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https://www.readbyqxmd.com/read/29447074/social-cognition-in-the-course-of-psychosis-and-its-correlation-with-biomarkers-in-a-male-cohort
#1
Evangelos Ntouros, Evangelos Karanikas, Georgios Floros, Christina Andreou, Aikaterini Tsoura, Georgios Garyfallos, Vasilios P Bozikas
INTRODUCTION: Patients diagnosed with schizophrenia display deficits in Theory of Mind (ToM) and Emotion Perception (EP) even before the appearance of full-blown symptomatology. METHODS: We evaluated ToM and EP in a male cohort consisting of 25 First Episode Psychosis (FEP) and 16 relapsed schizophrenic patients (CHRON) compared to 12 subjects in Ultra-high Risk (UHR) and 23 healthy controls (CTR). Furthermore, we measured the levels of Cortisol, Insulin like Growth Factor (IGF-1), TNF-a, TNF-b and several interleukins as potential biomarkers...
February 15, 2018: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/29440719/prefrontal-gaba-levels-hippocampal-resting-perfusion-and-the-risk-of-psychosis
#2
Gemma Modinos, Fatma Şimşek, Matilda Azis, Matthijs Bossong, Ilaria Bonoldi, Carly Samson, Beverly Quinn, Jesus Perez, Matthew R Broome, Fernando Zelaya, David J Lythgoe, Oliver D Howes, James M Stone, Anthony A Grace, Paul Allen, Philip McGuire
Preclinical models propose that the onset of psychosis is associated with hippocampal hyperactivity, thought to be driven by cortical GABAergic interneuron dysfunction and disinhibition of pyramidal neurons. Recent neuroimaging studies suggest that resting hippocampal perfusion is increased in subjects at ultra-high risk (UHR) for psychosis, but how this may be related to GABA concentrations is unknown. The present study used a multimodal neuroimaging approach to address this issue in UHR subjects. Proton magnetic resonance spectroscopy and pulsed-continuous arterial spin labeling imaging were acquired to investigate the relationship between medial prefrontal (MPFC) GABA+ levels (including some contribution from macromolecules) and hippocampal regional cerebral blood flow (rCBF) in 36 individuals at UHR of psychosis, based on preclinical evidence that MPFC dysfunction is involved in hippocampal hyperactivity...
January 30, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29424457/a-point-of-care-diagnostic-system-to-influenza-viruses-using-chip-based-ultra-fast-pcr
#3
Soon-Hwan Kwon, Sujin Lee, Jeyoun Jang, Yujin Seo, Hee-Young Lim
In order to diagnose the infectious disease from clinical samples, the various protocols such as culturing microorganism, rapid diagnostic test using chromatographic method, ELISA, conventional PCR are developed. Since a novel strain of avian influenza can be cross-infected human as well as birds and livestock due to genetic reassortment, some strains of influenza such as H7N9 and H5N1 have emerged as a severe virus which can be threaten the health of poultry as well as human. Therefore we explored the development of simultaneously and rapid diagnostic tool for seasonal influenza (A/H1N1, A/H3N2, B) and highly pathogenic avian influenza (A/H5N1, A/H7N9)...
February 9, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29421973/multimodal-characterization-of-the-late-effects-of-tbi-letbi-a-methodological-overview-of-the-letbi-project
#4
Brian L Edlow, C Dirk Keene, Daniel Perl, Diego Iacono, Rebecca Folkerth, William Stewart, Christine L MacDonald, Jean Augustinack, Ramon Diaz-Arrastia, Camilo Estrada, Elissa Flannery, Wayne Gordon, Tom Grabowski, Kelly Hansen, Jeanne Hoffman, Christopher Kroenke, Eric Larson, Patricia Lee, Azma Mareyam, Jennifer A McNab, Jeanne McPhee, Allison L Moreau, Anne Renz, KatieRose Richmire, Allison Stevens, Cheuk Y Tang, Lee S Tirrell, Emily Trittschuh, Andre van der Kouwe, Ani Varjabedian, Lawrence L Wald, Ona Wu, Anastasia Yendiki, Liza Young, Lilla Zollei, Bruce Fischl, Paul K Crane, Kristen Dams-O'Connor
Epidemiological studies suggest that a single moderate-to-severe traumatic brain injury (TBI) is associated with an increased risk of neurodegenerative disease, including Alzheimer's and Parkinson's disease (AD and PD). Histopathological studies describe complex neurodegenerative pathologies in individuals exposed to single moderate-to-severe TBI or repetitive mild TBI, including chronic traumatic encephalopathy (CTE). However, the clinicopathological links between TBI and post-traumatic neurodegenerative diseases such as AD, PD, and CTE remain poorly understood...
February 8, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29419350/swim-exercise-training-ameliorates-hepatocyte-ultrastructural-alterations-in-rats-fed-on-a-high-fat-and-sugar-diet
#5
Mohammed A Dallak, Ismaeel Bin-Jaliah, Alia Albawardi, Mohamed A Haidara, Hussein F Sakr, Refaat A Eid, W N Hassan, Bahjat Al-Ani
Excessive consumption of carbohydrate and fat increases the risk of liver disease. We hypothesized that swim exercise can protect hepatocytes from ultra-structural damage induced by high cholesterol and fructose diets (HCFD). Rats were either fed with HCFD (model group) or a standard laboratory chow (control group) for 15 weeks before being sacrificed. Swim exercise trained rats started the treatment from the 11th week until the sacrifice day, end of week 15. Blood samples were assayed for biomarkers of liver injury and adiponectin...
February 8, 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29411558/interactions-between-bisphenol-a-exposure-and-gstp1-polymorphisms-in-childhood-asthma
#6
Tien Jen Lin, Wilfried J J Karmaus, Mei Lien Chen, Jiin Chyr Hsu, I Jen Wang
PURPOSE: Bisphenol A (BPA) exposure may increase the risk of asthma. Genetic polymorphisms of oxidative stress-related genes, glutathione S-transferases (GSTM1, GSTP1), manganese superoxide dismutase, catalase, myeloperoxidase, and microsomal epoxide hydrolase may be related to BPA exposure. The aim is to evaluate whether oxidative stress genes modulates associations of BPA exposure with asthma. METHODS: We conducted a case-control study comprised of 126 asthmatic children and 327 controls...
March 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29410313/motor-dysfunction-as-research-domain-in-the-period-preceding-manifest-schizophrenia-a-systematic-review
#7
REVIEW
Dusan Hirjak, Andreas Meyer-Lindenberg, Katharina M Kubera, Philipp A Thomann, Robert C Wolf
Schizophrenia is a severe behavioral syndrome of neurodevelopmental nature marked by primary or genuine motor abnormalities (GMA), which refer to spontaneous and medication-independent motor phenomena. Since motor dysfunction thus might be a consequence of events occurring during early childhood and adolescence, GMA can be detected in the period preceding manifest schizophrenia. However, the question whether motor system dysfunction might be a promising motor intermediate phenotype for schizophrenia remains unanswered...
February 2, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29407696/trace-analysis-of-61-natural-and-synthetic-progestins-in-river-water-and-sewage-effluents-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#8
Xiaoyan Shen, Hong Chang, Dezhi Sun, Linxia Wang, Fengchang Wu
A broad number of natural and synthetic progestins are widely used in human and veterinary therapies. Although progestins exhibit adverse effects in aquatic organisms, information about environmental occurrence and fate have been limited to several compounds, hampering the accuracy of risk assessments of the compounds. In this study, a selective and sensitive analytical method was established to simultaneously determine 19 natural and 42 synthetic progestins in environmental waters, and the synthetic progestins included 19-nortestosterone, 17α-hydroxyprogesterone and progesterone derivatives...
February 1, 2018: Water Research
https://www.readbyqxmd.com/read/29393219/ultra-low-contrast-volume-for-patients-with-advanced-chronic-kidney-disease-undergoing-coronary-procedures
#9
Zach Rozenbaum, Sydney Benchetrit, Eliezer Rozenbaum, Eran Neumark, Morris Mosseri, David Pereg
BACKGROUND/AIMS: Contrast induced nephropathy (CIN) is associated with adverse clinical outcomes in patients undergoing coronary interventions, particularly in patients with advanced chronic kidney. The study was aimed to assess the real-life feasibility and safety of ultra-low volume coronary procedures in patients with advanced chronic kidney disease. METHODS: A prospective study that included patients with an estimated glomerular filtration rate (eGFR) <45 mL/min/1...
January 24, 2018: Nephron
https://www.readbyqxmd.com/read/29390044/serum-metabolomic-profiling-of-all-cause-mortality-a-prospective-analysis-in-the-alpha-tocopherol-beta-carotene-cancer-prevention-atbc-study-cohort
#10
Jiaqi Huang, Stephanie J Weinstein, Steven C Moore, Andriy Derkach, Xing Hua, Linda M Liao, Fangyi Gu, Alison M Mondul, Joshua N Sampson, Demetrius Albanes
Tobacco use, hypertension, hyperglycemia, overweight, and inactivity are leading causes of overall and cardiovascular disease (CVD) mortality worldwide, yet the relevant metabolic alterations responsible are largely unknown. We conducted a serum metabolomic analysis of 620 men in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (1985-2013). During 28 years of follow-up, there were 435 deaths (197 CVD and 107 cancer). The analysis included 406 known metabolites measured with ultra-high performance liquid chromatography/mass spectrometry-gas chromatography/mass spectrometry...
January 30, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29389882/validation-of-a-method-for-cylindrospermopsin-determination-in-vegetables-application-to-real-samples-such-as-lettuce-lactuca-sativa-l
#11
Ana I Prieto, Remedios Guzmán-Guillén, Leticia Díez-Quijada, Alexandre Campos, Vitor Vasconcelos, Ángeles Jos, Ana M Cameán
Reports on the occurrence of the cyanobacterial toxin cylindrospermopsin (CYN) have increased worldwide because of CYN toxic effects in humans and animals. If contaminated waters are used for plant irrigation, these could represent a possible CYN exposure route for humans. For the first time, a method employing solid phase extraction and quantification by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) of CYN was optimized in vegetables matrices such as lettuce (Lactuca sativa)...
February 1, 2018: Toxins
https://www.readbyqxmd.com/read/29378427/ultra-obligatory-running-among-ultramarathon-runners
#12
Martin D Hoffman, Rhonna Krouse
Participants in the Ultrarunners Longitudinal TRAcking (ULTRA) Study were asked to answer "yes" or "no" to the question "If you were to learn, with absolute certainty, that ultramarathon running is bad for your health, would you stop your ultramarathon training and participation?" Among the 1349 runners, 74.1% answered "no". Compared with those answering "yes", they were younger (p < 0.0001), less likely to be married (p = 0.019), had less children (p = 0.0095), had a lower health orientation (p < 0...
January 29, 2018: Research in Sports Medicine
https://www.readbyqxmd.com/read/29377873/arc-of-riolan-preserving-splenic-flexure-takedown-during-anterior-resection-potentially-critical-to-prevent-acute-anastomotic-ischemia
#13
James Wei Tatt Toh, Ronnie Matthews, Seon-Hahn Kim
INTRODUCTION: The Arc of Riolan is a strategic vessel that provides collateral mesenteric circulation in 10% of individuals. The importance of identifying and preserving the arc of Riolan in reducing the risk of ischemia to the proximal anastomotic segment after high ligation anterior resection was evaluated. TECHNIQUE: The arc of Riolan is a vessel that crosses anterior to the inferior mesenteric vein horizontally below the level of the pancreas. A retrospective review of all recorded videos of laparoscopic and robotic low and ultra-low anterior resections was performed in September to December 2012 and prospective evaluation in April to July 2013...
March 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29376146/adamts13-deficiency-worsens-colitis-and-exogenous-adamts13-administration-decreases-colitis-severity-in-mice
#14
Naamah L Zitomersky, Melanie Demers, Kimberly Martinod, Maureen Gallant, Stephen M Cifuni, Amlan Biswas, Scott Snapper, Denisa D Wagner
Background: Inflammatory bowel disease (IBD) affects 1.6 million people in the United States. IBD is associated with an increased risk of thrombosis, which rises with disease activity. The pathogenesis of IBD and its increased thrombotic risk is not completely understood. Ultra large von Willebrand factor (ULVWF) multimers are secreted from activated endothelium, leading to recruitment of platelets and leukocytes. A disintegrin and metalloproteinase with thrombospondin type I repeats motif 13 (ADAMTS13) cleaves highly adhesive ULVWF into smaller, less bioactive, multimers, releasing them into circulation...
June 2017: TH Open: Companion Journal to Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29370357/ultra-fast-track-minimally-invasive-aortic-valve-replacement-going-beyond-reduced-incisions
#15
Marco Di Eusanio, Walter Vessella, Roberto Carozza, Filippo Capestro, Alessandro D'Alfonso, Carlo Zingaro, Christopher Munch, Paolo Berretta
Aortic valve replacement (AVR) via a median sternotomy approach has been largely reported to be safe and long-term efficacious, and currently represents the 'gold standard' approach for aortic stenosis treatment. However, aortic valve surgery has undergone continuous development over the last years, involving less invasive techniques and new technologies to reduce the traumatic impact of the intervention and extend the operability toward increasingly high-risk patients. Indeed, minimally invasive AVR and transcatheter aortic valve replacement caseload have steadily increased leading to a paradigm shift in the treatment of aortic valve disease...
January 23, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29367982/association-of-fatty-acids-and-lipids-metabolism-in-placenta-with-early-spontaneous-pregnancy-loss-in-chinese-women
#16
Kelei Li, Xiaotian Zhang, Gong Chen, Lijun Pei, Hailong Xiao, Jiajing Jiang, Jiaomei Li, Xiaoying Zheng, Duo Li
The aim of the present study was to evaluate the association of fatty acids and lipids metabolism in placenta with early spontaneous pregnancy loss (ESPL) in Chinese women. Seventy women with ESPL and 29 healthy pregnant women who asked for legal induced abortion were included in the case and control groups, respectively. The gestational age of the subject foetuses in both the case and control groups ranged from 4 to 10 weeks. The total fatty acids composition in the decidual and villous tissues was detected by gas-liquid chromatography using a standard method...
January 25, 2018: Food & Function
https://www.readbyqxmd.com/read/29358438/study-protocol-for-a-prospective-cohort-study-examining-the-predictive-potential-of-dynamic-symptom-networks-for-the-onset-and-progression-of-psychosis-the-mapping-individual-routes-of-risk-and-resilience-mirorr-study
#17
Sanne H Booij, Marieke Wichers, Peter de Jonge, Sjoerd Sytema, Jim van Os, Lex Wunderink, Johanna T W Wigman
INTRODUCTION: Our current ability to predict the course and outcome of early psychotic symptoms is limited, hampering timely treatment. To improve our understanding of the development of psychosis, a different approach to psychopathology may be productive. We propose to reconceptualise psychopathology from a network perspective, according to which symptoms act as a dynamic, interconnected system, impacting on each other over time and across diagnostic boundaries to form symptom networks...
January 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29352556/what-causes-psychosis-an-umbrella-review-of-risk-and-protective-factors
#18
Joaquim Radua, Valentina Ramella-Cravaro, John P A Ioannidis, Abraham Reichenberg, Nacharin Phiphopthatsanee, Taha Amir, Hyi Yenn Thoo, Dominic Oliver, Cathy Davies, Craig Morgan, Philip McGuire, Robin M Murray, Paolo Fusar-Poli
Psychosis is a heterogeneous psychiatric condition for which a multitude of risk and protective factors have been suggested. This umbrella review aimed to classify the strength of evidence for the associations between each factor and psychotic disorders whilst controlling for several biases. The Web of Knowledge database was searched to identify systematic reviews and meta-analyses of observational studies which examined associations between socio-demographic, parental, perinatal, later factors or antecedents and psychotic disorders, and which included a comparison group of healthy controls, published from 1965 to January 31, 2017...
February 2018: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/29352548/prediction-of-psychosis-across-protocols-and-risk-cohorts-using-automated-language-analysis
#19
Cheryl M Corcoran, Facundo Carrillo, Diego Fernández-Slezak, Gillinder Bedi, Casimir Klim, Daniel C Javitt, Carrie E Bearden, Guillermo A Cecchi
Language and speech are the primary source of data for psychiatrists to diagnose and treat mental disorders. In psychosis, the very structure of language can be disturbed, including semantic coherence (e.g., derailment and tangentiality) and syntactic complexity (e.g., concreteness). Subtle disturbances in language are evident in schizophrenia even prior to first psychosis onset, during prodromal stages. Using computer-based natural language processing analyses, we previously showed that, among English-speaking clinical (e...
February 2018: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/29338796/cortical-morphology-development-in-patients-with-22q11-2-deletion-syndrome-at-ultra-high-risk-of-psychosis
#20
Maria Carmela Padula, Marie Schaer, Marco Armando, Corrado Sandini, Daniela Zöller, Elisa Scariati, Maude Schneider, Stephan Eliez
BACKGROUND: Patients with 22q11.2 deletion syndrome (22q11DS) present a high risk of developing psychosis. While clinical and cognitive predictors for the conversion towards a full-blown psychotic disorder are well defined and largely used in practice, neural biomarkers do not yet exist. However, a number of investigations indicated an association between abnormalities in cortical morphology and higher symptoms severities in patients with 22q11DS. Nevertheless, few studies included homogeneous groups of patients differing in their psychotic symptoms profile...
January 17, 2018: Psychological Medicine
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