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https://www.readbyqxmd.com/read/28102107/occupational-dietary-and-other-risk-factors-for-myelodysplastic-syndromes-in-western-greece
#1
Christina Avgerinou, Ioanna Giannezi, Stela Theodoropoulou, Vasileios Lazaris, Georgia Kolliopoulou, Panagiotis Zikos, Yannis Alamanos, Michalis Leotsinidis, Argiris Symeonidis
PURPOSE: We have observed an increasing incidence of myelodysplastic syndromes (MDS) in the geographic area of Western Greece during the past two decades. The objective of this study was to investigate potential risk factors for the manifestation of MDS in this area of Greece. METHODS: A hospital-based case-control study was conducted in the public hospitals of the region. Participants were interviewed based on a questionnaire regarding demographics, occupational exposures, smoking, alcohol consumption, dietary, and domestic factors...
January 19, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28090784/effect-of-resveratrol-and-tetracycline-on-the-subacute-paraquat-toxicity-in-mice
#2
R M Satpute, P P Pawar, S Puttewar, S D Sawale, P D Ambhore
Paraquat (PQ) is a nonselective bipyridyl herbicide widely used in agriculture to control weeds, but its accidental, occupational, or intentional exposure in humans is known to cause pneumo- and neurotoxicity which may proves fatal. Oxidative stress is reported as an underlined mechanism of PQ-induced toxicity in alveolar cells, neurons, and astroglia. PQ generates superoxides both through electron transport reaction (ETC) with nicotinamide adenine dinucleotide-dependent oxidoreductase and by the redox cycling via reaction with molecular oxygen...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28088492/pikuni-blackfeet-traditional-medicine-neuroprotective-activities-of-medicinal-plants-used-to-treat-parkinson-s-disease-related-symptoms
#3
Aurélie de Rus Jacquet, Mitali Arun Tambe, Sin Ying Ma, George P McCabe, Jay Hansford C Vest, Jean-Christophe Rochet
ETHNOPHARMACOLOGICAL RELEVANCE: Parkinson's disease (PD) is a multifactorial neurodegenerative disorder affecting 5% of the population over the age of 85 years. Current treatments primarily involve dopamine replacement therapy, which leads to temporary relief of motor symptoms but fails to slow the underlying neurodegeneration. Thus, there is a need for safe PD therapies with neuroprotective activity. In this study, we analyzed contemporary herbal medicinal practices used by members of the Pikuni-Blackfeet tribe from Western Montana to treat PD-related symptoms, in an effort to identify medicinal plants that are affordable to traditional communities and accessible to larger populations...
January 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28077425/metastasis-suppressor-nm23-limits-oxidative-stress-in-mammals-by-preventing-activation-of-stress-activated-protein-kinases-jnks-through-its-nucleoside-diphosphate-kinase-activity
#4
Evelyne Peuchant, Marie-Lise Bats, Isabelle Moranvillier, Michel Lepoivre, Jérôme Guitton, Dominique Wendum, Marie-Lise Lacombe, François Moreau-Gaudry, Mathieu Boissan, Sandrine Dabernat
NME1 (nonmetastatic expressed 1) gene, which encodes nucleoside diphosphate kinase (NDPK) A [also known as nonmetastatic clone 23 (NM23)-H1 in human and NM23-M1 in mouse], is a suppressor of metastasis, but several lines of evidence-mostly from plants-also implicate it in the regulation of the oxidative stress response. Here, our aim was to investigate the physiologic relevance of NDPK A with respect to the oxidative stress response in mammals and to study its molecular basis. NME1 knockout mice died sooner, suffered greater hepatocyte injury, and had lower superoxide dismutase activity than did wild-type (WT) mice in response to paraquat-induced acute oxidative stress...
January 11, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28070046/-dose-effect-relationship-between-vitamin-c-and%C3%A2-paraquat-poisoning-rats
#5
Baoling Wen, Lei Yu, Yan Fang, Xiaolong Wang
To explore the dose-effect relationship between vitamin C and paraquat (PQ) poisoning rats.
 Methods: A total of 40 Sprague-Dawley (SD) rats were randomly divided into 4 groups: a control group, a PQ poisoning group, a vitamin C group 1 and a vitamin C group 2 (n=10 in each group). 150 mg/kg PQ was perfused into rat stomach to establish PQ poisoning rat model. In PQ poisoning group, 30 mg/kg methylprednisolone and 2.5 mg/kg cyclophosphamide were injected peritoneally on the basis of PQ poisoning rat model...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28057904/a-serine-threonine-phosphatase-1-of-streptococcus-suis-type-2-is-an-important-virulence-factor
#6
Lihua Fang, Pengcheng Fan, Yunkai Yang, Jingjing Zhou, Hongxia Shen, Weihuan Fang
Streptococcus suis is regarded as one of the major pathogens of pigs while S. suis type 2 (SS2) is considered to be a zoonotic bacterium for its ability to cause meningitis and streptococcal toxic shock-like syndrome in humans. Many bacterial species contain genes encoding serine/threonine protein phosphatases (STP) responsible for dephosphorylation of their substrates in a single reaction step. This study was aimed to investigate the role of stp1 in pathogenesis of SS2. An isogenic stp1 mutant (Δstp1) was constructed from the SS2 strain ZJ081101...
January 4, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28052447/a-multiresponsive-amphiphilic-supramolecular-diblock-copolymer-based-on-pillar-10-arene-paraquat-complexation-for-rate-tunable-controlled-release
#7
Xiaodong Chi, Xiaofan Ji, Li Shao, Feihe Huang
Herein, for rate-tunable controlled release, the authors report a new facile method to prepare multiresponsive amphiphilic supramolecular diblock copolymers via the cooperative complexation between a water-soluble pillar[10]arene and paraquat-containing polymers in water. This supramolecular diblock copolymer can self-assemble into multiresponsive polymeric micelles at room temperature in water. The resultant micelles can be further used in the controlled release of small molecules with tunable release rates depending on the type of single stimulus and the combination of various stimuli...
January 3, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28043264/-the-effects-of-p-glycoprotein-expression-induced-by-ulinastatin-on-hk-2-cells-damage-induced-by-paraquat
#8
X R She, X Tian, X K Fan, G L Hong, G J Zhao, M F Li, Z Q Lu
Objective: To investigate the protective effect of P-glycoprotein up-regulated by ulinastatin (UTI) on HK-2 cells during paraquat (PQ) -induced injury and its underlying mechanisms. Methods: The re- search was divided into two parts. The first part of the research was divided into normal control group, PQ group, UTI+PQ group, UTI control group. The second part of the research was divided into negative virus group (including control group, PQ group, PQU+TI group, UTI group) and P-gp siRNA group (including control group, PQ group, PQU+TI group, UTI group) ...
November 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28043053/the-decay-of-redox-stress-response-capacity-is-a-substantive-characteristic-of-aging-revising-the-redox-theory-of-aging
#9
Jiao Meng, Zhenyu Lv, Xinhua Qiao, Xiaopeng Li, Yazi Li, Yuying Zhang, Chang Chen
Aging is tightly associated with redox events. The free radical theory of aging indicates that redox imbalance may be an important factor in the aging process. Most studies about redox and aging focused on the static status of oxidative stress levels, there has been little research investigating differential responses to redox challenge during aging. In this study, we used Caenorhabditis elegans and human fibroblasts as models to compare differential responses to oxidative stress challenge in young and old individuals...
December 28, 2016: Redox Biology
https://www.readbyqxmd.com/read/28041945/knockdown-transgenic-lrrk-drosophila-resists-paraquat-induced-locomotor-impairment-and-neurodegeneration-a-therapeutic-strategy-for-parkinson-s-disease
#10
Diana Quintero-Espinosa, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo
Leucine-rich repeat kinase 2 (LRRK2) has been linked to familial and sporadic Parkinson's disease. However, it is still unresolved whether LRRK2 in dopaminergic (DAergic) neurons may or may not aggravate the phenotype. We demonstrate that knocking down (KD) the Lrrk gene by RNAi in DAergic neurons untreated or treated with paraquat (PQ) neither affected the number of DAergic clusters, tyrosine hydroxylase (TH) protein levels, lifespan nor locomotor activity when compared to control (i.e. TH/+) flies. KD transgenic Lrrk flies dramatically increased locomotor activity in presence of TH enzyme inhibitor alpha-methyl-para-tyrosine (aMT), whereas no effect on lifespan was observed in both fly lines...
December 29, 2016: Brain Research
https://www.readbyqxmd.com/read/28038352/effects-of-decreased-dopamine-transporter-levels-on-nigrostriatal-neurons-and-paraquat-maneb-toxicity-in-mice
#11
Franziska Richter, Lauryn Gabby, Kimberly A McDowell, Caitlyn K Mulligan, Krystal De La Rosa, Pedrom C Sioshansi, Farzad Mortazavi, Ingrid Cely, Larry C Ackerson, Linda Tsan, Niall P Murphy, Nigel T Maidment, Marie-Françoise Chesselet
How genetic variations in the dopamine transporter (DAT) combined with exposure to environmental toxins modulate the risk of Parkinson's disease remains unclear. Using unbiased stereology in DAT knock-down mice (DAT-KD) and wild-type (WT) littermates, we found that decreased DAT caused a loss of tyrosine hydroxylase-positive (dopaminergic) neurons in subregions of the substantia nigra pars compacta at 3-4 days, 5 weeks, and 18 months of age. Both genotypes lost dopaminergic neurons with age and remaining neurons at 11 months were resilient to paraquat/maneb...
December 1, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/28025881/probing-the-role-of-glycol-chain-lengths-in-%C3%AF-donor-acceptor-2-pseudorotaxanes-based-on-monopyrrolo-tetrathiafulvalene-and-cyclobis-paraquat-p-phenylene
#12
Rikke Kristensen, Sissel S Andersen, Gunnar Olsen, Jan O Jeppesen
We have investigated and quantified the role that the glycol chain length has on the strength of the noncovalent bonding interactions taking place between cyclobis(paraquat-p-phenylene) (CBPQT(4+)) and five different monopyrrolo-tetrathiafulvalene (MPTTF) derivatives that only differ in the length of the N-substituted glycol chain. The MPTTF derivatives were used to form [2]pseudorotaxanes by mixing them with CBPQT(4+). The binding constants (Ka) associated with the complexation process leading to the formation of the [2]pseudorotaxanes were obtained using the UV-vis-NIR dilution method and the [2]pseudorotaxanes were characterized structurally using (1)H NMR spectroscopy...
January 13, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28025796/ifn-%C3%AE-regulates-xanthine-oxidase-mediated-inos-independent-oxidative-stress-in-maneb-and-paraquat-treated-rat-polymorphonuclear-leukocytes
#13
Deepali Singh, Vinod Kumar, Chetna Singh
Maneb (MB) and paraquat (PQ) provoke oxidative stress-mediated cell damage. Role of xanthine oxidase (XO) in oxidative stress and its association with nitric oxide (NO)/NO synthase (NOS) have been widely reported. While inducible NOS (iNOS) is implicated in MB+PQ-induced toxicity in rat polymorphonuclear leukocytes (PMNs), role of XO and its alliance with iNOS have not yet been established. The study investigated the role of XO in MB+PQ-induced oxidative stress in rat PMNs and its regulation by iNOS and inflammatory cytokines...
December 26, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28017568/integration-of-the-free-liquid-membrane-into-electrokinetic-supercharging-capillary-electrophoresis-for-the-determination-of-cationic-herbicides-in-environmental-water-samples
#14
Mei Qi Chui, Lee Yien Thang, Hong Heng See
A new approach based on the integration of the free liquid membrane (FLM) into electrokinetic supercharging (EKS) was demonstrated to be a new powerful tool used in order to enhance online preconcentration efficiency in capillary electrophoresis (CE). A small plug of water immiscible organic solvent was used as a membrane interface during the electrokinetic sample injection step in EKS in order to significantly enhance the analyte stacking efficiency. The new online preconcentration strategy was evaluated for the determination of paraquat and diquat present in the environmental water samples...
December 15, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28012437/autophagy-deficient-keratinocytes-display-increased-dna-damage-senescence-and-aberrant-lipid-composition-after-oxidative-stress-in-vitro-and-in-vivo
#15
Xiuzu Song, Marie Sophie Narzt, Ionela Mariana Nagelreiter, Philipp Hohensinner, Lucia Terlecki-Zaniewicz, Erwin Tschachler, Johannes Grillari, Florian Gruber
Autophagy allows cells fundamental adaptations to metabolic needs and to stress. Using autophagic bulk degradation cells can clear crosslinked macromolecules and damaged organelles that arise under redox stress. Accumulation of such debris results in cellular dysfunction and is observed in aged tissue and senescent cells. Conversely, promising anti-aging strategies aim at inhibiting the mTOR pathway and thereby activating autophagy, to counteract aging associated damage. We have inactivated autophagy related 7 (Atg7), an essential autophagy gene, in murine keratinocytes (KC) and have found in an earlier study that this resulted in increased baseline oxidative stress and reduced capacity to degrade crosslinked proteins after oxidative ultraviolet stress...
December 18, 2016: Redox Biology
https://www.readbyqxmd.com/read/27993944/effects-of-airborne-toxicants-on-pulmonary-function-and-mitochondrial-dna-damage-in-rodent-lungs
#16
William L Rumsey, Brian Bolognese, Alicia B Davis, Pearl L Flamberg, Joseph P Foley, Steven R Katchur, Charles J Kotzer, Ruth R Osborn, Patricia L Podolin
Inhalation of airborne toxicants such as cigarette smoke and ozone is a shared health risk among the world's populations. The use of toxic herbicides like paraquat (PQ) is restricted by many countries, yet in the developing world PQ has demonstrable ill effects. The present study examined changes in pulmonary function, mitochondrial DNA (mtDNA) integrity and markers of DNA repair induced by acute or repeated exposure of PQ to rats. Similar to cigarette smoke and ozone, PQ promotes oxidative stress, and the impact of PQ on mtDNA was compared with that obtained with these agents...
December 18, 2016: Mutagenesis
https://www.readbyqxmd.com/read/27992185/rational-tuning-of-superoxide-sensitivity-in-soxr-the-2fe-2s-transcription-factor-implications-of-species-specific-lysine-residues
#17
Mayu Fujikawa, Kazuo Kobayashi, Yuko Tsutsui, Takahiro Tanaka, Takahiro Kozawa
In Escherichia coli, the [2Fe-2S] transcriptional factor, SoxR, functions as a sensor of oxidative stress. The transcriptional activity in SoxR is regulated by the reversible oxidation and reduction of [2Fe-2S] clusters. We previously proposed that superoxide (O2(•-)) has a direct role as a signal for E. coli SoxR and that the sensitivity of the E. coli SoxR response to O2(•-) is 10-fold higher than that of Pseudomonas aeruginosa SoxR. The difference between the two homologues reflects interspecies differences in the regulatory role of O2(•-) activation...
January 4, 2017: Biochemistry
https://www.readbyqxmd.com/read/27984170/autism-genes-are-selectively-targeted-by-environmental-pollutants-including-pesticides-heavy-metals-bisphenol-a-phthalates-and-many-others-in-food-cosmetics-or-household-products
#18
REVIEW
C J Carter, R A Blizard
The increasing incidence of autism suggests a major environmental influence. Epidemiology has implicated many candidates and genetics many susceptibility genes. Gene/environment interactions in autism were analysed using 206 autism susceptibility genes (ASG's) from the Autworks database to interrogate ∼1 million chemical/gene interactions in the comparative toxicogenomics database. Any bias towards ASG's was statistically determined for each chemical. Many suspect compounds identified in epidemiology, including tetrachlorodibenzodioxin, pesticides, particulate matter, benzo(a)pyrene, heavy metals, valproate, acetaminophen, SSRI's, cocaine, bisphenol A, phthalates, polyhalogenated biphenyls, flame retardants, diesel constituents, terbutaline and oxytocin, inter alia showed a significant degree of bias towards ASG's, as did relevant endogenous agents (retinoids, sex steroids, thyroxine, melatonin, folate, dopamine, serotonin)...
October 27, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27966490/ayurvedic-amalaki-rasayana-promotes-improved-stress-tolerance-and-thus-has-anti-aging-effects-in-drosophila-melanogaster
#19
Vibha Dwivedi, Subhash C Lakhotia
Amalaki Rasayana (AR) is a common Ayurvedic herbal formulation of Phyllanthus emblica fruits and some other ingredients, and is used for general good health and healthy aging. We reported it to improve life history traits and to suppress neurodegeneration as well as induced apoptosis in Drosophila. The present study examines responses of Drosophila reared on AR-supplemented food to crowding, thermal or oxidative stresses. Wild-type larvae/flies reared on AR-supplemented food survived the various cell stresses much better than those reared on control food...
December 2016: Journal of Biosciences
https://www.readbyqxmd.com/read/27957793/vascular-endothelial-growth-factor-d-modulates-oxidant-antioxidant-balance-of-human-vascular-endothelial-cells
#20
Izabela Papiewska-Pająk, Aneta Balcerczyk, Emilia Stec-Martyna, Wiktor Koziołkiewicz, Joanna Boncela
Vascular endothelial growth factor-D (VEGF-D) is an angiogenic and lymphangiogenic glycoprotein that facilitates tumour growth and distant organ metastasis. Our previous studies showed that VEGF-D stimulates the expression of proteins involved in cell-matrix interactions and promoting the migration of endothelial cells. In this study, we focused on the redox homoeostasis of endothelial cells, which is significantly altered in the process of tumour angiogenesis. Our analysis revealed up-regulated expression of proteins that form the antioxidant barrier of the cell in VEGF-D-treated human umbilical endothelial cells and increased production of reactive oxygen and nitrogen species in addition to a transient elevation in the total thiol group content...
December 13, 2016: Journal of Cellular and Molecular Medicine
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