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Paraquat

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https://www.readbyqxmd.com/read/28525809/one-step-preparation-of-nanostructured-martite-catalyst-and-graphite-electrode-by-glow-discharge-plasma-for-heterogeneous-electro-fenton-like-process
#1
Alireza Khataee, Saeed Sajjadi, Aliyeh Hasanzadeh, Behrouz Vahid, Sang Woo Joo
Natural Martite ore particles and graphite were modified by alternating current (AC) glow discharge plasma to form nanostructured catalyst and cathode electrode for using in the heterogeneous-electro Fenton-like (Het-EF-like) process. The performance of the plasma-treated martite (PTM) and graphite electrode (PTGE) was studied for the treatment of paraquat herbicide in a batch system. 85.78% degradation efficiency for 20 mg L(-1) paraquat was achieved in the modified process under desired operational conditions (i...
May 16, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28514303/continuous-venovenous-hemofiltration-in-the-management-of-paraquat-poisoning-a-meta-analysis-of-randomized-controlled-trials
#2
Guodong Lin, Jianhai Long, Yuan Luo, Yongan Wang, Qiu Zewu
BACKGROUND: Paraquat (PQ) poisoning is a widespread occurrence, especially in underdeveloped areas. The treatment of PQ poisoning has always been difficult, and there is currently no definite effective treatment. Continuous venovenous hemofiltration (CVVH) treatment for PQ poisoning has been widely used in clinical practice; however, its effect remains uncertain. Accordingly, the purpose of this meta-analysis was to evaluate the efficacy of CVVH in the treatment of PQ poisoning. METHODS: We searched for relevant trials using PubMed, Embase, the Cochrane Library, and 3 Chinese databases, the Chinese BioMedical Literature Database, National Knowledge Infrastructure Database, and Wanfang Database...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28508189/the-contribution-of-superoxide-radical-to-cadmium-toxicity-in-e-coli
#3
Milini Thomas, Ludmil Benov
Numerous reports suggest the involvement of oxidative stress in cadmium toxicity, but the nature of the reactive species and the mechanism of Cd-induced oxidative damage are not clear. In this study, E. coli mutants were used to investigate mechanisms of Cd toxicity. Effects of Cd on metabolic activity, production of superoxide radical by the respiratory chain, and induction of enzymes controlled by the soxRS regulon were investigated. In E. coli, the soxRS regulon controls defense against O2·(-)and univalent oxidants...
May 15, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28507474/anacardium-microcarpum-extract-and-fractions-protect-against-paraquat-induced-toxicity-in-drosophila-melanogaster
#4
Katiane Raquel Müller, Illana Kemmerich Martins, Nathane Rosa Rodrigues, Litiele Cezar da Cruz, Valter Menezes Barbosa Filho, Giulianna Echeverria Macedo, Gustavo Felipe da Silva, Jean Paul Kamdem, Irwin Rose Alencar de Menezes, Jeferson Luis Franco, Thaís Posser
Anacardium microcarpum Ducke (Anacardiaceae) is a native species of Brazil used in folk medicine for the treatment of several illnesses although its antioxidant activity has been reported in vitro, there is no evidence of this effect in an in vivo model. Here, we investigated the potential protective effect of hydroalcoholic extract (AMHE), methanol (AMMF) and acetate (AMAF) fraction of A. microcarpum against paraquat toxicity on survivorship, locomotor performance, antioxidant enzymes activity and reactive species using Drosophila melanogaster...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28506637/thiamine-and-benfotiamine-prevent-stress-induced-suppression-of-hippocampal-neurogenesis-in-mice-exposed-to-predation-without-affecting-brain-thiamine-diphosphate-levels
#5
Julie Vignisse, Margaux Sambon, Anna Gorlova, Dmitrii Pavlov, Nicolas Caron, Brigitte Malgrange, Elena Shevtsova, Andrey Svistunov, Daniel C Anthony, Natalyia Markova, Natalyia Bazhenova, Bernard Coumans, Bernard Lakaye, Pierre Wins, Tatyana Strekalova, Lucien Bettendorff
Thiamine is essential for normal brain function and its deficiency causes metabolic impairment, specific lesions, oxidative damage and reduced adult hippocampal neurogenesis (AHN). Thiamine precursors with increased bioavailability, especially benfotiamine, exert neuroprotective effects not only for thiamine deficiency (TD), but also in mouse models of neurodegeneration. As it is known that AHN is impaired by stress in rodents, we exposed C57BL6/J mice to predator stress for 5 consecutive nights and studied the proliferation (number of Ki67-positive cells) and survival (number of BrdU-positive cells) of newborn immature neurons in the subgranular zone of the dentate gyrus...
May 12, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28506248/paraquat-and-parkinson-s-disease-a-systematic-review-protocol-according-to-the-ohat-approach-for-hazard-identification
#6
Carolina Vaccari, Regina El Dib, João Lauro V de Camargo
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative condition that has genetic susceptibility, aging, and exposure to certain chemicals as risk factors. In recent decades, epidemiological and experimental studies have investigated the role of pesticides in the development of PD, in particular that of the herbicide paraquat. Here, we, therefore, aim to systematically review the association between paraquat exposure and PD. METHODS: Observational studies (cohort, case-control, and cross-sectional) eligible for this systematic review will enroll any participant who was occupationally and/or environmentally exposed to paraquat...
May 15, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28503972/molecular-mechanisms-of-anti-oxidant-and-anti-aging-effects-induced-by-convallatoxin-in-caenorhabditis-elegans
#7
Jia Xu, Youming Guo, Tianzhuo Sui, Qifei Wang, Yue Zhang, Ruining Zhang, Mingyang Wang, Shuwen Guan, Liping Wang
Convallatoxin is widely used as a cardiac glycoside in acute and chronic congestive heart-failure and paroxysmal tachycardia, with many effects and underlying protective mechanisms on inflammation and cellular proliferation. However, convallatoxin has not been investigated in its antioxidant effects and lifespan extension in Caenorhabditis elegans. In this study, we found that convallatoxin (20 μM) could significantly prolong the lifespan of wild-type C. elegans up to 16.3% through daf-16, but not sir-2.1 signaling and increased thermotolerance and resistance to paraquat-induced oxidative stress...
May 14, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28501785/experimental-study-of-sucralfate-intervention-for-paraquat-poisoning-in-rats
#8
Zhu Junbo, Yu Yongtao, Li Hongbo, Zheng Fenshuang, Lin Ruyun, Yang Chun'ai
OBJECTIVE: This study explored the effects of sucralfate intervention as a novel treatment for paraquat (PQ) poisoning in Sprague-Dawley (SD) rats. METHODS: After PQ poisoning, the SD rats were randomly divided into the PQ control group (treated with normal saline), the sodium bicarbonate (SB) treatment group, and the sucralfate (LTL) treatment group. Then, the rats were administered normal saline, sodium bicarbonate solution, or sucralfate suspension as an intervention by gastric lavage...
April 26, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28501144/sequential-injection-differential-pulse-voltammetric-method-based-on-screen-printed-carbon-electrode-modified-with-carbon-nanotube-nafion-for-sensitive-determination-of-paraquat
#9
Prakit Chuntib, Suwaphid Themsirimongkon, Surin Saipanya, Jaroon Jakmunee
The screen-printed carbon electrode (SPCE) modified with various nanoparticles has been studied for using as a working electrode in voltammetric technique. The electrochemical behavior of paraquat on different electrodes was studied by cyclic voltammetry (CV), and then differential pulse voltammetry (DPV) has been employed for trace analysis of paraquat based on redox reaction which the peak current was directly proportional to the concentration of paraquat in the solution. The SPCE modified with carbon nanotube dispersed in Nafion and ethanol (SPCE-CNT/Nafion) gave the best result...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28493927/protective-effects-and-functional-mechanisms-of-lactobacillus-gasseri-sbt2055-against-oxidative-stress
#10
Eiji Kobatake, Hisako Nakagawa, Takahiro Seki, Tadaaki Miyazaki
Lactobacillus gasseri SBT2055 (LG2055) is one of the probiotic lactic acid bacteria. Recently, we demonstrated that feeding with LG2055 extended the lifespan of Caenorhabditis elegans and that the prolongevity effect was dependent upon the regulation of oxidative stress response. In this study, we assessed whether LG2055 regulated the oxidative stress response of mammalian cells. In NIH-3T3 cells and primary mouse embryonic fibroblast cells, low cell proliferation rates and high reactive oxygen species levels were observed following paraquat treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28492119/paraquat-poisoning-acute-lung-injury-a-missed-diagnosis
#11
Sipho D Ntshalintshali, Thandekile C Manzini
Paraquat is a herbicide of great toxicological importance because it is associated with high mortality rates, mainly due to respiratory failure. We report the case of a 28-year-old man admitted to the casualty department at Ngwelezana Hospital, Empangeni, KwaZulu-Natal, South Africa, with a history of vomiting and abdominal pain after ingestion of ~100 mL of an unknown substance, later identified as paraquat, together with an unknown amount of alcohol, in a suicide attempt. He developed respiratory distress associated with lung parenchymal infiltrates that required ventilatory support and later a spontaneous pneumothorax, and died in the intensive care unit...
April 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28480221/liver-x-receptor-agonist-to901317-attenuates-paraquat-induced-acute-lung-injury-through-inhibition-of-nf-%C3%AE%C2%BAb-and-jnk-p38-mapk-signal-pathways
#12
Xiao Hu, Haitao Shen, Yu Wang, Min Zhao
Paraquat (PQ) is a widely used herbicide with extremely high poisoning mortality mostly from acute lung injury (ALI) or progressive pulmonary fibrosis. Toxicity mechanisms remain unclear, but a redox cycling process that generates reactive oxygen species (ROS) is involved, as are inflammation and cell apoptosis. We established an ALI mouse model by intraperitoneal injection of PQ (28 mg/kg) and then investigated the effects of a potent liver X receptor (LXR) agonist, TO901317 (5 or 20 mg/kg), injected intraperitoneally 30 min after PQ administration...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28480199/a-rare-case-of-epilepsy-and-acute-pancreatitis-induced-by-severe-paraquat-poisoning
#13
Hongxia Dong, Xiaobo Peng, Zewu Qiu
Paraquat can lead to injury of multiple organs. As there is no specific treatment for paraquat poisoning, it represents a serious clinical problem. Antioxidants are required to treat oxidative stress in paraquat poisoning and paraquat-induced injury. In this study, we report on successful treatment of a rare case of epilepsy and acute pancreatitis caused by paraquat poisoning. A 29-year-old woman at our hospital presented with a 13-day history of nausea and vomiting after ingesting 20 mL of paraquat (20% W/V)...
April 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28474156/jnk-inhibitor-sp600125-attenuates-paraquat-induced-acute-lung-injury-an-in-vivo-and-in-vitro-study
#14
Haitao Shen, Na Wu, Yu Wang, Xinfei Han, Qiang Zheng, Xue Cai, Honglei Zhang, Min Zhao
Acute lung injury (ALI) is a major complication soon after paraquat poisoning and rapidly progresses with high mortality. However, the specific mechanism underlying paraquat-induced ALI is still unclear. In this study, the mechanism underlying the protective effects of SP600125 on paraquat-induced ALI was investigated according to oxidative stress, inflammation, and apoptosis. The rats were randomly assigned into the control group (CON), the paraquat poisoning group (PQ), and the PQ + SP600125 group (SP). A549 cells were divided into the Con group, Pq group, and Sp group...
May 4, 2017: Inflammation
https://www.readbyqxmd.com/read/28467894/potential-mechanisms-of-development-dependent-adverse-effects-of-the-herbicide-paraquat-in-3d-rat-brain-cell-cultures
#15
J Sandström, A Broyer, D Zoia, C Schilt, C Greggio, M Fournier, K Q Do, F Monnet-Tschudi
Exposure to environmental toxicants during vulnerable windows of brain development is suspected to raise the prevalence for neurological dysfunctions at later stages in life. Differentiation processes and changes in morphology, as well as a lack of physiological barriers, might be reasons that render a developing brain more susceptible to neurotoxicants than an adult. However, also the intrinsic capacity of cells to combat toxicant induced cellular stress might differ between the immature- and mature brain...
April 30, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28460087/base-excision-repair-variants-and-pesticide-exposure-increase-parkinson-s-disease-risk
#16
Laurie H Sanders, Kimberly C Paul, Evan H Howlett, Hakeem Lawal, Sridhar Boppana, Jeff M Bronstein, Beate Ritz, J Timothy Greenamyre
Exposure to certain pesticides induces oxidative stress and increases Parkinson's disease (PD) risk. Mitochondrial DNA (mtDNA) damage is found in dopaminergic neurons in idiopathic PD and following pesticide exposure in experimental models thereof. Base excision repair (BER) is the major pathway responsible for repairing oxidative DNA damage in cells. Whether single nucleotide polymorphisms (SNPs) in BER genes alone or in combination with pesticide exposure influence PD risk is unknown. We investigated the contributions of functional SNPs in 2 BER genes (APEX1 and OGG1) and mitochondrial dysfunction- or oxidative stress-related pesticide exposure, including paraquat, to PD risk...
April 29, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28451437/an-assessment-of-agricultural-pesticide-use-in-iran-2012-2014
#17
Zaim Morteza, Seyed Behzad Mousavi, Mohammad Ali Baghestani, Antero Aitio
BACKGROUND: This is the first published assessment on agricultural pesticide use in Iran with the aim to identify pesticide products with a potential of causing acute or chronic hazard to human health. It also establishes a baseline for future comparisons and for trend assessments. METHODS: The amounts of imported technical materials for formulation by local manufacturers as well as imported final product formulations were extracted from the registration data of the Plant Protection Organization of Iran in 2012-2014...
2017: Journal of Environmental Health Science & Engineering
https://www.readbyqxmd.com/read/28447071/the-effects-of-reduced-rpd3-levels-on-fly-physiology
#18
Jared K Woods, Tahereh Ziafazeli, Blanka Rogina
BACKGROUND: Rpd3 is a conserved histone deacetylase that removes acetyl groups from lysine residues within histones and other proteins. Reduction or inhibition of Rpd3 extends longevity in yeast, worms, and flies. Previous studies in flies suggest an overlap with the mechanism of lifespan extension by dietary restriction. However, the mechanism of rpd3's effects on longevity remains unclear. OBJECTIVES: In this study we investigated how rpd3 reduction affects fly spontaneous physical activity, fecundity, and stress resistance...
March 31, 2017: Nutrition and Healthy Aging
https://www.readbyqxmd.com/read/28446247/difference-in-oxidative-stress-tolerance-between-rice-cultivars-estimated-with-chlorophyll-fluorescence-analysis
#19
Ichiro Kasajima
BACKGROUND: Oxidative stress is considered to be involved in growth retardation of plants when they are exposed to a variety of biotic and abiotic stresses. Despite its potential importance in improving crop production, comparative studies on oxidative stress tolerance between rice (Oryza sativa L.) cultivars are limited. This work describes the difference in term of oxidative stress tolerance between 72 rice cultivars. METHODS: 72 rice cultivars grown under naturally lit greenhouse were used in this study...
April 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28446034/free-radicals-impair-the-anti-oxidative-stress-activity-of-dj-1-through-the-formation-of-sds-resistant-dimer
#20
Tatsuki Yasuda, Takeshi Niki, Hiroyoshi Ariga, Sanae M M Iguchi-Ariga
DJ-1 is a causative gene for familial Parkinson's disease (PD). Loss-of-function of DJ-1 protein is suggested to contribute to the onset of PD, but the causes of DJ-1 dysfunction remain insufficiently elucidated. In this study, we found that the SDS-resistant irreversible dimer of DJ-1 protein was formed in human dopaminergic neuroblastoma SH-SY5Y cells, when the cells were exposed to massive superoxide inducers such as paraquat and diquat. The dimer was also formed in vitro by superoxide in PQ redox cycling system and hydroxyl radical produced in Fenton reaction...
April 26, 2017: Free Radical Research
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