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https://www.readbyqxmd.com/read/27925415/utilization-of-red-light-emitting-cdte-nanoparticles-for-the-trace-level-detection-of-harmful-herbicides-in-adulterated-food-and-agricultural-crops
#1
Nilanjan Dey, Deepa Bhagat, Durgadas Cherukaraveedu, Santanu Bhattacharya
Red-light-emitting water-soluble semiconducting quantum dots (QDs) were synthesized by using a wide variety of commercially available thiol-type capping agents. QDs with a negatively charged nanosurface showed excellent selectivity for paraquat (PQ) at pH 7.4 over other commonly encountered pesticides/herbicides, including diquat (DQ). The presence of a 4,4'-bis-pyridinium unit in PQ enabled it to initiate long-range aggregation, thereby leading to the formation of nanostructures with excellent emission-quenching behavior...
November 7, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27922032/chemically-induced-oxidative-stress-affects-ash-neuronal-function-and-behavior-in-c-elegans
#2
Eleni Gourgou, Nikos Chronis
Oxidative stress (OS) impact on a single neuron's function in vivo remains obscure. Using C. elegans as a model organism, we report the effect of paraquat (PQ)-induced OS on wild type worms on the function of the ASH polymodal neuron. By calcium (Ca(2+)) imaging, we quantified ASH activation upon stimulus delivery. PQ-treated worms displayed higher maximum depolarization (peak of the Ca(2+) transients) compared to untreated animals. PQ had a similar effect on the ASH neuron response time (rising slope of the Ca(2+) transients), except in very young worms...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27919828/mucuna-pruriens-reduces-inducible-nitric-oxide-synthase-expression-in-parkinsonian-mice-model
#3
Satyndra Kumar Yadav, Sachchida Nand Rai, Surya Pratap Singh
Parkinson's disease is one of the most common neurodegenerative disease found in aged peoples. Plentiful studies are being conducted to find a suitable and effective cure for this disease giving special impetus on use of herbal plants. The study aimed at investigating the effect of ethanolic extract of Mucuna pruriens (Mp) on level of nitric oxide (NO) in paraquat (PQ) induced Parkinson's disease (PD) mouse model and its subsequent contribution to lipid peroxidation. Twenty four Swiss albino mice were divided into three groups; Control, PQ and PQ+Mp...
December 2, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27916526/the-mitochondrial-lon-protease-is-required-for-age-specific-and-sex-specific-adaptation-to-oxidative-stress
#4
Laura C D Pomatto, Caroline Carney, Brenda Shen, Sarah Wong, Kelly Halaszynski, Matthew P Salomon, Kelvin J A Davies, John Tower
Multiple human diseases involving chronic oxidative stress show a significant sex bias, including neurodegenerative diseases, cancer, immune dysfunction, diabetes, and cardiovascular disease. However, a possible molecular mechanism for the sex bias in physiological adaptation to oxidative stress remains unclear. Here, we report that Drosophila melanogaster females but not males adapt to hydrogen peroxide stress, whereas males but not females adapt to paraquat (superoxide) stress. Stress adaptation in each sex requires the conserved mitochondrial Lon protease and is associated with sex-specific expression of Lon protein isoforms and proteolytic activity...
November 23, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27891135/ros-mediated-inhibition-of-s-nitrosoglutathione-reductase-contributes-to-the-activation-of-anti-oxidative-mechanisms
#5
Izabella Kovacs, Christian Holzmeister, Markus Wirtz, Arie Geerlof, Thomas Fröhlich, Gaby Römling, Gitto T Kuruthukulangarakoola, Eric Linster, Rüdiger Hell, Georg J Arnold, Jörg Durner, Christian Lindermayr
Nitric oxide (NO) has emerged as a signaling molecule in plants being involved in diverse physiological processes like germination, root growth, stomata closing and response to biotic and abiotic stress. S-nitrosoglutathione (GSNO) as a biological NO donor has a very important function in NO signaling since it can transfer its NO moiety to other proteins (trans-nitrosylation). Such trans-nitrosylation reactions are equilibrium reactions and depend on GSNO level. The breakdown of GSNO and thus the level of S-nitrosylated proteins are regulated by GSNO-reductase (GSNOR)...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27890776/epigallocatechin-3-gallate-alleviates-paraquat-induced-acute-lung-injury-and-inhibits-upregulation-of-toll-like-receptors
#6
Haitao Shen, Na Wu, Zhenning Liu, Hongyu Zhao, Min Zhao
AIMS: To evaluate the detoxifying effect of epigallocatechin-3-gallate (EGCG) on paraquat (PQ)-induced acute lung injury in mice, and to explore the action mechanisms. MAIN METHODS: Following administration of PQ, the mice received a low, a medium or a high dose of EGCG daily for three days. Histopathology of the lungs were examined by H&E staining. The levels of inflammatory cytokines, such as TNF-α, IL-1β and IL-6, in the bronchoalveolar lavage fluid were measured by enzyme-linked immunosorbent assay...
November 24, 2016: Life Sciences
https://www.readbyqxmd.com/read/27884773/an-intelligent-prognostic-system-for-analyzing-patients-with-paraquat-poisoning-using-arterial-blood-gas-indexes
#7
Lufeng Hu, Feiyan Lin, Huaizhong Li, Changfei Tong, Zhifang Pan, Jun Li, Huiling Chen
The arterial blood gas (ABG) test is used to assess gas exchange in the lung, and the acid-base level in the blood. However, it is still unclear whether or not ABG test indexes correlate with paraquat (PQ) poisoning. This study investigates the predictive value of ABG tests in prognosing patients with PQ poisoning; it also identifies the most significant indexes of the ABG test. An intelligent machine learning-based system was established to effectively give prognostic analysis of patients with PQ poisoning based on ABG indexes...
November 21, 2016: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/27884192/role-of-cytochrome-c-in-%C3%AE-synuclein-radical-formation-implications-of-%C3%AE-synuclein-in-neuronal-death-in-maneb-and-paraquat-induced-model-of-parkinson-s-disease
#8
Ashutosh Kumar, Douglas Ganini, Ronald P Mason
BACKGROUND: The pathological features of Parkinson's disease (PD) include an abnormal accumulation of α-synuclein in the surviving dopaminergic neurons. Though PD is multifactorial, several epidemiological reports show an increased incidence of PD with co-exposure to pesticides such as Maneb and paraquat (MP). In pesticide-related PD, mitochondrial dysfunction and α-synuclein oligomers have been strongly implicated, but the link between the two has not yet been understood. Similarly, the biological effects of α-synuclein or its radical chemistry in PD is largely unknown...
November 24, 2016: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/27883937/atorvastatin-protected-from-paraquat-induced-cytotoxicity-in-alveolar-macrophages-via-down-regulation-of-tlr-4
#9
Nazli Alizadeh-Tabrizi, Hassan Malekinejad, Soheil Varasteh, Hadi Cheraghi
The current study designed to clarify the mechanism of paraquat-induced cytotoxicity and protective effects of Atorvastatin on freshly isolated alveolar macrophages (AMs). AMs were collected via bronchoalveolar lavage and exposed to various concentrations of paraquat in the presence and absence of atorvastatin for 24h. Cell viability, myeloperoxidase activity; nitric oxide generation and total antioxidant capacity were assessed. Expression of TLR-4 at mRNA and protein levels were studied by using PCR and western blot methods Atorvastatin enhanced the paraquat-reduced cell viability and reduced the paraquat-induced myeloperoxidase activity and nitric oxide production...
November 18, 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27867393/melatonin-application-to-pisum-sativum-l-seeds-positively-influences-the-function-of-the-photosynthetic-apparatus-in-growing-seedlings-during-paraquat-induced-oxidative-stress
#10
Katarzyna Szafrańska, Russel J Reiter, Małgorzata M Posmyk
Melatonin, due to its pleiotropic effects plays an important role improving tolerance to stresses. Plants increase endogenous melatonin synthesis when faced with harsh environments as well as exogenously applied melatonin limits stress injuries. Presented work demonstrated that single melatonin application into the seeds during pre-sowing priming improved oxidative stress tolerance of growing seedlings exposed to paraquat (PQ). PQ is a powerful herbicide which blocks the process of photosynthesis under light conditions due to free radicals excess production, when O2 is rapidly converted to [Formula: see text] and subsequently to other reactive oxygen species...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27866563/-recent-advance-of-cytokines-in-the-pathogenesis-of-lung-injury-induced-by-paraquat-poisoning
#11
W Y Fang, X S Xie, S G Feng
No abstract text is available yet for this article.
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27866555/-two-cases-of-acute-poisoning-of-paraquat-with-dursban-and-paraquat-with-bromadiolone
#12
H B Zhou, M Xia
No abstract text is available yet for this article.
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27866548/-effect-of-heme-oxygenase-1-transduced-by-cell-penetrating-peptide-pep-1-on-renal-injury-in-rats-with-acute-paraquat-poisoning
#13
X Wang, Y X Zhao, H X Li, A J Li, S Liu, H M Chen, W Z Cui
Objective: To study the effects of heme oxygenase-1 transduced by cell penetrating peptide PEP-1 on renal injury in acute paraquat-induced rats. Methods: The fusion protein PEP-1/HO-1 was manufactured by genetic engineering methods. One hundred and twenty-six healthy adult Sprague-Dawley (SD) rats (63 male, 63 female) were randomly divided into three groups: (1) Control group: 42 rats, (2) Poisoned group: 42 rats, (3) PEP-1/HO-1 intervention group: 42 rats. The rats in Poisoned group and intervention group were treated intraperitoneally with paraquat (25 mg/kg) deliquated with normal saline...
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27861562/digitor-dasciz-has-multiple-roles-in-drosophila-development
#14
Saheli Sengupta, Uttama Rath, Changfu Yao, Michael Zavortink, Chao Wang, Jack Girton, Kristen M Johansen, Jørgen Johansen
In this study we provide evidence that the spindle matrix protein Skeletor in Drosophila interacts with the human ASCIZ (also known as ATMIN and ZNF822) ortholog, Digitor/dASCIZ. This interaction was first detected in a yeast two-hybrid screen and subsequently confirmed by pull-down assays. We also confirm a previously documented function of Digitor/dASCIZ as a regulator of Dynein light chain/Cut up expression. Using transgenic expression of a mCitrine-labeled Digitor construct, we show that Digitor/dASCIZ is a nuclear protein that is localized to interband and developmental puff chromosomal regions during interphase but redistributes to the spindle region during mitosis...
2016: PloS One
https://www.readbyqxmd.com/read/27854199/chyawanprash-a-formulation-of-traditional-ayurvedic-medicine-shows-a-protective-effect-on-skin-photoaging-in-hairless-mice
#15
Yuki Takauji, Kyoko Morino, Kensuke Miki, Mohammad Hossain, Dai Ayusawa, Michihiko Fujii
OBJECTIVE: Chronic exposure to ultraviolet (UV) radiation induces skin photoaging (premature skin aging). UV irradiation generates reactive oxygen species (ROS), which are shown to play a pivotal role in skin photoaging. Ayurveda is a holistic traditional medical system, and Chyawanprash is one of the most popular formulations in Ayurveda. Since maintenance of the function and appearance of skin is important, we examined whether Chyawanprash has a protective effect on skin photoaging...
November 2016: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27829983/melatoninergic-system-in-parkinson-s-disease-from-neuroprotection-to-the-management-of-motor-and-nonmotor-symptoms
#16
REVIEW
Josiel Mileno Mack, Marissa Giovanna Schamne, Tuane Bazanella Sampaio, Renata Aparecida Nedel Pértile, Pedro Augusto Carlos Magno Fernandes, Regina P Markus, Rui Daniel Prediger
Melatonin is synthesized by several tissues besides the pineal gland, and beyond its regulatory effects in light-dark cycle, melatonin is a hormone with neuroprotective, anti-inflammatory, and antioxidant properties. Melatonin acts as a free-radical scavenger, reducing reactive species and improving mitochondrial homeostasis. Melatonin also regulates the expression of neurotrophins that are involved in the survival of dopaminergic neurons and reduces α-synuclein aggregation, thus protecting the dopaminergic system against damage...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27829285/immunomodulation-of-cell-penetrating-tat-metallothionein-for-successful-outcome-of-xenotransplanted-pancreatic-islet
#17
Min Jun Kim, Yong Hwa Hwang, Yong Hee Kim, Dong Yun Lee
Pancreatic islet transplantation is a promising treatment for treatment of type 1 diabetes; however, transplantation outcomes have been disappointing due to early graft loss that is mediated by many immune responses. Immune cells not only directly damaged islet but also produced reactive oxygen species (ROS), which is highly toxic to islet cells. Metallothionein (MT) can provide protection against oxidative stress by scavenging various range of ROS including superoxide, hydroxyl radical, hydrogen peroxide, and nitric oxide...
November 10, 2016: Journal of Drug Targeting
https://www.readbyqxmd.com/read/27824090/prognostic-value-of-hematological-parameters-in-patients-with-paraquat-poisoning
#18
Deng-Chuan Zhou, Hong Zhang, Zhi-Ming Luo, Qi-Xing Zhu, Cheng-Fan Zhou
Paraquat (PQ) is a non-selective contact herbicide, and acute PQ poisoning has a high mortality. The aim of the present study is to evaluate the prognostic value of hematological parameters in patients with acute PQ poisoning. We retrospectively reviewed the records of patients with acute PQ poisoning from January 2010 to December 2015 at the First Affiliated Hospital, Anhui Medical University (Hefei, China). A total of 202 patients were included in the study, and the 30-day mortality was 51.98%. Leukocyte, neutrophil counts and neutrophil-lymphocyte ratio (NLR) were significantly higher in non-survivors than in survivors...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818165/cellular-ros-imaging-with-hydro-cy3-dye-is-strongly-influenced-by-mitochondrial-membrane-potential
#19
Alexander V Zhdanov, Gabriella Aviello, Ulla G Knaus, Dmitri B Papkovsky
BACKGROUND: Hydrocyanines are widely used as fluorogenic probes to monitor reactive oxygen species (ROS) generation in cells. Their brightness, stability to autoxidation and photobleaching, large signal change upon oxidation, pH independence and red/near infrared emission are particularly attractive for imaging ROS in live tissue. METHODS: Using confocal fluorescence microscopy we have examined an interference of mitochondrial membrane potential (ΔΨm) with fluorescence intensity and localisation of a commercial hydro-Cy3 probe in respiring and non-respiring colon carcinoma HCT116 cells...
November 4, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27810110/comparing-the-acute-sensitivity-of-growth-and-photosynthetic-endpoints-in-three-lemna-species-exposed-to-four-herbicides
#20
Jihae Park, Murray T Brown, Stephen Depuydt, Jang K Kim, Dam-Soo Won, Taejun Han
An ecological impact assessment of four herbicides (atrazine, diuron, paraquat and simazine) was assessed using the aquatic floating vascular plants, Lemna gibba, Lemna minor and Lemna paucicostata as test organisms. The sensitivity of several ecologically relevant parameters (increase in frond area, root length after regrowth, maximum and effective quantum yield of PSII and maximum electron transport rate (ETRmax), were compared after a 72 h exposure to herbicides. The present test methods require relatively small sample volume (3 mL), shorter exposure times (72 h), simple and quick analytical procedures as compared with standard Lemna assays...
January 2017: Environmental Pollution
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