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Ultra high risk

Jiawei Hu, Caixia Wang, Li Tian, Minjuan Wang, Rong Guo, Haiou Qiao
OBJECTIVE: To investigate the contamination of zearalenone in food in Shaanxi Province, and to assess the dietary zearalenone exposure and the health risk of intaking zearalenone from corn products for Shaanxi residents. METHODS: In 2013-2016, samples of five kinds of food including grains, vegetable oil, liquor and infants' food were collected randomly from ten cities, and determined with ultra-performance liquid chromatography. Dietary intake assessment of human exposure to zearalenone was carried out in combination of food consumption data with concentration of zearalenone...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
Jamal Rahmani, Solmaz Alipour, Ali Miri, Yadolah Fakhri, Seyed-Mohammad Riahi, Hassan Keramati, Masoud Moradi, Nazak Amanidaz, Rokhsane Hosseini Pouya, Zohreh Bahmani, Amin Mousavi Khaneghah
The current investigation was undertaken to take a review of the performed studies regarding the concentration and prevalence of aflatoxin M1 (AFM1 ) of the consumed cow milk in the Middle East. In this context, all available studies published in databases include Science Direct, PubMed, Scopus, and Web of Science among 1995 to December 2017; were screened accordingly. Also, the carcinogenic risk was estimated by calculating hazard index (HI) using the Monte Carlo simulation (MCS). The result of conducted meta-analysis for 49 articles containing 7484 data indicated that the rank order of type of milk based on the concentration of aflatoxin M1 was Ultra-high temperature processing (UHT) milk (82...
June 11, 2018: Food and Chemical Toxicology
Frida Dangardt, Marietta Charakida, Scott Chiesa, Devina Bhowruth, Alicja Rapala, Daniela Thurn, Franz Schaefer, John Deanfield, Rukshana Shroff
BACKGROUND: Patients with chronic kidney disease (CKD) are exposed to both traditional 'Framingham' and uremia related cardiovascular risk factors that drive atherosclerotic and arteriosclerotic disease, but these cannot be differentiated using conventional ultrasound. We used ultra-high-frequency ultrasound (UHFUS) to differentiate medial thickness (MT) from intimal thickness (IT) in CKD patients, identify their determinants and monitor their progression. METHODS: Fifty-four children and adolescents with CKD and 12 healthy controls underwent UHFUS measurements using 55-70MHz transducers in common carotid and dorsal pedal arteries...
2018: PloS One
Shuhui Zhang, Xiaodong Liu, Mingzhu Sun, Qiuping Zhang, Teng Li, Xiang Li, Jia Xu, Xin Zhao, Dongyan Chen, Xizeng Feng
BACKGROUND: With increased social pressure, individuals face a high risk of depression. Subsequently, depression affects cognitive behaviour and negatively impacts daily life. Fortunately, the Traditional Chinese Medicine Jia Wei Xiao Yao (JWXY) capsule is effective in reducing depression and improving cognitive behaviour. METHODS: The constituents of JWXY capsule were identified by ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry analyses...
June 14, 2018: Behavioral and Brain Functions: BBF
Chih-Zong Deng, Yu-Jui Fan, Pei-Shan Chung, Horn-Jiunn Sheen
In this study, we developed a new immunosensor that can achieve an ultra-low detection limit and high sensitivity. This new device has an electrokinetic trapping (EKT)-based nanofluidic preconcentrator, which was integrated with oscillating bubble valves, to trap concentrated antigen and immunobeads. During the immunoassay process, oscillating bubbles rapidly grew and acted as control valves and to block the microchannel. Thereafter, the trapped preconcentrated antigen plug and antibody-coated nanobeads were preserved in the region between these two valves...
June 11, 2018: ACS Sensors
Owen J Diamond, Lisa Howard, Bassam Masri
BACKGROUND: Fracture of a polyethylene tibial post after a posterior stabilized total knee arthroplasty (PS-TKA) is an uncommon but severe complication. We report five cases of non-traumatic fracture of a tibial polyethylene post that occurred with Prolong highly cross-linked polyethylene with the NexGen LPS-Flex total knee prosthesis. METHODS: A Joint Reconstruction database for a high volume arthroplasty unit was used to identify all cases of revision of Prolong polyethylene used in PS-TKA...
June 5, 2018: Knee
Eşref Demir, Ricard Marcos
Graphene and multi-walled carbon nanotubes (MWCNT) are widely used in nanomedicine, and other fields, due to their unique physicochemical properties including high tensile strength, ultra-light weight, thermal and chemical stability, and reliable semi-conductive electronic properties. Although extensive amount of data exist describing their adverse effects including potential genotoxicity, few studies using gene mutation detection approaches in mammalian cells are available, which represents an important gap for risk estimations...
June 6, 2018: Journal of Toxicology and Environmental Health. Part A
Simon Rice, Andrea Polari, Andrew Thompson, Jessica Hartmann, Patrick McGorry, Barnaby Nelson
AIM: To examine reasons for referral to a specialist ultra-high risk (UHR) for psychosis clinic and whether these reasons are associated with risk for subsequent transition to psychosis. METHODS: Data for 127 patients referred to the Personal Assessment and Crisis Evaluation clinic were collected by medical record audit. Time to transition to psychosis was calculated from date of referral to time at which the young person was judged by their treating team to be experiencing onset of first episode psychosis...
June 6, 2018: Early Intervention in Psychiatry
Evgenia Preka, Bruno Ranchin, Anke Doyon, Melody Vierge, Tiphanie Ginhoux, Behrouz Kassai, Justine Bacchetta
OBJECTIVE: Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. METHODS: This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the ultra-distal tibia...
June 5, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Ying He, Tomasz Kosciolek, Jinsong Tang, Yao Zhou, Zongchang Li, Xiaoqian Ma, Qiyun Zhu, Ning Yuan, Liu Yuan, Chunwang Li, Ke Jin, Rob Knight, Ming T Tsuang, Xiaogang Chen
BACKGROUND: The microbiota-gut-brain axis and membrane dysfunction in the brain has attracted increasing attention in the field of psychiatric research. However, the possible interactive role of gut microbiota and brain function in the prodromal stage of schizophrenia has not been studied yet. METHODS: To explore this, we collected fecal samples and performed Magnetic Resonance Spectroscopy (MRS) scans in 81 high risk (HR) subjects, 19 ultra-high risk (UHR) subjects and 69 health controls (HC)...
June 2, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
Vlatka Boričević Maršanić, Josipa Jukić, Mia Flander
The onset of psychosis is typically preceded by a prodromal phase that is characterised by the emergence of "attenuated" psychotic symptoms. This phase is described as ultra-high risk (UHR) or at-risk mental state (ARMS) of psychosis. Criteria have been established for identifying these young people who are at clinical high risk. People at ultra-high risk (UHR) of psychosis have about 30% chance of developing the illness within two years. This category was introduced with the goal of developing treatments for prevention of psychotic disorders...
June 2018: Psychiatria Danubina
Vinita Jagannath, Miriam Gerstenberg, Susanne Walitza, Maurizia Franscini, Karsten Heekeren, Wulf Rössler, Anastasia Theodoridou, Edna Grünblatt
Little is known about valid predictive markers for functional outcomes in an at-risk for psychosis population. In a cohort of 185 individuals (age: 13-35 years) at high risk (HR) and ultra-high risk (UHR), we assessed pan-NRG1 mRNA levels across good functional status (GFS) and poor functional status (PFS) at baseline, and good functional outcome (GFO) and poor functional outcome (PFO) at 12-month follow-up. NRG1 mRNA levels were significantly higher in individuals with PFO than individuals with GFO at 12-month follow-up...
May 17, 2018: Psychiatry Research
Jessica A Hartmann, Barnaby Nelson, Aswin Ratheesh, Devi Treen, Patrick D McGorry
Identifying young people at risk of developing serious mental illness and identifying predictors of onset of illness has been a focus of psychiatric prediction research, particularly in the field of psychosis. Work in this area has facilitated the adoption of the clinical staging model of early clinical phenotypes, ranging from at-risk mental states to chronic and severe mental illness. It has been a topic of debate if these staging models should be conceptualised as disorder-specific or transdiagnostic. In order to inform this debate and facilitate cross-diagnostic discourse, the present scoping review provides a broad overview of the body of literature of (a) longitudinal at-risk approaches and (b) identified antecedents of (homotypic) illness progression across three major mental disorders [psychosis, bipolar disorder (BD) and depression], and places these in the context of clinical staging...
June 4, 2018: Psychological Medicine
G Fond, O Godin, L Boyer, F Berna, M Andrianarisoa, N Coulon, L Brunel, E Bulzacka, B Aouizerate, D Capdevielle, I Chereau, T D'Amato, C Dubertret, J Dubreucq, C Faget, S Leignier, C Lançon, J Mallet, D Misdrahi, C Passerieux, R Rey, A Schandrin, M Urbach, P Vidailhet, P M Llorca, F Schürhoff, M Leboyer
A high rate of patients with schizophrenia (SZ) does not sufficiently respond to antipsychotic medication, which is associated with relapses and poor outcomes. Chronic peripheral inflammation has been repeatedly associated with schizophrenia risk and particularly to poor responders to treatment as usual with cognitive impairment in SZ subjects. The objective of present study was to confirm if ultra resistance to treatment in schizophrenia (UTRS) was associated to chronic peripheral inflammation in a non-selected sample of community-dwelling outpatients with schizophrenia...
May 28, 2018: European Archives of Psychiatry and Clinical Neuroscience
Andrea Raballo, Elena Monducci, Mauro Ferrara, Paolo Fiori Nastro, Claudia Dario
Trait-like anomalies of subjective experience (aka, Basic Self-disturbance or Self-disorder, SD) have been empirically identified as schizophrenia-specific markers of vulnerability in several clinical and genetic high-risk populations. However, such specificity is still to be tested in developmental years, where emerging psychopathology is less crystallized and diagnostic boundaries more blurred. Thus, the current study explores the distribution of SD in adolescent help-seekers (age range 14 to 18) and tests the specificity of SD with respect to the severity of their diagnostic staging (Early Onset schizophrenia-spectrum psychosis [EOP], ultra high-risk [UHR] and clinical help-seeking controls [CHSC])...
May 24, 2018: Schizophrenia Research
Zixu Yang, Keane Lim, Max Lam, Richard Keefe, Jimmy Lee
INTRODUCTION: The Positive and Negative Syndrome Scale (PANSS), a comprehensive psychopathology assessment scale used in the evaluation of psychopathology in schizophrenia, is also often used in the Ultra-High-Risk (UHR) population. This paper examined the dimensional structure of the PANSS in a UHR sample. METHODS: A total of 168 individuals assessed to be at UHR for psychosis on the Comprehensive Assessment of At-Risk Mental States (CAARMS) were evaluated on the PANSS, Calgary Depression Scale for Schizophrenia (CDSS), Beck Anxiety Inventory (BAI), Brief Assessment of Cognition in Schizophrenia (BACS), and Global Assessment of Functioning (GAF)...
May 24, 2018: Schizophrenia Research
Xiangsheng Zhao, Yan Mu, Meihua Yang
Plant growth retardants may play an important role in regulation of yield and quality of crops, fruits, and vegetables. Such compounds have begun to be used in the cultivation of traditional Chinese medicines (TCMs), especially for root medicines. Although the potential risks to human health of these compounds has attracted increasing attention, analytical methods for detection of plant growth retardants in TCMs remain poorly investigated. In this study, an effective and reliable method for simultaneous determination of 11 plant growth retardants in Ophiopogon japonicus and soil samples was developed by ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometry (UPLC-QqQ-MS/MS)...
May 18, 2018: Chemosphere
Alberto Oldani, Marcello Calabrò, Fabio Maroso, Giacomo Deiro, Lidia Ravizzini, Valentina Gentile, Chiara Magaton, Maurizio Amato, Sergio Gentilli
BACKGROUND: Acute calculous cholecystitis is a leading cause for hospital admission especially in developed countries. As older age population increases, medical research should consider the efficacy of all therapeutic options, including early surgical procedure in an emergency context, for the treatment of acute cholecystitis in elderly high risk patients. METHODS: From 01/01/2012 to 31/12/2016, 245 patients were admitted to our Institution with diagnosis of acute cholecystitis and managed with cholecistectomy within the same hospitalization...
May 24, 2018: Minerva Chirurgica
Parvin Eslami Shahrbabki, Bahador Hajimohammadi, Shahram Shoeibi, Mehdi Elmi, Arash Yousefzadeh, Gea Oliveri Conti, Margherita Ferrante, Maryam Amirahmadi, Yadolah Fakhri, Amin Mousavi Khaneghah
A modified "Quick, Easy, Cheap, Effective, Rugged, and Safe" QuEChERS in combination with Ultra-High Performance Liquid Chromatography/tandem mass spectrometry (UHPLC-MS/MS) method was optimized for the determination of acrylamide content in different types of tah-dig (rice, bread, and potato). Also, the non-carcinogenic and carcinogenic risks (target hazard quotient (THQ) and incremental lifetime cancer risk (ILCR)) due to ingestion of acrylamide via tah-dig in the adults and children were assessed by Monte Carlo simulation (MCS) method...
May 21, 2018: Food and Chemical Toxicology
Xu Zhu, Xinlin Li, Ti Zhang, Limei Zhao
The present study was aimed at identifying genetic and non-genetic risk factors for valproic acid (VPA)-induced hyperammonaemia in Chinese paediatric patients with epilepsy. A total of 210 epileptic patients, treated with VPA as monotherapy, were enrolled and classified into hyperammonaemia and control groups according to their blood ammonia level (cut-off value 50 μmol/L). Serum concentrations of VPA and its major metabolites were simultaneously determined by ultra-high performance liquid chromatography-tandem mass spectrometry...
May 23, 2018: Basic & Clinical Pharmacology & Toxicology
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