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Sophie M C Gobeil, Donald Gagné, Nicolas Doucet, Joelle N Pelletier
The widespread use of β-lactam antibiotics has given rise to a dramatic increase in clinically-relevant β-lactamases. Understanding the structure/function relation in these variants is essential to better address the ever-growing incidence of antibiotic resistance. We previously reported the backbone resonance assignments of a chimeric protein constituted of segments of the class A β-lactamases TEM-1 and PSE-4 (Morin et al. in Biomol NMR Assign 4:127-130, 2010. doi: 10.1007/s12104-010-9227-8 ). That chimera, cTEM17m, held 17 amino acid substitutions relative to TEM-1 β-lactamase, resulting in a well-folded and fully functional protein with increased dynamics...
April 2016: Biomolecular NMR Assignments
Kone Mongomake, Oumar Doungous, Behnam Khatabi, Vincent N Fondong
A procedure to regenerate cassava (Manihot esculenta Crantz) cultivars from Cameroon via somatic embryogenesis (SE) was developed. Shoot apical meristems and immature leaf lobes were used as explants on Murashige and Skoog (MS) basal medium containing 33 or 50 µM of the auxins Picloram (Pic), 2,4-Dichlorophenoxyacetic acid (2,4-D), Dicamba (Dic), and α-Naphthalene acetic acid. Cultivar performance was assessed using SE and number of somatic embryos produced. Overall, the frequency of primary somatic embryogenesis (PSE) and the mean number of somatic embryos produced varied considerably with genotype, type of auxin and concentration tested...
2015: SpringerPlus
Ki Moon Park, Kyung Min Kwon, Seung Ho Lee
Since mushrooms have many bioactive components, they have been used as components in folk medicine. Because mycelium has an advantage when it comes to large-scale production, this study aimed to evaluate the antioxidant properties and anti-tyrosinase activity from 55 mycelia in culture media. Relatively high 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging capacity was detected from the ethanol extract of culture media including mycelium (EECiM) of Morchella esculenta var. esculenta (MEVE), Auricularia polytricha (APO), Tremella aurantia (TAU), Volvariella bombycina (VBO), and Oudemansiella sp...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
Luke Miller, Matthew Longo, Ayse Saygin
The brain combines information across sensory modalities to construct finely calibrated multisensory models of the body. The parameters of these models are largely dependent upon online sensory feedback, particularly visual. For example, visually magnifying a body part recalibrates somatosensory perception on it. Tool use has also been shown to recalibrate tactile perception on the tool-using limb. Here, we show that vision during tool use is both necessary and sufficient for recalibrating tactile perception...
2015: Journal of Vision
Mark A Miller, Catherine J O'Leary, Paul D Allen, Benjamin T Crane
Vection is an illusory perception of self-motion that can occur when visual motion fills the majority of the visual field. This study examines the effect of the duration of visual field movement (VFM) on the perceived strength of self-motion using an inertial nulling (IN) and a magnitude estimation technique based on the certainty that motion occurred (certainty estimation, CE). These techniques were then used to investigate the association between migraine diagnosis and the strength of perceived vection. Visual star-field stimuli consistent with either looming or receding motion were presented for 1, 4, 8 or 16s...
2015: PloS One
Mehtap Tugrak, Cem Yamali, Hiroshi Sakagami, Halise Inci Gul
Chalcones and Mannich bases are a group of compounds known for their cytotoxicities. In this study restricted chalcone analogue, compound 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one MT1, was used as a starting compound to synthesize new mono Mannich bases since Mannich bases may induce more cytotoxicity than chalcone analogue that they are derived from by producing additional alkylating center for cellular thiols. In this study, cyclic and acyclic amines were used to synthesize Mannich bases. All compounds were tested against Ca9-22 (gingival carcinoma), HSC-2, HSC-3 and HSC-4 (oral squamous cell carcinoma) as tumour cell lines and HGF (gingival fibroblasts), HPC (pulp cells) and HPLF (periodontal ligament fibroblasts) human normal oral cells as non tumour cell lines...
October 2016: Journal of Enzyme Inhibition and Medicinal Chemistry
Ae Wha Ha, Woo Kyoung Kim, Jung Hwan Kim, Nam E Kang
BACKGROUD/OBJECTIVES: This study was conducted in order to investigate the effect of peanut sprout extracts (PSE) on health indices in overweight and obese women (BMI ≥ 23 kg/m(2)). SUBJECTS/METHODS: Subjects were divided into three groups by double-blind randomized trial; the Placebo group (n = 15) and the Low PSE group (2.6 g PSE/day, n = 15), and the High PSE group (5.8 g PSE/day, n = 15). Subjects consumed 12 capsules per day, three times a day, 30 min before meals, for 4 weeks...
June 2015: Nutrition Research and Practice
Xiao-Ran Yan, Wan-Zhen Jiao, Zhi-Wei Li, Wen-Wen Xu, Feng-Jiao Li, Li-Hua Wang
PURPOSE: To assess the accuracy of the Plusoptix A09 photoscreener in detecting amblyopia risk factors in children and determine referral criteria when using Plusoptix A09 for a large-scale vision screening. METHODS: Pediatric patients attending our eye clinic underwent a comprehensive ophthalmic examination that included photorefraction, orthoptic examination, anterior segment assessment, fundus examination and cycloplegic retinoscopy. The measurements were collected for statistical analyses...
2015: PloS One
Trevor J Carden, Jiliang Hang, Patrick H Dussault, Timothy P Carr
BACKGROUND: Elevated concentrations of LDL cholesterol are associated with the development of atherosclerosis and therefore are considered an important target for intervention to prevent cardiovascular diseases. The inhibition of cholesterol absorption in the small intestine is an attractive approach to lowering plasma cholesterol, one that is addressed by drug therapy as well as dietary supplementation with plant sterols and plant sterol esters (PSEs). OBJECTIVE: This study was conducted to test the hypothesis that the cholesterol-lowering effects of PSE require hydrolysis to free sterols (FSs)...
July 2015: Journal of Nutrition
Ae Wha Ha, Nam E Kang, Woo Kyoung Kim
The hypothesis of this study was that peanut sprout extracts (PSE) could reduce fat accumulation through activating the transcription of SREBP-1c genes. Sprague-Dawley (SD) were randomly assigned into two groups and fed the following diet for 4 weeks; 10 normal fat (NF, 7 g of fat/100 g diet) and 30 high fat (HF, 20 g of fat/100 g diet). After 4 weeks, the HF group was divided into three groups; HF, HF with 15 mg of PSE/kg diet (HF+low PSE, 0.025% resveratrol), and HF with 30 mg of PSE/kg diet (HF+high PSE, 0...
August 2015: Journal of Medicinal Food
Hironori Sunakawa, Daisuke Tokuhara, Akira Yamamoto, Satoshi Sugimori, Yoshiki Morotomi, Shino Taniguchi, Masaharu Nakaya, Yuki Cho, Katsutoshi Matsui, Saki Kasuga, Yukari Sakae, Kazumi Yamato, Norifumi Nishida, Sadao Tokimasa, Haruo Shintaku
There is no consensus guidelines for treating duodenal variceal bleeding, which is a rare and life-threatening complication of portal hypertension. Here we report an exceedingly unusual case in a 9-year-old boy who had developed left-sided portal hypertension after surgical treatment for pancreatoblastoma followed by a duodenal variceal bleeding with massive melena, severe anemia (hemoglobin 4.5 g/dL) and hypovolemic shock. Emergency partial splenic arterial embolization (PSE) provided a reduction of variceal bleeding and improved blood pressure...
June 2015: Clinical Journal of Gastroenterology
Raquel Rainho Espinosa, Raffaella Inchingolo, Severino Matias Alencar, Maria Teresa Rodriguez-Estrada, Inar Alves Castro
The effect of eleven compounds extracted from red propolis on the oxidative stability of a functional emulsion was evaluated. Emulsions prepared with Echium oil as omega 3 (ω-3 FA) source, containing 1.63 g/100mL of α-linolenic acid (ALA), 0.73 g/100 mL of stearidonic acid (SDA) and 0.65 g/100mL of plant sterol esters (PSE) were prepared without or with phenolic compounds (vanillic acid, caffeic acid, trans-cinnamic acid, 2,4-dihydroxycinnamic acid, p-coumaric acid, quercetin, trans-ferulic acid, trans,trans-farnesol, rutin, gallic acid or sinapic acid)...
September 1, 2015: Food Chemistry
Michael Silverstein, Caroline Kistin, Megan Bair-Merritt, Shannon Wiltsey-Stirman, Emily Feinberg, Yaminette Diaz-Linhart, Jenna Sandler, Ning Chen, Howard Cabral
The impact of depression interventions is often attenuated in women who have experienced trauma. We explored whether psychological avoidance could explain this phenomenon. We synthesized two pilot randomized trials of problem-solving education (PSE) among a total of 93 urban mothers. Outcomes included depressive symptoms and perceived stress. Mothers with avoidant coping styles experienced an average 1.25 episodes of moderately severe depressive symptoms over 3 months of follow-up, compared to 0.40 episodes among those with non-avoidant coping (adjusted incident rate ratio [aIRR] 2...
February 2016: Archives of Women's Mental Health
Chisa Kondo, Masanori Atsukawa, Akihito Tsubota, Noritomo Shimada, Hiroshi Abe, Norio Itokawa, Ai Nakagawa, Takeshi Fukuda, Yoko Matsushita, Katsuhisa Nakatsuka, Chiaki Kawamoto, Katsuhiko Iwakiri, Yoshio Aizawa, Choitsu Sakamoto
OBJECTIVE: Pegylated-interferon/ribavirin (peg-IFN/RBV) therapy with a protease inhibitor is the standard therapy for genotype 1b chronic hepatitis C. Despite improving treatment outcomes, patients with thrombocytopenia are often difficult to treat because interferon commonly exacerbates thrombocytopenia. In this study, partial splenic embolization (PSE) was performed in patients with hypersplenism-induced thrombocytopenia to determine the effectiveness of this method as a potential treatment...
2015: Internal Medicine
Masamichi Okada, Masamichi Yasuno, Masayo Kawakami, Arisa Ishihara, Fuyuki Inagaki, Goshi Oda, Yoshiaki Hara, Tetsuya Yokosuka, Sadaaki Shioiri, Toshiko Kobayashi, Shigeru Yamada
A 61 year-old male with rectal cancer underwent anterior resection with D2 lymph node dissection in August 2007. Carcinoembryonic antigen (CEA) level was 5.6 before the operation. Pathological findings were Rs, tub2»>tub1, type 3, pSE, ly1, v2, pN1 (1/23), H0, P0, M0 , pStage IIIA. Adjuvant chemotherapy with tegafur-uracil (UFT) 600 mg/Leucovorin (LV) 75 mg was administered for 1 year. A recurrence at a site of anastomosis developed and lower anterior resection was required in September 2010. CEA level was 5...
November 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Mara Graziele Maciel Silveira, Antônio Carlos Sobral Sousa, Marcos Antônio Almeida Santos, Irlaneide da Silva Tavares, Stephanie Macedo Andrade, Luiza Dantas Melo, Loren Suyane Oliveira de Andrade, Emmanuel Lima Almeida Santos, Joselina Luzia Menezes Oliveira
BACKGROUND: Physical stress echocardiography is an established methodology for diagnosis and risk stratification of coronary artery disease in patients with physical capacity. In obese (body mass index ≥ 30 kg/m2) the usefulness of pharmacological stress echocardiography has been demonstrated; however, has not been reported the use of physical stress echocardiography in this growing population group. OBJECTIVE: To assess the frequency of myocardial ischemia in obese and non-obese patients undergoing physical stress echocardiography and compare their clinical and echocardiographic differences...
May 2015: Arquivos Brasileiros de Cardiologia
Halise Inci Gul, Mehtap Tugrak, Hiroshi Sakagami
In this study, the compounds having acrylophenone structure, 1-aryl-2-(N-methylpiperazinomethyl)-2-propen-1-one dihydrochlorides, were synthesized and their chemical structures were identified with (1)H NMR, (13)C NMR and HRMS spectra. The cytotoxicities of the compounds were tested towards Ca9-22 (human gingival carcinoma), HSC-2 (human oral squamous carcinoma), HSC-3 (human oral squamous carcinoma) and HSC-4 (human oral squamous carcinoma) cell lines as tumor cell lines and HGF (gingival fibroblasts), HPLF (periodontal ligament fibroblasts) and HPC (pulp cells) cell lines as non-tumor cell lines...
2016: Journal of Enzyme Inhibition and Medicinal Chemistry
Haiyun Wu, Yin Wang, Yun Wu, Jing Qiao, Hao Li, Shujuan Zheng, Xiaodong Xia, Shenghui Cui, Xin Wang, Meili Xi, Jianghong Meng, Baowei Yang
β-Lactamases and extended-spectrum β-lactamases (ESBLs) producing pathogenic bacteria were widely studied previously in China, but were seldom focused on foodborne Salmonella. In this study, an investigation concerning β-lactamases and ESBLs producing Salmonella recovered from retail raw chickens was performed. Sixty of 699 foodborne Salmonella isolates were detected as β-lactamases and ESBLs-producing ones that covered 12 Salmonella serotypes and exhibited different pulsed-field gel electrophoresis genotypes...
March 2015: Foodborne Pathogens and Disease
Sara Gasparini, Edoardo Ferlazzo, Ettore Beghi, Vito Sofia, Laura Mumoli, Angelo Labate, Vittoria Cianci, Daniela Fatuzzo, Marina Angela Bellavia, Luciano Arcudi, Emilio Russo, Giovambattista De Sarro, Antonio Gambardella, Umberto Aguglia
OBJECTIVE: To compare anatomo-electro-clinical findings between patients with epilepsy associated with leukoaraiosis only (EAL) and patients with a well-defined vascular lesion, i.e. post-stroke epilepsy (PSE). METHODS: Two hundred eighty-three subjects with epilepsy and cerebrovascular disease, consecutively seen in our epilepsy centres from January 2000 to March 2014, were retrospectively considered. Inclusion criteria were: history of one or more unprovoked seizures and MRI evidence of one or more vascular lesions...
January 2015: Epilepsy Research
J G Pallarés, Á López-Samanes, V E Fernández-Elías, R Aguado-Jiménez, J F Ortega, C Gómez, R Ventura, J Segura, R Mora-Rodríguez
This study analyzed the effects of pseudoephedrine (PSE) provided at different time of day on neuromuscular performance, side effects, and violation of the current doping cut-off threshold [World Anti-Doping Agency (WADA)]. Nine resistance-trained males carried out bench press and full squat exercises against four incremental loads (25%, 50%, 75%, and 90% one repetition maximum [1RM]), in a randomized, double-blind, cross-over design. Participants ingested either 180 mg of PSE (supra-therapeutic dose) or placebo in the morning (7:00 h; AM(PLAC) and AM(PSE)) and in the afternoon (17:00 h; PM(PLAC) and PM(PSE))...
December 2015: Scandinavian Journal of Medicine & Science in Sports
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