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https://www.readbyqxmd.com/read/28433323/is-there-a-clinically-meaningful-difference-in-patient-reported-dyspnea-in-acute-heart-failure-an-analysis-from-urgent-dyspnea
#1
Peter S Pang, Kathleen A Lane, Miguel Tavares, Alan B Storrow, Changyu Shen, W Frank Peacock, Richard Nowak, Alexandre Mebazaa, Said Laribi, Judd E Hollander, Mihai Gheorghiade, Sean P Collins
BACKGROUND: Dyspnea is the most common presenting symptom in patients with acute heart failure (AHF), but is difficult to quantify as a research measure. The URGENT Dyspnea study compared 3 scales: (1) 10 cm VAS, (2) 5-point Likert, and (3) a 7-point Likert (both VAS and 5-point Likert were recorded in the upright and supine positions). However, the minimal clinically important difference (MCID) to patients has not been well established. METHODS: We performed a secondary analysis from URGENT Dyspnea, an observational, multi-center study of AHF patients enrolled within 1 h of first physician assessment in the ED...
April 19, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28431578/is-the-effectiveness-of-patellofemoral-bracing-modified-by-patellofemoral-alignment-and-trochlear-morphology
#2
Xi Zhang, Jillian P Eyles, Joanna Makovey, Matthew J Williams, David J Hunter
BACKGROUND: This study was performed to determine if the effectiveness of patellofemoral bracing as a treatment for patellofemoral osteoarthritis is influenced by patellofemoral joint alignment and trochlear morphology. We hypothesized that those with more extreme patellar malalignment would benefit more from bracing. METHODS: Thirty-eight patients who had received bracing as part of a comprehensive treatment plan for patellofemoral osteoarthritis were selected for this study...
April 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28394084/personalised-asthma-action-plans-for-adults-with-asthma
#3
REVIEW
Timothy L Gatheral, Alison Rushton, David Jw Evans, Caroline A Mulvaney, Nathan R Halcovitch, Gemma Whiteley, Fiona Jr Eccles, Sally Spencer
BACKGROUND: A key aim of asthma care is to empower each person to take control of his or her own condition. A personalised asthma action plan (PAAP), also known as a written action plan, an individualised action plan, or a self-management action plan, contributes to this endeavour. A PAAP includes individualised self-management instructions devised collaboratively with the patient to help maintain asthma control and regain control in the event of an exacerbation. A PAAP includes baseline characteristics (such as lung function), maintenance medication and instructions on how to respond to increasing symptoms and when to seek medical help...
April 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28376120/acupuncture-for-benign-prostatic-hyperplasia-a-systematic-review-and-meta-analysis
#4
Wei Zhang, Liyan Ma, Brent A Bauer, Zhishun Liu, Yao Lu
PURPOSE: This systematic review and meta-analysis aims to assess the therapeutic and adverse effects of acupuncture for benign prostatic hyperplasia (BPH) in randomized controlled trials (RCTs). METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, the Chinese Biomedical Database, the China National Knowledge Infrastructure, the VIP Database and the Wanfang Database. Parallel-group RCTs of acupuncture for men with symptomatic BPH were included...
2017: PloS One
https://www.readbyqxmd.com/read/28371025/treatment-response-to-sildenafil-in-men-with-erectile-dysfunction-relative-to-concomitant-comorbidities-and-age
#5
Irwin Goldstein, Vera Stecher, Martin Carlsson
AIM: To evaluate treatment response in men with erectile dysfunction (ED) and concomitant comorbidities. METHODS: Data were pooled from 42 placebo-controlled, flexible-dose sildenafil trials. In most trials, the sildenafil dose was 50 mg, taken ~1 hour before sexual activity but not more than once daily, with adjustment to 100 or 25 mg as needed. The overall population (N=9413) was stratified by age (<45, 46-64, ≥65 years). Treatment response was defined as a minimal clinically important difference (MCID) from baseline in the International Index of Erectile Function-Erectile Function (IIEF-EF) domain score of >2, >5 and >7 for men with mild, moderate and severe ED at baseline, respectively, or an IIEF-EF domain score ≥26 (no ED) at end-point...
March 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28366584/control-of-allergic-rhinitis-and-asthma-test-for-children-caratkids-validation-in-brazil-and-cutoff-values
#6
Rita Amaral, Ana C Carneiro, Gustavo Wandalsen, João A Fonseca, Dirceu Sole
BACKGROUND: The Control of Allergic Rhinitis and Asthma Test for Children (CARATKids) assesses asthma and allergic rhinitis control in children younger than 12 years. OBJECTIVE: To validate the Brazilian Portuguese version of the CARATKids and to define the cutoff values for identifying uncontrolled disease. METHODS: Children aged 6 to 12 years with asthma and allergic rhinitis were studied (n = 102). CARATKids, childhood Asthma Control Test (cACT), total nasal symptom score (TNSS), and visual analog scale (VAS) scores were obtained at baseline and after 4 to 6 weeks...
March 30, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28361468/impact-of-participation-in-the-adalimumab-humira-patient-support-program-on-rheumatoid-arthritis-treatment-course-results-from-the-passion-study
#7
Filip Van den Bosch, Andrew J K Ostor, Siegfried Wassenberg, Naijun Chen, Chen Wang, Vishvas Garg, Jasmina Kalabic
INTRODUCTION: Patients with rheumatoid arthritis (RA) who are treated with adalimumab (ADA) are offered a proprietary patient support program (PSP, AbbVie Care(®)). The main objective of this study was to examine the effectiveness of ADA on RA treatment course over time in the context of PSP utilization. METHODS: PASSION was a 78-week post-marketing observational study of RA patients with an insufficient response to ≥1 DMARD newly initiating ADA in routine clinical care that was conducted in Europe, Israel, Mexico, Puerto Rico, and Australia...
March 30, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/28357679/changes-in-quality-of-life-after-elective-surgery-an-observational-study-comparing-two-measures
#8
Vanessa L Kronzer, Michelle R Jerry, Arbi Ben Abdallah, Troy S Wildes, Sherry L McKinnon, Anshuman Sharma, Michael S Avidan
PURPOSE: Our main objective was to compare the change in a validated quality of life measure to a global assessment measure. The secondary objectives were to estimate the minimum clinically important difference (MCID) and to describe the change in quality of life by surgical specialty. METHODS: This prospective cohort study included 7902 adult patients undergoing elective surgery. Changes in the Veterans RAND 12-Item Health Survey (VR-12), composed of a physical component summary (PCS) and a mental component summary (MCS), were calculated using preoperative and postoperative questionnaires...
March 29, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28353050/do-surgeon-expectations-predict-clinically-important-improvements-in-womac-scores-after-tha-and-tka
#9
Hassan M K Ghomrawi, Carol A Mancuso, Allison Dunning, Alejandro Gonzalez Della Valle, Michael Alexiades, Charles Cornell, Thomas Sculco, Matthias Bostrom, David Mayman, Robert G Marx, Geoffrey Westrich, Michael O'Dell, Alvin I Mushlin
BACKGROUND: Failure of THA or TKA to meet a patient's expectations may result in patient disappointment and litigation. However, there is little evidence to suggest that surgeons can consistently anticipate which patients will benefit from those interventions. QUESTIONS/PURPOSES: To determine the ability of surgeons to identify, in advance of surgery, patients who will benefit from THA or TKA and those who will not, where 'benefit' is defined as a clinically important improvement in a validated patient-reported outcomes score...
March 28, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28349563/defining-surgical-criteria-for-empty-nose-syndrome-validation-of-the-office-based-cotton-test-and-clinical-interpretability-of-the-validated-empty-nose-syndrome-6-item-questionnaire
#10
Andrew Thamboo, Nathalia Velasquez, Al-Rahim R Habib, David Zarabanda, Hassan Paknezhad, Jayakar V Nayak
OBJECTIVES/HYPOTHESIS: The validated Empty Nose Syndrome 6-Item Questionnaire (ENS6Q) identifies empty nose syndrome (ENS) patients. The unvalidated cotton test assesses improvement in ENS-related symptoms. By first validating the cotton test using the ENS6Q, we define the minimal clinically important difference (MCID) score for the ENS6Q. STUDY DESIGN: Individual case-control study. METHODS: Fifteen patients diagnosed with ENS and 18 controls with non-ENS sinonasal conditions underwent office cotton placement...
March 27, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28331638/effect-on-gait-speed-balance-motor-symptom-rating-and-quality-of-life-in-those-with-stage-i-parkinson-s-disease-utilizing-lsvt-big%C3%A2
#11
Beth Millage, Erin Vesey, Marsha Finkelstein, Mattie Anheluk
Individuals with Parkinson's Disease (PD) are often not referred to Physical Therapy (PT) until there are issues with mobility in later Hoehn and Yahr Stages. There have been no studies outlining the benefits of PT intervention in Stage I only. For persons with PD, deficits in motor function increase over time due to destruction of dopamine-producing cells. LSVT BIG, an exercise program for PD, has been shown to be effective in improving mobility. The purpose of this study was to assess participants functional improvement at a level of minimal clinically important difference (MCID) in one of four outcome measures: Gait Speed, Berg Balance Assessment, Functional Gait Assessment, and Unified Parkinson's Disease Rating Scale Motor Section...
2017: Rehabilitation Research and Practice
https://www.readbyqxmd.com/read/28326189/sarilumab-improves-patient-reported-outcomes-in-rheumatoid-arthritis-patients-with-inadequate-response-intolerance-to-tumour-necrosis-factor-inhibitors
#12
Vibeke Strand, Matthew Reaney, Chieh-I Chen, Clare W J Proudfoot, Sophie Guillonneau, Deborah Bauer, Erin Mangan, Neil M H Graham, Hubert van Hoogstraten, Yong Lin, César Pacheco-Tena, Roy Fleischmann
OBJECTIVE: To evaluate effects of the anti-interleukin-6 receptor monoclonal antibody sarilumab administered with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) on patient-reported outcomes (PROs) in the TARGET trial in patients with rheumatoid arthritis (RA) with inadequate response or intolerance to tumour necrosis factor inhibitors (TNF-IR). METHODS: 546 patients (81.9% female, mean age 52.9 years) were randomised to placebo, sarilumab 150 or 200 mg subcutaneously every 2 weeks + csDMARDs...
2017: RMD Open
https://www.readbyqxmd.com/read/28320078/comparison-of-the-sensitivity-to-change-of-the-36-item-short-form-health-survey-and-the-lupusqol-using-various-definitions-of-minimal-clinically-important-differences-in-patients-with-active-systemic-lupus-erythematosus
#13
Stephanie G Nantes, Vibeke Strand, Jiandong Su, Zahi Touma
OBJECTIVES: Medical Outcomes Study Short-Form 36 (SF-36) and LupusQoL are Health-Related Quality-of-Life (HRQoL) questionnaires used in systemic lupus erythematosus (SLE). We determined the hypothesis testing construct validity of SF-36 and LupusQoL against disease activity in patients with active SLE and 2) compared the sensitivity to change of SF-36 and LupusQoL domains according to different definitions of Minimal Clinically Important Differences (MCID) for improvement and worsening in the current cohort...
March 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28318816/use-of-electromyography-to-optimize-lokomat-%C3%A2-settings-for-subject-specific-gait-rehabilitation-in-post-stroke-hemiparetic-patients-a-proof-of-concept-study
#14
Yosra Cherni, Mickael Begon, Hicham Chababe, Florent Moissenet
OBJECTIVES: While generic protocols exist for gait rehabilitation using robotic orthotics such as the Lokomat(®), several settings - guidance, body-weight support (BWS) and velocity - may be adjusted to individualize patient training. However, no systematic approach has yet emerged. Our objective was to assess the feasibility and effects of a systematic approach based on electromyography to determine subject-specific settings with application to the strengthening of the gluteus maximus muscle in post-stroke hemiparetic patients...
March 16, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28298057/defining-the-substantial-clinical-benefit-after-arthroscopic-treatment-of-femoroacetabular-impingement
#15
Benedict U Nwachukwu, Brenda Chang, Kara Fields, Brian J Rebolledo, Danyal H Nawabi, Bryan T Kelly, Anil S Ranawat
BACKGROUND: The minimal clinically important difference (MCID) has been defined in orthopaedics and is the smallest change that a patient considers meaningful. Less is known about improvements that the patient perceives as clinically considerable, or the substantial clinical benefit (SCB). For the young, highly functioning patient cohort with femoroacetabular impingement (FAI), the SCB is an important measure of clinical success. PURPOSE: To derive the SCB for FAI treatment and identify outcome score thresholds and patient variables predictive of the SCB...
February 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28294430/rapid-improvements-in-health-related-quality-of-life-and-itch-with-ixekizumab-treatment-in-randomized-phase-3-trials-results-from-uncover-2-and-uncover-3
#16
C L Leonardi, A Blauvelt, H L Sofen, M Gooderham, M Augustin, R Burge, B Zhu, K Reich
BACKGROUND: Patients with moderate-to-severe psoriasis report impaired health-related quality of life (HRQoL). OBJECTIVE: To assess speed of onset of ixekizumab-induced clinically relevant improvement in HRQoL. METHODS: This post-hoc analysis used pooled data from patients randomized in UNCOVER-2 and UNCOVER-3, and treated with 80 mg ixekizumab every 2 weeks (IXEQ2W), 80 mg ixekizumab every 4 weeks (IXEQ4W), 50 mg etanercept (ETN) twice weekly, or placebo (PBO) for 12 weeks...
March 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28289561/comparison-of-hand-grip-strength-and-upper-limb-pressure-pain-threshold-between-older-adults-with-or-without-non-specific-shoulder-pain
#17
Cesar Calvo Lobo, Carlos Romero Morales, David Rodríguez Sanz, Irene Sanz Corbalán, Eleuterio A Sánchez Romero, Josué Fernández Carnero, Daniel López López
BACKGROUND: There is a high prevalence of non-specific shoulder pain associated with upper limb functional limitations in older adults. The purpose of this study was to determine the minimal clinically important differences (MCID) of grip strength and pressure pain threshold (PPT) in the upper limb between older adults with or without non-specific shoulder pain. METHODS: A case-control study was carried out following the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria...
2017: PeerJ
https://www.readbyqxmd.com/read/28276990/how-are-we-measuring-clinically-important-outcome-for-operative-treatments-in-sports-medicine
#18
Benedict U Nwachukwu, R Scott Runyon, Cynthia A Kahlenberg, Elizabeth B Gausden, William W Schairer, Answorth A Allen
OBJECTIVES: Minimal clinically important difference (MCID) and other measures of minimum clinical importance are increasingly recognized as important clinical considerations for evaluating the efficacy of an intervention. As our interpretation of clinical outcome evolves beyond statistical significance, psychometric properties such as MCID will be increasingly important to various stakeholders in the orthopaedic community. The purpose of this study was to: 1) describe the state of clinically important outcome reporting and 2) describe the methods used to derive these psychometric values for sports medicine patients undergoing operative treatments...
May 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28257619/complaints-of-upper-extremity-numbness-and-tingling-relieved-with-dry-needling-of-the-teres-minor-and-infraspinatus-a-case-report
#19
Elizabeth Lane, Derek Clewley, Shane Koppenhaver
Study Design Case report. Background Abnormal sensation, such as numbness or tingling, is traditionally thought to originate from neural compression. There is limited evidence to support reports of abnormal sensation arising from a trigger point. Case Description The patient was a 60-year-old female with primary complaints of right shoulder pain and secondary complaints of neck pain and right upper extremity numbness. Cervical spine neurological examination was unremarkable, and manual examination did not reproduce the patient's arm numbness or tingling symptoms...
March 3, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28254639/psychometric-and-clinimetric-properties-of-the-melbourne-assessment-2-in-children-with-cerebral-palsy
#20
Tien-Ni Wang, Kai-Jie Liang, Yi-Chia Liu, Jeng-Yi Shieh, Hao-Ling Chen
OBJECTIVE: The Melbourne Assessment 2 (MA2) is increasingly used as an outcome measurement in clinical studies. The purposes of this study were to examine its psychometric and clinimetric properties. DESIGN: Psychometric and clinimetric study. SETTING: Community. PARTICIPANTS: Seventeen children with CP from 5 to 12 years were recruited for the estimation of the test-retest reliability and minimal detectable change (MDC)...
February 27, 2017: Archives of Physical Medicine and Rehabilitation
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