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Liver iron

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https://www.readbyqxmd.com/read/29684610/fishmeal-replacement-by-rice-protein-concentrate-with-xylooligosaccharides-supplement-benefits-the-growth-performance-antioxidant-capability-and-immune-responses-against-aeromonas-hydrophila-in-blunt-snout-bream-megalobrama-amblycephala
#1
Kenneth Prudence Abasubong, Wen-Bin Liu, Ding-Dong Zhang, Xiang-Yang Yuan, Si-Lei Xia, Chao Xu, Xiang-Fei Li
This study aimed to investigate the effects of fishmeal (FM) replacement by rice protein concentrate (RPC) with a xylooligosaccharides supplement on the growth performance, antioxidant capability and immune response against Aeromonas hydrophila in blunt snout bream (Megalobrama amblycephala). Fish (46.85 ± 0.34 g) were randomly assigned to one of 6 diets, namely the control diet (containing FM), the RPC diet (FM replaced by RPC) and RPC diet supplemented with 0.5, 1.5, 2.3 and 3% XOS respectively, for 8 weeks...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29680674/multifunctional-hybrid-nanoconstruct-of-zerovalent-iron-and-carbon-dots-for-magnetic-resonance-angiography-and-optical-imaging-an-in-vivo-study
#2
N Nimi, Ariya Saraswathy, Shaiju S Nazeer, Nimmi Francis, Sachin J Shenoy, Ramapurath S Jayasree
In magnetic resonance imaging (MRI), gadolinium (Gd) complexes are very often used as contrast agents to enhance the signal from soft tissue deformities and vascular anomalies, to improve the accuracy of diagnosis. The safety concern of using Gd complexes in renally compromised patients pose limitations on its application. To overcome this scenario, we introduce a nontoxic zerovalent iron based nanoparticle as a novel contrast agent for MR angiography and a hybrid version of the same to serve as a dual function contrast agent for targeted liver imaging...
April 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29675354/quantification-of-liver-iron-concentration-using-the-apparent-susceptibility-of-hepatic-vessels
#3
Saifeng Liu, Chaoyue Wang, Xiaoqi Zhang, Panli Zuo, Jiani Hu, E Mark Haacke, Hongyan Ni
Background: The quantification of liver iron concentration (LIC) is important for the monitoring of the body iron level in patients with iron overload. Conventionally, LIC is quantified through R2 or R2* mapping using MRI. In this paper, we demonstrate an alternative approach for LIC quantification through measuring the apparent susceptibility of hepatic vessels using quantitative susceptibility mapping (QSM). Methods: QSM was performed in the liver region with the iterative susceptibility weighted imaging and mapping (iSWIM) algorithm, using the geometry of the vessels extracted from magnitude images as constraints...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29675353/magnetic-particle-imaging-of-islet-transplantation-in-the-liver-and-under-the-kidney-capsule-in-mouse-models
#4
Ping Wang, Patrick W Goodwill, Prachi Pandit, Jeff Gaudet, Alana Ross, Junfeng Wang, Elaine Yu, Daniel W Hensley, Timothy C Doyle, Christopher H Contag, Steven Conolly, Anna Moore
Background: Islet transplantation (Tx) represents the most promising therapy to restore normoglycemia in type 1 diabetes (T1D) patients to date. As significant islet loss has been observed after the procedure, there is an urgent need for developing strategies for monitoring transplanted islet grafts. In this report we describe for the first time the application of magnetic particle imaging (MPI) for monitoring transplanted islets in the liver and under the kidney capsule in experimental animals...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29672865/dietary-iron-fortification-normalizes-fetal-hematology-hepcidin-and-iron-distribution-in-a-rat-model-of-prenatal-alcohol-exposure
#5
Shane M Huebner, Kaylee K Helfrich, Nipun Saini, Sharon E Blohowiak, Adrienne A Cheng, Pamela J Kling, Susan M Smith
BACKGROUND: Prenatal alcohol exposure (PAE) causes neurodevelopmental disability. Clinical and animal studies show gestational iron deficiency exacerbates PAE's behavioral and growth deficits. In rat, PAE manifests an inability to establish iron homeostasis, increasing hepcidin (maternal and fetal) and fetal liver iron while decreasing brain iron and promoting anemia. Here, we hypothesize dietary iron fortification during pregnancy may mitigate alcohol's disruption of fetal iron homeostasis...
April 19, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29669498/an-indian-desert-shrub-hiran-chabba-farsetia-hamiltonii-royle-exhibits-potent-antioxidant-and-hepatoprotective-effect-against-iron-overload-induced-liver-toxicity-in-swiss-albino-mice
#6
Tapasree Basu, Bipul Kumar, Anil Khushalrao Shendge, Sourav Panja, Heerak Chugh, Hemant K Gautam, Nripendranath Mandal
BACKGROUND: Farsetia hamiltonii Royle, also known as Hiran Chabba grows in desert regions. It is widely used as folk medicine to treat joint pains, diarrhea and diabetes. However, its antioxidant and iron chelation abilities both in vitro and in vivo have not yet been investigated. METHODS: The 70% methanolic extract of F.hamiltonii (FHME) was investigated for its free radical scavenging and iron chelation potential, in vitro. An iron-overload situation was established by intraperitoneal injection of iron-dextran in Swiss albino mice, followed by oral administration of FHME...
April 18, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29668551/fetal-onset-congenital-dyserythropoietic-anemia-type-1-due-to-a-novel-mutation-with-severe-iron-overload-and-severe-cholestatic-liver-disease
#7
Hui-Lin Chin, Le Ye Lee, Pei Lin Koh
We report a rare case of severe congenital dyserythropoietic anemia type 1 with fetal onset. Our patient presented with fetal hydrops from 19 weeks of gestation, requiring multiple intrauterine transfusions. At birth, she had severe hemolytic anemia with severe jaundice, and was subsequently transfusion dependent. She eventually developed severe iron overload and fulminant liver failure before her demise at 5 months of age. Genetic testing revealed a novel mutation in CDAN1.
April 17, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29665075/the-characteristics-of-transferrin-variants-by-carbohydrate-deficient-transferrin-tests-using-capillary-zone-electrophoresis
#8
Gilsung Yoo, Juwon Kim, Kap Joon Yoon, Jong-Han Lee
BACKGROUND: Transferrin is the major plasma transport protein for iron. We aimed to investigate the characteristics of transferrin variant by carbohydrate-deficient transferrin (CDT) test using capillary zone electrophoresis. METHODS: We retrospectively analyzed the CDT tests of 2449 patients from March 2009 to May 2017 at a tertiary hospital in Korea. CDT was quantified using a Capillarys 2 system (Sebia, Lisses, France) by capillary zone electrophoresis. The characteristics of variant transferrin patterns using electropherogram of CDT tests were analyzed...
April 17, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29663858/assessment-of-liver-and-cardiac-iron-overload-using-mri-in-patients-with-chronic-anemias-in-latin-american-countries-results-from-asimila-study
#9
Rodolfo Cancado, Nora P Watman, Clarisse Lobo, Zulay Chona, Fernando Manzur, Fabiola Traina, Miriam Park, Guillermo Drelichman, Juan Pablo Zarate, Luis Marfil
OBJECTIVES: A multicenter, noninterventional, observational study was conducted in the Latin American countries including Argentina, Brazil, Colombia, Mexico, and Venezuela to assess the prevalence of liver and cardiac iron overload using magnetic resonance imaging (MRI) in patients with chronic anemias except thalassemia. METHODS: Patients aged >10 years with transfusion-dependent anemias, except thalassemia, either with <20 units of red blood cell (RBC) transfusions with serum ferritin (SF) levels >2000 ng/mL or with ≥20 units of RBC transfusions regardless of SF level in their lifetime, were enrolled...
April 17, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29663188/magnetic-resonance-imaging-during-management-of-patients-with-transfusion-dependent-thalassemia-a-single-center-experience
#10
Zeynep Karakas, Yasin Yilmaz, Zuhal Bayramoglu, Serap Karaman, Selime Aydogdu, Ayse Ozkan Karagenc, Deniz Tugcu, Memduh Dursun
BACKGROUND: Cardiac and hepatic magnetic resonance imaging evaluation during treatment can tailor physicians' chelation therapy titrations. AIM: The aim of the study was to assess the relationship of cardiac and hepatic T2* values with chelation therapy in patients with transfusion-dependent thalassemia (TDT). METHODS: A total of 106 patients with TDT who were followed up in Istanbul Medical Faculty Thalassemia Center were evaluated for the study...
April 16, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29660923/haemochromatosis-pathophysiology-and-the-red-blood-cell1
#11
Kieran J Richardson, Antony P McNamee, Michael J Simmonds
Haemochromatosis remains the most prevalent genetic disorder of Caucasian populations in Australia and the United States, occurring in ∼1 of 200 individuals and having a carrier frequency of 10-14%. Hereditary haemochromatosis is an autosomal recessive condition, that is phenotypically characterised by a gradual accumulation of iron, above and beyond that required for biological function. Once the binding capacity of iron carriers reaches saturation, the highly reactive free iron generates radicals that may lead to widespread cellular dysfunction...
April 7, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29657410/the-effect-of-purified-quercus-cortex-extract-on-biochemical-parameters-of-organism-and-productivity-of-healthy-broiler-chickens
#12
Galimzhan Kalihanovich Duskaev, Nadezhda Mihajlovna Kazachkova, Alexander Sergeevich Ushakov, Baer Serekpaevich Nurzhanov, Albert Farhitdinovich Rysaev
Aim: Modern methods of producing poultry meat without the use of antibiotics are known, and it is possible to achieve the desired conditions, including the use of herbal preparations. In addition, it is known that metabolites of medicinal plants are inhibitors of the quorum sensing system in bacteria. The aim of the present study was to determine the effect of Quercus cortex extract in a reduced dose on the productivity and body state of healthy chicken broilers. Materials and Methods: For the experiment, 120 heads of 7-day-old healthy broiler chickens were selected, and they were divided into four groups (n=30, 3 replicates of 10 birds in each group) by the analog method...
February 2018: Veterinary World
https://www.readbyqxmd.com/read/29656314/-174-g-c-il-6-polymorphism-and-primary-iron-overload-in-male-patients
#13
Walter F Tetzlaff, Tomás Meroño, Eliana E Botta, Maximiliano E Martín, Patricia B Sorroche, Laura E Boero, Marcelo Castro, Gustavo D Frechtel, Jorge Rey, Jorge Daruich, Gloria E Cerrone, Fernando Brites
Primary iron overload (IO) is commonly associated with mutations in the hereditary hemochromatosis gene (HFE). Nonetheless, other genetic variants may influence the development of IO beyond HFE mutations. There is a single nucleotide polymorphism (SNP) at - 174 G>C of the interleukin (IL)-6 gene which might be associated with primary IO. Our aim was to study the association between the SNP - 174 G>C gene promoter of IL-6 and primary IO in middle-aged male patients. We studied 37 men with primary IO diagnosed by liver histology...
April 14, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29653288/ph-protective-y-1-receptor-ligand-functionalized-antiphagocytosis-bplp-wpu-micelles-for-enhanced-tumor-imaging-and-therapy-with-prolonged-survival-time
#14
Zhenqi Jiang, Yuchen Tian, Dingying Shan, Yinjie Wang, Ethan Gerhard, Jianbi Xia, Rong Huang, Yan He, Aiguo Li, Jianchao Tang, Huimin Ruan, Yong Li, Juan Li, Jian Yang, Aiguo Wu
Nanoparticle-based tumor therapies are extensively studied; however, few are capable of improving patient survival time due to premature drug leakage, off target effects, and poor tissue penetration. Previously, we successfully synthesized a novel family of Y1 receptor (Y1 R) ligand modified, photoluminescent BPLP nanobubbles and nanoparticles for targeted breast cancer ultrasound imaging; however, increased accumulation could also be observed in the liver, kidney, and spleen, suggesting significant interaction of the particles with macrophages in vivo...
April 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29649145/combined-effect-of-anticancer-agents-and-cytochrome-c-decorated-hybrid-nanoparticles-for-liver-cancer-therapy
#15
Wejdan Al-Shakarchi, Ali Alsuraifi, Mohammed Abed, Marwan Abdullah, Alan Richardson, Anthony Curtis, Clare Hoskins
Hepatocellular carcinoma is an aggressive form of liver cancer that displays minimal symptoms until its late stages. Unfortunately, patient prognosis still remains poor with only 10% of patients surviving more than five years after diagnosis. Current chemotherapies alone are not offering efficient treatment, hence alternative therapeutic approaches are urgently required. In this work, we highlight the potential of combination of treatment of hepatocellular carcinoma with existing chemotherapies in combination with pro-apoptotic factor cytochrome C...
April 12, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29644058/porphyria-and-kidney-diseases
#16
Nicolas Pallet, Alexandre Karras, Eric Thervet, Laurent Gouya, Zoubida Karim, Hervé Puy
The kidneys, after the bone marrow and liver, are third in terms of the amounts of haem synthesized daily. Haem is incorporated into haemoproteins that are critical to renal physiology. In turn, disturbances in haem metabolism interfere with renal physiology and are tightly interrelated with kidney diseases. Acute intermittent porphyria causes kidney injury, whereas medical situations associated with end-stage renal disease, such as porphyrin accumulation, iron overload and hepatitis C, participate in the inhibition of uroporphyrinogen decarboxylase and predispose the individual to porphyria cutanea tarda...
April 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29642600/erratum-long-term-dexamethasone-exposure-down-regulates-hepatic-tfr1-and-reduces-liver-iron-concentration-in-rats-nutrients-2017-9-617
#17
(no author information available yet)
The Editorial Office of Nutrients would like to report an error in the published paper [1] [...].
April 10, 2018: Nutrients
https://www.readbyqxmd.com/read/29628397/enhanced-labile-plasma-iron-and-outcome-in-acute-myeloid-leukaemia-and-myelodysplastic-syndrome-after-allogeneic-haemopoietic-cell-transplantation-allive-a-prospective-multicentre-observational-trial
#18
Martin Wermke, Julia Eckoldt, Katharina S Götze, Stefan A Klein, Gesine Bug, Liesbeth C de Wreede, Michael Kramer, Friedrich Stölzel, Malte von Bonin, Johannes Schetelig, Michael Laniado, Verena Plodeck, Wolf-Karsten Hofmann, Gerhard Ehninger, Martin Bornhäuser, Dominik Wolf, Igor Theurl, Uwe Platzbecker
BACKGROUND: The effect of systemic iron overload on outcomes after allogeneic haemopoietic cell transplantation (HCT) has been a matter of substantial debate. We aimed to investigate the predictive value of both stored (MRI-derived liver iron content) and biologically active iron (enhanced labile plasma iron; eLPI) on post-transplantation outcomes in patients with acute myeloid leukaemia or myelodysplastic syndrome undergoing allogenic HCT. METHODS: The prospective, multicentre, observational, ALLogeneic Iron inVEstigators (ALLIVE) trial recruited patients at five centres in Germany...
April 5, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29625162/effective-delivery-of-hydrophobic-drugs-to-breast-mcf-7-and-liver-hepg2-cancer-cells-a-detailed-investigation-using-cytotoxicity-assays-fluorescence-imaging-and-flow-cytometry
#19
Danushika C Manatunga, Rohini M de Silva, K M Nalin de Silva, Gathsaurie Neelika Malavige, Dulharie T Wijeratne, Gareth R Williams, Chanika D Jayasinghe, Preethi V Udagama
This study aimed to develop a drug carrier system consisting of a polymer containing hydroxyapatite (HAp) shell and a magnetic core of iron oxide nanoparticles. Doxorubicin and/or curcumin were loaded into the carrier via a simple diffusion deposition approach, with encapsulation efficiencies (EE) for curcumin and doxorubicin of 93.03 ± 0.3% and 97.37 ± 0.12% respectively. The co-loading of curcumin and doxorubicin led to a total EE of 76.02 ± 0.48%. Release studies were carried out at pH 7.4 and 5.3, and revealed higher release was at pH 5...
April 3, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29618926/superparamagnetic-iron-oxide-nanoparticles-modified-with-polyethylenimine-and-galactose-for-sirna-targeted-delivery-in-hepatocellular-carcinoma-therapy
#20
Zhen Yang, Juanli Duan, Jianlin Wang, Qi Liu, Runze Shang, Xisheng Yang, Peng Lu, Congcong Xia, Lin Wang, Kefeng Dou
Introduction: A safe and effective in vivo siRNA delivery system is a prerequisite for liver tumor treatment based on siRNA cancer therapeutics. Nanoparticles based on superparamagnetic iron oxide (SPIO) provide a promising delivery system. In this study, we aimed to explore a novel nanoparticle, which is composed of SPIO. Materials and methods: The particles have a core of iron oxide that is modified by galactose (Gal) and polyethylenimine (PEI), which act as shells, providing targeted delivery of therapeutic siRNA to the liver cancer...
2018: International Journal of Nanomedicine
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