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https://www.readbyqxmd.com/read/29244235/new-therapy-for-refractory-chronic-mechanical-low-back-pain-restorative-neurostimulation-to-activate-the-lumbar-multifidus-one-year-results-of-a-prospective-multicenter-clinical-trial
#1
REVIEW
Kristiaan Deckers, Kris De Smedt, Bruce Mitchell, David Vivian, Marc Russo, Peter Georgius, Matthew Green, John Vieceli, Sam Eldabe, Ashish Gulve, Jean-Pierre van Buyten, Iris Smet, Vivek Mehta, Shankar Ramaswamy, Ganesan Baranidharan, Richard Sullivan, Robert Gassin, James Rathmell, Chris Gilligan
OBJECTIVES: The purpose of the international multicenter prospective single arm clinical trial was to evaluate restorative neurostimulation eliciting episodic contraction of the lumbar multifidus for treatment of chronic mechanical low back pain (CMLBP) in patients who have failed conventional therapy and are not candidates for surgery or spinal cord stimulation (SCS). MATERIALS AND METHODS: Fifty-three subjects were implanted with a neurostimulator (ReActiv8, Mainstay Medical Limited, Dublin, Ireland)...
December 15, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29243999/efficacy-of-intraoperative-epidural-triamcinolone-application-in-lumbar-microdiscectomy-a-matched-control-study
#2
Martin N Stienen, Holger Joswig, Ivan Chau, Marian C Neidert, David Bellut, Thomas Wälchli, Karl Schaller, Oliver P Gautschi
OBJECTIVE The purpose of this study was to investigate whether the intraoperative application of an epidural steroid (ES) on the decompressed nerve root improves short- and midterm subjective and objective clinical outcomes after lumbar microdiscectomy. METHODS This study was a retrospective analysis of a 2-center database including consecutive cases in which patients underwent lumbar microdiscectomy. All patients who received ES application (40 mg triamcinolone, ES group) were matched by age and sex to patients who had not received ES application (control group)...
December 15, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29243996/validation-of-the-visual-analog-scale-in-the-cervical-spine
#3
Anna MacDowall, Martin Skeppholm, Yohan Robinson, Claes Olerud
OBJECTIVE The visual analog scale (VAS) is frequently used to measure treatment outcome in patients with cervical spine disorders. The minimum clinically important difference (MCID) is the smallest change in a score that has clinical importance to the patient. Although it has been established for other medical fields, knowledge of the VAS MCID for the cervical spine is sparse, and it has rarely been considered in relation to measurement noise. The goals in this study were as follows: 1) to validate the VAS-neck and VAS-arm instruments for the cervical spine (e...
December 15, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29231073/pelargonium-sidoides-preparation-eps-7630-in-copd-health-related-quality-of-life-and-other-patient-reported-outcomes-in-adults-receiving-add-on-therapy
#4
Heinrich Matthys, Petra Funk
OBJECTIVE: Patient-reported outcomes (PRO) such as health-related quality of life (HRQL) belong to the most important criteria for the evaluation of medical therapies in clinical trials or practice-based benefit assessments. We therefore revisited results of an earlier published clinical trial investigating the effects of the herbal drug preparation from the roots of Pelargonium sidoides EPs 7630, administered as add-on therapy in patients suffering from chronic obstructive pulmonary disease (COPD), with respect to HRQL and other PRO...
December 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29219184/minimal-clinically-important-difference-of-voice-handicap-index-10-in-vocal-fold-paralysis
#5
VyVy N Young, Kwonho Jeong, Scott D Rothenberger, Amanda I Gillespie, Libby J Smith, Jackie L Gartner-Schmidt, Clark A Rosen
OBJECTIVES/HYPOTHESIS: The Voice Handicap Index-10 (VHI-10) is commonly used to measure patients' perception of vocal handicap. Clinical consensus has previously defined clinically meaningful improvement as a decrease ≥5. This study determines the minimal clinically important difference (MCID) for VHI-10 in patients with unilateral vocal fold paralysis (UVFP) using anchor-based methodology. STUDY DESIGN: Prospective cohort questionnaire analysis. METHODS: Two hundred eighty-one UVFP patients completed the VHI-10 on two consecutive visits (within 3 months)...
December 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29215503/minimum-detectable-measurement-difference-mdmd-for-health-related-quality-of-life-hrql-measures-varies-according-age-and-disability-in-adult-spinal-deformity-asd-implications-for-calculating-minimal-clinically-important-difference-mcid
#6
Michael P Kelly, Han Jo Kim, Christopher P Ames, Douglas C Burton, Leah Yacat Carreon, David W Polly, Richard Hostin, Amit Jain, Jeffrey L Gum, Virginie Lafage, Frank J Schwab, Christopher I Shaffrey, Justin S Smith, Shay Bess
STUDY DESIGN: Retrospective cohort. OBJECTIVE: To investigate the minimum detectable measurement difference (MDMD) in the Scoliosis Research Society-22r (SRS-22r) outcomes instrument in adult spinal deformity (ASD) and to evaluate the effect of baseline data on measurable difference. SUMMARY OF BACKGROUND DATA: The minimum clinically important difference (MCID) is the smallest, clinically relevant change observed and has been proposed for the SRS-22r instrument in ASD as 0...
December 5, 2017: Spine
https://www.readbyqxmd.com/read/29212251/low-ft3-is-associated-with-diminished-health-related-quality-of-life-in-patients-with-acute-coronary-syndrome-treated-with-drug-eluting-stent-a-longitudinal-observational-study
#7
Chao Xue, Ling Bian, Yu Shui Xie, Zhao Fang Yin, Zuo Jun Xu, Qi Zhi Chen, Hui Li Zhang, Yu Qi Fan, Run Du, Chang Qian Wang
Acute coronary syndrome (ACS) patients with low triiodothyronine (T3) syndrome characterized by low free T3 (fT3) levels with normal thyroxine (T4) and thyroid-stimulating hormone (TSH) have a higher rate of death. The impact of fT3 on Health related quality of life (HRQOL) in patients with ACS is still unknown. 528 ACS patients treated with drug-eluting stent (DES) were included in this prospective, observational study. Patients were classified into low fT3 group (n=126) and normal fT3 group (n=402) according to serum fT3 level...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29203380/periarticular-injection-versus-femoral-nerve-block-for-pain-relief-after-anterior-cruciate-ligament-reconstruction-a-randomized-controlled-trial
#8
Kenji Kurosaka, Sachiyuki Tsukada, Hiroshi Nakayama, Tomoya Iseki, Ryo Kanto, Ryo Sugama, Shinichi Yoshiya
PURPOSE: To compare the effectiveness and safety of periarticular injection (PI) with those of femoral nerve block (FNB) after anterior cruciate ligament (ACL) reconstruction. METHODS: A total of 129 patients scheduled for ACL reconstruction were randomly assigned to receive PI or FNB. Other perioperative interventions were identical for all patients. The primary outcome was the postoperative pain score 24 hours after surgery, which was measured using a 100-mm visual analog scale (VAS)...
December 1, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29201296/predictors-of-midterm-outcomes-after-medial-unicompartmental-knee-arthroplasty-in-asians
#9
Hamid Rahmatullah Bin Abd Razak, Sanchalika Acharyya, Shi-Ming Tan, Hee-Nee Pang, Keng-Jin Darren Tay, Shi-Lu Chia, Ngai-Nung Lo, Seng-Jin Yeo
Background: This study was designed to evaluate predictors of good outcomes following medial unicompartmental knee arthroplasty (UKA) in Asian patients. Methods: Registry data of patients who underwent primary unilateral medial UKA from 2006 to 2011 were collected. Outcomes studied were the Oxford Knee Score (OKS) and the Physical Component Score (PCS) of the Short Form 36 (SF-36) questionnaire. These outcome scores were collected prospectively, pre- and postoperatively up to 5 years...
December 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/29191094/potential-of-predictive-computer-models-for-preoperative-patient-selection-to-enhance-overall-quality-adjusted-life-years-gained-at-2-year-follow-up-a-simulation-in-234-patients-with-adult-spinal-deformity
#10
Taemin Oh, Justin K Scheer, Justin S Smith, Richard Hostin, Chessie Robinson, Jeffrey L Gum, Frank Schwab, Robert A Hart, Virginie Lafage, Douglas C Burton, Shay Bess, Themistocles Protopsaltis, Eric O Klineberg, Christopher I Shaffrey, Christopher P Ames
OBJECTIVE Patients with adult spinal deformity (ASD) experience significant quality of life improvements after surgery. Treatment, however, is expensive and complication rates are high. Predictive analytics has the potential to use many variables to make accurate predictions in large data sets. A validated minimum clinically important difference (MCID) model has the potential to assist in patient selection, thereby improving outcomes and, potentially, cost-effectiveness. METHODS The present study was a retrospective analysis of a multiinstitutional database of patients with ASD...
December 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29188483/minimal-clinically-important-differences-in-the-eortc-qlq-c30-and-brief-pain-inventory-in-patients-undergoing-re-irradiation-for-painful-bone-metastases
#11
Srinivas Raman, Keyue Ding, Edward Chow, Ralph M Meyer, Yvette M van der Linden, Daniel Roos, William F Hartsell, Peter Hoskin, Jackson S Y Wu, Abdenour Nabid, Rick Haas, Ruud Wiggenraad, Scott Babington, William F Demas, Carolyn F Wilson, Rebecca K S Wong, Liting Zhu, Michael Brundage
PURPOSE: The EORTC QLQ-C30 and the Brief Pain Inventory (BPI) are validated tools for measuring quality of life (QOL) and the impact of pain in patients with advanced cancer. Interpretation of these instrument scores can be challenging and it is difficult to know what numerical changes translate to clinically significant impact in patients' lives. To address this issue, our study sought to establish the minimal clinically important differences (MCID) for these two instruments in a prospective cohort of patients with advanced cancer and painful bone metastases...
November 29, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29186177/intensive-care-syndrome-promoting-independence-and-return-to-employment-ins-pire-early-evaluation-of-a-complex-intervention
#12
Joanne McPeake, Martin Shaw, Theodore J Iwashyna, Malcolm Daniel, Helen Devine, Lyndsey Jarvie, John Kinsella, Pamela MacTavish, Tara Quasim
BACKGROUND: Many patients suffer significant physical, social and psychological problems in the months and years following critical care discharge. At present, there is minimal evidence of any effective interventions to support this patient group following hospital discharge. The aim of this project was to understand the impact of a complex intervention for ICU survivors. METHODS: Quality improvement project conducted between September 2014 and June 2016, enrolling 49 selected patients from one ICU in Scotland...
2017: PloS One
https://www.readbyqxmd.com/read/29177632/the-use-of-lumbar-epidural-injection-of-platelet-lysate-for-treatment-of-radicular-pain
#13
Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Matthew Hyzy, Christopher Williams, Michael Freeman
BACKGROUND: Epidural steroid injections (ESI) are the most common pain management procedure performed in the US, however evidence of efficacy is limited. In addition, there is early evidence that the high dose of corticosteroids used can have systemic side effects. We describe the results of a case series evaluating the use of platelet lysate (PL) epidural injections for the treatment of lumbar radicular pain as an alternative to corticosteroids. METHODS: Registry data was obtained for patients (N = 470) treated with PL epidural injections presenting with symptoms of lumbar radicular pain and MRI findings that were consistent with symptoms...
November 25, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29171797/health-related-quality-of-life-outcomes-in-complex-adult-spinal-deformity-surgery
#14
Max S Riley, Keith H Bridwell, Lawrence G Lenke, Jonathan Dalton, Michael P Kelly
OBJECTIVE Significant health-related quality of life (HRQOL) benefits have been observed for patients undergoing primary and revision adult spinal deformity (ASD) surgery. The purpose of this study was to report changes in HRQOL measures in a consecutive series of patients undergoing complex spinal reconstructive surgery, using Scoli-RISK-1 (SR-1) inclusion criteria. METHODS This was a single-center, retrospective cohort study. The SR-1 inclusion criteria were used to define patients with complex ASD treated between June 1, 2009, and June 1, 2011...
November 24, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29167064/the-effect-of-adjuvant-chemotherapy-on-symptom-burden-and-quality-of-life-over-time-a-preliminary-prospective-observational-study-using-individual-data-of-patients-aged-%C3%A2-70-with-early-stage-invasive-breast-cancer
#15
Chantal Quinten, C Kenis, M Hamaker, A Coolbrandt, B Brouwers, L Dal Lago, P Neven, P Vuylsteke, G Debrock, H Van Den Bulck, A Smeets, P Schöffski, A Bottomley, U Wedding, H Wildiers
OBJECTIVES: We aim to assess short and long term effects of chemotherapy on patient-reported quality of life (QOL) and patient versus clinician symptom reporting in older patients with breast cancer adjusted for tumour and aging parameters. MATERIAL AND METHODS: In this prospective, multicentre, non-interventional, observational study, women aged ≥70years were enrolled after surgery and assigned to a TC chemotherapy (docetaxel and cyclophosphamide) group or a control group depending on their planned adjuvant treatment...
November 19, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29162305/quantifying-success-after-total-shoulder-arthroplasty-the-minimal-clinically-important-difference
#16
Ryan Simovitch, Pierre-Henri Flurin, Thomas Wright, Joseph D Zuckerman, Christopher P Roche
BACKGROUND: Knowledge of the minimal clinically important difference (MCID) for different shoulder outcome metrics and range of motion after total shoulder arthroplasty (TSA) can be useful to establish a minimum threshold of improvement that defines successful treatment. This study quantifies how MCID varies with different prosthesis types, patient age, gender, and length of follow-up after TSA. METHODS: A total of 466 anatomic TSA (aTSA) and reverse TSA (rTSA) with 2-year minimum follow-up were performed by 13 shoulder surgeons...
November 18, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29161115/hip-arthroscopic-surgery-for-femoroacetabular-impingement-with-capsular-management-factors-associated-with-achieving-clinically-significant-outcomes
#17
Gregory L Cvetanovich, Alexander E Weber, Benjamin D Kuhns, Jennifer Alter, Joshua D Harris, Richard C Mather, Shane J Nho
BACKGROUND: There has been increasing interest in defining clinically meaningful outcomes in patient reported outcomes following orthopaedic surgery. Little is known about the factors associated with clinically meaningful outcomes after hip arthroscopy for femoroacetabular impingement. STUDY DESIGN: Case-control study; Level of evidence, 3. PURPOSE: To report on a large, prospectively collected consecutive series of patients who underwent comprehensive arthroscopic treatment of femoroacetabular impingement (FAI) and capsular management with greater than 2-year follow-up...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29141079/visual-function-response-to-ocriplasmin-for-the-treatment-of-vitreomacular-traction-and-macular-hole-the-oasis-study
#18
RANDOMIZED CONTROLLED TRIAL
Benedicte Lescrauwaet, Luc Duchateau, Thomas Verstraeten, Timothy L Jackson
Purpose: To assess the effect of ocriplasmin on visual function response (VFR) measured using visual acuity (VA) and vision-related quality of life, and to quantify the association between release of vitreomacular adhesion (VMA) at day 28 and VFR. Methods: Prespecified analysis of secondary endpoints from a randomized controlled trial. Of 220 participants with symptomatic VMA/vitreomacular traction (VMT), including VMT associated with a macular hole up to 400 μm, 146 received a single intravitreal injection of 125 μg ocriplasmin and 74 a sham injection...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29128966/is-the-dlqi-appropriate-for-medical-decision-making-in-psoriasis-patients
#19
Adrienn Katalin Poór, Valentin Brodszky, Márta Péntek, László Gulácsi, Gábor Ruzsa, Bernadett Hidvégi, Péter Holló, Sarolta Kárpáti, Miklós Sárdy, Fanni Rencz
Dermatology Life Quality Index (DLQI) is the most commonly applied measure of health-related quality of life (HRQoL) in psoriasis patients. It is among defining criteria of moderate-to-severe psoriasis and present in treatment guidelines. Our objective was to estimate preference-based HRQoL values (i.e., utilities) for hypothetical health states described by the 10 items of the DLQI in psoriasis patients. Moreover, we compare results to findings of a similar study previously conducted among the general public...
November 11, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29108487/a-clinically-meaningful-training-effect-in-walking-speed-using-functional-electrical-stimulation-for-motor-incomplete-spinal-cord-injury
#20
Tamsyn Street, Christine Singleton
CONTEXT/OBJECTIVE: The study aimed to investigate the presence of a training effect for rehabilitation of walking function in motor-incomplete spinal cord injury (SCI) through daily use of functional electrical stimulation (FES). SETTING: A specialist FES outpatient centre Participants: Thirty-five participants (mean age 53, SD 15, range 18-80; mean years since diagnosis 9, range 5 months - 39 years) with drop foot and motor-incomplete SCI (T12 or higher, ASIA Impairment Scale C and D) able to ambulate 10 metres with the use of a walking stick or frame...
November 6, 2017: Journal of Spinal Cord Medicine
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