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Christopher Woodman, John W Seawright, Meredith J Luttrell, Song Yi Shin, Andreea Trache
Current research indicates that vasomotor responses are altered with aging in skeletal muscle resistance arteries. The changes in vasomotor function are characterized by impaired vasodilator and vasoconstrictor responses. The detrimental effects of aging on vasomotor function are attenuated in some vascular beds following a program of endurance exercise training. The signals associated with exercise responsible for inducing improvements in vasomotor function have been proposed to involve short-duration increases in intraluminal shear stress and/or pressure during individual bouts of exercise...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Alynne Carvalho-Galvão, Blessing Ogunlade, Jiaxi Xu, Cristiane R A Silva-Alves, Leônidas G Mendes-Júnior, Drielle D Guimarães, Josiane C Cruz, Thyago M Queiroz, Camille M Balarini, Valdir A Braga, Catalin M Filipeanu, Eric Lazartigues, Maria S França-Silva
TRV027 is a biased agonist for the Angiotensin (Ang)-II type 1 receptor (AT1 R), able to recruit ß-arrestin 2 independently of G-proteins activation. ß-arrestin activation in the central nervous system (CNS) was suggested to oppose the effects of Ang-II. This study evaluates the effect of central infusion of TRV027 on arterial pressure (AP), autonomic function, baroreflex sensitivity and peripheral vascular reactivity. Spontaneously hypertensive (SH) and Wistar Kyoto (WKY) rats were treated with TRV027 for 14 days (20 ng/hour) delivered to the lateral ventricle via osmotic minipumps...
June 14, 2018: Clinical Science (1979-)
Anna Szeliga, Adam Czyzyk, Agnieszka Podfigurna, Andrea R Genazzani, Alessandro D Genazzani, Blazej Meczekalski
Women during perimenopausal period experience a range of symptoms, which interfere with physical, sexual, and social life. About 65-75% of symptoms connected with postmenopausal period are vasomotor symptoms (VMS), such as hot flushes and night sweats. Hot flushes are subjective sensation of heat associated with cutaneous vasodilatation and drop in core temperature. It is suspected that VMS are strongly correlated with pulsatile oversecretion of gonadotropin-releasing hormone (GnRH) and subsequently luteinizing hormone (LH)...
June 14, 2018: Gynecological Endocrinology
Ramesh Chennupati, Merlijn J Meens, Ben J Janssen, Paul van Dijk, Theodorus B M Hakvoort, Wouter H Lamers, Jo G R De Mey, S Eleonore Koehler
Endothelial arginase 1 was ablated to assess whether this prevents hyperglycemia-induced endothelial dysfunction by improving arginine availability for nitric oxide production. Endothelial Arg1-deficient mice (Arg1-KOT ie2 ) were generated by crossing Arg1fl/fl (controls) with Tie2Cretg/- mice and analyzed by immunohistochemistry, measurements of hemodynamics, and wire myography. Ablation was confirmed by immunohistochemistry. Mean arterial blood pressure was similar in conscious male control and Arg1-KOT ie2 mice...
June 2018: Physiological Reports
Rogerio A Lobo, David F Archer, Risa Kagan, Andrew M Kaunitz, Ginger D Constantine, James H Pickar, Shelli Graham, Brian Bernick, Sebastian Mirkin
OBJECTIVE: To evaluate efficacy, endometrial safety, and overall safety of a single-capsule 17β-estradiol-progesterone for treating menopausal moderate-to-severe vasomotor symptoms. METHODS: REPLENISH was a phase 3, 12-month, randomized, double-blind, placebo-controlled, multicenter trial. Women (aged 40-65 years) with vasomotor symptoms and a uterus were randomized to daily estradiol (mg)-progesterone (mg) (1/100, 0.5/100, 0.5/50, or 0.25/50), and women in the vasomotor symptoms substudy (women with moderate-to-severe hot flushes [seven or greater per day or 50 or greater per week]) to those estradiol-progesterone doses or placebo...
June 6, 2018: Obstetrics and Gynecology
Yang Yuan, Mahmoud A Mohammad, Ancizar Betancourt, Inka C Didelija, Chandrasekar Yallampalli, Juan C Marini
Background: The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Pegylated arginine deiminase (ADI-PEG20) is a bacterial enzyme used to deplete circulating arginine. Objective: The goal of this research was to test the hypothesis that citrulline is able to sustain intracellular arginine availability for NO production in ADI-PEG20 arginine-depleted mice...
June 1, 2018: Journal of Nutrition
Stephanie S Faubion, Cynthia A Stuenkel
No abstract text is available yet for this article.
June 4, 2018: Menopause: the Journal of the North American Menopause Society
Cynthia A Stuenkel
Vasomotor symptoms are the most common manifestation of the menopause transition and postmenopausal phases of reproductive life. They interfere not only in quality of life, but also contribute to sleep and mood disturbances that potentially compromise home and work effectiveness. Treatment options include hormone therapy (HT), nonhormonal prescription drugs, mind body and behavior therapies, and over-the-counter preparations. Evidence confirms that HT is the most effective option. The initial reticence to prescribe HT immediately following publication of the Women's Health Initiative has been replaced by clear guidelines for confidently identifying women for whom this therapy will be safe...
May 31, 2018: Clinical Obstetrics and Gynecology
Evelyn M M Wong, George Tomlinson, Marsha M Pinto, Claudie Berger, Angela M Cheung, Jerilynn C Prior
Women's hot flushes and night sweats, collectively called vasomotor symptoms (VMS), are maximal (79%) in late perimenopause. The evidence describing whether VMS are associated with loss of areal bone mineral density (BMD) is mixed. We examined baseline and 2-year data for 1570 randomly selected women aged 43⁻63 in the Canadian Multicentre Osteoporosis Study (CaM os ), a prospective Canada-wide study; we used linear regression to assess the relationship of night sweats (VMSn) with BMD and its changes. Clinically important VMSn occurred for 12...
May 26, 2018: International Journal of Environmental Research and Public Health
Kristin Pogoda, Petra Kameritsch, Hanna Mannell, Ulrich Pohl
Vascular endothelial cells, as well as smooth muscle cells, show heterogeneity with regard to their receptor expression and reactivity. For the vascular wall to act as a functional unit, the various cells' responses require integration. Such an integration is not only required for a homogeneous response of the vascular wall, but also for the vasomotor behaviour of consecutive segments of the microvascular arteriolar tree. Since flow resistances of individual sections are connected in series, sections require synchronization and coordination manner to allow effective changes of conductivity and blood flow...
June 2, 2018: Acta Physiologica
Joann V Pinkerton
The first approved tissue-selective estrogen complex is a pairing of conjugated estrogen combined with the selective estrogen-receptor modulator, bazedoxifene. Advantages include relief of menopausal symptoms without the increased chance of bleeding or breast tenderness unlike with traditional estrogen-progestin therapy, which is associated with both bleeding and breast tenderness. Tissue-selective estrogen complex effects on relief of vasomotor symptoms, prevention of bone loss, improvement in vaginal symptoms, lack of significant cardiovascular effects beyond the expected 2-fold increase in venous thrombosis, neutral effect on breast, and protective effects on the endometrium are discussed...
May 25, 2018: Clinical Obstetrics and Gynecology
Tauqeer Hussain Mallhi, Yusra Habib Khan, Amer Hayat Khan, Qaisar Mahmood, Syed Haroon Khalid, Mohammad Saleem
Hot flushes during menopause are distressing for women and result in poor quality of life. Purpose of the current review was to evaluate the available treatment modalities that should be utilised for the management of hot flushes. Menopause refers to last menses of women life and can be declared after amenorrhea of 12 months. Vasomotor symptoms including hot flushes and night sweats are common after menopause, affecting almost 50 - 85% women older than 45 years. The mean increment in core body and skin temperature is 0...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Thomas Arendt Nielsen, Matilde Alida Eriksen, Parisa Gazerani, Hjalte Holm Andersen
The TRPA1 and TRPV1 receptors are important pharmaceutical targets for antipruritic and analgesic therapy. Obtaining further knowledge on their roles and inter-relationship in humans is therefore crucial. Preclinical results are contradictory concerning co-expression and functional interdependency of TRPV1 and TRPA1 but no human evidence exists. This human experimental study investigated whether functional responses from the subpopulation of TRPA1-nociceptors could be evoked following defunctionalization of TRPV1-nociceptors by cutaneous application of high-concentration capsaicin...
May 25, 2018: Pain
Silvia Lo Vecchio, Hjalte Holm Andersen, Lars Arendt-Nielsen
Topically applied high-concentration capsaicin induces reversible dermo-epidermal denervation and depletion of capsaicin-sensitive nociceptors. This causes desensitization of distinct sensory modalities and is used to treat peripheral neuropathic pain and itch. For high-concentration capsaicin, the selectivity of loss of function and functional recovery rates of various afferent fibers subpopulations are unknown. This study used comprehensive quantitative sensory testing and vasomotor imaging to assess effectiveness, duration and sensory selectivity of high-concentration 8% capsaicin-ablation...
May 29, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Akihiko Yoshimura, Kenjiro Sawada, Tomoyuki Sasano, Hiromasa Kuroda, Katsumi Kozasa, Erika Nakatsuka, Koji Nakamura, Kae Hashimoto, Seiji Mabuchi, Tadashi Kimura
Loss of ovarian function by the treatment for gynecological malignancy results in a drastic decrease of estrogen causing physical and mental symptoms. The purpose of this study is to evaluate the effect of Japanese Kampo Kamikihito (KKT) and Kamishoyosan (KSS) on menopausal symptoms in gynecological cancer patients. Patients who had menopausal symptoms after gynecologic malignancy treatment were enrolled and randomly divided into a KKT or a KSS group. Kupperman Menopausal Index (KI) questionnaires were obtained before tumor treatment, at baseline, and at 4 and 8 weeks...
2018: Obstetrics and Gynecology International
Josep Gomez-Lara, Salvatore Brugaletta, Luis Ortega-Paz, Bert Vandeloo, Elisabetta Moscarella, Miguel Salas, Rafael Romaguera, Gerard Roura, José L Ferreiro, Luis Teruel, Montserrat Gracida, Stephan Windecker, Patrick W Serruys, Joan-Antoni Gomez-Hospital, Manel Sabaté, Angel Cequier
OBJECTIVES: The study sought to compare the vasomotor and microcirculatory function of the infarct-related artery (IRA) between bioresorbable vascular scaffolds (BVS) and everolimus-eluting stents (EES) at 3 years. BACKGROUND: The ABSORB STEMI TROFI II study showed similar outcomes between BVS and EES in the context of ST-segment elevation myocardial infarction at 3 years. METHODS: Sixty-three consecutive event-free patients of the randomized TROFI II study were screened to undergo coronary angiography with vasomotor, microcirculatory, and optical coherence tomography (OCT) examination at 3 years...
May 17, 2018: JACC. Cardiovascular Interventions
Z X Yin, Y Zhu, X Zhai, J L Zhang, G Liu
Objective: To investigate the clinical symptoms and immunology inspection characteristics of nasal cavity local allergy. Method: Selected 60 patients as observation group, who had only nasal local allergy symptoms, allergen skin prick test and serum allergen specific IgE (SIgE) test were negative, 40 allergic rhinitis (AR) patients and 40 healthy volunteers as control groups. To detect Symptom scores and VAS scores, and eosinophilia counts in venous blood, allergen skin prick test (SPT), serum allergen SIgE test, nasal secretions allergen SIgE test, nasal mucous membrane excitation test in both observation group and AR group, eosinophilia counts in nasal secretion, taked the data for statistical analysis...
August 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Q Wu, L Li, J C Shao, D D Zhu
Rhinitis during pregnancy refers to the various causes of rhinitis during the pregnancy, such as allergic rhinitis, vasomotor rhinitis, drug rhinitis, etc. Patients could have symptom before pregnancy, during pregnancy or postpartum symptoms. Pregnancy rhinitis (PR) appear only in pregnancy, and the main clinical manifestations is nasal congestion and the symptom disappeared after pregnancy. There are some similarities between PR and rhinitis during pregnancy, but the clinical feature, treatment option and prognosis are different...
November 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Placido Llaneza, Joaquim Calaf, Ana Rosa Jurado, Nicolas Mendoza, Borja Otero, Francisco Quereda, Rafael Sánchez-Borrego, Daniel Lubian
Tissue-selective estrogen complex (TSEC) is projected as a progestogen-free option for the treatment of estrogen deficiency symptoms in postmenopausal, non-hysterectomized women. TSEC combines the benefits of estrogen with a selective estrogen receptor modulator (SERM), in this case bazedoxifene acetate (BZA), which has an antagonistic effect on the endometrium, thus avoiding the use of progestins. The authorized TSEC combination (conjugated estrogens [CE] 0.45 mg/BZA 20 mg) for the alleviation of vasomotor symptoms has been demonstrated in randomized clinical trials compared with placebo or menopausal hormone therapy (MHT)...
May 23, 2018: Gynecological Endocrinology
Marcelo C Garcia, Elisa H Kozasa, Sergio Tufik, Luiz Eugênio A M Mello, Helena Hachul
OBJECTIVE: The aim of the study was to evaluate the effects of mindfulness and relaxation training for insomnia on insomnia and quality of life in postmenopausal women. METHODS: Thirty postmenopausal women aged 50 to 65 years, who were not using hormone therapy, and had a diagnosis of insomnia and an apnea-hypopnea index of less than 15, were randomly assigned to two groups: a mindfulness intervention group and a control group. They were assessed before the intervention, and 8 weeks after its completion using questionnaires assessing sleep quality (Pittsburgh Sleep Quality Index), insomnia (Insomnia Severity Index), quality of life in menopause (Menopause-Specific Quality of Life), menopausal symptoms (Kupperman Menopausal Index), and level of attention (Mindfulness Awareness Attention Scale)...
May 21, 2018: Menopause: the Journal of the North American Menopause Society
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