keyword
MENU ▼
Read by QxMD icon Read
search

tumor associated macrophage

keyword
https://www.readbyqxmd.com/read/29055087/metabolism-and-tam-functions-it-takes-two-to-tango
#1
REVIEW
Massimiliano Mazzone, Alessio Menga, Alessandra Castegna
From the evidence on clinical studies and experimental mouse models we now know that tumor associated macrophages (TAMs) sustain tumor development in many different ways. They play a role in angiogenesis, tumor cell invasion and metastasis formation. Additionally, TAMs interfere with natural killer and T cell antitumoral activities, producing an immune suppressive environment that protects tumor cell growth. This indicates that the tumoricidal activity of macrophages within the tumor microenviroment is lost due to an imbalance of the regulatory mechanisms underpinning these cells' function...
October 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29055014/protein-acyltransferase-dhhc3-regulates-breast-tumor-growth-oxidative-stress-and-senescence
#2
Martin E Hemler, Chandan Sharma, Hong-Xing Wang, Qinglin Li, Konstantin Knoblich, Emily S Reisenbichler, Andrea L Richardson
DHHC-type protein acyltransferases may regulate the localization, stability and/or activity of their substrates. In this study, we show that the protein palmitoyltransferase DHHC3 is upregulated in malignant and metastatic human breast cancer. Elevated expression of DHHC3 correlated with diminished patient survival in breast cancer and six other human cancer types. ZDHHC3 ablation in human MDA-MB-231 mammary tumor cell xenografts reduced the sizes of both the primary tumor and metastatic lung colonies. Gene array data and fluorescence dye assays documented increased oxidative stress and senescence in ZDHHC3-ablated cells...
October 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/29055013/a-synthetic-cd8%C3%AE-myd88-co-receptor-enhances-cd8-t-cell-responses-to-weakly-immunogenic-and-lowly-expressed-tumor-antigens
#3
Sabina Kaczanowska, Ann Mary Joseph, Jitao Guo, Alexander K Tsai, Jackline Joy M Lasola, Kenisha Younger, Yuji Zhang, Cruz Velasco Gonzalez, Eduardo Davila
T cell-based immunotherapies are a promising approach for patients with advanced cancers. However, various obstacles limit T cell efficacy, including suboptimal T cell receptor (TCR) activation and an immunosuppressive tumor environment. Here we developed a fusion protein by linking CD8α and MyD88 (CD8α:MyD88) to enhance CD8+ T cell responses to weakly immunogenic and poorly expressed tumor antigens. CD8α:MyD88-engineered T cells exhibited increased proliferation and expression of effector and co-stimulatory molecules in a tumor antigen-dependent manner...
October 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/29054599/indoleamine-2-3-dioxygenase-expression-in-primary-cutaneous-melanoma-correlates-with-breslow-thickness-and-is-of-significant-prognostic-value-for-progression-free-survival
#4
Felicia Rubel, Johannes S Kern, Kristin Technau-Hafsi, Sibylle Uhrich, Kaethe Thoma, Georg Häcker, Nikolas von Bubnoff, Frank Meiss, Dagmar von Bubnoff
The enzyme indoleamine 2,3-dioxygenase (IDO) is emerging as a facilitator of cancer development through its effects on cancer-associated inflammation. Recent studies report a significant improvement of the response rates in melanoma patients to PD-1 antibodies when IDO-inhibitors were added to the regimen. Data on IDO-expression in primary human melanomas are however incomplete and conflicting. Here, we show that the level of IDO-expression in primary human melanoma cells significantly correlates with Breslow thickness (p = 0...
October 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29051319/ccl26-participates-in-the-prl-3-induced-promotion-of-colorectal-cancer-invasion-by-stimulating-tumor-associated-macrophage-infiltration
#5
Qiusheng Lan, Wei Lai, Yujie Zeng, Lu Liu, Shoufeng Li, Shaowen Jin, Yang Zhang, Xingxi Luo, Heyang Xu, Xiangan Lin, Zhonghua Chu
Both phosphatase of regenerating liver-3 (PRL-3) and tumor-associated macrophages (TAMs) influence cancer progression. Whether PRL-3 plays a critical role in colorectal cancer (CRC) invasion and metastasis by inducing TAM infiltration remains unclear. In the present study, we investigated the effects of chemokine ligand 26 (CCL26) on TAM infiltration and CRC invasion and the underlying mechanism in CRC cells by overexpressing or silencing PRL-3. We found that PRL-3 up-regulated CCL26 expression correlatively and participated in cell migration, according to the results of gene ontology analysis...
October 19, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29051064/harnessing-the-cross-talk-between-tumor-cells-and-tumor-associated-macrophages-with-a-nano-drug-for-modulation-of-glioblastoma-immune-microenvironment
#6
Tong-Fei Li, Ke Li, Chao Wang, Xin Liu, Yu Wen, Yong-Hong Xu, Quan Zhang, Qiu-Ya Zhao, Ming Shao, Yan-Ze Li, Min Han, Naoki Komatsu, Li Zhao, Xiao Chen
Glioblastoma (GBM) is the most frequent and malignant brain tumor with a high mortality rate. The presence of a large population of macrophages (Mφ) in the tumor microenvironment is a prominent feature of GBM and these so-called tumor-associated Mφ (TAM) closely interact with the GBM cells to promote the survival, progression and therapy resistance of the GBM. Various therapeutic strategies have been devised either targeting the GBM cells or the TAM but few have addressed the cross-talks between the two cell populations...
October 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29048623/vegfr3-inhibition-chemosensitizes-lung-adenocarcinoma-a549-cells-in-the-tumor-associated-macrophage-microenvironment-through-upregulation-of-p53-and-pten
#7
Ya Li, Yaguang Weng, Liang Zhong, Huimin Chong, Sicheng Chen, Yanting Sun, Wang Li, Qiong Shi
In lung adenocarcinoma, loss of p53 and PTEN in tumors are associated with decreased response to chemotherapy and decreased survival. A means to pharmacologically upregulate p53 and PTEN protein expression could improve the prognosis of patients with p53- and PTEN-deficient tumors. In the present study we revealed that vascular endothelial growth factor receptor 3 (VEGFR3) inhibition in lung adenocarcinoma cells was associated with improved expression levels of both p53 and PTEN in the tumor-associated macrophage (TAM) microenvironment...
September 19, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29048388/regulatory-t-cells-and-tumor-associated-macrophages-in-the-tumor-microenvironment-in-non-muscle-invasive-bladder-cancer-treated-with-intravesical-bacille-calmette-gu%C3%A3-rin-a-long-term-follow-up-study-of-a-japanese-cohort
#8
Makito Miyake, Yoshihiro Tatsumi, Daisuke Gotoh, Sayuri Ohnishi, Takuya Owari, Kota Iida, Kenta Ohnishi, Shunta Hori, Yosuke Morizawa, Yoshitaka Itami, Yasushi Nakai, Takeshi Inoue, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Keiji Shimada, Noboru Konishi, Nobumichi Tanaka, Kiyohide Fujimoto
The clinical significance of regulatory T cells (Treg) and tumor-associated macrophages (TAM) in the tumor microenvironment of human bladder cancer remains unclear. The aim of this study is to explore their relevance to oncological features in non-muscle invasive bladder cancer (NMIBC). We carried out immunohistochemical analysis of forkhead box P3 (FOXP3, Treg maker), CD204 (TAM marker), and interleukin-6 (IL6) using surgical specimens obtained from 154 NMIBC patients. The Treg and TAM counts surrounding the cancer lesion and IL6-positive cancer cell counts were evaluated against clinicopathological variables...
October 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29046432/alk-is-a-therapeutic-target-for-lethal-sepsis
#9
Ling Zeng, Rui Kang, Shan Zhu, Xiao Wang, Lizhi Cao, Haichao Wang, Timothy R Billiar, Jianxin Jiang, Daolin Tang
Sepsis, a life-threatening organ dysfunction caused by infection, is a major public health concern with limited therapeutic options. We provide evidence to support a role for anaplastic lymphoma kinase (ALK), a tumor-associated receptor tyrosine kinase, in the regulation of innate immunity during lethal sepsis. The genetic disruption of ALK expression diminishes the stimulator of interferon genes (STING)-mediated host immune response to cyclic dinucleotides in monocytes and macrophages. Mechanistically, ALK directly interacts with epidermal growth factor receptor (EGFR) to trigger serine-threonine protein kinase AKT phosphorylation and activate interferon regulatory factor 3 (IRF3) and nuclear factor κB (NF-κB) signaling pathways, enabling STING-dependent rigorous inflammatory responses...
October 18, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29044503/clinical-significance-of-programmed-cell-death-ligand-1-expression-and-the-immune-microenvironment-at-the-invasive-front-of-colorectal-cancers-with-high-microsatellite-instability
#10
Shotaro Korehisa, Eiji Oki, Makoto Iimori, Yu Nakaji, Mototsugu Shimokawa, Hiroshi Saeki, Shinji Okano, Yoshinao Oda, Yoshihiko Maehara
Immunotherapy is reportedly effective in colorectal cancers (CRCs) with high microsatellite instability (MSI-H); however, the specific cell types that respond to immune checkpoint therapy are unclear. Herein, we aimed to examine the expression of programmed cell death-ligand 1 (PD-L1) and related proteins in MSI-H and microsatellite-stable (MSS) CRCs to investigate the immune microenvironment at the tumor's invasive front. The MSI status was retrospectively assessed in 499 patients undergoing surgical resection of primary CRC; of these, 48 were classified as MSI-H...
October 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29042640/validation-of-multiplex-immunofluorescence-panels-using-multispectral-microscopy-for-immune-profiling-of-formalin-fixed-and-paraffin-embedded-human-tumor-tissues
#11
Edwin R Parra, Naohiro Uraoka, Mei Jiang, Pamela Cook, Don Gibbons, Marie-Andrée Forget, Chantale Bernatchez, Cara Haymaker, Ignacio I Wistuba, Jaime Rodriguez-Canales
Immune-profiling is becoming an important tool to identify predictive markers for the response to immunotherapy. Our goal was to validate multiplex immunofluorescence (mIF) panels to apply to formalin-fixed and paraffin-embedded tissues using a set of immune marker antibodies, with the Opal™ 7 color Kit (PerkinElmer) in the same tissue section. We validated and we described two panels aiming to characterize the expression of PD-L1, PD-1, and subsets of tumor associated immune cells. Panel 1 included pancytokeratin (AE1/AE3), PD-L1, CD4, CD8, CD3, CD68, and DAPI, and Panel 2 included pancytokeratin, PD-1, CD45RO, granzyme B, CD57, FOXP3, and DAPI...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29039503/inhibitory-effects-of-lupane%C3%A2-type-triterpenoid-saponins-from-the-leaves-of-acanthopanax%C3%A2-gracilistylus-on-lipopolysaccharide-induced-tnf%C3%A2-%C3%AE-il%C3%A2-1%C3%AE-and-high%C3%A2-mobility-group-box-1-release-in-macrophages
#12
Qin-Peng Zou, Xiang-Qian Liu, Jian-Jun Huang, Chang-Soo Yook, Wan-Kyunn Whang, Hyeong-Kyu Lee, Ok-Kyoung Kwon
Acanthopanax gracilistylus (AGS) has long been used in traditional Chinese medicine for the treatment of various inflammatory diseases. 3‑O‑β‑D‑glucopyranosyl 3α, 11α‑dihydroxylup‑20(29)‑en‑28‑oic acid, acantrifoside A, acankoreoside D, acankoreoside B and acankoreoside A are major lupane‑type triterpenoid saponins derived from AGS. In the present study, these five saponins were isolated from AGS by chromatography and their anti‑inflammatory activities were investigated in lipopolysaccharide (LPS)‑treated RAW264...
October 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039447/paralemmin-3-contributes-to-lipopolysaccharide-induced-inflammatory-response-and-is-involved-in-lipopolysaccharide-toll-like-receptor-4-signaling-in-alveolar-macrophages
#13
Xu-Xin Chen, Lu Tang, Yu-Mei Fu, Yi Wang, Zhi-Hai Han, Ji-Guang Meng
Alveolar macrophages (AMs) are the first line of defense against foreign stimulation in alveoli, and they participate in inflammatory responses during acute lung injury (ALI). Previous studies indicated that paralemmin-3 (PALM3) expression is induced by lipopolysaccharides (LPS) and may be involved in LPS-Toll-like receptor 4 (TLR4) signaling in alveolar epithelial cells. The aim of the present study was to investigate the effect of PALM3 on LPS-induced inflammation and its underlying mechanisms in rat AMs...
September 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29038249/anti-pd-1-antibody-treatment-promotes-clearance-of-persistent-cryptococcal-lung-infection-in-mice
#14
Jonathan A Roussey, Steven P Viglianti, Seagal Teitz-Tennenbaum, Michal A Olszewski, John J Osterholzer
Activation of immunomodulatory pathways in response to invasive fungi can impair clearance and promote persistent infections. The programmed cell death protein-1 (PD-1) signaling pathway inhibits immune effector responses against tumors, and immune checkpoint inhibitors that block this pathway are being increasingly used as cancer therapy. The objective of this study was to investigate whether this pathway contributes to persistent fungal infection and to determine whether anti-PD-1 Ab treatment improves fungal clearance...
October 16, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29038174/tumor-associated-macrophages-tams-depend-on-zeb1-for-their-cancer-promoting-roles
#15
Marlies Cortés, Lidia Sanchez-Moral, Oriol de Barrios, María J Fernández-Aceñero, M C Martínez-Campanario, Anna Esteve-Codina, Douglas S Darling, Balázs Győrffy, Toby Lawrence, Douglas C Dean, Antonio Postigo
Accumulation of tumor-associated macrophages (TAMs) associates with malignant progression in cancer. However, the mechanisms that drive the pro-tumor functions of TAMs are not fully understood. ZEB1 is best known for driving an epithelial-to-mesenchymal transition (EMT) in cancer cells to promote tumor progression. However, a role for ZEB1 in macrophages and TAMs has not been studied. Here we describe that TAMs require ZEB1 for their tumor-promoting and chemotherapy resistance functions in a mouse model of ovarian cancer...
October 16, 2017: EMBO Journal
https://www.readbyqxmd.com/read/29034589/involvement-of-local-renin-angiotensin-system-in-immunosuppression-of-tumor-microenvironment
#16
Kenta Nakamura, Tomonori Yaguchi, Gaku Ohmura, Asuka Kobayashi, Naoshi Kawamura, Takashi Iwata, Yukiko Kiniwa, Ryuhei Okuyama, Yutaka Kawakami
To improve the current cancer immunotherapies, strategies to modulate various immunosuppressive cells including myeloid derived suppressor cells (MDSCs) which were shown to be negative factors in the immune-checkpoint blockade therapy, need to be developed. In this study, we have evaluated the role of local renin-angiotensin system (RAS) in the tumor immune-microenvironment using murine models bearing tumor cell lines in which RAS was not involved in their proliferation and angiogenetic ability. Administration of angiotensin II receptor blockers (ARBs) to C57BL/6 mice bearing murine colon cancer cell line MC38 resulted in significant enhancement of tumor antigen gp70 specific T cells...
October 16, 2017: Cancer Science
https://www.readbyqxmd.com/read/29034362/lipid-droplets-potential-biomarker-and-metabolic-target-in-glioblastoma
#17
Feng Geng, Deliang Guo
Lipid droplets (LDs) are subcellular organelles that store large amounts of the neutral lipids, triglycerides (TG) and/or cholesteryl esters (CE). LDs are commonly formed in adipocytes, liver cells and macrophages, and their formation has been shown to be associated with the progression of metabolic diseases, i.e., obesity, fatty liver and atherosclerosis. Interestingly, LDs are also found in some tumor tissues. We recently showed that LDs are prevalent in glioblastoma (GBM), the most deadly brain tumor, but are not detectable in low-grade gliomas and normal brain tissues, suggesting that LDs may serve as a novel diagnostic biomarker for GBM...
May 2017: Internal Medicine Review (Washington, D.C.: Online)
https://www.readbyqxmd.com/read/29033182/pd-l1-expression-in-hnpcc-associated-colorectal-cancer
#18
Naila Shiraliyeva, Jacqueline Friedrichs, Reinhard Buettner, Nicolaus Friedrichs
BACKGROUND: PD-L1 immunohistochemistry is predictive for molecular inhibitors of PD-1/PD-L1 immune checkpoint. Therefore, this study evaluated the PD-L1 expression in patients with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). METHODS: Immunohistochemical expression of PD-L1 in carcinoma cells, stromal macrophages and lymphocytes of 40 HNPCC-patients with colorectal cancer was scored semi-quantitatively. RESULTS: Focal (2 cases) to extensive (2 cases) PD-L1-immunopositivity of carcinoma cells was detected in 4 out of 40 cases (10...
September 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29032985/damp-tlr-cytokine-axis-dictates-the-fate-of-tumor
#19
REVIEW
Ashok Patidar, Sathishkumar Selvaraj, Aditya Sarode, Prashant Chauhan, Debprasad Chattopadhyay, Bhaskar Saha
Random mutations leading to loss of cell cycle control is not a rare occurrence in an organism but the mutated cells are recognized and eliminated preventing the development of a tumor. These potentially tumorigenic cells release damage-associated molecular patterns (DAMPs), which are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells. The initial TLR-DAMP interactions lead to different responses such as altered antigen presentation and cytokine release that directly affect T cell activation and removal of the tumorigenic cells...
October 9, 2017: Cytokine
https://www.readbyqxmd.com/read/29031893/in-an-in%C3%A2-vitro-model-using-human-fetal-membranes-17-alpha-hydroxyprogesterone-caproate-is-not-an-optimal-progestogen-for-inhibition-of-fetal-membrane-weakening
#20
Deepak Kumar, Robert M Moore, Brian M Mercer, Joseph M Mansour, Sam Mesiano, Frederick Schatz, Charles J Lockwood, John J Moore
BACKGROUND: The progestogen 17-alpha hydroxyprogesterone caproate is 1 of only 2 agents recommended for clinical use in the prevention of spontaneous preterm delivery, and studies of its efficacy have been conflicting. We have developed an in vitro model to study the fetal membrane weakening process that leads to rupture in preterm premature rupture of the fetal membranes. Inflammation/infection associated with tumor necrosis factor-alpha induction and decidual bleeding/abruption associated thrombin release are leading causes of preterm premature rupture of the fetal membranes...
October 12, 2017: American Journal of Obstetrics and Gynecology
keyword
keyword
44652
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"