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https://www.readbyqxmd.com/read/27931954/younger-patients-have-less-severe-radiographic-disease-and-lower-reported-outcome-scores-than-older-patients-undergoing-total-knee-arthroplasty
#1
Jacob Haynes, Adam Sassoon, Denis Nam, Loren Schultz, James Keeney
BACKGROUND: Total knee arthroplasty (TKA) has been successful for many younger patients, but some experience residual symptoms or dissatisfaction. We performed this study to assess the relationship between radiographic disease severity and patient demographic features on patient reported TKA outcome scores. METHODS: We compared 100 TKAs performed for 82 patients ≤55years old with 100 gender-matched TKAs performed for 85 patients between 65 and 75years old. These study cases represented 25% and 21%, respectively, of TKAs performed between January 2006 and June 2011...
December 5, 2016: Knee
https://www.readbyqxmd.com/read/27931242/achieving-good-outcomes-for-asthma-living-goal-mixed-methods-feasibility-and-pilot-cluster-randomised-controlled-trial-of-a-practical-intervention-for-eliciting-setting-and-achieving-goals-for-adults-with-asthma
#2
Gaylor Hoskins, Brian Williams, Purva Abhyankar, Peter Donnan, Edward Duncan, Hilary Pinnock, Marjon van der Pol, Petra Rauchhaus, Anne Taylor, Aziz Sheikh
BACKGROUND: Despite being a core component of self-management, goal setting is rarely used in routine care. We piloted a primary care, nurse-led intervention called Achieving Good Outcomes for Asthma Living (GOAL) for adults with asthma. Patients were invited to identify and prioritise their goals in preparation for discussing and negotiating an action/coping plan with the nurse at a routine asthma review. METHODS: The 18-month mixed methods feasibility cluster pilot trial stratified and then randomised practices to deliver usual care (UC) or a goal-setting intervention (GOAL)...
December 8, 2016: Trials
https://www.readbyqxmd.com/read/27927495/the-substantial-clinical-benefit-threshold-for-srs-22r-domains-after-surgical-treatment-of-adult-spinal-deformity
#3
Charles H Crawford, Steven D Glassman, Keith H Bridwell, Leah Y Carreon
STUDY DESIGN: Longitudinal cohort. OBJECTIVES: To determine Substantial Clinical Benefit (SCB) thresholds for the SRS22R domains in patients undergoing adult spinal deformity surgery. SUMMARY OF BACKGROUND DATA: The Scoliosis Research Society 22R (SRS22R) has been shown to be reliable, valid, and responsive to change in adult spinal deformity patients. Although the minimal clinically important difference (MCID) is commonly used to quantify a threshold of improvement, it could be considered a floor value rather than a goal...
September 2016: Spine Deformity
https://www.readbyqxmd.com/read/27922579/srs-22r-scores-in-non-operated-adolescent-idiopathic-scoliosis-patients-with-curves-greater-than-forty-degrees
#4
W Timothy Ward, Nicole A Friel, Tanya S Kenkre, Maria M Brooks, Joanne A Londino, James W Roach
STUDY DESIGN: Case control comparative series OBJECTIVE.: Describe surgical range adolescent idiopathic scoliosis (AIS) patients electing to forgo surgery and compare health related quality of life outcomes to a similar cohort of operated AIS patients by the same single surgeon. SUMMARY OF BACKGROUND DATA: No data have been published either documenting SRS-22r scores of non-operated patients with curves ≥ 40° or comparing these scores to a demographically similar operated cohort...
December 2, 2016: Spine
https://www.readbyqxmd.com/read/27919315/implication-of-alternative-minimal-clinically-important-difference-threshold-estimation-methods-on-technology-assessment
#5
Diana Brixner, Eli O Meltzer, Kellie Morland, Cathryn A Carroll, Ullrich Munzel, Brian J Lipworth
OBJECTIVES: Various minimal clinically important difference (MCID) threshold estimation techniques have been applied to seasonal allergic rhinitis (SAR). The objectives of this study are to (i) assess the difference in magnitude of alternative SAR MCID threshold estimates and (ii) evaluate the impact of alternative MCID estimates on health technology assessment (HTA). METHODS: Data describing change from baseline of the reflective Total Nasal Symptom Score (rTNSS) for four intranasal SAR treatments were obtained from United States Food and Drug Administration-approved prescribing information...
December 6, 2016: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/27915069/systematic-review-of-the-efficacy-of-particulate-vs-non-particulate-corticosteroids-in-epidural-injections
#6
REVIEW
Priyesh Mehta, Isaac Syrop, Jaspal Ricky Singh, Jonathan Kirschner
OBJECTIVE: To systematically analyze published studies in regards to the comparative efficacy of particulate versus non-particulate corticosteroids for cervical and lumbosacral epidural steroid injections (ESI) in reducing pain and improving function. TYPE: Systematic Review LITERATURE SURVEY: MEDLINE (Ovid), EMBASE, and Cochrane databases were searched from the period of 1950 to December 2015. METHODOLOGY: Criteria for inclusion in this review were: 1) Randomized controlled trials and 2) Retrospective studies comparing particulate versus non-particulate medication in fluoroscopically guided injections using a transforaminal (TF) or interlaminar (IL) approach...
November 30, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27893131/association-between-palliative-care-and-patient-and-caregiver-outcomes-a-systematic-review-and-meta-analysis
#7
Dio Kavalieratos, Jennifer Corbelli, Di Zhang, J Nicholas Dionne-Odom, Natalie C Ernecoff, Janel Hanmer, Zachariah P Hoydich, Dara Z Ikejiani, Michele Klein-Fedyshin, Camilla Zimmermann, Sally C Morton, Robert M Arnold, Lucas Heller, Yael Schenker
Importance: The use of palliative care programs and the number of trials assessing their effectiveness have increased. Objective: To determine the association of palliative care with quality of life (QOL), symptom burden, survival, and other outcomes for people with life-limiting illness and for their caregivers. Data Sources: MEDLINE, EMBASE, CINAHL, and Cochrane CENTRAL to July 2016. Study Selection: Randomized clinical trials of palliative care interventions in adults with life-limiting illness...
November 22, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27888649/prospective-multicenter-evaluation-of-balloon-sinus-dilation-for-treatment-of-pediatric-chronic-rhinosinusitis
#8
Zachary M Soler, Jeffrey S Rosenbloom, Douglas Skarada, Michael Gutman, Mark J Hoy, Shaun A Nguyen
BACKGROUND: Although balloon sinus dilation is a treatment option for adults with chronic rhinosinusitis (CRS), there have been few studies performed in pediatric patients. METHODS: This study was designed as a prospective, multicenter, single-arm investigation. Children (2 to 21 years old) with CRS who had failed medical management were treated with balloon sinus dilation and followed to 6 months postprocedure. RESULTS: Fifty children were treated at 4 centers; 33 participants were 2 to 12 years old (mean ± standard deviation age: 6...
November 26, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27870805/minimum-clinically-important-difference-current-trends-in-the-spine-literature
#9
Andrew S Chung, Anne Copay, Neil Olmscheid, David Campbell, Brock Walker, Norman Chutkan
STUDY DESIGN: Review of the 2011-2015 minimum clinically important difference (MCID)-related publications in Spine, Spine Journal, Journal of Neurosurgery-Spine, and European Spine Journal. OBJECTIVE: To summarize the various determinations of MCID and to analyze its usage in the spine literature of the past 5 years in order to develop a basic reference to help practitioners interpret or utilize MCID. SUMMARY OF BACKGROUND DATA: MCID represents the smallest change in a domain of interest that is considered beneficial to a patient or clinician...
November 18, 2016: Spine
https://www.readbyqxmd.com/read/27859832/comparison-of-anti-interleukin-5-therapies-in-patients-with-severe-asthma-global-and-indirect-meta-analyses-of-randomized-placebo-controlled-trials
#10
Yann Cabon, Nicolas Molinari, Gregory Marin, Isabelle Vachier, Anne Sophie Gamez, Pascal Chanez, Arnaud Bourdin
BACKGROUND: Inconsistent results have been reported regarding IL-5 blockade treatment in asthma. There were no direct between-treatment comparisons. Only differences between each drug and placebo were studied. METHODS: We identified all RCTs with anti-IL5 treatments for asthma patients over the 1990-September 2015 period. RCT were searched on Medline, Cochrane and Embase. At least 50 patients were enrolled in each study. Outcomes considered were: exacerbation rate reduction, FEV1 changes, ACQ-5 improvement, adverse events and serious adverse events...
November 10, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27859410/effects-of-vedolizumab-on-health-related-quality-of-life-in-patients-with-ulcerative-colitis-results-from-the-randomised-gemini-1-trial
#11
B G Feagan, H Patel, J-F Colombel, D T Rubin, A James, R Mody, K Lasch
BACKGROUND: Health-related quality of life (HRQL) is often diminished in patients with ulcerative colitis. AIM: To evaluate the effects of vedolizumab on HRQL in patients with ulcerative colitis. METHODS: Using maintenance phase data from the GEMINI 1 study, an analysis of covariance model was used to calculate mean differences between the vedolizumab and placebo groups in changes from baseline to week 52 for 3 HRQL instruments: The Inflammatory Bowel Disease Questionnaire (IBDQ), 36-Item Short Form Health Survey (SF-36), and EQ-5D...
January 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27853663/impact-of-surgical-approach-on-clinical-outcomes-in-the-treatment-of-lumbar-pseudarthrosis
#12
R Kirk Owens, Mladen Djurasovic, Charles H Crawford, Steven D Glassman, John R Dimar, Leah Y Carreon
Study Design Retrospective comparative cohort. Objective Pseudarthrosis following fusion for degenerative lumbar spine pathologies remains a substantial problem. Current data shows that patients who develop a pseudarthrosis have suboptimal outcomes. This study evaluates if treatment of pseudarthrosis can be affected by surgical approach. Methods Medical records of 63 female and 65 male patients (mean age 50.37) who were treated for nonunion following lumbar fusion were reviewed. Sixty patients underwent posterolateral fusion (PSF), 18 underwent PSF with transforaminal interbody fusion (TLIF), 32 underwent anterior and posterior spinal fusion (AP), and 24 underwent anterior lumbar interbody fusion (ALIF)...
December 2016: Global Spine Journal
https://www.readbyqxmd.com/read/27851662/improvement-in-srs22r-pain-scores-after-surgery-for-adolescent-idiopathic-scoliosis
#13
Mladen Djurasovic, Steven D Glassman, Daniel J Sucato, Lawrence G Lenke, Charles H Crawford, Leah Y Carreon
STUDY DESIGN: Longitudinal cohort. OBJECTIVE: To investigate whether patients with painful adolescent idiopathic scoliosis experience pain relief with surgical treatment. SUMMARY OF BACKGROUND DATA: Adolescent idiopathic scoliosis (AIS) was previously thought to be a painless condition, but recent studies have shown that a significant proportion of patients have pain. Little information is available regarding pain relief with surgical treatment for AIS...
November 15, 2016: Spine
https://www.readbyqxmd.com/read/27836675/association-of-knee-pain-with-a-reduction-in-thigh-muscle-strength-a-cross-sectional-analysis-including-4553-osteoarthritis-initiative-participants
#14
A Ruhdorfer, W Wirth, F Eckstein
OBJECTIVE: To cross-sectionally determine the quantitative relationship of age-adjusted, sex-specific isometric knee extensor and flexor strength to patient-reported knee pain. METHODS: Difference of thigh muscle strength by age, and that of age-adjusted strength per unit increase on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) knee pain scale, was estimated from linear regression analysis of 4553 Osteoarthritis Initiative (OAI) participants (58% women)...
November 9, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27801950/use-of-the-control-of-allergic-rhinitis-and-asthma-test-caratkids-in-children-and-adolescents-validation-in-dutch
#15
J A M Emons, B M J Flokstra-de Blok, C de Jong, T van der Molen, H K Brand, N J T Arends, R Amaral, J A Fonseca, R Gerth van Wijk
BACKGROUND: Allergic rhinitis and asthma are common and closely related diseases. Recently, a Portugese questionnaire has been developed 'The Control of Allergic Rhinitis and Asthma Test' (CARATkids) that measures disease control of both diseases in children. This study aims to validate the CARATkids in Dutch children and for the first time in adolescents. In addition, to calculate the minimal clinically important difference (MCID). METHODS: A prospective observational study was conducted in an outpatient clinic...
November 1, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27793184/identifying-placebo-responders-and-predictors-of-response-in-osteoarthritis-a-protocol-for-individual-patient-data-meta-analysis
#16
Yu Fu, Monica S M Persson, Archan Bhattacharya, Siew-Li Goh, Joanne Stocks, Marienke van Middelkoop, Sita M A Bierma-Zeinstra, David Walsh, Michael Doherty, Weiya Zhang
BACKGROUND: The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. On average, 75 % of the analgesic effect from OA treatments in clinical trials can be attributed to a placebo response, and this response varies greatly from patient to patient. This individual patient data (IPD) meta-analysis aims to identify placebo responders and the potential determinants of the placebo response in OA...
October 28, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27792107/minimum-clinically-important-difference-and-substantial-clinical-benefit-in-pain-functional-and-quality-of-life-scales-in-failed-back-surgery-syndrome-patients
#17
Ki Byung Park, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, Jun-Hwan Lee, Kyung-Min Shin, Byung-Cheul Shin, Jae-Heung Cho, In-Hyuk Ha
STUDY DESIGN: Prospective observational 1-year study OBJECTIVE.: To determine minimum clinically important difference (MCID) and substantial clinical benefit (SCB) of outcome measures in failed back surgery syndrome (FBSS) patients, as these metrics enable assessment of whether and when an intervention produces clinically meaningful effects in a patient SUMMARY OF BACKGROUND DATA.: Several methods have been devised to quantify clinically important difference, but MCID and SCB for FBSS patients has yet to be determined...
October 25, 2016: Spine
https://www.readbyqxmd.com/read/27789239/minimal-clinically-important-difference-of-berg-balance-scale-in-people-with-multiple-sclerosis
#18
Elisa Gervasoni, Johanna Jonsdottir, Angelo Montesano, Davide Cattaneo
OBJECTIVE: To identify the Minimal Clinically Important Difference (MCID) to define clinically meaningful patient's improvement on the Berg Balance Scale (BBS) in People with Multiple Sclerosis (PwMS) in response to rehabilitation. DESIGN: Cohort study SETTING: Neurorehabilitation institute. PARTICIPANTS: 110 PwMS participated in this study. INTERVENTIONS: This study is comprised of inpatients and outpatients that participated in research on balance and gait rehabilitation...
October 24, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27779601/a-normative-baseline-for-the-srs-22-from-over-1000-healthy-adolescents-in-india-which-demographic-factors-affect-outcome
#19
Kushagra Verma, Senthil T Nathan, Carly D Comer, Baron Lonner, Suken A Shah
STUDY DESIGN: Prospective Analysis OBJECTIVE.: This study aims to: 1) establish a baseline for the SRS-22 in South East Asia and 2) evaluate the influence of patient demographics on the SRS-22. SUMMARY OF BACKGROUND DATA: Previous studies have established a baseline for the SRS-22 in the US and described the impact of patient demographics. While the SRS-22 is used internationally, limited normative data is available. METHODS: After approval from the local hospital and school board, 1200 adolescents (age 10-18) were asked to anonymously complete the SRS-22 in English...
October 24, 2016: Spine
https://www.readbyqxmd.com/read/27769839/responsiveness-of-the-active-wrist-joint-position-sense-test-after-distal-radius-fracture-intervention
#20
Christos Karagiannopoulos, Michael Sitler, Susan Michlovitz, Carole Tucker, Ryan Tierney
STUDY DESIGN: Prospective cohort study. INTRODUCTION: The active wrist joint position sense (JPS) test has been determined to be a clinically useful test for assessing wrist sensorimotor (SM) status after distal radius fracture (DRF). Its responsiveness is yet to be determined. PURPOSE OF THE STUDY: Primary study aim was to determine the active wrist JPS test responsiveness to detect change in wrist SM status at 8 and 12 weeks after DRF treatment intervention...
October 18, 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
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