D Reglodi, P Kiss, K Szabadfi, T Atlasz, R Gabriel, G Horvath, P Szakaly, B Sandor, A Lubics, E Laszlo, J Farkas, A Matkovits, R Brubel, H Hashimoto, A Ferencz, A Vincze, Z Helyes, L Welke, A Lakatos, A Tamas
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a widespread neuropeptide with a diverse array of biological functions. Not surprisingly, the lack of endogenous PACAP therefore results in a variety of abnormalities. One of the important effects of PACAP is its neuroprotective and general cytoprotective role. PACAP protects neurons and other tissues against ischemic, toxic, and traumatic lesions. Data obtained from PACAP-deficient mice provide evidence that endogenous PACAP also has protective functions...
November 2012: Journal of Molecular Neuroscience: MN