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medication overuse headache

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https://www.readbyqxmd.com/read/28229320/primary-headache-disorders-in-the-adult-general-population-of-pakistan-a-cross-sectional-nationwide-prevalence-survey
#1
A A Herekar, A Ahmad, U L Uqaili, B Ahmed, J Effendi, S Z Alvi, M A Shahab, U Javed, A D Herekar, Rafiq Khanani, T J Steiner
BACKGROUND: The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include almost all of Eastern Mediterranean Region (EMR). We report a nationwide population-based study in Pakistan, an EMR country with the sixth largest population in the world, conducted as a project within the Global Campaign against Headache. METHODS: We surveyed six locations from the four provinces of Pakistan: Punjab, Sindh, Khyber Pakhtunkhwa and Baluchistan...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28220377/altered-functional-connectivity-architecture-of-the-brain-in-medication-overuse-headache-using-resting-state-fmri
#2
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Zhao Dong, Lin Ma, Shengyuan Yu
BACKGROUND: Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the altered functional network with the identified brain regions. This may be an effective assessment strategy for headache research. This study is to investigate the RSFC architecture changes of the brain in the patients with medication overuse headache (MOH) using FCD and RSFC methods...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28161874/mindfulness-and-pharmacological-prophylaxis-after-withdrawal-from-medication-overuse-in-patients-with-chronic-migraine-an-effectiveness-trial-with-a-one-year-follow-up
#3
Licia Grazzi, Emanuela Sansone, Alberto Raggi, Domenico D'Amico, Andrea De Giorgio, Matilde Leonardi, Laura De Torres, Francisco Salgado-García, Frank Andrasik
BACKGROUND: Chronic Migraine (CM) is a disabling condition, worsened when associated with Medication Overuse (MO). Mindfulness is an emerging technique, effective in different pain conditions, but it has yet to be explored for CM-MO. We report the results of a study assessing a one-year course of patients' status, with the hypothesis that the effectiveness of a mindfulness-based approach would be similar to that of conventional prophylactic treatments. METHODS: Patients with CM-MO (code 1...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28160280/medication-overuse-headache-pathophysiological-insights-from-structural-and-functional-brain-mri-research
#4
Todd J Schwedt, Catherine D Chong
BACKGROUND: Research imaging of brain structure and function has helped to elucidate the pathophysiology of medication overuse headache (MOH). METHODS: This is a narrative review of imaging research studies that have investigated brain structural and functional alterations associated with MOH. Studies included in this review have investigated abnormal structure and function of pain processing regions in people with MOH, functional patterns that might predispose individuals to development of MOH, similarity of brain functional patterns in patients with MOH to those found in people with addiction, brain structure that could predict headache improvement following discontinuation of the overused medication, and changes in brain structure and function after discontinuation of medication overuse...
February 3, 2017: Headache
https://www.readbyqxmd.com/read/28155029/texture-features-of-periaqueductal-gray-in-the-patients-with-medication-overuse-headache
#5
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma, Shengyuan Yu
BACKGROUND: Periaqueductal gray (PAG) is the descending pain modulatory center, and PAG dysfunction had been recognized in migraine. Here we propose to investigate altered PAG texture features (quantitative approach for extracting texture descriptors for images) in the patients with medication-overuse headache (MOH) based on high resolution brain structural image to understand the MOH pathogenesis. METHODS: The brain structural images were obtained from 32 normal controls (NC) and 44 MOH patients on 3...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28144808/volume-gain-of-periaqueductal-gray-in-medication-overuse-headache
#6
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma, Shengyuan Yu
BACKGROUND: Periaqueductal gray (PAG) is a substantial descending pain modulatory center, and previous voxel-based morphometry study confirmed the clusters with increased volume in PAG region in medication-overuse headache (MOH). The aim of this study is to investigate altered PAG volume in MOH using an automated PAG segment method to measure the true PAG volume. METHODS: High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 22 patients with MOH and 22 normal controls (NC)...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28127753/a-prospective-cohort-study-of-outpatient-interdisciplinary-rehabilitation-of-chronic-headache-patients
#7
Steven J Krause, Mark J Stillman, Deborah E Tepper, Deborah Zajac
OBJECTIVE: To evaluate the efficacy of an intensive outpatient program designed to improve functioning and reduce psychological impairment in chronic headache patients. BACKGROUND: Chronic headaches, occurring 15 or more days per month, for three or more months, may arise from multiple International Classification of Headache Disorders diagnoses: Chronic Migraine, Chronic Tension Type Headache, New Daily Persistent Headache, Chronic Post Traumatic Headaches, and Medication Overuse Headache...
January 27, 2017: Headache
https://www.readbyqxmd.com/read/28049513/neural-hyperactivity-in-the-amygdala-induced-by-chronic-treatment-of-rats-with-analgesics-may-elucidate-the-mechanisms-underlying-psychiatric-comorbidities-associated-with-medication-overuse-headache
#8
Aree Wanasuntronwong, Ukkrit Jansri, Anan Srikiatkhachorn
BACKGROUND: Patients with medication-overuse headache suffer not only from chronic headache, but often from psychiatric comorbidities, such as anxiety and depression. The mechanisms underlying these comorbidities are unclear, but the amygdala is likely to be involved in their pathogenesis. To investigate the mechanisms underlying the comorbidities we used elevated plus maze and open field tests to assess anxiety-like behavior in rats chronically treated with analgesics. We measured the electrical properties of neurons in the amygdala, and examined the cortical spreading depression (CSD)-evoked expression of Fos in the trigeminal nucleus caudalis (TNC) and amygdala of rats chronically treated with analgesics...
January 3, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28028803/cortical-alterations-in-medication-overuse-headache
#9
Franz Riederer, Marie Schaer, Andreas R Gantenbein, Roger Luechinger, Lars Michels, Marihan Kaya, Spyridon Kollias, Peter S Sándor
OBJECTIVE: Using surface-based morphometry we aimed to provide a detailed examination of cortical alterations in medication-overuse headache (MOH), by disentangling between altered cortical thickness and gyrification (folding). BACKGROUND: In MOH, pain modulation is probably dysfunctional at the cortical and subcortical level, resulting in a disequilibrium between pain inhibition and facilitation. Both increased and decreased cortical volumes have been reported in individuals with MOH...
February 2017: Headache
https://www.readbyqxmd.com/read/28007591/the-effectiveness-of-treatments-for-patients-with-medication-overuse-headache-a-systematic-review-and-meta-analysis
#10
REVIEW
Maaike J de Goffau, Andre R E Klaver, Marjolein G Willemsen, Patrick J E Bindels, Arianne P Verhagen
: Worldwide, approximately 1 to 2% of the adult population suffers from chronic headache due to overuse of pain medication. Guidelines recommend acute withdrawal of medication, but the optimal treatment remains unknown. We aimed to evaluate the benefit of treatments for patients with medication overuse headache (MOH). We performed an extensive literature search until November 2015, selecting randomized controlled trials that evaluated interventions for adults with MOH. Two authors assessed the eligible trials and extracted data...
December 20, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27998893/management-of-children-and-young-people-with-headache
#11
William P Whitehouse, Shakti Agrawal
Headache is very common in children and young people. The correct advice and treatment requires consideration of a wide differential diagnosis between primary and secondary headaches, and also of the different types of primary headache. The International Classification of Headache Disorders gives useful descriptions and diagnostic criteria that are especially useful for primary headaches. The National Institute for Health and Care Excellence (NICE) Clinical Guideline 150 provides evidence-based recommendations on treatments for adults and young people from age 12 years...
December 20, 2016: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/27957623/real-life-data-in-115-chronic-migraine-patients-treated-with-onabotulinumtoxin-a-during-more-than-one-year
#12
I Aicua-Rapun, E Martínez-Velasco, A Rojo, A Hernando, M Ruiz, A Carreres, E Porqueres, S Herrero, F Iglesias, A L Guerrero
BACKGROUND: OnabotulinumtoxinA (OnabotA) is effective in Chronic Migraine (CM) during first year of treatment and longer. In real clinical setting, CM patients with acute Medication Overuse (MO) or concurrently receiving oral preventatives are treated with OnabotA. We aim to assess evolution of CM patients beyond first year on OnabotA. METHODS: Data were retrospectively collected in three headache units. We analyzed cases who had received at least five sessions of OnabotA according to PREEMPT protocol...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27940881/long-term-predictors-of-remission-in-patients-treated-for-medication-overuse-headache-at-a-specialized-headache-center-a-prospective-cohort-study
#13
Jasna J Zidverc-Trajkovic, Tatjana Pekmezovic, Zagorka Jovanovic, Aleksandra Pavlovic, Milija Mijajlovic, Aleksandra Radojicic, Nadezda Sternic
OBJECTIVE: To evaluate long-term predictors of remission in patients with medication-overuse headache (MOH) by prospective cohort study. BACKGROUND: Knowledge regarding long-term predictors of MOH outcome is limited. METHODS: Two hundred and forty MOH patients recruited from 2000 to 2005 were included in a one-year follow-up study and then subsequently followed until 31 December 2013. The median follow-up was three years (interquartile range, three years)...
December 9, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27924616/the-prevalence-of-primary-headache-disorders-in-ethiopia
#14
Mehila Zebenigus, Redda Tekle-Haimanot, Dawit K Worku, Hallie Thomas, Timothy J Steiner
BACKGROUND: Knowledge of the epidemiology of primary headache disorders in sub-Saharan Africa (SSA) remains very limited. We performed a population-based survey in rural and urban areas of Ethiopia, using methods similar to those of an earlier study in Zambia and tested in multiple other countries by Lifting The Burden. METHODS: In a cross-sectional survey we visited households unannounced in four regions of Ethiopia: the mostly urban populations in Addis Ababa and its environs and rural populations of selected districts in Oromia, Amhara and South Nations Nationalities and People's Regions States (SNNPRS)...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27902848/topiramate-in-migraine-prevention-a-2016-perspective
#15
Stephen D Silberstein
BACKGROUND: In evidence-based guidelines published in 2000, topiramate was a third-tier migraine preventive with no scientific evidence of efficacy; recommendation for its use reflected consensus opinion and clinical experience. Its neurostabilizing activity, coupled with its favorable weight profile, made topiramate an attractive alternative to other migraine preventives that caused weight gain. When guidelines for migraine prevention in episodic migraine were published in 2012, topiramate was included as a first-line option based on double-blind, randomized controlled trials involving nearly 3000 patients...
January 2017: Headache
https://www.readbyqxmd.com/read/27901275/peripheral-nerve-blocks-for-the-treatment-of-headache-in-older-adults-a-retrospective-study
#16
Jacob R Hascalovici, Matthew S Robbins
OBJECTIVE: The objective of this study is to provide demographical and clinical descriptions of patients age 65 years old and older who were treated with peripheral nerve blocks (PNBs) at our institution and evaluate the safety and efficacy of this treatment. BACKGROUND: Headache disorders are common, disabling chronic neurological diseases that often persist with advancing age. Geriatric headache management poses unique therapeutic challenges because of considerations of comorbidity, drug interactions, and adverse effects...
January 2017: Headache
https://www.readbyqxmd.com/read/27882516/risk-of-medication-overuse-headache-across-classes-of-treatments-for-acute-migraine
#17
REVIEW
Kristian Thorlund, Christina Sun-Edelstein, Eric Druyts, Steve Kanters, Shanil Ebrahim, Rahul Bhambri, Elodie Ramos, Edward J Mills, Michel Lanteri-Minet, Stewart Tepper
BACKGROUND: The most commonly prescribed medications used to treat migraine acutely are single analgesics, ergots, opioids, and triptans. Due to varying mechanisms of action across drug classes, there is reason to believe that some classes may be less likely than others to elicit Medication Overuse Headache (MOH) than others. We therefore aimed to determine whether certain classes of acute migraine drugs are more likely to elicit MOH than others. METHODS: A comprehensive systematic literature was conducted to identify studies of varying designs that reported on MOH within the considered treatment classes...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27861826/medication-overuse-headache-protocols-and-outcomes-in-149-consecutive-patients-in-a-tertiary-brazilian-headache-center
#18
Abouch V Krymchantowski, Stewart J Tepper, Carla Jevoux, Marcelo Valença
AIM: Medication-overuse headache (MOH) is a challenging clinical disorder often resulting in frustration for patients and physicians. Adherence issues are common and limited treatment evidence is an obstacle to effective care. Individual bias usually directs the treatment. The aim of this study was to evaluate outcome and treatment strategies in consecutive MOH patients from a tertiary center. METHODS: Every consecutive patient seen between January and December 2014 with the diagnosis of MOH was included...
January 2017: Headache
https://www.readbyqxmd.com/read/27861823/predictors-of-12-months-relapse-after-withdrawal-treatment-in-hospitalized-patients-with-chronic-migraine-associated-with-medication-overuse-a-longitudinal-observational-study
#19
Alberto Raggi, Ambra M Giovannetti, Matilde Leonardi, Emanuela Sansone, Silvia Schiavolin, Marcella Curone, Licia Grazzi, Susanna Usai, Domenico D'Amico
BACKGROUND: Studies addressing relapse rates conflate relapse into chronic migraine (CM) and medication overuse (MO), and the consequent need to repeat withdrawal. We aim to identify 12-months predictors of relapse into CM (based on headaches frequency) separately from occurrence of another structured withdrawal. METHODS: Hospitalized patients with CM-MO under withdrawal were enrolled. Candidate predictors included demographic, disability, quality of life, depression scores, general self-efficacy, social support, headaches frequency and intensity, class of overused medications, history of withdrawal treatment in the three years prior to enrollment, attendance to emergency room (ER) between enrollment and follow-up, nonattendance to outpatient neurological examinations...
January 2017: Headache
https://www.readbyqxmd.com/read/27819415/characteristics-of-elderly-onset-%C3%A2-65-years-headache-diagnosed-using-the-international-classification-of-headache-disorders-third-edition-beta-version
#20
Tae Jin Song, Yong Jae Kim, Byung Kun Kim, Byung Su Kim, Jae Moon Kim, Soo Kyoung Kim, Heui Soo Moon, Myoung Jin Cha, Kwang Yeol Park, Jong Hee Sohn, Min Kyung Chu, Soo Jin Cho
BACKGROUND AND PURPOSE: New-onset headache in elderly patients is generally suggestive of a high probability of secondary headache, and the subtypes of primary headache diagnoses are still unclear in the elderly. This study investigated the characteristics of headache with an older age at onset (≥65 years) and compared the characteristics between younger and older age groups. METHODS: We prospectively collected demographic and clinical data of 1,627 patients who first visited 11 tertiary hospitals in Korea due to headache between August 2014 and February 2015...
October 2016: Journal of Clinical Neurology
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