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Early pregnancy loss

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https://www.readbyqxmd.com/read/28214760/genotyping-analysis-of-protein-s-tokushima-k196e-and-the-involvement-of-protein-s-antigen-and-activity-in-patients-with-recurrent-pregnancy-loss
#1
Yasushi Matsukawa, Eriko Asano, Tomohide Tsuda, Hiroyuki Kuma, Tamao Kitaori, Kinue Katano, Yasuhiko Ozaki, Mayumi Sugiura-Ogasawara
OBJECTIVE: Preston et al. indicated that Protein S (PS) deficiency was associated with stillbirths but not miscarriages. The PS-Tokushima missense variant was reported to serve as a genetic risk factor for deep vein thrombosis in the Japanese population. A previous cross-sectional study showed no increase in the prevalence of PS-Tokushima in patients with recurrent early pregnancy loss or in patients with intra uterine fetal death and/or fetal growth restriction. There has been limited number of prospective studies examining the pregnancy outcome in patients with both a PS deficiency and recurrent pregnancy loss (RPL)...
February 8, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28183999/gain-of-function-%C3%AE-catenin-in-uterine-mesenchyme-leads-to-impaired-implantation-and-decidualization
#2
Amanda Lynn Patterson, Jamieson Pirochta, Stephanie Tufano, Jose Teixeira
Embryo implantation and endometrial decidualization are critical events that occur during early pregnancy in humans and mice, and perturbation in either can result in infertility. WNT signaling through the canonical β-catenin pathway plays a pivotal role in embryonic Müllerian duct development, postnatal uterine maturation, and establishment of pregnancy. Loss of β-catenin in the Müllerian duct mesenchyme (MDM)-derived stroma and myometrium results in impaired decidualization and infertility; whereas gain of function (GOF) results in formation of mesenchymal tumors and sub-fertility attributed to malformed oviducts...
February 9, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28183365/calm-merino-ewes-have-a-higher-ovulation-rate-and-more-multiple-pregnancies-than-nervous-ewes
#3
E van Lier, K W Hart, C Viñoles, B Paganoni, D Blache
In 1990, two selection lines of Merino sheep were established for low and high behavioural reactivity (calm and nervous temperament) at the University of Western Australia. Breeding records consistently showed that calm ewes weaned 10% to 19% more lambs than the nervous ewes. We hypothesise that calm ewes could have a higher ovulation rate than nervous ewes and/or calm ewes could have a lower rate of embryo mortality than nervous ewes. We tested these hypotheses by comparing the ovulation rate and the rate of embryo mortality between the calm and nervous lines before and after synchronisation and artificial insemination...
February 10, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28179267/obesity-and-pregnancy-mechanisms-of-short-term-and-long-term-adverse-consequences-for-mother-and-child
#4
REVIEW
Patrick M Catalano, Kartik Shankar
Obesity is the most common medical condition in women of reproductive age. Obesity during pregnancy has short term and long term adverse consequences for both mother and child. Obesity causes problems with infertility, and in early gestation it causes spontaneous pregnancy loss and congenital anomalies. Metabolically, obese women have increased insulin resistance in early pregnancy, which becomes manifest clinically in late gestation as glucose intolerance and fetal overgrowth. At term, the risk of cesarean delivery and wound complications is increased...
February 8, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28179198/cesarean-scar-ectopic-pregnancy-laparoscopic-resection-and-total-scar-dehiscence-repair-a-case-report
#5
Sara Mahgoub, Victor Gabriele, Emilie Faller, Bruno Langer, Arnaud Wattiez, Lise Lecointre, Cherif Akladios
STUDY OBJECTIVE: Illustrate laparoscopic technique for resection of cesarean scar ectopic pregnancy, associated with isthmocele repair. DESIGN: Case report SETTING: Tertiary referral centre in Strasbourg, France. The study was approved by the local IRB. BACKGROUND: Cesarean scar pregnancy is a rare form of ectopic pregnancy. The major risk of this type of pregnancy is the early uterine rupture with massive bleeding and maternal life-threatening...
February 4, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28176447/statins-during-pregnancy-a-cohort-study-using-the-general-practice-research-database-to-investigate-pregnancy-loss
#6
Anita McGrogan, Julia Snowball, Rachel A Charlton
PURPOSE: The aim of this study was to determine if there are any differences between the types of pregnancy loss experienced by women who have been prescribed a statin just before or early in pregnancy compared with those who have not. METHODS: A retrospective cohort study using the General Practice Research Database was carried out. Women aged 10-49 years at pregnancy start who received a prescription for a statin in the 3 months before and/or during the first trimester of pregnancy were matched to up to 10 pregnancies on age at start date, diabetes and hypertension status before pregnancy...
February 8, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28167020/early-childhood-otitis-media-and-later-school-performance-a-prospective-cohort-study-of-associations
#7
Vincent Fougner, Asbjørn Kørvel-Hanquist, Anders Koch, Jesper Dammeyer, Janni Niclasen, Jørgen Lous, Preben Homøe
INTRODUCTION: Otitis media (OM) is a common disease in childhood and hearing loss (HL) is the most common complication. Prolonged HL may lead to language delay and cognitive difficulties. However, the consequences of HL due to OM are not fully understood. The aim of this study was to determine the possible association between number of OM episodes in childhood and self-rated school performance controlling for potential confounders. METHODS: Prospectively gathered systematic interview data on OM episodes in early childhood and school performance at 11 years of age were obtained from The Danish National Birth Cohort, involving >100,000 individual pregnancies and their offspring...
March 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28166975/impact-of-a-killed-tritrichomonas-foetus-vaccine-on-clearance-of-the-organism-and-subsequent-fertility-of-heifers-following-experimental-inoculation
#8
Misty A Edmondson, Kellye S Joiner, Jennifer A Spencer, Kay P Riddell, Soren P Rodning, Julie A Gard, M Daniel Givens
Tritrichomonas foetus is a sexually transmitted reproductive pathogen of cattle that causes transient infertility, early embryonic death, metritis, pyometra, and sporadic abortions. The objective of this research was to assess the impact on reproductive health of vaccinating naïve heifers with a killed T. foetus vaccine (TrichGuard) before experimental exposure followed by breeding. A total of 40 beef heifers were randomly assigned into two treatment groups. Heifers where then vaccinated with two doses of TrichGuard or sham vaccinated with 0...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28166972/comparison-between-allantochorion-membrane-and-amniotic-sac-detection-by-per-rectal-palpation-for-pregnancy-diagnosis-on-pregnancy-loss-calving-rates-and-abnormalities-in-newborn-calves
#9
Juan E Romano, Pablo Pinedo, Kelsey Bryan, Roney S Ramos, Karol G Solano, Daniel Merchan, Juan Velez
The objectives of the present investigation were to evaluate the pregnancy diagnosis by detection of either the allantochorion membrane (FMS) or amniotic sac (ASP) by per rectum palpation (PRP) during late embryonic or early fetal period on pregnancy loss (PRL) at reexamination, calving rates, and abnormalities in newborn calves. A controlled randomized blind design with 800 lactating dairy pregnant cows diagnosed by transrectal ultrasonography (TRUS) between Days 35 and 57 of gestation from one dairy farm were included...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28166969/progesterone-supplementation-in-the-early-luteal-phase-after-artificial-insemination-improves-conception-rates-in-high-producing-dairy-cows
#10
I Garcia-Ispierto, F López-Gatius
This study examines the possible effects on the reproductive performance of high-producing dairy cows of progesterone (P4) given in the early luteal phase (1.55 g of P4), from Days 3 to 5 post-artificial insemination (AI) as compared with the time of pregnancy recognition, from Days 15 to 17 post-AI. Cows in their third day post-AI were alternately assigned on a weekly rotational basis to the following groups: control, no treatment (C: n = 351), P4 treatment started 15 days after AI (P4-D15: n = 261), or P4 treatment started 3 days after AI (P4-D3: n = 203)...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28161167/ability-of-dairy-cows-to-ensure-pregnancy-according-to-breed-and-genetic-merit-for-production-traits-under-contrasted-pasture-based-systems
#11
N Bedere, C Disenhaus, V Ducrocq, S Leurent-Colette, L Delaby
The present study aimed to assess and measure the effects of breed, genetic merit for production traits, and feeding systems (FS) on the ability of dairy cows to ensure pregnancy through its components (fertilization, embryonic losses, recalving). An experiment was conducted over 9 yr on Normande and Holstein cows assigned to contrasted FS. Diets were based on maize silage in winter and grazing plus concentrate in spring in the high FS group, and on grass silage in winter and grazing with no concentrate during spring in the low FS group...
February 1, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28161055/maternal-type-1-diabetes-activates-stress-response-in-early-placenta
#12
Martin Gauster, Alejandro Majali-Martinez, Sabine Maninger, Elisabeth Gutschi, Patrick H Greimel, Marina Ivanisevic, Josip Djelmis, Gernot Desoye, Ursula Hiden
INTRODUCTION: Human pregnancy and in particular the first trimester, is a period highly susceptible towards adverse insults such as oxidative stress, which may lead to inadequate embryonic and feto-placental development. Diabetes mellitus is associated with increased oxidative stress caused by hyperglycemia, reactive oxygen species (ROS) production and inflammatory signals. In pregnancy, diabetes elevates the risk for early pregnancy loss, preeclampsia and fetal growth restriction, pathologies that origin from early placental maldevelopment...
February 2017: Placenta
https://www.readbyqxmd.com/read/28157383/biomarkers-of-oxidative-stress-in-pregnancy-complications
#13
James Sm Cuffe, Ziheng Calvin Xu, Anthony V Perkins
Pregnancy complications including pre-eclampsia, gestational-diabetes mellitus, preterm birth and intrauterine growth restriction can cause acute and chronic health problems for the mother and lead to fetal loss or dysregulation of infant physiology. The human placenta is susceptible to oxidative stress and oxidative damage in early gestation contributes to the onset of these conditions later in pregnancy. Current methods of predicting pregnancy complications are limited and although a large number of factors are associated with disease progression, few biomarkers have been used to aid in disease diagnosis early in gestation...
February 3, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28145985/left-truncation-bias-to-explain-the-protective-effect-of-smoking-on-preeclampsia-potential-but-how-plausible
#14
Alan C Kinlaw, Jessie P Buckley, Stephanie M Engel, Charles Poole, M Alan Brookhart, Alexander P Keil
BACKGROUND: An inverse association between maternal smoking and preeclampsia has been frequently observed in epidemiologic studies for several decades. In the May 2015 issue of this journal, Lisonkova and Joseph described a simulation study suggesting that bias from left truncation might explain the inverse association. The simulations were based on strong assumptions regarding the underlying mechanisms through which bias might occur. METHODS: To examine the sensitivity of the previous authors' conclusions to these assumptions, we constructed a new Monte Carlo simulation using published estimates to frame our data generating parameters...
January 31, 2017: Epidemiology
https://www.readbyqxmd.com/read/28142289/time-lapse-imaging-is-it-time-to-incorporate-this-technology-into-routine-clinical-practice
#15
Priya Bhide, Abha Maheshwari, Rachel Cutting, Susan Seenan, Anita Patel, Khalid Khan, Roy Homburg
Time-lapse imaging (TLI) systems for embryo incubation, assessment and selection are a novel technology available to in vitro fertilization (IVF) clinics. However, there is uncertainty about their clinical and cost-effectiveness and insufficient good quality evidence to warrant their routine use. Despite this, enthusiastic commercial marketing and slipping clinical equipoise have led to the widespread hasty introduction of this technology into practice, often at a considerable expense to the patient. We have reviewed the published literature and aim to summarize the strengths, weaknesses, opportunities and threats of these systems...
February 1, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28140620/effects-of-lactoferrin-in-6-patients-with-refractory-bacterial-vaginosis
#16
Katsufumi Otsuki, Noriaki Imai
We previously reported that lactoferrin (LF) could be effective for preventing preterm delivery and intrauterine infections, based on data derived from mice and rabbits. Here we describe 6 women with a history of multiple pregnancy losses or preterm delivery and refractory bacterial vaginosis, who received prebiotic LF therapy and delivered an infant normally. Five of the women were pregnant and one was not at the time of this study. The Ethics Committee at Showa University Hospital and Showa University Koto Toyosu Hospital approved the therapeutic protocol...
February 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28139950/can-early-%C3%AE-human-chorionic-gonadotropin-predict-birth-of-singletons-and-twins-after-in-vitro-fertilization
#17
Ana Póvoa, Milton Severo, Pedro Xavier, Alexandra Matias, Isaac Blickstein
OBJECTIVE: To assess the predictive value for clinical pregnancy outcome of β-hCG level at 13 days after embryo transfer. METHODS: Retrospective study of IVF clinical pregnancies diagnosed at 6 weeks. We calculated the value of β-hCG level at 13 days after embryo transfer to predict live births. RESULTS: We analyzed 177 IVF cycles between 2009 and 2014 (50 singleton births, 50 twin births, 27 sets with a vanishing twin, 43 first trimester singleton pregnancy loss and 7 first trimester total twin pregnancy loss)...
January 31, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28130684/clinical-characteristics-and-laboratory-findings-of-252-chinese-patients-with-anti-phospholipid-syndrome-comparison-with-euro-phospholipid-cohort
#18
Hui Shi, Jia-Lin Teng, Yue Sun, Xin-Yao Wu, Qiong-Yi Hu, Hong-Lei Liu, Xiao-Bing Cheng, Yu-Feng Yin, Jun-Na Ye, Pojen P Chen, Cheng-de Yang
This study aims to characterize the Chinese Han patients with anti-phospholipid syndrome (APS) and compare the data with those of the Euro-Phospholipid cohort. We conducted a single center study consisting of 252 patients with definite APS from 2000 to 2015. We analyzed the clinical and laboratory characteristics of our cohort and compared the data with those of the Euro-Phospholipid cohort. Our cohort consisted of 216 females and 36 males, with a mean age at entry into this study of 41 years (range 11-74 years)...
January 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28126966/obstetric-antiphospholipid-syndrome-early-variations-of-angiogenic-factors-are-associated-with-adverse-outcomes-the-noh-angio-observational-cohort-study
#19
Éva Cochery-Nouvellon, Érick Mercier, Sylvie Bouvier, Jean-Pierre Balducchi, Isabelle Quéré, Antonia Perez-Martin, Eve Mousty, Vincent Letouzey, Jean-Christophe Gris
The prognostic value of angiogenic factors in newly pregnant women with obstetric antiphospholipid syndrome has not been documented. We observed 513 obstetric antiphospholipid syndromes who experienced three consecutive spontaneous abortions before the 10th week of gestation or one fetal loss at or beyond the 10th week. We assessed the plasma concentrations of the proangiogenic factor placenta growth factor and of the antiangiogenic factor soluble fms-like tyrosine kinase-1 on the eve and on the 4th day of the low-molecular weight heparin-low dose aspirin treatment...
January 25, 2017: Haematologica
https://www.readbyqxmd.com/read/28126366/testing-for-zika-virus-infection-in-pregnancy-key-concepts-to-deal-with-an-emerging-epidemic
#20
REVIEW
Catherine Eppes, Martha Rac, James Dunn, James Versalovic, Kristy O Murray, Melissa A Suter, Magda Sanz Cortes, Jimmy Espinoza, Maxim D Seferovic, Wesley Lee, Peter Hotez, Joan Mastrobattista, Steven L Clark, Michael A Belfort, Kjersti M Aagaard
Zika virus is an emerging mosquito-borne (Aedes genus) arbovirus of the Flaviviridae family. Following epidemics in Micronesia and French Polynesia during the past decade, more recent Zika virus infection outbreaks were first reported in South America as early as May 2013 and spread to now 50 countries throughout the Americas. Although no other flavivirus has previously been known to cause major fetal malformations following perinatal infection, reports of a causal link between Zika virus and microcephaly, brain and ocular malformations, and fetal loss emerged from hard-hit regions of Brazil by October 2015...
January 23, 2017: American Journal of Obstetrics and Gynecology
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