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https://www.readbyqxmd.com/read/27920637/endocrinological-abnormalities-are-a-main-feature-of-17p13-1-microduplication-syndrome-a-new-case-and-literature-review
#1
Ilenia Maini, Ivan Ivanovski, Alessandro Iodice, Simonetta Rosato, Marzia Pollazzon, Manuela Mussini, Elga F Belligni, Charles Coutton, Maria Marinelli, Veronica Barbieri, Manuela Napoli, Rosario Pascarella, Chiara Sartori, Francesca Madia, Carlo Fusco, Fabrizia Franchi, Maria E Street, Livia Garavelli
To date, 5 cases of 17p13.1 microduplications have been described in the literature. Intellectual disability was reported as the core feature, together with minor facial dysmorphisms and obesity, but a characteristic phenotype for 17p13.1 microduplication has not been delineated. Here, we describe a patient with a 1.56-Mb de novo duplication in 17p13.1, affected by mild intellectual disability, facial dysmorphisms, obesity, and diabetes. By comparing the different phenotypes of currently described cases, we delineated the main clinical features of 17p13...
November 2016: Molecular Syndromology
https://www.readbyqxmd.com/read/27903156/american-society-of-clinical-oncology-obesity-initiative-rationale-progress-and-future-directions
#2
Jennifer A Ligibel, Dana Wollins
Obesity is increasingly being linked to the risk of developing and dying from cancer. In recognition of the growing contribution of obesity to cancer risk and outcomes, ASCO made obesity and cancer one of its core initiatives in 2014. The goals of this initiative included raising awareness of the relationship between obesity and cancer, providing tools and resources to oncology providers and patients to help encourage conversations regarding weight management in cancer survivors, fostering a robust research agenda, and advocating for access to evidence-based weight management programs for cancer survivors...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27891186/relationship-between-vitamin-d-status-glycemic-control-and-cardiovascular-risk-factors-in-brazilians-with-type-2-diabetes-mellitus
#3
Maria Creusa Rolim, Bárbara Mendes Santos, Gildasio Conceição, Paulo Novis Rocha
OBJECTIVES: Determine the prevalence and identify predictors of hypovitaminosis D in patients with type 2 diabetes mellitus (T2DM); 2) correlate vitamin D levels with variables indicative of glycemic control and cardiovascular risk. RESEARCH DESIGN AND METHODS: We conducted a cross-sectional study with consecutive patients treated at a University Hospital's Endocrinology outpatient clinic located at 12°58'S latitude, between October 2012 and November 2013. Hypovitaminosis D was defined as 25-hydroxyvitamin D < 30 ng/mL (chemiluminescence)...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27760420/risks-of-metformin-in-type-2-diabetes-and-chronic-kidney-disease-lessons-learned-from-taiwanese-data
#4
Connie M Rhee, Csaba P Kovesdy, Kamyar Kalantar-Zadeh
Like other biguanide agents, metformin is an anti-hyperglycemic agent with lower tendency towards hypoglycemia compared to other anti-diabetic drugs. Given its favorable effects on serum lipids, obese body habitus, cardiovascular disease, and mortality, metformin is recommended as the first-line pharmacologic agent for type 2 diabetes in the absence of contraindications. However, as metformin accumulation may lead to type B non-hypoxemic lactic acidosis, especially in the setting of kidney injury, chronic kidney disease, and overdose, regulatory agencies such as the United States Food and Drug Administration (FDA) have maintained certain restrictions regarding its use in kidney dysfunction...
October 20, 2016: Nephron
https://www.readbyqxmd.com/read/27705028/type-2-diabetes-and-metabolic-syndrome-adipokine-levels-and-effect-of-drugs
#5
Rabia Farooq, Shajrul Amin, M Hayat Bhat, Rawoof Malik, Hilal Ahmad Wani, Sabhiya Majid
Type 2 diabetes mellitus (T2DM) is a consequence of complex interactions among multiple genetic variants and environmental risk factors. This complex disorder is also characterized by changes in various adipokines. In this study, our objective was to estimate the levels of adiponectin, leptin, and resistin (ALR) in T2DM patients, besides studying the effect of various drugs on their levels. Study participants included 400 diabetic and 300 normal patients from the Department of Endocrinology and Department of Biochemistry, Govt Medical College Srinagar...
October 5, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27667144/-lixisenatide-in-patients-with-type-2-diabetes-and-obesity-beyond-glycaemic-control
#6
M Mar Roca-Rodríguez, María Teresa Muros de Fuentes, Gonzalo Piédrola-Maroto, Miguel Quesada-Charneco, Silvia Maraver-Selfa, Francisco J Tinahones, Isabel Mancha-Doblas
AIM: To evaluate tolerance to lixisenatide and its effects on weight and metabolic control in type2 diabetes and obese patients. DESIGN: Prospective study. SETTING: Endocrinology clinics in Almeria, Granada and Malaga. PARTICIPANTS: Patients with type2 diabetes and obesity. INTERVENTIONS: Response and tolerance to lixisenatide treatment. MAIN MEASUREMENTS: Clinical and analytical data of the subjects were evaluated at baseline and after treatment...
September 22, 2016: Atencion Primaria
https://www.readbyqxmd.com/read/27614865/interaction-between-diabetes-mellitus-and-hypertension-on-risk-of-hearing-loss-in-highly-endogamous-population
#7
Abdulbari Bener, Abdulla O A A Al-Hamaq, Khalid Abdulhadi, Ahmed H Salahaldin, Loida Gansan
AIM: The aim of this study was to determine the prevalence of hearing loss and its association with type 2 diabetes mellitus (T2DM) in a highly endogamous population. DESIGN: This is a cross-sectional study. SETTING: The present study is carried out in Ear Nose Throat (ENT) and Endocrinology outpatient clinics of the Hamad General and Rumeilah Hospitals, Hamad Medical Corporation. SUBJECTS: All subjects aged between 20 and 59 years who visited the Endocrinology and ENT outpatient clinics of the Hamad Medical Corporation with hearing difficulty were included in this study during the period from January 2013 to July 2014...
September 5, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27569120/low-adoption-of-weight-loss-medications-a-comparison-of-prescribing-patterns-of-antiobesity-pharmacotherapies-and-sglt2s
#8
Catherine E Thomas, Elizabeth A Mauer, Alpana P Shukla, Samrat Rathi, Louis J Aronne
OBJECTIVE: To characterize the adoption of antiobesity pharmacotherapies, as compared with that of the newest antidiabetes pharmacotherapy, subtype 2 sodium-glucose transport protein inhibitors (SGLT2s), among prescribers in the United States. METHODS: A retrospective analysis of 2012 to 2015 data extracted from the IMS Health National Prescription Audit™ and Xponent™ assessed adoption rates of antiobesity pharmacotherapies and SGLT2s. RESULTS: The number of dispensed antidiabetes prescriptions was 15 times the number of dispensed antiobesity prescriptions...
September 2016: Obesity
https://www.readbyqxmd.com/read/27400675/subtraction-of-subcutaneous-fat-to-improve-the-prediction-of-visceral-adiposity-exploring-a-new-anthropometric-track-in-overweight-and-obese-youth
#9
H Samouda, C De Beaufort, S Stranges, J-P Van Nieuwenhuyse, G Dooms, O Keunen, S Leite, M Vaillant, M-L Lair, F Dadoun
BACKGROUND: The efficiency of traditional anthropometric measurements such as body mass index (BMI) or waist circumference (Waist C) used to replace biomedical imaging for assessing visceral adipose tissue (VAT) is still highly controversial in youth. HYPOTHESIS AND OBJECTIVES: We evaluated the most accurate model predicting VAT in overweight/obese youth, using various anthropometric measurements and their correlation with different body fat compartments, especially by testing, for the first time in youth, the hypothesis that subtracting the anthropometric measurement the most highly correlated with subcutaneous abdominal adipose tissue (SAAT) and less correlated possible with VAT from an anthropometric abdominal measurement highly correlated with visceral and total abdominal adipose tissue (TAAT), predicts VAT with higher accuracy...
July 12, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27381990/disorders-of-glucose-metabolism-in-prader-willi-syndrome-results-of-a-multicenter-italian-cohort-study
#10
D Fintini, G Grugni, S Bocchini, C Brufani, S Di Candia, A Corrias, M Delvecchio, A Salvatoni, L Ragusa, N Greggio, A Franzese, E Scarano, G Trifirò, L Mazzanti, G Chiumello, M Cappa, A Crinò
BACKGROUND AND AIMS: Prader-Willi syndrome (PWS) is characterized by a high incidence of altered glucose metabolism (AGM). However, epidemiological data on impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) are still discordant. METHODS AND RESULTS: We performed a multicenter study based on 274 PWS patients [144 females, aged 20.3 ± 10.4 yrs (range: 8.1-50.1 years)] evaluating the prevalence for AGM in the entire group, and according to age (children <10 yrs; adolescents 10-18 yrs, and adults >18 yrs), Body Mass Index (BMI = kg/m(2)), gender, genotypes (deletion or uniparental disomy for chromosome 15), and GH therapy (GHT) (untreated, previously or currently treated)...
September 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27355856/recommendations-of-the-neuroendocrinology-department-of-the-brazilian-society-of-endocrinology-and-metabolism-for-the-diagnosis-of-cushing-s-disease-in-brazil
#11
Márcio Carlos Machado, Maria Candida Barisson Vilares Fragoso, Ayrton Custódio Moreira, César Luiz Boguszewski, Leonardo Vieira, Luciana A Naves, Lucio Vilar, Luiz Antônio de Araújo, Mauro A Czepielewski, Monica R Gadelha, Nina Rosa Castro Musolino, Paulo Augusto C Miranda, Marcello Delano Bronstein, Antônio Ribeiro-Oliveira
Although it is a rare condition, the accurate diagnosis and treatment of Cushing's disease is important due to its higher morbidity and mortality compared to the general population, which is attributed to cardiovascular diseases, diabetes mellitus and infections. Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing's syndrome, abnormal findings relative to age (e.g., spinal osteoporosis and high blood pressure in young patients), weight gain associated with reduced growth rate in the pediatric population and for those with adrenal incidentalomas...
June 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27304785/a-comparison-of-the-hormonal-profile-of-early-androgenetic-alopecia-in-men-with-the-phenotypic-equivalent-of-polycystic-ovarian-syndrome-in-women
#12
Sarita Sanke, Ram Chander, Anju Jain, Taru Garg, Pravesh Yadav
IMPORTANCE: Early androgenetic alopecia (AGA) is patterned hair loss occurring before age 30 years. Early AGA in men is frequently reported as the phenotypic equivalent of polycystic ovarian syndrome (PCOS) in women, which carries the risk of developing obesity, metabolic syndrome, and cardiovascular diseases. Very few studies have been conducted to evaluate this. OBJECTIVE: To study the hormonal profile of men with early AGA and to evaluate if early AGA in men can be considered as the phenotypic equivalent of PCOS, the associated risks of which are well known...
September 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27217937/the-direct-medical-costs-of-outpatient-cares-of-type-2-diabetes-in-iran-a-retrospective-study
#13
Majid Davari, Zahra Boroumand, Masoud Amini, Abolfazl Aslani, Mohsen Hosseini
BACKGROUND: Diabetes mellitus is a chronic disease which many factors are involved and is developing considerably worldwide. Increasing aging population and obesity in the societies has improved the scale of the type 2 diabetes significantly. The aim of this study was to determine the direct medical costs of outpatient cares of diabetes in Iran. METHODS: Active patients of Isfahan Endocrinology and Metabolism Research Center (IEMRC) by the end of March 2011 were employed for data extraction...
2016: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27186461/postoperative-effects-of-laparoscopic-sleeve-gastrectomy-in-morbid-obese-patients-with-type-2-diabetes
#14
Mehmet Mihmanli, Riza Gurhan Isil, Emre Bozkurt, Uygar Demir, Cemal Kaya, Ozgur Bostanci, Canan Tulay Isil, Pinar Sayin, Sibel Oba, Feyza Yener Ozturk, Yuksel Altuntas
BACKGROUND: Laparoscopic Sleeve Gastrectomy has become one of the most popular bariatric surgery types and helps treating not only obesity but also endocrinological diseases related to obesity. Therefore we aimed to evaluate the effects of laparoscopic sleeve gastrectomy on the treatment of type 2 diabetes. METHODS: All patients, who underwent morbid obesity surgery during 2013-2014 and had a HbA1c >6 % were included in this prospective study. Demographical data, usage of oral antidiabetic drugs or insulin were recorded, and laboratory findings as HbA1c and fasting plasma glucose were evaluated preoperatively and postoperatively at the 6th and 12th months...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27183244/comparison-between-objective-measures-and-parental-behavioral-rating-scales-of-memory-and-attention-in-pediatric-endocrinology-patients
#15
Christine Limbers, Danielle Young, Stephanie Jernigan, William Bryant, Matt Stephen
: Behavioral rating scales represent one potential method for screening of cognitive functioning in routine clinical care. It is not yet known if objective performance based measures and behavioral rating scales of cognitive functioning completed by parents yield similar information in pediatric endocrinology patients. The purpose of the present study was to evaluate the associations between performance-based measures and behavioral rating scales of memory and attention/concentration completed by parents of pediatric patients with Type 1 Diabetes or obesity...
May 16, 2016: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/27166279/neuroinflammatory-and-autonomic-mechanisms-in-diabetes-and-hypertension
#16
REVIEW
Cheng Han, Matthew W Rice, Dongsheng Cai
Interdisciplinary studies in the research fields of endocrinology and immunology show that obesity-associated overnutrition leads to neuroinflammatory molecular changes, in particular in the hypothalamus, chronically causing various disorders known as elements of metabolic syndrome. In this process, neural or hypothalamic inflammation impairs the neuroendocrine and autonomic regulation of the brain over blood pressure and glucose homeostasis as well as insulin secretion, and elevated sympathetic activation has been appreciated as a critical mediator...
July 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27135093/chronic-central-serous-chorioretinopathy-as-a-presenting-symptom-of-cushing-syndrome
#17
Elon H C van Dijk, Greet Dijkman, Nienke R Biermasz, Femke M van Haalen, Alberto M Pereira, Camiel J F Boon
PURPOSE: To describe 4 patients who were diagnosed with chronic central serous chorioretinopathy (cCSC), which appeared to be the presenting symptom of Cushing syndrome (CS). METHODS: In this retrospective review of charts, all patients received extensive ophthalmologic examination and endocrinologic analyses. RESULTS: A 56-year-old man and a 49-year-old woman were treated because of bilaterally active, therapy-resistant cCSC. The clinical sign indicative for CS leading to referral to the endocrinologist was muscle weakness in the man and plethora in the woman...
August 4, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27108154/diabetes-in-vietnam
#18
REVIEW
Nguyen Thy Khue
BACKGROUND: The prevalence for diabetes, prediabetes, and gestational diabetes in Vietnam are low relative to other parts of the world, but they are increasing at alarming rates. These changes have occurred in the setting of economic and cultural transitions. OBJECTIVES: The aim of this study was to provide relevant information depicting the diabetes burden in Vietnam. METHODS: Literature was reviewed using PubMed and local Vietnamese sources, including papers published in the Vietnamese language...
November 2015: Annals of Global Health
https://www.readbyqxmd.com/read/27031655/transculturalization-recommendations-for-developing-latin-american-clinical-practice-algorithms-in-endocrinology-proceedings-of-the-2015-pan-american-workshop-by-the-american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology
#19
Jeffrey I Mechanick, R Mack Harrell, Myriam Z Allende-Vigo, Carlos Alvayero, Onix Arita-Melzer, Pablo Aschner, Pauline M Camacho, Rogelio Zacarias Castillo, Sonia Cerdas, Walmir F Coutinho, Jaime A Davidson, Jeffrey R Garber, W Timothy Garvey, Fernando Javier Lavalle González, Denis O Granados, Osama Hamdy, Yehuda Handelsman, Manuel Francisco Jiménez-Navarrete, Mark A Lupo, Enrique J Mendoza, José G Jiménez-Montero, Farhad Zangeneh
The American Association of Clinical Endocrinologists (AACE) and American College of Endocrinology (ACE) convened their first Workshop for recommendations to optimize Clinical Practice Algorithm (CPA) development for Latin America (LA) in diabetes (focusing on glycemic control), obesity (focusing on weight loss), thyroid (focusing on thyroid nodule diagnostics), and bone (focusing on postmenopausal osteoporosis) on February 28, 2015, in San Jose, Costa Rica. A standardized methodology is presented incorporating various transculturalization factors: resource availability (including imaging equipment and approved pharmaceuticals), health care professional and patient preferences, lifestyle variables, socio-economic parameters, web-based global accessibility, electronic implementation, and need for validation protocols...
April 2016: Endocrine Practice
https://www.readbyqxmd.com/read/26957494/mechanisms-in-endocrinology-tissue-specific-activation-of-cortisol-in-cushing-s-syndrome
#20
REVIEW
Stuart A Morgan, Zaki K Hassan-Smith, Gareth G Lavery
Glucocorticoids are widely prescribed for their anti-inflammatory properties, but have 'Cushingoid' side effects including visceral obesity, muscle myopathy, hypertension, insulin resistance, type 2 diabetes mellitus, osteoporosis, and hepatic steatosis. These features are replicated in patients with much rarer endogenous glucocorticoid (GC) excess (Cushing's syndrome), which has devastating consequences if left untreated. Current medical therapeutic options that reverse the tissue-specific consequences of hypercortisolism are limited...
August 2016: European Journal of Endocrinology
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