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https://www.readbyqxmd.com/read/28079339/survey-of-bullous-pemphigoid-in-an-italian-university-hospital-clinical-epidemiological-characteristics-and-follow-up
#1
Riccardo Balestri, Giulia Odorici, Annalisa Patrizi, Salvatore D Infusino, Michela Magnano, Federico Bardazzi
BACKGROUND: The clinical-epidemiological characteristics and course of bullous pemphigoid in the general population is not clear. Few studies have been performed to date, and only one in the Italian population more than ten years ago. We decided to evaluate the characteristics and outcome of patients admitted for a bullous pemphigoid at our Hospital in the last 4 years. METHODS: We retrospectively review the last 4 years' medical records of the Department of Dermatology of the University of Bologna, identifying all patients with histological and immunological data typical for bullous pemphigoid...
January 12, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28036140/european-guidelines-s1-on-the-use-of-high-dose-intravenous-immunoglobulin-in-dermatology
#2
Alexander Enk, Eva Hadaschik, Rüdiger Eming, Gerhard Fierlbeck, Lars French, Giampiero Girolomoni, Michael Hertl, Stephen Jolles, Sarolta Karpati, Kerstin Steinbrink, Georg Stingl, Beatrix Volc-Platzer, Detlef Zillikens
BACKGROUND AND OBJECTIVES: Treatment of severe dermatological autoimmune diseases and toxic epidermal necrolysis (TEN) with high-dose intravenous immunoglobulin (IVIg) is a well-established procedure in dermatology. As treatment with IVIg is usually considered for rare clinical entities or severe cases, the use of immunoglobulin is not generally based on data from randomized controlled trials usually required for evidence-based medicine. Since the indications for the use of IVIg are rare, it is unlikely that such studies will be available in the foreseeable future...
December 30, 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28032352/patch-testing-with-rubber-series-in-europe-a-critical-review-and-recommendation
#3
Katharine L Warburton, Wolfgang Uter, Johannes Geier, Radoslaw Spiewak, Vera Mahler, Marie-Noëlle Crépy, Marie-Louise Schuttelaar, Andrea Bauer, Mark Wilkinson
BACKGROUND: Rubber additives constitute an important group of contact allergens, particularly in certain occupations. OBJECTIVES: To collect information regarding the current practice of using a 'rubber series' in Europe, and discuss this against the background of evidence concerning the prevalence of allergy in order to derive a recommendation for a 'European rubber series'. METHODS: The following were performed: (i) a survey targeting all members of the COST action 'StanDerm' consortium, (ii) analysis of rubber contact allergy data in the database of the European Surveillance System on Contact Allergies, and (iii) a literature review...
December 28, 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/28027199/the-combination-of-resveratrol-and-high-fluence-light-emitting-diode-red-light-produces-synergistic-photobotanical-inhibition-of-fibroblast-proliferation-and-collagen-synthesis-a-novel-treatment-for-skin-fibrosis
#4
Andrew Mamalis, Jared Jagdeo
BACKGROUND: Skin fibrosis is a debilitating condition that significantly impacts patient quality of life. Ultraviolet phototherapy is currently used to treat several diseases featuring skin fibrosis. High-fluence light-emitting diode-generated red light (HF-LED-RL) does not cause DNA damage associated with skin cancer, and it is generally regarded as safe, portable, and cost-effective. Early clinical observations suggest that LED-generated light may possess antifibrotic effects, although these findings are largely unexplored...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28011162/effect-of-st-john-s-wort-hypericum-perforatum-oily-extract-for-the-care-and-treatment-of-pressure-sores-a-case-report
#5
Ali Yücel, Yüksel Kan, Erdem Yesilada, Onat Akın
ETHNOPHARMACOLOGICAL RELEVANCE: Topical formulations such as oily extracts or ointments prepared with the flowering aerial parts of St. John's wort (Hypericum perforatum L., Hypericaceae) have been used in the management of a wide range dermatological problems including superficial wounds and burns, bruises, contusions and many others in the worldwide traditional medicines. AIM OF THE STUDY: This is the first case study reporting the beneficial effects of an oily extract of St...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27995624/diagnosing-liver-fibrosis-a-narrative-review-of-current-literature-for-dermatologists
#6
REVIEW
J R Potts, C M Maybury, A Salam, J N Barker, K Agarwal, C H Smith
Chronic liver disease is a growing problem worldwide due to obesity, alcohol-related liver disease and viral hepatitis. Liver fibrosis is generally asymptomatic and patients may not present until they have advanced cirrhosis, when the scope for reversibility is limited. Identification of asymptomatic individuals at an early stage, is fundamental to reversing the rising toll of liver-related morbidity and mortality. Awareness of liver disease and the techniques for diagnosis is important for dermatologists, not only due to the burden of disease in the general population but also because some dermatology cohorts may have an elevated risk; for example the increased prevalence of metabolic syndrome and excess alcohol use in those with psoriasis and hidradenitis suppurativa, in addition to the use of potentially hepatotoxic drugs such as methotrexate...
December 20, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27913776/necitumumab-for-the-treatment-of-squamous-cell-non-small-cell-lung-cancer
#7
Jessica K Brinkmeyer, Donald C Moore
Non-small cell lung cancer is the most common form of lung cancer, accounting for about 85% of all cases and is further subdivided into adenocarcinoma, squamous cell, and large cell carcinoma. Necitumumab (Portrazza™, Eli Lilly and Company) is an anti-epidermal growth factor receptor monoclonal antibody approved for the first-line treatment of squamous cell non-small cell lung cancer in combination with cisplatin and gemcitabine. The safety and efficacy of necitumumab has been evaluated in two-phase III clinical trials, one demonstrating a lack of efficacy in non-squamous non-small cell lung cancer and another demonstrating improvement in overall survival and progression-free survival in squamous cell non-small cell lung cancer...
December 2, 2016: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/27847548/needlestick-and-sharps-injuries-in-dermatologic-surgery-a-review-of-preventative-techniques-and-post-exposure-protocols
#8
REVIEW
Christopher Rizk, Holly Monroe, Ida Orengo, Theodore Rosen
Background: Needlestickand sharps injuries are the leading causes of morbidity in the dermatologicfield. Among medical specialties, surgeons and dermatologists have the highest rates of needlestickand sharps injuries.The high rates of needlestickand sharps injuries in dermatology not only apply to physicians, but also to nurses, physician assistants, and technicians in the demnatologic field. Needlestickand sharps injuries are of great concern due to the monetary, opportunity, social, and emotional costs associated with their occurrence...
October 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27822110/the-danish-nonmelanoma-skin-cancer-dermatology-database
#9
REVIEW
Anna Lei Lamberg, Henrik Sølvsten, Ulrikke Lei, Gabrielle Randskov Vinding, Ida Marie Stender, Gregor Borut Ernst Jemec, Tine Vestergaard, Henrik Thormann, Merete Hædersdal, Tomas Norman Dam, Anne Braae Olesen
AIM OF DATABASE: The Danish Nonmelanoma Skin Cancer Dermatology Database was established in 2008. The aim of this database was to collect data on nonmelanoma skin cancer (NMSC) treatment and improve its treatment in Denmark. NMSC is the most common malignancy in the western countries and represents a significant challenge in terms of public health management and health care costs. However, high-quality epidemiological and treatment data on NMSC are sparse. STUDY POPULATION: The NMSC database includes patients with the following skin tumors: basal cell carcinoma (BCC), squamous cell carcinoma, Bowen's disease, and keratoacanthoma diagnosed by the participating office-based dermatologists in Denmark...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27803721/quality-of-life-evaluation-in-iranian-postpartum-women-with-and-without-striae-gravidarum
#10
Masoumeh Kordi, Farzaneh Rashidi Fakari, Seyed Reza Mazloum, Pouran Layegh
BACKGROUND: Striae are a common change during pregnancy, leaving striae in various body parts after delivery, which most women find unpleasant. They create a big aesthetic concern for most women. Although striae do not endanger the mother and the fetus, they may cause a desire to scratch the region leading to small wounds, induce stress over beauty, decrease self-confidence, and create psychological disorders. They may try various treatments and often refer to dermatology clinics and receive long-term treatments; these time-consuming and costly behaviors and may affect their quality of life...
June 2016: Iranian Journal of Psychiatry and Behavioral Sciences
https://www.readbyqxmd.com/read/27785771/pharmacoeconomic-considerations-in-treating-actinic-keratosis-an-update
#11
REVIEW
Spencer M Vale, Dane Hill, Steven R Feldman
Actinic keratosis is one of the most common dermatological diagnoses worldwide, especially among the elderly, fair-skinned, and immunocompromised, and is associated with a risk of transformation to skin cancer. With actinic keratosis and skin cancer prevalence increasing as the aged population expands in the US, optimizing treatment strategies may produce cost savings for the healthcare system. Since the time of our last review in 2008, investigation of the economic considerations in treating actinic keratosis has advanced...
October 27, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27768177/addressing-practice-gaps-in-cutaneous-surgery-advances-in-diagnosis-and-treatment
#12
Kathryn L Kreicher, Jeremy S Bordeaux
Importance: Cutaneous surgery is performed by otolaryngologists, plastic surgeons, oculoplastic surgeons, dermatologic surgeons, and some primary care physicians. Practice gaps exist among cutaneous surgeons, as do differences in how different physicians approach preoperative, intraoperative, and postoperative decision-making. Objective: To present the newest and best evidence to close common practice gaps in cutaneous surgery. Evidence Review: We performed a detailed search of peer-reviewed publications that were identified through a search of PubMed/MEDLINE (January 1, 2000, through June 30, 2016) using the literature search terms "cutaneous surgery," "Mohs micrographic surgery," "plastic surgery," in combination with "safety," "cost," "anesthesia," "anti-coagulation," "bleeding," "pain," "analgesia," "anxiety," or "infection," among others...
October 20, 2016: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/27761268/promising-new-wart-treatment-a-randomized-placebo-controlled-clinical-trial
#13
Shokrollah Zandi, Razyeh Ahmad Zadeh, Sayedeh Reyhaneh Yousefi, Fardin Gharibi
BACKGROUND: Warts are common dermatological lesion caused by skin epithelial cells' infection with human Papillomavirus (HPV). OBJECTIVES: This study aimed to assess the efficacy of a new method for the treatment of dermal warts. PATIENTS AND METHODS: In this clinical trial study, 60 patients (older than 10 years) with dermal warts living in Baneh city, west of Iran, were allocated into the intervention and control groups using the block randomized method in 2012...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27741336/bensal-hp-for-second-intention-healing-following-mohs-micrographic-surgery-or-shave-skin-biopsy-an-open-label-pilot-study
#14
Breanne Mordorski, Adam J Friedman, Leon H Kircik
Dermatologists frequently create cutaneous defects that heal by second intention, yet there is no universal protocol for wound care in this setting. Several ointments commonly used for wound healing are not cost effective as they contain known contact allergens, contribute to antimicrobial resistance, and do not enhance the healing process. Recent studies indicate that Bensal HP, a commercially available ointment used for a variety of dermatologic conditions, may be useful for wound healing; although clinical data is currently limited...
October 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27707589/future-considerations-for-clinical-dermatology-in-the-setting-of-21st-century-american-policy-reform-accountable-care-organizations
#15
Harrison P Nguyen, John S Barbieri, Howard P Forman, Jean L Bolognia, Marta J VanBeek
An Accountable Care Organization (ACO) is a network of providers that collaborates to manage care and is financially incentivized to realize cost savings while also optimizing standards of care. Since its introduction as part of the 2010 Patient Protection and Affordable Care Act, ACOs have grown to include 16% of Medicare beneficiaries and currently represent Medicare's largest payment initiative. Although ACOs are still in the pilot phase with multiple structural models being assessed, incentives are being introduced to encourage specialist participation, and dermatologists will have the opportunity to influence both the cost savings and quality standard aspects of these organizations...
January 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27706019/antidermatophytic-action-of-resorcinol-derivatives-ultrastructural-evidence-of-the-activity-of-phenylethyl-resorcinol-against-microsporum-gypseum
#16
Carlo Romagnoli, Anna Baldisserotto, Chiara B Vicentini, Donatella Mares, Elisa Andreotti, Silvia Vertuani, Stefano Manfredini
In this work, we evaluated the antidermatophytic activities of three resorcinol derivatives that have a history of use in dermo-cosmetic applications to discover molecules with multiple dermatological activities (i.e., multi-target drugs), thereby reducing the cost and time necessary for new drug development. The antidermatophytic activities of the three skin lighteners were evaluated relative to the known antifungal drug fluconazole on nine dermatophytes responsible for the most common dermatomycoses: Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Arthroderma cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Nannizzia gypsea, Trichophyton rubrum and Trichophyton tonsurans...
September 30, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27692444/basics-of-confocal-microscopy-and-the-complexity-of-diagnosing-skin%C3%A2-tumors-new-imaging-tools-in-clinical-practice-diagnostic-workflows-cost-estimate-and%C3%A2-new-trends
#17
REVIEW
Syril Keena T Que, Jane M Grant-Kels, Caterina Longo, Giovanni Pellacani
The use of reflectance confocal microscopy (RCM) and other noninvasive imaging devices can potentially streamline clinical care, leading to more precise and efficient management of skin cancer. This article explores the potential role of RCM in cutaneous oncology, as an adjunct to more established techniques of detecting and monitoring for skin cancer, such as dermoscopy and total body photography. Discussed are current barriers to the adoption of RCM, diagnostic workflows and standards of care in the United States and Europe, and medicolegal issues...
October 2016: Dermatologic Clinics
https://www.readbyqxmd.com/read/27690471/clinical-practice-guideline-for-diagnosis-and-management-of-urticaria
#18
Kanokvalai Kulthanan, Papapit Tuchinda, Leena Chularojanamontri, Pattriya Chanyachailert, Wiwat Korkij, Amornsri Chunharas, Siriwan Wananukul, Wanida Limpongsanurak, Suwat Benjaponpitak, Wanee Wisuthsarewong, Kobkul Aunhachoke, Vesarat Wessagowit, Pantipa Chatchatee, Penpun Wattanakrai, Orathai Jirapongsananuruk, Jettanong Klaewsongkram, Nopadon Noppakun, Pakit Vichyanond, Puan Suthipinittharm, Kiat Ruxrungtham, Srisupalak Singalavanija, Jarungchit Ngamphaiboon
Urticaria is a common skin condition that can compromise quality of life and may affect individual performance at work or school. Remission is common in majority of patients with acute spontaneous urticaria (ASU); however, in chronic cases, less than 50% had remission. Angioedema either alone or with urticaria is associated with a much lower remission rate. Proper investigation and treatment is thus required. This guideline, a joint development of the Dermatological Society of Thailand, the Allergy, Asthma, and Immunology Association of Thailand and the Pediatric Dermatological Society of Thailand, is graded and recommended based on published evidence and expert opinion...
September 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/27650169/spinal-cord-injury-suppresses-cutaneous-inflammation-implications-for-peripheral-wound-healing
#19
Jessica M Marbourg, Anna Bratasz, Xiaokui Mo, Phillip G Popovich
People who suffer a traumatic spinal cord injury (SCI) are at increased risk for developing dermatological complications. These conditions increase cost of care, incidence of rehospitalization, and the risk for developing other infections. The consequences of dermatological complications after SCI are likely exacerbated further by post-injury deficits in neural-immune signaling. Indeed, a functional immune system is essential for optimal host defense and tissue repair. Here, we tested the hypothesis that SCI at high spinal levels, which causes systemic immune suppression, would suppress cutaneous inflammation below the level of injury...
October 17, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27637487/impact-of-measuring-patient-reported-outcomes-in-dermatology-drug-development
#20
Catherine Copley-Merriman, Susan Zelt, Marci Clark, Ari Gnanasakthy
Although some symptoms of dermatologic diseases, such as pruritus and pain, can be subjectively assessed only by patients, the most commonly used endpoints in dermatology drug research traditionally have been clinician-reported outcomes. Research has found that patient-reported outcomes (PROs) were included in only one-quarter of 125 trials conducted between 1994 and 2001. Our objective was to characterize the impact of PROs in dermatology drug development from the patient, prescriber, regulator, payer, and manufacturer perspectives using a case study approach...
September 15, 2016: Patient
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