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https://www.readbyqxmd.com/read/29030687/tolerability-of-bisoprolol-on-domiciliary-spirometry-in-copd
#1
Sunny Jabbal, Brian J Lipworth
We investigated if serial domiciliary measures of spirometry were sensitive at detecting subtle effects of beta-2 blockade associated with bisoprolol in (n = 17) patients with COPD. After a two-week run in on inhaled corticosteroid (ICS) and long acting beta-2 agonist (LABA): beclometasone/formoterol 100/6 µg, patients' started additional a long acting muscarinic receptor antagonist: (LAMA) Tiotropium 18 µg, with concomitant weekly dose titration of bisoprolol: 1.25-2.5-5 mg. After a further week of bisoprolol 5 mg, they were stepped back down to (ICS/LABA) for one week...
October 14, 2017: Lung
https://www.readbyqxmd.com/read/29029185/patient-reported-outcomes-in-newly-diagnosed-early-rheumatoid-arthritis-patients-treated-to-target-with-a-tocilizumab-or-methotrexate-based-strategy
#2
Xavier M Teitsma, Johannes W G Jacobs, Paco M J Welsing, Attila Pethö-Schramm, Michelle E A Borm, Lidy Hendriks, Natasja H A M Denissen, Jacob M van Laar, Floris P J G Lafeber, Johannes W J Bijlsma
Objective: To evaluate the effect of initiation of tocilizumab, with or without MTX, compared with MTX alone on patient-reported outcomes (PROs), in DMARD-naïve patients with early RA. Methods: In U-Act-Early, patients initiated treat-to-target step-up MTX, tocilizumab or tocilizumab plus MTX therapy. PROs assessed included the Functional Assessment of Chronic Illness Therapy-Fatigue, 36-item Short Form (SF-36), five dimensional EuroQol (EQ-5D) and the Revised Illness Perception Questionnaire...
September 23, 2017: Rheumatology
https://www.readbyqxmd.com/read/28993936/the-influence-of-body-composition-on-pulmonary-rehabilitation-outcomes-in-chronic-obstructive-pulmonary-disease-patients
#3
Pichapong Tunsupon, M Jeffery Mador
INTRODUCTION: Alterations in body composition are commonly present in chronic obstructive pulmonary disease (COPD). The hypothesis of this study is that COPD patients would achieve clinical benefits after pulmonary rehabilitation (PR) independent of muscle mass depletion or body weight. METHODS: We conducted a retrospective cohort study using single-frequency bioelectrical impedance analysis (BIA) for assessment of fat-free mass (FFM) depletion (muscle depletion)...
October 9, 2017: Lung
https://www.readbyqxmd.com/read/28988878/age-variation-in-the-minimum-clinically-important-difference-in-srs-22r-after-surgical-treatment-for-adult-spinal-deformity-a-single-institution-analysis-in-japan
#4
Hideyuki Arima, Leah Y Carreon, Steven D Glassman, Yu Yamato, Tomohiko Hasegawa, Daisuke Togawa, Sho Kobayashi, Go Yoshida, Tatsuya Yasuda, Tomohiro Banno, Shin Oe, Yuki Mihara, Yukihiro Matsuyama
BACKGROUND: The Scoliosis Research Society-22r (SRS-22r) has been shown to be reliable, valid and responsive to change in patients with adult spinal deformity (ASD) undergoing surgery. The minimum clinically important difference (MCID) quantifies a threshold value of improvement that is clinically relevant to the patient. Health-related quality of life scores depend on age. The purpose of this study was to assess MCID threshold values stratified by age for SRS-22r domains in patients with ASD undergoing surgical correction...
October 5, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28986470/quality-of-life-in-inflammatory-neuropathies-the-in-qol
#5
Thomas H P Draak, Catharina G Faber, Ingemar S J Merkies
BACKGROUND: No consensus exists which quality of life (QoL) measure should be used in patients with inflammatory neuropathies. Moreover, most QoL measures are ordinal-based scales with their known deficiencies. OBJECTIVES: To establish a new disease-specific interval-based QoL questionnaire in inflammatory neuropathies (IN-QoL) using the Rasch model and evaluate its scientific properties (validity, reliability and responsiveness). METHODS: 264 patients with inflammatory neuropathies completed six commonly used QoL questionnaires...
October 6, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28973679/the-minimal-clinically-important-difference-of-the-anterior-skull-base-nasal-inventory-12
#6
Nicholas Gravbrot, Daniel F Kelly, John Milligan, Chester F Griffiths, Garni Barkhoudarian, Heidi Jahnke, William L White, Andrew S Little
BACKGROUND: The minimal clinically important difference (MCID) is defined as the smallest change in health-related quality of life (QOL) that patients consider meaningful. The MCID is essential for determining clinically significant changes, rather than simply statistically significant changes, in QOL scores. The Anterior Skull Base Nasal Inventory-12 (ASK Nasal-12), a site-specific sinonasal QOL instrument, has emerged as a standard instrument for assessing QOL in patients who have undergone endonasal transsphenoidal surgery...
August 4, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28973646/is-there-a-preoperative-morphine-equianalgesic-dose-that-predicts-ability-to-achieve-a-clinically-meaningful-improvement-following-spine-surgery
#7
Joseph B Wick, Ahilan Sivaganesan, Silky Chotai, Kristin R Archer, Samuel L Posey, Parker T Evans, Joel R Campbell, Clinton J Devin
BACKGROUND: Preoperative opioid use is widespread and associated with worse patient-reported outcomes following spine surgery. OBJECTIVE: To calculate a threshold preoperative morphine equianalgesic (MEA) dose beyond which patients are less likely to achieve the minimum clinically important difference (MCID) following elective surgery for degenerative spine disease. METHODS: The study included 543 cervical and 1293 lumbar patients. Neck Disability Index and Oswestry Disability Index scores were collected at baseline and 12 mo postoperatively...
July 25, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28973581/establishing-minimal-clinically-important-difference-of-spinal-cord-stimulation-therapy-in-post-laminectomy-syndrome
#8
Alexandra R Paul, Vignessh Kumar, Steven Roth, M Reid Gooch, Julie G Pilitsis
BACKGROUND: The concept of minimum clinically important difference (MCID) has been shown to be effective in spine surgery to differentiate between clinically insignificant and significant improvements as determined by the patient. OBJECTIVE: The MCID for spinal cord stimulation (SCS) to date has not been established. We sought to determine the MCID for SCS therapy for failed laminectomy syndromes. METHODS: Preoperative and 6-mo outcomes were assessed prospectively, including the Oswestry Disability Index (ODI), Beck Depression Inventory (BDI), and McGill and Visual Analog Survey questionnaires...
June 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28962907/effect-of-pre-injection-opioid-use-on-post-injection-patient-reported-outcomes-following-epidural-steroid-injections-for-radicular-pain
#9
Johnny J Wei, Silky Chotai, Ahilan Sivaganesan, Kristin R Archer, Byron J Schneider, Aaron J Yang, Clinton J Devin
BACKGROUND CONTEXT: Chronic opioid therapy is associated with worse patient-reported outcomes (PROs) following spine surgery. However, little literature exists on the relationship between opioid use and patient-reported outcomes following epidural steroid injections for radicular pain. PURPOSE: We evaluated the association between pre-injection opioid use and patient-reported outcomes following spine epidural steroid injection. STUDY DESIGN: This study is a retrospective analysis of a prospective longitudinal registry database...
September 26, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28956672/proxy-reported-quality-of-life-and-family-impact-for-children-followed-longitudinally-by-a-pediatric-palliative-care-team
#10
Meaghann Weaver, Christopher Wichman, Cheryl Darnall, Sue Bace, Catherine Vail, Andrew MacFadyen
BACKGROUND: One goal of pediatric palliative care is to maintain quality of life for children and their families. Quality-of-life investigations may be enhanced by considering clinically important metrics in addition to statistical significance. OBJECTIVE: The purpose of this study was to longitudinally evaluate the effect of time on quality of life and family impact for pediatric palliative care patients across all diagnoses and ages. DESIGN: This prospective quality-of-life study included administration of a 23-item PedsQL™ Measurement Model to evaluate for physical, emotional, social, and cognitive dimensions of the child's quality of life and a 36-item PedsQL Family Impact Module to assess for the familial impact at time of initial palliative care consultation, Month 6, and Month 12...
September 28, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28955499/impact-of-tocilizumab-monotherapy-on-patient-reported-outcomes-in-patients-with-rheumatoid-arthritis-from-two-randomised-controlled-trials
#11
Vibeke Strand, Margaret Michalska, Christine Birchwood, Jinglan Pei, Katie Tuckwell, Rebecca Finch, Cem Gabay, Arthur Kavanaugh, Graeme Jones
OBJECTIVE: Two randomised controlled trials, AMBITION (NCT00109408) and ADACTA (NCT01119859), showed tocilizumab (TCZ) monotherapy superior to methotrexate (MTX) and adalimumab (ADA) monotherapy, respectively, for improving rheumatoid arthritis (RA) disease activity. This study compared the benefit of TCZ versus MTX or ADA monotherapy for improving patient-reported outcomes (PROs) in patients with RA. METHODS: PROs included patient global assessment (PtGA), pain, Health Assessment Questionnaire Disability Index (HAQ-DI), Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue and Short Form-36 (SF-36) physical component summary (PCS) and mental component summary (MCS) and eight domain scores...
2017: RMD Open
https://www.readbyqxmd.com/read/28941213/adaptive-behavior-in-autism-minimal-clinically-important-differences-on-the-vineland-ii
#12
C H Chatham, K I Taylor, T Charman, X Liogier D'ardhuy, E Eule, A Fedele, A Y Hardan, E Loth, L Murtagh, M Del Valle Rubido, A San Jose Caceres, J Sevigny, L Sikich, L Snyder, J E Tillmann, P E Ventola, K L Walton-Bowen, P P Wang, T Willgoss, F Bolognani
Autism Spectrum Disorder (ASD) is associated with persistent impairments in adaptive abilities across multiple domains. These social, personal, and communicative impairments become increasingly pronounced with development, and are present regardless of IQ. The Vineland Adaptive Behavior Scales, Second Edition (Vineland-II) is the most commonly used instrument for quantifying these impairments, but minimal clinically important differences (MCIDs) on Vineland-II scores have not been rigorously established in ASD...
September 21, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28932270/repeat-treatment-with-rifaximin-improves-irritable-bowel-syndrome-related-quality-of-life-a-secondary-analysis-of-a-randomized-double-blind-placebo-controlled-trial
#13
Brooks D Cash, Mark Pimentel, Satish S C Rao, Leonard Weinstock, Lin Chang, Zeev Heimanson, Anthony Lembo
BACKGROUND: Diarrhea-predominant irritable bowel syndrome (IBS-D) impairs patient quality of life (QOL). Rifaximin is an oral, nonsystemic antibiotic indicated for IBS-D. The objective of this secondary analysis was to evaluate rifaximin retreatment on IBS-related QOL in patients with IBS-D. METHODS: Patients received open-label rifaximin 550 mg three times daily for 2 weeks. Clinical responders [simultaneously meeting weekly response criteria for abdominal pain (⩾30% improvement from baseline in mean weekly pain score) and stool consistency (⩾50% decrease from baseline in number of days/week with Bristol Stool Scale (BSS) type 6 or 7 stools) during ⩾2 of first 4 weeks posttreatment] who relapsed during an up to 18-week treatment-free observation phase were randomly assigned to receive two 2-week courses of double-blind rifaximin or placebo, separated by 10 weeks...
September 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28931621/minimal-clinically-important-difference-for-safe-and-simple-novel-acute-ischemic-stroke-therapies
#14
Jessica S Cranston, Brett D Kaplan, Jeffrey L Saver
BACKGROUND AND PURPOSE: Determining the minimal clinically important difference (MCID) is essential for evaluating novel therapies. For acute ischemic stroke, expert surveys have yielded MCIDs that are substantially higher than the MCIDs observed in actual expert behavior in guideline writing and clinical practice, potentially because of anchoring bias. METHODS: We administered a structured, internet-based survey to a cross-section of academic stroke neurologists in the United States...
September 20, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28918102/the-minimal-clinically-important-difference-for-the-rasch-neuropsychiatric-inventory-irritability-and-aggression-scale-for-traumatic-brain-injury
#15
James F Malec, Flora M Hammond
OBJECTIVE: To determine the Minimal Clinically Important Difference (MCID) for a Rasch measure derived from the Irritability/Lability and Agitation/Aggression subscales of the Neuropsychiatric Inventory (NPI-TBI-IA). DESIGN: Distribution-based statistical methods were applied to retrospective data to determine candidates for the MCID. These candidates were evaluated by anchoring the NPI-TBI-IA to Global Impression of Change (GIC) ratings by participants, significant others, and a supervising physician...
September 13, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28917395/monitoring-somatic-symptoms-in-patients-with-mental-disorders-sensitivity-to-change-and-minimal-clinically-important-difference-of-the-somatic-symptom-scale-8-sss-8
#16
Benjamin Gierk, Sebastian Kohlmann, Marion Hagemann-Goebel, Bernd Löwe, Yvonne Nestoriuc
OBJECTIVE: The SSS-8 is a brief questionnaire for the assessment of somatic symptom burden. This study examines its sensitivity to change and the minimal clinically important difference (MCID) in patients with mental disorders. METHOD: 55 outpatients with mental disorders completed the SSS-8 and measures of anxiety, depression, and disability before and after receiving treatment. Effect sizes and correlations between the change scores were calculated. The MCID was estimated using a one standard error of measurement threshold and the change in disability as an external criterion...
September 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28883090/validity-responsiveness-and-minimum-clinically-important-difference-of-the-incremental-shuttle-walk-in-idiopathic-pulmonary-fibrosis-a-prospective-study
#17
Claire M Nolan, Veronica Delogu, Matthew Maddocks, Suhani Patel, Ruth E Barker, Sarah E Jones, Samantha S C Kon, Toby M Maher, Paul Cullinan, William D-C Man
The incremental shuttle walk (ISW) is well validated in COPD but limited psychometric data restrict its use in idiopathic pulmonary fibrosis (IPF). Study 1: 50 patients performed the ISW and 6 min walk test (6MWT). Study 2: 72 patients completed the ISW before and after pulmonary rehabilitation (PR). The ISW correlated strongly with 6MWT distance (r=0.81,p<0.0001). Mean (95% confidence interval) improvement in ISW with PR was 54 (38 to 70) m with an effect size of 0.29. Distribution-based and anchor-based minimum clinically important difference (MCID) estimates ranged from 31 to 46 m...
September 7, 2017: Thorax
https://www.readbyqxmd.com/read/28882527/successful-lumbar-surgery-results-in-improved-psychological-well-being-a-longitudinal-assessment-of-depressive-and-anxiety-symptoms
#18
Carol A Mancuso, Roland Duculan, Frank P Cammisa, Andrew A Sama, Alexander P Hughes, Darren R Lebl, Federico P Girardi
BACKGROUND CONTEXT: Preoperative psychological symptoms predict surgical outcomes. The impact of surgical outcomes on psychological well-being, however, has not been delineated. PURPOSE: To compare pre- to postoperative depressive and anxiety symptoms based on success of surgery, defined as fulfilled expectations and improvement in disability and pain. STUDY DESIGN/SETTING: Prospective two-year longitudinal study in a tertiary care center PATIENT SAMPLE: 276 lumbar surgery patients OUTCOME MEASURES: the Geriatric Depression Scale (GDS) and the Spielberger State Anxiety Inventory (STAI) METHODS: Patients completed the following validated surveys several days before and again two years after surgery: the GDS with a set threshold for a positive screen for depression; the STAI with population norms used as threshold values; the Oswestry Disability Index (ODI); a numerical pain rating; and the Expectations Survey measuring amount of improvement expected...
September 4, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28879594/body-mass-index-changes-after-unicompartmental-knee-arthroplasty-do-not-adversely-influence-patient-outcomes
#19
Zhan Xia, Ming Han Lincoln Liow, Graham Seow-Hng Goh, Hwei Chi Chong, Ngai Nung Lo, Seng Jin Yeo
PURPOSE: The objective of this study is to evaluate the prevalence of patients who lost or gained weight following unicompartmental knee arthroplasty (UKA), the effect of post-operative body mass index (BMI) changes on functional outcomes and quality of life (QoL), and predictive factors associated with BMI changes. METHODS: Prospectively collected data of 1043 patients who underwent UKA between 2000 and 2014 were reviewed. BMI, Knee Society Knee Score and Function Score, Oxford Knee Score (OKS), Short-Form 36 (SF-36) Physical Component Score (PCS) and Mental Component Score and proportion of patients attaining OKS/SF-36 minimal clinically important differences (MCID) were recorded preoperatively and at 2 years post-operatively...
September 6, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28876156/home-based-circuit-training-program-for-an-adolescent-female-with-severe-traumatic-brain-injury-a-case-report
#20
Devashish Tiwari, Carol Daly, Bara Alsalaheen
Adolescents with traumatic brain injury (TBI) are often discharged from physical therapy (PT) services without transitioning into exertional conditioning programs. Active participation in physical activities with peers at school is essential to achieve a sense of accomplishment and acceptance. Factors such as reduced aerobic fitness and residual gait impairments can lead to limited participation and peer interaction. The purpose of this case report was to describe the impact of home-based circuit training (HBCT) focusing on strength and balance on gait speed (GS), energy expenditure, and functional performance in a 17-year-old female with severe TBI...
September 6, 2017: Physiotherapy Theory and Practice
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