keyword
https://read.qxmd.com/read/33602156/one-year-outcomes-of-fixed-dosing-aflibercept-therapy-for-pre-treated-and-naive-polypoidal-choroidal-vasculopathy-patient
#21
JOURNAL ARTICLE
Hun Gu Choo, Jin Hae Lee, Hyun Sub Oh, Soon Hyun Kim, Yong Sung You, Oh Woong Kwon
BACKGROUND: Polypoidal choroidal vasculopathy (PCV) is a type of age-related macular degeneration that can cause permanent vision loss. The purpose of this paper was to report the one-year outcomes of fixed-dosing aflibercept therapy for the treatment of PCV. METHODS: This was a prospective, single-arm, interventional case series study of 25 PCV patients; 12 pre-treated and 13 treatment-naïve patients. The patients were treated and monitored for 12 months. Each patient was administered with an aflibercept (2...
February 18, 2021: BMC Ophthalmology
https://read.qxmd.com/read/33490277/rupture-risk-assessment-of-cervical-spinal-manipulations-on-carotid-atherosclerotic-plaque-by-a-3d-fluid-structure-interaction-model
#22
JOURNAL ARTICLE
Yili Chen, Shaoqun Zhang, Yang Chen, Yonghua Lao, Xuecheng Huang, Xiaoyu Huang, Qiming Liao, Yikai Li
Method: The FSI model, based on MRI data of an atherosclerosis patient, was used to simulate the deformations of the plaque and lumen during the process of two kinds of typical cSMT (the high-speed, low-amplitude spinal manipulation and the cervical rotatory manipulation). The biomechanical parameters were recorded, such as the highest wall shear stress (WSS), the maximum plaque wall stress (PWS), the wall tensile stress (Von mises stress, VWTS), and the strain. Result: The max_WSS was 33...
2021: BioMed Research International
https://read.qxmd.com/read/33328488/two-year-outcomes-of-the-treat-and-extend-regimen-using-aflibercept-for-treating-diabetic-macular-oedema
#23
JOURNAL ARTICLE
Yu Cheol Kim, Jae Pil Shin, Kang Yeun Pak, Hyun Woong Kim, Min Sagong, Sang Joon Lee, In Young Chung, Sung Who Park, Ji Eun Lee
This study was performed to investigate the efficacy of the treat-and-extend regimen using aflibercept for treating diabetic macular oedema (DME). This prospective, multicentre, interventional, single-arm, 104-week clinical trial included 48 patients with DME visual impairment. The patients' eyes received five consecutive intravitreal injections (2 mg aflibercept) every four weeks with two-week adjustments based on central subfield macular thickness (CSMT) changes. Injections were deferred when CSMT was stable...
December 16, 2020: Scientific Reports
https://read.qxmd.com/read/33307629/one-year-results-of-aflibercept-treatment-for-polypoidal-choroidal-vasculopathy-with-good-visual-acuity
#24
JOURNAL ARTICLE
Ji Min Kwon, Kang Yeun Pak, Jae Jung Lee, Min Sagong, Hyun Woong Kim
Purpose: To evaluate the one-year efficacy of intravitreal aflibercept injection in polypoidal choroidal vasculopathy (PCV) with best-corrected visual acuity (BCVA) of 20/40 or better. Methods: This was a multicenter retrospective study. The medical records of patients diagnosed with treatment-naïve PCV were retrospectively reviewed. Patients with an initial BCVA of 20/40 or better and who had undergone intravitreal aflibercept injection were included. Patients were treated with 3 consecutive monthly injections, followed by pro re nata regimen according to the clinician's discretion at variable interval visits...
December 11, 2020: Korean Journal of Ophthalmology: KJO
https://read.qxmd.com/read/33061272/cystoid-macular-edema-following-cataract-surgery-with-low-energy-femtosecond-laser-versus-conventional-phacoemulsification
#25
JOURNAL ARTICLE
Stefaan Van Nuffel, Matthias F Claeys, Marnix H Claeys
PURPOSE: To compare postoperative changes in central subfield macular thickness (CSMT) and prevalence of cystoid macular edema (CME) in patients undergoing cataract surgery with low-energy femtosecond laser versus standard phacoemulsification. DESIGN: This was a retrospective comparative real-world study. METHODS: Postoperative data of 252 eyes of 165 patients were collected: 138 eyes received low-energy femtosecond laser-assisted cataract surgery (FLACS) and 114 eyes underwent conventional phacoemulsification cataract surgery (CPCS)...
2020: Clinical Ophthalmology
https://read.qxmd.com/read/32967137/clinical-course-of-pseudophakic-cystoid-macular-edema-treated-with-nepafenac
#26
JOURNAL ARTICLE
Alexander Aaronson, Asaf Achiron, Raimo Tuuminen
BACKGROUND: To evaluate the clinical course of pseudophakic cystoid macular edema (PCME) treated with topical non-steroidal anti-inflammatory drugs (NSAIDs). METHODS: An analysis of the clinical course of PCME consisting of 536 eyes of 536 patients from five consecutive randomized clinical trials aimed at the optimization of anti-inflammatory medication in patients undergoing routine cataract surgery. PCME was classified as (i) grade 0a; no macular thickening, (ii) grade 0b; macular thickening (central subfield macular thickness (CSMT) increase of at least 10%) without signs of macular edema, (iii) grade I; subclinical PCME, (iv) grade II; acute PCME, (v) grade III; long-standing PCME...
September 21, 2020: Journal of Clinical Medicine
https://read.qxmd.com/read/32586117/four-year-outcomes-of-aflibercept-treatment-for-neovascular-age-related-macular-degeneration-results-from-real-life-setting
#27
JOURNAL ARTICLE
Marko Lukic, Maria Eleftheriadou, Robin D Hamilton, Ranjan Rajendram, Kajo Bucan, Praveen J Patel
BACKGROUND: To assess long-term structural and functional outcomes of intravitreal aflibercept (Eylea® ) treatment for neovascular macular degeneration (nAMD) in a real-word setting. DESIGN AND METHODS: This was a retrospective, single-centre, non-randomized interventional cohort analysis. Data from treatment-naive patients with nAMD funded for treatment with intravitreal aflibercept in the period between 1 September 2013 and 28 February 2014 and who finished 4-year follow-up entered the analysis...
June 25, 2020: European Journal of Ophthalmology
https://read.qxmd.com/read/32581240/clinical-characteristics-of-branch-retinal-vein-occlusion-with-increased-retinal-haemorrhage-during-treatment-for-macular-oedema
#28
JOURNAL ARTICLE
You Hyun Lee, Yu Cheol Kim
This study was performed to evaluate clinical characteristics of branch retinal vein occlusion (BRVO) patients with increased retinal haemorrhage during macular oedema (MO) treatment. Patients were divided into increased and non-increased retinal haemorrhage groups. The former group was sub-divided based on the degree of increase: < 50% or ≥ 50%. Baseline characteristics, clinical data, and best vision achieved before and after increased retinal haemorrhage were assessed. Sixty-eight eyes of 68 patients were included...
June 24, 2020: Scientific Reports
https://read.qxmd.com/read/31914437/one-year-results-of-treatment-of-diabetic-macular-edema-with-aflibercept-using-the-treat-and-extend-dosing-regimen-the-vibim-study
#29
JOURNAL ARTICLE
Kang Yeun Pak, Jae Pil Shin, Hyun Woong Kim, Min Sagong, Yu Cheol Kim, Sang Joon Lee, In Young Chung, Sung Who Park, Ji Eun Lee
INTRODUCTION: The purpose of this study was to report the one-year results of treatment of diabetic macular edema (DME) with aflibercept using a treat-and-extend regimen (TER). METHODS: This was a prospective, multicenter, single-arm study planned for 2 years. The eyes received 5 consecutive intravitreal injections of 2 mg of aflibercept every 4 weeks, and the interval between injections was then adjusted by 2 weeks based on changes in the central subfield macular thickness (CSMT)...
2020: Ophthalmologica. Journal International D'ophtalmologie
https://read.qxmd.com/read/31846122/controlled-saturation-magnetization-transfer-for-reproducible-multivendor-variable-flip-angle-t-1-and-t-2-mapping
#30
JOURNAL ARTICLE
Rui Pedro A G Teixeira, Radhouene Neji, Tobias C Wood, Ana A Baburamani, Shaihan J Malik, Joseph V Hajnal
PURPOSE: The widespread clinical application of quantitative MRI has been hindered by a lack of reproducibility across sites and vendors. Previous work has attributed this to incorrect B1 mapping or insufficient spoiling conditions. We recently proposed the controlled saturation magnetization transfer (CSMT) framework and hypothesized that the lack of reproducibility can also be attributed to magnetization transfer effects. This work seeks to validate this hypothesis and demonstrate that reproducible multivendor single-pool relaxometry can be achieved with the CSMT approach...
December 17, 2019: Magnetic Resonance in Medicine
https://read.qxmd.com/read/31656732/identification-of-the-metallothionein-gene-family-from-cucumber-and-functional-characterization-of-csmt4-in-escherichia-coli-under-salinity-and-osmotic-stress
#31
JOURNAL ARTICLE
Yong Zhou, Jialin Liu, Shiqiang Liu, Lunwei Jiang, Lifang Hu
Metallothionein (MT) proteins are low-molecular-weight, cysteine-rich and metal-binding proteins that play important roles in the maintenance of metal homeostasis and detoxification, but their roles in abiotic stress tolerance remain largely unknown. In this study, three MT family genes ( CsMT2 , CsMT3 and CsMT4 ) were identified in the cucumber genome. CsMT2, CsMT3 and CsMT4 possessed 14, 10, and 18 Cys residues, which were clustered into 2, 2, and 3 Cys-rich regions, respectively. Phylogenetic analysis of MTs from cucumber, Arabidopsis and soybean revealed that these MTs were clustered into four groups in accordance with the MT types (types 1-4)...
November 2019: 3 Biotech
https://read.qxmd.com/read/30736987/correlations-of-blood-lipids-with-early-changes-in-macular-thickness-in-patients-with-diabetes
#32
JOURNAL ARTICLE
J Liang, W Lei, J Cheng
PURPOSE: This study aimed to investigate the correlations of blood lipids with changes in macular volume and thickness in patients with diabetes. METHODS: Central subfield macular thickness (CSMT) and central subfield macular volume (CSMV) were measured in 85 patients with type 2 diabetes (DM2) using spectral-domain optical coherence tomography (SD-OCT). In addition, serum creatinine (Cr), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), glycated hemoglobin (HbA1c), and proteinuria were measured in all patients...
February 5, 2019: Journal Français D'ophtalmologie
https://read.qxmd.com/read/30620140/preoperative-anti-inflammatory-treatment-of-diabetic-patients-does-not-improve-recovery-from-cataract-surgery-when-postoperatively-treated-with-a-combination-of-prednisolone-acetate-and-nepafenac
#33
JOURNAL ARTICLE
Reeta Danni, Antti Viljanen, Alexander Aaronson, Raimo Tuuminen
PURPOSE: To examine preoperative anti-inflammatory treatment on recovery from cataract surgery in eyes of diabetic patients. METHODS: A Prospective randomized clinical trial. One hundred and three eyes of 103 patients with diabetes undergoing routine cataract surgery were randomized (1:1) not to receive any preoperative anti-inflammatory medication or to receive preoperative topical anti-inflammatory medication with a combination of prednisolone acetate (10 mg/ml) and nepafenac (1 mg/ml)...
January 8, 2019: Acta Ophthalmologica
https://read.qxmd.com/read/30581077/therapeutic-itinerary-of-children-living-with-epilepsy-in-kinshasa-features-determinants-and-relationships-with-behavioral-problems-and-cognitive-impairment
#34
JOURNAL ARTICLE
Thierry Matonda-Ma-Nzuzi, Samuel Mampunza Ma Miezi, Dominique Charlier-Mikolajczak, Diane Muanza Mvumbi, Fanny Malendakana, Glennie Eba Ntsambi, Junior Nsundi Mayemba, Davin Mbeya Mpaka, Magloire Nkosi Mpembi, Gilbert Mananga Lelo
BACKGROUND: Epilepsy mostly affects children in sub-Saharan Africa. However, little is known about the therapeutic itinerary of these children living with epilepsy (CWE). This study aimed to describe the therapeutic itinerary of CWE in Kinshasa and to analyze its relationships with clinical features, behavioral problems, and cognitive impairment. METHODS: This hospital-based study has included 104 CWE aged 6 to 17  years. The features of their therapeutic itinerary and their relationship with clinical features, behavioral problems, and cognitive impairment were analyzed...
January 2019: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/30257044/fast-quantitative-mri-using-controlled-saturation-magnetization-transfer
#35
JOURNAL ARTICLE
Rui Pedro A G Teixeira, Shaihan J Malik, Joseph V Hajnal
PURPOSE: This study demonstrates magnetization transfer (MT) effects directly affect relaxometry measurements and develops a framework that allows single-pool models to be valid in 2-pool MT systems. METHODS: A theoretical framework is developed in which a 2-pool MT system effectively behaves as a single-pool if the RMS RF magnetic field ( <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mi>B</mml:mi> <mml:mrow> <mml:mn>1</mml:mn> </mml:mrow> <mml:mrow> <mml:mi>rms</mml:mi> </mml:mrow> </mml:msubsup> </mml:math> {\text{B}}_{1}^{{{\text{rms}}}}) is kept fixed across all measurements...
September 14, 2018: Magnetic Resonance in Medicine
https://read.qxmd.com/read/30097432/racial-differences-and-determinants-of-macular-thickness-profiles-in-multiethnic-asian-population-the-singapore-epidemiology-of-eye-diseases-study
#36
JOURNAL ARTICLE
Kah Hie Wong, Yih-Chung Tham, Duc Quang Nguyen, Wei Dai, Nicholas Y Q Tan, Shivani Mathijia, Kumari Neelam, Carol Yim-Lui Cheung, Charumathi Sabanayagam, Leopold Schmetterer, Tien Yin Wong, Ching-Yu Cheng
AIM: To evaluate racial differences, and ocular and systemic determinants of macular thickness (MT), measured by spectral-domain optical coherence tomography (SD-OCT) in a normal multiethnic Asian population. METHOD: MT was measured from a 6×6 mm2 central macular area using the Cirrus high-definition OCT (HD-OCT) (Carl Zeiss Meditec, Dublin, CA). The associations between ocular and systemic factors with MT were evaluated using linear regression analyses with generalised estimating equation models to account for intereye correlation...
August 10, 2018: British Journal of Ophthalmology
https://read.qxmd.com/read/29982914/three-year-outcomes-of-aflibercept-treatment-for-neovascular-age-related-macular-degeneration-evidence-from-a-clinical-setting
#37
JOURNAL ARTICLE
Maria Eleftheriadou, Maria Gemenetzi, Marko Lukic, Sobha Sivaprasad, Philip G Hykin, Robin D Hamilton, Ranjan Rajendram, Adnan Tufail, Praveen J Patel
INTRODUCTION: To report 3-year treatment outcomes with intravitreal aflibercept injections for neovascular age-related macular degeneration (nAMD) in routine clinical practice. METHODS: This was a retrospective, single-centre, non-randomized interventional case series analysis. Data from treatment-naïve patients with nAMD treated between 1 October 2013 and 31 February 2014 were included in the analysis. Data including age, gender, vision acuity (VA) measured on Early Treatment of Diabetic Retinopathy Study charts (ETDRS) and injection numbers were recorded...
July 7, 2018: Ophthalmology and Therapy
https://read.qxmd.com/read/28926197/epiretinal-membrane-surgery-an-analysis-of-2-step-sequential-or-combined-phacovitrectomy-surgery-on-refraction-and-macular-anatomy-in-a-prospective-trial
#38
RANDOMIZED CONTROLLED TRIAL
Hassan Hamoudi, Ulrik Correll Christensen, Morten La Cour
PURPOSE: To assess the impact of combined phacoemulsification-vitrectomy and sequential surgery for idiopathic epiretinal membrane (ERM) on refractive error (RE) and macular morphology. METHODS: In this prospective clinical trial, we allocated phakic eyes with ERM to (1) cataract surgery and subsequent pars plana vitrectomy (PPV) (CAT group), (2) PPV and subsequent cataract surgery (VIT group) or (3) phaco-vitrectomy (COMBI group). Examinations were at baseline, one month after each surgery, and at 3 months and 12 months of follow-up...
May 2018: Acta Ophthalmologica
https://read.qxmd.com/read/28643714/comparison-of-vitrectomized-with-nonvitrectomized-eyes-after-subtenon-injection-of-triamcinolone-acetonide-to-treat-diabetic-macular-edema-retrospective-comparative-analysis-of-an-interventional-case-series
#39
COMPARATIVE STUDY
Kang Yeun Pak, Beom Seok Choi, Sung Who Park, Ik Soo Byon, Ji Eun Lee
PURPOSE: Triamcinolone acetonide (TA) is an alternative option for diabetic macular edema thanks to its cost-benefit ratio and unique delivery route. We performed this study to compare vitrectomized with nonvitrectomized eyes treated with subtenon TA injection for diabetic macular edema. MATERIALS AND METHODS: We retrospectively reviewed the medical records of patients who had undergone subtenon TA injection for diabetic macular edema treatment. The patients were divided into two groups: Vitrectomized and nonvitrectomized...
June 2017: Indian Journal of Ophthalmology
https://read.qxmd.com/read/28391536/plasma-homocysteine-levels-are-associated-with-macular-thickness-in-type-2-diabetes-without-diabetic-macular-edema
#40
JOURNAL ARTICLE
Ning Dong, Hong Shi, Xin Tang
PURPOSE: To explore the relationships between macular thickness and the plasma concentrations of homocysteine, vitamin B12, folate, and other known risk factors for patients with diabetes without diabetic macular edema (DME). METHODS: Fasting venous blood samples were collected from 252 subjects (126 relatively healthy subjects with type 2 diabetes without diabetic macular edema and 126 age- and gender-matched controls). Measurement of macular thickness and volume was performed for those subjects using SD-OCT...
April 2018: International Ophthalmology
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