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Nitroprusside

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https://www.readbyqxmd.com/read/29773995/hypoxia-reoxygenation-of-rat-renal-arteries-impairs-vasorelaxation-via-modulation-of-endothelium-independent-sgc-cgmp-pkg-signaling
#1
Diana Braun, Christa Zollbrecht, Stefanie Dietze, Rudolf Schubert, Stefan Golz, Holger Summer, Pontus B Persson, Mattias Carlström, Marion Ludwig, Andreas Patzak
Ischemia/reperfusion injury holds a key position in many pathological conditions such as acute kidney injury and in the transition to chronic stages of renal damage. We hypothesized that besides a reported disproportional activation of vasoconstrictor response, hypoxia/reoxygenation (H/R) adversely affects endothelial dilatory systems and impairs relaxation in renal arteries. Rat renal interlobar arteries were studied under isometric conditions. Hypoxia was induced by application of 95% N2 , 5% CO2 for 60 min to the bath solution, followed by a 10 min period of reoxygenation (95% O2 , 5% CO2 )...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29773582/activation-of-large-conductance-calcium-activated-k-channels-by-nitric-oxide-mediates-apelin-induced-relaxation-of-coronary-arteries
#2
Amreen Mughal, Chengwen Sun, Stephen T O'Rourke
Apelin increases coronary blood flow, cardiac contractility and cardiac output. Based on these favorable hemodynamic effects, apelin and apelin-like analogs are being developed for treating heart failure and related disorders; however, the molecular mechanisms underlying apelin-induced coronary vasodilation are unknown. This study aimed to elucidate the signaling pathways by which apelin causes smooth muscle relaxation in coronary arteries. Receptors for apelin (APJ receptors) were expressed in coronary arteries, as determined by Western blot and PCR analyses...
May 17, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29768452/tyrosine-nitration-of-cytosolic-peroxidase-is-probably-triggered-as-a-long-distance-signaling-response-in-sunflower-seedling-cotyledons-subjected-to-salt-stress
#3
Prachi Jain, Satish C Bhatla
Present work focuses on tissue and concentration-dependent effect of nitric oxide (NO) on the modulation of cytosolic peroxidase (POD; EC 1.11.1.7) activity in 2-day old etiolated sunflower (Helianthus annuus L.) seedlings. Exogenously supplied NO (in the form of sodium nitroprusside [SNP] or diethylenetriamine NONOate [DETA]; 125 to 500 μM) results in noteworthy enhancement in seedling growth in a concentration dependent manner irrespective of salt-stress and differentially affects POD activity in 2-day old seedling cotyledons...
2018: PloS One
https://www.readbyqxmd.com/read/29763836/salicylic-acid-and-nitric-oxide-alleviate-high-temperature-induced-oxidative-damage-in-lablab-purpureus-l-plants-by-regulating-bio-physical-processes-and-dna-methylation
#4
Krishna Kumar Rai, Nagendra Rai, Shashi Pandey Rai
Salicylic acid (SA) and sodium nitroprusside (SNP, NO donor) modulates plant growth and development processes and recent findings have also revealed their involvement in the regulation of epigenetic factors under stress condition. In the present study, some of these factors were comparatively studied in hyacinth bean plants subjected to high temperature (HT) environment (40-42 °C) with and without exogenous application of SA and SNP under field condition. Exogenous application of SA and SNP substantially modulated the growth and biophysical process of hyacinth bean plants under HT environment...
April 26, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29762848/cxcr3-mediates-chondrocyte-injury-through-regulating-nitric-oxide
#5
Z-C Yin, W-H Xiong, Q-J Pang
OBJECTIVE: As a common joint disease, osteoarthritis exhibits increasing trend in recent years. C-X-C motif chemokine receptor 3 (CXCR3) is a kind of chemokine with the characteristic of recruiting inflammatory cells. Its function in osteoarthritis has not been clarified. This study aims to explore the role of CXCR3 in cartilage injury by affecting unfolded protein response (UPR) pathway. PATIENTS AND METHODS: The sample was obtained from osteoarthritis patients to test CXCR3 expression by Real-time polymerase chain reaction (PCR)...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29756401/alpha-1-adrenergic-stimulation-selectively-enhances-endothelium-mediated-vasodilation-in-rat-cremaster-arteries
#6
Ramesh C Mishra, Mohammad M Rahman, Michael J Davis, Heike Wulff, Michael A Hill, Andrew P Braun
We have systematically investigated how vascular smooth muscle α1 -adrenoceptor activation impacts endothelium-mediated vasodilation in isolated, myogenically active, rat cremaster muscle 1A arteries. Cannulated cremaster arteries were pressurized intraluminally to 70 mmHg to induce myogenic tone, and exposed to vasoactive agents via bath superfusion at 34°C. Smooth muscle membrane potential was measured via sharp microelectrode recordings in pressurized, myogenic arteries. The α1 -adrenergic agonist phenylephrine (25-100 nmol/L) produced further constriction of myogenic arteries, but did not alter the vasorelaxant responses to acetylcholine (0...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29753043/ska-31-an-activator-of-endothelial-ca-2-activated-k-channels-evokes-robust-vasodilation-in-rat-mesenteric-arteries
#7
Rayan Khaddaj-Mallat, Cini Mathew John, Andrew P Braun
It is now well recognized that endothelial KCa2.3 and KCa3.1 channel activities contribute to dilation of resistance arteries via endothelium-mediated hyperpolarization and vascular smooth muscle relaxation. In this study, we have investigated the functional effect of the KCa channel activator SKA-31 in third order rat mesenteric arteries using arterial pressure myography. Isolated arteries were cannulated, pressurized intraluminally to 70mmHg at 36°C and then constricted with 1μM phenylephrine. Acute bath exposure to SKA-31 evoked a robust and reversible inhibition of developed tone (IC50 = 0...
May 9, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29736248/reactive-oxygen-species-and-nitric-oxide-induce-senescence-of-rudimentary-leaves-and-the-expression-profiles-of-the-related-genes-in-litchi-chinensis
#8
Haifang Yang, Hye-Ji Kim, Houbin Chen, Yong Lu, Xingyu Lu, Congcong Wang, Biyan Zhou
Litchi is one of the most important subtropical evergreen fruit trees in southern Asia. Previous studies indicated that high-temperature conditions encourage growth of rudimentary leaves in panicles and suppress flowering. We have demonstrated that methyl viologen dichloride hydrate (MV) and sodium nitroprusside (SNP) promoted flowering in litchi partially by inhibiting the growth of rudimentary leaves via reactive oxygen species (ROS) and nitric oxide (NO). In the present study, we examined the microstructure and ultrastructure, programmed cell death (PCD) ratio, nuclei morphology of the rudimentary leaves, and the expression of senescence-related genes after the treatment with ROS or NO...
2018: Horticulture Research
https://www.readbyqxmd.com/read/29736154/decreased-il-33-production-contributes-to-trophoblast-cell-dysfunction-in-pregnancies-with-preeclampsia
#9
Hong Chen, Xiaobo Zhou, Ting-Li Han, Philip N Baker, Hongbo Qi, Hua Zhang
Preeclampsia (PE) is a life-threatening pregnancy complication which is related to aggradation of risk regarding fetal and maternal morbidity and mortality. Dysregulation of systemic inflammatory response and dysfunction of trophoblast cells have been proposed to be involved in the development and progression of PE. Some studies have demonstrated that interleukin-33 (IL-33) is an immunomodulatory cytokine that is associated with the immune regulation of tumor cells. However, little is known whether IL-33 and its receptor ST2/IL-1 R4 could regulate trophoblast cells, which are associated with the pathogenesis of PE...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29735632/endothelial-ppar%C3%AE-peroxisome-proliferator-activated-receptor-%C3%AE-is-essential-for-preventing-endothelial-dysfunction-with-aging
#10
T Michael De Silva, Ying Li, Dale A Kinzenbaw, Curt D Sigmund, Frank M Faraci
Little is known about mechanisms that control vascular aging, particularly at the cell-specific level. PPARγ (peroxisome proliferator-activated receptor-γ) exerts protective effects in the vasculature when activated pharmacologically. To gain insight into the cell-specific impact of PPARγ, we examined the hypothesis that genetic interference with endothelial PPARγ would augment age-induced vascular dysfunction. We studied carotid arteries from adult (11.6±0.3 months) and old (24.7±0.6 months) mice with endothelial-specific expression of a human dominant negative mutation in PPARγ driven by the vascular cadherin promoter (E-V290M), along with age-matched, nontransgenic littermates...
May 7, 2018: Hypertension
https://www.readbyqxmd.com/read/29728013/coronary-and-peripheral-vasomotor-responses-to-mental-stress
#11
Muhammad Hammadah, Jeong Hwan Kim, Ibhar Al Mheid, Ayman Samman Tahhan, Kobina Wilmot, Ronnie Ramadan, Ayman Alkhoder, Mohamed Khayata, Girum Mekonnen, Oleksiy Levantsevych, Yasir Bouchi, Belal Kaseer, Fahad Choudhary, Mohamad M Gafeer, Frank E Corrigan, Amit J Shah, Laura Ward, Michael Kutner, J Douglas Bremner, David S Sheps, Paolo Raggi, Viola Vaccarino, Habib Samady, Kreton Mavromatis, Arshed A Quyyumi
BACKGROUND: Coronary microvascular dysfunction may contribute to myocardial ischemia during mental stress (MS). However, the role of coronary epicardial and microvascular function in regulating coronary blood flow (CBF) responses during MS remains understudied. We hypothesized that coronary vasomotion during MS is dependent on the coronary microvascular endothelial function and will be reflected in the peripheral microvascular circulation. METHODS AND RESULTS: In 38 patients aged 59±8 years undergoing coronary angiography, endothelium-dependent and endothelium-independent coronary epicardial and microvascular responses were measured using intracoronary acetylcholine and nitroprusside, respectively, and after MS induced by mental arithmetic testing...
May 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29727795/differential-effects-of-high-consumption-of-fructose-or-glucose-on-mesenteric-arterial-function-in-female-rats
#12
Sonali Shaligram, Gemma Sangüesa, Farjana Akther, Marta Alegret, Juan C Laguna, Roshanak Rahimian
We have recently shown that type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic endothelial function in female rats. The aim of the current study was to investigate and compare the effects of high consumption of glucose or fructose on mesenteric arterial reactivity and systolic blood pressure (SBP). Sprague-Dawley female rats were supplemented with 20% w/v glucose or fructose in drinking water for 8 weeks. Here, we show that both sugars alter insulin signaling in mesenteric arteries (MA), assessed by a reduction in phosphorylated Akt, and increase in SBP...
April 3, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29727217/arteriolar-vasodilation-involves-actin-depolymerization
#13
Philip S Clifford, Brian S Ferguson, Jeffrey L Jasperse, Michael A Hill
It is generally assumed that relaxation of arteriolar vascular smooth muscle occurs through hyperpolarization of the cell membrane, reduction in intracellular calcium concentration, and activation of myosin light chain phosphatase/inactivation of myosin light chain kinase. We hypothesized that vasodilation is related to depolymerization of F-actin. Cremaster muscles were dissected from rats under sodium pentobarbital anesthesia (50mg/kg). 1A arterioles were dissected, cannulated on glass micropipettes, pressurized, and warmed to 34{degree sign}C...
May 4, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29726480/intracoronary-nicorandil-and-the-prevention-of-the-no-reflow-phenomenon-during-primary-percutaneous-coronary-intervention-in-patients-with-acute-st-segment-elevation-myocardial-infarction
#14
Qi Qi, Jinghui Niu, Tao Chen, Hongshan Yin, Tao Wang, Zhian Jiang
BACKGROUND This study aimed to investigate intracoronary nicorandil treatment on the no-reflow phenomenon (NRP) during primary percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) and to compare nicorandil with sodium nitroprusside. MATERIAL AND METHODS Patients with sustained acute STEMI who underwent primary PCI (N=120) were randomly assigned to three groups: the nicorandil-treated group (N=40) had 2 mg of nicorandil injected into the coronary artery at 2 mm beyond the occlusion with balloon pre-dilation; the sodium nitroprusside-treated group (N=40) underwent the same procedure, but with 200 μg of sodium nitroprusside; the control group (N=40) received PCI and balloon pre-dilation only...
May 4, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29722620/elevated-extracellular-potassium-prior-to-muscle-contraction-reduces-onset-and-steady-state-exercise-hyperemia-in-humans
#15
Janée D Terwoord, Christopher M Hearon, Gary J Luckasen, Jennifer C Richards, Michael J Joyner, Frank A Dinenno
The increase in interstitial potassium (K+ ) during muscle contractions is thought to be a vasodilatory signal that contributes to exercise hyperemia. To determine the role of extracellular K+ in exercise hyperemia, we perfused skeletal muscle with K+ prior to contractions such that the effect of any endogenously-released K+ would be minimized. We tested the hypothesis that local, intra-arterial infusion of potassium chloride (KCl) at rest would impair vasodilation in response to subsequent rhythmic handgrip exercise in humans...
May 3, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29716662/nitric-oxide-balances-osteoblast-and-adipocyte-lineage-differentiation-via-the-jnk-mapk-signaling-pathway-in-periodontal-ligament-stem-cells
#16
Shan Yang, Lijia Guo, Yingying Su, Jing Wen, Juan Du, Xiaoyan Li, Yitong Liu, Jie Feng, Yongmei Xie, Yuxing Bai, Hao Wang, Yi Liu
BACKGROUND: Critical tissues that undergo regeneration in periodontal tissue are of mesenchymal origin; thus, investigating the regulatory mechanisms underlying the fate of periodontal ligament stem cells could be beneficial for application in periodontal tissue regeneration. Nitric oxide (NO) regulates many biological processes in developing embryos and adult stem cells. The present study was designed to investigate the effects of NO on the function of human periodontal ligament stem cells (PDLSCs) as well as to elucidate the underlying molecular mechanisms...
May 2, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29709920/impairment-of-protease-activated-receptor-2-induced-relaxation-of-aortas-of-aged-spontaneously-hypertensive-rat
#17
Makoto Ando, Takayuki Matsumoto, Shota Kobayashi, Maika Iguchi, Kumiko Taguchi, Tsuneo Kobayashi
Hypertension is one of the most prevalent diseases worldwide and can cause harmful complications within the vascular system. Further research on vascular responsiveness to different ligands and diverse receptors in various arteries is required to understand the mechanisms underlying the development of these vascular complications. Here, we investigated the vasorelaxant effect of the protease-activated receptor 2 (PAR2) agonist 2-furoyl-LIGRLO-amide (2-Fly) and two commonest agents, namely endothelium-dependent dilator acetylcholine (ACh) and endothelium-independent dilator sodium nitroprusside (SNP), on the thoracic aorta isolated from aged spontaneously hypertensive rats (SHR) (age, 52±1 weeks)...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29707746/chronic-cadmium-exposure-accelerates-the-development-of-atherosclerosis-and-induces-vascular-dysfunction-in-the-aorta-of-apoe-mice
#18
T F Oliveira, P R Batista, M A Leal, B P Campagnaro, B V Nogueira, D V Vassallo, S S Meyrelles, Alessandra Simão Padilha
Cadmium exposure is related to cardiovascular diseases, including hypertension, atherosclerosis, increased oxidative stress, endothelial dysfunction, and specific biochemical changes induced by this metal. Thus, we aimed to investigate whether cadmium exposure induces endothelial dysfunction, accelerates atherosclerotic plaque formation in the aorta, and enhances oxidative stress in apolipoprotein E knockout (ApoE-/- ) mice. Experiments were performed in 14-week-old male wild-type and ApoE-/- mice. ApoE-/- mice received cadmium (CdCl2 100 mg/L in drinking water for 28 days) or vehicle (distilled water)...
April 29, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29707481/brugada-type-electrocardiogram-changes-associated-with-nitroprusside-toxicity
#19
Jonathan T Jaffe, Lee-Gardie Jean, Richard J Murray
No abstract text is available yet for this article.
March 2018: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/29703207/sglt2-inhibition-via-dapagliflozin-improves-generalized-vascular-dysfunction-and-alters-the-gut-microbiota-in-type-2-diabetic-mice
#20
Dustin M Lee, Micah L Battson, Dillon K Jarrell, Shuofei Hou, Kayl E Ecton, Tiffany L Weir, Christopher L Gentile
BACKGROUND: Type 2 diabetes (T2D) is associated with generalized vascular dysfunction characterized by increases in large artery stiffness, endothelial dysfunction, and vascular smooth muscle dysfunction. Sodium glucose cotransporter 2 inhibitors (SGLT2i) represent the most recently approved class of oral medications for the treatment of T2D, and have been shown to reduce cardiovascular and overall mortality. Although it is currently unclear how SGLT2i decrease cardiovascular risk, an improvement in vascular function is one potential mechanism...
April 27, 2018: Cardiovascular Diabetology
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