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https://www.readbyqxmd.com/read/29143231/correction-to-combination-therapy-with-pirfenidone-plus-prednisolone-ameliorates-paraquat-induced-pulmonary-fibrosis
#1
Rokhsana Rasooli, Fatemeh Pourgholamhosein, Younes Kamali, Fatemeh Nabipour, Ali Mandegary
Unfortunately, the original publication of this article contained mistakes, and the authors would like to correct them. The corrected details are given below.
November 15, 2017: Inflammation
https://www.readbyqxmd.com/read/29136149/pesticide-use-in-agriculture-and-parkinson-s-disease-in-the-agrican-cohort-study
#2
Camille Pouchieu, Clément Piel, Camille Carles, Anne Gruber, Catherine Helmer, Séverine Tual, Elisabeth Marcotullio, Pierre Lebailly, Isabelle Baldi
Background and Aim: Epidemiological studies have reported an increased risk of Parkinson's disease (PD) in farmers exposed to pesticides, but no clear conclusion can be drawn on the type of pesticide and duration of use associated with an effect. In the French agricultural cohort AGRICAN, we assessed associations between PD and pesticide use according to the types of livestock and crops grown, including exposure to some active ingredients with duration of use. Methods: Self-reported PD and history of lifetime exposure to 13 crops and 5 types of animals and pesticide use were collected at enrolment (2005-07) among 181 842 participants...
November 9, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29122549/chronic-low-dose-pro-oxidant-treatment-stimulates-transcriptional-activity-of-telomeric-retroelements-and-increases-telomere-length-in-drosophila
#3
Michala Korandová, Tomáš Krůček, Klára Szakosová, Dalibor Kodrík, Ronald P Kühnlein, Jindřiška Tomášková, Radmila Čapková Frydrychová
It has been proposed that oxidative stress, elicited by high levels of reactive oxygen species, accelerates telomere shortening by erosion of telomeric DNA repeats. While most eukaryotes counteract telomere shortening by telomerase-driven addition of these repeats, telomeric loss in Drosophila is compensated by retrotransposition of the telomeric retroelements HeT-A, TART and TAHRE to chromosome ends. In this study we tested the effect of chronic exposure of flies to non-/sub-lethal doses of paraquat, which is a redox cycling compound widely used to induce oxidative stress in various experimental paradigms including telomere length analyses...
November 6, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29117754/generation-and-characterization-of-new-alleles-of-quiver-qvr-that-encodes-an-extracellular-modulator-of-the-shaker-potassium-channel
#4
Hongyu Ruan, Atsushi Ueda, Xiaomin Xing, Xuxuan Wan, Benjamin Strub, Spencer Mukai, Kaan Certel, David Green, Kyle Belozerov, Wei-Dong Yao, Wayne Johnson, Jim Jung-Ching Lin, Arthur J Hilliker, Chun-Fang Wu
Our earlier genetic screen uncovered a paraquat-sensitive leg-shaking mutant quiver(1) (qvr(1)), whose gene product interacts with the Shaker (Sh) K(+) channel. We also mapped the qvr locus to EY04063 and noticed altered day-night activity patterns in these mutants. Such circadian behavioral defects were independently reported by another group, who employed the qvr(1) allele we supplied them, and attributed the extreme restless phenotype of EY04063 to the qvr gene. However, their report adopted a new noncanonical gene name sleepless (sss) for qvr...
November 9, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/29116999/treatment-outcome-of-combined-continuous-venovenous-hemofiltration-and-hemoperfusion-in-acute-paraquat-poisoning-a-prospective-controlled-trial
#5
Changbin Li, Dayong Hu, Wen Xue, Xinhua Li, Zhen Wang, Zisheng Ai, Yaxiang Song, Xinying Liu, Jiafeng Cheng, Shuling Fan, Limin Zhao, Liya Wang, Chandra Mohan, Ai Peng
OBJECTIVES: To investigate whether combined continuous venovenous hemofiltration and hemoperfusion among paraquat-poisoned patients would improve survival. DESIGN: Prospective, controlled interventional study over 4 years. SETTING: Single, tertiary, academic medical center. PATIENTS: We recruited patients admitted to Shanghai Tenth People's Hospital within 48 hours after paraquat ingestion. Exclusions were under 14 years old, ingestion of paraquat with other toxicants, pregnant, a history of chronic pulmonary disease, psychosis, hyperthyroidism, or diabetes with impaired liver or renal function...
November 7, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29116578/yeast-polyubiquitin-gene-ubi4-deficiency-leads-to-early-induction-of-apoptosis-and-shortened-replicative-lifespan
#6
Wei Zhao, Tao Zhou, Hua-Zhen Zheng, Kun-Pei Qiu, Hong-Jing Cui, Hui Yu, Xin-Guang Liu
Ubiquitin is a 76-amino acid protein that is highly conserved among higher and lower eukaryotes. The polyubiquitin gene UBI4 encodes a unique precursor protein that contains five ubiquitin repeats organized in a head-to-tail arrangement. Although the involvement of the yeast polyubiquitin gene UBI4 in the stress response was reported long ago, there are no reports regarding the underlying mechanism of this involvement. In this study, we used UBI4-deletion and UBI4-overexpressing yeast strains as models to explore the potential mechanism by which UBI4 protects yeast cells against paraquat-induced oxidative stress...
November 7, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29115090/urine-methyl-hippuric-acid-levels-in-acute-pesticide-poisoning-estimation-of-ingested-xylene-volume-and-association-with-clinical-outcome-parameters
#7
Chi Young Choi, NamJun Cho, Su Yeon Park, Samel Park, Hyo Wook Gil, Sae Yong Hong
To determine the relationship between the oral ingestion volume of xylene and methyl hippuric acid (MHA) in urine, we measured MHA in 11 patients whose ingested xylene volume was identified. The best-fit equation between urine MHA and ingested amount of xylene was as follows: y (ingested amount of xylene, mL/kg) = -0.052x² + 0.756x (x = MHA in urine in g/g creatinine). From this equation, we estimated the ingested xylene volume in 194 patients who had ingested pesticide of which the formulation was not available...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29107903/multiwall-carbon-nanotubes-modulate-paraquat-toxicity-in-arabidopsis-thaliana
#8
Xiaoji Fan, Jiahui Xu, Michel Lavoie, W J G M Peijnenburg, Youchao Zhu, Tao Lu, Zhengwei Fu, Tingheng Zhu, Haifeng Qian
Carbon nanotubes can be either toxic or beneficial to plant growth and can also modulate toxicity of organic contaminants through surface sorption. The complex interacting toxic effects of carbon nanotubes and organic contaminants in plants have received little attention in the literature to date. In this study, the toxicity of multiwall carbon nanotubes (MWCNT, 50 mg/L) and paraquat (MV, 0.82 mg/L), separately or in combination, were evaluated at the physiological and the proteomic level in Arabidopsis thaliana for 7-14 days...
November 3, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29107372/hepatotoxicity-of-paraquat-on-common-carp-cyprinus-carpio-l
#9
Junguo Ma, Yuanyuan Li, Weiguo Li, Xiaoyu Li
Paraquat (PQ) is a nonselective herbicide that is used worldwide and has been demonstrated to be a high risk to aquatic organisms. However, relatively little is known about the mechanisms on detoxification and hepatotoxicity of PQ in fish. In the present study, a sub-acute toxicity test of PQ exposure on common carp at 1.596 and 3.192mgL(-1) for 7d was conducted under laboratory conditions. The results showed that the transcriptional levels of cytochrome P450s (CYPs), such as CYP1A, CYP2K, and CYP3A138, GSTα and GSTpi, and export pump gene MDR1, as well as the erythromycin-N-demethylase (ERND) activity were generally up-regulated by PQ exposure for 7d, indicating that these genes or enzymes are potentially involved in the detoxification of PQ in the fish liver...
October 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29104250/a-pilot-study-in-cameroon-to-understand-safe-uses-of-pesticides-in-agriculture-risk-factors-for-farmers-exposure-and-management-of-accidental-cases
#10
Guy Bertrand Pouokam, William Lemnyuy Album, Alice S Ndikontar, Mohamed El Hady Sidatt
Chemical pesticides are widely used in Cameroon for agricultural production. In 2015, more than 600 pesticide products were approved for use in various foodstuffs. Much misuse of these chemicals by farmers has been documented in rural and urban settings. This pilot study aims to contribute to the improvement of the health of the population and the environmental preservation by identifying pesticide-poisoning cases, the most incriminated products and critical risk factors of exposure. Questionnaires were administered to pesticide vendors, farmers and health personnel, and observations made on farmers' practices at their work places...
November 1, 2017: Toxics
https://www.readbyqxmd.com/read/29100984/sexual-dimorphism-in-oxidant-induced-adaptive-homeostasis-in-multiple-wild-type-d-melanogaster-strains
#11
Laura C D Pomatto, Sarah Wong, John Tower, Kelvin J A Davies
Sexual dimorphism includes the physical and reproductive differences between the sexes, including differences that are conserved across species, ranging from the common fruit fly, Drosophila melanogaster, to humans. Sex-dependent variations in adaptive homeostasis, and adaptive stress responses may offer insight into the underlying mechanisms for male and female survival differences and into differences in chronic disease incidence and severity in humans. Earlier work showed sex-specific differences in adaptive responses to oxidative stressors in hybrid laboratory strains of D...
October 31, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29100808/mitochondrial-bioenergetics-and-locomotor-activity-are-altered-in-zebrafish-danio-rerio-after-exposure-to-the-bipyridylium-herbicide-diquat
#12
Xiao H Wang, Christopher L Souders, Yuan H Zhao, Christopher J Martyniuk
Diquat is a non-selective bipyridylium herbicide which has replaced its sister compound paraquat, as paraquat is associated to an increased risk for Parkinson's disease. However, the propensity of diquat to propagate reactive oxygen species ensures that diquat remains an exposure risk in non-target organisms. In this study, zebrafish (Danio rerio) embryos were exposed to diquat (1, 10, 100μM) beginning at ∼6hours post fertilization for up to 7days to learn more about the mechanisms underlying diquat toxicity during vertebrate development...
October 31, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29099997/early-metabolome-profiling-and-prognostic-value-in-paraquat-poisoned-patients-based-on-ultra-performance-liquid-chromatography-coupled-to-quadrupole-time-of-flight-mass-spectrometry
#13
Lufeng Hu, Guangliang Hong, Yahui Tang, Xianqin Wang, Congcong Wen, Feiyan Lin, Zhongqiu Lu
Paraquat (PQ) has caused countless deaths throughout the world. There remains no effective treatment for PQ poisoning. Here we study the blood metabolome of PQ-poisoned patient using ultra performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS). Patients were divided into groups according blood PQ concentration. Healthy subjects served as controls. Metabolic features were statistically analyzed using multivariate pattern-recognition techniques to identify the most important metabolites...
November 3, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29098875/high-dose-immunosuppression-to-prevent-death-after-paraquat-self-poisoning-a-randomised-controlled-trial
#14
Indika Gawarammana, Nicholas A Buckley, Fahim Mohamed, Kamal Naser, K Jeganathan, P L Ariyananada, Klintean Wunnapuk, Timothy A Dobbins, John A Tomenson, Martin F Wilks, Michael Eddleston, Andrew H Dawson
CONTEXT: Intentional self-poisoning with the herbicide paraquat has a very high case-fatality and is a major problem in rural Asia and Pacific. OBJECTIVES: We aimed to determine whether the addition of immunosuppression to supportive care offers benefit in resource poor Asian district hospitals. MATERIALS AND METHODS: We performed a randomised placebo-controlled trial comparing immunosuppression (intravenous cyclophosphamide up to 1 g/day for two days and methylprednisolone 1 g/day for three days, and then oral dexamethasone 8 mg three-times-a-day for 14 days) with saline and placebo tablets, in addition to standard care, in patients with acute paraquat self-poisoning admitted to six Sri Lankan hospitals between 1st March 2007 and 15th November 2010...
November 3, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29097282/isolation-of-carboxylesterase-esterase-fe4-from-apis-cerana-cerana-and-its-role-in-oxidative-resistance-during-adverse-environmental-stress
#15
Manli Ma, Haihong Jia, Xuepei Cui, Na Zhai, Hongfang Wang, Xingqi Guo, Baohua Xu
Carboxylesterases (CarEs) play vital roles in metabolising different physiologically important endogenous compounds and in detoxifying various harmful exogenous compounds in insects. Multiple studies of CarEs have focused on pesticide metabolism in insects, while few studies have aimed to identify CarE functions in oxidative resistance, particularly in Apis cerana cerana. In this study, we isolated a carboxylesterase gene, esterase FE4, from Apis cerana cerana and designated it towards an exploration of its roles as an antioxidant and in detoxification...
October 30, 2017: Biochimie
https://www.readbyqxmd.com/read/29096617/effect-of-prohibiting-the-use-of-paraquat-on-pesticide-associated-mortality
#16
Jinyong Kim, Sang Do Shin, Seungmin Jeong, Gil Joon Suh, Young Ho Kwak
BACKGROUND: Paraquat is associated with a high rate of fatalities in acute poisoning. This study aimed to examine the association between the national public health policy that banned the use of paraquat and the incidence of pesticide-associated mortality. METHODS: All external causes of death from 2009 to 2013 of Korea were analyzed. The intervention was a national public health policy that annulled the authorized use (2011) and banned the purchase of paraquat (2012)...
November 2, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29082819/prognostic-comparison-of-goal-oriented-hemoperfusion-and-routine-hemoperfusion-combined-with-continuous-venovenous-hemofiltration-for-paraquat-poisoning
#17
Xuming Zhao, Yan Xiao, Jianliang Zhu, Zhiping Xu, Lijun Liu, Jinsong Zhang
Objective To investigate the impact of goal-oriented hemoperfusion (HP) with monitoring of the paraquat concentration on the prognosis of patients with acute paraquat poisoning. Methods This prospective observational study involved patients with acute paraquat poisoning admitted from March 2012 to September 2015. The patients received either goal-oriented or routine HP. All other treatments were the same between the two groups. The primary endpoint was 28-day mortality after poisoning. The secondary endpoints were the incidence of organ dysfunction within 7 days and 7-day mortality...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29081107/-a-case-report-of-acute-severe-paraquat-poisoning-clinical-cure
#18
H L Liu, X D Jian, D X Wang
No abstract text is available yet for this article.
July 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29081105/-experimental-study-scavenging-effect-of-paraquat-by-hemoperfusion
#19
Y H Pei, Y Z He, X G Zhang, B S Sun
Objective: To determine the scavenging effect and the change of metabolism of paraquat (PQ) using hemoperfusion (HP) once and twice within 12 hours after intoxication and explore the better scheme of HP. Methods: 18 beagles were randomly divided into 3 groups. Single HP group, Double HP group and Control group. Peripheral veins blood was collected at different times within 48 hours after exposure in each group. Toxin concentration was measured, analyzed and compared among 3 groups. Results: 6 hours after exposure, Single HP group and Double HP group has finished the first HP treatment, and the concentration of PQ was lower than that of the control group, the difference was statistically significant (P<0...
July 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29072814/multiple-resistance-to-glyphosate-paraquat-and-accase-inhibiting-herbicides-in-italian-ryegrass-populations-from-california-confirmation-and-mechanisms-of-resistance
#20
Parsa Tehranchian, Vijay Nandula, Mithila Jugulam, Karthik Putta, Marie Jasieniuk
BACKGROUND: Glyphosate, paraquat and acetyl CoA carboxylase (ACCase)-inhibiting herbicides are widely used in California annual and perennial cropping systems. Recently, glyphosate, paraquat, and ACCase- and acetolactate synthase (ALS)-inhibitor resistance was confirmed in several Italian ryegrass populations from the Central Valley of California. This research characterized the possible mechanisms of resistance. RESULTS: Multiple-resistant populations (MR1, MR2) are resistant to several herbicides from at least three modes of action...
October 26, 2017: Pest Management Science
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