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Early pregnancy loss

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https://www.readbyqxmd.com/read/28736365/-blighted-ovum-in-subfertile-patients-undergoing-assisted-reproductive-technology
#1
Qing-Wen Nie, Rui Hua, Yao Zhou, Hong Li, Yan-Hong Yu
OBJECTIVE: To explore the incidence and risk factors of blighted ovum in subfertile patients undergoing assisted reproductive technology (ART). METHODS: This retrospective analysis was conducted among 2378 patients who were pregnant following embryo transfer at our center from January, 2012 to December, 2015, including cases of early pregnancy losses and simultaneous live births. The cases with early pregnancy losses were divided into embryonic pregnancy and blighted ovum groups based on the presence or absence of an embryonic pole before dilation and curettage...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28736152/time-lapse-culture-with-morphokinetic-embryo-selection-improves-pregnancy-and-live-birth-chances-and-reduces-early-pregnancy-loss-a-meta-analysis
#2
REVIEW
Csaba Pribenszky, Anna-Maria Nilselid, Markus Montag
Embryo evaluation and selection is fundamental in clinical IVF. Time-lapse follow-up of embryo development comprises undisturbed culture and the application of the visual information to support embryo evaluation. A meta-analysis of randomized controlled trials was carried out to study whether time-lapse monitoring with the prospective use of a morphokinetic algorithm for selection of embryos improves overall clinical outcome (pregnancy, early pregnancy loss, stillbirth and live birth rate) compared with embryo selection based on single time-point morphology in IVF cycles...
July 10, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28727059/dynamics-of-nitrogen-retention-at-two-feeding-levels-in-gestating-parity-2-and-3-sows
#3
E G Miller, C L Levesque, N L Trottier, C F M de Lange
Parity-2 ( = 39) and -3 ( = 28; same sows from parity-2 sows) Yorkshire sows were used to measure whole body protein deposition (Pd) during gestation (maternal and pregnancy-associated) at 2 feeding levels to test the hypothesis that the pattern of whole body and maternal Pd during gestation does not differ when feeding either 15% above or 15% below estimated ME requirements, both exceeding AA requirements. Initial BW and backfat (BF) at d 26 ± 0.3 of gestation were 195.4 ± 5.2 kg and 15.1 ± 0.5 mm, and 223...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28718242/ectopic-pregnancy-with-tubal-rupture-an-analysis-of-80-cases
#4
Sana Ashfaq, Sadia Sultan, Safia Aziz, Marium Mohammed Irfan, Miray Hasan, Afshan Siddique
BACKGROUND: Ectopic pregnancy (EP) is a major problem in obstetrics as there is evidence of increasing incidence throughout the world. It is an important cause of maternal morbidity and mortality. In Pakistan, the care seeking behaviour among female is limited that makes female vulnerable to die due to complication of ectopic pregnancy. The aim of this study is to determine the frequency of tubal rupture in ectopic pregnancy in Pakistani patients. METHODS: In this crosssectional study data pertaining to age, gestational age, parity and duration of presenting symptoms were collected and analysed...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28713290/advanced-maternal-age-worsens-postpartum-vascular-function
#5
Jude S Morton, Alison S Care, Raven Kirschenman, Christy-Lynn Cooke, Sandra T Davidge
The age at which women experience their first pregnancy has increased throughout the decades. Pregnancy has an important influence on maternal short- and long-term cardiovascular outcomes. Pregnancy at an advanced maternal age increases maternal risk of gestational diabetes, preeclampsia, placenta previa and caesarian delivery; complications which predict worsened cardiovascular health in later years. Aging also independently increases the risk of cardiovascular disease; therefore, combined risk in women of advanced maternal age may lead to detrimental cardiovascular outcomes later in life...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28708531/relationships-among-early-postpartum-luteal-activity-parity-and-insemination-outcomes-based-on-in-line-milk-progesterone-profiles-in-canadian-holstein-cows
#6
Tony C Bruinjé, Marcos G Colazo, Mohanathas Gobikrushanth, Divakar J Ambrose
The objectives of this retrospective study were to use in-line milk progesterone (mP4) data to investigate relationships of (1) commencement of luteal activity (CLA), and (2) luteal phase (LP) length and frequency preceding first postpartum AI, with parity and AI outcomes in Canadian Holstein cows. Starting 21 ± 1 days postpartum (DPP), levels of mP4 were assessed every 2.2 ± 2.0 d through an automated in-line milk analysis system (Herd Navigator™, DeLaval International, Tumba, Sweden) until ∼55 d after first or second AI in 748 Holstein cows from two herds...
May 27, 2017: Theriogenology
https://www.readbyqxmd.com/read/28708529/maternal-and-non-maternal-factors-associated-with-late-embryonic-and-early-fetal-losses-in-dairy-cows
#7
Hany Abdalla, Adel Elghafghuf, Ibrahim Elsohaby, Mohammed A F Nasr
Defining factors associated with embryonic and/or fetal losses will be helpful in overcoming such problem, either by adjusting conditions or applying therapeutic approaches to high-risk cows. The objective of this study was to investigate the association between a number of maternal and non-maternal factors and the risk of late embryonic (LED) and early fetal death (EFD) in dairy herds. Additionally, we investigated the effect of treating pregnant cows either with GnRH on day 26 post-insemination, or GnRH on day 26 plus CIDR insertion between days 26 and 33 post-insemination, on the risk of LED/EFD...
April 4, 2017: Theriogenology
https://www.readbyqxmd.com/read/28705424/post-implantation-development-reveals-that-biopsy-procedure-can-segregate-healthy-from-unhealthy-bovine-embryos-and-prevent-miscarriages
#8
Clara Slade Oliveira, Carolina Capobiango Romano Quintão, Celio de Freitas, Agostinho Jorge Dos Reis Camargo, Raquel Varella Serapião, Luiz Sérgio de Almeida Camargo
Embryo biopsy has been performed in bovine in vivo produced embryos for the last twenty years, but little could be done with few embryonic cells in the past. Recently, advances in single cell analysis enabled a wide range of applications using embryo biopsy, from morphology to genetics analysis and different omics-techniques, which are promising for in vitro-fertilized (IVF) embryos. The aim of this study was to address if biopsy procedure would affect post implantation development of IVF blastocyts. Here we show that blastocyst stage do not affect re-expansion of biopsied embryos (regular blastocyst: 73...
June 29, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28672755/pregnancy-outcomes-among-patients-with-recurrent-pregnancy-loss-and-chromosomal-aberration-ca-without-pgd
#9
Maor Kabessa, Avi Harlev, Michael Friger, Ruslan Sergienko, Baila Litwak, Arie Koifman, Naama Steiner, Asher Bashiri
BACKGROUND: Recurrent pregnancy loss (RPL) is defined by two or more failed clinical pregnancies. Three to four percent of the couples with RPL have chromosomal aberrations (CA) in at least one partner. The parent's structural chromosomal abnormalities may cause an unbalanced karyotype in the conceptus which could lead to implantation failure, early or late pregnancy loss, or delivery of a child with severe physical and/or mental disabilities. OBJECTIVE: To compare live birth rates of couples with CA to couples with normal karyotypes and to investigate medical and obstetric characteristics and pregnancy outcomes of couples with CA and RPL who attend an RPL clinic at a tertiary hospital...
June 26, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28670836/epithelial-cadherin-disassociates-from-the-lateral-plasma-membrane-of-uterine-epithelial-cells-throughout-pregnancy-in-a-marsupial
#10
Jessica S Dudley, Christopher R Murphy, Michael B Thompson, Bronwyn M McAllan
The uterine luminal epithelium is the first site of contact between fetal and maternal tissues during therian pregnancy and must undergo specialised changes for implantation of the blastocyst to be successful. These changes, collectively termed the plasma membrane transformation (PMT), allow the blastocyst to attach to the uterine epithelium preceding the formation of a placenta. There are similarities in the morphological and molecular changes occurring in live-bearing eutherian species during the PMT studied so far...
July 3, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28666477/management-of-persistent-caesarean-scar-pregnancy-after-curettage-treatment-failure
#11
Zhi-Da Qian, Yue Weng, Yong-Jiang Du, Chun-Fen Wang, Li-Li Huang
BACKGROUND: Caesarean scar pregnancy (CSP) is a late serious complication of caesarean section. The incidence of CSP has increased worldwide in recent years. Early diagnosis and prompt therapy are crucial to avoid catastrophic complications. There are various strategies for CSP treatment, but there is no consensus on the best management for CSP. Dilation and curettage (D&C) and hysteroscopy are common and effective treatments with their advantages and disadvantages. No in-depth study of the clinical effects of hysteroscopic management of CSP after D&C treatment failure has been conducted...
July 1, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28662500/overview-of-chromosome-abnormalities-in-first-trimester-miscarriages-a-series-of-1-011-consecutive-chorionic-villi-sample-karyotypes
#12
Anna Soler, Carme Morales, Irene Mademont-Soler, Ester Margarit, Antoni Borrell, Virginia Borobio, Miriam Muñoz, Aurora Sánchez
In order to contribute to the knowledge of type and frequency of chromosome abnormalities in early pregnancy losses, we analyzed the cytogenetic results from a large series of first trimester miscarriages, using a diagnostic approach with a high success rate and no maternal contamination. A total of 1,119 consecutive chorionic villi samples were obtained before evacuation, and karyotypes were prepared after short-term culture (STC). In 603 samples, a long-term culture (LTC) was also performed. The overall and individual frequencies of the different types of chromosome abnormalities were established, including placental mosaicisms, and their relationship with maternal age and gestational weeks was assessed...
June 30, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28661560/pregnancy-and-spontaneous-fetal-loss-a-pig-perspective
#13
REVIEW
Mallikarjun Bidarimath, Chandrakant Tayade
Pigs have a unique, non-invasive epitheliochorial placenta where maternal and fetal layers lay in apposition. Indentation of fetal capillaries into the trophoblasts and maternal capillaries into the uterine epithelium reduce the distance between the fetal and maternal blood, ensuring nutrient transfer for proper conceptus development. Another unique feature of pig pregnancy is conceptus-mediated immune cell enrichment during the early stages of conceptus attachment (around gestation Day 15). This period coincides with the development of vasculature networks at the maternal-fetal interface, which is critical for successful conceptus growth...
June 29, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28660118/intervening-during-and-after-pregnancy-to-prevent-weight-retention-among-african-american-women
#14
Sharon J Herring, Jane F Cruice, Gary G Bennett, Niesha Darden, Jessica J Wallen, Marisa Z Rose, Adam Davey, Gary D Foster
Efforts to prevent postpartum weight retention in extant clinical trials of African American women have proven exceedingly challenging. The primary purpose of this pilot study was to determine whether a behavioral intervention implemented in early pregnancy through 6 months postpartum could increase the proportion of African American women who were at or below their early pregnancy weights by 6 months postpartum. We additionally evaluated whether mothers' postpartum weight loss could be maintained at 12 months postpartum...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28650773/a-successful-live-birth-with-in-vitro-fertilization-and-thawed-embryo-transfer-after-conservative-treatment-of-recurrent-endometrial-cancer
#15
Sung Woo Kim, Hoon Kim, Seung-Yup Ku, Chang Suk Suh, Seok Hyun Kim, Young Min Choi
Estrogen-dependent early stage endometrial cancer is relatively common in young women of reproductive age. The standard treatment is hysterectomy and bilateral salpingo-oophorectomy (BSO), even in early stage well-differentiated endometrial cancer patients. This surgical option results in permanent loss of fertility. There have been some reports of live births using in vitro fertilization after conservative management of endometrial cancer with high-dose progestin for the purpose of fertility preservation. However, most were not recurrent cases and pregnancy was achieved through conventional in vitro fertilization, which usually raises serum estradiol levels and may lead to the recurrence of endometrial cancer...
June 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28645640/communicating-to-promote-informed-decisions-in-the-context-of-early-pregnancy-loss
#16
Maria Brann, Jennifer J Bute
OBJECTIVE: To evaluate residents' ability to engage standardized patients in informed decision making during a pregnancy loss scenario. METHODS: Forty patient encounters between interns and standardized patients were coded to assess informed decision-making practices, exploration of unexpressed concerns, and support provision. RESULTS: Interns engaged in minimum informed decision making but did not address all of the communicative elements necessary for informed decisions, and most elements were only partially addressed...
June 17, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28630065/ccr5-is-involved-in-interruption-of-pregnancy-in-mice-infected-with-toxoplasma-gondii-during-early-pregnancy
#17
Maki Nishimura, Kousuke Umeda, Masayuki Suwa, Hidefumi Furuoka, Yoshifumi Nishikawa
Toxoplasmosis can cause abortion in pregnant humans and other animals; however, the mechanism of abortion remains unknown. C-C chemokine receptor type 5 (CCR5) is essential for host defense in T. gondii infection. To investigate the relationship between CCR5 and abortion in toxoplasmosis, we inoculated wild-type and CCR5-deficient (CCR5(-/-)) mice with T. gondii tachyzoites intraperitoneally on day 3 of pregnancy (E3). The pregnancy rate decreased as pregnancy progressed in the infected wild-type mice. Histopathologically, no inflammatory lesions were observed in the fetoplacental tissues...
June 19, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28629489/eating-down-or-simply-eating-less-the-diet-and-health-implications-of-these-practices-during-pregnancy-and-postpartum-in-rural-bangladesh
#18
Kassandra L Harding, Susana L Matias, Malay K Mridha, Stephen A Vosti, Sohrab Hussain, Kathryn G Dewey, Christine P Stewart
OBJECTIVE: To: (i) determine the prevalence of self-reported eating less and eating down during early and late pregnancy and postpartum, and explore risk factors associated with eating less; (ii) examine the association between eating less and diet quality; and (iii) determine the association between eating less and weight gain during pregnancy. DESIGN: Data were collected longitudinally from a cohort of women participating in a community health programme. Diet was assessed at three time points (≤20 weeks' gestation, 36 weeks' gestation, 6 months' postpartum), body weight was measured during study enrolment (≤20 weeks' gestation) and at 36 weeks' gestation, and information about the woman and her household was collected at enrolment...
June 20, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28621046/impact-of-borderline-subclinical-hypothyroidism-on-subsequent-pregnancy-outcome-in-women-with-unexplained-recurrent-pregnancy-loss
#19
Sayaka Uchida, Tetsuo Maruyama, Maki Kagami, Fumie Miki, Hanako Hihara, Satomi Katakura, Yushi Yoshimasa, Hirotaka Masuda, Hiroshi Uchida, Mamoru Tanaka
AIM: Because subclinical hypothyroidism (thyroid-stimulating hormone [TSH] > 4.5 IU/mL) is associated with adverse pregnancy outcome, including early pregnancy loss, TSH is recommended to be titrated to ≤2.5 mIU/L in levothyroxine-treated women before pregnancy. The purpose of this study was to determine whether borderline-subclinical hypothyroidism (borderline-SCH; 2.5 < TSH ≤ 4.5 IU/mL) affects the outcome of subsequent pregnancies in women with unexplained recurrent pregnancy loss (uRPL)...
June 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28601159/abnormal-pregnancies-associated-with-deviation-in-progestin-and-estrogen-profiles-in-late-pregnant-mares-a-diagnostic-aid
#20
Mitsumori Shikichi, Katsuroku Iwata, Katsumi Ito, Daisuke Miyakoshi, Harutaka Murase, Fumio Sato, Kenji Korosue, Shunichi Nagata, Yasuo Nambo
Measurement of progestines and estrogens in maternal plasma has been advocated as an indicator of foeto-placental function. The goals of the present study were as follows: to determine progestin and estrogen concentrations in mares with normal and abnormal pregnancies during late gestation, evaluate the diagnostic value of hormone concentrations, and investigate the relationship between hormone concentrations after treatment and the survival of foals. Blood samples were collected monthly from 459 pregnant mares between Day 201 of gestation and foaling...
August 2017: Theriogenology
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