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Liver iron

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https://www.readbyqxmd.com/read/29032072/oxidative-stress-prediction-a-preliminary-approach-using-a-response-surface-based-technique
#1
M Sierra, L Bragg-Gonzalo, J Grasa, M J Muñoz, D González, F J Miana-Mena
A response surface was built to predict the lipid peroxidation level, generated in an iron-ascorbate in vitro model, of any organ, which is correlated with the oxidative stress injury in biological membranes. Oxidative stress studies are numerous, usually performed on laboratory animals. However, ethical concerns require validated methods to reduce the use of laboratory animals. The response surface described here is a validated method to replace animals. Tissue samples of rabbit liver, kidney, heart, skeletal muscle and brain were oxidized with different concentrations of FeCl3 (0...
October 12, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29027371/differential-proteomic-analysis-of-dimethylnitrosamine-dmn-induced-liver-fibrosis
#2
Xiujie Liu, Rongji Dai, Ming Ke, Imran Suheryani, Weiwei Meng, Yulin Deng
Liver fibrosis is a common pathological feature of many chronic liver diseases. To characterize the entire panorama of proteome changes in DMN-induced liver fibrosis, iTRAQ-based differential proteomic analysis was performed with DMN-induced liver fibrosis rats. A total of 4155 confidently identified proteins were found, with 365 proteins showing significant changes (fold changes of >1.5 or < 0.67, P < 0.05). In metabolic activation, proteins assigned to drug metabolism enzymes (e.g., CYP2D1) changed, suggesting that the liver protection mechanism was activated to relieve DMN toxicity...
October 13, 2017: Proteomics
https://www.readbyqxmd.com/read/29026901/dietary-iron-loading-negatively-affects-liver-mitochondrial-function
#3
Chiara Volani, Carolina Doerrier, Egon Demetz, David Haschka, Giuseppe Paglia, Alexandros A Lavdas, Erich Gnaiger, Guenter Weiss
Iron is an essential co-factor for several metabolic processes, including mitochondrial respiration, and mitochondria are the major sites of iron-utilization. Cellular iron homeostasis must be tightly regulated, as intracellular iron deficiency can lead to insufficient energy production, whereas iron overload triggers ROS (reactive oxygen species) formation via the Fenton reaction. So far little is known on how iron imbalances affect mitochondrial function in vivo and the impact of the genotype on that, we studied the effects of dietary iron loading on mitochondrial respiratory capacity in liver by comparing two genetically divergent mouse strains, namely C57BL/6N and FVB mice...
October 13, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29021231/deletion-of-bmp6-worsens-the-phenotype-of-hjv-deficient-mice-and-attenuates-hepcidin-levels-reached-after-lps-challenge
#4
Chloé Latour, Céline Besson-Fournier, Ophélie Gourbeyre, Delphine Meynard, Marie-Paule Roth, Hélène Coppin
Lack of either BMP6 or the BMP co-receptor hemojuvelin (HJV) in mice leads to a similar phenotype with hepcidin insufficiency, hepatic iron loading, and extrahepatic iron accumulation in males. This is consistent with the current views that HJV is a co-receptor for BMP6 in hepatocytes. To determine whether BMP6 and HJV may also signal to hepcidin independently of each other, we intercrossed Hjv(-/-) and Bmp6(-/-) mice and compared the phenotype of animals of the F2 progeny. Loss of Bmp6 further repressed Smad signaling and hepcidin expression in the liver of Hjv(-/-) mice of both genders, and led to iron accumulation in the pancreas and the heart of females...
October 11, 2017: Blood
https://www.readbyqxmd.com/read/29017023/maternal-iron-nutriture-as-a-critical-modulator-of-fasd-risk-in-alcohol-exposed-pregnancies
#5
Kaylee K Helfrich, Nipun Saini, Pamela J Kling, Susan M Smith
Alcohol consumption during pregnancy places the fetus at risk for permanent physical, cognitive, and behavioral impairments, collectively termed fetal alcohol spectrum disorders (FASD). However, prenatal alcohol exposure (PAE) outcomes vary widely, and growing evidence suggests that maternal nutrition is a modifying factor. Certain nutrients, such as iron, may modulate FASD outcomes. Untreated gestational iron deficiency (ID) causes persistent neurodevelopmental deficits in the offspring that affect many of the same domains damaged by PAE...
October 10, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28994539/-siwu-decoction-improves-iron-deficiency-anemia-in-infant-rats-and-regulates-iron-metabolism
#6
Ran He, Hong-Jin Wang, Ying Zhou, Jing-Jing Li, Xiao-Yu Xu
To investigate the effect of Siwu decoction on improving iron deficiency anemia in infant rats and observe its regulatory effects on iron metabolism. SD rats were fed with low iron fodder for 2 weeks, and then the rats with hemoglobin level less than 75 g•L ⁻¹ were screened out and randomly divided into model group, Ferrous succinate 50 mg•kg ⁻¹ group, Siwu decoction 4 g•kg ⁻¹, 8 g•kg ⁻¹ and 16 g•kg ⁻¹ groups. After 4 weeks' gavage administration, Wright-Giemsa's staining of blood smear and HE staining of the livers were conducted, and all rats were tested for blood routine, serum iron, total iron binding capacity, serum ferritin, serum hepcidin and liver hepcidin...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28986474/digging-deeper-into-cyp3a-testosterone-metabolism-kinetic-regio-and-stereoselectivity-differences-between-cyp3a4-5-and-cyp3a7
#7
Sylvie E Kandel, Lyrialle W Han, Qingcheng Mao, Jed N Lampe
The metabolism of testosterone to 6β-hydroxytestosterone is a commonly used assay to evaluate human CYP3A enzyme activities. However, previous reports have indicated that CYP3A7 also produces 2α-hydroxytestosterone, and that a 2α-hydroxytestosterone:6β-hydroxytestosterone ratio may be a unique biomarker of the isozyme's activity. Until now, the full metabolite and kinetic profile for testosterone hydroxylation by CYP3A7 has not been fully examined. To this end, we performed a complete kinetic analysis of the 6β-hydroxytestosterone, 2α-hydroxytestosterone and 2β-hydroxytestosterone metabolites for recombinant SupersomeTM CYP3A4, 3A5, and 3A7 enzymes and monitored metabolism in fetal and adult human liver microsomes for comparison...
October 6, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28985135/whole-body-diffusion-weighted-mr-imaging-of-iron-deposits-in-hodgkin-follicular-and-diffuse-large-b-cell-lymphoma
#8
Anne-Ségolène Cottereau, Sébastien Mulé, Chieh Lin, Karim Belhadj, Alexandre Vignaud, Christiane Copie-Bergman, Alice Boyez, Pierre Zerbib, Vania Tacher, Elodie Scherman, Corinne Haioun, Alain Luciani, Emmanuel Itti, Alain Rahmouni
Purpose To analyze the frequency and distribution of low-signal-intensity regions (LSIRs) in lymphoma lesions and to compare these to fluorodeoxyglucose (FDG) uptake and biologic markers of inflammation. Materials and Methods The authors analyzed 61 untreated patients with a bulky lymphoma (at least one tumor mass ≥7 cm in diameter). When a LSIR within tumor lesions was detected on diffusion-weighted images obtained with a b value of 50 sec/mm(2), a T2-weighted gradient-echo (GRE) sequence was performed and calcifications were searched for with computed tomography (CT)...
October 6, 2017: Radiology
https://www.readbyqxmd.com/read/28983468/increased-plasmodium-falciparum-parasitemia-in-non-splenectomized-saimiri-sciureus-monkeys-treated-with-clodronate-liposomes
#9
Janaiara A Cunha, Leonardo J M Carvalho, Cesare Bianco-Junior, Márcia C R Andrade, Lilian R Pratt-Riccio, Evelyn K P Riccio, Marcelo Pelajo-Machado, Igor J da Silva, Pierre Druilhe, Cláudio Tadeu Daniel-Ribeiro
A major constraint in the study of Plasmodium falciparum malaria, including vaccine development, lies on the parasite's strict human host specificity and therefore the shortage of animal experimental models able to harbor human plasmodia. The best experimental models are neo-tropical primates of the genus Saimiri and Aotus, but they require splenectomy to reduce innate defenses for achieving high and consistent parasitemias, an important limitation. Clodronate-liposomes (CL) have been successfully used to deplete monocytes/macrophages in several experimental models...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28978826/progress-in-iron-metabolism-research
#10
Hiroshi Kawabata
Iron is essential for various cellular processes, but an excess of iron may cause organ damage through the production of reactive oxygen species. Therefore, the amount of iron in the body must be strictly controlled. The central regulator of systemic iron homeostasis is hepcidin, which is primarily produced in the liver. Various molecules, including HFE, transferrin receptor 2 (TFR2), and hemojuvelin (HJV), are involved in sensing systemic iron status. Hepatocytes produce hepcidin in response to excess iron and inflammatory stimuli (e...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28974951/nutritional-immunity-triggers-the-modulation-of-iron-metabolism-genes-in-the-sub-antarctic-notothenioid-eleginops-maclovinus-in-response-to-piscirickettsia-salmonis
#11
Danixa Martínez, Ricardo Oyarzún, Juan Pablo Pontigo, Alex Romero, Alejandro J Yáñez, Luis Vargas-Chacoff
Iron deprivation is a nutritional immunity mechanism through which fish can limit the amount of iron available to invading bacteria. The aim of this study was to evaluate the modulation of iron metabolism genes in the liver and brain of sub-Antarctic notothenioid Eleginops maclovinus challenged with Piscirickettsia salmonis. The specimens were inoculated with two P. salmonis strains: LF-89 (ATCC(®) VR-1361™) and Austral-005 (antibiotic resistant). Hepatic and brain samples were collected at intervals over a period of 35 days...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28973651/iron-rich-diet-decreases-mycobacterial-burden-and-correlates-with-hepcidin-upregulation-lower-pro-inflammatory-mediators-and-higher-t-cell-recruitment-in-a-model-of-m-bovis-bcg-infection
#12
Rafiou Agoro, Sulayman Benmerzoug, Stéphanie Rose, Mélanie Bouyer, Raffaella Gozzelino, Irene Garcia, Bernhard Ryffel, Valerie F J Quesniaux, Catherine Mura
Background: Recent evidence indicates a robust competition between host and mycobacteria for iron acquisition during infection. Variable consequences of iron supplementation have been reported on the susceptibility to mycobacterial infection. In this study, we revisited the effects of experimental iron-enriched diet on Mycobacterium bovis BCG infection. Methods: Mice fed with standard diet or diet moderately enriched with iron were infected with M. bovis BCG-GFP...
August 2, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28971671/self-assembly-of-monodisperse-carbon-dots-into-high-brightness-nanoaggregates-for-cellular-uptake-imaging-and-iron-iii-sensing
#13
Tzu-Heng Chen, Wei-Lung Tseng
This study describes a bottom-up assembly route for monodisperse carbon dots (CDs) into different sizes of CD aggregates through the control of the concentration of fatty acids. The highly monodisperse CDs were prepared via solvent-thermal treatment of edible soybean oil, which generated glycerol-based polymer as a carbon source and fatty acid as a surface capping in the synthetic process. The as-synthesized CDs exhibited small particle size variation (2.7 ± 0.2 nm) and narrow emission bands (full width at half-maximum <20 nm)...
October 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28971221/uncoupled-iron-homeostasis-in-type-2-diabetes-mellitus
#14
Sandro Altamura, Stefan Kopf, Julia Schmidt, Katja Müdder, Ana Rita da Silva, Peter Nawroth, Martina U Muckenthaler
Diabetes mellitus is frequently associated with iron overload conditions, such as primary and secondary hemochromatosis. Conversely, patients affected by type 2 diabetes mellitus (T2DM) show elevated ferritin levels, a biomarker for increased body iron stores. Despite these documented associations between dysregulated iron metabolism and T2DM, the underlying mechanisms are poorly understood. Here, we show that T2DM patients have reduced serum levels of hepcidin, the iron-regulated hormone that maintains systemic iron homeostasis...
October 3, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28970716/autoimmune-hepatitis-diagnostic-dilemma-when-it-is-disguised-as-iron-overload-syndrome
#15
Gyanendra K Acharya, Hung-I Liao, Simona Frunza-Stefan, Ronakkumar Patel, Moe Khaing
Elevated serum ferritin level is a common finding in iron overload syndrome, autoimmune and viral hepatitis, alcoholic and nonalcoholic fatty liver diseases. High transferrin saturation is not a common finding in above diseases except for iron overload syndrome. We encountered a challenging case of 73-year-old female who presented with yellowish discoloration of skin, dark color urine and dull abdominal pain. Initial laboratory tests reported mild anemia; elevated bilirubin, liver enzymes, and transferrin saturation...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28970702/generic-direct-acting-antivirals-in-treatment-of-chronic-hepatitis-c-infection-in-patients-of-thalassemia-major
#16
Aabha Nagral, Smita Sawant, Nishtha Nagral, Pathik Parikh, Priya Malde, Rashid Merchant
BACKGROUND: There is no published data of treating hepatitis C in thalassemia major patients with any sofosbuvir based direct acting antivirals (DAAs). This study was performed to determine the efficacy and safety of these regimes using generic drugs in the thalassemia major population. METHODS: In this observational study, 902 patients of thalassemia major from five transfusion centres in Mumbai were screened for HCV antibody. Of the 120 positive patients, HCV RNA was detected in 50%...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28968980/safety-and-tolerability-of-deferasirox-in-pediatric-hematopoietic-stem-cell-transplant-recipients-one-facility-s-five-years-experience-of-chelation-treatment
#17
Natalia Maximova, Massimo Gregori, Roberto Simeone, Aurelio Sonzogni, Giulia Boz, Carmen Fucile, Valeria Marini, Antonietta Martelli, Francesca Mattioli
42 pediatric patients with iron overload, who underwent liver biopsy and DFX treatment after hematopoietic stem cell transplantation were included in the study group. The patients were divided into two groups diversified according to deferasirox trough plasma concentrations (DFX Ctrough) with cut-off equal to10 mcg/mL. The average dose of DFX was 25.9 mg/kg in the DFX Ctrough < 10 mcg/mL group versus 19.2 mg/kg in the DFX Ctrough > 10 mcg/mL group (p=0,0003). The mean duration of DFX treatment was 135...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28968930/protective-potential-of-parrotiopsis-jacquemontiana-decne-rehder-on-carbon-tetrachloride-induced-hepatotoxicity-in-experimental-rats
#18
Saima Ali, Muhammad Rashid Khan, Moniba Sajid
The current study aimed at exploring hepatoprotective potential of Parrotiopsis jacquemontiana leaves methanol extract (PJM) in rat. PJM constituted of significant amount of total phenolic and total flavonoid content. PJM and ethyl acetate fraction (PJE) exhibited strong antioxidant potential (DPPH, hydroxyl ion, nitric oxide, iron chelating, β-carotene, reducing power and phosphomolybdate assay) in comparison to other extracts. CCl4 toxicity displayed significant (p<0.05) increase in level of TBARS, H2O2, nitrite while a decrease in SOD, CAT, POD and GSH in liver samples of CCl4 treated group...
September 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28965608/-67-ga-as-a-biosensor-of-iron-needs-in-different-organs-study-performed-on-male-and-female-rats-subjected-to-iron-deficiency-and-exercise
#19
Patricia Vieyra-Reyes, Rigoberto Oros-Pantoja, Eugenio Torres-García, Agustín Gutiérrez-Ruiz, Jonathan Pérez-Honorato
The aim of the present study was to determine the iron needs in different organs and tissues using (67)Ga as a biosensor in males and females rats subjected to iron deficiency (ID) and voluntary exercise (EX). (67)Ga citrate was injected i.p. to female and male Wistar rats (n=5/sex/group). Groups: Control (sedentary conditions), Control+EX, ID and ID+EX. To determine the (67)Ga uptake, samples from the following regions of interest (ROIs) were extracted 12h post-injection: blood, liver, gonads, bone marrow, heart, adrenal glands, skeletal muscle, stomach, kidney, eyeball, sciatic nerve, small intestine and peritoneum...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28965585/spatial-investigation-of-the-elemental-distribution-in-wilson-s-disease-liver-after-d-penicillamine-treatment-by-la-icp-ms
#20
Oliver Hachmöller, Andree Zibert, Hans Zischka, Michael Sperling, Sara Reinartz Groba, Inga Grünewald, Eva Wardelmann, Hartmut H-J Schmidt, Uwe Karst
At present, the copper chelator d-penicillamine (DPA) is the first-line therapy of Wilson's disease (WD), which is characterized by an excessive copper overload. Lifelong DPA treatments aim to reduce the amount of detrimental excess copper retention in the liver and other organs. Although DPA shows beneficial effect in many patients, it may cause severe adverse effects. Despite several years of copper chelation therapy, discontinuation of DPA therapy can be linked to a rapidly progressing liver failure, indicating a high residual liver copper load...
December 2017: Journal of Trace Elements in Medicine and Biology
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