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Early pregnancy loss

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https://www.readbyqxmd.com/read/29141364/-effects-of-combination-therapy-with-aspirin-prednisone-and-elevit-in-patients-with-unexplained-recurrent-early-pregnancy-loss
#1
H Ou, Q Yu
Objective: To investigate the effect of triple therapy with aspirin, prednisone and Elevit in patients with unexplained recurrent early pregnancy loss. Methods: From January 1, 2013 to December 31, 2016, a total of 353 women of childbearing age were enrolled in Peking Union Medical College Hospital, including blood, urine and vaginal swabs. One hundred and fifty-five patients were observed normal results of blood test, urine test and vaginal swabs. According to the treatment regimen, 155 patients were divided into two groups, 89 patients (57...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29138679/modulatory-mechanism-of-polyphenols-and-nrf2-signaling-pathway-in-lps-challenged-pregnancy-disorders
#2
REVIEW
Tarique Hussain, Bie Tan, Gang Liu, Ghulam Murtaza, Najma Rahu, Muhammad Saleem, Yulong Yin
Early embryonic loss and adverse birth outcomes are the major reproductive disorders that affect both human and animals. The LPS induces inflammation by interacting with robust cellular mechanism which was considered as a plethora of numerous reproductive disorders such as fetal resorption, preterm birth, teratogenicity, intrauterine growth restriction, abortion, neural tube defects, fetal demise, and skeletal development retardation. LPS-triggered overproduction of free radicals leads to oxidative stress which mediates inflammation via stimulation of NF-κB and PPARγ transcription factors...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29136014/treatment-guidelines-and-early-loss-from-care-for-people-living-with-hiv-in-cape-town-south-africa-a-retrospective-cohort-study
#3
Ingrid T Katz, Richard Kaplan, Garrett Fitzmaurice, Dominick Leone, David R Bangsberg, Linda-Gail Bekker, Catherine Orrell
BACKGROUND: South Africa has undergone multiple expansions in antiretroviral therapy (ART) eligibility from an initial CD4+ threshold of ≤200 cells/μl to providing ART for all people living with HIV (PLWH) as of September 2016. We evaluated the association of programmatic changes in ART eligibility with loss from care, both prior to ART initiation and within the first 16 weeks of starting treatment, during a period of programmatic expansion to ART treatment at CD4+ ≤ 350 cells/μl...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29119739/fertility-outcomes-in-infertile-women-with-complex-hyperplasia-or-complex-atypical-hyperplasia-who-received-progestin-therapy-and-in-vitro-fertilization
#4
Miao Li, Jia-Lun Song, Ying Zhao, She-Ling Wu, Hong-Bin Liu, Rong Tang, Lei Yan
This study aimed to evaluate fertility and oncologic outcomes in women with complex hyperplasia (CH) or complex atypical hyperplasia (CAH) who received fertility-sparing therapy and in vitro fertilization (IVF). Endometrial carcinoma is the most common carcinoma of the female genital tract, and is associated with endometrial hyperplasia (EH) resulting from long-term unopposed estrogenic stimulation of the endometrium. EH is characterized by non-physiological proliferation of endometrium that results in glands with irregular shapes and varying sizes...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29115663/endogenous-annexin-a1-anxa1-modulates-early-phase-gestation-and-offspring-sex-ratio-skewing
#5
Cristina Bichels Hebeda, Isabel Daufenback Machado, Isadora Reif-Silva, Jusciele Brogin Moreli, Sonia Maria Oliani, Suchita Nadkarni, Mauro Perretti, Estela Bevilacqua, Sandra H P Farsky
Annexin A1 (AnxA1) is a glucocorticoid-regulated anti-inflammatory protein secreted by phagocytes and other specialised cells. In the endocrine system, AnxA1 controls secretion of steroid hormones and it is abundantly expressed in the testis, ovaries, placenta and seminal fluid, yet its potential modulation of fertility has not been described. Here we observed that AnxA1 knockout (KO) mice delivered a higher number of pups, with a higher percentage of female offsprings. This profile was not dependent on the male features, as sperm from KO male mice did not present functional alterations, and had an equal proportion of Y and X chromosomes, comparable to wild type (WT) male mice...
November 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29115087/methylenetetrahydrofolate-reductase-polymorphisms-and-risk-of-recurrent-pregnancy-loss-a-case-control-study
#6
Kyu Ri Hwang, Young Min Choi, Jin Ju Kim, Sung Ki Lee, Kwang Moon Yang, Eun Chan Paik, Hyeon Jeong Jeong, Jong Kwan Jun, Sang Ho Yoon, Min A Hong
The balance between coagulation and fibrinolysis is an essential part in early pregnancy. Mutations in methylenetetrahydrofolate reductase (MTHFR) gene lead to decreased activity of the enzyme and hyperhomocysteinemia, which then induces platelet aggregation by promoting endothelial oxidative damage, possibly resulting in adverse effect on maintenance of pregnancy. We investigated the role of MTHFR single nucleotide polymorphisms (SNPs), C677T and A1298C, in Korean patients with recurrent pregnancy loss (RPL)...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29113580/prominin-2-prevents-the-formation-of-caveolae-in-normal-and-ovarian-hyperstimulated-pregnancy
#7
Samson N Dowland, Romanthi J Madawala, Connie E Poon, Laura A Lindsay, Christopher R Murphy
During early pregnancy, uterine epithelial cells (UECs) become less adherent to the underlying basal lamina and are subsequently removed so the blastocyst can invade the underlying stroma. This process involves the removal of focal adhesions from the basal plasma membrane of UECs. These focal adhesions are thought to be internalized by caveolae, which significantly increase in abundance at the time of blastocyst implantation. A recent in vitro study indicated that prominin-2 prevents the formation of caveolae by sequestering membrane cholesterol...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29110260/disparities-in-reproductive-outcomes-according-to-the-endometrial-preparation-protocol-in-frozen-embryo-transfer-the-risk-of-early-pregnancy-loss-in-frozen-embryo-transfer-cycles
#8
I Hatoum, L Bellon, N Swierkowski, M Ouazana, S Bouba, K Fathallah, B Paillusson, M Bailly, F Boitrelle, L Alter, M Bergère, J Selva, R Wainer
PURPOSE: The purpose of this study was to determine the effect of stimulated and artificial endometrial preparation protocols on reproductive outcomes in frozen embryo transfer (FET) cycles. METHODS: We performed a retrospective study of 1926 FET cycles over a 3.5-year period in the Fertility Unit at a University Hospital. Stimulated and artificial protocols were used for endometrial preparation. The embryos for FET were obtained from either in vitro fertilization or intracytoplasmic sperm injection cycles...
November 6, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29105384/hypoxic-stress-forces-adaptive-and-maladaptive-placental-stress-responses-in-early-pregnancy
#9
Yu Yang, Mohammed Abdulhasan, Awoniyi Awonuga, Alan Bolnick, Elizabeth E Puscheck, Daniel A Rappolee
This review focuses on hypoxic stress and its effects on the placental lineage and the earliest differentiation events in mouse and human placental trophoblast stem cells (TSCs). Although the placenta is a decidual organ at the end of pregnancy, its earliest rapid growth and function at the start of pregnancy precedes and supports growth and function of the embryo. Earliest function requires that TSCs differentiate, however, "hypoxia" supports rapid growth, but not differentiation of TSCs. Most of the literature on earliest placental "hypoxia" studies used 2% oxygen which is normoxic for TSCs...
October 16, 2017: Birth defects research
https://www.readbyqxmd.com/read/29102110/fetopathic-effects-of-experimental-schmallenberg-virus-infection-in-pregnant-goats
#10
Eve Laloy, Emmanuel Bréard, Sascha Trapp, Nathalie Pozzi, Mickaël Riou, Céline Barc, Sylvain Breton, Rémi Delaunay, Nathalie Cordonnier, Sophie Chateau-Joubert, Didier Crochet, Julie Gouzil, Typhaine Hébert, Maxime Raimbourg, Cyril Viarouge, Damien Vitour, Benoît Durand, Claire Ponsart, Stéphan Zientara
Schmallenberg virus (SBV) is an emerging virus responsible for congenital malformations in the offspring of domestic ruminants. It is speculated that infection of pregnant dams may also lead to a significant number of unrecognized fetal losses during the early period of gestation. To assess the pathogenic effects of SBV infection of goats in early pregnancy, we inoculated dams at day 28 or 42 of gestation and followed the animals until day 55 of gestation. Viremia in the absence of clinical signs was detected in all virus-inoculated goats...
November 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29097507/noninvasive-prenatal-diagnosis-of-single-gene-disorders-by-use-of-droplet-digital-pcr
#11
Joan Camunas-Soler, Hojae Lee, Louanne Hudgins, Susan R Hintz, Yair J Blumenfeld, Yasser Y El-Sayed, Stephen R Quake
BACKGROUND: Prenatal diagnosis in pregnancies at risk of single-gene disorders is currently performed using invasive methods such as chorionic villus sampling and amniocentesis. This is in contrast with screening for common aneuploidies, for which noninvasive methods with a single maternal blood sample have become standard clinical practice. METHODS: We developed a protocol for noninvasive prenatal diagnosis of inherited single-gene disorders using droplet digital PCR from circulating cell-free DNA (cfDNA) in maternal plasma...
November 2, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29096270/de-novo-synthesis-of-sphingolipids-is-essential-for-decidualization-in-mice
#12
Nai-Zheng Ding, Qian-Rong Qi, Xiao-Wei Gu, Ru-Juan Zuo, Jie Liu, Zeng-Ming Yang
Sphingolipids play multiple roles in membrane structure, signal transduction, stress responses, neural development and immune reaction. The rate of de novo synthesis pathway of sphingolipids is regulated by two key enzymes, serine palmitoyltransferase (SPT), and ketoreductase (Kds). Here, we find that the mRNA levels of three subunits of the SPT holoenzyme (Sptlc1, Sptlc2, and Ssspta) are significantly up-regulated in mouse uterine stromal cells during decidualization. The expression of Kds, which reduces 3-keto-dihydrosphingosine to dihydrosphingosine, is co-localized with Sptlc1 in mouse uteri during early pregnancy...
October 9, 2017: Theriogenology
https://www.readbyqxmd.com/read/29095179/barriers-to-research-recruitment-of-women-experiencing-a-pregnancy-loss-in-the-emergency-department
#13
Brittany E Punches, Kimberly D Johnson, Shauna P Acquavita, Dianne M Felblinger, Gordon L Gillespie
Women often come to the emergency department (ED) with signs and symptoms suggesting an early pregnancy loss; yet, little is known about their experience and how it relates to future outcomes. To improve patient outcomes and experiences of women seeking care for a pregnancy loss, research is required. However, recruitment of participants experiencing an event such as a pregnancy loss is challenging. The purpose of this article is to discuss the application of an electronic medical record (EMR)-based participant screening tool recruiting women seeking care for a pregnancy loss in the ED...
October 2017: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/29092905/estrogen-induces-egr1-to-fine-tune-its-actions-on-uterine-epithelium-by-controlling-pr-signaling-for-successful-embryo-implantation
#14
Hye-Ryun Kim, Yeon Sun Kim, Jung Ah Yoon, Seung Chel Yang, Mira Park, Dong-Won Seol, Sang Woo Lyu, Jin Hyun Jun, Hyunjung Jade Lim, Dong Ryul Lee, Haengseok Song
The harmonized actions of ovarian E2 and progesterone (P4) regulate the proliferation and differentiation of uterine cells in a spatiotemporal manner. Imbalances between these hormones often lead to infertility and gynecologic diseases. Whereas numerous factors that are involved in P4 signaling have been identified, few local factors that mediate E2 actions in the uterus have been revealed. Here, we demonstrate that estrogen induces the transcription factor, early growth response 1 (Egr1), to fine-tune its actions in uterine epithelial cells (ECs) that are responsible for uterine receptivity for embryo implantation...
November 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29090527/novel-pregnancy-triggered-episodes-of-capos-syndrome
#15
Irene J Chang, Margaret P Adam, Suman Jayadev, Thomas D Bird, Niranjana Natarajan, Ian A Glass
Cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss (CAPOS) syndrome (OMIM# 601338) is a rare autosomal dominant disorder characterized by episodic, fever-induced ataxic encephalopathy in childhood with residual symptoms. All identified patients have the same heterozygous missense variant c.2452G>A (p.Glu818Lys) in the ATP1A3 gene, encoding Na(+) /K(+) ATPase α3. We describe a large CAPOS pedigree with three generations of affected members, the first ascertained in the United States...
November 1, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29073542/pregnancy-diagnosis-in-cattle-using-pregnancy-associated-glycoprotein-concentration-in-circulation-at-day-24-of-gestation
#16
S T Reese, M H C Pereira, J L Edwards, J L M Vasconcelos, K G Pohler
Cattle producers are limited to day 28-30 of gestation as the earliest time point for accurate pregnancy diagnosis due to the effectiveness of ultrasound and chemical based methods, including commercially available pregnancy associated glycoproteins (PAG) tests. The objective of the current studies were to determine if early gestation circulating PAG concentrations at day 24 could be used to diagnose pregnancy in dairy cattle undergoing embryo transfer. In vitro produced embryos were transferred into Holstein x Gir cows and heifers on day 7 following ovulation...
October 12, 2017: Theriogenology
https://www.readbyqxmd.com/read/29056645/fertility-lost-fertility-found-narratives-from-the-leading-edge-of-oncofertility
#17
Teresa K Woodruff
A cancer diagnosis at a young age creates one of the most existential crises one can imagine. The good news is that for many of these young patients, they will survive their diagnosis. They will be told of the side effects of treatment including loss of hair but will not be told of the other losses associated with their reproductive function-loss of menstrual cycles, early menopause and the potential for pregnancy for women, loss of viable sperm for men, and loss of sexual libido in both cases. Not all cancer treatments result in the same series of fertility effects so one of the issues that physicians face is determining what the best course of fertility sparing options should be...
2017: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/29055063/added-value-of-chromosomal-microarray-analysis-cma-over-karyotyping-in-early-pregnancy-loss-a-systematic-review-and-meta-analysis
#18
REVIEW
Montse Pauta, Maribel Grande, Laia Rodriguez-Revenga, Elena Kolomietz, Antoni Borrell
OBJECTIVE: To perform a systematic review of the literature and meta-analysis to estimate the added value of chromosomal microarray analysis (CMA) over karyotyping in early pregnancy loss. METHOD: This was a systematic review conducted in accordance with PRISMA criteria. All articles identified in PubMed, Ovid Medline and Web of Science, from January 2000 to April 2017 describing copy number variants (CNVs) in early pregnancy losses (up to 20 weeks) were included...
October 21, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29053188/trends-in-risk-of-pregnancy-loss-among-us-women-1990-2011
#19
Lauren M Rossen, Katherine A Ahrens, Amy M Branum
BACKGROUND: Pregnancy loss can have physical and psychological consequences for women and their families. Though a previous study described an increase in the risk of self-reported pregnancy loss from 1970 to 2000, more recent examinations from population-based data of US women are lacking. METHODS: We used data from the 1995, 2002, 2006-2010, 2011-2015 National Survey of Family Growth on self-reported pregnancy loss (miscarriage, stillbirth, ectopic pregnancy) among US women (15-44 years) who reported at least one pregnancy conceived during 1990-2011 that did not result in induced termination (n = 20 012 women; n = 42 526 pregnancies)...
October 20, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29052319/from-pre-ovulatory-follicle-palpation-to-the-challenge-of-twin-pregnancies-clinical-reflections-following-one-million-gynaecological-examinations-in-dairy-cows
#20
REVIEW
F López-Gatius, R H F Hunter
Based on experimental studies and extensive field-scale experience, this review offers new proposals for: (i) elevating the success of modern insemination procedures, (ii) emphasizing features of a pre-ovulatory follicle in the context of optimum insemination timing, (iii) overcoming heat stress and its consequences using physiological processes or endocrine protocols, (iv) establishing a viable pregnancy or early pregnancy loss and (v) the challenge of twin pregnancies. In conclusion, the fertility of high-yielding dairy cows can be further improved...
October 2017: Reproduction in Domestic Animals, Zuchthygiene
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