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https://www.readbyqxmd.com/read/29769545/short-term-temporal-memory-in-idiopathic-and-parkin-associated-parkinson-s-disease
#1
Bertrand Degos, Ilhame Ameqrane, Sophie Rivaud-Péchoux, Pierre Pouget, Marcus Missal
In a rapidly changing environment, we often know when to do something before we have to do it. This preparation in the temporal domain is based on a 'perception' of elapsed time and short-term memory of previous stimulation in a similar context. These functions could be perturbed in Parkinson's disease. Therefore, we investigated their role in eye movement preparation in sporadic Parkinson's disease and in a very infrequent variant affecting the Parkin gene. We used a simple oculomotor task where subjects had to orient to a visual target and movement latency was measured...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29766038/frontal-eye-field-inactivation-reduces-saccade-preparation-in-the-superior-colliculus-but-does-not-alter-how-preparatory-activity-relates-to-saccades-of-a-given-latency
#2
Suryadeep Dash, Tyler R Peel, Stephen G Lomber, Brian D Corneil
A neural correlate for saccadic reaction times (SRTs) in the gap saccade task is the level of low-frequency activity in the intermediate layers of the superior colliculus (iSC) just before visual target onset: greater levels of such preparatory iSC low-frequency activity precede shorter SRTs. The frontal eye fields (FEFs) are one likely source of iSC preparatory activity, since FEF preparatory activity is also inversely related to SRT. To better understand the FEF's role in saccade preparation, and the way in which such preparation relates to SRT, in two male rhesus monkeys, we compared iSC preparatory activity across unilateral reversible cryogenic inactivation of the FEF...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29761297/severe-neurologic-complications-of-immune-checkpoint-inhibitors-a-single-center-review
#3
Sarah Mancone, Thomas Lycan, Tamjeed Ahmed, Umit Topaloglu, Andrew Dothard, William J Petty, Roy E Strowd
BACKGROUND: Immune checkpoint inhibitors (ICIs) are a promising class of anticancer drugs associated with immune-related adverse events (IRAEs). In registration studies of selected cancer populations, neurologic IRAEs were rare. Post-marketing experience describing their prevalence in clinical practice continues to be reported. METHODS: A retrospective cohort of patients treated at our institution with ICIs from 2005 to 2017 was identified. Patients with new neurologic ICD codes documented during or after ICI treatment were enrolled...
May 14, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29757553/-the-manifestation-of-videonystamography-in-the-patients-with-posterior-circulation-ischemia-vertigo
#4
Hao Wei Wang, Ying Guo, Jing Zhou, Hui Fang Zhou
Objective: To investigate the changes of vedionystamography(VNG)in patients with posterior circulation ischemia vertigo(PCIV). Method: Fifty patients who complained of vertigo and imbalance with PCI were selected as experimental group for testing of visual nystamography(VNG).Thirty normal subjects were chosen as control group.The result was analyzed. Result: The results of VNG in PCIV group and the control group were compared.The abnormal ratio were as follows:(4%,0; P >0.05)for Spontaneous nystagmus,(68%,10%; P <0...
January 20, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29749597/-nuclear-paralysis-of-the-oculomotor-nerve-within-the-context-of-traumatic-brain-injury
#5
P Roman-Pena, E Aran-Echabe, M Raposo-Furelos, M Gelabert-Gonzalez
No abstract text is available yet for this article.
May 16, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29746441/cognitive-profile-of-children-with-intracranial-germ-cell-tumor-according-to-tumor-location
#6
Virginie Coutinho, Georges Dellatolas, Clemence Castaignede-Lalande, Audrey Longaud-Vales, Virginie Kieffer, Lea Guerrini-Rousseau, Jacques Grill, Dominique Valteau-Couanet, Christelle Dufour
PURPOSE: The purpose of this study was to evaluate the long-term cognitive sequelae and to describe the neuropsychological profile of patients with intracranial germ cell tumors according to tumor location (pineal or suprasellar site). PATIENTS AND METHODS: Forty-five children treated at Gustave Roussy between 1991 and 2010 were assessed with neuropsychological tests to measure IQ, memory, visuospatial, motor, and executive skills at a mean delay of 4.2 years after diagnosis...
May 9, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29741470/markers-of-cognitive-function-in-individuals-with-metabolic-disease-morquio-syndrome-and-tyrosinemia-type-iii
#7
James Blundell, Steven Frisson, Anupam Chakrapani, Shauna Kearney, Suresh Vijay, Anita MacDonald, Paul Gissen, Chris Hendriksz, Andrew Olson
We characterized cognitive function in two metabolic diseases. MPS-IVa (mucopolysaccharidosis IVa, Morquio) and tyrosinemia type III individuals were assessed using tasks of attention, language and oculomotor function. MPS-IVa individuals were slower in visual search, but the display size effects were normal, and slowing was not due to long reaction times (ruling out slow item processing or distraction). Maintaining gaze in an oculomotor task was difficult. Results implicated sustained attention and task initiation or response processing...
May 2018: Cognitive Neuropsychology
https://www.readbyqxmd.com/read/29736264/clinical-management-of-friedreich-s-ataxia-a-report-of-two-cases
#8
Yannis Dionyssiotis, Athina Kapsokoulou, Anna Danopoulou, Maria Kokolaki, Athina Vadalouka
Introduction: Friedreich's ataxia (FDRA) is the most common autosomal recessive, early-onset ataxia. FDRA is a progressive neurodegenerative disease that mainly affects the posterior (dorsal) columns of the spinal cord resulting in sensory ataxia. It manifests in initial symptoms of poor coordination and gait disturbance. Case presentation: We present two cases, a brother (54 years old) and sister (56 years old), with FDRA that are chronically institutionalized for incomplete quadriplegia without spasticity...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29734383/eyes-closed-hybrid-brain-computer-interface-employing-frontal-brain-activation
#9
Jaeyoung Shin, Klaus-Robert Müller, Han-Jeong Hwang
Brain-computer interfaces (BCIs) have been studied extensively in order to establish a non-muscular communication channel mainly for patients with impaired motor functions. However, many limitations remain for BCIs in clinical use. In this study, we propose a hybrid BCI that is based on only frontal brain areas and can be operated in an eyes-closed state for end users with impaired motor and declining visual functions. In our experiment, electroencephalography (EEG) and near-infrared spectroscopy (NIRS) were simultaneously measured while 12 participants performed mental arithmetic (MA) and remained relaxed (baseline state: BL)...
2018: PloS One
https://www.readbyqxmd.com/read/29732973/progressive-supranuclear-palsy-neuropsychopathological-therapeutical-and-bioethical-aspects
#10
Ignazio Vecchio, Cristina Tornali, Giulia Malaguarnera, Nicola Luigi Bragazzi, Michele Malaguarnera
The progressive supranuclear palsy is a progressive neurodegenerative disease characterized by Parkinsonism, oculomotor abnormalities, early postural instability and cognitive impairment. Neurodegeneration in PSP is associated with tau protein, but the mechanisms by which tau abnormalities lead to cell dysfunction and death are not well understood. Neuro-behavioural problems related to the fear and loss of autonomy can determinate many bioethical implications. Careful planning involving patients' families, academic and industry researchers were necessary to ensure improvement in quality of life...
May 6, 2018: Current Alzheimer Research
https://www.readbyqxmd.com/read/29726781/microsurgical-anatomy-of-the-subthalamic-nucleus-correlating-fiber-dissection-results-with-3-t-magnetic-resonance-imaging-using-neuronavigation
#11
Abuzer Güngör, Şevki Serhat Baydın, Vanessa M Holanda, Erik H Middlebrooks, Cihan Isler, Bekir Tugcu, Kelly Foote, Necmettin Tanriover
OBJECTIVE Despite the extensive use of the subthalamic nucleus (STN) as a deep brain stimulation (DBS) target, unveiling the extensive functional connectivity of the nucleus, relating its structural connectivity to the stimulation-induced adverse effects, and thus optimizing the STN targeting still remain challenging. Mastering the 3D anatomy of the STN region should be the fundamental goal to achieve ideal surgical results, due to the deep-seated and obscure position of the nucleus, variable shape and relatively small size, oblique orientation, and extensive structural connectivity...
May 4, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29722327/structural-neural-connectivity-of-the-vestibular-nuclei-in-the-human-brain-a-diffusion-tensor-imagings-study
#12
Sung Ho Jang, Mi Young Lee, Sang Seok Yeo, Hyeok Gyu Kwon
Many animal studies have reported on the neural connectivity of the vestibular nuclei (VN). However, little is reported on the structural neural connectivity of the VN in the human brain. In this study, we attempted to investigate the structural neural connectivity of the VN in 37 healthy subjects using diffusion tensor tractography. A seed region of interest was placed on the isolated VN using probabilistic diffusion tensor tractography. Connectivity was defined as the incidence of connection between the VN and each brain region...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29721727/schizotypy-and-smooth-pursuit-eye-movements-as-potential-endophenotypes-of-obsessive-compulsive-disorder
#13
Katharina Bey, Inga Meyhöfer, Leonhard Lennertz, Rosa Grützmann, Stephan Heinzel, Christian Kaufmann, Julia Klawohn, Anja Riesel, Ulrich Ettinger, Norbert Kathmann, Michael Wagner
Patients with obsessive-compulsive disorder (OCD) show dysfunctions of the fronto-striatal circuitry, which imply corresponding oculomotor deficits including smooth pursuit eye movements (SPEM). However, evidence for a deficit in SPEM is inconclusive, with some studies reporting reduced velocity gain while others did not find any SPEM dysfunctions in OCD patients. Interestingly, psychosis-like traits have repeatedly been linked to both OCD and impaired SPEM. Here, we examined a large sample of n = 168 patients with OCD, n = 93 unaffected first-degree relatives and n = 171 healthy control subjects to investigate whether elevated levels of schizotypy and SPEM deficits represent potential endophenotypes of OCD...
May 2, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29718589/comorbid-inner-ear-disorders-in-50-patients-with-congenital-nystagmus
#14
Yun-Chen Huang, Shuo-Yen Hsu, Yi-Ho Young
Congenital nystagmus patients had abnormal oculomotor function because congenital nystagmus was superimposed on the oculomotor traces. One-third of them had comorbid inner ear disorders. Two-thirds of them lacked inner ear disorders, but just sought evaluations at a neurotological clinic. This article is protected by copyright. All rights reserved.
May 2, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29717643/the-national-institute-of-neurological-disorders-and-stroke-and-department-of-defense-sport-related-concussion-common-data-elements-version-1-0-recommendations
#15
Steven P Broglio, Anthony P Kontos, Harvey Levin, Kathryn Schneider, Elisabeth A Wilde, Robert C Cantu, Nina Feddermann-Demont, Gordon Fuller, Isabelle Gagnon, Gerry Gioia, Christopher C Giza, Grace Sophia Griesbach, John J Leddy, Michael L Lipton, Andrew Mayer, Thomas McAllister, Michael McCrea, Lara McKenzie, Margot Putukian, Stefano Signoretti, Stacy J Suskauer, Robert Tamburro, Michael Turner, Keith Owen Yeates, Roger Zemek, Sherita Ala'i, Joy Esterlitz, Katelyn Gay, Patrick S F Bellgowan, Kristen Joseph
AIM: Through a partnership with the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), and Department of Defense (DoD), the development of Sport-Related Concussion (SRC) Common Data Elements (CDEs) was initiated. The aim of this collaboration was to increase the efficiency and effectiveness of clinical research studies and clinical treatment outcomes, increase data quality, facilitate data sharing across studies, reduce study start-up time, more effectively aggregate information into metadata results, and educate new clinical investigators...
May 2, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29709941/a-case-of-miller-fisher-syndrome-mimicking-tolosa-hunt-syndrome
#16
Masahiro Oomura, Yuto Uchida, Keita Sakurai, Takanari Toyoda, Kenji Okita, Noriyuki Matsukawa
We herein report a patient with Miller Fisher syndrome mimicking Tolosa-Hunt syndrome. A 47-year-old man presented with right orbital pain and diplopia. On a neurological examination, he had right oculomotor nerve palsy and diminished deep tendon reflexes. Brain magnetic resonance imaging failed to show any parenchymal lesions; however, the bilateral oculomotor nerves were gadolinium-enhanced. The presence of a triad of orbital pain, ipsilateral oculomotor nerve palsy, and a rapid response to steroid therapy met the diagnostic criteria for Tolosa-Hunt syndrome...
April 27, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29705937/isolated-oculomotor-palsy-due-to-acute-ischemic-midbrain-stroke
#17
Cornelius Kronlage, Athina Papadopoulou, Gian Marco De Marchis
No abstract text is available yet for this article.
April 28, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29686605/visual-cerebellar-pathways-and-their-roles-in-the-control-of-avian-flight
#18
REVIEW
Douglas R Wylie, Cristián Gutiérrez-Ibáñez, Andrea H Gaede, Douglas L Altshuler, Andrew N Iwaniuk
In this paper, we review the connections and physiology of visual pathways to the cerebellum in birds and consider their role in flight. We emphasize that there are two visual pathways to the cerebellum. One is to the vestibulocerebellum (folia IXcd and X) that originates from two retinal-recipient nuclei that process optic flow: the nucleus of the basal optic root (nBOR) and the pretectal nucleus lentiformis mesencephali (LM). The second is to the oculomotor cerebellum (folia VI-VIII), which receives optic flow information, mainly from LM, but also local visual motion information from the optic tectum, and other visual information from the ventral lateral geniculate nucleus (Glv)...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29685738/-idiopathic-orbital-inflammatory-syndrome-report-of-24-cases
#19
S Khochtali, M Zayani, I Ksiaa, I Ben Meriem, S Zaouali, B Jelliti, M Khairallah
BACKGROUND: Idiopathic orbital inflammatory syndrome (IOIS) is an inflammatory condition of unknown etiology. The inflammation may affect all the structures within the orbit (anterior, diffuse, apical, myositic, dacryoadenitis) and corresponds to uniquely orbital inflammation without an identifiable local cause or systemic disease. The goal of this study is to describe the clinical and radiographic characteristics of IOIS and discuss the role of orbital biopsy in this condition. PATIENTS AND METHODS: This is a retrospective review of the charts of 24 patients diagnosed with IOIS at Fattouma Bourguiba hospital, Monastir, Tunisia, from January 2007 to December 2015...
April 20, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29685009/sudden-onset-unilateral-ptosis-induced-by-pituitary-macroadenoma-with-false-positive-jolly-and-neostigmine-tests
#20
G X Shen, K J Wu, Z Chen, Y F Gao, G X Nan
The development of ptosis as a consequence of pituitary tumor is an exceptionally rare occurrence. Here, we describe the case of sudden-onset unilateral ptosis induced by pituitary macroadenoma. The condition was characterized by false-positive Jolly and neostigmine tests. These findings mimic oculomotor nerve palsy and make the correct diagnostics rather challenging. The case points to the fact that patients with acquired ptosis need detailed neuroophthalmological examination.
March 2018: Journal of Biological Regulators and Homeostatic Agents
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