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https://www.readbyqxmd.com/read/28087371/use-of-the-heart-pathway-with-high-sensitivity-cardiac-troponins-a-secondary-analysis
#1
Simon A Mahler, Jason P Stopyra, Fred S Apple, Robert F Riley, Gregory B Russell, Brian C Hiestand, James W Hoekstra, Cedric W Lefebvre, Bret A Nicks, David M Cline, Kim L Askew, David M Herrington, Gregory L Burke, Chadwick D Miller
OBJECTIVES: The HEART Pathway combines a decision aid and serial contemporary cardiac troponin I (cTnI) measures to achieve >99% sensitivity for major adverse cardiac events (MACE) at 30days and early discharge rates >20%. However, the impact of integrating high-sensitivity troponin (hs-cTn) measures into the HEART Pathway has yet to be determined. In this analysis we compare test characteristics of the HEART Pathway using hs-cTnI, hs-cTnT, or cTnI. DESIGN &METHODS: A secondary analysis of participants enrolled in the HEART Pathway RCT was conducted...
January 10, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28079061/progressive-decline-in-hippocampal-ca1-volume-in-individuals-at-ultra-high-risk-for-psychosis-who-do-not-remit-findings-from-the-longitudinal-youth-at-risk-study
#2
New Fei Ho, Daphne J Holt, Mike Cheung, Juan Eugenio Iglesias, Alex Goh, Mingyuan Wang, Joseph Kw Lim, Joshua de Souza, Joann S Poh, Yuen Mei See, Alison R Adcock, Stephen J Wood, Michael Wl Chee, Jimmy Lee, Juan Zhou
Most individuals identified as ultra high-risk for psychosis (UHR) do not develop frank psychosis. They continue to exhibit subthreshold symptoms, or go on to fully remit. Prior work has shown that the volume of CA1, a subfield of the hippocampus, is selectively reduced in the early stages of schizophrenia. Here, we aimed to determine whether patterns of volume change of CA1 are different in UHR individuals who do or do not achieve symptomatic remission. Structural MRI scans were acquired at baseline and at 1-2 follow-up time points (at 12-month intervals) from 147 UHR and healthy control subjects...
January 12, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28074977/-association-of-c-reactive-protein-levels-with-metabolic-syndrome-in-adults-a-population-based-study
#3
Patricia Bustos, Bernardita Rosas, Pablo Román, Juan Villagrán, Hugo Amigo
BACKGROUND: Metabolic syndrome is highly prevalent among adults in Chile and represents a health risk. AIM: To determine the relationship between metabolic syndrome (MetS) and its components, with C reactive protein levels (CRP) as an inflammation marker. MATERIAL AND METHODS: The population studied consisted of 736 individuals born in a hospital from Valparaíso Region, aged between 32-38 years at the time of the study. MetS was identified according to the Adult Treatment Panel (ATP) III guidelines and inflammation was measured using ultra-sensitive CRP...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28068468/aggregation-kinetics-and-self-assembly-mechanisms-of-graphene-quantum-dots-in-aqueous-solutions-cooperative-effects-of-ph-and-electrolytes
#4
Qingqing Li, Baoliang Chen, Baoshan Xing
The cooperative effects of pH and electrolytes on the aggregation of GQDs and the aggregate morphologies are characterized. Because GQDs have an average size of 9 nm with abundant O-functionalized edges, their suspension was very stable even in a high electrolyte concentration and low pH solution. Divalent cations (Mg2+ and Ca2+) exceled at aggregating the GQD nanoplates, while monovalent cations (Na+ and K+) did not disturb the stability. For Na+ and K+, positive linear correlations were observed between the critical coagulation concentration (CCC) and pH levels...
January 9, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28058584/pyrethroid-insecticide-lambda-cyhalothrin-and-its-metabolites-induce-liver-injury-through-the-activation-of-oxidative-stress-and-proinflammatory-gene-expression-in-rats-following-acute-and-subchronic-exposure
#5
Bakhta Aouey, Mohamed Derbali, Yassine Chtourou, Michèle Bouchard, Abdelmajid Khabir, Hamadi Fetoui
Lambda-cyhalothrin (LTC) [α-cyano-3-phenoxybenzyl-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclo-propanecarboxylate] is a synthetic type II pyrethroid insecticide commonly used in residential and agricultural areas. The potential hepatotoxicity of pyrethroids remains unclear and could easily be assessed by measuring common clinical indicators of liver disease. To understand more about the potential risks for humans associated with LTC exposure, male adult rats were orally exposed to 6.2 and 31.1 mg/kg bw of LTC for 7, 30, 45, and 60 days...
January 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28054132/course-of-clinical-high-risk-states-for-psychosis-beyond-conversion
#6
Chantal Michel, Stephan Ruhrmann, Benno G Schimmelmann, Joachim Klosterkötter, Frauke Schultze-Lutter
BACKGROUND: The main focus of research on clinical high-risk states for psychosis (CHR) has been the development of algorithms to predict psychosis. Consequently, other outcomes have been neglected, and little is known about the long-term diagnostic and functional outcome among those not converting to psychosis. METHODS: In a naturalistic study, incidence, persistence, and remission rates of CHR states according to symptomatic ultra-high risk or cognitive disturbances criteria were investigated in 160 of 246 outpatients of an early detection of psychoses service (21...
January 4, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28053130/diagnostic-and-prognostic-significance-of-brief-limited-intermittent-psychotic-symptoms-blips-in-individuals-at-ultra-high-risk
#7
Paolo Fusar-Poli, Marco Cappucciati, Andrea De Micheli, Grazia Rutigliano, Ilaria Bonoldi, Stefania Tognin, Valentina Ramella-Cravaro, Augusto Castagnini, Philip McGuire
BACKGROUND: Brief Limited Intermittent Psychotic Symptoms (BLIPS) are key inclusion criteria to define individuals at ultra high risk for psychosis (UHR). Their diagnostic and prognostic significance is unclear. OBJECTIVES: To address the baseline diagnostic relationship between BLIPS and the ICD-10 categories and examine the longitudinal prognostic impact of clinical and sociodemographic factors. METHODS: Prospective long-term study in UHR individuals meeting BLIPS criteria...
January 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28052273/current-status-of-exposed-endoscopic-full-thickness-resection-and-further-development-of-non-exposed-endoscopic-full-thickness-resection
#8
Hirohito Mori, Asadur Rahman, Hideki Kobara, Shintaro Fujihara, Noriko Nishiyama, Maki Ayaki, Tae Matsunaga, Masanori Murakami, Tsumomu Masaki
Endoscopic full-thickness resection (EFTR) is a procedure that makes it possible to access the lesions that are on the wall of the digestive tract via the shortest distance through the mouth. Because of the ultra-minimal invasive nature of the treatment, pure EFTR is a highly promising surgical procedure that allows the radical excision of full-thickness layers of digestive tract tumors using only a flexible endoscope. There are 2 types of EFTR methods: exposed and non-exposed. Considering the risks of contracting infection and intraperitoneal dissemination of tumor cells, non-exposed EFTR is an ideal method...
2017: Digestion
https://www.readbyqxmd.com/read/28043083/lung-ultrasound-in-the-management-of-fluid-volume-in-dialysis-patients-potential-usefulness
#9
EDITORIAL
Carmine Zoccali
Volume overload is a hidden, pervasive complication in dialysis patients with dyspnea and pulmonary edema being its main clinical manifestations. Measuring lung water has clinical potential because it allows timely treatment of lung congestion at a preclinical stage. Chest ultrasound (US) is a novel, well-validated technique that allows reliable estimates of lung water in clinical practice. The application of this technique in dialysis patients has shown that an unsuspectedly high proportion of these patients have moderate to severe lung congestion which is usually asymptomatic...
January 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28028300/high-quality-cell-block-preparation-from-scraping-of-conventional-cytology-slide-a-technical-report-on-a-modified-cytoscrape-cell-block-technique
#10
Y I Choi, M Jakhongir, S J Choi, L Kim, I S Park, J Y Han, J M Kim, Y C Chu
BACKGROUND: Immunocytochemistry (ICC) on formalin-fixed paraffin embedded cell blocks is an ancillary tool commonly recruited for differential diagnoses of fine needle aspiration cytology (FNAC) samples. However, the quality of conventional cell blocks in terms of adequate cellularity and evenness of distribution of cytologic material is not always satisfactory for ICC. We introduce a modified agarose-based cytoscrape cell block (CCB) technique that can be effectively used for the preparation of cell blocks from scrapings of conventional FNAC slides...
December 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28025031/triclosan-triclocarban-levels-in-maternal-and-umbilical-blood-samples-and-their-association-with-fetal-malformation
#11
Ling Wei, Pengyun Qiao, Ying Shi, Yan Ruan, Jie Yin, Qingqing Wu, Bing Shao
Triclosan (TCS) and triclocarban (TCC) are widely used as antimicrobial compounds in consumer products. TCS and TCC are frequently found in waste water and sewage. In this study, we investigate the potential impact of exposure to triclosan (TCS) and triclocarban (TCC) on fetal abnormalities. We measured TCS and TCC levels in maternal and umbilical cord blood samples from 39 pregnant women diagnosed with fetal or post-birth abnormalities at Beijing Obstetrics and Gynecology Hospital. 52 pregnant women who gave birth to healthy neonates during the same period of time were included as controls...
December 23, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28018980/the-londowns-adult-cognitive-assessment-to-study-cognitive-abilities-and-decline-in-down-syndrome
#12
Carla M Startin, Sarah Hamburg, Rosalyn Hithersay, Amy Davies, Erin Rodger, Nidhi Aggarwal, Tamara Al-Janabi, André Strydom
BACKGROUND: Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with an ultra-high risk of developing Alzheimer's disease. However, there is individual variability in the onset of clinical dementia and in baseline cognitive abilities prior to decline, particularly in memory, executive functioning, and motor coordination. The LonDownS Consortium aims to determine risk and protective factors for the development of dementia and factors relating to cognitive abilities in people with DS...
November 15, 2016: Wellcome Open Res
https://www.readbyqxmd.com/read/28009047/longitudinal-monitoring-of-gene-expression-in-ultra-low-volume-blood-samples-self-collected-at-home
#13
Cate Speake, Elizabeth Whalen, Vivian H Gersuk, Damien Chaussabel, Jared M Odegard, Carla J Greenbaum
Blood transcriptional profiles could serve as biomarkers of clinical changes in subjects at-risk for or diagnosed with diabetes. However, transcriptional variation over time is poorly understood due to the impracticality of frequent longitudinal phlebotomy in large patient cohorts. We have developed a novel transcriptome assessment method that could be applied to fingerstick blood samples self-collected by study volunteers. 15 μL of blood from a fingerstick yielded sufficient RNA to analyze >176 transcripts by high-throughput quantitative PCR...
December 23, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28002511/the-prognostic-and-clinical-significance-of-neuroimagistic-and-neurobiological-vulnerability-markers-in-correlation-with-the-molecular-pharmacogenetic-testing-in-psychoses-and-ultra-high-risk-categories
#14
Laura Alexandra Nussbaum, Lavinia Maria Hogea, Nicoleta Ioana Andreescu, Raluca Claudia Grădinaru, Maria Puiu, Andrei Todica
We approach an integrated, multidisciplinary, innovative research-action model in children and adolescents with psychosis and ultra high-risk categories. Our main focus was: to investigate the prognostic and clinical significance of neuroimagistic and neurobiological vulnerability markers in correlation with the molecular pharmacogenetic testing in psychoses and ultra high-risk categories; the dynamic evaluation of the clinical evolution for the studied groups in correlation with specific neurobiological and neuroimagistic variables and markers...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27998657/the-relationship-between-polyethylene-wear-and-periprosthetic-osteolysis-in-total-hip-arthroplasty-at-12-years-in-a-randomized-controlled-trial-cohort
#15
John A J Broomfield, Tamer T Malak, Geraint E R Thomas, Antony J R Palmer, Adrian Taylor, Sion Glyn-Jones
BACKGROUND: Polyethylene acetabular components are common in hip arthroplasty. Highly cross-linked polyethylene (HXLPE) has lower wear than ultra-high molecular weight polyethylene (UHMWPE). Evidence suggests that wear particles induce inflammation causing periprosthetic osteolysis contributing to implant loosening with wear rates of 0.05 mm/y were considered safe. We aimed to compare incidence and volume of periacetabular osteolysis between HXLPE and UHMWPE using computed tomography...
November 8, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27996252/the-formation-and-occurrence-of-n-chloro-2-2-dichloroacetamide-a-previously-overlooked-nitrogenous-disinfection-byproduct-in-chlorinated-drinking-waters
#16
Yun Yu, David A Reckhow
Haloacetamides (HAMs) are a class of newly identified nitrogenous disinfection byproducts (N-DBPs) whose occurrence in drinking waters has recently been reported in several DBP surveys. As the most prominent HAM species, it is commonly acknowledged that 2,2-dichloroacetamide (DCAM) is mainly generated from dichloroacetonitrile (DCAN) hydrolysis because the concentrations of these two compounds are often well correlated. Instead of DCAM, a previously unreported N-DBP, N-chloro-2,2-dichloroacetamide (N-Cl-DCAM), was confirmed in this study as the actual DCAN degradation product in chlorinated drinking waters...
December 20, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27992836/deconstructing-vulnerability-for-psychosis-meta-analysis-of-environmental-risk-factors-for-psychosis-in-subjects-at-ultra-high-risk
#17
P Fusar-Poli, M Tantardini, S De Simone, V Ramella-Cravaro, D Oliver, J Kingdon, M Kotlicka-Antczak, L Valmaggia, J Lee, M J Millan, S Galderisi, U Balottin, V Ricca, P McGuire
BACKGROUND: Subjects at ultra high-risk (UHR) for psychosis have an enhanced vulnerability to develop the disorder but the risk factors accounting for this accrued risk are undetermined. METHOD: Systematic review of associations between genetic or environmental risk factors for psychosis that are widely established in the literature and UHR state, based on comparisons to controls. RESULTS: Forty-four studies encompassing 170 independent datasets and 54 risk factors were included...
December 16, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27988079/urinary-metabolomics-revealed-arsenic-exposure-related-to-metabolic-alterations-in-general-chinese-pregnant-women
#18
Han Li, Mu Wang, Qiande Liang, Shuna Jin, Xiaojie Sun, Yangqian Jiang, Xingyun Pan, Yanqiu Zhou, Yang Peng, Bin Zhang, Aifen Zhou, Yiming Zhang, Zhong Chen, Jiangxia Cao, Hongling Zhang, Wei Xia, Tongzhang Zheng, Zongwei Cai, Yuanyuan Li, Shunqing Xu
Arsenic exposure is considered a major environmental threat to human health. It is already known that high-level arsenic exposure has adverse effects on human health. Since the pregnant women are known to be more susceptible to some chemical exposures than ordinary people, the understanding regarding the health effects of low-level arsenic exposure on pregnant women is critical and remains unclear. The aim of this study is to investigate the urinary metabolic changes of pregnant women exposed to low-dose arsenic, and to identify biomarkers from metabolomics analysis...
January 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27987484/social-relationships-in-young-adults-at-ultra-high-risk-for-psychosis
#19
Briana L Robustelli, Raeana E Newberry, Mark A Whisman, Vijay A Mittal
Studies suggest that individuals with schizophrenia have smaller social networks and less satisfying relationships. However, much is still unknown about the typical quantity and quality of social relationships in young adults during the ultra high-risk (UHR) period. Investigating these relationships holds significant importance for improving understanding of etiological processes, mapping the social environment, and highlighting treatment targets in a critical period. A total of 85 participants (44 UHR and 41 healthy controls) completed measures examining the participants' social relationships, social support, and loneliness...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27986507/effects-of-iterative-reconstruction-algorithms-on-computer-assisted-detection-cad-software-for-lung-nodules-in-ultra-low-dose-ct-for-lung-cancer-screening
#20
Yukihiro Nomura, Toru Higaki, Masayo Fujita, Soichiro Miki, Yoshikazu Awaya, Toshio Nakanishi, Takeharu Yoshikawa, Naoto Hayashi, Kazuo Awai
RATIONALE AND OBJECTIVES: This study aimed to evaluate the effects of iterative reconstruction (IR) algorithms on computer-assisted detection (CAD) software for lung nodules in ultra-low-dose computed tomography (ULD-CT) for lung cancer screening. MATERIALS AND METHODS: We selected 85 subjects who underwent both a low-dose CT (LD-CT) scan and an additional ULD-CT scan in our lung cancer screening program for high-risk populations. The LD-CT scans were reconstructed with filtered back projection (FBP; LD-FBP)...
December 13, 2016: Academic Radiology
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