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Liver iron

Natasha McDonald, Peter J Eddowes, James Hodson, Scott I K Semple, Nigel P Davies, Catherine J Kelly, Stella Kin, Miranda Phillips, Amy H Herlihy, Timothy J Kendall, Rachel M Brown, Desley A H Neil, Stefan G Hübscher, Gideon M Hirschfield, Jonathan A Fallowfield
LiverMultiScan is an emerging diagnostic tool using multiparametric MRI to quantify liver disease. In a two-centre prospective validation study, 161 consecutive adult patients who had clinically-indicated liver biopsies underwent contemporaneous non-contrast multiparametric MRI at 3.0 tesla (proton density fat fraction (PDFF), T1 and T2* mapping), transient elastography (TE) and Enhanced Liver Fibrosis (ELF) test. Non-invasive liver tests were correlated with gold standard histothological measures. Reproducibility of LiverMultiScan was investigated in 22 healthy volunteers...
June 15, 2018: Scientific Reports
Daniel Stocker, Mustafa R Bashir, Stephan A R Kannengiesser, Cäcilia S Reiner
OBJECTIVE: This study aimed to evaluate the performance of an automated workflow of volumetric liver proton density fat fraction (PDFFvol) and R2* quantification with automated inline liver volume (LV) segmentation. METHODS: Dual-echo and multiecho Dixon magnetic resonance images were evaluated in 74 consecutive patients (group A, PDFF < 10%; B, PDFF ≥ 10%; C, R2* ≥ 100 s; D, post-hemihepatectomy). The values of PDFFvol and R2*vol measurements across the LV were generated on multiecho images in an automated fashion based on inline liver segmentation on dual-echo images...
June 12, 2018: Journal of Computer Assisted Tomography
Changhwan Ahn, Jong-Sam Choi, Eui-Bae Jeung
Transmembrane cation channels include those for calcium, copper and iron ion transport. Each channel has physiological significance, and all have been associated with disease. However, the comparative study of transcriptional‑translational levels in canine organs has not been previously reported. In the present study, organ‑specific expression of calcium channels, including sodium/potassium/calcium exchanger 3 (NCKX3) and transient receptor potential cation channel subfamily V member 2 (TRPV2), copper channels, including high affinity copper uptake protein 1 (CTR1) and copper‑transporting ATPase 1 (ATP7A), and iron channels, including iron‑regulated transporter 1 (IREG1) and hephaestin (HEPH) proteins and their mRNAs were examined in the canine duodenum, kidney, spleen and liver...
June 7, 2018: Molecular Medicine Reports
Jessye Wojtusik, Terri L Roth
  Iron overload disorder (IOD) can lead to organ dysfunction and may exacerbate other diseases in the critically endangered black rhinoceros ( Diceros bicornis). It is important to develop methods for monitoring the progression of iron storage (hemosiderosis), diagnosing the disease, and evaluating treatments in this species. Traditionally, an equine enzyme immunoassay (EIA) was used to measure rhinoceros ferritin, a serum protein correlated to iron stores. The goal of this study was to validate a rhinoceros-specific assay and investigate factors potentially associated with ferritin concentrations in black rhinoceros...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
Teruhisa Higuchi, Mitsuhiko Moriyama, Akiko Fukushima, Hiroshi Matsumura, Shunichi Matsuoka, Tatsuo Kanda, Masahiko Sugitani, Akiko Tsunemi, Takahiro Ueno, Noboru Fukuda
Background: Excess iron is associated with non-alcoholic steatohepatitis (NASH). Results: mRNA expression of duodenal cytochrome b, divalent metal transporter 1, ferroportin 1, hepcidin, hephaestin and transferrin receptor 1 in liver were higher in high fat, high cholesterol-containing diet (HFCD) group than in normal diet (ND) group. mRNA levels of divalent metal transporter 1 and transferrin receptor 1, which stimulate iron absorption and excretion, were enhanced in small intestine...
May 25, 2018: Oncotarget
Fuhua Yan, Naying He, Huimin Lin, Ruokun Li
Iron has long been implicated in many neurological and other organ diseases. It is known that over and above the normal increases in iron with age, in certain diseases there is an excessive iron accumulation in the brain and liver. MRI is a noninvasive means by which to image the various structures in the brain in three dimensions and quantify iron over the volume of the object of interest. The quantification of iron can provide information about the severity of iron-related diseases as well as quantify changes in iron for patient follow-up and treatment monitoring...
June 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Chumei Huang, Yaqing Li, Yubo Guo, Zuoquan Zhang, Guoda Lian, Yinting Chen, Jian Li, Yonghui Su, Jiajia Li, Kege Yang, Shaojie Chen, Hong Su, Kaihong Huang, Linjuan Zeng
The molecular mechanism of perineural invasion (PNI) is unclear, and insufficient detection during early-stage PNI in vivo hampers its investigation. We aimed to identify a cytokine paracrine loop between pancreatic ductal adenocarcinoma (PDAC) cells and nerves and established a noninvasive method to monitor PNI in vivo . Methods: A Matrigel/ dorsal root ganglia (DRG) system was used to observe PNI in vitro , and a murine sciatic nerve invasion model was established to examine PNI in vivo . PNI was assessed by MRI with iron oxide nanoparticle labeling ...
2018: Theranostics
Emmanuel Rineau, Thomas Gaillard, Naïg Gueguen, Vincent Procaccio, Daniel Henrion, Fabrice Prunier, Sigismond Lasocki
BACKGROUND: Iron deficiency (ID), with or without anemia, is frequent in heart failure patients, and iron supplementation improves patient condition. However, the link between ID (independently of anemia) and cardiac function is poorly understood, but could be explained by an impaired mitochondrial metabolism. Our aim was to explore this hypothesis in a mouse model. METHODS AND RESULTS: We developed a mouse model of ID without anemia, using a blood withdrawal followed by 3-weeks low iron diet...
September 1, 2018: International Journal of Cardiology
Yasuaki Tatsumi, Ayako Kato, Koichi Kato, Hisao Hayashi
AIM: Iron and copper are trace elements essential for health, and iron metabolism is tightly regulated by cuproproteins. Clarification of the interactions between iron and copper may provide a better understanding of the pathophysiology and treatment strategy for hemochromatosis, Wilson disease, and related disorders. METHODS: The hepcidin/ferroportin system was used to classify genetic iron overload syndromes in Japan, and ceruloplasmin and ATP7B were introduced for subtyping Wilson disease into the severe hepatic and classical forms...
June 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Laurence Britton, Kim Bridle, Janske Reiling, Nishreen Santrampurwala, Leesa Wockner, Helena Ching, Katherine Stuart, V Nathan Subramaniam, Gary Jeffrey, Tim St Pierre, Michael House, Joel Gummer, Robert Trengove, John Olynyk, Darrell Crawford, Leon Adams
Rodent and cell-culture models support a role for iron-related adipokine dysregulation and insulin resistance in the pathogenesis of nonalcoholic fatty liver disease (NAFLD); however, substantial human data are lacking. We examined the relationship between measures of iron status, adipokines, and insulin resistance in patients with NAFLD in the presence and absence of venesection. This study forms part of the Impact of Iron on Insulin Resistance and Liver Histology in Nonalcoholic Steatohepatitis (IIRON2) study, a prospective randomized controlled trial of venesection for adults with NAFLD...
June 2018: Hepatology Communications
Yutian Pu, Shuhui Li, Haitao Xiong, Xiaofeng Zhang, Yizhen Wang, Huahua Du
Early nutrition is key to promoting gut growth and education of the immune system. Although iron deficiency anemia has long been recognized as a serious iron disorder, the effects of iron supplementation on gut development are less clear. Therefore, using suckling piglets as the model for iron deficiency, we assessed the impacts of iron supplementation on hematological status, gut development, and immunity improvement. Piglets were parenterally supplied with iron dextran (FeDex, 60 mg Fe/kg) by intramuscular administration on the third day after birth and slaughtered at the age of two days, five days, 10 days, and 20 days...
June 5, 2018: Nutrients
Hannah M Atkins, Susan E Appt, Robert N Taylor, Yaritbel Torres-Mendoza, Emily E Lenk, Nancy S Rosenthal, David L Caudell
Endometriosis is characterized by endometrial tissue development outside the uterus. Anemia and iron depletion do notcommonly accompany endometriosis in women, despite chronic abdominal inflammation and heavy menstrual bleeding.The objective of this study was to examine iron kinetics associated with endometriosis by using a NHP model, to betterunderstand the underlying mechanism of abnormal hematogram values in women with endometriosis. Hematologic datafrom 46 macaques with endometriosis were examined for signs of iron depletion...
June 5, 2018: Comparative Medicine
Joel Marmur, Soheir Beshara, Gösta Eggertsen, Liselotte Onelöv, Nils Albiin, Olof Danielsson, Rolf Hultcrantz, Per Stål
BACKGROUND: One-third of patients with non-alcoholic fatty liver disease (NAFLD) develop dysmetabolic iron overload syndrome (DIOS), the pathogenesis of which is unknown. Altered production of the iron-regulatory peptide hepcidin has been reported in NAFLD, but it is unclear if this is related to iron accumulation, lipid status or steatohepatitis. METHODS: Eighty-four patients with liver disease, 54 of which had iron overload, underwent liver biopsy (n = 66) and/or magnetic resonance imaging (n = 35) for liver iron content determination...
June 5, 2018: BMC Gastroenterology
Jiayou Wang, Noah Kainrad, Hong Shen, Zhou Zhou, Paula Rote, Yanqiao Zhang, Laura E Nagy, Jiashin Wu, Min You
Aberrant pre-mRNA splicing plays a pivotal role in liver diseases. However, roles of splicing regulators in alcoholic liver disease are unknown. Here, we investigated a splicing regulator Slu7 in the development of alcoholic steatohepatitis. Adenovirus (Ad)-mediated alteration of hepatic Slu7 expression in mice pair-fed either with or without (as control) ethanol in their diet was utilized. Knockdown of hepatic Slu7 by Ad-Slu7shRNA treatment ameliorated inflammation and attenuated liver injury in mice after ethanol administration...
June 2, 2018: American Journal of Pathology
Wejdan Al-Shakarchi, Ali Alsuraifi, Anthony Curtis, Clare Hoskins
Liver cancer treatments are often hindered by poor drug physicochemical properties, hence there is a need for improvement in order to increase patient survival and outlook. Combination therapies have been studied in order to evaluate whether increased overall efficacy can be achieved. This study reports the combined treatment of liver cancer cells with a combination treatment of chemotherapeutic agent paclitaxel and pro-apoptotic protein cytochrome C. In order to administer both agents in a single formulation, a poly(allylamine)-based amphiphile has been fabricated with the incorporation of a hybrid iron oxide-gold nanoparticle into its structure...
May 26, 2018: Pharmaceutics
Joe Varghese, Jithu James, Sophie Vaulont, Andrew Mckie, Molly Jacob
BACKGROUND: An iron-overloaded state has been reported to be associated with insulin resistance. On the other hand, conditions such as classical hemochromatosis (where iron overload occurs primarily in the liver) have been reported to be associated with increased insulin sensitivity. The reasons for these contradictory findings are unclear. In this context, the effects of increased intracellular iron per se on insulin signaling in hepatocytes are not known. METHODS: Mouse primary hepatocytes were loaded with iron in vitro by incubation with ferric ammonium citrate (FAC)...
May 31, 2018: Biochimica et Biophysica Acta
Deepali Mohanty, Luna Samanta
Iron though an essential cofactor for many proteins including haemoglobin and cytochromes, when in excess (>1 ppm in water and 100 ppm in fish tissue) elicits toxicity via Fenton reaction inducing oxidative stress. The present study aimed to evaluate the efficacy of dietary Spirulina (Arthrospira platensis) supplementation on waterborne-iron induced oxidative stress in the tissues of Notopterus notopterus. Juvenile fishes were divided randomly into 4 groups, namely, Group-I: control fed with commercial diet only, Group-II, III and IV treated with 0...
May 22, 2018: Environmental Toxicology and Pharmacology
M B Reddy, Seth M Armah
BACKGROUND: Iron deficiency is a leading global nutritional problem. Ferrous sulfate (FeSO4) is the most common iron source used for supplementation. Because of many side effects associated with its consumption, it is important to identify new forms of iron. OBJECTIVES: To assess the bioavailability of iron-enriched Aspergillus oryzae, Aspiron® (ASP), evaluate the toxicity of high-dose iron supplementation with ASP; and determine ASP impact on gut microbiota in rats...
May 31, 2018: Journal of Agricultural and Food Chemistry
Muddasir Hassan Abbasi, Sana Fatima, Muhammad Babar Khawar, Shah Jahan, Nadeem Sheikh
This study was aimed to find histological changes in the extrahepatic organs, hepatic iron deposition, and gene expression of some iron regulatory proteins in rats after sterile muscle abscess during the acute intoxication of Nerium oleander leaves decoction. 10 ml/kg of the leaves extract was injected intramuscularly in Wistar rats (200-225 g, n = 4). Control animals received saline injection of matched volume. Animals were anesthetized and sacrificed after 3, 6, 12, and 24 h after administration of decoction...
2018: Canadian Journal of Gastroenterology & Hepatology
MaFeng Liu, Mi Huang, Yun Shui, Francis Biville, DeKang Zhu, MingShu Wang, RenYong Jia, Shun Chen, KunFeng Sun, XinXin Zhao, Qiao Yang, Ying Wu, XiaoYue Chen, AnChun Cheng
Iron is one of the most important elements for bacterial survival and pathogenicity. The iron uptake mechanism of Riemerella anatipestifer (R. anatipestifer, RA), a major pathogen that causes septicemia and polyserositis in ducks, is largely unknown. Here, the functions of the putative TonB-dependent iron transporter of RA-CH-1, B739_1343, in iron utilization and pathogenicity were investigated. Under iron-starved conditions, the mutant strain RA-CH-1ΔB739_1343 exhibited more seriously impaired growth than the wild-type strain RA-CH-1, and the expression of B739_1343 in the mutant strain restored growth...
2018: PloS One
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