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https://www.readbyqxmd.com/read/28735354/transplantation-sites-for-human-and-murine-islets
#1
Rebecca A Stokes, Kim Cheng, Amit Lalwani, Michael M Swarbrick, Helen E Thomas, Thomas Loudovaris, Tom W Kay, Wayne J Hawthorne, Philip J O'Connell, Jenny E Gunton
AIMS/HYPOTHESIS: Beta cell replacement is a potential cure for type 1 diabetes. In humans, islet transplants are currently infused into the liver via the portal vein, although this site has disadvantages. Here, we investigated alternative transplantation sites for human and murine islets in recipient mice, comparing the portal vein with quadriceps muscle and kidney, liver and spleen capsules. METHODS: Murine islets were isolated from C57BL6/J mice and transplanted into syngeneic recipients...
July 22, 2017: Diabetologia
https://www.readbyqxmd.com/read/28734125/a-systematic-review-and-meta-analysis-of-cold-in-situ-perfusion-and-preservation-of-the-hepatic-allograft-working-towards-a-unified-approach
#2
REVIEW
Ahmer M Hameed, Jerome M Laurence, Vincent W T Lam, Henry C Pleass, Wayne J Hawthorne
BACKGROUND: The efficacy of cold in situ perfusion and static storage of the liver is one possible determinant of transplantation outcomes. The aim of this study was to determine whether there is evidence to substantiate a preference for a particular perfusion route (aortic or dual) or perfusion/preservation solution in donation after brain-death (DBD) liver transplantation. METHODS: The Embase, Medline and Cochrane databases were utilized (1980-2017). Random effects modeling was used to estimate effects on transplantation outcomes based upon (i) aortic or dual in situ perfusion, and (ii) the use of University of Wisconsin (UW), histidine-tryptophan-ketoglutarate (HTK), Celsior and/or Institut Georges Lopez-1 (IGL-1) for perfusion/preservation...
July 22, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28730558/transplantation-sites-for-porcine-islets
#3
Rebecca A Stokes, Denbigh M Simond, Heather Burns, Anita T Patel, Philip J O'Connell, Jenny E Gunton, Wayne J Hawthorne
AIMS/HYPOTHESIS: Xenotransplantation has great potential to provide beta cell replacement and thereby provide a cure for large numbers of people with type 1 diabetes. Crucial to the success of xenotransplantation is establishment of the most viable sites for transplantation. METHODS: We compared porcine islet tissue transplanted into kidney, liver and spleen in pig recipients as assessed by blood glucose levels and IVGTT. RESULTS: Kidney was the superior site for porcine islet tissue transplantation, followed by liver then spleen...
July 21, 2017: Diabetologia
https://www.readbyqxmd.com/read/28716486/the-impact-of-a-peer-support-group-for-children-with-rheumatic-heart-disease-in-uganda
#4
Amy Scheel, Andrea Beaton, Emmy Okello, Chris T Longenecker, Isaac Omara Otim, Peter Lwabi, Craig Sable, Allison R Webel, Twalib Aliku
OBJECTIVE: To assess the impact of a peer-support group on knowledge, quality of life, and social support for children with rheumatic heart disease (RHD). METHODS: Children diagnosed with RHD and receiving 4-weekly injectable penicillin were invited to participate in a monthly support group for 6 months. Pre- and post-intervention assessments included a baseline RHD knowledge assessment, a measure of health related quality of life (HRQOL) (PedsQLTM4.0), and a measure of social support (Hawthorne Friendship Scale)...
July 11, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28710433/high-density-genetic-linkage-map-construction-and-quantitative-trait-locus-mapping-for-hawthorn-crataegus-pinnatifida-bunge
#5
Yuhui Zhao, Kai Su, Gang Wang, Liping Zhang, Jijun Zhang, Junpeng Li, Yinshan Guo
Genetic linkage maps are an important tool in genetic and genomic research. In this study, two hawthorn cultivars, Qiujinxing and Damianqiu, and 107 progenies from a cross between them were used for constructing a high-density genetic linkage map using the 2b-restriction site-associated DNA (2b-RAD) sequencing method, as well as for mapping quantitative trait loci (QTL) for flavonoid content. In total, 206,411,693 single-end reads were obtained, with an average sequencing depth of 57× in the parents and 23× in the progeny...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28686738/correction-assessment-of-chronic-sublethal-effects-of-imidacloprid-on-honey-bee-colony-health
#6
Galen P Dively, Michael S Embrey, Alaa Kamel, David J Hawthorne, Jeffery S Pettis
[This corrects the article DOI: 10.1371/journal.pone.0118748.].
2017: PloS One
https://www.readbyqxmd.com/read/28685913/could-phase-3-medicine-trials-be-tagged-as-pragmatic-a-case-study-the-salford-copd-trial
#7
Rafael Dal-Ré
Randomized clinical trials (RCTs) can be classified as explanatory or pragmatic. Currently, explanatory and pragmatic are considered to be the extremes of a continuum: Many trials have some features of both explanatory and pragmatic RCTs. The Salford Chronic Obstructive Respiratory Disease (COPD) trial was an open-label phase 3 RCT assessing an experimental product (fluticasone furoate-vilanterol) vs usual care. The Salford investigators labelled it as "the world's first phase 3 pragmatic RCT" in COPD patients...
July 7, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28683435/validation-and-comparison-of-the-therapeutic-efficacy-of-boron-neutron-capture-therapy-mediated-by-boron-rich-liposomes-in-multiple-murine-tumor-models
#8
Charles A Maitz, Aslam A Khan, Peter J Kueffer, John D Brockman, Jonathan Dixson, Satish S Jalisatgi, David W Nigg, Thomas A Everett, M Frederick Hawthorne
Boron neutron capture therapy (BNCT) was performed at the University of Missouri Research Reactor in mice bearing CT26 colon carcinoma flank tumors and the results were compared with previously performed studies with mice bearing EMT6 breast cancer flank tumors. Mice were implanted with CT26 tumors subcutaneously in the caudal flank and were given two separate tail vein injections of unilamellar liposomes composed of cholesterol, 1,2-distearoyl-sn-glycer-3-phosphocholine, and K[nido-7-CH3(CH2)15-7,8-C2B9H11] in the lipid bilayer and encapsulated Na3[1-(2`-B10H9)-2-NH3B10H8] within the liposomal core...
July 3, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28674384/impact-of-climate-and-host-availability-on-future-distribution-of-colorado-potato-beetle
#9
Cong Wang, David Hawthorne, Yujia Qin, Xubin Pan, Zhihong Li, Shuifang Zhu
Colorado Potato Beetle (CPB) is a devastating invasive pest of potato both in its native North America and now across Eurasia. It also damages eggplant, tomato and feeds on several wild species in the Solanaceae, such as S. eleagnifolium and S. rostratum Dunal (SR). Since first categorized as a pest in 1864, CPB has spread rapidly across North America, Europe and Asia. In light of its invasiveness and economic importance, it is necessary to study how climate change and host availability may alter the distribution of the CPB...
July 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28670982/meeting-the-demand-of-the-future-a-curriculum-to-stimulate-interest-in-careers-in-primary-care-internal-medicine
#10
Mary R Hawthorne, An Dinh
BACKGROUND: There is a growing need for primary care physicians, but only a small percentage of graduating medical students enter careers in primary care. PURPOSE: To assess whether a Primary Care Intraclerkship within the Medicine clerkship can significantly improve students' attitudes by analyzing scores on pre- and post-tests. METHODS: Students on the Medicine clerkship at the University of Massachusetts Medical School participated in full-day 'intraclerkships',to demonstrate the importance of primary care and the management of chronic illness in various primary care settings...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28651037/fusing-dicarbollide-ions-with-n-heterocyclic-carbenes
#11
Jess Estrada, Vincent Lavallo
Discovered by Hawthorne in 1965, dicarbollide ions are an intriguing class of nido-carboranes that mimic the behavior of the cyclopentadienyl anion. Here we show that it is possible to directly link the dicarbollide ion to an N-Heterocyclic Carbene (NHC), to form an isolable N-dicarbollide NHC dianion. This molecule can be accessed via the sequential double deprotonation of a mono-nido-carboranyl imidazolium zwitterion. As revealed by a single crystal x-ray diffraction study, the first deprotonation leads to a monoanionic dicarbollide ion that adopts a bis(dicarbollide) structure in the solid-state...
June 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28646833/the-use-of-fruit-extracts-for-production-of-apple-chips-with-enhanced-antioxidant-activity
#12
Tomasz Tarko, Aleksandra Duda-Chodak, Dorota Semik-Szczurak
Background: Style and pace of life make consumers more willing to reach for snack products. This group of processed food includes, among others, fruit chips. Due to the increasing incidence of diseases associated with the excessive exposure to free radicals foods enriched with antioxidant compounds, eg. polyphenols, can be introduced into the sale. Objective: The aim of the study was to use the fruit extracts for the production of apple chips with enhanced antioxidant activity...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28608832/fruits-for-prevention-and-treatment-of-cardiovascular-diseases
#13
REVIEW
Cai-Ning Zhao, Xiao Meng, Ya Li, Sha Li, Qing Liu, Guo-Yi Tang, Hua-Bin Li
Cardiovascular diseases (CVDs) are leading global health problems. Accumulating epidemiological studies have indicated that consuming fruits was inversely related to the risk of CVDs. Moreover, substantial experimental studies have supported the protective role of fruits against CVDs, and several fruits (grape, blueberry, pomegranate, apple, hawthorn, and avocado) have been widely studied and have shown potent cardiovascular protective action. Fruits can prevent CVDs or facilitate the restoration of morphology and functions of heart and vessels after injury...
June 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28594760/an-initiative-to-reduce-the-episiotomy-rate-association-of-feedback-and-the-hawthorne-effect-with-leapfrog-goals
#14
Kathy Zhang-Rutledge, Steven L Clark, Stacie Denning, Audra Timmins, Gary A Dildy, Manisha Gandhi
OBJECTIVE: To assess the association of education, performance feedback, and the Hawthorne effect with a reduction in the episiotomy rate in a large academic institution. METHODS: We describe a prospective observational study of a project conducted between March 2012 and February 2017 to assist clinicians in meeting the Leapfrog Group (www.leapfroggroup.org) target rates for episiotomy. Phases of this project included preintervention (phase 1, March 2012 to April 2014), education and provision of collective department episiotomy rates (phase 2, May 2014 to December 2014), ongoing education with emphasis on a revised Leapfrog target rate (phase 3, January 2015 to February 2016), and provision of individual episiotomy rates to practitioners on a monthly basis (phase 4, March 2016 to February 2017)...
June 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28590220/effect-of-common-species-of-florida-landscaping-plants-on-the-efficacy-of-attractive-toxic-sugar-baits-against-aedes-albopictus
#15
Kelly E Seeger, Jodi M Scott, Gunter C Muller, Whitney A Qualls, Rui-De Xue
Attractive toxic sugar bait (ATSB) was applied to 5 different types of commonly found plants in landscaping of northeastern Florida. The ATSB applications were assessed for possible plant effects and preference against Aedes albopictus in semifield evaluations. Positive and negative controls consisted of plants sprayed with attractive sugar bait (no toxicant) and plants with nothing applied. Bioassays were conducted on stems with leaf clippings and on full plants to assess any difference in mosquito mortality on the different plants...
June 2017: Journal of the American Mosquito Control Association
https://www.readbyqxmd.com/read/28583362/on-the-narrative-form-of-simulations
#16
M Norton Wise
Understanding complex physical systems through the use of simulations often takes on a narrative character. That is, scientists using simulations seek an understanding of processes occurring in time by generating them from a dynamic model, thereby producing something like a historical narrative. This paper focuses on simulations of the Diels-Alder reaction, which is widely used in organic chemistry. It calls on several well-known works on historical narrative to draw out the ways in which use of these simulations mirrors aspects of narrative understanding: Gallie for "followability" and "contingency"; Mink for "synoptic judgment"; Ricoeur for "temporal dialectic"; and Hawthorn for a related dialectic of the "actual and the possible"...
April 2017: Studies in History and Philosophy of Science
https://www.readbyqxmd.com/read/28544075/dual-kidney-transplant-techniques-a-systematic-review
#17
Annelise Cocco, Sara Shahrestani, Nicholas Cocco, Ahmer Hameed, Lawrence Yuen, Brendan Ryan, Wayne Hawthorne, Vincent Lam, Henry Pleass
BACKGROUND: Dual kidney transplantation (DKT) was developed in order to improve outcomes from transplantation of extended criteria donors (ECD). This paper examined which surgical techniques have been reported for DKT, and whether any technique had superior patient and graft survival. METHOD: Electronic databases were searched for published studies mapping to MESH terms: ''kidney or renal" AND "transplan*" AND "dual or double". Single case reports; studies of patients less than 18 years old; studies which did not describe the surgical technique; and studies that did not report patient or graft survival were excluded...
May 23, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28539730/near-infrared-spectroscopy-as-a-process-analytical-technology-tool-for-monitoring-the-parching-process-of-traditional-chinese-medicine-based-on-two-kinds-of-chemical-indicators
#18
Kaiyue Li, Weiying Wang, Yanping Liu, Su Jiang, Guo Huang, Liming Ye
BACKGROUND: The active ingredients and thus pharmacological efficacy of traditional Chinese medicine (TCM) at different degrees of parching process vary greatly. OBJECTIVE: Near-infrared spectroscopy (NIR) was used to develop a new method for rapid online analysis of TCM parching process, using two kinds of chemical indicators (5-(hydroxymethyl) furfural [5-HMF] content and 420 nm absorbance) as reference values which were obviously observed and changed in most TCM parching process...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28535421/differentiation-of-crataegus-spp-guided-by-nuclear-magnetic-resonance-spectrometry-with-chemometric-analyses
#19
Jensen A Lund, Paula N Brown, Paul R Shipley
For compliance with US Current Good Manufacturing Practice regulations for dietary supplements, manufacturers must provide identity of source plant material. Despite the popularity of hawthorn as a dietary supplement, relatively little is known about the comparative phytochemistry of different hawthorn species, and in particular North American hawthorns. The combination of NMR spectrometry with chemometric analyses offers an innovative approach to differentiating hawthorn species and exploring the phytochemistry...
September 2017: Phytochemistry
https://www.readbyqxmd.com/read/28533575/antihypertensive-effects-of-hydroalcoholic-extract-of-crataegus-azarolus-subspecies-aronia-fruit-in-rats-with-renovascular-hypertension-an-experimental-mechanistic-study
#20
Mohammad Reza Haydari, Mohammad Reza Panjeshahin, Elaheh Mashghoolozekr, Ali Akbar Nekooeian
BACKGROUND: Hawthorn species decreases blood pressure and relaxes precontracted vessels. This study aimed at examining the antihypertensive effect and related mechanisms of hydroalcoholic extract of Crataegus azarolus subspecies aronia fruit in rats with renovascular hypertension. METHODS: Six groups of male Sprague-Dawley rats, each containing 6 to 8 rats, were studied. The groups comprised of one sham group and 5 renal artery-clipped groups. The sham group received vehicle (distilled water 0...
May 2017: Iranian Journal of Medical Sciences
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