12 common antibiotics belonging to 4 types (sulfonamides, macrolides, fluoroquinolones and cephalosporins) in surface water environments. The characteristic distribution and seasonal variation in antibiotic content was investigated in the Harbin section of the Songhua River basin, Northeastern China. The results showed that the 12 antibiotics monitored were all detected to varying degrees, with 100% detection rates for sulfamethoxazole (SMX), cefazolin (CFZ), ofloxacin (OFL), flumequine (FLU), azithromycin (AZI) and roxithromycin (ROX) in all sampling sites...
March 7, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29512832/a-preliminary-validation-study-of-two-ultra-brief-measures-of-suicide-risk-the-suicide-and-perceived-burdensomeness-visual-analog-scales
#18
Craig J Bryan
The advent of rapid-acting suicide-focused interventions and longitudinal research designs employing high-frequency, repeated measurement of suicide risk has resulted in a need to quantify suicide risk during very brief windows of time (e.g., minutes, hours, days). This has rapidly outpaced traditional methods for assessing suicide risk, which often focus on measuring indicators of suicide risk during much broader intervals of time (e.g., weeks to months). Valid and practical methods for rapidly assessing suicide risk during small time intervals are therefore needed...
March 7, 2018: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29512314/exploring-functional-impairment-in-young-people-at-ultra-high-risk-for-psychosis-a-qualitative-study
#19
Jack Cotter, Sandra Bucci, Richard J Drake, Alison R Yung, Rebekah Carney, Dawn Edge
AIM: Many young people at ultra-high risk (UHR) of developing psychosis exhibit marked and persistent impairments in social and occupational functioning. We aimed to explore UHR patients' subjective experiences of these difficulties and their causes. METHODS: We conducted semi-structured interviews with 20 UHR individuals recruited from Early Detection and Intervention Teams in Northwest England. Topics covered included how participants spent their time, their interpersonal relationships, academic and occupational performance, premorbid functioning and clinical treatment...
March 7, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29506584/core-beliefs-in-healthy-youth-and-youth-at-ultra-high-risk-for-psychosis-dimensionality-and-links-to-depression-anxiety-and-attenuated-psychotic-symptoms
#20
Henry R Cowan, Dan P McAdams, Vijay A Mittal
Cognitive theory posits that core beliefs play an active role in developing and maintaining symptoms of depression, anxiety, and psychosis. This study sought to comprehensively examine core beliefs, their dimensionality, and their relationships to depression, anxiety, and attenuated psychotic symptoms in two groups of community youth: a group at ultrahigh risk for psychosis (UHR; n = 73, M age = 18.7) and a matched healthy comparison group (HC; n = 73, M age = 18.1). UHR youth reported significantly more negative beliefs about self and others, and significantly less positive beliefs about self and others...
March 6, 2018: Development and Psychopathology
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