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Multiple intraluminal impedance

Nina Ristic, Ivan Milovanovic, Milica Radusinovic, Marija Stevic, Milos Ristic, Maja Ristic, Darija Kisic Tepavcevic, Tamara Alempijevic
OBJECTIVES: The aim of this study was to compare the different diagnostic approaches in detection of gastroesophageal reflux disease in children presented with symptoms suggesting gastroesophageal reflux disease. METHODS: The study design was cross sectional. The study retrospectively included all children who underwent combined multiple intraluminal impedance and pH (pH-MII) monitoring due to gastrointestinal and/or extraesophageal symptoms suggesting gastroesophageal reflux disease at University Children's Hospital in Belgrade, from July 2012 to July 2016...
2017: PloS One
Felicia Galos, Catalin Boboc, Mihaela Balgradean
The clinical manifestations of non-erosive gastroesophageal reflux disease (NERD) are multiple and heterogeneous, and differ according to age and individual susceptibility. Weakly acidic reflux and the presence of gas in the refluxate could be relevant in the pathogenesis of symptoms. We present the case of a 3-year and 5-month-old child who came to the hospital with recurrent paroxysmal manifestations without fever assessed. The positive diagnosis was made using pH-metry associated with multichannel intraluminal impedance and glucose respiratory breath test, a new technique that allows positive diagnosis as well as establishes important connections regarding gas reflux and clinical symptomatology described by the patient...
December 2016: Mædica
Ahmed Abdallah, Tarek El-Desoky, Khalid Fathi, Wagdi Fawzi Elkashef, Ahmed Zaki
BACKGROUND AND STUDY AIMS: Gastro-oesophageal reflux disease (GERD) is incriminated as a cause of non-asthmatic infantile wheeze. To date, no diagnostic test is considered standard for GERD-related airway reflux diagnosis. Oesophageal combined multiple channel intraluminal impedance and pH (MII-pH) monitoring is proposed to be a sensitive tool for evaluation of all GERD including infantile wheeze. We aimed to determine the GERD prevalence amongst wheezy infants in the first year of life using combined MII-pH versus pH monitoring alone and evaluate the sensitivity and specificity of objective MII-pH monitoring parameters in GERD-associated infantile wheeze diagnosis compared to those of lipid-laden macrophage index (LLMI)...
June 1, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
I Marin, D Cisternas, L Abrao, E Lemme, C Bilder, A Ditaranto, R Coello, A Hani, A M Leguizamo, A Meixueiro, J Remes-Troche, M A Zavala, A Ruiz de León, J Perez de la Serna, M A Valdovinos, J Serra
BACKGROUND: Multiple water swallow is increasingly used as a complementary challenge test in patients undergoing high-resolution manometry (HRM). Our aim was to establish the range of normal pressure responses during the rapid drink challenge test in a large population of healthy subjects. METHODS: Pressure responses to a rapid drink challenge test (100 or 200 mL of water) were prospectively analyzed in 105 healthy subjects studied in nine different hospitals from different countries...
June 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
S I Kim, O E Kwon, S Y Na, Y C Lee, J M Park, Y G Eun
OBJECTIVE: To evaluate the association between the parameters of 24-hour multichannel intraluminal impedance (MII)-pH monitoring and the symptoms or quality of life (QoL) in laryngopharyngeal reflux (LPR) patients. DESIGN: Prospective cohort study without controls. SETTING: University teaching hospital. METHODS: Forty-five LPR patients were selected from subjects who underwent 24-hour MII-pH monitoring and were diagnosed with LPR from September 2014 to May 2015...
June 2017: Clinical Otolaryngology
Judith Cohen Sabban, Gabriela D Bertoldi, Federico Ussher, Silvia Christiansen, Carlos Lifschitz, Marina Orsi
OBJECTIVES: The aim of the study was to determine whether esophageal baseline impedance (BI) values in children could be predictive of esophagitis. MATERIALS AND METHODS: Multichannel intraluminal impedance (MII) tracings of children 3 to 17 years of age suspected of having gastroesophageal reflux and esophagitis, who had also undergone upper endoscopy with multiple esophageal biopsies, were reviewed. Patients with eosinophilic esophagitis were excluded. Esophagitis was assessed by macroscopic and microscopic parameters...
September 2017: Journal of Pediatric Gastroenterology and Nutrition
Lukas Goertz, Stefan Werner Schneider, Anna Desch, Frank Thomas Mayer, Julian Koett, Kai Nowak, Ioannis Karampinis, Michael K Bohlmann, Viktor Umansky, Alexander Thomas Bauer
Von Willebrand factor (VWF) serves as a nidus for platelet aggregation and thrombosis. We hypothesize that VWF fibers contribute to the development of venous thromboembolism (VTE) and to metastasis formation. Here, we show that vascular and lymphatic endothelial cells (ECs) express VWF in vitro and release VWF fibers after activation by tumor cell supernatants. In contrast, an ex vivo analysis of primary mouse tumors revealed the presence of VWF fibers in the blood microvasculature but not in lymphatic vessels...
October 18, 2016: Oncotarget
Karen Buch, Raymond Groller, Rohini N Nadgir, Akifumi Fujita, Muhammad M Qureshi, Osamu Sakai
OBJECTIVE: Chronic cerebrospinal vascular insufficiency is a proposed condition of intraluminal stenosis of the internal jugular vein (IJV) that impedes venous flow from the brain. Calculations of IJV stenosis are vague and described in veins with at least a 50% reduction in IJV caliber at a specific level. The purpose of this study was to assess normal changes in anatomic caliber of the course of the IJV in a generalized population. MATERIALS AND METHODS: Images from 500 consecutive contrast-enhanced neck CT studies performed in January-July 2011 were reviewed...
May 2016: AJR. American Journal of Roentgenology
Drew C Baird, Dausen J Harker, Aaron S Karmes
Gastroesophageal reflux is defined as the passage of stomach contents into the esophagus with or without accompanied regurgitation (spitting up) and vomiting. It is a normal physiologic process that occurs throughout the day in infants and less often in children and adolescents. Gastroesophageal reflux disease (GERD) is reflux that causes troublesome symptoms or leads to medical complications. The diagnoses of gastroesophageal reflux and GERD are based on the history and physical examination. Diagnostic tests, such as endoscopy, barium study, multiple intraluminal impedance, and pH monitoring, are reserved for when there are atypical symptoms, warning signs, doubts about the diagnosis, or suspected complications or treatment failure...
October 15, 2015: American Family Physician
S Salvatore, A Salvatoni, D Ummarino, A Ghanma, R Van der Pol, A Rongen, M Fuoti, F Meneghin, M Alexander Benninga, Y Vandenplas
Esophageal multiple intraluminal impedance baseline is an additional impedance parameter that was recently related to esophageal integrity. The aim of this study was to assess the relationship between mean esophageal impedance value and endoscopic findings in a large group of children. Children with symptoms of gastroesophageal reflux submitted to both endoscopy and impedance were included. Esophagitis was graded according to the Los Angeles classification. Mean impedance value was automatically calculated over 24-hour tracings...
January 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
R Katra, Z Kabelka, M Jurovcik, O Hradsky, J Kraus, E Pavlik, E Nartova, P Lukes, J Astl
OBJECTIVES: The aim of this pilot study was to investigate an association between laryngopharyngeal reflux detected by combined multiple intraluminal impedance and pH monitoring and Helicobacter pylori in adenoid hyperplasia detected with real time polymerase chain reaction (PCR). METHODS: The study group consisted of 30 children (median age 5.34 years) with extraesophageal symptoms of gastroesophageal reflux disease with adenoid hyperplasia. All children underwent adenoidectomy with subsequent PCR detection of H...
August 2014: International Journal of Pediatric Otorhinolaryngology
J H Kim, R K Mittal, N Patel, M Ledgerwood, V Bhargava
BACKGROUND: Esophageal multiple intraluminal impedance (MII) measurement has been used to detect gastro-esophageal reflux and bolus transport. It is not clear if MII can detect changes in luminal cross sectional area (CSA) during bolus transport. Intraluminal ultrasound (US) images, MII, and high resolution manometry (HRM) were recorded simultaneously to determine temporal relationship between CSA and impedance during esophageal bolus transport and to define the relationship between peak distension and nadir impedance...
August 2014: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Yichen Wan, Yan Yan, Furong Ma, Li Wang, Peiquan Lu, Allison Maytag, Jack J Jiang
OBJECTIVE: To seek a deeper and more comprehensive understanding of two major diagnostic methods for laryngopharyngeal reflux by exploring whether and how differences exist before and after treatment between patients diagnosed by either Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) or 24-hour pH monitoring. MATERIALS AND METHODS: Two groups of patients who confirmed laryngopharyngeal reflux disease (LPRD) by either a combination of RSI and RFS (Questionnaire group, 35 patients) or 24-hour multichannel intraluminal impedance (MII) pH monitoring (pH Group, 23 patients) were recruited...
May 2014: Journal of Voice: Official Journal of the Voice Foundation
Elie G Abu Jawdeh, Richard J Martin
Apnea of prematurity and gastroesophageal reflux (GER) are both common occurrences in preterm infants and widely perceived to be causally related. We seek in this review to provide a potential guideline for neonatal GER non-pharmacologic and pharmacologic therapy. Available physiologic data suggest that when there is a temporal relationship apnea may be more likely to predispose to GER via esophageal sphincter relaxation than vice versa. Measurement of multiple intraluminal impedance via esophageal catheter in addition to esophageal pH has enhanced our understanding of GER, although it also did not demonstrate a causal relationship between apnea and GER...
June 2013: Early Human Development
Silvia Salvatore, Alessandro Salvatoni, Marieke Van Berkel, Kristel Van Steen, Dario Unmarino, Abdallah Ghanma, Bruno Hauser, Yvan Vandenplas
OBJECTIVE: Esophageal impedance (multichannel intraluminal impedance [MII]) baseline (impedance baseline [IB]) has been recently considered to be related to esophageal integrity. The aim of this study was to analyze the age effect on IB in a large population of pediatric patients. DESIGN: A total of 816 children with symptoms of gastroesophageal reflux and submitted to MII were included. Mean IB was automatically calculated in the different MII channels (Chs) throughout 24-hour tracings by the specific software without removing any episode of increased/decreased IB...
October 2013: Journal of Pediatric Gastroenterology and Nutrition
Yvan Vandenplas
INTRODUCTION: The diagnosis of gastroesophageal reflux disease (GERD) is challenging. The wide variation in symptoms is a major reason for the controversies. Since the expression of GERD varies from nonerosive reflux disease over Barrett's esophagus to chronic respiratory disease, it is clear that not one investigation technique will provide an answer in all situations. AREAS COVERED: Relevant literature published in PubMed and CINAHL and recent guidelines were collected and reviewed...
May 2013: Expert Opinion on Medical Diagnostics
Hong Zhu, Sara Guariglia, Raymond Y L Yu, Wenjing Li, Deborah Brancho, Hector Peinado, David Lyden, James Salzer, Craig Bennett, Chi-Wing Chow
Charcot-Marie-Tooth (CMT) disease is an inherited neurological disorder. Mutations in the small integral membrane protein of the lysosome/late endosome (SIMPLE) account for the rare autosomal-dominant demyelination in CMT1C patients. Understanding the molecular basis of CMT1C pathogenesis is impeded, in part, by perplexity about the role of SIMPLE, which is expressed in multiple cell types. Here we show that SIMPLE resides within the intraluminal vesicles of multivesicular bodies (MVBs) and inside exosomes, which are nanovesicles secreted extracellularly...
June 2013: Molecular Biology of the Cell
Djamal Djeddi, Danny Cantin, Nathalie Samson, Hao Tian, Jean-Paul Praud
OBJECTIVES: It is presently recommended that oral feeding be started in premature infants as soon as possible, often at an age at which nasal continuous positive airway pressure (nCPAP) is still required for ventilatory support. Our previous data showed that application of nCPAP up to 10 cmH2O in full-term lambs had no deleterious effect on cardiorespiratory safety, feeding efficiency, or on nutritive swallowing-breathing coordination. Besides fear of swallowing-breathing coordination disturbances, esophageal motility disruption by nCPAP could be a reason to delay oral feeding...
August 2013: Journal of Pediatric Gastroenterology and Nutrition
Oliver O Koch, Adolf Kaindlstorfer, Stavros A Antoniou, Georg Spaun, Rudolph Pointner, Lee L Swanstrom
BACKGROUND: Subjective and especially objective data after endoluminal full-thickness gastroplication are scarce. OBJECTIVE: To evaluate symptoms and reflux activity 12 months after gastroplication by using multichannel intraluminal impedance monitoring. DESIGN: Open-label, prospective, single-center study. SETTING: Tertiary referral hospital in Zell am See, Austria. PATIENTS: Subjects without hiatal hernias with documented GERD and persistent or recurrent symptoms despite treatment with a proton pump inhibitor...
January 2013: Gastrointestinal Endoscopy
Y-L Xiao, F-Q Liu, J Li, J-T Lv, J-K Lin, W-P Wen, M-H Chen
BACKGROUND: The profiles of gastroesophageal reflux (GER) and laryngopharyngeal reflux (LPR) in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS) have never been explored. The aim of the study was to investigate the reflux profile in OSAHS patients. METHODS: Consecutive snoring out-patients suspected with having OSAHS and 20 healthy volunteers were included. All subjects underwent simultaneous 24-h combined multichannel intraluminal impedance-pH (MII-pH) monitoring and polysomnography...
June 2012: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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