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JOURNAL ARTICLE
Francisco Contreras-Ruston, Adrián Castillo-Allendes, Jorge Saavedra-Garrido, Andrés Felipe Ochoa-Muñoz, Eric J Hunter, Sonja A Kotz, Jordi Navarra
BACKGROUND: Individuals with Parkinson's Disease (IwPD) often fail to adjust their voice in different situations, without awareness of this limitation. Clinicians use self-report questionnaires that are typically designed for individuals with General Voice Disorders (GVD) in the vocal assessment of IwPD. However, these instruments may not consider that IwPD have a reduced self-perception of their vocal deficits. This study aimed to compare self-reported vocal symptoms and voice loudness between IwPD and GVD...
March 22, 2024: Parkinsonism & related Disorders
#2
JOURNAL ARTICLE
Bethany Ho, Ellen M Hong, Brian E Benson
INTRODUCTION: Health literacy, a strong indicator of health outcomes, is an important aspect of good patient care. With an increasing reliance on the Internet for health information, online patient materials should be easily understood by the average reader. The American Medical Association (AMA) and National Institutes of Health (NIH) recommend that patient education materials be written at a sixth-grade level. Creating effective digital information requires careful consideration of not only word choice, but also many other factors including actionability, comprehensiveness, evidence, and visual organization...
March 15, 2024: Journal of Voice
#3
JOURNAL ARTICLE
Richard Heyes, Charles Adler, Nan Zhang, Yassmeen Abdel-Aty, David G Lott, Stephen F Bansberg
OBJECTIVES: This study aims to evaluate the demographic differences between those with adductor spasmodic dysphonia with vocal tremor (AdSD(+)VT) and those without vocal tremor (AdSD(-)VT) and to analyze their response to treatment with botulinum neurotoxin (BoNT-A). STUDY DESIGN: Retrospective cohort study. METHODS: A database review of all spasmodic dysphonia patients treated with BoNT from 1989 to 2018 at the Mayo Clinic in Arizona was performed...
February 19, 2024: Journal of Voice
#4
REVIEW
Michela J Mir, Nicole E Herndon, Aparna Wagle Shukla, Karen Wheeler-Hegland, Nikolaus R McFarland
BACKGROUND: Early features of multiple system atrophy (MSA) are similar to those in Parkinson's disease (PD), which can challenge differential diagnosis. Identifying clinical markers that help distinguish MSA from forms of parkinsonism is essential to promptly implement the most appropriate management plan. In the context of a thorough neurological evaluation, the presence of a vocal flutter might be considered a potential feature of MSA-parkinsonian type (MSA-P). CASES: This case series describes clinical histories of 3 individuals with MSA-P...
February 5, 2024: Movement Disorders Clinical Practice
#5
JOURNAL ARTICLE
Brett Welch, Katherine Gold, Jackie Gartner-Schmidt, Andrej Petrov, Anthony Law, Leah B Helou
OBJECTIVES: Practitioners rely heavily on flexible endoscopic visualization of the true vocal folds during a repeated "sniff-ee" maneuver to assess vocal fold mobility. However, the human eye lacks the temporal and spatial precision required to accurately gauge fine differences in maximal glottal angle. This study compared differences in maximal glottal angle variables during "sniff-ee" maneuvers across patients with various voice and laryngeal breathing disorders. METHODS: We retrospectively measured glottal angle from flexible laryngoscopy examinations in six groups of patients with voice and upper airway disorders: laryngeal dystonia/essential tremor (LD/ET), vocal fold lesions, vocal fold atrophy, paradoxical vocal fold motion disorder (PVFMD), muscle tension dysphonia (MTD), and healthy controls...
January 8, 2024: Journal of Voice
#6
JOURNAL ARTICLE
Daisuke Sato, Hiroyasu Sato, Toshiyuki Kondo, Ryosuke Igari, Chifumi Iseki, Hikaru Kawahara, Shintaro Amano, Yoya Ono, Akio Kimura, Takayoshi Shimohata, Yasuyuki Ohta
Anti-IgLON5 disease shows various neurological manifestations, of which dysautonomia is one of the major symptoms and is rarely improved by immunotherapy. We herein report a patient with anti-IgLON5 disease who showed several autonomic failures, including vocal cord palsy for four months. The patient presented with cognitive impairments, bulbar symptoms accompanied by myorhythmia in the pharynx and tongue, cerebellar ataxia with tremor, motor neuron symptoms in the limbs, gastrointestinal dysfunction, orthostatic hypotension, non-rapid eye movement sleep disorder on polysomnography, and severe vocal cord palsy...
January 2, 2024: Internal Medicine
#7
JOURNAL ARTICLE
Richard Heyes, Charles H Adler, Claire Yee, David G Lott, William E Karle
OBJECTIVES: There is an absence of data in the literature regarding methods to improve the patient experience during the performance of awake in-office laryngeal injections. This study sought to evaluate whether the use of local anesthetic or a vibrating instrument decreased overall pain experienced by patients with laryngeal dystonia, frequently referred to as spasmodic dysphonia (SD), undergoing transcervical botulinum toxin injections. METHODS: This was an unblinded, prospective randomized control trial with a crossover design where each patient received transcutaneous transcricothyroid injection of botulinum toxin with alternating use of no anesthesia, local anesthesia (2% lidocaine in 1:100,000 epinephrine), and vibrating instrument in three consecutive laryngeal injections to treat adductor SD...
December 29, 2023: Laryngoscope
#8
JOURNAL ARTICLE
João Viana Pinto, Susana Santiago Pérez, Isabel Garcia-Lopez
OBJECTIVE: The main objective of this study was to compare the demographic and clinical characteristics of patients with laryngeal dystonia (LD), dystonic tremor (DT), and vocal tremor (VT). STUDY DESIGN: This was a retrospective longitudinal study. METHODS: Data analysis from every patient diagnosed with LD, DT, or VT from January 1, 2010, to September 30, 2022, at a tertiary hospital center. Differential diagnosis between these entities was clinical (clinical history, voice assessment, and endoscopy) and confirmed by laryngeal electromyography...
December 27, 2023: Journal of Voice
#9
JOURNAL ARTICLE
Sukanya Pechetti, Battula Srinivasa Rao
BACKGROUND AND OBJECTIVE: Parkinson's disease (PD) is a progressive neurological condition that manifests motor and non-motor symptoms. Early in the course of the disease, PD patients frequently experience vocal difficulties. In the beginning, preprocessing procedures were used with multi-focus image fusion to enhance the quality of input images. It is essential to diagnose and treat PD early to ensure that patients live healthy and productive lives. METHODS: Tremors, rigidity in the muscles, slow movement, difficulty balance, and other psychological symptoms are some of the disease's symptoms...
2023: PeerJ. Computer Science
#10
JOURNAL ARTICLE
John J Pearce, Jaclyn Thoma, Kimberly Vinson, Sepehr Sani
BACKGROUND: Essential vocal tremor is a difficult disease entity to treat with a poor response to existing medical management and limited options for surgical management of the disease. Magnetic resonance imaging-guided focused ultrasound (MRgFUS) is an emerging treatment modality with encouraging results for limb tremor in patients with essential tremor, but data are limited for the treatment of vocal tremor. OBSERVATIONS: This is the case of a 69-year-old male with a history of essential vocal tremor severely limiting his ability to perform his occupation as an opera singer...
June 26, 2023: J Neurosurg Case Lessons
#11
JOURNAL ARTICLE
Nayanika Ghosh, Elizabeth Eidson, Elaina Derrick, Rosemary A Lester-Smith
OBJECTIVE: Essential vocal tremor (EVT) manifests as nearly rhythmic modulations of fundamental frequency (fo ) and intensity and causes a shaky voice. Although research on behavioral therapy for EVT is limited, previous studies have shown that a breathy voice reduces the perception of simulated EVT and might be an effective compensatory strategy. The current study aimed to measure the acoustical and perceptual effects of a breathy voice strategy in speakers with EVT. STUDY DESIGN: A single-case experimental design (SCED) was used to investigate acoustical effects, and a pair comparison listening task was used to investigate perceptual effects...
November 24, 2023: Journal of Voice
#12
REVIEW
Susan Price, Todd M Ruppar
BACKGROUND: Ketogenic therapies have shown benefit for seizure reduction in epilepsy but their impact on other neurologic conditions is less known. In this literature review, the efficacy of ketogenic therapies were assessed in Parkinson's disease (PD), Alzheimer's disease (AD), and mild cognitive impairment (MCI). METHODS: A literature search was conducted using PubMed, Scopus, and Google Scholar focusing on ketogenic therapies in PD, AD, and MCI. RESULTS: A total of 2565 records were identified with a total of 15 studies (3 for PD and 12 for MCI/AD) meeting criteria for analysis...
December 2023: Applied Nursing Research: ANR
#13
JOURNAL ARTICLE
Rauan Kaiyrzhanov, Aboulfazl Rad, Sheng-Jia Lin, Aida Bertoli-Avella, Wouter W Kallemeijn, Annie Godwin, Maha S Zaki, Kevin Huang, Tracy Lau, Cassidy Petree, Stephanie Efthymiou, Ehsan Ghayoor Karimiani, Maja Hempel, Elizabeth A Normand, Sabine Rudnik-Schöneborn, Ulrich A Schatz, Marc P Baggelaar, Muhammad Ilyas, Tipu Sultan, Javeria Raza Alvi, Manizha Ganieva, Ben Fowler, Ruxandra Aanicai, Gulsen Akay Tayfun, Abdulaziz Al Saman, Abdulrahman Alswaid, Nafise Amiri, Nilufar Asilova, Vorasuk Shotelersuk, Patra Yeetong, Matloob Azam, Meisam Babaei, Gholamreza Bahrami Monajemi, Pouria Mohammadi, Saeed Samie, Selina Husna Banu, Jorge Pinto Basto, Fanny Kortüm, Mislen Bauer, Peter Bauer, Christian Beetz, Masoud Garshasbi, Awatif Hameed Issa, Wafaa Eyaid, Hind Ahmed, Narges Hashemi, Kazem Hassanpour, Isabella Herman, Sherozjon Ibrohimov, Ban A Abdul-Majeed, Maria Imdad, Maksudjon Isrofilov, Qassem Kaiyal, Suliman Khan, Brian Kirmse, Janet Koster, Charles Marques Lourenço, Tadahiro Mitani, Oana Moldovan, David Murphy, Maryam Najafi, Davut Pehlivan, Maria Eugenia Rocha, Vincenzo Salpietro, Miriam Schmidts, Adel Shalata, Mohammad Mahroum, Jawabreh Kassem Talbeya, Robert W Taylor, Dayana Vazquez, Annalisa Vetro, Hans R Waterham, Mashaya Zaman, Tina A Schrader, Wendy K Chung, Renzo Guerrini, James R Lupski, Joseph Gleeson, Mohnish Suri, Yalda Jamshidi, Kailash P Bhatia, Barbara Vona, Michael Schrader, Mariasavina Severino, Matthew Guille, Edward W Tate, Gaurav K Varshney, Henry Houlden, Reza Maroofian
The acyl-CoA-binding domain-containing protein 6 (ACBD6) is ubiquitously expressed, plays a role in the acylation of lipids and proteins, and regulates the N-myristoylation of proteins via N-myristoyltransferase enzymes (NMTs). However, its precise function in cells is still unclear, as is the consequence of ACBD6 defects on human pathophysiology. Utilizing exome sequencing and extensive international data sharing efforts, we identified 45 affected individuals from 28 unrelated families (consanguinity 93%) with bi-allelic pathogenic, predominantly loss-of-function (18/20) variants in ACBD6...
November 10, 2023: Brain
#14
JOURNAL ARTICLE
Rosa Delia Ramírez Ruiz, Mariam Quintillá, Marta Sandoval, Lucía León, Jose Miguel Costa, Miquel Quer
PURPOSE: This study evaluates expert opinion on laryngeal electromyography (LEMG). METHODS: A cross-sectional design was used to conduct an online survey of LEMG experts in 2021. They were questioned about the number LEMG performed annually, type of electrodes used, sector worked in, pain during the test, placement of the needle electrodes, interpretation of electrical muscle parameters, diagnosis of neuromuscular injury, prognostic sensitivity in vocal fold paralysis (VFP), laryngeal dystonia, tremor and synkinesis and quantifying LEMG...
October 30, 2023: Acta otorrinolaringologica española
#15
JOURNAL ARTICLE
Myung Jin Ban, Chang Hwan Ryu, Joo Hyun Woo, Young Chan Lee, Dong Kun Lee, Minsu Kwon, Yong Tae Hong, Gil Joon Lee, Seung Ho Choi, Hyung Kwon Byeon, Seung-Won Lee
The Korean Society of Laryngology, Phoniatrics and Logopedics set a task force to establish clinical practice guidelines for the use of botulinum toxin (BT) in the otolaryngology field. We selected ten disease categories: spasmodic dysphonia, essential vocal tremor, vocal fold granuloma, bilateral vocal fold paralysis, Frey's syndrome, sialocele, sialorrhea, cricopharyngeal dysfunction, chronic sialadenitis, and first bite syndrome. To retrieve all relevant papers, we searched the CORE databases with predefined search strategies, including Medline (PubMed), Embase, the Cochrane Library, and KoreaMed...
October 25, 2023: Clinical and Experimental Otorhinolaryngology
#16
REVIEW
Feiao Lu, Kun Zhao, Yulun Wu, Yurou Kong, Yongxiang Gao, Liya Zhang
OBJECTIVES: The effectiveness of deep brain stimulation (DBS) in treating vocal tremors is currently a subject of debate. To assess the efficacy of DBS therapy in adults with vocal tremors (VT), we analyzed its impact on voice tremor severity, voice-related quality of life, fundamental frequency, voice intensity, and emotional state. METHODS: We conducted a systematic review with meta-analysis to investigate the impact of DBS therapy on voice tremor severity, voice-related quality of life, fundamental frequency, voice intensity, and emotional state in adults with vocal tremors (PROSPERO/CRD42023420272)...
October 23, 2023: Journal of Voice
#17
JOURNAL ARTICLE
Yu Yao, Maria Powell, Jules White, Jian Feng, Quchen Fu, Peng Zhang, Douglas C Schmidt
BACKGROUND: It remains hard to directly apply deep learning-based methods to assist diagnosing essential tremor of voice (ETV) and abductor and adductor spasmodic dysphonia (ABSD and ADSD). One of the main challenges is that, as a class of rare laryngeal movement disorders (LMDs), there are limited available databases to be investigated. Another worthy explored research question is which above sub-disorder benefits most from diagnosis based on sustained phonations. The question is from the fact that sustained phonations can help detect pathological voice from healthy voice...
September 29, 2023: Computers in Biology and Medicine
#18
JOURNAL ARTICLE
Padraig O'Suilleabhain, Diane S Berry, Duane A Lundervold, Travis H Turner, Madeline Tovar, Elan D Louis
BACKGROUND: People with essential tremor (ET) can be subject to stigma, and some adopt avoidance behaviors. Characteristics associated with ET stigma and the relationship between perceived stigma and social dysfunction have not been studied. OBJECTIVES: To discern predictors of perceived stigma and social dysfunction in ET, and to identify potentially treatable psychological factors associated with social dysfunction. METHODS: We surveyed ET patients ( n = 158) on recalled stigma incidents and social dysfunction related to tremor, as well as clinical and demographic characteristics including tremor severity, and psychological constructs including anxiety, depression, mindfulness, resilience, and narcissism...
September 2023: Movement Disorders Clinical Practice
#19
JOURNAL ARTICLE
Tomoe Sato, Rie Saito, Makoto Sainouchi, Naomi Mezaki, Takeshi Miura, Takuya Mashima, Akiyoshi Kakita
A 74-year-old male patient developed multiple infarcts of the brainstem and cerebellum, followed 14 months later by palatal tremor and bilateral vocal cord abduction paralysis, resulting in death due to type 2 respiratory failure. Pathologic analysis revealed old infarcts extending from the bilateral cerebellar cortices to the dentate nucleus, being more extensive on the right side, accompanied by Wallerian degeneration involving the left red nucleus, right central tegmentum tract, and inferior cerebellar peduncle, followed by pseudohypertrophy of the bilateral inferior olivary nuclei...
August 29, 2023: Rinshō Shinkeigaku, Clinical Neurology
#20
JOURNAL ARTICLE
Rahul Nijhawan, Mukul Kumar, Sahitya Arya, Neha Mendirtta, Sunil Kumar, S K Towfek, Doaa Sami Khafaga, Hend K Alkahtani, Abdelaziz A Abdelhamid
Parkinson's disease (PD) affects a large proportion of elderly people. Symptoms include tremors, slow movement, rigid muscles, and trouble speaking. With the aging of the developed world's population, this number is expected to rise. The early detection of PD and avoiding its severe consequences require a precise and efficient system. Our goal is to create an accurate AI model that can identify PD using human voices. We developed a transformer-based method for detecting PD by retrieving dysphonia measures from a subject's voice recording...
August 7, 2023: Biomimetics
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