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https://www.readbyqxmd.com/read/27911772/c-terminal-domain-ctd-phosphatase-links-rho-gtpase-signaling-to-pol-ii-ctd-phosphorylation-in-arabidopsis-and-yeast
#1
Bo Zhang, Guohua Yang, Yu Chen, Yihong Zhao, Peng Gao, Bo Liu, Haiyang Wang, Zhi-Liang Zheng
Rho GTPases, including the Rho, Cdc42, Rac, and ROP subfamilies, act as pivotal signaling switches in various growth and developmental processes. Compared with the well-defined role of cytoskeletal organization in Rho signaling, much less is known regarding transcriptional regulation. In a mutant screen for phenotypic enhancers of transgenic Arabidopsis plants expressing a constitutively active form of ROP2 (designated CA1-1), we identified RNA polymerase II (Pol II) C-terminal domain (CTD) phosphatase-like 1 (CPL1) as a transcriptional regulator of ROP2 signaling...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27911090/antitumor-activity-of-portulaca-oleracea-l-polysaccharide-on-hela-cells-through-inducing-tlr4-nf-%C3%AE%C2%BAb-signaling
#2
Rui Zhao, Tao Zhang, Baoling Ma, Xing Li
Abstarct We have previously shown that Portulaca oleracea L. polysaccharide (POL-P3b) possesses the ability to inhibit cervical cancer cell growth in vitro and in vivo. In this study, we explored how toll-like receptor 4 (TLR4) signaling correlated with the antitumor mechanism of POL-P3b. Western blotting was utilized to detect the expression of TLR4 and the downstream signaling pathway. The level of inflammatory mediator was quantified using enzyme-linked immunosorbent assay (ELISA) kits. The effects of POL-P3b on the proliferation and apoptosis in HeLa cells were determined by WST-8 assay and Hoechst 33342/propidium iodide (PI) assay...
December 2, 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27909108/case-1-acute-onset-vomiting-fever-and-bulging-fontanelle-in-a-7-month-old-boy
#3
Clarissa Fernandez-Pol, Matthew Ben Wallenstein, Ian Chua
No abstract text is available yet for this article.
December 2016: Pediatrics in Review
https://www.readbyqxmd.com/read/27908992/first-complete-genome-sequence-of-a-simian-foamy-virus-isolate-from-a-cynomolgus-macaque
#4
Koji Sakai, Yasushi Ami, Yuriko Suzaki, Tetsuro Matano
We report here the first complete proviral genome sequence (DDBJ/ENA/GenBank accession no. LC094267) of a simian foamy virus, SFVmfa/Cy5061, isolated from a cynomolgus macaque (Macaca fascicularis). This proviral genome consists of 12,965 nucleotides and has five open reading frames, gag, pol, env, tas, and bet, as with other foamy viruses.
December 1, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27908676/effect-of-selective-dorsal-rhizotomy-on-daily-care-and-comfort-in-non-walking-children-and-adolescents-with-severe-spasticity
#5
A I Buizer, P E M van Schie, E A M Bolster, W J van Ouwerkerk, R L Strijers, L A van de Pol, A Stadhouder, J G Becher, R J Vermeulen
BACKGROUND: In non-walking children with severe spasticity, daily care can be difficult and many patients suffer from pain. Selective dorsal rhizotomy (SDR) reduces spasticity in the legs, and therefore has the potential to improve daily care and comfort. AIM: To examine effects of SDR on daily care and comfort in non-walking children with severe spasticity due to different underlying neurological conditions. METHODS: Medical history, changes in daily care and comfort and satisfaction with outcome were assessed retrospectively in non-walking children who underwent SDR in our center, with a mean follow-up of 1y 7m (range 11m-4y 3m)...
October 22, 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27908005/occurrence-and-stability-of-chimera-states-in-coupled-externally-excited-oscillators
#6
Dawid Dudkowski, Yuri Maistrenko, Tomasz Kapitaniak
We studied the phenomenon of chimera states in networks of non-locally coupled externally excited oscillators. Units of the considered networks are bi-stable, having two co-existing attractors of different types (chaotic and periodic). The occurrence of chimeras is discussed, and the influence of coupling radius and coupling strength on their co-existence is analyzed (including typical bifurcation scenarios). We present a statistical analysis and investigate sensitivity of the probability of observing chimeras to the initial conditions and parameter values...
November 2016: Chaos
https://www.readbyqxmd.com/read/27907076/clinical-determinants-of-hiv-1b-between-host-evolution-and-their-association-with-drug-resistance-in-pediatric-patients
#7
Israel Pagán, Patricia Rojas, José Tomás Ramos, África Holguín
Understanding the factors that modulate the evolution of virus populations is essential to design efficient control strategies. Mathematical models predict that factors affecting viral within-host evolution may also determine that at the between-host level. Although HIV-1 within-host evolution has been associated with clinical factors used to monitor AIDS progression, such as patient age, CD4 cells count, viral load, and antiretroviral experience, little is known about the role of these clinical factors in determining between-host HIV-1 evolution...
2016: PloS One
https://www.readbyqxmd.com/read/27907009/moderate-levels-of-pre-treatment-hiv-1-antiretroviral-drug-resistance-detected-in-the-first-south-african-national-survey
#8
Kim Steegen, Sergio Carmona, Michelle Bronze, Maria A Papathanasopoulos, Gert van Zyl, Dominique Goedhals, William MacLeod, Ian Sanne, Wendy S Stevens
BACKGROUND: In order to assess the level of transmitted and/or pre-treatment antiretroviral drug resistance to HIV-1, the World Health Organization (WHO) recommends that regular surveys are conducted. This study's objective was to assess the frequency of HIV-1 antiretroviral drug resistance in patients initiating antiretroviral treatment (ART) in the public sector throughout South Africa. METHODS: A prospective cross-sectional survey was conducted using probability proportional to size sampling...
2016: PloS One
https://www.readbyqxmd.com/read/27906510/thermohydrogel-containing-melanin-for-photothermal-cancer-therapy
#9
Miri Kim, Hyun Soo Kim, Min Ah Kim, Hyanghwa Ryu, Hwan-Jeong Jeong, Chang-Moon Lee
Melanin is an effective absorber of light and can extend to near infrared (NIR) regions. In this study, a natural melanin is presented as a photothermal therapeutic agent (PTA) because it provides a good photothermal conversion efficiency, shows biodegradability, and does not induce long-term toxicity during retention in vivo. Poloxamer solution containing melanin (Pol-Mel) does not show any precipitation and shows sol-gel transition at body temperature. After irradiation from 808 nm NIR laser at 1.5 W cm(-2) for 3 min, the photothermal conversion efficiency of Pol-Mel is enough to kill cancer cells in vitro and in vivo...
December 1, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27904513/relationship-between-visual-status-and-functional-status-and-the-risk-of-falls-in-women-the-rac-ost-pol-study
#10
Wojciech Rokicki, Bogna Drozdzowska, Aleksandra Czekajło, Władysław Grzeszczak, Katarzyna Wiktor, Wojciech Majewski, Wojciech Pluskiewicz
INTRODUCTION: Falls in elderly women producing fractures are a public health problem that could be largely preventable. The aim of this study was to determine the effect of visual impairment on functional status, falls and fractures in women. MATERIAL AND METHODS: We examined 623 women aged ≥ 55 years in order to assess the association between visual status and functional status and the risk of falls and fractures. Distance, near visual acuity, and depth perception were examined...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27904257/expression-of-p38-mitogen-activated-protein-kinases-glycogen-synthase-kinase-c-jun-nh2-terminal-kinase-extracellular-signal-regulated-kinase-signaling-can-it-be-used-as-molecular-markers-among-trauma-hemorrhagic-shock-patients
#11
Manoj Kumar, Keshava Sharma, Sanjeev Bhoi, Mahendra Kumar, Manjunath Maruti Pol
No abstract text is available yet for this article.
October 2016: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/27903797/accumulation-of-pol-mutations-selected-by-hla-b-52-01-c-12-02-protective-haplotype-restricted-ctls-causes-low-plasma-viral-load-due-to-low-viral-fitness-of-mutant-viruses
#12
Hayato Murakoshi, Madoka Koyanagi, Takayuki Chikata, Mohammad Arif Rahman, Nozomi Kuse, Keiko Sakai, Hiroyuki Gatanaga, Shinichi Oka, Masafumi Takiguchi
: HLA-B*52:01-C*12:02, which is the most abundant haplotype in Japan, has a protective effect on disease progression in HIV-1-infected Japanese individuals, whereas HLA-B*57 and -B*27 protective alleles are very rare in Japan. A previous study on HLA-associated polymorphisms demonstrated that the number of HLA-B*52:01-associated mutations at four Pol positions was inversely correlated with plasma viral load (pVL) in HLA-B*52:01-negative individuals, suggesting that the transmission of HIV-1 with these mutations could modulate the pVL in the population...
November 30, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27899035/delayed-seroconversion-to-htlv-ii-is-associated-with-a-stop-codon-mutation-in-the-pol-gene
#13
Syamalima Dube, Dipak K Dube, Lynn Abbott, Jordan Glaser, Bernard Poiesz
A known HIV-1 positive intravenous drug user was found to be HTLV-II DNA positive by PCR but seronegative in a screening ELISA assay. He was consistently DNA positive but took two years to fully seroconvert. Sequencing of the HTLV-II strain in his cultured T-lymphocytes indicated that it is a prototypical type A strain with no major differences in the LTR DNA sequence, nor major amino acid differences in the Gag, Env, Tax and Rex proteins. However, a mutation in its pol gene created a stop codon at amino acid 543 of the Pol protein, a region which encodes for the RNase function...
November 29, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27898567/utilization-of-the-cepheid-xpert%C3%A2-ct-ng-sample-adequacy-control-to-determine-the-influence-of-the-urethral-swab-on-cellular-content-in-post-swab-versus-pre-swab-urine
#14
Stephen J Jordan, Barbara Van Der Pol, Edward W Hook
Chlamydia trachomatis/Neisseria gonorrhoeae assay performance in males is typically determined using post-swab urine, though pre-swab urine is used in practice. We collected swabs and urine from men and used the Cepheid Xpert® CT/NG sample adequacy control to determine the effect of swab collection on urine cellular content. No difference was observed.
November 28, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27897226/viral-and-host-characteristics-of-recent-and-established-hiv-1-infections-in-kisumu-based-on-a-multiassay-approach
#15
Newton Otecko, Seth Inzaule, Collins Odhiambo, George Otieno, Valarie Opollo, Alex Morwabe, Kennedy Were, Kenneth Ndiege, Fredrick Otieno, Andrea A Kim, Clement Zeh
Integrated approaches provide better understanding of HIV/AIDS epidemics. We optimised a multiassay algorithm (MAA) and assessed HIV incidence, correlates of recent infections, viral diversity, plus transmission clusters among participants screened for Kisumu Incidence Cohort Study (KICoS1) (2007-2009). We performed BED-CEIA, Limiting antigen (LAg) avidity, Biorad avidity, and viral load (VL) tests on HIV-positive samples. Genotypic analyses focused on HIV-1 pol gene. Correlates of testing recent by MAA were assessed using logistic regression model...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896366/allelism-analysis-of-brrfp-locus-in-different-restorer-lines-and-map-based-cloning-of-a-fertility-restorer-gene-brrfp1-for-pol-cms-in-chinese-cabbage-brassica-rapa-l
#16
Huamin Zhang, Junqing Wu, Zihui Dai, Meiling Qin, Lingyu Hao, Yanjing Ren, Qingfei Li, Lugang Zhang
In Chinese cabbage, there are two Rf loci for pol CMS and one of them was mapped to a 12.6-kb region containing a potential candidate gene encoding PPR protein. In Chinese cabbage (Brassica rapa), polima cytoplasmic male sterility (pol CMS) is an important CMS type and is widely used for hybrid breeding. By extensive test crossing in Chinese cabbage, four restorer lines (92s105, 01s325, 00s109, and 88s148) for pol CMS were screened. By analyzing the allelism of the four restorer lines, it was found that 92s105, 01s325, and 00s109 had the same "restorers of fertility" (Rf) locus (designated as BrRfp1), but 88s148 had a different Rf locus (designated as BrRfp2)...
November 28, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27894862/hiv-drug-resistance-testing-among-patients-failing-second-line-antiretroviral-therapy-comparison-of-in-house-and-commercial-sequencing
#17
Benjamin Chimukangara, Bhavini Varyani, Tinei Shamu, Junior Mutsvangwa, Justen Manasa, Elizabeth White, Cleophas Chimbetete, Ruedi Luethy, David Katzenstein
INTRODUCTION: HIV genotyping is often unavailable in low and middle-income countries due to infrastructure requirements and cost. We compared genotype resistance testing in patients with virologic failure, by amplification of HIV pol gene, followed by "in-house" sequencing and commercial sequencing. METHODS: Remnant plasma samples from adults and children failing second-line ART were amplified and sequenced using in-house and commercial di-deoxysequencing, and analyzed in Harare, Zimbabwe and at Stanford, U...
November 25, 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27893852/a-comparative-study-of-smn-protein-and-mrna-in-blood-and-fibroblasts-in-patients-with-spinal-muscular-atrophy-and-healthy-controls
#18
Renske I Wadman, Marloes Stam, Marc D Jansen, Yana van der Weegen, Camiel A Wijngaarde, Oliver Harschnitz, Peter Sodaar, Kees P J Braun, Dennis Dooijes, Henny H Lemmink, Leonard H van den Berg, W Ludo van der Pol
BACKGROUND: Clinical trials to test safety and efficacy of drugs for patients with spinal muscular atrophy (SMA) are currently underway. Biomarkers that document treatment-induced effects are needed because disease progression in childhood forms of SMA is slow and clinical outcome measures may lack sensitivity to detect meaningful changes in motor function in the period of 1-2 years of follow-up during randomized clinical trials. OBJECTIVE: To determine and compare SMN protein and mRNA levels in two cell types (i...
2016: PloS One
https://www.readbyqxmd.com/read/27893601/reducing-missed-opportunities-pairing-sexually-transmitted-infection-screening-with-syringe-exchange-services
#19
Alexis M Roth, Jesse L Goldshear, Ana P Martinez-Donate, Seth Welles, Martha Chavis, Barbara Van Der Pol
About 17.5% of sexually active injection drug users recruited from a syringe exchange in Camden, NJ (n = 120) screened positive for chlamydia/gonorrhea. Among these cases, 40% were detected via extragenital screening. This pilot demonstrates that colocating sexually transmitted infection control with syringe exchange leads to sexually transmitted infection case finding.
November 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27890617/polycistronic-trna-and-crispr-guide-rna-enables-highly-efficient-multiplexed-genome-engineering-in-human-cells
#20
Fengping Dong, Kabin Xie, Yueying Chen, Yinong Yang, Yingwei Mao
CRISPR/Cas9 has been widely used for genomic editing in many organisms. Many human diseases are caused by multiple mutations. The CRISPR/Cas9 system provides a potential tool to introduce multiple mutations in a genome. To mimic complicated genomic events in human diseases, such as multiple gene deletions or mutations, two or more small guide RNAs (sgRNA) must be introduced all together. This can be achieved by separate Pol III promoters in a construct. However, limited enzyme sites and the increased insertion size lower the efficiency to make a construct...
November 24, 2016: Biochemical and Biophysical Research Communications
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