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https://www.readbyqxmd.com/read/27446327/severe-adverse-reactions-caused-by-omeprazole-a-case-report
#1
Meiling Yu, Jianghua Qian, Daohua Guo, Li Li, Xiaolin Liu
A 61-year-old female patient was admitted to hospital following development of a whole-body rash for 10 days, diarrhea for 7 days, and unconsciousness and oliguria for 1 day. The patient had developed stomach discomfort following the oral administration of non-steroidal anti-inflammatory drugs, the exact nature of which was unknown, for the treatment of arthritic pain for >1 month. The patient was then prescribed omeprazole enteric-coated tablets (20 mg twice daily) for treatment of this symptom. However, the patient developed a whole-body rash 7 days after administering omeprazole, 10 days prior to admission...
August 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27393154/mtorc2-signaling-regulates-nox4-induced-podocyte-depletion-in-diabetes
#2
Stephanie Eid, Suzan Boutary, Kawthar Braysh, Ramzi Sabra, Charbel Massaad, Ahmed Hamdy, Awad Rashed, Sarah Moodad, Karen Block, Yves Gorin, Hanna E Abboud, Assaad Antoine Eid
AIM: Podocyte apoptosis is a critical mechanism for excessive loss of urinary albumin that eventuates in kidney fibrosis. Oxidative stress plays a critical role in hyperglycemia-induced glomerular injury. We explored the hypothesis that mTORC2 mediates podocyte injury in diabetes. RESULTS: High glucose (HG) induces podocyte injury reflected by alteration in the slit diaphragm protein podocin and podocyte depletion/apoptosis. This was paralleled by activation of the Rictor/mTORC2/Akt pathway...
July 8, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27296391/scrub-typhus-in-a-tertiary-care-hospital-in-north-india
#3
Navneet Sharma, Manisha Biswal, Abhay Kumar, Kamran Zaman, Sanjay Jain, Ashish Bhalla
Scrub typhus, a zoonotic disease caused by the bacterium Orientia tsutsugamushi, has become endemic in many parts of India. We studied the clinical profile of this infection in 228 patients that reported to this tertiary care center from July 2013 to December 2014. The median age of patients was 35 years (interquartile range = 24.5-48.5 years), and 111 were males and 117 females. A high-grade fever occurred in 85%, breathlessness in 42%, jaundice in 32%, abdominal pain in 28%, renal failure in 11%, diarrhea in 10%, rashes in 9%, and seizures in 7%...
August 3, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27250048/clindamycin-induced-kidney-diseases-a-retrospective-analysis-of-50-patients
#4
Haiyan Wan, Zhao Hu, Jinhong Wang, Shimei Zhang, Xiangdong Yang, Tao Peng
Objective There are many adverse reactions due to clindamycin, but kidney diseases (acute kidney injury, AKI) are uncommon. However, in recent years, the rate of clindamycin-induced kidney diseases has increased. We analyzed 50 patients with clindamycin-induced kidney diseases retrospectively, and investigated the characteristics of these kidney diseases in order to provide a reference for rational clinical drug use and to reduce drug-induced organ damage. Methods We investigated 50 patients diagnosed with clindamycin-induced kidney diseases retrospectively at the Department of Nephrology, Shandong University Qilu Hospital, from January 2009 to December 2013...
2016: Internal Medicine
https://www.readbyqxmd.com/read/26969090/adjuvant-sunitinib-or-sorafenib-for-high-risk-non-metastatic-renal-cell-carcinoma-ecog-acrin-e2805-a-double-blind-placebo-controlled-randomised-phase-3-trial
#5
RANDOMIZED CONTROLLED TRIAL
Naomi B Haas, Judith Manola, Robert G Uzzo, Keith T Flaherty, Christopher G Wood, Christopher Kane, Michael Jewett, Janice P Dutcher, Michael B Atkins, Michael Pins, George Wilding, David Cella, Lynne Wagner, Surena Matin, Timothy M Kuzel, Wade J Sexton, Yu-Ning Wong, Toni K Choueiri, Roberto Pili, Igor Puzanov, Manish Kohli, Walter Stadler, Michael Carducci, Robert Coomes, Robert S DiPaola
BACKGROUND: Renal-cell carcinoma is highly vascular, and proliferates primarily through dysregulation of the vascular endothelial growth factor (VEGF) pathway. We tested sunitinib and sorafenib, two oral anti-angiogenic agents that are effective in advanced renal-cell carcinoma, in patients with resected local disease at high risk for recurrence. METHODS: In this double-blind, placebo-controlled, randomised, phase 3 trial, we enrolled patients at 226 study centres in the USA and Canada...
May 14, 2016: Lancet
https://www.readbyqxmd.com/read/26416594/allopurinol-hypersensitivity-investigating-the-cause-and-minimizing-the-risk
#6
REVIEW
Lisa K Stamp, Richard O Day, James Yun
Allopurinol is the most commonly prescribed urate-lowering therapy for the management of gout. Serious adverse reactions associated with allopurinol, while rare, are feared owing to the high mortality. Such reactions can manifest as a rash combined with eosinophilia, leukocytosis, fever, hepatitis and progressive kidney failure. Risk factors for allopurinol-related severe adverse reactions include the recent introduction of allopurinol, the presence of the HLA-B(*)58:01 allele, and factors that influence the drug concentration...
April 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/26309702/long-term-unexpected-consequence-of-two-kidney-transplants-with-full-match-grafts-a-report-of-two-cases
#7
Erhan Tatar, Adam Uslu, Ahmet Aykas, Tamer Sahin
HLA typing is the cornerstone of kidney transplantation. Here, we present two full-match kidney transplants with early uneventful course but late c4d-mediated rejection and recurrent pauce-immune necrotizing crescentic glomerulonephritis, as each in one. Case 1: A 49 years old Caucasian female patient, received a six-matched cadaveric kidney and had nonspecific changes in 6th and 12th month protocol biopsies. The first and third year serum creatinin value was 1.8 and 2.0 mg/dl. Immunosuppressive drugs were gradually reduced due to recurrent infections at the 3rd year...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25334207/an-interesting-case-of-microscopic-polyangiitis-presenting-as-rapidly-progressive-pulmonary-fibrosis
#8
Meghan Rane, Emerald Banas, Aakash Aggarwal, Michael Iannuzzi
SESSION TITLE: Miscellaneous Student/Resident CasesSESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 04:30 PM - 05:30 PMINTRODUCTION: Microscopic polyangitis (MPA) is part of a spectrum of vasculitic diseases affecting small to medium sized vessels causing rapid renal failure secondary to glomerulonephritis, non-scarring recurring rash and inflammatory changes in the lungs ranging from diffuse alveolar hemorrhage to fibrosis.CASE PRESENTATION: 63 year old Caucasian male presented with acute on chronic hypoxic respiratory failure...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/24650330/protracted-febrile-myalgia-syndrome-in-a-kidney-transplant-recipient-with-familial-mediterranean-fever
#9
Medhat M Abdel Halim, Torki Al-Otaibi, Farouk Donia, Osama Gheith, Ponnambath Asif, Moideen Nawas, Rashad H Rashad, Tarek Said, Prasad Nair, Narayanan Nampoory
Drug-induced toxic myopathy is a complication of familial Mediterranean fever in patients who receive colchicine, especially when combined with cyclosporine. Protracted febrile myalgia syndrome is a severe form of familial Mediterranean fever. A 34-year-old man who had familial Mediterranean fever for > 15 years developed kidney failure because of secondary amyloidosis. He received living-unrelated-donor kidney transplant that functioned normally. He was on colchicine prophylaxis that was continued after transplant, and he received immuno-suppression induction with antithymocyte globulin and maintenance with prednisolone, mycophenolate mofetil, and cyclosporine...
April 2015: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/24353307/mechanism-of-the-beneficial-and-protective-effects-of-exenatide-in-diabetic-rats
#10
Mohamed Lotfy, Jaipaul Singh, Hameed Rashed, Saeed Tariq, Erika Zilahi, Ernest Adeghate
Glucagon-like peptide 1 (GLP1) agonists are promising therapeutic agents in the treatment of diabetes mellitus. This study examines the mechanism of the protective effects of exenatide in experimental diabetes, employing four groups of ten rats each, in which two groups were streptozotocin-induced diabetic and two were control groups. One control and one diabetic group were treated with exenatide (1 μg/kg body weight (BW)) for 10 weeks. Blood plasma was taken for biochemical analyses while pancreatic tissue was taken for immunofluorescence and immunoelectron microscopy studies and real-time PCR to examine the expression of genes...
March 2014: Journal of Endocrinology
https://www.readbyqxmd.com/read/24296447/the-concentrations-of-bile-acids-and-erythropoietin-in-pregnant-women-with-intrahepatic-cholestasis-and-the-state-of-the-fetus-and-newborn
#11
Anna Kowalska-Kańka, Tomasz Maciejewski, Krzysztof Tomasz Niemiec
UNLABELLED: Intrahepatic cholestasis of pregnancy (ICP) is not a common complication of pregnancy, but may be a threat to fetal condition. The elevated level of bile acids defines ICP and determines its severity. Indicators of hepatocyte damage during ICP are elevated ALT and AST. The fetal condition in the ICP depends on the degree of liver damage. The most common complication is preterm delivery, but the risk of fetal death is currently around 3.5%. Erythropoietin is a peptide hormone produced mostly in the kidneys and liver due to tissue hypoxia...
July 2013: Medycyna Wieku Rozwojowego
https://www.readbyqxmd.com/read/23909652/acute-kidney-injury-in-patients-with-severe-rash-on-vemurafenib-treatment-for-metastatic-melanomas
#12
E Regnier-Rosencher, H Lazareth, L Gressier, M F Avril, E Thervet, N Dupin
Vemurafenib, a selective BRAF (v-raf murine sarcoma viral oncogene homologue B1) kinase inhibitor, is a new targeted biotherapy that improves survival in patients with metastatic melanomas harbouring the BRAF V600E mutation. However, this drug has significant dermatological adverse effects. We report a new severe cutaneous reaction to this drug associated with acute kidney injury (AKI). Four patients presented a generalized grade 3 (Common Terminology Criteria for Adverse Events) erythematous eruption with hyperkeratosis pilaris, 5-14 days after the introduction of vemurafenib...
October 2013: British Journal of Dermatology
https://www.readbyqxmd.com/read/23062091/acute-kidney-injury-a-guide-to-diagnosis-and-management
#13
Mahboob Rahman, Fariha Shad, Michael C Smith
Acute kidney injury is characterized by abrupt deterioration in kidney function, manifested by an increase in serum creatinine level with or without reduced urine output. The spectrum of injury ranges from mild to advanced, sometimes requiring renal replacement therapy. The diagnostic evaluation can be used to classify acute kidney injury as prerenal, intrinsic renal, or postrenal. The initial workup includes a patient history to identify the use of nephrotoxic medications or systemic illnesses that might cause poor renal perfusion or directly impair renal function...
October 1, 2012: American Family Physician
https://www.readbyqxmd.com/read/21993003/oxytocin-inhibits-nadph-oxidase-and-p38-mapk-in-cisplatin-induced-nephrotoxicity
#14
COMPARATIVE STUDY
Laila A Rashed, Reem M Hashem, Hala M Soliman
Oxidative stress significantly contributes to cisplatin (CP)-associated cytotoxicity, and use of antioxidants could counteract such cytotoxic effects of CP. The major biochemical pathway for reactive oxygen species (ROS) formation proceeds through O₂⁻ production, which is generated by NADPH oxidase, such oxidative stress can activate p38 MAPK to intensify the cytotoxic effect of CP. We mainly aimed to study the protective effect of oxytocin (OT) on CP-induced nephrotoxicity whereas; it was previously shown to have anti-inflammatory effects in different inflammation models...
October 2011: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/21431345/a-phase-ii-trial-of-gefitinib-and-pegylated-ifn%C3%AE-in-previously-treated-renal-cell-carcinoma
#15
Derek Shek, Jeff Longmate, David I Quinn, Kim A Margolin, Przemyslaw Twardowski, David R Gandara, Paul Frankel, Chong-Xian Pan, Primo N Lara
BACKGROUND: This study was conducted to evaluate the efficacy of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib with pegylated-IFNα (PEG-IFNα) in patients with advanced renal cell carcinoma. METHODS: Progression-free survival (PFS) rate at 6 months >50% was considered promising for further evaluation. Patients with unresectable or metastatic disease, unlimited prior therapies, and adequate performance status and end-organ function were eligible...
October 2011: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/20832553/introduction-of-mycophenolate-mofetil-in-maintenance-liver-transplant-recipients-what-can-we-expect-results-of-a-10-year-experience
#16
J Dumortier, O Guillaud, G Pittau, J Salandre, M Adham, J-Y Scoazec, O Boillot
BACKGROUND: Mycophenolate mofetil (MMF) is a cornerstone immunosuppressive drug after liver transplantation (OLT). The aim of this study was to evaluate the long term results of the addition of MMF in maintenance OLT recipients. METHODS: From 1996 to 2006, MMF was introduced because of (1) histologic features of rejection or (2) calcineurin inhibitor (CNI) toxicity in order to reduce CNI dosage. RESULTS: The study population included 208 patients (median, age 54 ± 9 years), with a median delay between OLT and MMF introduction of 54 ± 43 months...
September 2010: Transplantation Proceedings
https://www.readbyqxmd.com/read/20556772/teicoplanin-versus-vancomycin-for-proven-or-suspected-infection
#17
REVIEW
Alexandre B Cavalcanti, Anderson R Goncalves, Claudia S Almeida, Diogo Dg Bugano, Eliezer Silva
BACKGROUND: Vancomycin and teicoplanin are commonly used to treat gram-positive infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). There is uncertainty regarding the effects of teicoplanin compared to vancomycin on kidney function with some previous studies suggesting teicoplanin is less nephrotoxic than vancomycin. OBJECTIVES: To investigate the efficacy and safety of vancomycin versus teicoplanin in patients with proven or suspected infection...
2010: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/20490358/the-effect-of-chronic-candesartan-therapy-on-the-metabolic-profile-and-renal-tissue-cytokine-levels-in-the-obese-zucker-rat
#18
Carolyn M Ecelbarger, Arjun Rash, Rajesh K Sinha, Swasti Tiwari
The effect of candesartan, an angiotensin-II type-1 receptor antagonist, on the metabolic profile and renal inflammation is unclear. We evaluated this relationship by feeding male lean (LZ) and obese (OZ) Zucker rats chow or chow with candesartan (23.5 mg/kg . diet) for 14 weeks (n = 6-8/treatment/body type). Candesartan reduced serum triglycerides, plasma creatinine, urine albumin, and renal cortical collagen and glycogen deposition in the OZ. An ELISA-based cytokine array revealed that candesartan normalized elevated renal interleukin (IL) 1-beta and monocyte chemoattractant protein-1 (MCP-1) levels in OZ...
2010: Mediators of Inflammation
https://www.readbyqxmd.com/read/20016211/angiotensin-receptor-blocker-reduces-proteinuria-independently-of-blood-pressure-in-children-already-treated-with-angiotensin-converting-enzyme-inhibitors
#19
Tomás Seeman, Michael Pohl, Joachim Misselwitz, Ulrike John
BACKGROUND/AIMS: Dual blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) has higher antiproteinuric effects than single blockade in adults. In children, little is known on dual blockade of the renin-angiotensin system. The study investigates whether adding an ARB to proteinuric children already on ACEI reduces proteinuria. METHODS: A total of 10 children (median age 13.3 years) with chronic kidney disease and persistent proteinuria despite maximal dose of ACEI were included...
2009: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/18793533/severe-crescentic-bk-virus-nephropathy-with-favourable-outcome-in-a-transplanted-patient-treated-with-leflunomide
#20
G Mazzucco, C Costa, M Bergallo, G P Segoloni, G Monga
Herein reported is a severe case of BK virus nephropathy, probably caused by an intense/overimmunosuppression and identified 17 months after transplantation. The diagnostic biopsy showed extracapillary proliferation and typical cytopathic lesions, both in tubular epithelial cells and in those of the glomerular crescents. Severe inflammatory infiltrates, tubulitis, tubular atrophy and fibrosis were also observed. Immunohistochemistry and molecular biology disclosed the presence of an AS variant of the BK virus with a high viral load, both in renal tissue and urine...
August 2008: Clinical Nephrology
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