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https://www.readbyqxmd.com/read/27913776/necitumumab-for-the-treatment-of-squamous-cell-non-small-cell-lung-cancer
#1
Jessica K Brinkmeyer, Donald C Moore
Non-small cell lung cancer is the most common form of lung cancer, accounting for about 85% of all cases and is further subdivided into adenocarcinoma, squamous cell, and large cell carcinoma. Necitumumab (Portrazza™, Eli Lilly and Company) is an anti-epidermal growth factor receptor monoclonal antibody approved for the first-line treatment of squamous cell non-small cell lung cancer in combination with cisplatin and gemcitabine. The safety and efficacy of necitumumab has been evaluated in two-phase III clinical trials, one demonstrating a lack of efficacy in non-squamous non-small cell lung cancer and another demonstrating improvement in overall survival and progression-free survival in squamous cell non-small cell lung cancer...
December 2, 2016: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/27847548/needlestick-and-sharps-injuries-in-dermatologic-surgery-a-review-of-preventative-techniques-and-post-exposure-protocols
#2
REVIEW
Christopher Rizk, Holly Monroe, Ida Orengo, Theodore Rosen
Background: Needlestickand sharps injuries are the leading causes of morbidity in the dermatologicfield. Among medical specialties, surgeons and dermatologists have the highest rates of needlestickand sharps injuries.The high rates of needlestickand sharps injuries in dermatology not only apply to physicians, but also to nurses, physician assistants, and technicians in the demnatologic field. Needlestickand sharps injuries are of great concern due to the monetary, opportunity, social, and emotional costs associated with their occurrence...
October 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27822110/the-danish-nonmelanoma-skin-cancer-dermatology-database
#3
REVIEW
Anna Lei Lamberg, Henrik Sølvsten, Ulrikke Lei, Gabrielle Randskov Vinding, Ida Marie Stender, Gregor Borut Ernst Jemec, Tine Vestergaard, Henrik Thormann, Merete Hædersdal, Tomas Norman Dam, Anne Braae Olesen
AIM OF DATABASE: The Danish Nonmelanoma Skin Cancer Dermatology Database was established in 2008. The aim of this database was to collect data on nonmelanoma skin cancer (NMSC) treatment and improve its treatment in Denmark. NMSC is the most common malignancy in the western countries and represents a significant challenge in terms of public health management and health care costs. However, high-quality epidemiological and treatment data on NMSC are sparse. STUDY POPULATION: The NMSC database includes patients with the following skin tumors: basal cell carcinoma (BCC), squamous cell carcinoma, Bowen's disease, and keratoacanthoma diagnosed by the participating office-based dermatologists in Denmark...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27803721/quality-of-life-evaluation-in-iranian-postpartum-women-with-and-without-striae-gravidarum
#4
Masoumeh Kordi, Farzaneh Rashidi Fakari, Seyed Reza Mazloum, Pouran Layegh
BACKGROUND: Striae are a common change during pregnancy, leaving striae in various body parts after delivery, which most women find unpleasant. They create a big aesthetic concern for most women. Although striae do not endanger the mother and the fetus, they may cause a desire to scratch the region leading to small wounds, induce stress over beauty, decrease self-confidence, and create psychological disorders. They may try various treatments and often refer to dermatology clinics and receive long-term treatments; these time-consuming and costly behaviors and may affect their quality of life...
June 2016: Iranian Journal of Psychiatry and Behavioral Sciences
https://www.readbyqxmd.com/read/27785771/pharmacoeconomic-considerations-in-treating-actinic-keratosis-an-update
#5
REVIEW
Spencer M Vale, Dane Hill, Steven R Feldman
Actinic keratosis is one of the most common dermatological diagnoses worldwide, especially among the elderly, fair-skinned, and immunocompromised, and is associated with a risk of transformation to skin cancer. With actinic keratosis and skin cancer prevalence increasing as the aged population expands in the US, optimizing treatment strategies may produce cost savings for the healthcare system. Since the time of our last review in 2008, investigation of the economic considerations in treating actinic keratosis has advanced...
October 27, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27768177/addressing-practice-gaps-in-cutaneous-surgery-advances-in-diagnosis-and-treatment
#6
Kathryn L Kreicher, Jeremy S Bordeaux
Importance: Cutaneous surgery is performed by otolaryngologists, plastic surgeons, oculoplastic surgeons, dermatologic surgeons, and some primary care physicians. Practice gaps exist among cutaneous surgeons, as do differences in how different physicians approach preoperative, intraoperative, and postoperative decision-making. Objective: To present the newest and best evidence to close common practice gaps in cutaneous surgery. Evidence Review: We performed a detailed search of peer-reviewed publications that were identified through a search of PubMed/MEDLINE (January 1, 2000, through June 30, 2016) using the literature search terms "cutaneous surgery," "Mohs micrographic surgery," "plastic surgery," in combination with "safety," "cost," "anesthesia," "anti-coagulation," "bleeding," "pain," "analgesia," "anxiety," or "infection," among others...
October 20, 2016: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/27761268/promising-new-wart-treatment-a-randomized-placebo-controlled-clinical-trial
#7
Shokrollah Zandi, Razyeh Ahmad Zadeh, Sayedeh Reyhaneh Yousefi, Fardin Gharibi
BACKGROUND: Warts are common dermatological lesion caused by skin epithelial cells' infection with human Papillomavirus (HPV). OBJECTIVES: This study aimed to assess the efficacy of a new method for the treatment of dermal warts. PATIENTS AND METHODS: In this clinical trial study, 60 patients (older than 10 years) with dermal warts living in Baneh city, west of Iran, were allocated into the intervention and control groups using the block randomized method in 2012...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27741336/bensal-hp-for-second-intention-healing-following-mohs-micrographic-surgery-or-shave-skin-biopsy-an-open-label-pilot-study
#8
Breanne Mordorski, Adam J Friedman, Leon H Kircik
Dermatologists frequently create cutaneous defects that heal by second intention, yet there is no universal protocol for wound care in this setting. Several ointments commonly used for wound healing are not cost effective as they contain known contact allergens, contribute to antimicrobial resistance, and do not enhance the healing process. Recent studies indicate that Bensal HP, a commercially available ointment used for a variety of dermatologic conditions, may be useful for wound healing; although clinical data is currently limited...
October 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27707589/future-considerations-for-clinical-dermatology-in-the-setting-of-21st-century-american-policy-reform-accountable-care-organizations
#9
Harrison P Nguyen, John S Barbieri, Howard P Forman, Jean L Bolognia, Marta J VanBeek
An Accountable Care Organization (ACO) is a network of providers that collaborates to manage care and is financially incentivized to realize cost savings while also optimizing standards of care. Since its introduction as part of the 2010 Patient Protection and Affordable Care Act, ACOs have grown to include 16% of Medicare beneficiaries and currently represent Medicare's largest payment initiative. Although ACOs are still in the pilot phase with multiple structural models being assessed, incentives are being introduced to encourage specialist participation, and dermatologists will have the opportunity to influence both the cost savings and quality standard aspects of these organizations...
October 1, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27706019/antidermatophytic-action-of-resorcinol-derivatives-ultrastructural-evidence-of-the-activity-of-phenylethyl-resorcinol-against-microsporum-gypseum
#10
Carlo Romagnoli, Anna Baldisserotto, Chiara B Vicentini, Donatella Mares, Elisa Andreotti, Silvia Vertuani, Stefano Manfredini
In this work, we evaluated the antidermatophytic activities of three resorcinol derivatives that have a history of use in dermo-cosmetic applications to discover molecules with multiple dermatological activities (i.e., multi-target drugs), thereby reducing the cost and time necessary for new drug development. The antidermatophytic activities of the three skin lighteners were evaluated relative to the known antifungal drug fluconazole on nine dermatophytes responsible for the most common dermatomycoses: Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Arthroderma cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Nannizzia gypsea, Trichophyton rubrum and Trichophyton tonsurans...
September 30, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27692444/basics-of-confocal-microscopy-and-the-complexity-of-diagnosing-skin%C3%A2-tumors-new-imaging-tools-in-clinical-practice-diagnostic-workflows-cost-estimate-and%C3%A2-new-trends
#11
Syril Keena T Que, Jane M Grant-Kels, Caterina Longo, Giovanni Pellacani
The use of reflectance confocal microscopy (RCM) and other noninvasive imaging devices can potentially streamline clinical care, leading to more precise and efficient management of skin cancer. This article explores the potential role of RCM in cutaneous oncology, as an adjunct to more established techniques of detecting and monitoring for skin cancer, such as dermoscopy and total body photography. Discussed are current barriers to the adoption of RCM, diagnostic workflows and standards of care in the United States and Europe, and medicolegal issues...
October 2016: Dermatologic Clinics
https://www.readbyqxmd.com/read/27690471/clinical-practice-guideline-for-diagnosis-and-management-of-urticaria
#12
Kanokvalai Kulthanan, Papapit Tuchinda, Leena Chularojanamontri, Pattriya Chanyachailert, Wiwat Korkij, Amornsri Chunharas, Siriwan Wananukul, Wanida Limpongsanurak, Suwat Benjaponpitak, Wanee Wisuthsarewong, Kobkul Aunhachoke, Vesarat Wessagowit, Pantipa Chatchatee, Penpun Wattanakrai, Orathai Jirapongsananuruk, Jettanong Klaewsongkram, Nopadon Noppakun, Pakit Vichyanond, Puan Suthipinittharm, Kiat Ruxrungtham, Srisupalak Singalavanija, Jarungchit Ngamphaiboon
Urticaria is a common skin condition that can compromise quality of life and may affect individual performance at work or school. Remission is common in majority of patients with acute spontaneous urticaria (ASU); however, in chronic cases, less than 50% had remission. Angioedema either alone or with urticaria is associated with a much lower remission rate. Proper investigation and treatment is thus required. This guideline, a joint development of the Dermatological Society of Thailand, the Allergy, Asthma, and Immunology Association of Thailand and the Pediatric Dermatological Society of Thailand, is graded and recommended based on published evidence and expert opinion...
September 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/27650169/spinal-cord-injury-suppresses-cutaneous-inflammation-implications-for-peripheral-wound-healing
#13
Jessica M Marbourg, Anna Bratasz, Xiaokui Mo, Phillip G Popovich
People who suffer a traumatic spinal cord injury (SCI) are at increased risk for developing dermatological complications. These conditions increase cost of care, incidence of rehospitalization, and the risk for developing other infections. The consequences of dermatological complications after SCI are likely exacerbated further by post-injury deficits in neural-immune signaling. Indeed, a functional immune system is essential for optimal host defense and tissue repair. Here, we tested the hypothesis that SCI at high spinal levels, which causes systemic immune suppression, would suppress cutaneous inflammation below the level of injury...
October 17, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27637487/impact-of-measuring-patient-reported-outcomes-in-dermatology-drug-development
#14
Catherine Copley-Merriman, Susan Zelt, Marci Clark, Ari Gnanasakthy
Although some symptoms of dermatologic diseases, such as pruritus and pain, can be subjectively assessed only by patients, the most commonly used endpoints in dermatology drug research traditionally have been clinician-reported outcomes. Research has found that patient-reported outcomes (PROs) were included in only one-quarter of 125 trials conducted between 1994 and 2001. Our objective was to characterize the impact of PROs in dermatology drug development from the patient, prescriber, regulator, payer, and manufacturer perspectives using a case study approach...
September 15, 2016: Patient
https://www.readbyqxmd.com/read/27624921/a-popular-myth-low-histamine-diet-improves-chronic-spontaneous-urticaria-fact-or-fiction
#15
N Wagner, D Dirk, A Peveling-Oberhag, I Reese, U Rady-Pizarro, H Mitzel, P Staubach
BACKGROUND: Chronic spontaneous urticaria (CsU) is a frequent dermatological disease that might last for months or years with high impact on quality of life. Known causes are autoreactive phenomena, infections or intolerances, rarely IgE-mediated allergies. One-third of CsU patients benefit from a low-pseudoallergen diet. Additionally, it is often discussed, that reducing histamine ingestion alone might improve clinical symptoms and quality of life in CsU patients despite the uncertain role of the histamine-degrading enzyme diamine oxidase (DAO)...
September 13, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27599660/bullous-impetigo-rapid-diagnostic-and-therapeutic-quiz-a-model-for-assessing-basic-dermatology-knowledge-of-primary-care-providers
#16
Daren J Simkin, Anna L Grossberg, Bernard A Cohen
BACKGROUND/OBJECTIVES: Bullous impetigo (BI) is a common dermatologic condition, particularly in children, yet confusion regarding its diagnosis and treatment persists. This study measured pediatricians' ability to diagnose and appropriately treat BI and explored factors that might influence pediatricians' accuracy in managing BI. METHODS: We administered an expert-validated survey to 64 pediatrics house staff and faculty at three Johns Hopkins Medicine facilities...
September 7, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27599656/treatment-satisfaction-willingness-to-pay-and-quality-of-life-in-japanese-patients-with-psoriasis
#17
Saori Masaki, Ryoko Tatsukawa, Miki Uryu, Masakazu Takahara, Masutaka Furue, Chika Ohata, Takekuni Nakama, Ryosuke Hino, Motonobu Nakamura, Juichiro Nakayama, Shinichi Imafuku
There is a range of psoriasis treatments available, from topical applications to biologic therapy, with corresponding cost variations. The efficacy of each treatment is usually evaluated by objective measures such as the Psoriasis Area and Severity Index (PASI) or subjective measures such as the Dermatology Life Quality Index (DLQI). However, the social and economic impacts of psoriasis, including cost-effectiveness, have not been assessed in Japan. The EuroQol 5-Dimension (EQ-5D) is a generic instrument used worldwide to calculate quality-adjusted life years, on which calculations of treatment cost-effectiveness are based...
September 7, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27594551/treatment-adherence-and-beliefs-about-medicines-among-egyptian-vitiligo-patients
#18
Mostafa A Sayed Ali, Doaa A E Abou-Taleb, Refaat Ragheb Mohamed
: Vitiligo is a chronic disorder of depigmentation that has different treatment modalities, but patients' nonadherence is common. This study aimed to assess the influence of patients' medication beliefs on patients' adherence to topical, oral medications, and phototherapy in vitiligo. Between September 2015 and February 2016, 260 patients with vitiligo were asked to fill in the Beliefs about Medicines Questionnaire (BMQ) to assess their beliefs about therapy for vitiligo. Their adherence to the therapy was examined using the 8-item Morisky Medication Adherence Scale (MMAS-8)...
September 4, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27579938/a-dermatological-questionnaire-for-general-practitioners-in-england-with-a-focus-on-melanoma-misdiagnosis-in-black-patients-compared-to-white-patients
#19
M Lyman, J O Mills, A R Shipman
BACKGROUND: Malignant melanoma presents a significant health burden in the UK in terms of mortality and financial cost. This aggressive and often fatal disease is under-diagnosed among patients with darker skin tones (type 5 and 6) such as Afro-Caribbean patients. A lack of both patient and practitioner awareness leads to a later diagnosis in patients with black compared to white skin. There is currently a paucity of literature looking at the diagnosis rates of melanoma between patients of different ethnicities in the UK and the reasons behind these differences...
August 31, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27544020/systematic-mapping-review-about-costs-and-economic-evaluations-of-skin-conditions-and-diseases-in-the-aged
#20
Andrea Lichterfeld-Kottner, Elisabeth Hahnel, Ulrike Blume-Peytavi, Jan Kottner
BACKGROUND: Skin conditions and dermatological diseases associated with advanced age (e.g. fungal infection, dry skin and itch) receive increasingly attention in clinical practice and research. Cost and economic evaluations are important sources to inform priority setting and ressource allocation decisions in healthcare. The economics of skin conditions in aged populations has not been systematically reviewed so far. OBJECTIVES: The aim of this mapping review was to summarize the economic evidence of selected skin conditions in the aged (65 + years)...
July 25, 2016: Journal of Tissue Viability
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