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https://www.readbyqxmd.com/read/26231561/redesigning-a-general-education-science-course-to-promote-critical-thinking
#1
Matthew P Rowe, B Marcus Gillespie, Kevin R Harris, Steven D Koether, Li-Jen Y Shannon, Lori A Rose
Recent studies question the effectiveness of a traditional university curriculum in helping students improve their critical thinking and scientific literacy. We developed an introductory, general education (gen ed) science course to overcome both deficiencies. The course, titled Foundations of Science, differs from most gen ed science offerings in that it is interdisciplinary; emphasizes the nature of science along with, rather than primarily, the findings of science; incorporates case studies, such as the vaccine-autism controversy; teaches the basics of argumentation and logical fallacies; contrasts science with pseudoscience; and addresses psychological factors that might otherwise lead students to reject scientific ideas they find uncomfortable...
2015: CBE Life Sciences Education
https://www.readbyqxmd.com/read/22678932/rare-inherited-a2bp1-deletion-in-a-proband-with-autism-and-developmental-hemiparesis
#2
L K Davis, N Maltman, M W Mosconi, C Macmillan, L Schmitt, K Moore, S M Francis, S Jacob, J A Sweeney, E H Cook
Ataxin 2 binding protein 1 (A2BP1 aka FOX1, RBFOX1) is an RNA binding protein responsible for regulation of pre-mRNA splicing events in a number of critical developmental genes expressed in muscle, heart and neuronal cells [Shibata et al. (2000); Mamm Genome 12:595-601; Jin et al. (2003); EMBO J 22:905-912; Underwood et al. (2005); Mol Cell Biol 25:10005-10016]. Rare copy number abnormalities of A2BP1 have been previously associated with cognitive impairment, attention deficit disorder and autism [Martin et al...
July 2012: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/20615438/further-evidence-for-the-role-of-met-in-autism-susceptibility
#3
Ismail Thanseem, Kazuhiko Nakamura, Taishi Miyachi, Tomoko Toyota, Satoru Yamada, Masatsugu Tsujii, Kenji J Tsuchiya, Ayyappan Anitha, Yoshimi Iwayama, Kazuo Yamada, Eiji Hattori, Hideo Matsuzaki, Kaori Matsumoto, Yasuhide Iwata, Katsuaki Suzuki, Shiro Suda, Masayoshi Kawai, Gen-Ichi Sugihara, Kiyokazu Takebayashi, Noriyoshi Takei, Hironobu Ichikawa, Toshiro Sugiyama, Takeo Yoshikawa, Norio Mori
MET receptor tyrosine kinase (MET)-mediated signaling has been implicated in multiple aspects of neocortical and cerebellar neuronal growth and maturation. A promoter functional SNP (rs1858830) that disrupts the transcription of MET has been reported to be strongly associated with autism spectrum disorders (ASD) in the Caucasian population. Here, we performed a trio association study of MET with ASD in Japanese subjects (n=126 trios). Based on the HapMap data on the Japanese population, 15 SNPs were chosen for the association study...
October 2010: Neuroscience Research
https://www.readbyqxmd.com/read/18593506/genetic-and-expression-analyses-reveal-elevated-expression-of-syntaxin-1a-stx1a-in-high-functioning-autism
#4
Kazuhiko Nakamura, Ayyappan Anitha, Kazuo Yamada, Masatsugu Tsujii, Yoshimi Iwayama, Eiji Hattori, Tomoko Toyota, Shiro Suda, Noriyoshi Takei, Yasuhide Iwata, Katsuaki Suzuki, Hideo Matsuzaki, Masayoshi Kawai, Yoshimoto Sekine, Kenji J Tsuchiya, Gen-Ichi Sugihara, Yasuomi Ouchi, Toshiro Sugiyama, Takeo Yoshikawa, Norio Mori
Autism is a pervasive developmental disorder diagnosed in early childhood. Abnormalities of serotonergic neurotransmission have been reported in autism. Serotonin transporter (5-HTT), which modulates serotonin levels, is a major therapeutic target in autism. Therefore, factors that regulate 5-HTT expression might be implicated in autism. One candidate 5-HTT-regulatory protein is the presynaptic protein, syntaxin 1A (STX1A). We examined the association of STX1A with autism in a trio association study using DNA samples from 249 AGRE trios with autistic probands...
December 2008: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/18270976/genetic-analyses-of-roundabout-robo-axon-guidance-receptors-in-autism
#5
A Anitha, Kazuhiko Nakamura, Kazuo Yamada, Shiro Suda, Ismail Thanseem, Masatsugu Tsujii, Yoshimi Iwayama, Eiji Hattori, Tomoko Toyota, Taishi Miyachi, Yasuhide Iwata, Katsuaki Suzuki, Hideo Matsuzaki, Masayoshi Kawai, Yoshimoto Sekine, Kenji Tsuchiya, Gen-Ichi Sugihara, Yasuomi Ouchi, Toshiro Sugiyama, Keita Koizumi, Haruhiro Higashida, Nori Takei, Takeo Yoshikawa, Norio Mori
Autism is a pervasive developmental disorder diagnosed in early childhood. Abnormalities of serotonergic neurotransmission have been reported in autism. Serotonin transporter (SERT) modulates serotonin levels, and is a major therapeutic target in autism. Factors that regulate SERT expression might be implicated in the pathophysiology of autism. One candidate SERT regulatory protein is the roundabout axon guidance molecule, ROBO. SerT expression in Drosophila is regulated by robo; it plays a vital role in mammalian neurodevelopment also...
October 5, 2008: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/17626784/snp-analyses-of-growth-factor-genes-egf-tgfbeta-1-and-hgf-reveal-haplotypic-association-of-egf-with-autism
#6
Takao Toyoda, Kazuhiko Nakamura, Kazuo Yamada, Ismail Thanseem, Ayyappan Anitha, Shiro Suda, Masatsugu Tsujii, Yoshimi Iwayama, Eiji Hattori, Tomoko Toyota, Taishi Miyachi, Yasuhide Iwata, Katsuaki Suzuki, Hideo Matsuzaki, Masayoshi Kawai, Yoshimoto Sekine, Kenji Tsuchiya, Gen-ichi Sugihara, Yasuomi Ouchi, Toshiro Sugiyama, Nori Takei, Takeo Yoshikawa, Norio Mori
Autism is a pervasive neurodevelopmental disorder diagnosed in early childhood. Growth factors have been found to play a key role in the cellular differentiation and proliferation of the central and peripheral nervous systems. Epidermal growth factor (EGF) is detected in several regions of the developing and adult brain, where, it enhances the differentiation, maturation, and survival of a variety of neurons. Transforming growth factor-beta (TGFbeta) isoforms play an important role in neuronal survival, and the hepatocyte growth factor (HGF) has been shown to exhibit neurotrophic activity...
September 7, 2007: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/17354550/-autistic-psychopathy-or-pervasive-developmental-disorder-how-has-asperger-s-syndrome-changed-in-the-past-sixty-years
#7
REVIEW
Gen Ishikawa, Kayo Ichihashi
Bosch (1970) was the first author who used "Asperger's syndrome" in English literature. In those days, "Kanner's syndrome" i.e. autism, which had been under schizophrenic-versus-undeveloped arguments from the 1960's, was always contrasted with Asperger's "autistic psychopathy in children". From then on there have been vicissitudes over the notion of "Asperger's syndrome" and its clinical presentation. Nowadays, the restricted notion of "Asperger's syndrome" is dominant and used in both DSM-IV-TR and ICD-10...
March 2007: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/17349978/genetic-analyses-of-the-brain-derived-neurotrophic-factor-bdnf-gene-in-autism
#8
Katsuhiko Nishimura, Kazuhiko Nakamura, A Anitha, Kazuo Yamada, Masatsugu Tsujii, Yoshimi Iwayama, Eiji Hattori, Tomoko Toyota, Nori Takei, Taishi Miyachi, Yasuhide Iwata, Katsuaki Suzuki, Hideo Matsuzaki, Masayoshi Kawai, Yoshimoto Sekine, Kenji Tsuchiya, Gen-ichi Sugihara, Shiro Suda, Yasuomi Ouchi, Toshiro Sugiyama, Takeo Yoshikawa, Norio Mori
Autism is a severe neurodevelopmental disorder defined by social and communication deficits and ritualistic-repetitive behaviors that are detectable in early childhood. Brain-derived neurotrophic factor (BDNF) plays a critical role in the pathogenesis of autism. In this study, we examined the SNP- and haplotypic-association of BDNF with autism in a trios-based association study (the Autism Genetic Resource Exchange). We also examined the expression of BDNF mRNA in the peripheral blood lymphocytes of drug-naïve autism patients and control subjects...
April 27, 2007: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/17030376/decreased-serum-levels-of-transforming-growth-factor-beta1-in-patients-with-autism
#9
Kyoko Okada, Kenji Hashimoto, Yasuhide Iwata, Kazuhiko Nakamura, Masatsugu Tsujii, Kenji J Tsuchiya, Yoshimoto Sekine, Shiro Suda, Katsuaki Suzuki, Gen-ichi Sugihara, Hideo Matsuzaki, Toshiro Sugiyama, Masayoshi Kawai, Yoshio Minabe, Nori Takei, Norio Mori
BACKGROUND: The neurobiological basis for autism remains poorly understood. Given the key role of transforming growth factor-beta1 (TGF-beta1) in brain development, we hypothesized that TGF-beta1 plays a role in the pathophysiology of autism. In this study, we studied whether serum levels of TGF-beta1 are altered in patients with autism. METHODS: We measured serum levels of TGF-beta1 in 19 male adult patients with autism and 21 age-matched male healthy subjects using enzyme-linked immunosorbent assay (ELISA)...
January 30, 2007: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/16863675/increased-serum-levels-of-glutamate-in-adult-patients-with-autism
#10
Atsuko Shinohe, Kenji Hashimoto, Kazuhiko Nakamura, Masatsugu Tsujii, Yasuhide Iwata, Kenji J Tsuchiya, Yoshimoto Sekine, Shiro Suda, Katsuaki Suzuki, Gen-Ichi Sugihara, Hideo Matsuzaki, Yoshio Minabe, Toshiro Sugiyama, Masayoshi Kawai, Masaomi Iyo, Nori Takei, Norio Mori
BACKGROUND: Precise mechanisms underlying the pathophysiology of autism are currently unknown. Given the major role of glutamate in brain development, we have hypothesized that glutamatergic neurotransmission plays a role in the pathophysiology of autism. In this study, we studied whether amino acids (glutamate, glutamine, glycine, D-serine, and L-serine) related to glutamatergic neurotransmission are altered in serum of adult patients with autism. METHODS: We measured serum levels of amino acids in 18 male adult patients with autism and age-matched 19 male healthy subjects using high-performance liquid chromatography...
December 30, 2006: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/15219586/activation-of-the-fusiform-gyrus-when-individuals-with-autism-spectrum-disorder-view-faces
#11
Nouchine Hadjikhani, Robert M Joseph, Josh Snyder, Christopher F Chabris, Jill Clark, Shelly Steele, Lauren McGrath, Mark Vangel, Itzhak Aharon, Eric Feczko, Gordon J Harris, Helen Tager-Flusberg
Prior imaging studies have failed to show activation of the fusiform gyrus in response to emotionally neutral faces in individuals with autism spectrum disorder (ASD) [Critchley et al., Brain 124 (2001) 2059; Schultz et al., Arch. Gen. Psychiatry 57 (2000) 331]. However, individuals with ASD do not typically exhibit the striking behavioral deficits that might be expected to result from fusiform gyrus damage, such as those seen in prosopagnosia, and their deficits appear to extend well beyond face identification to include a wide range of impairments in social perceptual processing...
July 2004: NeuroImage
https://www.readbyqxmd.com/read/12208201/schizophrenia-and-other-mental-disorders-require-long-term-adoptive-immunotherapy
#12
Rudolf Wank
Many different microbial factors seem to contribute to the pathogenesis of schizophrenic and other psychiatric disorders. Activation of all T lymphocytes reactivates those downregulated by low-grade chronic infections and restores equilibrium in immune cell subpopulations. Different immune cell subpopulations express different neurotrophin receptors and produce different cytokines, particularly brain-derived neurotrophin (BDNF) and neurotrophin 3 (NT3) [M. Besser, R. Wank, J. Immunol. 162 (1998) 6303-6306] that appear to play a key role in schizophrenic and bipolar disorders [E...
August 2002: Medical Hypotheses
https://www.readbyqxmd.com/read/11055182/-genetic-studies-in-autistic-disorders
#13
REVIEW
A Słopień, A Rajewski
Since autism was first described by Leo Kanner the view on its etiology and pathogenesis has been changing. Recently there are more data on genetic and neurobiological background of autism. At the beginning it was noticed that autism appeared more frequently among boys, in population studies it was found that autism appeared more frequently among siblings, mostly among monozygotic twins. Many disorders like Tourett syndrome and tuberous sclerosis were reported in connection with autism. Recently research is focused mostly on chromosome abnormalities: chromosome 15 (locus 15q11-13), chromosome 7 (locus 7q), chromosome 16 (locus 16p) and gens of particular receptors (GABRB3, UBE3A/E6-AP, 5-HTT)...
May 2000: Psychiatria Polska
https://www.readbyqxmd.com/read/10507510/the-theory-of-an-agnosic-right-shift-gene-in-schizophrenia-and-autism
#14
M Annett
The right shift (RS) theory (Annett, M., 1972. The distribution of manual asymmetry. Br. J. Psychol. 63, 343-358; Annett, M., 1985. Left, Right, Hand and Brain: The Right Shift Theory. Lawrence Erlbaum, London) suggests that the typical pattern of human cerebral and manual asymmetries depends on a single gene (RS+) which impairs speech-related cortex of the right hemisphere. The theory offers solutions to several puzzles, including the distribution of handedness in families (Annett, M., 1978. A Single Gene Explanation of Right and Left Handedness and Brainedness...
October 19, 1999: Schizophrenia Research
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