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https://www.readbyqxmd.com/read/29438680/ischemia-reperfusion-injury-alters-skin-microvascular-responses-to-local-heating-of-the-index-finger
#1
Gregory W McGarr, Gary J Hodges, Matthew M Mallette, Stephen S Cheung
BACKGROUND: Ischemia-reperfusion (IR) injury impairs microcirculatory function by reducing nitric oxide (NO) bioavailability and increasing sympathetic tone. This study non-invasively examined the effects of acute upper limb IR injury on local thermal hyperemia (LTH) in glabrous and non-glabrous finger skin. MATERIALS AND METHODS: In ten healthy males, LTH was examined twice (~7-10 d apart) for each skin type on the index finger using laser-Doppler flowmetry in a counterbalanced design with either 1) 20 min ischemia, followed by reperfusion (ISCH) or 2) time-matched control (SHAM)...
February 10, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29438648/managing-menopausal-symptoms-after-cancer-an-evidence-based-approach-for-primary-care
#2
Jennifer L Marino, Helen C McNamara, Martha Hickey
Impaired ovarian function and menopausal symptoms are common after cancer treatment. Menopausal symptoms often occur at an earlier age in women with cancer, and may be more severe than in natural menopause; they may be the most persistent and troubling sequelae of cancer. A third of female patients with cancer report dissatisfaction with the quality and length of physician-patient discussions about reproductive health, including menopause. Systemic menopausal hormone therapy is the most effective treatment for menopausal symptoms, but it is not suitable for all patients after cancer - where it is unsuitable, alternative effective non-hormonal treatments are available...
February 19, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29436000/bascule-syndrome-associated-with-syncopal-episodes
#3
José M Martín, Catalina Torres, Pilar Cordero, Sara Sánchez, Liria Terradez, Dolores Ramón
Bascule syndrome is a recently described benign vasomotor dermatosis characterized by Bier anemic spots, cyanosis, and urticaria-like eruption. We report a case of a 13-year-old girl with cutaneous lesions consistent with Bascule syndrome who had had three exercise-related syncopal episodes. It would be recommended to exclude orthostatic intolerance or postural orthostatic tachycardia syndrome when evaluating patients with Bascule syndrome.
February 13, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29431408/transdermal-estrogen-and-progestogen-most-effective-to-reduce-menopausal-vasomotor-symptoms
#4
Linda Speer
No abstract text is available yet for this article.
December 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29429422/the-role-of-sleep-difficulties-in-the-vasomotor-menopausal-symptoms-and-depressed-mood-relationships-an-international-pooled-analysis-of-eight-studies-in-the-interlace-consortium
#5
Hsin-Fang Chung, Nirmala Pandeya, Annette J Dobson, Diana Kuh, Eric J Brunner, Sybil L Crawford, Nancy E Avis, Ellen B Gold, Ellen S Mitchell, Nancy F Woods, Joyce T Bromberger, Rebecca C Thurston, Hadine Joffe, Toyoko Yoshizawa, Debra Anderson, Gita D Mishra
BACKGROUND: Many women experience both vasomotor menopausal symptoms (VMS) and depressed mood at midlife, but little is known regarding the prospective bi-directional relationships between VMS and depressed mood and the role of sleep difficulties in both directions. METHODS: A pooled analysis was conducted using data from 21 312 women (median: 50 years, interquartile range 49-51) in eight studies from the InterLACE consortium. The degree of VMS, sleep difficulties, and depressed mood was self-reported and categorised as never, rarely, sometimes, and often (if reporting frequency) or never, mild, moderate, and severe (if reporting severity)...
February 12, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29427202/predictors-of-vasomotor-symptoms-among-breast-cancer-survivors
#6
Katherine W Reeves, Michael Pennell, Randi E Foraker, Carolyn J Crandall, Marcia Stefanick, Electra D Paskett
PURPOSE: Vasomotor symptoms (VMS) are a common side effect of breast cancer treatment, yet modifiable factors that may predict VMS among breast cancer survivors are unknown. METHODS: We estimated multivariable-adjusted odds ratios and 95% confidence intervals (aOR, 95% CI) for predictors of VMS among 3595 breast cancer survivors enrolled in the Life and Longevity after Cancer (LILAC) study, an ancillary study of the Women's Health Initiative (WHI). RESULTS: VMS post-diagnosis were reported by 790 (22...
February 9, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29409933/signs-and-symptoms-in-1043-patients-with-complex-regional-pain-syndrome-crps
#7
Stephan Ott, Christian Maihöfner
Complex regional pain syndrome (CRPS) is a complex pain disorder that can emerge after limb trauma or a lesion in the peripheral nervous system. Typical features include continuing pain, sensory, vasomotor, sudomotor, motor and trophic changes as well as edema. These signs provide the basis of CRPS diagnosis. A detailed description of the signs, symptoms and medical history of CRPS could potentially facilitate an earlier and more accurate diagnosis. The aim of this study is to provide such a description, based on epidemiological measures, clinical presentation and a thorough description of pain sensations...
February 1, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29407125/the-emergence-of-the-coronary-vasomotor-dysfunction-era
#8
EDITORIAL
John F Beltrame
No abstract text is available yet for this article.
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29407000/the-arteriolar-injury-in-hypertension
#9
Qian Ru Gu, Yang Yang Li, Guo Rong Chen, M J Quinn
In 1937, Drs. Moritz and Oldt described arteriolar injuries in the kidneys (and other viscera) in hypertension, across the age range, in both sexes, and, in different races. This hypothesis proposes that injuries to vasomotor nerves cause the arteriolar injury in the kidney in hypertension, (as well as that in the uterus in preeclampsia). Different patterns of perivascular hyalinisation in different viscera are clues to the varying causes and consequences of arteriolar injury. In the uterus there is a symmetrical, perivascular "halo of hyalinisation" that marks the lines of extension of regenerating, injured nerves to the placental bed, whereas in the kidney there is a disordered and asymmetrical "halo of hyalinisation" where persistent, and recurrent, increases in intravascular pressures interrupt development of regenerating nerves...
February 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29406914/cerebral-vasoreactivity-and-intima-media-thickness-in-down-syndrome-a-case-control-study
#10
M Colella, C Stilo, A Cocchella, D Bianchini, A Pilotto, P Del Sette, R Musolino
Subjects with Down Syndrome (DS) have high prevalence of cerebral vascular amyloidosis, cognitive decline and dementia. In Alzheimer Disease, impaired vasoreactivity has been reported as the results of vascular amyloid deposition. Aim of our study was to verify presence of impaired cerebral vasoreactivity and to study carotid intima media-thickness (IMT) by carotid and transcranial ultrasound. We studied 25 DS and compared them with 25 age- and sex-matched normal controls. Vasomotor reactivity was evaluated by means of breath-holding index (BHI) test...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29406426/history-of-vasomotor-symptoms-extent-of-coronary-artery-disease-and-clinical-outcomes-after-acute-coronary-syndrome-in-postmenopausal-women
#11
Luca A Ferri, Nuccia Morici, Giorgio Bassanelli, Nicoletta Franco, Leonardo Misuraca, Laura Lenatti, Emilia Lo Jacono, Chiara Leuzzi, Elena Corrada, Tiziana C Aranzulla, Delia Colombo, Angelo Cagnacci, Francesco Prati, Stefano Savonitto
OBJECTIVE: Vasomotor symptoms (VMS) during menopausal transition have been linked to a higher burden of cardiovascular risk factors, subclinical vascular disease, and subsequent vascular events. We aim to investigate the association of VMS with the extent of coronary disease and their prognostic role after an acute coronary syndrome. METHODS: The Ladies Acute Coronary Syndrome study enrolled consecutive women with an acute coronary syndrome undergoing coronary angiography...
February 5, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29405505/sympathetic-vasomotor-activity-during-dynamic-exercise-with-resistive-breathing-sex-differences-and-the-nerve-to-show-it
#12
Ken D O'Halloran
Respiratory muscle metaboreflexes exert substantial influence over cardiorespiratory and autonomic control, exemplified during heavy dynamic exercise in health, and in obstructive airways disease even at rest. This article is protected by copyright. All rights reserved.
February 5, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29404595/should-this-patient-receive-hormone-therapy-for-her-menopausal-symptoms-grand-rounds-discussion-from-beth-israel-deaconess-medical-center
#13
Eileen E Reynolds, Carol Bates, Martha Richardson, Risa B Burns
Hormone therapy (HT) was widely prescribed in the 1980s and 1990s and has been controversial since the initial results of the Women's Health Initiative (WHI) trial in the early 2000s suggested that it increased risk for breast cancer and coronary heart disease and did not prolong life. However, more recent data and reexamination of the WHI results suggest that HT is safe and effective for many women when used around the time of menopause. Two experts debate the 2017 Hormone Therapy Position Statement of The North American Menopause Society, which recommends HT as first-line treatment of vasomotor symptoms, and apply it to the care of Ms...
February 6, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29401137/differential-effects-of-selective-and-nonselective-potassium-channel-inhibitors-in-ovine-endotoxemic-shock-macrocirculation-and-in-a-rat-model-of-septic-shock-microcirculation
#14
Michael Hessler, Bernardo B Pinto, Philip-Helge Arnemann, Tim-Gerald Kampmeier, Laura Seidel, Andrea Morelli, Hugo Van Aken, Martin Westphal, Sebastian Rehberg, Christian Ertmer
BACKGROUND: Potassium-(K)-channel inhibitors may increase systemic vascular resistance in vasodilatory shock states. OBJECTIVE: The purpose of the present study was to compare the macro- and microvascular effects of the adenosine triphosphate-sensitive K-channel-(KATP)-inhibitor glipizide and the nonselective K-channel inhibitor tetraethylammonium (TEA) in ovine endotoxemic shock and septic shock in rats. DESIGN: Two randomized, controlled laboratory studies...
February 2, 2018: Shock
https://www.readbyqxmd.com/read/29396368/liver-specific-rescuing-of-ceacam1-reverses-endothelial-and-cardiovascular-abnormalities-in-male-mice-with-null-deletion-of-ceacam1-gene
#15
Lucia Russo, Harrison T Muturi, Hilda E Ghadieh, Alexander M Wisniewski, Eric E Morgan, Syed S Quadri, Gavin P Landesberg, Helmy M Siragy, Guillermo Vazquez, Rosario Scalia, Rajesh Gupta, Sonia M Najjar
OBJECTIVE: Mice with global null mutation of Ceacam1 (Cc1-/-), display impairment of insulin clearance that causes hyperinsulinemia followed by insulin resistance, elevated hepatic de novo lipogenesis, and visceral obesity. In addition, they manifest abnormal vascular permeability and elevated blood pressure. Liver-specific rescuing of Ceacam1 reversed all of the metabolic abnormalities in Cc1-/-liver+ mice. The current study examined whether Cc1-/- male mice develop endothelial and cardiac dysfunction and whether this relates to the metabolic abnormalities caused by defective insulin extraction...
January 26, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29394279/characterisation-of-the-vasodilation-effects-of-dha-and-epa-n-3-pufas-fish-oils-in-rat-aorta-and-mesenteric-resistance-arteries
#16
Roshan Limbu, Graeme S Cottrell, Alister J McNeish
BACKGROUND AND PURPOSE: Increasing evidence suggests that the omega-3 polyunsaturated acids (n-3 PUFA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are beneficial to cardiovascular health, promoting relaxation of vascular smooth muscle cells and vasodilation. Numerous studies have attempted to study these responses, but to date there has not been a systematic characterisation of both DHA and EPA mediated vasodilation in conduit and resistance arteries. Therefore, we aimed to fully characterise the n-3 PUFA-induced vasodilation pathways in rat aorta and mesenteric artery...
2018: PloS One
https://www.readbyqxmd.com/read/29393689/zolpidem-efficacy-and-safety-in-disorders-of-consciousness
#17
Calixto Machado, Mario Estévez, Rafael Rodriguez-Rojas
Sutton and Clauss presented a detailed review about the effectiveness of zolpidem, discussing recoveries from brain damage due to strokes, trauma and hypoxia. A significant finding has been the unexpected and paradoxical increment of brain activity in vegetative state/unresponsive wakefulness syndrome (VS/UWS). On the contrary, zolpidem is considered one of the best sleep inducers in normal subjects. We have studied series of VS/UWS cases after zolpidem intake. We have demonstrated EEG activation, increment of BOLD signal in different brain regions, and an autonomic influence, mainly characterized by a vagolytic chronotropic effect without a significant increment of the vasomotor sympathetic tone...
February 2, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29393227/acute-menopausal-symptoms-in-young-cancer-survivors-immediately-following-chemotherapy
#18
Katherine E Cameron, Martha B Kole, Mary D Sammel, Jill P Ginsberg, Yasmin Gosiengfiao, Jennifer E Mersereau, H Irene Su, Clarisa R Gracia
PURPOSE: The aim of this study was to evaluate the prevalence of menopausal symptoms in young cancer survivors immediately following the completion of chemotherapy. METHODS: This prospective cohort study followed 124 young females with a new diagnosis of cancer requiring chemotherapy to assess symptoms of menopause before treatment and immediately following chemotherapy. Symptoms were compared before and after treatment using the McNemar test and between cancer patients and 133 similar-aged healthy controls using Pearson χ2 and Fisher's exact tests...
January 26, 2018: Oncology
https://www.readbyqxmd.com/read/29390899/vasomotor-symptoms-natural-history-physiology-and-links-with-cardiovascular-health
#19
R C Thurston
Vasomotor symptoms (VMS), or hot flushes and night sweats, are the classic symptom of menopause. Recent years have brought key advances in the knowledge about VMS. VMS last longer than previously thought, on average 7-10 years for frequent or moderate to severe VMS. Although VMS have long been understood to be important to women's quality of life, research has also linked VMS to indicators of cardiovascular disease (CVD) risk, such as an adverse CVD risk factor profile, greater subclinical CVD and, in emerging work, CVD events...
February 2, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29381665/what-s-in-a-name-are-menopausal-hot-flashes-a-symptom-of-menopause-or-a-manifestation-of-neurovascular-dysregulation
#20
Virginia M Miller, Juliana M Kling, Julia A Files, Michael J Joyner, Ekta Kapoor, Ann M Moyer, Walter A Rocca, Stephanie S Faubion
Hot flashes have typically been classified as "symptoms of menopause" that should be tolerated or treated until they resolve. However, mounting evidence points to hot flashes as a manifestation of one or several underlying pathophysiological processes. Associations exist between the presence, timing of onset, severity, and duration of hot flashes, and the risk of several neurological (affecting sleep, mood, and cognition) and cardiovascular conditions. In addition, four consistent patterns of vasomotor disturbances have been identified across different countries, making it unlikely that these patterns are solely explained by socioeconomic or cultural factors...
January 29, 2018: Menopause: the Journal of the North American Menopause Society
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