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https://www.readbyqxmd.com/read/27928435/a-debate-about-ultrasound-and-anatomic-aspects-of-the-cervix-in-spontaneous-preterm-birth
#1
REVIEW
Bohîlțea Re, Munteanu O, Turcan N, Baros A, Bodean O, Voicu D, Cîrstoiu Mm
Preterm birth is the legal first global cause of neonatal death. The cervix has two roles: it has to stay closed to allow the fetus to undergo a normal development during gestation, and at term, the cervix has to dilate under the pressure of uterine contractions to allow the delivery. The purpose of this article is to establish if the ultrasound measured length of the cervix and its appearance are predictive for the spontaneous preterm birth. Cervical insufficiency can be described by painless cervical dilatation leading to pregnancy losses/ births, with no other risk factors present...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27924832/impaired-receptivity-and-decidualization-in-dhea-induced-pcos-mice
#2
Shu-Yun Li, Zhuo Song, Min-Jie Song, Jia-Wen Qin, Meng-Long Zhao, Zeng-Ming Yang
Polycystic ovary syndrome (PCOS), a complex endocrine disorder, is a leading cause of female infertility. An obvious reason for infertility in PCOS women is anovulation. However, success rate with high quality embryos selected by assisted reproduction techniques in PCOS patients still remain low with a high rate of early clinical pregnancy loss, suggesting a problem in uterine receptivity. Using a dehydroepiandrosterone-induced mouse model of PCOS, some potential causes of decreased fertility in PCOS patients were explored...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27891347/decidual-cd56-natural-killer-cells-in-spontaneous-early-pregnancy-loss-an-immunohistochemical-study
#3
Balamurugan Senthilnayagam, Sridhar Karthikeyan, Jayapriya Sukumaran, Anoop Srivalsan, Ramesh Rao, Vasantha Subbiah
INTRODUCTION: Natural killer cells are believed to promote placental and trophoblastic growth and provide immune- modulation at maternal-fetal interface in pregnancy and their role in reproductive failure has been a matter of discussion. AIM: To study CD56+ Natural killer cells in spontaneous pregnancy loss. MATERIALS AND METHODS: In this prospective observational study, formalin-fixed paraffin embedded sections from products of conception from twenty women each with spontaneous early pregnancy loss (test group) and elective pregnancy termination (control group)...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27888752/factors-influencing-brain-natriuretic-peptide-levels-in-healthy-pregnant-women
#4
Michinori Mayama, Masato Yoshihara, Kaname Uno, Sho Tano, Takehiko Takeda, Mayu Ukai, Yasuyuki Kishigami, Hidenori Oguchi
BACKGROUND: The normal range of plasma brain natriuretic peptide (BNP) in pregnant women is still unclear. Moreover, pregnant women experience dynamic body weight changes and suffer from anemia, but effects on maternal BNP have not been investigated. This study aimed to reveal the normal plasma BNP range and examine the effects of physiological changes on BNP among pregnant women. METHODS AND RESULTS: Plasma BNP, hemoglobin, plasma creatinine and BMI were measured in 58 non-pregnant control women and in 773 normal pregnant women at late pregnancy, early postpartum and 1-month postpartum...
November 10, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27888033/prenatal-intake-of-vitamins-and-allergic-outcomes-in-the-offspring-a-systematic-review-and-meta-analysis
#5
Mariam Vahdaninia, Heather Mackenzie, Suzannah Helps, Taraneh Dean
BACKGROUND: Allergic diseases have seen a rise worldwide, with children suffering the highest burden. Thus, early prevention of allergic diseases is a public health priority. OBJECTIVE: To synthesize the evidence from randomized controlled trials (RCTs) assessing the effect of vitamin interventions during pregnancy on developing allergic diseases in offspring. METHODS: We searched CENTRAL, MEDLINE, SCOPUS, World Health Organization's International Clinical Trials Registration, E-theses, and Web of Science...
November 22, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27882764/-acute-pancreatitis-in-pregnancy-complicated-by-rupture-of%C3%A2-aneurysm-of-artery-lienalis
#6
E Hostinská, K Huml, R Pilka
OBJECTIVE: We present a case of pregnant woman with acute pacreatitis in 38th week comlicated by acute rupture of aneurysm of artery lienalis. DESIGN: Case report. SETTING: Department of Gynaecology and Obstetrics, Faculty Hospital and Palacky University, Olomouc. CASE REPORT: 28-years-old primipara in 38th week of gestation was admitted to our department for acute pancreatitis caused by gallstones. Subsequent conservative treatment was complicated by rupture of aneurysm of lienal artery and haemorrhagic shock...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27871478/transendothelial-migration-of-human-umbilical-mesenchymal-stem-cells-across-uterine-endothelial-monolayers-junctional-dynamics-and-putative-mechanisms
#7
Neven A Ebrahim, Lopa Leach
INTRODUCTION: During pregnancy, fetal stem cells can transfer to the maternal circulation and participate in tissue repair. How they transmigrate across maternal endothelial barriers and whether they can subsequently influence maternal endothelial integrity is not known. METHODS: Mesenchymal stem cells (WJ-MSC) were isolated from Wharton's jelly and their interactions with human uterine microvascular endothelial cell (HUtMEC) monolayers, junctional occupancy and expression/phosphorylation of vascular endothelial (VE)- cadherin and vascular endothelial growth factor (VEGF-A) secretion was studied over 48h by real time, confocal microscopy, immunoblotting and ELISA...
December 2016: Placenta
https://www.readbyqxmd.com/read/27871060/involvement-of-serum-glucocorticoid-regulated-kinase-1-in-reproductive-success
#8
REVIEW
Yiyun Lou, Minhao Hu, Luna Mao, Yingming Zheng, Fan Jin
Reproductive processes, in particular events that concern pregnancy, are fine-tuned to produce offspring. Reproductive success is of prime importance for the survival of every species. The highly conserved and ubiquitously expressed serum glucocorticoid-regulated kinase 1 (SGK1) was first implicated in infertility as a regulator of a Na(+) channel. In this review, we emphasize the prominent role of SGK1 during early pregnancy: 1) balancing uterine luminal fluid secretion and reabsorption to aid blastocyst adhesion and to import nutrients and energy; 2) transducing signals from the blastocyst to the receptive endometrium; 3) inducing multiple genes that are involved in uterine receptivity and trophoblast invasion; 4) regulating cell differentiation and antioxidant defenses at the fetomaternal interface; and 5) contributing to the proliferation and survival of decidual stromal cells...
November 9, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27869777/the-effects-of-mild-gestational-hyperglycemia-on-exclusive-breastfeeding-cessation
#9
Sergio Verd, Diego de Sotto, Consuelo Fernández, Antonio Gutiérrez
Gestational diabetes increases the risk of a range of adverse perinatal outcomes, including breastfeeding failure, but the best cut-off point for gestational diabetes is unknown. The purpose of this study was to evaluate the association between mild gestational glucose tolerance impairment and the early cessation of exclusive breastfeeding (EBF). This is an observational study of 768 women with full term pregnancies that were screened for gestational diabetes at 24-28 weeks gestation. Subjects were divided into two groups: those with a normal 1-h glucose challenge test and those with an elevated 1-h glucose challenge test but still did not qualify for gestational diabetes...
November 19, 2016: Nutrients
https://www.readbyqxmd.com/read/27854392/association-between-three-dimensional-transvaginal-sonographic-markers-and-outcome-of-pregnancy-of-unknown-location-a-pilot-study
#10
S Reid, B Nadim, T Bignardi, C Lu, W P Martins, G Condous
OBJECTIVE: To assess the accuracy of three-dimensional (3D) transvaginal sonographic (TVS) parameters in predicting the evolution of a pregnancy of unknown location (PUL). METHODS: This was a prospective observational study performed at the early pregnancy unit of a university hospital from September 2008 to June 2012. Women with a positive pregnancy test without any signs of intra- or extrauterine pregnancy at their first TVS examination were considered eligible and a 3D dataset containing the entire uterus was acquired...
November 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27852922/abnormal-expression-of-trail-receptors-in-decidual-tissue-of-chlamydia-trachomatis-infected-rats-during-early-pregnancy-loss
#11
Jinzhi Lu, Liya Zhu, Lei Zhang, Jinpeng Jiang, Fang Xie, Qing Huang, Xiaolan Li, Cunjian Yi
Chlamydia trachomatis is the scientific name of pathogenic bacteria causing infection that has been linked to spontaneous abortion. In this study, the expression pattern of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL; a cytokine related to cell apoptosis) and its receptors was monitored in the decidua of C trachomatis-infected pregnant rats during early gestation to investigate the potential role of this molecular system in C trachomatis-induced spontaneous abortion. The data showed that C trachomatis infection significantly altered the messenger RNA (mRNA) expression of the receptors; death receptor (DR) 4 and DR5 increased, but decoy receptor (DcR) 1 and DcR2 decreased...
November 16, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27849248/what-we-know-of-the-central-auditory-disorders-in-children-exposed-to-alcohol-during-pregnancy-systematic-review
#12
Humberto de Oliveira Simões, Sthella Zanchetta, Erikson Felipe Furtado
Purpose: To identify the effects of alcohol intake during pregnancy on the central auditory nervous system in relation to their possible diagnosis, Fetal Alcohol Syndrome, partial Fetal Alcohol Syndrome, Alcohol-Related Birth Defects and Alcohol-Related Neurodevelopmental Disorder, his extension and the hearing assessment method. Research strategy: Systematic and integrative review searched the databases PubMed, LILACS and SciELO, with terms in Portuguese and English "fetal alcohol syndrome", "alcohol-related disorders" associated with "hearing"...
September 2016: CoDAS
https://www.readbyqxmd.com/read/27836685/differential-expression-profile-of-long-noncoding-rnas-in-human-chorionic-villi-of-early-recurrent-miscarriage
#13
Leilei Wang, Huaiyun Tang, Yun Xiong, Lisha Tang
Miscarriage is the spontaneous loss of a pregnancy before the fetus reaching viability, including all pregnancy losses from the time of conception until 24weeks of gestation. Three or more times of consecutive spontaneous miscarriages is defined as recurrent miscarriage (RM). The underlying causes cannot be confirmed in nearly 50% of RM patients. We investigated the differential expression of long noncoding RNAs (lncRNAs) in chorionic villi tissues of RM patients compared with normal women, and their possible involvement in the pathogenic pathways leading to RM...
November 9, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27829074/fetal-outcomes-following-emergency-department-point-of-care-ultrasound-for-vaginal-bleeding-in-early-pregnancy
#14
Catherine Varner, Dahlia Balaban, Shelley McLeod, Sally Carver, Bjug Borgundvaag
OBJECTIVE: To determine 20- and 40-week fetal outcomes following documentation of fetal cardiac activity (FCA) and intrauterine pregnancy (IUP) in women at less than 20 weeks' gestation presenting to the emergency department (ED) with vaginal bleeding. DESIGN: Prospective observational cohort study. SETTING: Single-centre tertiary care ED. PARTICIPANTS: Pregnant women at less than 20 weeks' gestation presenting to the ED with vaginal bleeding...
July 2016: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/27824884/the-safety-of-artemisinin-derivatives-for-the-treatment-of-malaria-in-the-2nd-or-3rd-trimester-of-pregnancy-a-systematic-review-and-meta-analysis
#15
Stephanie D Kovacs, Anna Maria van Eijk, Esperanca Sevene, Stephanie Dellicour, Noel S Weiss, Scott Emerson, Richard Steketee, Feiko O Ter Kuile, Andy Stergachis
Given the high morbidity for mother and fetus associated with malaria in pregnancy, safe and efficacious drugs are needed for treatment. Artemisinin derivatives are the most effective antimalarials, but are associated with teratogenic and embryotoxic effects in animal models when used in early pregnancy. However, several organ systems are still under development later in pregnancy. We conducted a systematic review and meta-analysis of the occurrence of adverse pregnancy outcomes among women treated with artemisinins monotherapy or as artemisinin-based combination therapy during the 2nd or 3rd trimesters relative to pregnant women who received non-artemisinin antimalarials or none at all...
2016: PloS One
https://www.readbyqxmd.com/read/27817038/dna-methyltransferase-3a-promoter-polymorphism-is-associated-with-the-risk-of-human-spontaneous-abortion-after-assisted-reproduction-techniques-and-natural-conception
#16
Yudong Liu, Haiyan Zheng, Pingping Guo, Shuxian Feng, Xingyu Zhou, Desheng Ye, Xin Chen, Shiling Chen
PURPOSE: The aim of this study was to explore the association of the DNA-methyltransferase (DNMT)-3A and DNMT3B promoter polymorphisms with the risk of human spontaneous abortion after assisted reproduction techniques (ARTs) and natural conception. METHODS: We collected tissues from women who underwent abortion procedures: (a) chorionic villus samples (CVS) and muscle samples (MS) from spontaneous abortions conceived by ART and natural cycle (study group), n = 152; and (b) CVS and MS from normal early pregnancy and second trimester (control group), n = 155...
November 5, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27808369/molecular-thrombophilic-profile-in-mexican-patients-with-idiopathic-recurrent-pregnancy-loss
#17
J J López-Jiménez, Á Porras-Dorantes, C I Juárez-Vázquez, J E García-Ortiz, C A Fuentes-Chávez, I J Lara-Navarro, A R Jaloma-Cruz
Idiopathic recurrent pregnancy loss (IRPL) is defined by three or more consecutive miscarriages occurring before the twentieth week of gestation as a result of unidentified etiological factors. The results of previous studies have indicated that prothrombotic factors play a pathogenic role in early and late pregnancy. This study aimed to identify inherited prothrombotic and hypofibrinolytic risk factors in Mexican-Mestizo patients with IRPL. Fifty-six women with IRPL and 50 control women with at least two full-term pregnancies and no history of RPL were included in this case-control study...
October 5, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27807081/post-traumatic-stress-anxiety-and-depression-following-miscarriage-or-ectopic-pregnancy-a-prospective-cohort-study
#18
Jessica Farren, Maria Jalmbrant, Lieveke Ameye, Karen Joash, Nicola Mitchell-Jones, Sophie Tapp, Dirk Timmerman, Tom Bourne
OBJECTIVES: This is a pilot study to investigate the type and severity of emotional distress in women after early pregnancy loss (EPL), compared with a control group with ongoing pregnancies. The secondary aim was to assess whether miscarriage or ectopic pregnancy impacted differently on the type and severity of psychological morbidity. DESIGN: This was a prospective survey study. Consecutive women were recruited between January 2012 and July 2013. We emailed women a link to a survey 1, 3 and 9 months after a diagnosis of EPL, and 1 month after the diagnosis of a viable ongoing pregnancy...
November 2, 2016: BMJ Open
https://www.readbyqxmd.com/read/27799851/low-molecular-weight-heparin-can-benefit-women-with-recurrent-pregnancy-loss-and-sole-protein-s-deficiency-a-historical-control-cohort-study-from-taiwan
#19
Ming-Ching Shen, Wan-Ju Wu, Po-Jen Cheng, Gwo-Chin Ma, Wen-Chu Li, Jui-Der Liou, Cheng-Shyong Chang, Wen-Hsiang Lin, Ming Chen
BACKGROUND: Heritable thrombophilias are assumed important etiologies for recurrent pregnancy loss. Unlike in the Caucasian populations, protein S and protein C deficiencies, instead of Factor V Lieden and Prothrombin mutations, are relatively common in the Han Chinese population. In this study we aimed to investigate the therapeutic effect of low molecular weight heparin upon women with recurrent pregnancy loss and documented protein S deficiency. METHODS: During 2011-2016, 68 women with recurrent pregnancy loss (RPL) and protein S deficiency (both the free antigen and function of protein S were reduced) were initially enrolled...
2016: Thrombosis Journal
https://www.readbyqxmd.com/read/27796806/correlation-analysis-between-ultrasound-findings-and-abnormal-karyotypes-in-the-embryos-from-early-pregnancy-loss-after-in-vitro-fertilization-embryo-transfer
#20
Xihong Li, Yan Ouyang, Yan Yi, Yueqiu Tan, Guangxiu Lu
PURPOSE: The purpose of the study is to evaluate the correlation between ultrasound findings and abnormal karyotypes in early pregnancy losses (EPLs) after in vitro fertilization-embryo transfer (IVF-ET). METHODS: This retrospective analysis assessed 2172 cases of EPL after IVF-ET occurring between January 2008 and December 2013. The cases were examined via transvaginal ultrasonography (TVS). Embryonic tissue karyotyping following miscarriage was performed using a comparative genomic hybridization (CGH) analysis with fluorescence in situ hybridization (FISH)...
October 28, 2016: Journal of Assisted Reproduction and Genetics
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