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https://www.readbyqxmd.com/read/28421679/thomas-starzl-visionary-and-xenotransplantation-pioneer-commentary-from-the-international-xenotransplant-association-vanguard-committee
#1
Wayne J Hawthorne, Arielle Cimeno, Mohamed Ezzelarab, Bynvant Sandhu, Christopher Burlak
No abstract text is available yet for this article.
March 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28417493/editorial-clinical-benefits-of-vitamin-d-therapy-in-inflammatory-bowel-disease
#2
EDITORIAL
A B Hawthorne
No abstract text is available yet for this article.
May 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28414468/1-3-dipolar-cycloaddition-reactions-of-low-valent-rhodium-and-iridium-complexes-with-arylnitrile-n-oxides
#3
Ilke Ugur Marion, Sesil Agopcan Cinar, Burcu Dedeoglu, Viktorya Aviyente, M Frederick Hawthorne, Peng Liu, Fang Liu, Kendall N Houk, Gonzalo Jiménez-Osés
The reactions between low-valent Rh(I) and Ir(I) metal-carbonyl complexes and arylnitrile oxides possess the electronic and structural features of 1,3-dipolar cycloadditions. Density functional theory (DFT) calculations on these reactions, involving both cyclopentadienyl and carboranyl ligands on the metal carbonyl, explain the ease of the chemical processes and the stabilities of the resulting metallaisoxazolin-5-ones. The metal-carbonyl bond has partial double bond character according to the Wiberg index calculated through NBO analysis, and so the reaction can be considered a normal 1,3-dipolar cycloadditions involving M=C bonds...
April 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28412449/targeted-drug-delivery-system-to-neural-cells-utilizes-the-nicotinic-acetylcholine-receptor
#4
Rachel Huey, Barry O'Hagan, Paul McCarron, Susan Hawthorne
Drug delivery to the brain is still a major challenge in the field of therapeutics, especially for large and hydrophilic compounds. In order to achieve drug delivery of therapeutic concentration in the central nervous system, the problematic blood brain barrier (BBB) must be overcome. This work presents the formulation of a targeted nanoparticle-based drug delivery system using a specific neural cell targeting ligand, rabies virus derived peptide (RDP). Characterization studies revealed that RDP could be conjugated to drug-loaded PLGA nanoparticles of average diameter 257...
April 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28375974/creation-and-validation-of-a-photonumeric-scale-to-assess-volume-deficiency-in-the-infraorbital-region
#5
François Niforos, Steven Liew, Raj Acquilla, Patricia Ogilvie, Marva Safa, Massimo Signorini, Derek Jones, Jan Hawthorn, Caroline Collins, Graeme Kerson, Myooran Sithamparanathan
BACKGROUND: The eyes are particularly important aesthetic features of the face and revitalization of the infraorbital region has become a focus of aesthetic treatments. Published infraorbital scales to date have limitations in that they have been descriptive, subjective, or have used computer-generated images. Thus, there is an unmet need for a validated scale based on actual images. OBJECTIVE: To develop a practical photonumeric scale that respects the complex anatomy and age-related changes occurring in the orbital area...
April 3, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28357138/growth-of-infants-with-intestinal-failure-or-feeding-intolerance-does-not-follow-standard-growth-curves
#6
Danielle L Morton, Keli M Hawthorne, Carolyn E Moore
Objective. Infants with intestinal failure or feeding intolerance are nutritionally compromised and are at risk for extrauterine growth restriction. The aim of the study was to evaluate growth velocities of infants with intestinal failure and feeding intolerance for the first three months of age and to determine growth percentiles at birth and at 40-week postmenstrual age (PMA). Methods. A chart review of infants followed by the Texas Children's Hospital Intestinal Rehabilitation Team was conducted from April 2012 to October 2014...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28351843/five-minutes-with-kamila-hawthorne
#7
Abi Rimmer
No abstract text is available yet for this article.
March 28, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28337770/hypoglycemic-effect-of-hawthorn-in-type-ii-diabetes-mellitus-rat-model
#8
Aili Aierken, Tina Buchholz, Chen Chen, Xiaoying Zhang, Matthias F Melzig
BACKGROUND: Hawthorn is one of the popular herbs in many different traditional medicine systems including in Traditional Chinese Medicine (TCM), where it has long been used for the treatment of hyperglycemia. However, most of its varied biological activities are still remaining unexplored. This study investigated the hypoglycemic effect of hawthorn extracts in type II diabetic (T2DM) rat model. A total of 54 rats were randomly divided into six groups. Normal control group (NC), type II diabetic model group (T2DM, T2DM rats were induced by high fat diet and streptozotocin), high, middle and low concentrations of hawthorn treat groups (HTH , HTM and HTL , T2DM rats were given hawthorn extract at the dose of 50, 100 and 200 mg kg ^-1...
March 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28334260/implicating-abc-transporters-in-insecticide-resistance-research-strategies-and-a-decision-framework
#9
Ryan C Gott, Grace R Kunkel, Emily S Zobel, Brian R Lovett, David J Hawthorne
Pest insects damage crops, transmit diseases, and are household nuisances. Historically, they have been controlled with insecticides, but overuse often leads to resistance to one or more of these chemicals. Insects gain resistance to insecticides through behavioral, metabolic, genetic, and physical mechanisms. One frequently overlooked strategy is through the use of ATP-binding cassette (ABC) transporters. ABC transporters, present in all domains of life, perform natural excretory functions, thus the exploitation of these transporters to excrete insecticides and contribute to resistance is highly plausible...
April 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28331589/complex-variation-in-habitat-selection-strategies-among-individuals-driven-by-extrinsic-factors
#10
Edward J Raynor, Hawthorne L Beyer, John M Briggs, Anthony Joern
Understanding behavioral strategies employed by animals to maximize fitness in the face of environmental heterogeneity, variability, and uncertainty is a central aim of animal ecology. Flexibility in behavior may be key to how animals respond to climate and environmental change. Using a mechanistic modeling framework for simultaneously quantifying the effects of habitat preference and intrinsic movement on space use at the landscape scale, we investigate how movement and habitat selection vary among individuals and years in response to forage quality-quantity tradeoffs, environmental conditions, and variable annual climate...
March 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28316247/correction-to-huey-rachel-hawthorne-susan-the-potential-use-of-rabies-virus-glycoprotein-derived-peptides-to-facilitate-drug-delivery-into-the-central-nervous-system-a-mini-review
#11
(no author information available yet)
No abstract text is available yet for this article.
March 19, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28302682/gp-training-in-mental-health-needs-urgent-reform
#12
EDITORIAL
Elizabeth England, Vicki Nash, Kamila Hawthorne
No abstract text is available yet for this article.
March 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28284186/phytochemical-compositions-of-extract-from-peel-of-hawthorn-fruit-and-its-antioxidant-capacity-cell-growth-inhibition-and-acetylcholinesterase-inhibitory-activity
#13
Panpan Wu, Fajie Li, Jianyong Zhang, Bin Yang, Zhaojie Ji, Weidong Chen
BACKGROUND: Hawthorn fruit (HF) is a well-known traditional medicine in China with the effects of improving digestion and regulating qi-flowing for removing blood stasis. Modern pharmacological experiments showed that HF extract has various pharmaceutical properties and flavonoids are considered as the main bioactive compounds. In this paper, Diaion HP-20 adsorption chromatography was used to enrich flavonoids in PHF, and the phytochemical composition of EPHF was analyzed by high performance liquid chromatography (HPLC) and liquid chromatography tandem mass spectrometry (LC-MS)...
March 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28277037/fruit-extract-of-the-medicinal-plant-crataegus-oxyacantha-exerts-genotoxic-and-mutagenic-effects-in-cultured-cells
#14
Ana Paula Oliveira de Quadros, Dania Elisa Christofoletti Mazzeo, Maria Aparecida Marin-Morales, Fábio Ferreira Perazzo, Paulo Cesar Pires Rosa, Edson Luis Maistro
Crataegus oxyacantha, a plant of the Rosaceae family also known "English hawthorn, haw, maybush, or whitethorn," has long been used for medicinal purposes such as digestive disorders, hyperlipidemia, dyspnea, inducing diuresis, and preventing kidney stones. However, the predominant use of this plant has been to treat cardiovascular disorders. Due to a lack of studies on the genotoxicity of C. oxyacantha, this investigation was undertaken to determine whether its fruit extract exerts cytotoxic, genotoxic, or clastogenic/aneugenic effects in leukocytes and HepG2 (liver hepatocellular carcinoma) cultured human cells, or mutagenic effects in TA100 and TA98 strains of Salmonella typhimurium bacterium...
February 17, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28274254/the-use-of-randomisation-based-efficacy-estimators-in-non-inferiority-trials
#15
David Gillespie, Daniel Farewell, Peter Barrett-Lee, Angela Casbard, Anthony Barney Hawthorne, Chris Hurt, Nick Murray, Chris Probert, Rachel Stenson, Kerenza Hood
BACKGROUND: In a non-inferiority (NI) trial, analysis based on the intention-to-treat (ITT) principle is anti-conservative, so current guidelines recommend analysing on a per-protocol (PP) population in addition. However, PP analysis relies on the often implausible assumption of no confounders. Randomisation-based efficacy estimators (RBEEs) allow for treatment non-adherence while maintaining a comparison of randomised groups. Fischer et al. have developed an approach for estimating RBEEs in randomised trials with two active treatments, a common feature of NI trials...
March 9, 2017: Trials
https://www.readbyqxmd.com/read/28245700/home-based-outpatient-telepsychiatry-to-improve-adherence-with-treatment-appointments-a-pilot-study
#16
Matisyahu Shulman, Majnu John, John M Kane
OBJECTIVE: This study examined whether patients who had been nonadherent with outpatient appointments and who were randomly assigned to receive treatment through a telepsychiatry intervention (home-based video teleconferencing) would show improvement in adherence to appointments, compared with a treatment-as-usual group. METHODS: Participants (N=22) were randomly assigned to home-based video teleconferencing or to outpatient treatment as usual during a six-month study...
March 1, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28203288/nebivolol-versus-other-beta-blockers-in-patients-with-hypertension-and-erectile-dysfunction
#17
REVIEW
Randall P Sharp, Barry J Gales
Erectile dysfunction (ED) impacts over 100 million men worldwide and occurs at a higher incidence in men with hypertension. Beta blockers are one of several antihypertensive drug classes associated with ED. Nebivolol is a beta blocker with vasodilating properties mediated through endothelial release of nitric oxide which facilitates penile erection. Thus, nebivolol may offer an advantage over other beta blockers in the patient with hypertension and ED. A literature search comparing nebivolol with other beta blockers identified four European studies of limited duration, with the longest study being 28 weeks...
February 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/28165796/crohn-s-disease-for-the-general-physician-management
#18
J J Barlow, A B Hawthorne
Crohn's disease presents to general physicians in a variety of ways. The previous article outlined clinical features and initial investigations, and this article covers management of Crohn's disease, including monitoring and drug toxicity.
February 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28165787/crohn-s-disease-for-the-general-physician-presentation-and-investigations
#19
J J Barlow, A B Hawthorne
Crohn's disease presents to general physicians in a variety of ways. This article outlines the clinical features and initial investigation of suspected Crohn's disease. The accompanying article reviews treatment strategies.
February 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28161628/application-of-biochar-and-nitrogen-influences-fluxes-of-co2-ch4-and-n2o-in-a-forest-soil
#20
Iain Hawthorne, Mark S Johnson, Rachhpal S Jassal, T Andrew Black, Nicholas J Grant, Sean M Smukler
Nitrogen (N) fertilization of forests for increasing carbon sequestration and wood volume is expected to influence soil greenhouse gas (GHG) emissions, especially to increase N2O emissions. As biochar application is known to affect soil GHG emissions, we investigated the effect of biochar application, with and without N fertilization, to a forest soil on GHG emissions in a controlled laboratory study. We found that biochar application at high (10%) application rates increased CO2 and N2O emissions when applied without urea-N fertilizer...
February 2, 2017: Journal of Environmental Management
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