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Luang Xu, Xinyu Liu, Na Sheng, Kyaw Soe Oo, Junxin Liang, Yok Hian Chionh, Juan Xu, Fuzhou Ye, Yong-Gui Gao, Peter C Dedon, Xin-Yuan Fu
Chemical RNA modifications are central features of epitranscriptomics, highlighted by the discovery of modified ribonucleosides in mRNA and exemplified by the critical roles of RNA modifications in normal physiology and disease. Despite a resurgent interest in these modifications, the biochemistry of 3-methylcytidine (m(3)C) formation in mammalian RNAs is still poorly understood. However, the recent discovery of trm141 as the second gene responsible for m(3)C presence in RNA in fission yeast raises the possibility that multiple enzymes are involved in m(3)C formation in mammals as well...
September 1, 2017: Journal of Biological Chemistry
Kosho Kinoshita, Mohammad Said Ashenagar, Masaki Tabuchi, Hideaki Higashino
Clarification of the genetic nature and more effective care for hypertension are required, given the high incidences of cardiovascular and cerebrovascular mortality. Thus, we surveyed candidate genes for hypertension with rat whole gene DNA microarrays using three novel methods. Gene expression analyses were conducted as follows: Method 1, three types of spontaneously hypertensive rat (SHR) substrains, SHR, stroke-prone SHR (SHRSP) and malignant type of SHRSP (M-SHRSP) were used and compared to normotensive Wistar Kyoto rats; Method 2, the expressed genes between rats of different ages were compared for different blood pressures; and Method 3, genes that were expressed in rats treated with or without an acute hypotensive stimulus, the antihypertensive hydralazine hydrochloride, were compared...
March 2011: Experimental and Therapeutic Medicine
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