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https://www.readbyqxmd.com/read/28431397/sensitization-of-tamoxifen-resistant-breast-cancer-cells-by-z-ligustilide-through-inhibiting-autophagy-and-accumulating-dna-damages
#1
Hongyi Qi, Zhuyun Jiang, Chengqiang Wang, Yi Yang, Li Li, Hui He, Zanyang Yu
Autophagy plays a pro-survival role in the tamoxifen-resistant breast cancer cells. Herein we found that autophagy was concomitantly induced in tamoxifen-resistant MCF-7 (MCF-7TR5) cells through the dissociation of Bcl-2 from Beclin 1 and subsequent enhancement of interaction among the ATG14-Beclin1-PI3KC3 complex. Moreover, higher level of DNA damage was observed in MCF-7TR5 cells with the decreased BRCA1 and RAD51 level and the increased Ku80 level. Interestingly, Nur77 was selectively degraded by autophagy, which causes the release of Ku80 from the Nur77-Ku80 complex, resulting in the increase of the DNA binding of Ku80 and DNA-PKcs...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430962/ulk1-prevents-cardiac-dysfunction-in-obesity-through-autophagy-meditated-regulation-of-lipid-metabolism
#2
Minae An, Dong-Ryeol Ryu, Jang Won Park, Ji Ha Choi, Eun-Mi Park, Kyung Eun Lee, Minna Woo, Minsuk Kim
Aims: Autophagy is essential to maintain tissue homeostasis, particularly in long-lived cells such as cardiomyocytes. Whereas many studies support the importance of autophagy in the mechanisms underlying obesity-related cardiac dysfunction, the role of autophagy in cardiac lipid metabolism remains unclear. In the heart, lipotoxicity is exacerbated by cardiac lipoprotein lipase (LPL), which mediates accumulation of fatty acids to the heart through intravascular triglyceride (TG) hydrolysis...
April 17, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28428343/mechanisms-of-autophagy-induction-by-sex-steroids-in-bovine-mammary-epithelial-cells
#3
Katarzyna Zielniok, Agnieszka Sobolewska, Malgorzata Gajewska
In dairy cattle mammary gland involution serves to remodel the secretory tissue, and occurs in a period of overlap between mammogenic stimulation caused by next developing pregnancy and tissue regression induced by milk stasis. At this time high concentrations of 17β-estradiol (E2) and progesterone (P4) support regeneration of the mammary tissue, as well as enhance autophagy, a cellular process induced in response to stressful conditions for energy generation and homeostasis maintenance. This study aimed to elucidate the mechanisms of autophagy induction by E2 and P4 using an in vitro model of involution based on 20-fold reduction of FBS content (from 10% to 0...
April 20, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28428083/the-roles-of-subcellularly-located-egfr-in-autophagy
#4
REVIEW
Hongsen Li, Liangkun You, Jiansheng Xie, Hongming Pan, Weidong Han
The epidermal growth factor receptor (EGFR) is a well-studied receptor-tyrosine kinase that serves vital roles in regulation of organ development and cancer progression. EGFR not only exists on the plasma membrane, but also widely expressed in the nucleus, endosomes, and mitochondria. Most recently, several lines of evidences indicated that autophagy is regulated by EGFR in kinase-active and -independent manners. In this review, we summarized recent advances in our understanding of the functions of different subcellularly located EGFR on autophagy...
April 18, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28427207/mir-205-inhibits-cell-growth-by-targeting-akt-mtor-signaling-in-progesterone-resistant-endometrial-cancer-ishikawa-cells
#5
Zhihong Zhuo, Huimin Yu
PURPOSE: miR-205 is significantly up-regulated in endometrioid adenocarcinoma. In this study, the significant anticancer effect of a miR-205 inhibitor was investigated in both endometrial carcinoma and progesterone-resistant endometrial carcinoma cells. RESULTS: Compared with Ishikawa endometrial cancer cells, miR-205 was expressed at higher levels in a progesterone-resistant (PR) sub-cell line. Inhibition of miR-205 suppressed the growth of cancer cells in a dose- and time-dependent manner...
March 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415610/the-tubulin-inhibitor-mg-2477-induces-autophagy-regulated-cell-death-ros-accumulation-and-activation-of-foxo3-in-neuroblastoma
#6
Judith Hagenbuchner, Lorena Lungkofler, Ursula Kiechl-Kohlendorfer, Giampietro Viola, Maria Grazia Ferlin, Michael J Ausserlechner, Petra Obexer
Neuroblastoma is the most frequent extra-cranial solid tumor in children with still high mortality in stage M. Here we studied the tubulin-inhibitor MG-2477 as a possible therapeutic agent for neuroblastoma therapy and uncovered that MG-2477 induces death in neuroblastoma cells independent of PKB-activation status and stage. MG-2477 triggers within 30 minutes extensive autophagosome-formation that finally leads to cell death associated with mitotic catastrophe. Autophagy is critical for MG-2477-induced death and is regulated by the BH3-only protein PMAIP1/NOXA which sequesters the anti-apoptotic BCL2-protein BCLXL and thereby displaces and activates the autophagy-regulator BECN1/beclin1...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28407698/spermidine-coupled-with-exercise-rescues-skeletal-muscle-atrophy-from-d-gal-induced-aging-rats-through-enhanced-autophagy-and-reduced-apoptosis-via-ampk-foxo3a-signal-pathway
#7
Jingjing Fan, Xiaoqi Yang, Jie Li, Ziyang Shu, Jun Dai, Xingran Liu, Biao Li, Shaohui Jia, Xianjuan Kou, Yi Yang, Ning Chen
The quality control of skeletal muscle is a continuous requirement throughout the lifetime, although its functions and quality present as a declining trend during aging process. Dysfunctional or deficient autophagy and excessive apoptosis may contribute to the atrophy of senescent skeletal muscle. Spermidine, as a natural polyamine, can be involved in important cellular functions for lifespan extension and stress resistance in several model organisms through activating autophagy. Similarly, cellular autophagic responses to exercise have also been extensively investigated...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28382029/probiotic-bacillus-amyloliquefaciens-sc06-induces-autophagy-to-protect-against-pathogens-in-macrophages
#8
Yanping Wu, Yang Wang, Hai Zou, Baikui Wang, Qiming Sun, Aikun Fu, Yuanyuan Wang, Yibing Wang, Xiaogang Xu, Weifen Li
Probiotics are increasingly applied in popularity in both humans and animals. Decades of research has revealed their beneficial effects, including the immune modulation in intestinal pathogens inhibition. Autophagy-a cellular process that involves the delivery of cytoplasmic proteins and organelles to the lysosome for degradation and recirculation-is essential to protect cells against bacterial pathogens. However, the mechanism of probiotics-mediated autophagy and its role in the elimination of pathogens are still unknown...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28377355/-role-of-beclin-1-gene-in-autophagy-and-apoptosis-of-sw620-cells
#9
Meng Lv, Hang Lu
OBJECTIVE: To study the role of Beclin1 gene in autophagy and apoptosis of SW620 cells. METHODS: RNA interference was used to knockdown the expression of Beclin 1 in SW620 cells, and the cell viability was measured by MTT assays. The autophagic activity in serum-starved SW620 CRC cells was evaluated by assessing endogenous microtubule-associated protein 1 light chain 3 (LC3) protein levels using immunofluorescence assay. Flow cytometry was used to measure the apoptosis rate of SW620 cells treated with serum deprivation, staurosporine or etoposide, and the protein expression of Beclin1 was detected using Western blotting...
March 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28374506/g-csf-and-cognitive-dysfunction-in-elderly-diabetic-mice-with-cerebral-small-vessel-disease-preventive-intervention-effects-and-underlying-mechanisms
#10
Zhu-Fei Guan, Ying-Hong Tao, Xiao-Ming Zhang, Qi-Lin Guo, Ying-Chao Liu, Yu Zhang, Yan-Mei Wang, Gang Ji, Guo-Feng Wu, Na-Na Wang, Hao Yang, Zhong-Yu Yu, Jing-Chun Guo, Hou-Guang Zhou
AIMS: Although cognitive dysfunction is a common neurological complication in elderly patients with diabetes, the mechanisms underlying this relationship remain unclear, and effective preventive interventions have yet to be developed. Thus, this study investigated the preventive effects and mechanisms of action associated with granulocyte colony-stimulating factor (G-CSF) on cognitive dysfunction in elderly diabetic mice with cerebral small vessel disease. METHODS: This study included 40 male db/db diabetic and wild-type (WT) mice that were categorized into the following four groups at the age of 3 weeks: db/db group (DG), db/db+G-CSF group (DGG), WT group (WG), and WT+G-CSF group (WGG)...
April 4, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28368777/pink1-and-becn1-relocalize-at-mitochondria-associated-membranes-during-mitophagy-and-promote-er-mitochondria-tethering-and-autophagosome-formation
#11
Vania Gelmetti, Priscilla De Rosa, Liliana Torosantucci, Elettra Sara Marini, Alessandra Romagnoli, Martina Di Rienzo, Giuseppe Arena, Domenico Vignone, Gian Maria Fimia, Enza Maria Valente
Mitophagy is a highly specialized process to remove dysfunctional or superfluous mitochondria through the macroautophagy/autophagy pathway, aimed at protecting cells from the damage of disordered mitochondrial metabolism and apoptosis induction. PINK1, a neuroprotective protein mutated in autosomal recessive Parkinson disease, has been implicated in the activation of mitophagy by selectively accumulating on depolarized mitochondria, and promoting PARK2/Parkin translocation to them. While these steps have been characterized in depth, less is known about the process and site of autophagosome formation upon mitophagic stimuli...
April 3, 2017: Autophagy
https://www.readbyqxmd.com/read/28356270/ulk1-mediated-autophagy-plays-an-essential-role-in-mitochondrial-remodeling-and-functional-regeneration-of-skeletal-muscle
#12
Jarrod A Call, Rebecca J Wilson, Rhianna C Laker, Mei Zhang, Mondira Kundu, Zhen Yan
Autophagy is a conserved cellular process for degrading aggregate proteins and dysfunctional organelle. It is still debatable if autophagy and mitophagy (a specific process of autophagy of mitochondria) play important roles in myogenic differentiation and functional regeneration of skeletal muscle. We tested the hypothesis that autophagy is critical for functional regeneration of skeletal muscle. We first observed time-dependent increases (3-6 fold) of autophagy-related proteins (Atgs), including Ulk1, Beclin1 and LC3, along with reduced p62 expression during C2C12 differentiation, suggesting increased autophagy capacity and flux during myogenic differentiation...
March 29, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28351336/b-cell-lymphoma-2-inhibitor-abt-737-induces-beclin1-and-reactive-oxygen-species-dependent-autophagy-in-adriamycin-resistant-human-hepatocellular-carcinoma-cells
#13
Xiaoxiao Yao, Xiaoning Li, Dan Zhang, Yingjun Xie, Baozhen Sun, Hang Li, Liankun Sun, Xuewen Zhang
ABT-737, a B-cell lymphoma 2 homology 3 mimetic, not only induces cell apoptosis by inhibiting the interaction of B-cell lymphoma 2 and Bax but also induces cell autophagy by interrupting the interaction of B-cell lymphoma 2 and Beclin1. Several recent studies have reported that ABT-737 has antitumor efficacy in diverse cancers. However, another study showed that hepatocellular carcinoma cells with high B-cell lymphoma 2 expression were resistant to ABT-737 compared to hepatocellular carcinoma cells with low B-cell lymphoma 2 expression...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28351322/pvt1-affects-growth-of-glioma-microvascular-endothelial-cells-by-negatively-regulating-mir-186
#14
Yawen Ma, Ping Wang, Yixue Xue, Chengbin Qu, Jian Zheng, Xiaobai Liu, Jun Ma, Yunhui Liu
Vigorous angiogenesis is one of the reasons for the poor prognosis of glioma. A number of studies have shown that long non-coding RNA can affect a variety of biological behaviors of tumors. However, the influence of long non-coding RNAs on glioma vascular endothelial cells remains unclear. To simulate the glioma microenvironment, we applied glioma-conditioned medium to human cerebral microvascular endothelial cells. The long non-coding RNA PVT1 was found to be highly expressed in glioma vascular endothelial cells...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28349379/ulva-pertusa-lectin-1-delivery-through-adenovirus-vector-affects-multiple-signaling-pathways-in-cancer-cells
#15
Gongchu Li, Zhenzhen Zhao, Bingbing Wu, Qunshu Su, Liqin Wu, Xinyan Yang, Jing Chen
Ulva pertusa lectin 1 (UPL1) is a N-acetyl-D-glucosamine (GlcNAc) binding lectin in marine green alga Ulva pertusa. Exogenous UPL1 colocalized with protein arginine methyltransferase 5 (PRMT5), methylosome protein 50 (MEP50), β-actin and β-tubulin, indicating the interaction of UPL1 with the methylosome and cytoskeleton. UPL1 delivery through adenovirus vector (Ad-UPL1) dramatically induced extracellularly regulated protein kinases 1/2 (ERK1/2) phosphorylation in liver cancer cell lines BEL-7404 and Huh7...
March 27, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28348069/hif-1%C3%AE-promotes-cells-migration-and-invasion-by-upregulating-autophagy-in-endometriosis
#16
Hengwei Liu, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Yao Xiong, Na Li, Haitang He, Yu Du, Yi Liu
Endometriosis is a benign gynaecological disease which shares some characteristics with malignancy like migration and invasion. It has been reported that both Hypoxia-Inducible Factor-1α (HIF-1α) and autophagy were upregulated in ectopic endometrium of patients with ovarian endometriosis. However, the crosstalk between HIF-1α and autophagy in the pathogenesis of endometriosis remains to be clarified. Accordingly, we investigated whether autophagy was regulated by HIF-1α, as well as whether the effect of HIF-1α on cell migration and invasion is mediated through autophagy upregulation...
March 27, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28345663/nuclear-localization-of-beclin-1-promotes-radiation-induced-dna-damage-repair-independent-of-autophagy
#17
Fei Xu, Yixuan Fang, Lili Yan, Lan Xu, Suping Zhang, Yan Cao, Li Xu, Xiaoying Zhang, Jialing Xie, Gaoyue Jiang, Chaorong Ge, Ni An, Daohong Zhou, Na Yuan, Jianrong Wang
Beclin 1 is a well-established core mammalian autophagy protein that is embryonically indispensable and has been presumed to suppress oncogenesis via an autophagy-mediated mechanism. Here, we show that Beclin 1 is a prenatal primary cytoplasmic protein but rapidly relocated into the nucleus during postnatal development in mice. Surprisingly, deletion of beclin1 in in vitro human cells did not block an autophagy response, but attenuated the expression of several DNA double-strand break (DSB) repair proteins and formation of repair complexes, and reduced an ability to repair DNA in the cells exposed to ionizing radiation (IR)...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28338195/tgf-%C3%AE-1-promotes-human-gastric-carcinoma-sgc7901-cells-invasion-by-inducing-autophagy
#18
J Shen, D-S Zhao, M-Z Li
OBJECTIVE: To investigate the role of TGF-b1 in autophagy and invasion ability in human gastric carcinoma cell line SGC7901. MATERIALS AND METHODS: Cultured SGC7901 cells were treated with different concentrations of TGF-b1 for 24 h. The protein expression levels of autophagy relative marker LC3 and Beclin1 were detected by Western blot. The effect of TGF-b1 on invasion ability of SGC7901 cells was detected with transwell method. RESULTS: The results demonstrated that TGF-b1 was able to induced autophagy of SGC7901 cells in a dose-dependent manner...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28337557/mir-9-enhances-the-sensitivity-of-a549-cells-to-cisplatin-by-inhibiting-autophagy
#19
Yan Zhang, Xia Meng, Cheng Li, Zhoulin Tan, Xinwei Guo, Zhiting Zhang, Tao Xi
OBJECTIVES: To demonstrate that miR-9 inhibits autophagy by down-regulating Beclin1 and thus enhances the sensitivity of A549 cells to cisplatin. RESULTS: MiR-9 inhibited Beclin1 expression by binding to its 3'UTR. The inhibition decreased the cisplatin-induced autophagy in A549 cells, evidenced by the decreased expression of LC3II and GFP-LC3 puncta and the increased expression of P62. Upregulation of miR-9 level enhanced the sensibility of A549 cells to cisplatin and increased the cisplatin-induced apoptosis...
March 23, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28320092/inhibition-of-pi3k-akt-mtor-signaling-pathway-promotes-autophagy-of-articular-chondrocytes-and-attenuates-inflammatory-response-in-rats-with-osteoarthritis
#20
Jian-Feng Xue, Zhong-Min Shi, Jian Zou, Xiao-Lin Li
OBJECTIVE: This study aims to explore the relationship between PI3K/AKT/mTOR signaling pathway and autophagy of articular chondrocytes in rats with osteoarthritis (OA). METHODS: Rat articular chondrocytes were isolated and cultured, and then induced by protein inhibitors of PI3K/AKT/mTOR signaling pathway. Chondrocytes were assigned into blank group, IL-1β induction group (IL-1β group), PI3K inhibitor+IL-1β induction group (PI3Ki+IL-1β group), AKT inhibitor+IL-1β induction group (AKTi+IL-1β group) and mTOR inhibitor+IL-1β induction group (mTORi+IL-1β group)...
March 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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