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Vijay K Karra, Soumya J Chowdhury, Rajesh Ruttala, Sunil K Polipalli, Premashis Kar
BACKGROUND/OBJECTIVE: Quantification of serum hepatitis B antigen (HBsAg) is an important test that marks active infection with hepatitis B and helps in the prediction of the clinical outcome and management of hepatitis B virus (HBV) infection. Correlation with HBV DNA quantitative levels may help in developing strategies for antiviral treatment. This study is aimed to evaluate HBsAg titres in various phase of HBV infection in HBsAg positive patients, and its correlation with HBV DNA viral load levels...
September 2016: Journal of Clinical and Experimental Hepatology
Simmi K Ratan, Anju Sharma, Seema Kapoor, Sunil K Polipalli, Divya Dubey, Tarun K Mishra, Shandip K Sinha, Satish K Agarwal
OBJECTIVE: To study MAMLD1 gene polymorphisms, serum LH and testosterone levels amongst Indian children with isolated hypospadias (IH) and controls. MATERIALS AND METHODS: Screening of the MAMLD1 gene was performed by PCR sequencing method in 100 Indian children aged 0-12 years presenting with IH and 100 controls. LH and testosterone hormone levels were also assessed (categorized in four age-wise groups). RESULTS: IH subjects had significantly higher incidence of MAMLD1 polymorphism as compared to controls (33 vs 15 %, p = 0...
May 2016: Pediatric Surgery International
Cristiano Rossitto, Salvatore Gueli Alletti, Barbara Costantini, Francesco Fanfani, Giovanni Scambia
STUDY OBJECTIVE: To highlight the first case of laparoscopic hysterectomy performed with percutaneous instruments (The Percuvance System, Teleflex Incorporated, Wayne, PA). DESIGN: The basis of the system is a <3-mm diameter shaft that, when connected to an introducer tool tip, can be inserted percutaneously through the skin. The introducer tool tip can then be exchanged outside the body for a wide variety of 5-mm interchangeable surgical tool tips. The shaft is sufficiently strong to hold structures, and surgeons can use its interchangeable tool tips to grasp, cut, and manipulate tissue...
January 2016: Journal of Minimally Invasive Gynecology
Vijay Kumar Karra, Phani Kumar Gumma, Soumya Jyoti Chowdhury, Rajesh Ruttala, Sunil Kumar Polipalli, Anita Chakravarti, Premashis Kar
Interleukine-18 (IL-18) was originally called interferon (INF-γ) inducing factor and plays a critical dual role in Th1 polarization and viral clearance. We aimed to explore whether single-nucleotide promoter polymorphisms (SNPs) are associated with the outcome of hepatitis B virus (HBV) infection. 271 HBV infected patients were recruited in this study out of these 109 were spontaneously recovered and 162 were diagnosed to be having persistent HBV infection which includes 48 chronic hepatitis, 84 liver cirrhosis, 30 HCC cases and were compared with 280 healthy controls...
June 2015: Cytokine
Varun Chaithanya Gurram, Sunil Kumar Polipalli, Vijay Kumar Karra, Madhavi Puppala, Sanjeev Kumar Pandey, Seema Kapoor, Ashok Kumar, Sudhakar Godi
BACKGROUND: Interleukin-18 (IL-18) is a pro inflammatory cytokine which plays a key role in the acute and chronic inflammatory phases of Rheumatoid Arthritis (RA). The Single Nucleotide Polymorphisms (SNPs) of IL-18 gene promoter region at positions -137 and -607, are postulated to be associated with RA. To test this, this study aimed to identify the association between these SNPs of the IL-18 gene promoter region of RA in south Indian patients. MATERIALS AND METHODS: This study was carried on 190 subjects among which 90 were RA patients and 100 were age and sex matched controls...
June 2014: Journal of Clinical and Diagnostic Research: JCDR
Sanjeev Kumar Pandey, Ankur Singh, Sunil Kumar Polipalli, Sangeeta Gupta, Seema Kapoor
BACKGROUND AND AIM: Osteoporosis (OP) is a common nutrigenomic disease associated with various genetic components. Observational studies have indicated that mildly elevated homocysteine was a strong risk factor for osteoporotic fractures. Yet there is no clear biologic mechanism for an effect of homocysteine on bone.The aim of this study was to investigate the association of MTHFR C677T and A1298C polymorphisms, and to verify the association of these polymorphisms with bone mineral density and homocysteine in premenopausal women of northern India...
December 2013: Journal of Clinical and Diagnostic Research: JCDR
Pankaj K Mohanty, Seema Kapoor, Anand P Dubey, Sanjeev Pandey, Renuka Shah, Hemant K Nayak, Sunil K Polipalli
AIMS AND OBJECTIVE: Evaluation of C677T polymorphisms of the methylenetetra hydrofolate reductase (MTHFR) gene and its association with level of serum homocysteine, folate, and vitamin B12 as possible maternal risk factors for Down syndrome. DESIGN: This was a case-control study. MATERIAL AND METHODS: Fifty-two mothers (mean age 27.6 years) with babies having free trisomy 21 of North Indian ethnicity and 52 control nonlactating mothers (mean age 24...
September 2012: Indian Journal of Human Genetics
L Alecu, A Tulin, Beatrice Ursut, B Ursut, A Oproiu, F Obrocea
Duodenal tumors are very rare tumors, with the lower incidence among the tumors of the small bowel, whose frequence is less than 5 % of all digestive tumors. In most of the cases these tumors remain asymptomatic, sometimes the entire life. When they become symptomatic, their first manifestation is the loss of digested blood (melena), secondary anemia and obstructive symptomatology. Early diagnosis of these tumors is difficult because of the unsystematic symptomatology and becomes easy when the complications appear...
March 2012: Chirurgia
Nargis Begum, Sunil K Polipalli, Syed A Husain, Premashis Kar
BACKGROUND & OBJECTIVES: Hepatitis E is the main cause of enterically transmitted non-A, non-B hepatitis in developing countries. In the developed countries such as the USA, Japan and Taiwan, the viruses infecting humans and swine share the same genotype with a high sequence similarity. Genotype 1 circulates in humans whereas genotype 4 in pigs in India. The present study was designed to investigate the presence of anti-HEV antibodies and HEV-RNA in swine population from north India, to investigate the genotype prevalent in it, and to compare it with other swine and human HEV strains from India...
November 2010: Indian Journal of Medical Research
Mohammad Asim, Abdul Malik, Manash P Sarma, Sunil K Polipalli, Nargis Begum, Istaq Ahmad, Luqman A Khan, S A Husain, Naseem Akhtar, Sajid Husain, L Thayumanavan, Rajiv Singla, P Kar
The study aims to characterize mutations of the HBV genome involving BCP, Precore/core and X regions and also defines HBV genotypes in patients of hepatocellular carcinoma (HCC). The study involved 150 HBV-related HCC cases and 136 HBV-related chronic liver disease patients without HCC as controls. HBV DNA was subjected to mutational analysis using SSCP technique, genotyping by RFLP, and direct nucleotide sequencing. HBV DNA was found in 58.7% (88/150) of the HCC cases and 74.3% (101/136) of controls. HBV mutants were observed in 44...
July 2010: Journal of Medical Virology
Nargis Begum, Sunil Kumar Polipalli, Syed Akhtar Husain, Ashok Kumar, Premashis Kar
OBJECTIVE: To investigate the duration of hepatitis E virus (HEV) infection in pregnant and non-pregnant women with acute viral hepatitis (AVH) or fulminant hepatic failure (FHF). METHODS: A prospective study conducted with 20 pregnant women with AVH, 20 non-pregnant women with AVH, 10 pregnant women with FHF, and 9 non-pregnant women with FHF-all with HEV infection. The women were followed up on day 7, 15, 30, 60, and 90 following recruitment for the presence of HEV-RNA...
March 2010: International Journal of Gynaecology and Obstetrics
Daniela Mielcarek-Kuchta, Małgorzata Leszczyńska, Witold Szyfter, Romuald Wielgosz, Tomasz Pastusiak
INTRODUCTION: In this work we wish to emphasize the importance of postoperative care of patients who underwent FESS in ENT Department Medical University in Poznań. We feel that too little attention is still being paid to this treatment as we mostly focus on surgery. MATERIAL AND METHODS: Our observation are based on nine year experience in functional endoscopic sinus surgery. The analysis covers patients hospitalized in our Department from January 1998 to August 2007...
2008: Otolaryngologia Polska. the Polish Otolaryngology
Daniel Paczesny, Piotr Rapiejko, Jerzy Weremczuk, Ryszard Jachowicz, Dariusz Jurkiewicz
AIM: Aim of this study was to check at the hospital the electronic thermometer for fast measurement of air temperature in upper airways. The nose ability of heating of inspired air and heat recovering from expired air was evaluated. Measurements from respiration through the oral cavity were compared. MATERIAL AND METHODS: The study was carried out in a group of 30 people (6 female and 24 male), age group 18 to 62 (mean age: 33.5 years old). Almost the half of participants had no deviation from normal state in laryngologic examination...
2007: Otolaryngologia Polska. the Polish Otolaryngology
Subhash Medhi, Sai K Potukuchi, Sunil K Polipalli, Shyam S Swargiary, Purabi Deka, Anis Chaudhary, Anish Choudhary, Nargis Begum, Zahid Hussain, R S Ahlawat, Premashis Kar
BACKGROUND: Patients undergoing hemodialysis are at high risk for Hepatitis C virus infection. Anti-HCV antibody detection is widely used for screening this infection but is not sensitive for window period detection. An ELISA to detect the HCV Core Antigen has recently become available. OBJECTIVES: To investigate the utility of the HCV core Antigen ELISA in the detection of HCV infection in hemodialysis patients and to compare with 3rd generation ELISA validated by real-time PCR...
May 2008: Clinical Biochemistry
Daniel Paczesny, Piotr Rapiejko, Jerzy Weremczuk, Ryszard Jachowicz, Dariusz Jurkiewicz
AIM: Aim of this study was to check at the hospital the dew point hygrometer for fast measurement of air humidity in upper airways. The nose ability to humidification of inspired air and partially recover moisture from expired air was evaluated. Measurements from respiration through the nose and oral cavity were compared. MATERIAL AND METHODS: The study was carried out in a group of 30 people (8 female and 22 male), age group 18 to 70 (mean age: 37 years old). In 22 of the participants there were no deviation from normal state in laryngologic examination, while in 4 participants nasal septum deviation without imaired nasal; oatency was found, in other 3--nasal vonchae hyperthrophy and in 1--nasal polips (grade I)...
2007: Otolaryngologia Polska. the Polish Otolaryngology
I Lavín Castejón, J Mut Oltra, C Trillo Balizón, A Maldonado Barrionuevo
Cowden's disease is a rare genodermatosis that is characterized for multiple cutaneous and visceral hamartoma . Lhermitte-Duclos's disease is a cerebelous lesion that consists in the displasic enlargement of the cerebelous circumvolution. It's incluyed in phacomatosis and usually presents associated to Cowden's disease, tuberous sclerosis and overlap syndromes.A 56 years old man, diagnosed in Dermatology with Cowden's disease ten years ago. In the extension study, he had hamartoma intestinal polip, esophagic glucogenic acanthosis and two solid thyroid nodules...
May 2007: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
Zahid Hussain, Syed A Husain, Syed T Pasha, Ranjana Anand, Abdullah Chand, Sunil K Polipalli, Shabeena Rehman, Premashis Kar
BACKGROUND: Human hepatitis A, a widespread infectious disease that is hyperendemic in vast areas of the world, results in the infection of the liver. Different human HAV strains of diverse geographic origin are remarkably closely related. HAV exploits all known mechanisms of genetic variation to ensure survival, including mutation and genetic recombination. OBJECTIVES: The aim of the study was to undertake an in-depth analysis of the mutation in three groups: (i) mild acute hepatitis (m-AH), (ii) severe acute hepatitis (s-AH), and (iii) fulminant hepatitis (FHF) A patients, who were tested positive for HAV RNA...
February 2008: Digestive Diseases and Sciences
V N Sotnikov, T K Dubinskaia, A V Sotnikov, N V Ageĭkina, L A Margarian, Kh Kh Vyshegurov
Out of 3243 patients with gastric polips, polyposis was diagnosed in 298 ones including 135 cases of complicated and 163 cases of uncomplicated forms. Hyperplastic polips were diagnosed in 281 patients. Along with hyperplastic polyps, solitary adenomas were diagnosed in 9 cases, Peitz-Jegerc polyps - in 6, and juvenile polyps - in 2. Polypectomy was performed in 153 patients: partial - in 104, and total - in 49. Follow-up was carried out in 98 non-operated patients, indications for endoscopic surgery were seen in 18 cases...
2007: Khirurgiia
Premashis Kar, Sunil K Polipalli, Saket Chattopadhyay, Zahid Hussain, Abdul Malik, Syed A Husain, Subhash Medhi, Nargis Begum
Hepatitis B is one of the most important causes of chronic viral hepatitis world wide. Mutations in the precore region of the hepatitis B virus (HBV) genome are frequently found in hepatitis B envelope antigen-negative cases. Data from India on the HBV genotype-associated distribution of precore mutations are limited. Our objective in this study was to genotype and detect the precore mutant with a point mutation from G to A at nucleotide 1896 using ligase chain reaction (LCR) and direct sequencing. A total of 115 cases of chronic liver disease were screened...
February 2007: Digestive Diseases and Sciences
Zahid Hussain, Bhudev C Das, Syed A Husain, Sunil K Polipalli, Tanzeel Ahmed, Nargis Begum, Subhash Medhi, Alice Verghese, Mohammad Raish, Apiradee Theamboonlers, Yong Poovorawan, Premashis Kar
AIM: To undertake analysis of hepatitis A viral load, alanine aminotransferase (ALT), and viral genotypes with duration of viremia, and to correlate these parameters with CD4(+)/ CD8(+) lymphocyte populations that control cell-mediated immunity. METHODS: Cell counts were carried out using fresh whole blood collected in EDTA vials using a fluorescence activated cell sorter. Hepatitis A virus (HAV) RNA was extracted from blood serum, reverse transcribed into cDNA and quantified by Real-Time polymerase chain reaction and was genotyped...
August 7, 2006: World Journal of Gastroenterology: WJG
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